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Conserved domains on  [gi|503486572|ref|WP_013721233|]
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GntR family transcriptional regulator [Alicycliphilus denitrificans]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
21-237 6.42e-32

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 116.18  E-value: 6.42e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572  21 PEPAADVPESAADTVFHGIVQGLAQQRFVPGQRLVEVDLAAQFGVSRASVREALQRLAAEGLVDLFRNKGAAIRTLSARE 100
Cdd:COG1802    2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572 101 TLEVLDVAERMTGLLARSAARAVAAGAPRApIEDALARLHEADRGQGQDAFASARRALYRALLSTSGSRELRRLLPTIHM 180
Cdd:COG1802   82 IRELYEVRAALEGLAARLAAERATPADLAR-LRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRA 160
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572 181 ---PIVYAQHRPAALQRIRMRDYRAMCEAVLQGDEDAADAAGMQHVRNVREAIEAAIASD 237
Cdd:COG1802  161 rlrRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAA 220
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
21-237 6.42e-32

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 116.18  E-value: 6.42e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572  21 PEPAADVPESAADTVFHGIVQGLAQQRFVPGQRLVEVDLAAQFGVSRASVREALQRLAAEGLVDLFRNKGAAIRTLSARE 100
Cdd:COG1802    2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572 101 TLEVLDVAERMTGLLARSAARAVAAGAPRApIEDALARLHEADRGQGQDAFASARRALYRALLSTSGSRELRRLLPTIHM 180
Cdd:COG1802   82 IRELYEVRAALEGLAARLAAERATPADLAR-LRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRA 160
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572 181 ---PIVYAQHRPAALQRIRMRDYRAMCEAVLQGDEDAADAAGMQHVRNVREAIEAAIASD 237
Cdd:COG1802  161 rlrRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAA 220
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
39-91 3.44e-12

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 59.77  E-value: 3.44e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 503486572  39 IVQGLAQQRFVPGQRLV-EVDLAAQFGVSRASVREALQRLAAEGLVDLFRNKGA 91
Cdd:cd07377   10 LREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGT 63
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
32-93 7.11e-11

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 56.47  E-value: 7.11e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503486572   32 ADTVFHGIVQGLAQQRFVPGQRLVEV-DLAAQFGVSRASVREALQRLAAEGLVDLFRNKGAAI 93
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDKLPSErELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
35-93 4.68e-09

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 51.42  E-value: 4.68e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572    35 VFHGIVQGLAQQRFVPGQRL-VEVDLAAQFGVSRASVREALQRLAAEGLVDLFRNKGAAI 93
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
39-90 6.89e-07

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 48.86  E-value: 6.89e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503486572  39 IVQGLAQqrfvPGQRLV-EVDLAAQFGVSRASVREALQRLAAEGLvdLFRNKG 90
Cdd:PRK09464  23 ILEGTLR----PGEKLPpERELAKQFDVSRPSLREAIQRLEAKGL--LLRRQG 69
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
21-237 6.42e-32

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 116.18  E-value: 6.42e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572  21 PEPAADVPESAADTVFHGIVQGLAQQRFVPGQRLVEVDLAAQFGVSRASVREALQRLAAEGLVDLFRNKGAAIRTLSARE 100
Cdd:COG1802    2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572 101 TLEVLDVAERMTGLLARSAARAVAAGAPRApIEDALARLHEADRGQGQDAFASARRALYRALLSTSGSRELRRLLPTIHM 180
Cdd:COG1802   82 IRELYEVRAALEGLAARLAAERATPADLAR-LRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRA 160
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572 181 ---PIVYAQHRPAALQRIRMRDYRAMCEAVLQGDEDAADAAGMQHVRNVREAIEAAIASD 237
Cdd:COG1802  161 rlrRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAA 220
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
28-237 5.36e-17

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 77.28  E-value: 5.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572  28 PESAADTVFHGIVQGLAQQRFVPGQRL-VEVDLAAQFGVSRASVREALQRLAAEGLVDLFRNKGAAIRTLSARETLEVLD 106
Cdd:COG2186    5 RRSLAEQVAEQLRELILSGELKPGDRLpSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDPLA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572 107 VAERMTGLLAR--------------SAARAVAAGAPRAPIEDALARLHEADRgqGQDAFASARRALYRALLSTSGSRELR 172
Cdd:COG2186   85 LLLALDDASLRdllearlalepeaaRLAAERATDEDLARLEAALAEMEAAAD--DGEAFAEADLAFHRAIAEASGNPLLA 162
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503486572 173 RLLPTIH---MPIVYAQHRPAALQRIRMRDYRAMCEAVLQGDEDAADAAGMQHVRNVREAIEAAIASD 237
Cdd:COG2186  163 LLLESLRellRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAER 230
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
39-91 3.44e-12

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 59.77  E-value: 3.44e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 503486572  39 IVQGLAQQRFVPGQRLV-EVDLAAQFGVSRASVREALQRLAAEGLVDLFRNKGA 91
Cdd:cd07377   10 LREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGT 63
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
32-93 7.11e-11

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 56.47  E-value: 7.11e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503486572   32 ADTVFHGIVQGLAQQRFVPGQRLVEV-DLAAQFGVSRASVREALQRLAAEGLVDLFRNKGAAI 93
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDKLPSErELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
35-93 4.68e-09

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 51.42  E-value: 4.68e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572    35 VFHGIVQGLAQQRFVPGQRL-VEVDLAAQFGVSRASVREALQRLAAEGLVDLFRNKGAAI 93
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
39-90 1.09e-07

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 51.02  E-value: 1.09e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503486572  39 IVQGLAQQRFVPGQRL-VEVDLAAQFGVSRASVREALQRLAAEGLVDLFRNKG 90
Cdd:COG2188   14 LRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRG 66
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
39-90 6.89e-07

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 48.86  E-value: 6.89e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503486572  39 IVQGLAQqrfvPGQRLV-EVDLAAQFGVSRASVREALQRLAAEGLvdLFRNKG 90
Cdd:PRK09464  23 ILEGTLR----PGEKLPpERELAKQFDVSRPSLREAIQRLEAKGL--LLRRQG 69
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
40-243 9.45e-07

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 48.61  E-value: 9.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572  40 VQGLAQQRFV-PGQRL-VEVDLAAQFGVSRASVREALQRLAAEGLVDLFRNKGAAIRTLSarETLEVLDVAERMTGLLAR 117
Cdd:PRK10421  11 VRALIEEKNLeAGMKLpAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRH--ETWSEQNIVQPLKTLMAD 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572 118 SAARAVAAGAPRAPIEDALA-----RLHEADRGQGQDAF--------ASARRALYRALLSTSGS-------RELRRLLPT 177
Cdd:PRK10421  89 DPDYSFDILEARHAIEASTAwhaamRATPGDKEKIQLCFeatlsedpDLASQADVRFHLAIAEAshnvvllQTMRGFFDV 168
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572 178 IHMPIVYAQHR----PAALQRIRMRdYRAMCEAVLQGDEDAADAAGMQHVRNVREAIEaaiASDLGQARR 243
Cdd:PRK10421 169 LQSSVKQSRQRmylvPPVFSQLTEQ-HQAVMDAILAGDAEGARKAMMAHLSFVHTTIK---RFDEDQARQ 234
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
57-111 7.95e-06

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 44.04  E-value: 7.95e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503486572  57 VDLAAQFGVSRASVREALQRLAAEGLVDLFRNKG---------AAIRTLSARETLEVL-------------DVAERM 111
Cdd:COG1321   28 SDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGitlteegreLALRIVRRHRLLERFlvevlgvdwdeahEEAERL 104
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
33-111 9.13e-06

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 45.40  E-value: 9.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572  33 DTVFHGIVQGLAQQRFVPGQRL-VEVDLAAQFGVSRASVREALQRLAAEGLVDLFRNKGAAIRTLSARETLEVLDVAERM 111
Cdd:PRK03837  16 EEVEERLEQMIRSGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSADTIIGQLSGMAKD 95
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
132-225 9.51e-06

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 43.89  E-value: 9.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572   132 IEDALARLHEA-DRGQGQDAFASARRALYRALLSTSGSRELRRLLPTIHMPIVYAQHRPAALQRIRMRDYRAMCEAVLQG 210
Cdd:smart00895  29 LEALLDAMEAAaAAGDDLEEFAELDREFHRALAEAAGNPVLLELLESLRARLRRLRRLSLEAARRALDEHRAILDAIRAR 108
                           90
                   ....*....|....*
gi 503486572   211 DEDAADAAGMQHVRN 225
Cdd:smart00895 109 DAEAARAAMREHLEA 123
PRK10225 PRK10225
Uxu operon transcriptional regulator;
39-104 1.18e-04

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 42.31  E-value: 1.18e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503486572  39 IVQGLAQQRFVPGQRLV-EVDLAAQFGVSRASVREALQRLAAEGLVDLFRnkGAAIRTLSARETLEV 104
Cdd:PRK10225  18 IRDLIIKTPYNPGERLPpEREIAEMLDVTRTVVREALIMLEIKGLVEVRR--GAGIYVLDSSGSHNT 82
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
32-103 1.13e-03

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 39.64  E-value: 1.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503486572  32 ADTVFHGIVQGLAQQRFVPGQRLVEV-DLAAQFGVSRASVREALQRLAAEGLVDLFRNKGAAIRTLSARETLE 103
Cdd:PRK15481   7 ANEIFDSIRQLIQAGRLRPGDSLPPVrELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGSPSPVALE 79
PRK11402 PRK11402
transcriptional regulator PhoB;
34-102 1.69e-03

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 38.66  E-value: 1.69e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572  34 TVFHGIVQGLAQQRFVPGQRL-VEVDLAAQFGVSRASVREALQRLAAEGLVDLFRNKGAAIRTLSARETL 102
Cdd:PRK11402  13 TVRQRLLDDIAQGVYQAGQQIpTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENAL 82
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
30-84 2.39e-03

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 38.66  E-value: 2.39e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572  30 SAADTVFHGIVQGLAQQ----RFVPGQRLVEV-DLAAQFGVSRASVREALQRLAAEGLVD 84
Cdd:COG1167    8 DSSGPLYLQLADALREAilsgRLPPGDRLPSSrELAAQLGVSRSTVVRAYEELEAEGLIE 67
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
48-115 2.55e-03

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 37.95  E-value: 2.55e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503486572  48 FVPGQRLVEVDLAAQFGVSRASVREALQRLAAEGLVDLFRNKGAAIRTLSARETLEVLDVAERMTGLL 115
Cdd:PRK11534  25 FQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAML 92
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
39-81 6.92e-03

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 36.77  E-value: 6.92e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 503486572  39 IVQGLAQQRFVPGQRL-VEVDLAAQFGVSRASVREALQRLAAEG 81
Cdd:PRK04984  16 IIESIWNNRFPPGSILpAERELSELIGVTRTTLREVLQRLARDG 59
PRK11886 PRK11886
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA;
43-90 7.06e-03

bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA;


Pssm-ID: 237010 [Multi-domain]  Cd Length: 319  Bit Score: 37.07  E-value: 7.06e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 503486572  43 LAQQRFVPGQrlvevDLAAQFGVSRASVREALQRLAAEGlVDLFRNKG 90
Cdd:PRK11886  13 LADGDFHSGE-----QLGEELGISRAAIWKHIQTLEEWG-LDIFSVKG 54
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
132-218 8.41e-03

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 35.42  E-value: 8.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503486572  132 IEDALARLHEADRGQGQDAFASARRALYRALLSTSGSRELRRLLPTIH---MPIVYAQHRPAALQRIRMRDYRAMCEAVL 208
Cdd:pfam07729  29 LEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWdrlRRLRRLLLSSPGRLRASLEEHRAILDAIR 108
                          90
                  ....*....|
gi 503486572  209 QGDEDAADAA 218
Cdd:pfam07729 109 ARDPEAARAA 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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