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Conserved domains on  [gi|503251087|ref|WP_013485748|]
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GntR family transcriptional regulator [Ethanoligenens harbinense]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448193)

GntR family transcriptional regulator simlar to MngR, which is involved in the regulation of mannosyl-glycerate transport and metabolism

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0003700
PubMed:  33509775|26172911|2060763

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
8-118 1.06e-24

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


:

Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 91.39  E-value: 1.06e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503251087   8 FHIDKKLSVPLFKQIIVQIEHFILLDIWKTDTVLPSLRTLASHLNINVNTVQKSYTILKDQNIIYVYHSEKWLISENAKH 87
Cdd:COG1725    1 IRIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARE 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 503251087  88 ILQLEYEKRLDE-LYEIAFELYLMHVDQAEVI 118
Cdd:COG1725   81 LLEERREEFLEEaLRELVAEARRLGLSLEELL 112
 
Name Accession Description Interval E-value
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
8-118 1.06e-24

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 91.39  E-value: 1.06e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503251087   8 FHIDKKLSVPLFKQIIVQIEHFILLDIWKTDTVLPSLRTLASHLNINVNTVQKSYTILKDQNIIYVYHSEKWLISENAKH 87
Cdd:COG1725    1 IRIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARE 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 503251087  88 ILQLEYEKRLDE-LYEIAFELYLMHVDQAEVI 118
Cdd:COG1725   81 LLEERREEFLEEaLRELVAEARRLGLSLEELL 112
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 17-75 2.40e-10

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 53.22  E-value: 2.40e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 503251087  17 PLFKQIIVQIEHFILLDIWKTDTVLPSLRTLASHLNINVNTVQKSYTILKDQNIIYVYH 75
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRP 59
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
25-73 2.49e-03

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 34.47  E-value: 2.49e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 503251087    25 QIEHFILLDIWKTDTVLPSLRTLASHLNINVNTVQKSYTILKDQNIIYV 73
Cdd:smart00345   4 RLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQR 52
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 18-71 6.57e-03

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 33.36  E-value: 6.57e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 503251087   18 LFKQIIVQIEHFILLDIWKTDTVLPSLRTLASHLNINVNTVQKSYTILKDQNII 71
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLV 54
 
Name Accession Description Interval E-value
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
8-118 1.06e-24

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 91.39  E-value: 1.06e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503251087   8 FHIDKKLSVPLFKQIIVQIEHFILLDIWKTDTVLPSLRTLASHLNINVNTVQKSYTILKDQNIIYVYHSEKWLISENAKH 87
Cdd:COG1725    1 IRIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARE 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 503251087  88 ILQLEYEKRLDE-LYEIAFELYLMHVDQAEVI 118
Cdd:COG1725   81 LLEERREEFLEEaLRELVAEARRLGLSLEELL 112
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 8-72 1.16e-12

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 63.69  E-value: 1.16e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503251087   8 FHIDKKLSVPLFKQIIVQIEHFILLDIWKTDTVLPSLRTLASHLNINVNTVQKSYTILKDQNIIY 72
Cdd:COG1167    3 IRLDRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIE 67
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 17-75 2.40e-10

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 53.22  E-value: 2.40e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 503251087  17 PLFKQIIVQIEHFILLDIWKTDTVLPSLRTLASHLNINVNTVQKSYTILKDQNIIYVYH 75
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRP 59
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
15-72 4.02e-06

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 44.47  E-value: 4.02e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 503251087  15 SVPLFKQIIVQIEHFILLDIWKTDTVLPSLRTLASHLNINVNTVQKSYTILKDQNIIY 72
Cdd:COG2188    3 PVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLE 60
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
25-73 2.49e-03

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 34.47  E-value: 2.49e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 503251087    25 QIEHFILLDIWKTDTVLPSLRTLASHLNINVNTVQKSYTILKDQNIIYV 73
Cdd:smart00345   4 RLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQR 52
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 18-71 6.57e-03

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 33.36  E-value: 6.57e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 503251087   18 LFKQIIVQIEHFILLDIWKTDTVLPSLRTLASHLNINVNTVQKSYTILKDQNII 71
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLV 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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