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Conserved domains on  [gi|502788794|ref|WP_013023770|]
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MULTISPECIES: DUF4268 domain-containing protein [Enterobacterales]

Protein Classification

DUF4268 domain-containing protein( domain architecture ID 15750490)

DUF4268 domain-containing protein may also contain a partial endonuclease NucS domain at the N-terminal region

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4268 pfam14088
Domain of unknown function (DUF4268); This family of proteins is functionally uncharacterized. ...
 238-372 1.04e-36

Domain of unknown function (DUF4268); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 151 and 387 amino acids in length.


:

Pssm-ID: 404896  Cd Length: 138  Bit Score: 130.14  E-value: 1.04e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502788794  238 LRREFWSLALEKFRTSTCslfNNRAPTTDHWLAAGSGVSGVPFEVIFSQKDARIQLNISRSDAVENTWLFERLSERKTHI 317
Cdd:pfam14088   1 LRLEFWTAFLEYLKERPS---ANGKPSPDHWINYGTGISGVSFKFVADRDKARVELYIDHKDEEENKELFEQLLELKDEI 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 502788794  318 ESQFGGMLNWRLLPERKSCQVVCAKAFDGG----NKELWPDIISWMIDGMTRLEKAIRP 372
Cdd:pfam14088  78 EEEFGEELEWDRLDDKKASRISRIYVELKDvnifDKEDWPEIIDWLIERMIKLEKAFKP 136
NucS super family cl43475
Endonuclease NucS, RecB family [Replication, recombination and repair];
26-142 1.02e-17

Endonuclease NucS, RecB family [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG1637:

Pssm-ID: 441244  Cd Length: 209  Bit Score: 81.07  E-value: 1.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502788794  26 ERDHLQEWLANNPQALtkkddkEDELLIIQKEFAgfdETNERLDLLAIDKKGNLVIIENKLDDSGRDVVWQALKYAGYCA 105
Cdd:COG1637  103 VEADLQELLAENPELI------EEGFRLIRREYP---TAIGPVDLLARDADGNLVVIELKRRRAGIDAVEQLTRYVELLN 173

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 502788794 106 NLRQ-ESVVEIFQLYltqhepsEIRPAAEVIAEFMGWE 142
Cdd:COG1637  174 RDPLlAPVRGILVAP-------SITPQARTLLEDRGLE 204
 
Name Accession Description Interval E-value
DUF4268 pfam14088
Domain of unknown function (DUF4268); This family of proteins is functionally uncharacterized. ...
 238-372 1.04e-36

Domain of unknown function (DUF4268); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 151 and 387 amino acids in length.


Pssm-ID: 404896  Cd Length: 138  Bit Score: 130.14  E-value: 1.04e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502788794  238 LRREFWSLALEKFRTSTCslfNNRAPTTDHWLAAGSGVSGVPFEVIFSQKDARIQLNISRSDAVENTWLFERLSERKTHI 317
Cdd:pfam14088   1 LRLEFWTAFLEYLKERPS---ANGKPSPDHWINYGTGISGVSFKFVADRDKARVELYIDHKDEEENKELFEQLLELKDEI 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 502788794  318 ESQFGGMLNWRLLPERKSCQVVCAKAFDGG----NKELWPDIISWMIDGMTRLEKAIRP 372
Cdd:pfam14088  78 EEEFGEELEWDRLDDKKASRISRIYVELKDvnifDKEDWPEIIDWLIERMIKLEKAFKP 136
NucS COG1637
Endonuclease NucS, RecB family [Replication, recombination and repair];
26-142 1.02e-17

Endonuclease NucS, RecB family [Replication, recombination and repair];


Pssm-ID: 441244  Cd Length: 209  Bit Score: 81.07  E-value: 1.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502788794  26 ERDHLQEWLANNPQALtkkddkEDELLIIQKEFAgfdETNERLDLLAIDKKGNLVIIENKLDDSGRDVVWQALKYAGYCA 105
Cdd:COG1637  103 VEADLQELLAENPELI------EEGFRLIRREYP---TAIGPVDLLARDADGNLVVIELKRRRAGIDAVEQLTRYVELLN 173

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 502788794 106 NLRQ-ESVVEIFQLYltqhepsEIRPAAEVIAEFMGWE 142
Cdd:COG1637  174 RDPLlAPVRGILVAP-------SITPQARTLLEDRGLE 204
NucS-like cd22341
Mismatch restriction endonuclease NucS and similar nucleases; Archaeal mismatch restriction ...
 21-103 1.93e-12

Mismatch restriction endonuclease NucS and similar nucleases; Archaeal mismatch restriction endonuclease NucS and its ortholog EndoMS specifically cleave dsDNA containing mismatched bases. They belong to a superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.


Pssm-ID: 411745 [Multi-domain]  Cd Length: 237  Bit Score: 66.27  E-value: 1.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502788794  21 SLGFRERDhLQEWLANNPQALtkkddkEDELLIIQKEFAGfdeTNERLDLLAIDKKGNLVIIENKLDDSGRDVVWQALKY 100
Cdd:cd22341  123 ELGGLEKD-LEDYLARNPELI------EEGLRIIGREYPT---PVGRIDILAKDKDGNLVVIELKRGRADDRAVGQLLRY 192


                 ...
gi 502788794 101 AGY 103
Cdd:cd22341  193 MGW 195
 
Name Accession Description Interval E-value
DUF4268 pfam14088
Domain of unknown function (DUF4268); This family of proteins is functionally uncharacterized. ...
 238-372 1.04e-36

Domain of unknown function (DUF4268); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 151 and 387 amino acids in length.


Pssm-ID: 404896  Cd Length: 138  Bit Score: 130.14  E-value: 1.04e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502788794  238 LRREFWSLALEKFRTSTCslfNNRAPTTDHWLAAGSGVSGVPFEVIFSQKDARIQLNISRSDAVENTWLFERLSERKTHI 317
Cdd:pfam14088   1 LRLEFWTAFLEYLKERPS---ANGKPSPDHWINYGTGISGVSFKFVADRDKARVELYIDHKDEEENKELFEQLLELKDEI 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 502788794  318 ESQFGGMLNWRLLPERKSCQVVCAKAFDGG----NKELWPDIISWMIDGMTRLEKAIRP 372
Cdd:pfam14088  78 EEEFGEELEWDRLDDKKASRISRIYVELKDvnifDKEDWPEIIDWLIERMIKLEKAFKP 136
NucS COG1637
Endonuclease NucS, RecB family [Replication, recombination and repair];
26-142 1.02e-17

Endonuclease NucS, RecB family [Replication, recombination and repair];


Pssm-ID: 441244  Cd Length: 209  Bit Score: 81.07  E-value: 1.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502788794  26 ERDHLQEWLANNPQALtkkddkEDELLIIQKEFAgfdETNERLDLLAIDKKGNLVIIENKLDDSGRDVVWQALKYAGYCA 105
Cdd:COG1637  103 VEADLQELLAENPELI------EEGFRLIRREYP---TAIGPVDLLARDADGNLVVIELKRRRAGIDAVEQLTRYVELLN 173

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 502788794 106 NLRQ-ESVVEIFQLYltqhepsEIRPAAEVIAEFMGWE 142
Cdd:COG1637  174 RDPLlAPVRGILVAP-------SITPQARTLLEDRGLE 204
NucS-like cd22341
Mismatch restriction endonuclease NucS and similar nucleases; Archaeal mismatch restriction ...
 21-103 1.93e-12

Mismatch restriction endonuclease NucS and similar nucleases; Archaeal mismatch restriction endonuclease NucS and its ortholog EndoMS specifically cleave dsDNA containing mismatched bases. They belong to a superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.


Pssm-ID: 411745 [Multi-domain]  Cd Length: 237  Bit Score: 66.27  E-value: 1.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502788794  21 SLGFRERDhLQEWLANNPQALtkkddkEDELLIIQKEFAGfdeTNERLDLLAIDKKGNLVIIENKLDDSGRDVVWQALKY 100
Cdd:cd22341  123 ELGGLEKD-LEDYLARNPELI------EEGLRIIGREYPT---PVGRIDILAKDKDGNLVVIELKRGRADDRAVGQLLRY 192


                 ...
gi 502788794 101 AGY 103
Cdd:cd22341  193 MGW 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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