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Conserved domains on  [gi|502775092|ref|WP_013010068|]
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phosphopyruvate hydratase [Denitrovibrio acetiphilus]

Protein Classification

phosphopyruvate hydratase( domain architecture ID 11414960)

phosphopyruvate hydratase (enolase) catalyzes the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
1-429 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 911.32  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092   1 MTDIIDVFAREVLDSRGNPTIEVEVVTSGGVMGRAIVPSGASTGEYEAVELRDGDKERFLGKGVLQAVQNVNEIVAPELE 80
Cdd:COG0148    1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  81 GIDVTEQKLIDEMLIELDGTKNKGKLGANAILGVSLACAKAAAESCGLPLYKYIGGAYACTLPAPMMNILNGGEHADNNV 160
Cdd:COG0148   81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 161 DIQEFMIMPLGAESFREALRMGVEVFHTLKGVLKAKGMSTSVGDEGGFAPNLGSNEEAIEVILEAIDKAGYKAGSDIYIA 240
Cdd:COG0148  161 DIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIALA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 241 IDAASSEFYnkDKGVYVLEAEAEpEKTSAQMVEYYKYLVEKYPIISIEDGLDENDWDGWKLLTDAIGDKCQLVGDDLFVT 320
Cdd:COG0148  241 LDVAASEFY--KDGKYHLKGEGK-ELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVT 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 321 NTERLTRGIKTGVANSILVKLNQIGTLTETLDAIQTAREAGYTCVISHRSGESEDTTIADLAVAVNAGQIKTGSACRTDR 400
Cdd:COG0148  318 NPKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSER 397
                        410       420
                 ....*....|....*....|....*....
gi 502775092 401 IAKYNQLLRIEEELFDQAAYKGLGAFYNL 429
Cdd:COG0148  398 VAKYNQLLRIEEELGDAARYAGRSAFKRL 426
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
1-429 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 911.32  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092   1 MTDIIDVFAREVLDSRGNPTIEVEVVTSGGVMGRAIVPSGASTGEYEAVELRDGDKERFLGKGVLQAVQNVNEIVAPELE 80
Cdd:COG0148    1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  81 GIDVTEQKLIDEMLIELDGTKNKGKLGANAILGVSLACAKAAAESCGLPLYKYIGGAYACTLPAPMMNILNGGEHADNNV 160
Cdd:COG0148   81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 161 DIQEFMIMPLGAESFREALRMGVEVFHTLKGVLKAKGMSTSVGDEGGFAPNLGSNEEAIEVILEAIDKAGYKAGSDIYIA 240
Cdd:COG0148  161 DIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIALA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 241 IDAASSEFYnkDKGVYVLEAEAEpEKTSAQMVEYYKYLVEKYPIISIEDGLDENDWDGWKLLTDAIGDKCQLVGDDLFVT 320
Cdd:COG0148  241 LDVAASEFY--KDGKYHLKGEGK-ELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVT 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 321 NTERLTRGIKTGVANSILVKLNQIGTLTETLDAIQTAREAGYTCVISHRSGESEDTTIADLAVAVNAGQIKTGSACRTDR 400
Cdd:COG0148  318 NPKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSER 397
                        410       420
                 ....*....|....*....|....*....
gi 502775092 401 IAKYNQLLRIEEELFDQAAYKGLGAFYNL 429
Cdd:COG0148  398 VAKYNQLLRIEEELGDAARYAGRSAFKRL 426
eno PRK00077
enolase; Provisional
1-430 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 876.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092   1 MTDIIDVFAREVLDSRGNPTIEVEVVTSGGVMGRAIVPSGASTGEYEAVELRDGDKERFLGKGVLQAVQNVNEIVAPELE 80
Cdd:PRK00077   1 MSKIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  81 GIDVTEQKLIDEMLIELDGTKNKGKLGANAILGVSLACAKAAAESCGLPLYKYIGGAYACTLPAPMMNILNGGEHADNNV 160
Cdd:PRK00077  81 GLDALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAKVLPVPMMNIINGGAHADNNV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 161 DIQEFMIMPLGAESFREALRMGVEVFHTLKGVLKAKGMSTSVGDEGGFAPNLGSNEEAIEVILEAIDKAGYKAGSDIYIA 240
Cdd:PRK00077 161 DIQEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGEDIALA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 241 IDAASSEFYnkDKGVYVLEAEaepEKTSAQMVEYYKYLVEKYPIISIEDGLDENDWDGWKLLTDAIGDKCQLVGDDLFVT 320
Cdd:PRK00077 241 LDCAASEFY--KDGKYVLEGE---GLTSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDLFVT 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 321 NTERLTRGIKTGVANSILVKLNQIGTLTETLDAIQTAREAGYTCVISHRSGESEDTTIADLAVAVNAGQIKTGSACRTDR 400
Cdd:PRK00077 316 NTKRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSRSER 395
                        410       420       430
                 ....*....|....*....|....*....|
gi 502775092 401 IAKYNQLLRIEEELFDQAAYKGLGAFYNLK 430
Cdd:PRK00077 396 IAKYNQLLRIEEELGDAARYAGKKAFKNLK 425
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
6-413 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 768.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092   6 DVFAREVLDSRGNPTIEVEVVTSGGVMGRAIVPSGASTGEYEAVELRDGDKERFLGKGVLQAVQNVNEIVAPELEGIDVT 85
Cdd:cd03313    1 KIKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDKSRYLGKGVLKAVKNVNEIIAPALIGMDVT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  86 EQKLIDEMLIELDGTKNKGKLGANAILGVSLACAKAAAESCGLPLYKYIGGAYACTLPAPMMNILNGGEHADNNVDIQEF 165
Cdd:cd03313   81 DQRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLAAYVLPVPMFNVINGGAHAGNKLDFQEF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 166 MIMPLGAESFREALRMGVEVFHTLKGVLKAKG--MSTSVGDEGGFAPNLGSNEEAIEVILEAIDKAGYKAGSDIYIAIDA 243
Cdd:cd03313  161 MIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGglLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKKIAIALDV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 244 ASSEFYNKDKGVYVLEAEAepEKTSAQMVEYYKYLVEKYPIISIEDGLDENDWDGWKLLTDAIGDKCQLVGDDLFVTNTE 323
Cdd:cd03313  241 AASEFYDEGKYVYDSDEGK--KLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFVTNPE 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 324 RLTRGIKTGVANSILVKLNQIGTLTETLDAIQTAREAGYTCVISHRSGESEDTTIADLAVAVNAGQIKTGSACRTDRIAK 403
Cdd:cd03313  319 RLKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSERTAK 398
                        410
                 ....*....|
gi 502775092 404 YNQLLRIEEE 413
Cdd:cd03313  399 YNQLLRIEEE 408
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
4-429 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 765.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092    4 IIDVFAREVLDSRGNPTIEVEVVTSGGVMGRAIVPSGASTGEYEAVELRDGDKERFLGKGVLQAVQNVNEIVAPELEGID 83
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKKRYLGKGVLKAVENVNEIIAPELIGMD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092   84 VTEQKLIDEMLIELDGTKNKGKLGANAILGVSLACAKAAAESCGLPLYKYIGGAYACTLPAPMMNILNGGEHADNNVDIQ 163
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNAYVLPVPMMNIINGGAHADNNLDFQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  164 EFMIMPLGAESFREALRMGVEVFHTLKGVLKAKGMSTSVGDEGGFAPNLGSNEEAIEVILEAIDKAGYKAGSDIYIAIDA 243
Cdd:TIGR01060 161 EFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGEDVALALDC 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  244 ASSEFYNKDKGVYVLEAEaEPEKTSAQMVEYYKYLVEKYPIISIEDGLDENDWDGWKLLTDAIGDKCQLVGDDLFVTNTE 323
Cdd:TIGR01060 241 AASEFYDEEDGKYVYKGE-NKQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFVTNTE 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  324 RLTRGIKTGVANSILVKLNQIGTLTETLDAIQTAREAGYTCVISHRSGESEDTTIADLAVAVNAGQIKTGSACRTDRIAK 403
Cdd:TIGR01060 320 ILREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSERIAK 399
                         410       420
                  ....*....|....*....|....*.
gi 502775092  404 YNQLLRIEEELFDQAAYKGLGAFYNL 429
Cdd:TIGR01060 400 YNQLLRIEEELGDSARYAGKNSFYRF 425
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
141-429 3.50e-159

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 450.78  E-value: 3.50e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  141 TLPAPMMNILNGGEHADNNVDIQEFMIMPLGAESFREALRMGVEVFHTLKGVLKAKG--MSTSVGDEGGFAPNLGSNEEA 218
Cdd:pfam00113   3 VLPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYgqSATNVGDEGGFAPNLQSNKEA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  219 IEVILEAIDKAGYKAgsDIYIAIDAASSEFYNKDKGVYVLEAEAEPEK-----TSAQMVEYYKYLVEKYPIISIEDGLDE 293
Cdd:pfam00113  83 LDLIVEAIEKAGYKG--KIKIAMDVASSEFYNKKDGKYDLDFKGEKSDkskklTSAQLADLYEELVKKYPIVSIEDPFDE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  294 NDWDGWKLLTDAIGDKCQLVGDDLFVTNTERLTRGIKTGVANSILVKLNQIGTLTETLDAIQTAREAGYTCVISHRSGES 373
Cdd:pfam00113 161 DDWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSGET 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 502775092  374 EDTTIADLAVAVNAGQIKTGSACRTDRIAKYNQLLRIEEELFDQAAYKGLGAFYNL 429
Cdd:pfam00113 241 EDTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEELGSEAKYAGRSFRKPL 296
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
1-429 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 911.32  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092   1 MTDIIDVFAREVLDSRGNPTIEVEVVTSGGVMGRAIVPSGASTGEYEAVELRDGDKERFLGKGVLQAVQNVNEIVAPELE 80
Cdd:COG0148    1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  81 GIDVTEQKLIDEMLIELDGTKNKGKLGANAILGVSLACAKAAAESCGLPLYKYIGGAYACTLPAPMMNILNGGEHADNNV 160
Cdd:COG0148   81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 161 DIQEFMIMPLGAESFREALRMGVEVFHTLKGVLKAKGMSTSVGDEGGFAPNLGSNEEAIEVILEAIDKAGYKAGSDIYIA 240
Cdd:COG0148  161 DIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIALA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 241 IDAASSEFYnkDKGVYVLEAEAEpEKTSAQMVEYYKYLVEKYPIISIEDGLDENDWDGWKLLTDAIGDKCQLVGDDLFVT 320
Cdd:COG0148  241 LDVAASEFY--KDGKYHLKGEGK-ELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVT 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 321 NTERLTRGIKTGVANSILVKLNQIGTLTETLDAIQTAREAGYTCVISHRSGESEDTTIADLAVAVNAGQIKTGSACRTDR 400
Cdd:COG0148  318 NPKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSER 397
                        410       420
                 ....*....|....*....|....*....
gi 502775092 401 IAKYNQLLRIEEELFDQAAYKGLGAFYNL 429
Cdd:COG0148  398 VAKYNQLLRIEEELGDAARYAGRSAFKRL 426
eno PRK00077
enolase; Provisional
1-430 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 876.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092   1 MTDIIDVFAREVLDSRGNPTIEVEVVTSGGVMGRAIVPSGASTGEYEAVELRDGDKERFLGKGVLQAVQNVNEIVAPELE 80
Cdd:PRK00077   1 MSKIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  81 GIDVTEQKLIDEMLIELDGTKNKGKLGANAILGVSLACAKAAAESCGLPLYKYIGGAYACTLPAPMMNILNGGEHADNNV 160
Cdd:PRK00077  81 GLDALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAKVLPVPMMNIINGGAHADNNV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 161 DIQEFMIMPLGAESFREALRMGVEVFHTLKGVLKAKGMSTSVGDEGGFAPNLGSNEEAIEVILEAIDKAGYKAGSDIYIA 240
Cdd:PRK00077 161 DIQEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGEDIALA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 241 IDAASSEFYnkDKGVYVLEAEaepEKTSAQMVEYYKYLVEKYPIISIEDGLDENDWDGWKLLTDAIGDKCQLVGDDLFVT 320
Cdd:PRK00077 241 LDCAASEFY--KDGKYVLEGE---GLTSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDLFVT 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 321 NTERLTRGIKTGVANSILVKLNQIGTLTETLDAIQTAREAGYTCVISHRSGESEDTTIADLAVAVNAGQIKTGSACRTDR 400
Cdd:PRK00077 316 NTKRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSRSER 395
                        410       420       430
                 ....*....|....*....|....*....|
gi 502775092 401 IAKYNQLLRIEEELFDQAAYKGLGAFYNLK 430
Cdd:PRK00077 396 IAKYNQLLRIEEELGDAARYAGKKAFKNLK 425
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
6-413 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 768.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092   6 DVFAREVLDSRGNPTIEVEVVTSGGVMGRAIVPSGASTGEYEAVELRDGDKERFLGKGVLQAVQNVNEIVAPELEGIDVT 85
Cdd:cd03313    1 KIKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDKSRYLGKGVLKAVKNVNEIIAPALIGMDVT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  86 EQKLIDEMLIELDGTKNKGKLGANAILGVSLACAKAAAESCGLPLYKYIGGAYACTLPAPMMNILNGGEHADNNVDIQEF 165
Cdd:cd03313   81 DQRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLAAYVLPVPMFNVINGGAHAGNKLDFQEF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 166 MIMPLGAESFREALRMGVEVFHTLKGVLKAKG--MSTSVGDEGGFAPNLGSNEEAIEVILEAIDKAGYKAGSDIYIAIDA 243
Cdd:cd03313  161 MIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGglLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKKIAIALDV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 244 ASSEFYNKDKGVYVLEAEAepEKTSAQMVEYYKYLVEKYPIISIEDGLDENDWDGWKLLTDAIGDKCQLVGDDLFVTNTE 323
Cdd:cd03313  241 AASEFYDEGKYVYDSDEGK--KLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFVTNPE 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 324 RLTRGIKTGVANSILVKLNQIGTLTETLDAIQTAREAGYTCVISHRSGESEDTTIADLAVAVNAGQIKTGSACRTDRIAK 403
Cdd:cd03313  319 RLKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSERTAK 398
                        410
                 ....*....|
gi 502775092 404 YNQLLRIEEE 413
Cdd:cd03313  399 YNQLLRIEEE 408
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
4-429 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 765.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092    4 IIDVFAREVLDSRGNPTIEVEVVTSGGVMGRAIVPSGASTGEYEAVELRDGDKERFLGKGVLQAVQNVNEIVAPELEGID 83
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKKRYLGKGVLKAVENVNEIIAPELIGMD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092   84 VTEQKLIDEMLIELDGTKNKGKLGANAILGVSLACAKAAAESCGLPLYKYIGGAYACTLPAPMMNILNGGEHADNNVDIQ 163
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNAYVLPVPMMNIINGGAHADNNLDFQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  164 EFMIMPLGAESFREALRMGVEVFHTLKGVLKAKGMSTSVGDEGGFAPNLGSNEEAIEVILEAIDKAGYKAGSDIYIAIDA 243
Cdd:TIGR01060 161 EFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGEDVALALDC 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  244 ASSEFYNKDKGVYVLEAEaEPEKTSAQMVEYYKYLVEKYPIISIEDGLDENDWDGWKLLTDAIGDKCQLVGDDLFVTNTE 323
Cdd:TIGR01060 241 AASEFYDEEDGKYVYKGE-NKQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFVTNTE 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  324 RLTRGIKTGVANSILVKLNQIGTLTETLDAIQTAREAGYTCVISHRSGESEDTTIADLAVAVNAGQIKTGSACRTDRIAK 403
Cdd:TIGR01060 320 ILREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSERIAK 399
                         410       420
                  ....*....|....*....|....*.
gi 502775092  404 YNQLLRIEEELFDQAAYKGLGAFYNL 429
Cdd:TIGR01060 400 YNQLLRIEEELGDSARYAGKNSFYRF 425
PTZ00081 PTZ00081
enolase; Provisional
1-424 0e+00

enolase; Provisional


Pssm-ID: 240259 [Multi-domain]  Cd Length: 439  Bit Score: 596.26  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092   1 MTDIIDVFAREVLDSRGNPTIEVEVVTSGGVMgRAIVPSGASTGEYEAVELRDGDKERFLGKGVLQAVQNVNEIVAPELE 80
Cdd:PTZ00081   1 MSTIKSIKAREILDSRGNPTVEVDLTTEKGVF-RAAVPSGASTGIYEALELRDGDKSRYLGKGVLKAVENVNEIIAPALI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  81 GIDVTEQKLIDEMLIE-LDGTKN-----KGKLGANAILGVSLACAKAAAESCGLPLYKYIGG-----AYACTLPAPMMNI 149
Cdd:PTZ00081  80 GKDVTDQKKLDKLMVEqLDGTKNewgwcKSKLGANAILAVSMAVARAAAAAKGVPLYKYLAQlagkpTDKFVLPVPCFNV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 150 LNGGEHADNNVDIQEFMIMPLGAESFREALRMGVEVFHTLKGVLKAK-GMS-TSVGDEGGFAPNLGSNEEAIEVILEAID 227
Cdd:PTZ00081 160 INGGKHAGNKLAFQEFMIAPVGAPSFKEALRMGAEVYHSLKSVIKKKyGLDaTNVGDEGGFAPNIKDPEEALDLLVEAIK 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 228 KAGYKAgsDIYIAIDAASSEFYNKDKGVYVLE-----AEAEPEKTSAQMVEYYKYLVEKYPIISIEDGLDENDWDGWKLL 302
Cdd:PTZ00081 240 KAGYEG--KVKICMDVAASEFYDKEKKVYDLDfknpnNDKSNKLTGEELVELYLDLVKKYPIVSIEDPFDQDDWEAYAKL 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 303 TDAIGDKCQLVGDDLFVTNTERLTRGIKTGVANSILVKLNQIGTLTETLDAIQTAREAGYTCVISHRSGESEDTTIADLA 382
Cdd:PTZ00081 318 TAAIGQKVQIVGDDLLVTNPTRIKKAIEKKACNALLLKVNQIGTVTEAIEAAKLAQKNGWGVMVSHRSGETEDTFIADLV 397
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 502775092 383 VAVNAGQIKTGSACRTDRIAKYNQLLRIEEELFDQAAYKGLG 424
Cdd:PTZ00081 398 VGLGTGQIKTGAPCRSERLAKYNQLLRIEEELGSNAVYAGEN 439
PLN00191 PLN00191
enolase
1-422 0e+00

enolase


Pssm-ID: 215095 [Multi-domain]  Cd Length: 457  Bit Score: 560.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092   1 MTDIIDVFAREVLDSRGNPTIEVEVVTSGGvMGRAIVPSGASTGEYEAVELRDGDKeRFLGKGVLQAVQNVNEIVAPELE 80
Cdd:PLN00191  25 MATITKVKARQIIDSRGNPTVEVDLHTSKG-MFRAAVPSGASTGIYEALELRDGDK-DYLGKGVLKAVKNVNEIIAPALI 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  81 GIDVTEQKLIDEMLIELDGTKNKGKLGANAILGVSLACAKAAAESCGLPLYKYI---GGAYACTLPAPMMNILNGGEHAD 157
Cdd:PLN00191 103 GMDPTDQTQIDNFMLELDGTPNKGKLGANAILAVSLAVCKAGAAEKGVPLYKHIadlAGNKKLVLPVPAFNVINGGSHAG 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 158 NNVDIQEFMIMPLGAESFREALRMGVEVFHTLKGVLKAK--GMSTSVGDEGGFAPNLGSNEEAIEVILEAIDKAGYKagS 235
Cdd:PLN00191 183 NKLAMQEFMILPVGASSFKEAMQMGSEVYHHLKAVIKKKygQDACNVGDEGGFAPNIQDNKEGLELLKEAIEKAGYT--G 260
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 236 DIYIAIDAASSEFYNKDKgVYVLEAEAEPE-----KTSAQMVEYYKYLVEKYPIISIEDGLDENDWDGWKLLTDaiGDKC 310
Cdd:PLN00191 261 KIKIGMDVAASEFYTKDK-KYDLDFKEENNdgsnkKSGDELIDLYKEFVSDYPIVSIEDPFDQDDWEHWAKLTS--LEDV 337
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 311 QLVGDDLFVTNTERLTRGIKTGVANSILVKLNQIGTLTETLDAIQTAREAGYTCVISHRSGESEDTTIADLAVAVNAGQI 390
Cdd:PLN00191 338 QIVGDDLLVTNPKRVAKAIQEKACNALLLKVNQIGTVTESIEAVKMSKAAGWGVMTSHRSGETEDSFIADLAVGLATGQI 417
                        410       420       430
                 ....*....|....*....|....*....|..
gi 502775092 391 KTGSACRTDRIAKYNQLLRIEEELFDQAAYKG 422
Cdd:PLN00191 418 KTGAPCRSERLAKYNQLLRIEEELGDEAVYAG 449
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
141-429 3.50e-159

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 450.78  E-value: 3.50e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  141 TLPAPMMNILNGGEHADNNVDIQEFMIMPLGAESFREALRMGVEVFHTLKGVLKAKG--MSTSVGDEGGFAPNLGSNEEA 218
Cdd:pfam00113   3 VLPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYgqSATNVGDEGGFAPNLQSNKEA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  219 IEVILEAIDKAGYKAgsDIYIAIDAASSEFYNKDKGVYVLEAEAEPEK-----TSAQMVEYYKYLVEKYPIISIEDGLDE 293
Cdd:pfam00113  83 LDLIVEAIEKAGYKG--KIKIAMDVASSEFYNKKDGKYDLDFKGEKSDkskklTSAQLADLYEELVKKYPIVSIEDPFDE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  294 NDWDGWKLLTDAIGDKCQLVGDDLFVTNTERLTRGIKTGVANSILVKLNQIGTLTETLDAIQTAREAGYTCVISHRSGES 373
Cdd:pfam00113 161 DDWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSGET 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 502775092  374 EDTTIADLAVAVNAGQIKTGSACRTDRIAKYNQLLRIEEELFDQAAYKGLGAFYNL 429
Cdd:pfam00113 241 EDTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEELGSEAKYAGRSFRKPL 296
Enolase_N pfam03952
Enolase, N-terminal domain;
4-134 5.88e-89

Enolase, N-terminal domain;


Pssm-ID: 461105 [Multi-domain]  Cd Length: 131  Bit Score: 265.78  E-value: 5.88e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092    4 IIDVFAREVLDSRGNPTIEVEVVTSGGVMGRAIVPSGASTGEYEAVELRDGDKERFLGKGVLQAVQNVNEIVAPELEGID 83
Cdd:pfam03952   1 ITKVKAREILDSRGNPTVEVEVTLEDGTFGRAAVPSGASTGEHEAVELRDGDKSRYGGKGVLKAVENVNEIIAPALIGMD 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 502775092   84 VTEQKLIDEMLIELDGTKNKGKLGANAILGVSLACAKAAAESCGLPLYKYI 134
Cdd:pfam03952  81 ATDQRAIDRALIELDGTENKSKLGANAILGVSLAVAKAAAAALGLPLYRYL 131
PRK08350 PRK08350
hypothetical protein; Provisional
1-414 9.27e-26

hypothetical protein; Provisional


Pssm-ID: 169397 [Multi-domain]  Cd Length: 341  Bit Score: 107.20  E-value: 9.27e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092   1 MTDIIDVFAREVLDSRGNPTIEVEVVTSGGvMGRAIVPSGASTGEYEAVELRdgdkerflgkgvlqAVQNVNEIVAPELE 80
Cdd:PRK08350   1 MTVIENIIGRVAVLRGGKYSVEVDVITDSG-FGRFAAPIDENPSLYIAEAHR--------------AVSEVDEIIGPELI 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  81 GIDVTEQKLIDEMLIELDGTKNKGKLGANAILGVSLACAKAAAESCGLPLYKYIGGAYACTLPAPMMNILNgGEHADNNV 160
Cdd:PRK08350  66 GFDASEQELIDSYLWEIDGTEDFSHIGANTALAVSVAVAKAAANSKNMPLYSYIGGTFTTELPVPILEFAE-DENFEYYV 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 161 DIQEFMimplgaesfrealrmgvEVFHTLKGVLKAKGMstsvgdeggfapnlgSNEEAIEVILEAIDKAGYKAGSDIYIA 240
Cdd:PRK08350 145 LVRDLM-----------------EITDVVDAVNKILEN---------------SKEVSLEGLSKASEKAGDELGLEVALG 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 241 IdaassefynkdkgvyVLEAEAEPEKTSAqmveyykyLVEKYPIISIEDGLDEndwdgwKLLTDAIGDKCQLV--GDDLF 318
Cdd:PRK08350 193 I---------------AQKREMETEKVLN--------LVEDNNIAYIKPIGDE------ELFLELIAGTHGVFidGEYLF 243
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 319 VTNTERLTRgiktgVANSILVKLNQIGTLTETLDAIQTAREAGYTCVISHRSGESEDTTIADLAVAVNAGQIktgsACRT 398
Cdd:PRK08350 244 RTRNILDRR-----YYNALSIKPINLGTLTDLYNLVNDVKSERITPILAEAKYESADEALPHLAVGLRCPAM----LIHK 314
                        410
                 ....*....|....*.
gi 502775092 399 DRIAKYNQLLRIEEEL 414
Cdd:PRK08350 315 DSVEKINELNRIAEDL 330
enolase_like cd00308
Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is ...
110-392 1.28e-16

Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Enolase superfamily contains different enzymes, like enolases, glutarate-, fucanate- and galactonate dehydratases, o-succinylbenzoate synthase, N-acylamino acid racemase, L-alanine-DL-glutamate epimerase, mandelate racemase, muconate lactonizing enzyme and 3-methylaspartase.


Pssm-ID: 238188 [Multi-domain]  Cd Length: 229  Bit Score: 78.52  E-value: 1.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 110 AILGVSLACAKAAAESCGLPLYKYIGGAYactlpapmmnilnggehadnnvdiqefmimplgaesfrealRMGVEVFHTL 189
Cdd:cd00308   43 VISGIDMALWDLAAKALGVPLAELLGGGS-----------------------------------------RDRVPAYGSI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 190 kgvlkakgmstsvgdeggfapnlgsneEAIEVILEAIdkagykaGSDIYIAIDAASSEFYNkdkgvyvleaeaepektsa 269
Cdd:cd00308   82 ---------------------------ERVRAVREAF-------GPDARLAVDANGAWTPK------------------- 108
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 270 QMVEYYKYLvEKYPIISIEDGLDENDWDGWKLLTDAIGdkCQLVGDDLFVTNTERLtRGIKTGVANSILVKLNQIGTLTE 349
Cdd:cd00308  109 EAIRLIRAL-EKYGLAWIEEPCAPDDLEGYAALRRRTG--IPIAADESVTTVDDAL-EALELGAVDILQIKPTRVGGLTE 184
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 502775092 350 TLDAIQTAREAGYTCVISHRSGESEDTT-IADLAVAV-NAGQIKT 392
Cdd:cd00308  185 SRRAADLAEAFGIRVMVHGTLESSIGTAaALHLAAALpNDRAIET 229
PTZ00378 PTZ00378
hypothetical protein; Provisional
50-414 3.36e-08

hypothetical protein; Provisional


Pssm-ID: 173571 [Multi-domain]  Cd Length: 518  Bit Score: 55.65  E-value: 3.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  50 ELRDGDKERFL--GKGVLQAVQNVneiVAPELEGIDVTEQKLIDEMLIELDGTKNKGKLGANAILGVSLACAKAAAESCG 127
Cdd:PTZ00378  91 GERDGEADATLdpAEYTTEALQNS---YFPRLLQLGARDQREFDSTLRAALSTSPLANVGSAVQWALSIVASLAAARCRS 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 128 LPLYKYIG---GAYACTLPAPMMNIL-------NGGEHADNNVDIQEFMIMPLGAESfREALRMGVEVFHTLkgvlkAKG 197
Cdd:PTZ00378 168 VPLFQYLRalfGSLTSVETFSMPQLCitffgpgNPSTARLALKSVLFSPVMPSGTVL-RERMQKIFAAFHHF-----CQS 241
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 198 MSTSVGDEGGFAPNLGSN-EEAIEVILEAIDKAGYKAGSDIYIAIDAASS-----EFYNKDKGVY--------VLEA--E 261
Cdd:PTZ00378 242 HNSSVRSDGSLHWDGFANlTDAVKLATEALRAVQLTPGTDVCLGLRMAASttrvpATAVADGGAWkeakddceVLYSlfP 321
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 262 AEPEKTSAQMVEYYKYLVEKYP--IISIEDGLDENDWDGWKLLTDAIGDKCQLVGDDLFV-TNTERLTRGIKTGVANSIL 338
Cdd:PTZ00378 322 GEPDVTGDQLSEYVREQLQAVPdiVVYVEDTHCDEDTFGLQRLQAALGDSIVLSGVDVYArSEYKKVESGLRGLWTSNIV 401
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 502775092 339 VKLNQIGTLTETLDAIQTAREAGYTCV-ISHRSGESEDTTIADLAVAVNAGQIKTGSACRTDRIAKYNQLLRIEEEL 414
Cdd:PTZ00378 402 LNPCAIGTLSDVVEIVRAVGEDEGRAVtVLVQTLAGNAATAAHLAVAMGARFLCSGGLFSAHQCEVVSQLASRQDEL 478
RspA COG4948
L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane ...
23-366 3.42e-07

L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane/envelope biogenesis, General function prediction only]; L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 443975 [Multi-domain]  Cd Length: 359  Bit Score: 51.75  E-value: 3.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  23 VEVVTSGGVMGRAivpsgastgeyEAVelrdgdkerFLGKGVLQAVQNVNEIVAPELEGIDVTEqklIDEMLIELDgtkN 102
Cdd:COG4948   34 VRVETDDGITGWG-----------EAV---------PGGTGAEAVAAALEEALAPLLIGRDPLD---IEALWQRLY---R 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 103 KGKLGANAILGVSLAC----AKAAaescGLPLYKYIGGAYACTLPapmmnilnggehADNNVDIQEFMIMplgAESFREA 178
Cdd:COG4948   88 ALPGNPAAKAAVDMALwdllGKAL----GVPVYQLLGGKVRDRVP------------VYATLGIDTPEEM---AEEAREA 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 179 LRMGvevFHTLKgvLKAkgmstsvgdeGGFAPnlgsnEEAIEVIlEAIDKAgykAGSDIYIAIDAassefyNkdkGVYvl 258
Cdd:COG4948  149 VARG---FRALK--LKV----------GGPDP-----EEDVERV-RAVREA---VGPDARLRVDA------N---GAW-- 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 259 eaeaepekTSAQMVEYYKYLvEKYPIISIEDGLDENDWDGWKLLTDAIGdkCQLVGDDLfVTNTERLTRGIKTGVANSIL 338
Cdd:COG4948  194 --------TLEEAIRLLRAL-EDLGLEWIEQPLPAEDLEGLAELRRATP--VPIAADES-LTSRADFRRLIEAGAVDIVN 261
                        330       340
                 ....*....|....*....|....*...
gi 502775092 339 VKLNQIGTLTETLDAIQTAREAGYTCVI 366
Cdd:COG4948  262 IKLSKVGGLTEALRIAALAEAHGVPVMP 289
MLE_like cd03315
Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this ...
113-367 9.13e-05

Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can function as general acid/base catalysts, a Lys-X-Lys motif and another conserved lysine. Despite these conserved residues, the members of the MLE subgroup, like muconate lactonizing enzyme, o-succinylbenzoate synthase (OSBS) and N-acylamino acid racemase (NAAAR), catalyze different reactions.


Pssm-ID: 239431 [Multi-domain]  Cd Length: 265  Bit Score: 43.87  E-value: 9.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 113 GVSLACAKAAAESCGLPLYKyIGGAYACTLPAPMMniLNGGEHADNnvdiqefmimplgAESFREALRMGVEVFhtlkgv 192
Cdd:cd03315   47 AVDMALWDLWGKRLGVPVYL-LLGGYRDRVRVAHM--LGLGEPAEV-------------AEEARRALEAGFRTF------ 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 193 lKAKgmstsVGdeggfaPNLGSNEEAIEVILEAIdkagykaGSDIYIAIDAASSefYNKDKGVYVLEAeaepektsaqmv 272
Cdd:cd03315  105 -KLK-----VG------RDPARDVAVVAALREAV-------GDDAELRVDANRG--WTPKQAIRALRA------------ 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 273 eyykylVEKYPIISIEDGLDENDWDGWKLLTDAIGdkCQLVGDDLfVTNTERLTRGIKTGVANSILVKLNQIGTLTETLD 352
Cdd:cd03315  152 ------LEDLGLDYVEQPLPADDLEGRAALARATD--TPIMADES-AFTPHDAFRELALGAADAVNIKTAKTGGLTKAQR 222
                        250
                 ....*....|....*
gi 502775092 353 AIQTAREAGYTCVIS 367
Cdd:cd03315  223 VLAVAEALGLPVMVG 237
MR_like cd03316
Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup ...
23-307 9.24e-04

Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. Members of the MR subgroup are mandelate racemase, D-glucarate/L-idarate dehydratase (GlucD), D-altronate/D-mannonate dehydratase , D-galactonate dehydratase (GalD) , D-gluconate dehydratase (GlcD), and L-rhamnonate dehydratase (RhamD).


Pssm-ID: 239432 [Multi-domain]  Cd Length: 357  Bit Score: 41.06  E-value: 9.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092  23 VEVVTSGGVMGRAIVPSGASTGEYEAVelrdgdkerflgkgvlqavqnVNEIVAPELEGIDVTE-QKLIDEMLielDGTK 101
Cdd:cd03316   29 VRVTTDDGITGWGEAYPGGRPSAVAAA---------------------IEDLLAPLLIGRDPLDiERLWEKLY---RRLF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 102 NKGKLG--ANAILGVSLAC----AKAAaescGLPLYKYIGG-------AYActlpapmmnilNGGEHADnnvDIQEFmim 168
Cdd:cd03316   85 WRGRGGvaMAAISAVDIALwdikGKAA----GVPVYKLLGGkvrdrvrVYA-----------SGGGYDD---SPEEL--- 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502775092 169 plgAESFREALRMGvevFHTLKgvLKakgmstsVGDEGGFAPNLGSNEEAIEVILEAIdkagykaGSDIYIAIDAASSef 248
Cdd:cd03316  144 ---AEEAKRAVAEG---FTAVK--LK-------VGGPDSGGEDLREDLARVRAVREAV-------GPDVDLMVDANGR-- 199
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 502775092 249 YNKDKGVYVLEAeaepektsaqmveyykylVEKYPIISIEDGLDENDWDGWKLLTDAIG 307
Cdd:cd03316  200 WDLAEAIRLARA------------------LEEYDLFWFEEPVPPDDLEGLARLRQATS 240
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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