NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|502864341|ref|WP_013099317|]
View 

MULTISPECIES: MIP/aquaporin family protein [Enterobacter]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 10001739)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11964478|8849412|11473620
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 6-256 1.58e-89

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


:

Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 265.45  E-value: 1.58e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341   6 TLKGQCIAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDGRK 85
Cdd:COG0580    1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  86 VVPFIISQFAGAFCAAALVYGLYYNLFIDFEqthhmvrgsvESLDLAGIFSTYPNPHINFVQAFAVEMVITAILMGVILA 165
Cdd:COG0580   81 VLPYIIAQLLGAFLGAALVYLIYGGHFDATE----------DGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341 166 LTDDGNgiPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDIGPKAFAFIagwgdvaFTGGKDIPYFLVPLFAPVVGAA 245
Cdd:COG0580  151 ITDKRA--APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL-------GKGGSDWGYLWVPIVAPILGAA 221

                        250
                 ....*....|.
gi 502864341 246 LGAFSYRKLIG 256
Cdd:COG0580  222 LAALLYRALFG 232
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 6-256 1.58e-89

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 265.45  E-value: 1.58e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341   6 TLKGQCIAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDGRK 85
Cdd:COG0580    1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  86 VVPFIISQFAGAFCAAALVYGLYYNLFIDFEqthhmvrgsvESLDLAGIFSTYPNPHINFVQAFAVEMVITAILMGVILA 165
Cdd:COG0580   81 VLPYIIAQLLGAFLGAALVYLIYGGHFDATE----------DGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341 166 LTDDGNgiPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDIGPKAFAFIagwgdvaFTGGKDIPYFLVPLFAPVVGAA 245
Cdd:COG0580  151 ITDKRA--APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL-------GKGGSDWGYLWVPIVAPILGAA 221

                        250
                 ....*....|.
gi 502864341 246 LGAFSYRKLIG 256
Cdd:COG0580  222 LAALLYRALFG 232
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 10-254 2.61e-81

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 244.47  E-value: 2.61e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  10 QCIAEFLGTGLLIFFGVGCVAALKVAG-ASFGQWEISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDGRKVVP 88
Cdd:cd00333    2 KYLAEFLGTFLLVFFGCGSVLAVKLAGgASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  89 FIISQFAGAFCAAALVYGLYYNLFIDFEQTHHMVrgsvesldlAGIFSTYPNPHINFVQAFAVEMVITAILMGVILALTD 168
Cdd:cd00333   82 YIIAQLLGAILGAALLYGLYYGLYLEFLGANNIV---------AGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTD 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341 169 DGNGIPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDIGPKAFAFIAgwgdvaftggKDIPYFLVPLFAPVVGAALGA 248
Cdd:cd00333  153 DPNGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA----------RHWHYFWVYWVGPLIGAIAGA 222


                 ....*.
gi 502864341 249 FSYRKL 254
Cdd:cd00333  223 LVYDYV 228
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 1-251 6.11e-71

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 217.96  E-value: 6.11e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341    1 MSQTSTLKGQCIAEFLGTGLLIFFGVGCVAALKVAGASFG--QWE-ISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALWL 77
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAvsGLLaVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341   78 FACFDGRKVVPFIISQFAGAFCAAALVYGLYYNLfidfeqthhmvrgsveslDLAGIFSTYPNPHINFVQAFAVEMVITA 157
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGL------------------QRAGLFANTLAPGVNAGQAFVVEIILTF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  158 ILMGVILALTDDGNGIPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDIGPkafAFIAGwgdvaftggkDIPYFLVPL 237
Cdd:pfam00230 143 QLVYCVFATTDDRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGP---AVVLW----------KWDDHWVYW 209

                         250
                  ....*....|....
gi 502864341  238 FAPVVGAALGAFSY 251
Cdd:pfam00230 210 VGPFIGAALGALVY 223
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 10-256 2.04e-64

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 203.82  E-value: 2.04e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  10 QCIAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDGRKVVPF 89
Cdd:PTZ00016  52 EYVAEFLGTFVLLFFGEGVVATTHTVGNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLPGY 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  90 IISQFAGAFCAAALVYGLYYNLFIDFEQTHHMVRGSveSLDLAGIFSTYPNphINFVQAFAVEMVITAILMGVILALTDD 169
Cdd:PTZ00016 132 FVAQLLGAFVGAACVYGLYYGFFKDHGIPELPWETM--ANGFAGVFATYPR--EGNFYAIFSELILTAILLLVILAITDP 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341 170 GNGIPRGPLaPLLIGLLIAVIGASMGPLTGFAMNPARDIGPKAFAFIAgWGDVAFTggKDIPYFLVPLFAPVVGAALGAF 249
Cdd:PTZ00016 208 NNCPAFNYL-PVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAIL-WGSEVFT--KDNYYFWVPLVAPFVGAVLGMF 283


                 ....*..
gi 502864341 250 SYRKLIG 256
Cdd:PTZ00016 284 LYDKFIP 290
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 13-251 7.72e-64

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 199.45  E-value: 7.72e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341   13 AEFLGTGLLIFFGVGCVAALKVAG-----ASFGQWEISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDGRKVV 87
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGaygavGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341   88 PFIISQFAGAFCAAALVYGLYYNLfidFEQTHHMVRGsvesldlagifstyPNPHINFVQAFAVEMVITAILMGVILALT 167
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGL---FPGNLAVNGS--------------ASAGVSSGQAFFVEFIGTAILVLVIFATT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  168 DDGNGIPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDIGPKAFAFIAGWGDvaftggkdipyFLVPLFAPVVGAALG 247
Cdd:TIGR00861 144 DDRNRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGWGN-----------HWVYWVGPIIGAILG 212


                  ....
gi 502864341  248 AFSY 251
Cdd:TIGR00861 213 ALVY 216
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 6-256 1.58e-89

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 265.45  E-value: 1.58e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341   6 TLKGQCIAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDGRK 85
Cdd:COG0580    1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  86 VVPFIISQFAGAFCAAALVYGLYYNLFIDFEqthhmvrgsvESLDLAGIFSTYPNPHINFVQAFAVEMVITAILMGVILA 165
Cdd:COG0580   81 VLPYIIAQLLGAFLGAALVYLIYGGHFDATE----------DGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341 166 LTDDGNgiPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDIGPKAFAFIagwgdvaFTGGKDIPYFLVPLFAPVVGAA 245
Cdd:COG0580  151 ITDKRA--APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL-------GKGGSDWGYLWVPIVAPILGAA 221

                        250
                 ....*....|.
gi 502864341 246 LGAFSYRKLIG 256
Cdd:COG0580  222 LAALLYRALFG 232
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 10-254 2.61e-81

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 244.47  E-value: 2.61e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  10 QCIAEFLGTGLLIFFGVGCVAALKVAG-ASFGQWEISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDGRKVVP 88
Cdd:cd00333    2 KYLAEFLGTFLLVFFGCGSVLAVKLAGgASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  89 FIISQFAGAFCAAALVYGLYYNLFIDFEQTHHMVrgsvesldlAGIFSTYPNPHINFVQAFAVEMVITAILMGVILALTD 168
Cdd:cd00333   82 YIIAQLLGAILGAALLYGLYYGLYLEFLGANNIV---------AGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTD 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341 169 DGNGIPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDIGPKAFAFIAgwgdvaftggKDIPYFLVPLFAPVVGAALGA 248
Cdd:cd00333  153 DPNGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA----------RHWHYFWVYWVGPLIGAIAGA 222


                 ....*.
gi 502864341 249 FSYRKL 254
Cdd:cd00333  223 LVYDYV 228
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 1-251 6.11e-71

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 217.96  E-value: 6.11e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341    1 MSQTSTLKGQCIAEFLGTGLLIFFGVGCVAALKVAGASFG--QWE-ISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALWL 77
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAvsGLLaVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341   78 FACFDGRKVVPFIISQFAGAFCAAALVYGLYYNLfidfeqthhmvrgsveslDLAGIFSTYPNPHINFVQAFAVEMVITA 157
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGL------------------QRAGLFANTLAPGVNAGQAFVVEIILTF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  158 ILMGVILALTDDGNGIPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDIGPkafAFIAGwgdvaftggkDIPYFLVPL 237
Cdd:pfam00230 143 QLVYCVFATTDDRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGP---AVVLW----------KWDDHWVYW 209

                         250
                  ....*....|....
gi 502864341  238 FAPVVGAALGAFSY 251
Cdd:pfam00230 210 VGPFIGAALGALVY 223
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 10-256 2.04e-64

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 203.82  E-value: 2.04e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  10 QCIAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDGRKVVPF 89
Cdd:PTZ00016  52 EYVAEFLGTFVLLFFGEGVVATTHTVGNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLPGY 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  90 IISQFAGAFCAAALVYGLYYNLFIDFEQTHHMVRGSveSLDLAGIFSTYPNphINFVQAFAVEMVITAILMGVILALTDD 169
Cdd:PTZ00016 132 FVAQLLGAFVGAACVYGLYYGFFKDHGIPELPWETM--ANGFAGVFATYPR--EGNFYAIFSELILTAILLLVILAITDP 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341 170 GNGIPRGPLaPLLIGLLIAVIGASMGPLTGFAMNPARDIGPKAFAFIAgWGDVAFTggKDIPYFLVPLFAPVVGAALGAF 249
Cdd:PTZ00016 208 NNCPAFNYL-PVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAIL-WGSEVFT--KDNYYFWVPLVAPFVGAVLGMF 283


                 ....*..
gi 502864341 250 SYRKLIG 256
Cdd:PTZ00016 284 LYDKFIP 290
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 13-251 7.72e-64

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 199.45  E-value: 7.72e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341   13 AEFLGTGLLIFFGVGCVAALKVAG-----ASFGQWEISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDGRKVV 87
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGaygavGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341   88 PFIISQFAGAFCAAALVYGLYYNLfidFEQTHHMVRGsvesldlagifstyPNPHINFVQAFAVEMVITAILMGVILALT 167
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGL---FPGNLAVNGS--------------ASAGVSSGQAFFVEFIGTAILVLVIFATT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  168 DDGNGIPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDIGPKAFAFIAGWGDvaftggkdipyFLVPLFAPVVGAALG 247
Cdd:TIGR00861 144 DDRNRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGWGN-----------HWVYWVGPIIGAILG 212


                  ....
gi 502864341  248 AFSY 251
Cdd:TIGR00861 213 ALVY 216
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 12-261 7.14e-25

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 100.32  E-value: 7.14e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  12 IAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDGRKVVPFII 91
Cdd:PLN00183  49 LAEMVGTFILMFCVCGIIASTQLSGGEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPLYIT 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  92 SQFAGAfCAAALVYGLYYNLFIDFEQThhmvrgsvesldlagifstypNPHINFVQAFAVEMVITAILMGVILALTDDGN 171
Cdd:PLN00183 129 AQTVGS-VLATYVGVSVYGVKADLMTT---------------------KPAQGCSSAFWVEFIATFIVMFLAASLTSQPQ 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341 172 GIprGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDIGPKafafIAGWgdvaftggkDIPYFLVPLFAPVVGAALGAFSY 251
Cdd:PLN00183 187 SL--GHLSGFVIGIAIGLAVLITGPVSGGSMNPARSLGPA----IVSW---------DFKDIWIYITAPTIGAVAGALMF 251

                        250
                 ....*....|
gi 502864341 252 RKLIGRHLPC 261
Cdd:PLN00183 252 HLLRLRTQPC 261
PLN00184 PLN00184
aquaporin NIP1; Provisional
 12-251 2.65e-23

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 96.63  E-value: 2.65e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  12 IAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDGRKVVPFII 91
Cdd:PLN00184  58 IAEVLGTYFLVFTGCASVVVNMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLKQVPAYVI 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  92 SQFAGAFCAAA---LVYGLYYNLfidFEQTHHMVRGSVesldlagifstypnPHINFVQAFAVEMVITAILMGVILALTD 168
Cdd:PLN00184 138 SQVIGSTLAAAtlrLLFGLDHDV---CSGKHDVFIGSS--------------PVGSDLQAFVMEFIVTFYLMFIISGVAT 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341 169 DGNGIprGPLAPLLIG--LLIAVIGAsmGPLTGFAMNPARDIGPKafafiagwgdVAFTGGKDIPYFLVplfAPVVGAAL 246
Cdd:PLN00184 201 DNRAI--GELAGLAIGstVLLNVLIA--APVSSASMNPGRSLGPA----------MVYGCYKGIWIYIV---APTLGAIA 263


                 ....*
gi 502864341 247 GAFSY 251
Cdd:PLN00184 264 GAWVY 268
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 6-251 1.59e-22

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 94.21  E-value: 1.59e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341   6 TLKGQCIAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDGRK 85
Cdd:PLN00182  40 CLTQKLIAEMIGTYFIIFSGCGVVVVNVLYGGTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQ 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  86 VVPFIISQFAGAFCAAAlvyglyyNLFIDFEQTHHMVRGSVesldlagifstypnPHINFVQAFAVEMVITAILMGVILA 165
Cdd:PLN00182 120 VPLYIGAQLTGSLLASL-------TLRLMFNVTPEAFFGTT--------------PTDSSGQALVAEIIISFLLMFVISG 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341 166 LTDDGNGIprGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDIGPkafAFIAGwgdvAFTGgkdipyFLVPLFAPVVGAA 245
Cdd:PLN00182 179 VATDSRAV--GELAGIAVGMTIILNVFVAGPISGASMNPARSLGP---AIVMG----RYKG------IWVYIVGPFVGII 243


                 ....*.
gi 502864341 246 LGAFSY 251
Cdd:PLN00182 244 AGGFVY 249
PRK05420 PRK05420
aquaporin Z; Provisional
 10-257 1.93e-22

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 92.72  E-value: 1.93e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  10 QCIAEFLGTGLLIFFGVG-CVAALKVAGASFGQWEISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDGRKVVP 88
Cdd:PRK05420   4 KLAAEFFGTFWLVFGGCGsAVLAAAFPELGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKELVP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  89 FIISQFAGAFCAAALVYglyynlfidfeqthhMVRGSVESLDLAGI------FSTYPNPHINFVQAFAVEMVITAILMGV 162
Cdd:PRK05420  84 YIIAQVVGGIAAAAVLY---------------LIASGKAGFDLAGSgfasngYGEHSPGGYSLLAALVCEVVLTAFFLLV 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341 163 ILALTDdgNGIPRGpLAPLLIGLLIAVIGASMGPLTGFAMNPARDIGPKAFAfiagwgdvaftGGKDIPYFLVPLFAPVV 242
Cdd:PRK05420 149 ILGATD--KRAPAG-FAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFV-----------GGWALEQLWLFWVAPIV 214

                        250
                 ....*....|....*
gi 502864341 243 GAALGAFSYRKLIGR 257
Cdd:PRK05420 215 GAIIGGLIYRLLLEK 229
PLN00026 PLN00026
aquaporin NIP; Provisional
 13-251 3.39e-19

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 85.30  E-value: 3.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  13 AEFLGTGLLIFFGV-GCVAALKVAGAS--FGQWEISiiwGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDGRKVVPF 89
Cdd:PLN00026  76 AEFVGTFILIFAATaGPIVNQKYDGAEtlIGNAACA---GLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWKHVPAY 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  90 IISQFAGAFCAAALVYGLYynlfidfeqtHHMVRGSVESldlagifstypnPHINFVQAFAVEMVITAILMGVILALTDD 169
Cdd:PLN00026 153 IAAQVSASICASFALKGVF----------HPFMSGGVTV------------PSVSTGQAFALEFIITFNLLFVVTAVATD 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341 170 GNGIprGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDIGPKafafiagwgdVAFTGGKDIPYFLVplfAPVVGAALGAF 249
Cdd:PLN00026 211 TRAV--GELAGIAVGATVMLNILVAGPSTGGSMNPVRTLGPA----------VAAGNYRAIWIYLV---APTLGALAGAG 275


                 ..
gi 502864341 250 SY 251
Cdd:PLN00026 276 TY 277
PLN00166 PLN00166
aquaporin TIP2; Provisional
 12-251 2.40e-09

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 56.48  E-value: 2.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  12 IAEFLGTGLLIFFGVGCVAAL-----KVAGASFGQWEISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDGRKV 86
Cdd:PLN00166  22 LSEFIATLLFVFAGVGSAIAFakltsDAALDPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITIITG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  87 VPFIISQFAGAFCAAALVyglyynlfidfeqthhMVRGSVESLDLAGIFSTypnphINFVQAFAVEMVITAILMGVILAL 166
Cdd:PLN00166 102 FFYWIAQCLGSIVACLLL----------------VFVTNGESVPTHGVAAG-----LGAIEGVVMEIVVTFALVYTVYAT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341 167 TDDGNGIPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDIGPkafAFIAGwgdvaftggkDIPYFLVPLFAPVVGAAL 246
Cdd:PLN00166 161 AADPKKGSLGTIAPIAIGFIVGANILAAGPFSGGSMNPARSFGP---AVVSG----------DFSQIWIYWVGPLVGGAL 227


                 ....*
gi 502864341 247 GAFSY 251
Cdd:PLN00166 228 AGLIY 232
PLN00167 PLN00167
aquaporin TIP5; Provisional
 12-218 7.41e-06

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 46.05  E-value: 7.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  12 IAEFLGTGLLIFFGVGCVAALK-----VAGASFGQWEISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALwlfaCFDGRKV 86
Cdd:PLN00167  26 LAEFISTFFFVFAAVGSAMSSRklmpdAASDPSSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGM----AVGGHIS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  87 VP----FIISQFAGAFCAAalvyglyynLFIDFEQTHHMVRGSVESLDLAGIfstypnphinfvQAFAVEMVITAILMGV 162
Cdd:PLN00167 102 VPtamfYWISQMLASVMAC---------LFLKVTTVGQHVPTYKIAEEMTGF------------GASVLEGVLTFGLVYT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 502864341 163 ILALTDDGNGIPrGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDIGPkafAFIAG 218
Cdd:PLN00167 161 VYAAGDPRRGLL-GAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGS---AVVAG 212
PLN00027 PLN00027
aquaporin TIP; Provisional
 12-251 4.09e-04

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 40.93  E-value: 4.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  12 IAEFLGTGLLIFFGVGCVAA---LKVAGASF--GQWEISIIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDGRKV 86
Cdd:PLN00027  24 LAEFISTLIFVFAGEGSGMAfnkLTDNGSTTpaGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNITLLRG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341  87 VPFIISQFAGAFCAAalvyglyynLFIDFeQTHHMVRGSvesldlagiFSTypNPHINFVQAFAVEMVITAILMGVILAL 166
Cdd:PLN00027 104 ILYWIAQLLGSVVAC---------LLLKF-STGGLETSA---------FSL--SSGVGVWNAFVFEIVMTFGLVYTVYAT 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502864341 167 TDDGNGIPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDIGPKAfafiagwgdVAFTGGKDIPYFLVPLfapvVGAAL 246
Cdd:PLN00027 163 AVDPKKGDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAV---------VSWTWTNHWVYWAGPL----IGGGI 229


                 ....*
gi 502864341 247 GAFSY 251
Cdd:PLN00027 230 AGLVY 234
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH