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Conserved domains on  [gi|502811800|ref|WP_013046776|]
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cobaltochelatase subunit CobT [Candidatus Puniceispirillum marinum]

Protein Classification

histone deacetylase 2( domain architecture ID 11468260)

histone deacetylase 2 (HD2) is a Zn-dependent class I enzyme that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 6-610 0e+00

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


:

Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 977.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800   6 PKFDKEAQFLKSNAAALRAVAGVKECQVTYAGTDTHVGTDDVRLPALPPTATAAQKASLRGAADGAALWIAHHDPKTHKK 85
Cdd:COG4547    3 PKESPAEPFKRALAATLRAIAGDPELEVSFSADRPGLSGDRARLPEPPRRLTAEEVAIARGAADALALRLRHHDAALHAR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  86 HCPNPDGARAIFESAERARVEAIGANDLAGVGANLTAALNQRYETRQIEAPGSADEAGIAEVVRLLLREELTGAPPPQTL 165
Cdd:COG4547   83 LAPQGPEARAVFDALEQARVEALGARRMAGVAANLDAMLEDRYRRAGYARITDRADAPLADALALLVRERLTGRPPPPSA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 166 SMVMDLWRPWVKSRAGDLLDQLEANIDDQSQFAEISRRLIGALetDLGDASSNPDDDADEGSDEDDSGDSQSDQDGE-QS 244
Cdd:COG4547  163 RKLVDLWRDWIEEKAGADLDRLAELLDDQAAFARAVRDLLRDL--DLAEELGEDEDEEDEDDEDDSGEQEEDEEDGEdED 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 245 AVGEDQSEGDDSQSMDDAGDSGSSQEGEMGEADGAEEGMSDgDSPNSDMTGHNANRGTADD---SYRTFETKFDEIVSAA 321
Cdd:COG4547  241 EESDEGAEAEDAEASGDDAEEGESEAAEAESDEMAEEAEGE-DSEEPGEPWRPNAPPPDDPadpDYKVFTTAFDEVVAAE 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 322 DLCDPEELDRLRTMLDRHMENVTSVVGKLANRLQRKLMAHQNRSWDFDLEEGILDAAKLHRVVTQPLSALSYKQEQDTKF 401
Cdd:COG4547  320 DLCDPEELDRLRAYLDQQLAHLQGVVSRLANRLQRRLMAQQNRSWEFDLEEGILDAARLARVVADPTQPLSFKQEKDTEF 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 402 RDTVVTLLLDNSGSMRGRPITIAAVTADILARTLERCGVKVEILGFTTRAWKGGQSRELWQQAGKPAAPGRLNDLRHIIY 481
Cdd:COG4547  400 RDTVVTLLIDNSGSMRGRPITVAAICADILARTLERCGVKVEILGFTTRAWKGGQSREKWLAAGKPANPGRLNDLRHIIY 479

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 482 KPADVPWRRARKSLGLMLREGILKENIDGEALLWAHERLLGRNEDRRIMLVISDGAPVDDSTLSVNSGSYLERHLREVIA 561
Cdd:COG4547  480 KSADAPWRRARRNLGLMMREGLLKENIDGEALLWAHNRLLARPEQRRILMVISDGAPVDDSTLSVNPGNYLERHLRQVIE 559

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*....
gi 502811800 562 YIEGRSPIELLAIGIGHDVTRYYRRAVTITDVDQLGGAVVGQLTDLFDE 610
Cdd:COG4547  560 EIETRSPVELLAIGIGHDVTRYYRRAVTIVDAEELGGAMTEQLAELFDE 608
 
Name Accession Description Interval E-value
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 6-610 0e+00

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 977.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800   6 PKFDKEAQFLKSNAAALRAVAGVKECQVTYAGTDTHVGTDDVRLPALPPTATAAQKASLRGAADGAALWIAHHDPKTHKK 85
Cdd:COG4547    3 PKESPAEPFKRALAATLRAIAGDPELEVSFSADRPGLSGDRARLPEPPRRLTAEEVAIARGAADALALRLRHHDAALHAR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  86 HCPNPDGARAIFESAERARVEAIGANDLAGVGANLTAALNQRYETRQIEAPGSADEAGIAEVVRLLLREELTGAPPPQTL 165
Cdd:COG4547   83 LAPQGPEARAVFDALEQARVEALGARRMAGVAANLDAMLEDRYRRAGYARITDRADAPLADALALLVRERLTGRPPPPSA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 166 SMVMDLWRPWVKSRAGDLLDQLEANIDDQSQFAEISRRLIGALetDLGDASSNPDDDADEGSDEDDSGDSQSDQDGE-QS 244
Cdd:COG4547  163 RKLVDLWRDWIEEKAGADLDRLAELLDDQAAFARAVRDLLRDL--DLAEELGEDEDEEDEDDEDDSGEQEEDEEDGEdED 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 245 AVGEDQSEGDDSQSMDDAGDSGSSQEGEMGEADGAEEGMSDgDSPNSDMTGHNANRGTADD---SYRTFETKFDEIVSAA 321
Cdd:COG4547  241 EESDEGAEAEDAEASGDDAEEGESEAAEAESDEMAEEAEGE-DSEEPGEPWRPNAPPPDDPadpDYKVFTTAFDEVVAAE 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 322 DLCDPEELDRLRTMLDRHMENVTSVVGKLANRLQRKLMAHQNRSWDFDLEEGILDAAKLHRVVTQPLSALSYKQEQDTKF 401
Cdd:COG4547  320 DLCDPEELDRLRAYLDQQLAHLQGVVSRLANRLQRRLMAQQNRSWEFDLEEGILDAARLARVVADPTQPLSFKQEKDTEF 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 402 RDTVVTLLLDNSGSMRGRPITIAAVTADILARTLERCGVKVEILGFTTRAWKGGQSRELWQQAGKPAAPGRLNDLRHIIY 481
Cdd:COG4547  400 RDTVVTLLIDNSGSMRGRPITVAAICADILARTLERCGVKVEILGFTTRAWKGGQSREKWLAAGKPANPGRLNDLRHIIY 479

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 482 KPADVPWRRARKSLGLMLREGILKENIDGEALLWAHERLLGRNEDRRIMLVISDGAPVDDSTLSVNSGSYLERHLREVIA 561
Cdd:COG4547  480 KSADAPWRRARRNLGLMMREGLLKENIDGEALLWAHNRLLARPEQRRILMVISDGAPVDDSTLSVNPGNYLERHLRQVIE 559

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*....
gi 502811800 562 YIEGRSPIELLAIGIGHDVTRYYRRAVTITDVDQLGGAVVGQLTDLFDE 610
Cdd:COG4547  560 EIETRSPVELLAIGIGHDVTRYYRRAVTIVDAEELGGAMTEQLAELFDE 608
CobT TIGR01651
cobaltochelatase, CobT subunit; This model describes Pseudomonas denitrificans CobT gene ...
 14-611 0e+00

cobaltochelatase, CobT subunit; This model describes Pseudomonas denitrificans CobT gene product, which is a cobalt chelatase subunit that functions in cobalamin biosynthesis. Cobalamin (vitamin B12) can be synthesized via several pathways, including an aerobic pathway (found in Pseudomonas denitrificans) and an anaerobic pathway (found in P. shermanii and Salmonella typhimurium). These pathways differ in the point of cobalt insertion during corrin ring formation. There are apparently a number of variations on these two pathways, where the major differences seem to be concerned with the process of ring contraction. Confusion regarding the functions of enzymes found in the aerobic vs. anaerobic pathways has arisen because nonhomologous genes in these different pathways were given the same gene symbols. Thus, cobT in the aerobic pathway (P. denitrificans) is not a homolog of cobT in the anaerobic pathway (S. typhimurium). It should be noted that E. coli synthesizes cobalamin only when it is supplied with the precursor cobinamide, which is a complex intermediate. Additionally, all E. coli cobalamin synthesis genes (cobU, cobS and cobT) were named after their Salmonella typhimurium homologs which function in the anaerobic cobalamin synthesis pathway. This model describes the aerobic cobalamin pathway Pseudomonas denitrificans CobT gene product, which is a cobalt chelatase subunit, with a MW ~70 kDa. The aerobic pathway cobalt chelatase is a heterotrimeric, ATP-dependent enzyme that catalyzes cobalt insertion during cobalamin biosynthesis. The other two subunits are the P. denitrificans CobS (TIGR01650) and CobN (pfam02514 CobN/Magnesium Chelatase) proteins. To avoid potential confusion with the nonhomologous Salmonella typhimurium/E.coli cobT gene product, the P. denitrificans gene symbol is not used in the name of this model. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 130712 [Multi-domain]  Cd Length: 600  Bit Score: 712.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800   14 FLKSNAAALRAVAGVKECQVTYAGTDTHVGTDDVRLPALPPTATAAQKASLRGAADGAALWIAHHDPKTHKKHCPNPDGA 93
Cdd:TIGR01651   3 FKRALAHCARSIAGDPDLEVVFAGDRPQLLGNRARLPELPKDLSSREAARTRGLGDSMALRLACHDARIHARARPSGPDA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800   94 RAIFESAERARVEAIGANDLAGVGANLTAALNQRYETRQIEAPGSADEAGIAEVVRLLLREELTGAPPPQTLSMVMDLWR 173
Cdd:TIGR01651  83 RAIFDAVEQARVEAIGSNAMGGVAANLTAMLEAKYAKANLTVATDRADAPMAEALALMVREKLTGDAPPHSAKALVDLWR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  174 PWVKSRAGDLLDQLEANIDDQSQFAEISRRLIGALET--DLGDASsnPDDDADEGSDEDDSGDSQSDQDGEQSAvGEDQS 251
Cdd:TIGR01651 163 NDIEAKAGKDLDRLSAAIDDQQAFARVVREMLRSMELaeEMGDDT--ESEDEEDGDDDQPTENEQEEQGEGEGE-GQEGS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  252 EGDDSQSMDDAGDSG------SSQEGEMGEADGAEEGMSDGDSPNSDMTGHNAnrgtaDDSYRTFETKFDEIVSAADLCD 325
Cdd:TIGR01651 240 APQESEATDRESESGeeemvqSDQDDLPDESDDDSETPGEGARPARPFTSTGG-----EPDYKVFTTAFDETVDAEELCD 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  326 PEELDRLRTMLDRHMENVTSVVGKLANRLQRKLMAHQNRSWDFDLEEGILDAAKLHRVVTQPLSALSYKQEQDTKFRDTV 405
Cdd:TIGR01651 315 EEELDRLRAFLDKQLAALSGVVGRLANRLQRRLMAQQNRSWTFDLEEGYLDVARLTRVIIDPMQPLSFKQEEDTEFRDTV 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  406 VTLLLDNSGSMRGRPITIAAVTADILARTLERCGVKVEILGFTTRAWKGGQSRELWQQAGKPAAPGRLNDLRHIIYKPAD 485
Cdd:TIGR01651 395 VTLLIDNSGSMRGRPITVAATCADILARTLERCGVKVEILGFTTRAWKGGQSREKWLKAGKPAAPGRLNDLRHIIYKSAD 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  486 VPWRRARKSLGLMLREGILKENIDGEALLWAHERLLGRNEDRRIMLVISDGAPVDDSTLSVNSGSYLERHLREVIAYIEG 565
Cdd:TIGR01651 475 APWRRARRNLGLMMREGLLKENIDGEALMWAHQRLIARPEQRRILMMISDGAPVDDSTLSVNPGNYLERHLRAVIEEIET 554

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*.
gi 502811800  566 RSPIELLAIGIGHDVTRYYRRAVTITDVDQLGGAVVGQLTDLFDED 611
Cdd:TIGR01651 555 RSPVELLAIGIGHDVTRYYRRAVTIVDAEELAGAMTEQLAALFEEE 600
CobT_C pfam11775
Cobalamin biosynthesis protein CobT VWA domain; This family consists of several bacterial ...
 392-610 4.73e-110

Cobalamin biosynthesis protein CobT VWA domain; This family consists of several bacterial cobalamin biosynthesis (CobT) proteins. CobT is involved in the transformation of precorrin-3 into cobyrinic acid.


Pssm-ID: 288608 [Multi-domain]  Cd Length: 220  Bit Score: 329.68  E-value: 4.73e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  392 SYKQEQDTKFRDTVVTLLLDNSGSMRGRPITIAAVTADILARTLERCGVKVEILGFTTRAWKGGQSRELWQQAGKPAAPG 471
Cdd:pfam11775   1 SFMHEEDARARDACVQLLIDLSGSMGGRKIQLAAACADIIADALDRCGVKNEILGFTTFAWKGGPDREAMLAAGFPAFEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  472 RLNDLRHIIYKPADVPWRRARKSLGLMLREGILKENIDGEALLWAHERLLGRNEDRRIMLVISDGAPVDDSTLSVNSGSY 551
Cdd:pfam11775  81 LLLDIIHIINEKADAPEIRARKNLGCMCEEFLLKENIDGEALAQAAKLFAGRMEDKKILLMISDGAPCDDSTLSVAAGDG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  552 LERHLREVIAYIEGRSPIELLAIGIGHDVTR-YYRRAVTITDVDQLGGAVVGQLTDLFDE 610
Cdd:pfam11775 161 FEEHLRHIIEEIETLSDIDLIAIGIGHDAPRrYYKNAALINDAEELGGAITEELAEIFLE 220
vWA_norD_type cd01454
norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate ...
 404-582 2.10e-42

norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial denitrification has been established as NO3- ------> NO2- ------> NO -------> N2O ---------> N2. This reaction generally occurs under oxygen limiting conditions. Genetic and biochemical studies have shown that the first srep of the biochemical pathway is catalyzed by periplasmic nitrate reductases. This family is widely present in proteobacteria and firmicutes. This version of the domain is also present in some archaeal members. The function of the vWA domain in this sub-group is not known. Members of this subgroup have a conserved MIDAS motif.


Pssm-ID: 238731 [Multi-domain]  Cd Length: 174  Bit Score: 150.55  E-value: 2.10e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 404 TVVTLLLDNSGSMRG-RPITIAAVTADILARTLERCGVKVEILGFTTRAwkGGQSRELWQqagkpaAPGRLNDLRHiiyk 482
Cdd:cd01454    1 LAVTLLLDLSGSMRSdRRIDVAKKAAVLLAEALEACGVPHAILGFTTDA--GGRERVRWI------KIKDFDESLH---- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 483 padvpwRRARKSLGLMLREGilkENIDGEALLWAHERLLGRNEDRRIMLVISDGAPVDDSTLSVNSGsYLERHLREViay 562
Cdd:cd01454   69 ------ERARKRLAALSPGG---NTRDGAAIRHAAERLLARPEKRKILLVISDGEPNDLDYYEGNVF-ATEDALRAV--- 135

                        170       180
                 ....*....|....*....|.
gi 502811800 563 IEGRSP-IELLAIGIGHDVTR 582
Cdd:cd01454  136 IEARKLgIEVFGITIDRDATT 156
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
 406-580 1.01e-07

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 52.07  E-value: 1.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800   406 VTLLLDNSGSMRGRPITIAAVTADILARTLERC--GVKVEILGFTTRAwkggqsRELWqqagKPAAPGRLNDLRHIIykp 483
Cdd:smart00327   2 VVFLLDGSGSMGGNRFELAKEFVLKLVEQLDIGpdGDRVGLVTFSDDA------RVLF----PLNDSRSKDALLEAL--- 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800   484 ADVPWRRARkslGLMLREGILK--ENIdgeallwAHERLLGRNEDRRIMLVISDGAPVDDStlsvnsgsylERHLREVIA 561
Cdd:smart00327  69 ASLSYKLGG---GTNLGAALQYalENL-------FSKSAGSRRGAPKVVILITDGESNDGP----------KDLLKAAKE 128

                          170
                   ....*....|....*....
gi 502811800   562 YIegRSPIELLAIGIGHDV 580
Cdd:smart00327 129 LK--RSGVKVFVVGVGNDV 145
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-315 1.26e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 51.83  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGD---DSQSMDDAGDSGSSQEGEMGEADGAEEGMSDGDSPN 290
Cdd:NF033609 755 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsdsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 834

                         90       100
                 ....*....|....*....|....*
gi 502811800 291 SDMTGHNANRGTADDSYRTFETKFD 315
Cdd:NF033609 835 DSDSDSDSDSDSDSDSDSDSDSESD 859
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 2.54e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 50.68  E-value: 2.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGD-DSQSMDDAGDSGSSQEGEMGEADGAEEGMSDGDSPNSD 292
Cdd:NF033609 685 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 764

                         90
                 ....*....|....
gi 502811800 293 MTGHNANRGTADDS 306
Cdd:NF033609 765 DSDSDSDSDSDSDS 778
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 5.26e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.52  E-value: 5.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEmGEADGAEEGMSDGDSPNSDM 293
Cdd:NF033609 695 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSD 773

                         90
                 ....*....|...
gi 502811800 294 TGHNANRGTADDS 306
Cdd:NF033609 774 SDSDSDSDSDSDS 786
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 5.49e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.52  E-value: 5.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEmGEADGAEEGMSDGDSPNSDM 293
Cdd:NF033609 747 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSD 825

                         90
                 ....*....|...
gi 502811800 294 TGHNANRGTADDS 306
Cdd:NF033609 826 SDSDSDSDSDSDS 838
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 5.98e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.52  E-value: 5.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEM-GEADGAEEGMSDGDSPNSD 292
Cdd:NF033609 709 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDS 788

                         90
                 ....*....|....
gi 502811800 293 MTGHNANRGTADDS 306
Cdd:NF033609 789 DSDSDSDSDSDSDS 802
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 6.97e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.14  E-value: 6.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGD-DSQSMDDAGDSGSSQEGEMGEADGAEEGMSDGDSPNSD 292
Cdd:NF033609 699 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 778

                         90
                 ....*....|....
gi 502811800 293 MTGHNANRGTADDS 306
Cdd:NF033609 779 DSDSDSDSDSDSDS 792
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 9.41e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.75  E-value: 9.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEmGEADGAEEGMSDGDSPNSDM 293
Cdd:NF033609 655 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSD 733

                         90
                 ....*....|...
gi 502811800 294 TGHNANRGTADDS 306
Cdd:NF033609 734 SDSDSDSDSDSDS 746
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 1.15e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.75  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEmGEADGAEEGMSDGDSPNSDM 293
Cdd:NF033609 681 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSD 759

                         90
                 ....*....|...
gi 502811800 294 TGHNANRGTADDS 306
Cdd:NF033609 760 SDSDSDSDSDSDS 772
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 1.15e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.75  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEmGEADGAEEGMSDGDSPNSDM 293
Cdd:NF033609 707 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSD 785

                         90
                 ....*....|...
gi 502811800 294 TGHNANRGTADDS 306
Cdd:NF033609 786 SDSDSDSDSDSDS 798
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 1.77e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 47.98  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEgemGEADGAEEGMSDGDSPNSDM 293
Cdd:NF033609 679 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD---SDSDSDSDSDSDSDSDSDSD 755

                         90
                 ....*....|...
gi 502811800 294 TGHNANRGTADDS 306
Cdd:NF033609 756 SDSDSDSDSDSDS 768
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-315 1.85e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 47.98  E-value: 1.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEM-GEADGAEEGMSDGDSPNSD 292
Cdd:NF033609 589 DSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSdSDSDSDSDSDSDSDSDSDS 668

                         90       100
                 ....*....|....*....|...
gi 502811800 293 MTGHNANRGTADDSYRTFETKFD 315
Cdd:NF033609 669 DSDSDSDSDSDSDSDSDSDSDSD 691
PHA03169 PHA03169
hypothetical protein; Provisional
 209-287 2.24e-05

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 47.27  E-value: 2.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 209 ETDLGDASSNPD----------DDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEMGEaDG 278
Cdd:PHA03169 126 SSPESPASHSPPpsppshpgphEPAPPESHNPSPNQQPSSFLQPSHEDSPEEPEPPTSEPEPDSPGPPQSETPTSSP-PP 204


                 ....*....
gi 502811800 279 AEEGMSDGD 287
Cdd:PHA03169 205 QSPPDEPGE 213
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 206-306 1.78e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 44.90  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 206 GALETDLGDASSNPDDDADEGSDEDDSG-----DSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGE-MGEADGA 279
Cdd:NF033609 552 GEIEPIPEDSDSDPGSDSGSDSSNSDSGsdsgsDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDsASDSDSA 631

                         90       100
                 ....*....|....*....|....*..
gi 502811800 280 EEGMSDGDSPNSDMTGHNANRGTADDS 306
Cdd:NF033609 632 SDSDSASDSDSDSDSDSDSDSDSDSDS 658
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 206-315 1.22e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 42.20  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 206 GALETDLGDASSNPDDDADEGSDEDDSGDSQSDQDgeqSAVGEDQSEGDDSQSMDDAGDSGSSQEGEMGEADGAEEGMSD 285
Cdd:NF033609 583 GSDSTSDSGSDSASDSDSASDSDSASDSDSASDSD---SASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSD 659

                         90       100       110
                 ....*....|....*....|....*....|
gi 502811800 286 GDSPNSDMTGHNANRGTADDSYRTFETKFD 315
Cdd:NF033609 660 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 689
 
Name Accession Description Interval E-value
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 6-610 0e+00

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 977.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800   6 PKFDKEAQFLKSNAAALRAVAGVKECQVTYAGTDTHVGTDDVRLPALPPTATAAQKASLRGAADGAALWIAHHDPKTHKK 85
Cdd:COG4547    3 PKESPAEPFKRALAATLRAIAGDPELEVSFSADRPGLSGDRARLPEPPRRLTAEEVAIARGAADALALRLRHHDAALHAR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  86 HCPNPDGARAIFESAERARVEAIGANDLAGVGANLTAALNQRYETRQIEAPGSADEAGIAEVVRLLLREELTGAPPPQTL 165
Cdd:COG4547   83 LAPQGPEARAVFDALEQARVEALGARRMAGVAANLDAMLEDRYRRAGYARITDRADAPLADALALLVRERLTGRPPPPSA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 166 SMVMDLWRPWVKSRAGDLLDQLEANIDDQSQFAEISRRLIGALetDLGDASSNPDDDADEGSDEDDSGDSQSDQDGE-QS 244
Cdd:COG4547  163 RKLVDLWRDWIEEKAGADLDRLAELLDDQAAFARAVRDLLRDL--DLAEELGEDEDEEDEDDEDDSGEQEEDEEDGEdED 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 245 AVGEDQSEGDDSQSMDDAGDSGSSQEGEMGEADGAEEGMSDgDSPNSDMTGHNANRGTADD---SYRTFETKFDEIVSAA 321
Cdd:COG4547  241 EESDEGAEAEDAEASGDDAEEGESEAAEAESDEMAEEAEGE-DSEEPGEPWRPNAPPPDDPadpDYKVFTTAFDEVVAAE 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 322 DLCDPEELDRLRTMLDRHMENVTSVVGKLANRLQRKLMAHQNRSWDFDLEEGILDAAKLHRVVTQPLSALSYKQEQDTKF 401
Cdd:COG4547  320 DLCDPEELDRLRAYLDQQLAHLQGVVSRLANRLQRRLMAQQNRSWEFDLEEGILDAARLARVVADPTQPLSFKQEKDTEF 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 402 RDTVVTLLLDNSGSMRGRPITIAAVTADILARTLERCGVKVEILGFTTRAWKGGQSRELWQQAGKPAAPGRLNDLRHIIY 481
Cdd:COG4547  400 RDTVVTLLIDNSGSMRGRPITVAAICADILARTLERCGVKVEILGFTTRAWKGGQSREKWLAAGKPANPGRLNDLRHIIY 479

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 482 KPADVPWRRARKSLGLMLREGILKENIDGEALLWAHERLLGRNEDRRIMLVISDGAPVDDSTLSVNSGSYLERHLREVIA 561
Cdd:COG4547  480 KSADAPWRRARRNLGLMMREGLLKENIDGEALLWAHNRLLARPEQRRILMVISDGAPVDDSTLSVNPGNYLERHLRQVIE 559

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*....
gi 502811800 562 YIEGRSPIELLAIGIGHDVTRYYRRAVTITDVDQLGGAVVGQLTDLFDE 610
Cdd:COG4547  560 EIETRSPVELLAIGIGHDVTRYYRRAVTIVDAEELGGAMTEQLAELFDE 608
CobT TIGR01651
cobaltochelatase, CobT subunit; This model describes Pseudomonas denitrificans CobT gene ...
 14-611 0e+00

cobaltochelatase, CobT subunit; This model describes Pseudomonas denitrificans CobT gene product, which is a cobalt chelatase subunit that functions in cobalamin biosynthesis. Cobalamin (vitamin B12) can be synthesized via several pathways, including an aerobic pathway (found in Pseudomonas denitrificans) and an anaerobic pathway (found in P. shermanii and Salmonella typhimurium). These pathways differ in the point of cobalt insertion during corrin ring formation. There are apparently a number of variations on these two pathways, where the major differences seem to be concerned with the process of ring contraction. Confusion regarding the functions of enzymes found in the aerobic vs. anaerobic pathways has arisen because nonhomologous genes in these different pathways were given the same gene symbols. Thus, cobT in the aerobic pathway (P. denitrificans) is not a homolog of cobT in the anaerobic pathway (S. typhimurium). It should be noted that E. coli synthesizes cobalamin only when it is supplied with the precursor cobinamide, which is a complex intermediate. Additionally, all E. coli cobalamin synthesis genes (cobU, cobS and cobT) were named after their Salmonella typhimurium homologs which function in the anaerobic cobalamin synthesis pathway. This model describes the aerobic cobalamin pathway Pseudomonas denitrificans CobT gene product, which is a cobalt chelatase subunit, with a MW ~70 kDa. The aerobic pathway cobalt chelatase is a heterotrimeric, ATP-dependent enzyme that catalyzes cobalt insertion during cobalamin biosynthesis. The other two subunits are the P. denitrificans CobS (TIGR01650) and CobN (pfam02514 CobN/Magnesium Chelatase) proteins. To avoid potential confusion with the nonhomologous Salmonella typhimurium/E.coli cobT gene product, the P. denitrificans gene symbol is not used in the name of this model. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 130712 [Multi-domain]  Cd Length: 600  Bit Score: 712.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800   14 FLKSNAAALRAVAGVKECQVTYAGTDTHVGTDDVRLPALPPTATAAQKASLRGAADGAALWIAHHDPKTHKKHCPNPDGA 93
Cdd:TIGR01651   3 FKRALAHCARSIAGDPDLEVVFAGDRPQLLGNRARLPELPKDLSSREAARTRGLGDSMALRLACHDARIHARARPSGPDA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800   94 RAIFESAERARVEAIGANDLAGVGANLTAALNQRYETRQIEAPGSADEAGIAEVVRLLLREELTGAPPPQTLSMVMDLWR 173
Cdd:TIGR01651  83 RAIFDAVEQARVEAIGSNAMGGVAANLTAMLEAKYAKANLTVATDRADAPMAEALALMVREKLTGDAPPHSAKALVDLWR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  174 PWVKSRAGDLLDQLEANIDDQSQFAEISRRLIGALET--DLGDASsnPDDDADEGSDEDDSGDSQSDQDGEQSAvGEDQS 251
Cdd:TIGR01651 163 NDIEAKAGKDLDRLSAAIDDQQAFARVVREMLRSMELaeEMGDDT--ESEDEEDGDDDQPTENEQEEQGEGEGE-GQEGS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  252 EGDDSQSMDDAGDSG------SSQEGEMGEADGAEEGMSDGDSPNSDMTGHNAnrgtaDDSYRTFETKFDEIVSAADLCD 325
Cdd:TIGR01651 240 APQESEATDRESESGeeemvqSDQDDLPDESDDDSETPGEGARPARPFTSTGG-----EPDYKVFTTAFDETVDAEELCD 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  326 PEELDRLRTMLDRHMENVTSVVGKLANRLQRKLMAHQNRSWDFDLEEGILDAAKLHRVVTQPLSALSYKQEQDTKFRDTV 405
Cdd:TIGR01651 315 EEELDRLRAFLDKQLAALSGVVGRLANRLQRRLMAQQNRSWTFDLEEGYLDVARLTRVIIDPMQPLSFKQEEDTEFRDTV 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  406 VTLLLDNSGSMRGRPITIAAVTADILARTLERCGVKVEILGFTTRAWKGGQSRELWQQAGKPAAPGRLNDLRHIIYKPAD 485
Cdd:TIGR01651 395 VTLLIDNSGSMRGRPITVAATCADILARTLERCGVKVEILGFTTRAWKGGQSREKWLKAGKPAAPGRLNDLRHIIYKSAD 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  486 VPWRRARKSLGLMLREGILKENIDGEALLWAHERLLGRNEDRRIMLVISDGAPVDDSTLSVNSGSYLERHLREVIAYIEG 565
Cdd:TIGR01651 475 APWRRARRNLGLMMREGLLKENIDGEALMWAHQRLIARPEQRRILMMISDGAPVDDSTLSVNPGNYLERHLRAVIEEIET 554

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*.
gi 502811800  566 RSPIELLAIGIGHDVTRYYRRAVTITDVDQLGGAVVGQLTDLFDED 611
Cdd:TIGR01651 555 RSPVELLAIGIGHDVTRYYRRAVTIVDAEELAGAMTEQLAALFEEE 600
CobT_C pfam11775
Cobalamin biosynthesis protein CobT VWA domain; This family consists of several bacterial ...
 392-610 4.73e-110

Cobalamin biosynthesis protein CobT VWA domain; This family consists of several bacterial cobalamin biosynthesis (CobT) proteins. CobT is involved in the transformation of precorrin-3 into cobyrinic acid.


Pssm-ID: 288608 [Multi-domain]  Cd Length: 220  Bit Score: 329.68  E-value: 4.73e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  392 SYKQEQDTKFRDTVVTLLLDNSGSMRGRPITIAAVTADILARTLERCGVKVEILGFTTRAWKGGQSRELWQQAGKPAAPG 471
Cdd:pfam11775   1 SFMHEEDARARDACVQLLIDLSGSMGGRKIQLAAACADIIADALDRCGVKNEILGFTTFAWKGGPDREAMLAAGFPAFEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  472 RLNDLRHIIYKPADVPWRRARKSLGLMLREGILKENIDGEALLWAHERLLGRNEDRRIMLVISDGAPVDDSTLSVNSGSY 551
Cdd:pfam11775  81 LLLDIIHIINEKADAPEIRARKNLGCMCEEFLLKENIDGEALAQAAKLFAGRMEDKKILLMISDGAPCDDSTLSVAAGDG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  552 LERHLREVIAYIEGRSPIELLAIGIGHDVTR-YYRRAVTITDVDQLGGAVVGQLTDLFDE 610
Cdd:pfam11775 161 FEEHLRHIIEEIETLSDIDLIAIGIGHDAPRrYYKNAALINDAEELGGAITEELAEIFLE 220
CobT pfam06213
Cobalamin biosynthesis protein CobT; This family consists of several bacterial cobalamin ...
 14-277 3.44e-73

Cobalamin biosynthesis protein CobT; This family consists of several bacterial cobalamin biosynthesis (CobT) proteins. CobT is involved in the transformation of precorrin-3 into cobyrinic acid.


Pssm-ID: 428829  Cd Length: 274  Bit Score: 235.97  E-value: 3.44e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800   14 FLKSNAAALRAVAGVKECQVTYAGTDTHVGTDDVRLPALPPTATAAQKASLRGAADGAALWIAHHDPKTHKKHCPNPDGA 93
Cdd:pfam06213   7 FKRALAGAVRAIAGDPELEVAFSADPPGLSGDRARLPQPPRKLTAEEVARARGFADSLALRLRHHDAAVHARYAPAGPAA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800   94 RAIFESAERARVEAIGANDLAGVGANLTAALNQRYETRQIEAPGSADEAGIAEVVRLLLREELTGAPPPQTLSMVMDLWR 173
Cdd:pfam06213  87 RAAYDALEQARVEALGARRMAGVAANLDAALEDRYRRAGYDRATSRADAPLAEALALLVRERLTGQPPPAAARHVVDLWR 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  174 PWVKSRAGDLLDQLEANIDDQSQFAEISRRLIGALE--TDLGDASSNPDDDA--DEGSDEDDSGDSQSDQDGEQSAvGED 249
Cdd:pfam06213 167 PWIEEKAGADLDRLAEALDDQAAFARAARDLLTDLDlgDELGDDPEDDDDEEeeDDGEDDEESEDEEEEGEDDDQE-EQA 245

                         250       260
                  ....*....|....*....|....*...
gi 502811800  250 QSEGDDSQSMDDAGDSGSSQEGEMGEAD 277
Cdd:pfam06213 246 EAAAEESEGEGDDGESGESEADDAADGD 273
vWA_norD_type cd01454
norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate ...
 404-582 2.10e-42

norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial denitrification has been established as NO3- ------> NO2- ------> NO -------> N2O ---------> N2. This reaction generally occurs under oxygen limiting conditions. Genetic and biochemical studies have shown that the first srep of the biochemical pathway is catalyzed by periplasmic nitrate reductases. This family is widely present in proteobacteria and firmicutes. This version of the domain is also present in some archaeal members. The function of the vWA domain in this sub-group is not known. Members of this subgroup have a conserved MIDAS motif.


Pssm-ID: 238731 [Multi-domain]  Cd Length: 174  Bit Score: 150.55  E-value: 2.10e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 404 TVVTLLLDNSGSMRG-RPITIAAVTADILARTLERCGVKVEILGFTTRAwkGGQSRELWQqagkpaAPGRLNDLRHiiyk 482
Cdd:cd01454    1 LAVTLLLDLSGSMRSdRRIDVAKKAAVLLAEALEACGVPHAILGFTTDA--GGRERVRWI------KIKDFDESLH---- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 483 padvpwRRARKSLGLMLREGilkENIDGEALLWAHERLLGRNEDRRIMLVISDGAPVDDSTLSVNSGsYLERHLREViay 562
Cdd:cd01454   69 ------ERARKRLAALSPGG---NTRDGAAIRHAAERLLARPEKRKILLVISDGEPNDLDYYEGNVF-ATEDALRAV--- 135

                        170       180
                 ....*....|....*....|.
gi 502811800 563 IEGRSP-IELLAIGIGHDVTR 582
Cdd:cd01454  136 IEARKLgIEVFGITIDRDATT 156
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
 406-580 1.01e-07

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 52.07  E-value: 1.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800   406 VTLLLDNSGSMRGRPITIAAVTADILARTLERC--GVKVEILGFTTRAwkggqsRELWqqagKPAAPGRLNDLRHIIykp 483
Cdd:smart00327   2 VVFLLDGSGSMGGNRFELAKEFVLKLVEQLDIGpdGDRVGLVTFSDDA------RVLF----PLNDSRSKDALLEAL--- 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800   484 ADVPWRRARkslGLMLREGILK--ENIdgeallwAHERLLGRNEDRRIMLVISDGAPVDDStlsvnsgsylERHLREVIA 561
Cdd:smart00327  69 ASLSYKLGG---GTNLGAALQYalENL-------FSKSAGSRRGAPKVVILITDGESNDGP----------KDLLKAAKE 128

                          170
                   ....*....|....*....
gi 502811800   562 YIegRSPIELLAIGIGHDV 580
Cdd:smart00327 129 LK--RSGVKVFVVGVGNDV 145
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-315 1.26e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 51.83  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGD---DSQSMDDAGDSGSSQEGEMGEADGAEEGMSDGDSPN 290
Cdd:NF033609 755 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsdsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 834

                         90       100
                 ....*....|....*....|....*
gi 502811800 291 SDMTGHNANRGTADDSYRTFETKFD 315
Cdd:NF033609 835 DSDSDSDSDSDSDSDSDSDSDSESD 859
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 2.54e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 50.68  E-value: 2.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGD-DSQSMDDAGDSGSSQEGEMGEADGAEEGMSDGDSPNSD 292
Cdd:NF033609 685 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 764

                         90
                 ....*....|....
gi 502811800 293 MTGHNANRGTADDS 306
Cdd:NF033609 765 DSDSDSDSDSDSDS 778
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 5.26e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.52  E-value: 5.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEmGEADGAEEGMSDGDSPNSDM 293
Cdd:NF033609 695 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSD 773

                         90
                 ....*....|...
gi 502811800 294 TGHNANRGTADDS 306
Cdd:NF033609 774 SDSDSDSDSDSDS 786
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 5.49e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.52  E-value: 5.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEmGEADGAEEGMSDGDSPNSDM 293
Cdd:NF033609 747 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSD 825

                         90
                 ....*....|...
gi 502811800 294 TGHNANRGTADDS 306
Cdd:NF033609 826 SDSDSDSDSDSDS 838
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 5.98e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.52  E-value: 5.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEM-GEADGAEEGMSDGDSPNSD 292
Cdd:NF033609 709 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDS 788

                         90
                 ....*....|....
gi 502811800 293 MTGHNANRGTADDS 306
Cdd:NF033609 789 DSDSDSDSDSDSDS 802
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 6.97e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.14  E-value: 6.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGD-DSQSMDDAGDSGSSQEGEMGEADGAEEGMSDGDSPNSD 292
Cdd:NF033609 699 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 778

                         90
                 ....*....|....
gi 502811800 293 MTGHNANRGTADDS 306
Cdd:NF033609 779 DSDSDSDSDSDSDS 792
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 9.41e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.75  E-value: 9.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEmGEADGAEEGMSDGDSPNSDM 293
Cdd:NF033609 655 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSD 733

                         90
                 ....*....|...
gi 502811800 294 TGHNANRGTADDS 306
Cdd:NF033609 734 SDSDSDSDSDSDS 746
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 1.15e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.75  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEmGEADGAEEGMSDGDSPNSDM 293
Cdd:NF033609 681 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSD 759

                         90
                 ....*....|...
gi 502811800 294 TGHNANRGTADDS 306
Cdd:NF033609 760 SDSDSDSDSDSDS 772
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 1.15e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.75  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEmGEADGAEEGMSDGDSPNSDM 293
Cdd:NF033609 707 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSD 785

                         90
                 ....*....|...
gi 502811800 294 TGHNANRGTADDS 306
Cdd:NF033609 786 SDSDSDSDSDSDS 798
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-306 1.77e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 47.98  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEgemGEADGAEEGMSDGDSPNSDM 293
Cdd:NF033609 679 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD---SDSDSDSDSDSDSDSDSDSD 755

                         90
                 ....*....|...
gi 502811800 294 TGHNANRGTADDS 306
Cdd:NF033609 756 SDSDSDSDSDSDS 768
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 214-315 1.85e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 47.98  E-value: 1.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEM-GEADGAEEGMSDGDSPNSD 292
Cdd:NF033609 589 DSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSdSDSDSDSDSDSDSDSDSDS 668

                         90       100
                 ....*....|....*....|...
gi 502811800 293 MTGHNANRGTADDSYRTFETKFD 315
Cdd:NF033609 669 DSDSDSDSDSDSDSDSDSDSDSD 691
PHA03169 PHA03169
hypothetical protein; Provisional
 209-287 2.24e-05

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 47.27  E-value: 2.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 209 ETDLGDASSNPD----------DDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEMGEaDG 278
Cdd:PHA03169 126 SSPESPASHSPPpsppshpgphEPAPPESHNPSPNQQPSSFLQPSHEDSPEEPEPPTSEPEPDSPGPPQSETPTSSP-PP 204


                 ....*....
gi 502811800 279 AEEGMSDGD 287
Cdd:PHA03169 205 QSPPDEPGE 213
NorD COG4548
Nitric oxide reductase activation protein [Inorganic ion transport and metabolism];
395-540 3.41e-05

Nitric oxide reductase activation protein [Inorganic ion transport and metabolism];


Pssm-ID: 443612 [Multi-domain]  Cd Length: 439  Bit Score: 46.63  E-value: 3.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 395 QEQDTKFRDTVVTLLLDNSGSMRG------RPITIAAVTADILARTLERCGVKVEILGFTTRawkggqsrelwqqagkpa 468
Cdd:COG4548  240 MRRRRKERDLAVLLLLDLSLSTDAwvgsgrRVLDVEREALLLLAEALEALGDPFAIYGFSSD------------------ 301

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502811800 469 apGRlNDLRHIIYKPADVPW-RRARKSLGLMlrEGILkENIDGEALLWAHERLLGRNEDRRIMLVISDGAPVD 540
Cdd:COG4548  302 --GR-HRVRYYRIKDFDEPYdDAVRARIAGL--EPGY-YTRMGAAIRHATALLAAQPARRRLLLVLTDGKPND 368
DNA_pol_phi pfam04931
DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7. ...
 183-283 1.41e-04

DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.


Pssm-ID: 461488  Cd Length: 765  Bit Score: 44.92  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  183 LLDQLEANiDDQSQFAEisrrligaLETDLGDASSnpDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDS------ 256
Cdd:pfam04931 619 LLDVLDAR-ENPEGQQE--------LFEDEDEDEE--DDDEEEDDDDEDDEDSEEDDDEDDDDEDEEDDDDEDVdeidel 687

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 502811800  257 ---------QSMDDAGDSGSSQEGEMGEadgaEEGM 283
Cdd:pfam04931 688 raklaealgEHGDDADDDDSDSDEDMDD----EQMM 719
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 206-306 1.78e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 44.90  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 206 GALETDLGDASSNPDDDADEGSDEDDSG-----DSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGE-MGEADGA 279
Cdd:NF033609 552 GEIEPIPEDSDSDPGSDSGSDSSNSDSGsdsgsDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDsASDSDSA 631

                         90       100
                 ....*....|....*....|....*..
gi 502811800 280 EEGMSDGDSPNSDMTGHNANRGTADDS 306
Cdd:NF033609 632 SDSDSASDSDSDSDSDSDSDSDSDSDS 658
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 173-322 5.00e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.45  E-value: 5.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800   173 RPWVKSRA-GDL----LDQLEANIDDQSQFAEISRRLIGALETDLGDASSNPDDDADEGSDEDDsGDSQSDQDGEQSAVG 247
Cdd:TIGR00927  619 RPVAKVMAlGDLskgdVAEAEHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESE-GEIPAERKGEQEGEG 697

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800   248 EDQSEGDDSQSMDDAGDSGSSQEGEM------GEADGAEEGMSDGDSPNSDMTGHNANRGTADDSYRTFETKFDEIVSAA 321
Cdd:TIGR00927  698 EIEAKEADHKGETEAEEVEHEGETEAegtedeGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKED 777


                   .
gi 502811800   322 D 322
Cdd:TIGR00927  778 E 778
SEEEED pfam14797
Serine-rich region of AP3B1, clathrin-adaptor complex; This short low-complexity, highly ...
 224-306 6.79e-04

Serine-rich region of AP3B1, clathrin-adaptor complex; This short low-complexity, highly serine-rich region lies on clathrin-adaptor complex 3 beta-1 subunit proteins, between family Adaptin_N, pfam01602 and a C-terminal domain, AP3B1_C,pfam14796.


Pssm-ID: 434218 [Multi-domain]  Cd Length: 111  Bit Score: 39.53  E-value: 6.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  224 DEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSqSMDDAGDSGSSQEGEMG---EADGAEEGMSD--GDSPNSDMTGHNA 298
Cdd:pfam14797   7 SESEEEEDSSDSSSDSESESGSESEEEGKEGSS-SEDSSEDSSSEQESESGsesEKKRTAKRNSKakGKSDSEDGEKKNE 85


                  ....*...
gi 502811800  299 NRGTADDS 306
Cdd:pfam14797  86 KSKTSDSS 93
PTZ00482 PTZ00482
membrane-attack complex/perforin (MACPF) Superfamily; Provisional
 180-306 9.71e-04

membrane-attack complex/perforin (MACPF) Superfamily; Provisional


Pssm-ID: 240433 [Multi-domain]  Cd Length: 844  Bit Score: 42.16  E-value: 9.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 180 AGDLLDQLEANIDDQSQFAEISRRL-------IGAL----ETDLGDASS----------NPDDDADEGSDE--------- 229
Cdd:PTZ00482  62 ANILYNSILCNQKKHASFLNQRKSLddddddeFDFLyeddEDDAGNATSgesstdddslLELPDRDEDADTqanndqtnd 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 230 ---DDSGDSQSDQDGEQS---AVGEDQSEGDDSQSMDDAGDSGSSQEGEMGEADgaeegmSDGDSPNSDMTGHNANRGTA 303
Cdd:PTZ00482 142 fdqDDSSNSQTDQGLKQSvnlSSAEKLIEEKKGQTENTFKFYNFGNDGEEAAAK------DGGKSKSSDPGPLNDSDGQG 215


                 ...
gi 502811800 304 DDS 306
Cdd:PTZ00482 216 DDG 218
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 206-315 1.22e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 42.20  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 206 GALETDLGDASSNPDDDADEGSDEDDSGDSQSDQDgeqSAVGEDQSEGDDSQSMDDAGDSGSSQEGEMGEADGAEEGMSD 285
Cdd:NF033609 583 GSDSTSDSGSDSASDSDSASDSDSASDSDSASDSD---SASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSD 659

                         90       100       110
                 ....*....|....*....|....*....|
gi 502811800 286 GDSPNSDMTGHNANRGTADDSYRTFETKFD 315
Cdd:NF033609 660 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 689
PHA03169 PHA03169
hypothetical protein; Provisional
 222-295 1.29e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 41.49  E-value: 1.29e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502811800 222 DADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGS----SQEGEMGEADGAEEGMSDGDSPNSDMTG 295
Cdd:PHA03169  92 PSGSGSESVGSPTPSPSGSAEELASGLSPENTSGSSPESPASHSPPpsppSHPGPHEPAPPESHNPSPNQQPSSFLQP 169
PHA02664 PHA02664
hypothetical protein; Provisional
 214-281 3.35e-03

hypothetical protein; Provisional


Pssm-ID: 177447  Cd Length: 534  Bit Score: 40.37  E-value: 3.35e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502811800 214 DASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDS--QSMDDAGDSGSSQE----GEMGEADGAEE 281
Cdd:PHA02664 448 DRADSDEDDMDEQESGDERADGEDDSDSSYSYSTTSSEDESDSadDSWGDESDSGIEHDdggvGQAIEEEEEEE 521
PHA03169 PHA03169
hypothetical protein; Provisional
 217-304 4.59e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 39.95  E-value: 4.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 217 SNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDsgSSQEGEMGEADGAEEGMSDGDSPNSDMTGH 296
Cdd:PHA03169 126 SSPESPASHSPPPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQPSHED--SPEEPEPPTSEPEPDSPGPPQSETPTSSPP 203


                 ....*...
gi 502811800 297 NANRGTAD 304
Cdd:PHA03169 204 PQSPPDEP 211
DUF5059 pfam16502
Domain of unknown function (DUF5059); This domain is found fused to a copper-binding protein ...
 207-327 4.96e-03

Domain of unknown function (DUF5059); This domain is found fused to a copper-binding protein at the C-terminus, family Copper-bind, pfam00127. Its function is not known, and it is found in the Halobacteriaceae family in Archaea.


Pssm-ID: 406814  Cd Length: 620  Bit Score: 39.81  E-value: 4.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800  207 ALETDLGDASSNPDD-DADEGSDEDDSGdSQSDQDGEQSAVGEDQSEGDDSQSM-DDAGDSGSSqeGEMGEADGAEEGMS 284
Cdd:pfam16502  62 GFEEALGGLRSALSEgDIDRAREAAVQA-SDNLLAAQQALVGETATDALDALLFgSRAADARML--AAAGAFDAAATVAN 138

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 502811800  285 DGDSPNSDMTGHNANRGTADDSYRTFETKFDEIVSAADLCDPE 327
Cdd:pfam16502 139 EALEAFEDAPVHSAIESADGEAYEAFESGLEGILSAAGEGDAE 181
POB3 COG5165
Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, ...
 178-289 6.78e-03

Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics];


Pssm-ID: 227494 [Multi-domain]  Cd Length: 508  Bit Score: 39.22  E-value: 6.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 178 SRAGDLLDQLEANidDQSQFAEISRRLIGALETDL-GDASSNPDDDADEGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDS 256
Cdd:COG5165  400 ARTFDLTLFLRSP--GSYTFNNISKDEQGALEQFLhSKGIKARNEEVQERLQTDLGSISDSEDINMGSAGEEDESEDEDF 477

                         90       100       110
                 ....*....|....*....|....*....|...
gi 502811800 257 QSmddAGDSGSSQEGEMGEADGAEEGMSDGDSP 289
Cdd:COG5165  478 QM---VSDSDVAEEYDLQAALSDAEGGSDEERP 507
PHA03169 PHA03169
hypothetical protein; Provisional
 225-306 7.72e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 39.18  E-value: 7.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502811800 225 EGSDEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEMGEADGAEEGMSDGDSPNSDMTGHNANRGTAD 304
Cdd:PHA03169  89 QGGPSGSGSESVGSPTPSPSGSAEELASGLSPENTSGSSPESPASHSPPPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQ 168


                 ..
gi 502811800 305 DS 306
Cdd:PHA03169 169 PS 170
PHA02664 PHA02664
hypothetical protein; Provisional
 214-287 8.43e-03

hypothetical protein; Provisional


Pssm-ID: 177447  Cd Length: 534  Bit Score: 39.21  E-value: 8.43e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502811800 214 DASSNPDDDADEGS-DEDDSGDSQSDQDGEQSAVGEDQSEGDDSQSMDDAGDSGSSQEGEMGE---ADGAEEGMSDGD 287
Cdd:PHA02664 430 EAEAHDEFDQDPGApAHADRADSDEDDMDEQESGDERADGEDDSDSSYSYSTTSSEDESDSADdswGDESDSGIEHDD 507
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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