|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11462 |
PRK11462 |
putative transporter; Provisional |
1-464 |
0e+00 |
|
putative transporter; Provisional
Pssm-ID: 183145 Cd Length: 460 Bit Score: 871.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 1 MKDHILSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLLARALDAISDPCMGLLADRTRSRWGKFR 80
Cdd:PRK11462 1 MKSEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 81 PWILFGAIPFGLVCVLAYSSPDLSHNGKLIYAAVTYTLLTLLYTVVNIPYCALGGVITDNPTQRISLQSWRFVLATAGGM 160
Cdd:PRK11462 81 PWVLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 161 LSTVLMMPLVNFIGGEDKALGFQGGIAVLSVVAFLMLAFCFFTTKERVEAPPSSTSMREDLRDIWRNDQWRVVGVLTILN 240
Cdd:PRK11462 161 LSTVLMMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPTTTSMREDLRDIWQNDQWRIVGLLTIFN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 241 ILAVCVRGGAMMYYTTWIMGSAALFTVFLTTYCVGNLIGSALAKPLTDWKCKVSVFWWTNALLAVLSVAMFFVPMDAEIT 320
Cdd:PRK11462 241 ILAVCVRGGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASIT 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 321 MFTFIFIIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLALGGALIGWMLAGGGYDAAAKTQNSA 400
Cdd:PRK11462 321 MFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNSA 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502732056 401 TLTIIIALFTLVPAVCYLLSAVIAKRYYTLKTPFLKKMMAELAEGARRNEQDFTaapiDKEWQN 464
Cdd:PRK11462 401 TISIIIALFTIVPAICYLLSAIIAKRYYSLTTHNLKTVMEQLAQGKRRCQQQFT----SQEVQN 460
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
11-442 |
3.66e-163 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 467.50 E-value: 3.66e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 11 KIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLLARALDAISDPCMGLLADRTRSRWGKFRPWILFGAIPF 90
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGAIPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 91 GLVCVLAYSSPDLSHNGKLIYAAVTYTLLTLLYTVVNIPYCALGGVITDNPTQRISLQSWRFVLATAGGMLSTVLMMPLV 170
Cdd:TIGR00792 81 SIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 171 NFIGGEDKALGFQGGIAVLSVVAFLMLAFCFFTTKERVEAPP----SSTSMREDLRDIWRNDQWRVVGVLTILNILAVCV 246
Cdd:TIGR00792 161 SYFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSEIPknieKKLSLKQIFKALFKNDQLLILCLAYLFYNLAFNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 247 RGGAMMYYTTWIMGSAALFTVFLTTYCVGNLIGsALAKPLTDWKCKVSVFWWTNALLAVLSVAMFFVPMDAEITMFTFIF 326
Cdd:TIGR00792 241 KNGVQVYYFTYVLGDPELFSYMGSIAIVAGLIG-VLLFPRLVKKFGRKILFAGGILLMVLGYLIFFFAGSNLPLILVLII 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 327 IIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLALGGALIGWMLAGGGYDAAAkTQNSATLTIII 406
Cdd:TIGR00792 320 LAGFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGIIGYVANA-AQSPITLNGIK 398
|
410 420 430
....*....|....*....|....*....|....*.
gi 502732056 407 ALFTLVPAVCYLLSAVIAKRYYTLKTPFLKKMMAEL 442
Cdd:TIGR00792 399 ILMFAVPALFLLLAAIIIGRFYKLTEKKHAEIVEEL 434
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
11-431 |
2.77e-131 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 385.80 E-value: 2.77e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 11 KIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLLARALDAISDPCMGLLADRTRSRWGKFRPWILFGAIPF 90
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 91 GLVCVLAYSSPDLSHNGKLIYAAVTYTLLTLLYTVVNIPYCALGGVITDNPTQRISLQSWRFVLATAGGMLSTVLMMPLV 170
Cdd:cd17332 81 ALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 171 NFIGGEDKALGFQGGIAVLSVVAFLMLAFCFFTTKERVEAPPSSTS---MREDLRDIWRNDQWRVVGVLTILNILAVCVR 247
Cdd:cd17332 161 AYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSklpLLKSLKALLKNRPFLILLLAYLLYFLAFNIV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 248 GGAMMYYTTWIMGSAALFTVFLTTYCVGNLIGSALAKPLTDWKCKVSVFWWTNALLAVLSVAMFFVPMDAEITMFTFIFI 327
Cdd:cd17332 241 NTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 328 IGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLALGGALIGWMLAGGGYDAAAKTQNSATLTIIIA 407
Cdd:cd17332 321 AGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAAAQSASALNGIRL 400
|
410 420
....*....|....*....|....
gi 502732056 408 LFTLVPAVCYLLSAVIAKRYYTLK 431
Cdd:cd17332 401 LIAVLPAVLLLLALILMSFYPLDK 424
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
6-444 |
1.44e-120 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 359.60 E-value: 1.44e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 6 LSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLLARALDAISDPCMGLLADRTRSRWGKFRPWILF 85
Cdd:COG2211 7 LSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 86 GAIPFGLVCVLAYSSPDLSHNGKLIYAAVTYTLLTLLYTVVNIPYCALGGVITDNPTQRISLQSWRFVLATAGGMLSTVL 165
Cdd:COG2211 87 GAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 166 MMPLVNFIGGeDKALGFQGGIAVLSVVAFLMLAFCFFTTKERVEAPPSSTSMREDLRDIWRNDQWRVVGVLTILNILAVC 245
Cdd:COG2211 167 PPPLVAAFGG-DAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 246 VRGGAMMYYTTWIMG-SAALFTVFLTTYCVGNLIGSALAKPLTDWKCKVSVFWWTNALLAVLSVAMFFVPMDAEITMFTF 324
Cdd:COG2211 246 LVAALLLYYFKYVLGlSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 325 IFIIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLALGGALIGWMLAGGGYDAAAkTQNSATLTI 404
Cdd:COG2211 326 AALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGA-AQSPSALTG 404
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 502732056 405 IIALFTLVPAVCYLLSAVIAKRyYTLKTPFLKKMMAELAE 444
Cdd:COG2211 405 IRLLFFLLPAVLLLLAALLLLF-YPLTRERHAEIRAELAA 443
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
13-427 |
3.68e-78 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 249.53 E-value: 3.68e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 13 GYGMGDAAsHIIFDNVM-LYMMFFYTDIFGIPAGFVGTMFLLARALDAISDPCMGLLADRTRSRWGKFRPWILFGAIPFG 91
Cdd:pfam13347 1 GYGSGALA-AGIKYAGLaTYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 92 LVCVLAYSSPDLSHNGKLIYAAVTYTLLTLLYTVVNIPYCALGGVITDNPTQRISLQSWRFVLATAGGMLSTVLMMPLVN 171
Cdd:pfam13347 80 VSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 172 FIGG-EDKALGFQGGIAVLSVVAFLMLAFCFFTTKERVEAPP-------SSTSMREDLRDIWRNDQWRVVGVLTILNILA 243
Cdd:pfam13347 160 ILGGtGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSkedtgqkEAGSLLDMLKEVFRNRAFLILLASFLLAALA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 244 VCVRGGAMMYYTTWIMGSAALFTVFLTTYCVGNLIGSALAKPLTDWKCKVSVFWWTNALLAVLSVAMFFVPMDAEITMFT 323
Cdd:pfam13347 240 MGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 324 FIFIIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLALGGALIGWMLAGGGYDAAAKTQNSATLT 403
Cdd:pfam13347 320 LYIIIGFGYGSSFFLPWSMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLLSAFGYNAGDSVQSPQAVT 399
|
410 420
....*....|....*....|....
gi 502732056 404 IIIALFTLVPAVCYLLSAVIAKRY 427
Cdd:pfam13347 400 AIRLLYAVLPAVLFLVALLLLYFY 423
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11462 |
PRK11462 |
putative transporter; Provisional |
1-464 |
0e+00 |
|
putative transporter; Provisional
Pssm-ID: 183145 Cd Length: 460 Bit Score: 871.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 1 MKDHILSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLLARALDAISDPCMGLLADRTRSRWGKFR 80
Cdd:PRK11462 1 MKSEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 81 PWILFGAIPFGLVCVLAYSSPDLSHNGKLIYAAVTYTLLTLLYTVVNIPYCALGGVITDNPTQRISLQSWRFVLATAGGM 160
Cdd:PRK11462 81 PWVLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 161 LSTVLMMPLVNFIGGEDKALGFQGGIAVLSVVAFLMLAFCFFTTKERVEAPPSSTSMREDLRDIWRNDQWRVVGVLTILN 240
Cdd:PRK11462 161 LSTVLMMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPTTTSMREDLRDIWQNDQWRIVGLLTIFN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 241 ILAVCVRGGAMMYYTTWIMGSAALFTVFLTTYCVGNLIGSALAKPLTDWKCKVSVFWWTNALLAVLSVAMFFVPMDAEIT 320
Cdd:PRK11462 241 ILAVCVRGGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASIT 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 321 MFTFIFIIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLALGGALIGWMLAGGGYDAAAKTQNSA 400
Cdd:PRK11462 321 MFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNSA 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 502732056 401 TLTIIIALFTLVPAVCYLLSAVIAKRYYTLKTPFLKKMMAELAEGARRNEQDFTaapiDKEWQN 464
Cdd:PRK11462 401 TISIIIALFTIVPAICYLLSAIIAKRYYSLTTHNLKTVMEQLAQGKRRCQQQFT----SQEVQN 460
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
11-442 |
3.66e-163 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 467.50 E-value: 3.66e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 11 KIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLLARALDAISDPCMGLLADRTRSRWGKFRPWILFGAIPF 90
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGAIPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 91 GLVCVLAYSSPDLSHNGKLIYAAVTYTLLTLLYTVVNIPYCALGGVITDNPTQRISLQSWRFVLATAGGMLSTVLMMPLV 170
Cdd:TIGR00792 81 SIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 171 NFIGGEDKALGFQGGIAVLSVVAFLMLAFCFFTTKERVEAPP----SSTSMREDLRDIWRNDQWRVVGVLTILNILAVCV 246
Cdd:TIGR00792 161 SYFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSEIPknieKKLSLKQIFKALFKNDQLLILCLAYLFYNLAFNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 247 RGGAMMYYTTWIMGSAALFTVFLTTYCVGNLIGsALAKPLTDWKCKVSVFWWTNALLAVLSVAMFFVPMDAEITMFTFIF 326
Cdd:TIGR00792 241 KNGVQVYYFTYVLGDPELFSYMGSIAIVAGLIG-VLLFPRLVKKFGRKILFAGGILLMVLGYLIFFFAGSNLPLILVLII 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 327 IIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLALGGALIGWMLAGGGYDAAAkTQNSATLTIII 406
Cdd:TIGR00792 320 LAGFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGIIGYVANA-AQSPITLNGIK 398
|
410 420 430
....*....|....*....|....*....|....*.
gi 502732056 407 ALFTLVPAVCYLLSAVIAKRYYTLKTPFLKKMMAEL 442
Cdd:TIGR00792 399 ILMFAVPALFLLLAAIIIGRFYKLTEKKHAEIVEEL 434
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
1-443 |
1.16e-139 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 407.96 E-value: 1.16e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 1 MKDHILSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLLARALDAISDPCMGLLADRTRSRWGKFR 80
Cdd:PRK09669 1 MNTSQLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQFR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 81 PWILFGAIPFGLVCVLAYSSPDLSHNGKLIYAAVTYTLLTLLYTVVNIPYCALGGVITDNPTQRISLQSWRFVLATAGGM 160
Cdd:PRK09669 81 PYLLWFAIPFGVVCLLTFYTPDFGATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 161 LSTVLMMPLVNFIGGEDKALGFQGGIAVLSVVAFLMLAFCFFTTKERVEAPP-SSTSMREDLRDIWRNDQWRVVGVLTIL 239
Cdd:PRK09669 161 IVSVIALPLVDILGKGDEQKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVdNSSSVWKDLKLLLGNSQWRIMFIFNVV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 240 NILAVCVRGGAMMYYTTWIMGSAALFTVFLTTYCVGNLIGSALAKPLTDWKCKVSVFWWTNALLAVLSVAMFFVPMDAEI 319
Cdd:PRK09669 241 LLTAVVTRGGATLYYVNYVLLRPDLATLFLVTGMIAGLFGALLSERLLGKFDRVRAFKWTIVAFVILSALIFFIPPSNVW 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 320 TMFTFIFIIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLALGGALIGWMLAGGGYDAAAKTQNS 399
Cdd:PRK09669 321 LIFALNILFNFIQNLTTPLQWSMFSDVVDYEEKRSGRRLDGLVFSTNLFAIKLGLAIGGAVVGWILAWVDYVGGAAVQSA 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 502732056 400 ATLTIIIALFTLVPAVCYLLSAVIAKRyYTLKTPFLKKMMAELA 443
Cdd:PRK09669 401 SVLTTINLLFTVIPGVLFAGMAIILNF-YKLNDARVEAIAQELV 443
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
11-431 |
2.77e-131 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 385.80 E-value: 2.77e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 11 KIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLLARALDAISDPCMGLLADRTRSRWGKFRPWILFGAIPF 90
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 91 GLVCVLAYSSPDLSHNGKLIYAAVTYTLLTLLYTVVNIPYCALGGVITDNPTQRISLQSWRFVLATAGGMLSTVLMMPLV 170
Cdd:cd17332 81 ALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 171 NFIGGEDKALGFQGGIAVLSVVAFLMLAFCFFTTKERVEAPPSSTS---MREDLRDIWRNDQWRVVGVLTILNILAVCVR 247
Cdd:cd17332 161 AYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSklpLLKSLKALLKNRPFLILLLAYLLYFLAFNIV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 248 GGAMMYYTTWIMGSAALFTVFLTTYCVGNLIGSALAKPLTDWKCKVSVFWWTNALLAVLSVAMFFVPMDAEITMFTFIFI 327
Cdd:cd17332 241 NTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 328 IGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLALGGALIGWMLAGGGYDAAAKTQNSATLTIIIA 407
Cdd:cd17332 321 AGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAAAQSASALNGIRL 400
|
410 420
....*....|....*....|....
gi 502732056 408 LFTLVPAVCYLLSAVIAKRYYTLK 431
Cdd:cd17332 401 LIAVLPAVLLLLALILMSFYPLDK 424
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
6-444 |
1.44e-120 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 359.60 E-value: 1.44e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 6 LSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLLARALDAISDPCMGLLADRTRSRWGKFRPWILF 85
Cdd:COG2211 7 LSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 86 GAIPFGLVCVLAYSSPDLSHNGKLIYAAVTYTLLTLLYTVVNIPYCALGGVITDNPTQRISLQSWRFVLATAGGMLSTVL 165
Cdd:COG2211 87 GAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 166 MMPLVNFIGGeDKALGFQGGIAVLSVVAFLMLAFCFFTTKERVEAPPSSTSMREDLRDIWRNDQWRVVGVLTILNILAVC 245
Cdd:COG2211 167 PPPLVAAFGG-DAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 246 VRGGAMMYYTTWIMG-SAALFTVFLTTYCVGNLIGSALAKPLTDWKCKVSVFWWTNALLAVLSVAMFFVPMDAEITMFTF 324
Cdd:COG2211 246 LVAALLLYYFKYVLGlSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 325 IFIIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLALGGALIGWMLAGGGYDAAAkTQNSATLTI 404
Cdd:COG2211 326 AALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGA-AQSPSALTG 404
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 502732056 405 IIALFTLVPAVCYLLSAVIAKRyYTLKTPFLKKMMAELAE 444
Cdd:COG2211 405 IRLLFFLLPAVLLLLAALLLLF-YPLTRERHAEIRAELAA 443
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
13-427 |
3.68e-78 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 249.53 E-value: 3.68e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 13 GYGMGDAAsHIIFDNVM-LYMMFFYTDIFGIPAGFVGTMFLLARALDAISDPCMGLLADRTRSRWGKFRPWILFGAIPFG 91
Cdd:pfam13347 1 GYGSGALA-AGIKYAGLaTYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 92 LVCVLAYSSPDLSHNGKLIYAAVTYTLLTLLYTVVNIPYCALGGVITDNPTQRISLQSWRFVLATAGGMLSTVLMMPLVN 171
Cdd:pfam13347 80 VSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 172 FIGG-EDKALGFQGGIAVLSVVAFLMLAFCFFTTKERVEAPP-------SSTSMREDLRDIWRNDQWRVVGVLTILNILA 243
Cdd:pfam13347 160 ILGGtGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSkedtgqkEAGSLLDMLKEVFRNRAFLILLASFLLAALA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 244 VCVRGGAMMYYTTWIMGSAALFTVFLTTYCVGNLIGSALAKPLTDWKCKVSVFWWTNALLAVLSVAMFFVPMDAEITMFT 323
Cdd:pfam13347 240 MGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 324 FIFIIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLALGGALIGWMLAGGGYDAAAKTQNSATLT 403
Cdd:pfam13347 320 LYIIIGFGYGSSFFLPWSMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLLSAFGYNAGDSVQSPQAVT 399
|
410 420
....*....|....*....|....
gi 502732056 404 IIIALFTLVPAVCYLLSAVIAKRY 427
Cdd:pfam13347 400 AIRLLYAVLPAVLFLVALLLLYFY 423
|
|
| PRK09848 |
PRK09848 |
glucuronide transporter; Provisional |
6-442 |
9.65e-68 |
|
glucuronide transporter; Provisional
Pssm-ID: 182109 [Multi-domain] Cd Length: 448 Bit Score: 223.12 E-value: 9.65e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 6 LSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLLARALDAISDPCMGLLADRTRSRWGKFRPWILF 85
Cdd:PRK09848 5 LSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVNTRWGKFRPFLLF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 86 GAIPFGLVCVLAYSSP-DLSHNGKLIYAAVTYTLLTLLYTVVNIPYCALGGVITDNPTQRISLQSWRFVLATAGGMLSTV 164
Cdd:PRK09848 85 GTAPLMIFSVLVFWVPtDWSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASLTFVCLAF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 165 LMMPLVNFIGGEDKALGFQGGIAVLSVVAFLMLAFCFFTTKERVEAPPSSTSMREDLRDIWRNDQwrvvgvLTILNILAV 244
Cdd:PRK09848 165 LIGPSIKNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENVVRIVAQPSLKISLQTLKRNRP------LFMLCIGAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 245 CVRGGAM------MYYTTWIMGSAALFTVF-LTTYCVGNLIGSALAKPLTDWKCKVSVFWWTNALLAVLSVAMFFVPMDA 317
Cdd:PRK09848 239 CVLISTFavsassLFYVRYVLNDTGLFTVLvLVQNLVGTVASAPLVPGMVARIGKKNTFLIGALLGTCGYLLFFWVSVWS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 318 EITMFTFIFIIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLALGGALIGWMLAGGGYDAAAKTQ 397
Cdd:PRK09848 319 LPVALVALAIASIGQGVTMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQVQT 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 502732056 398 NSATLTIIIALfTLVPAVCYLLSAVIAKRYytlktPFLKKMMAEL 442
Cdd:PRK09848 399 PEVIMGIRTSI-ALVPCGFMLLAFVIIWFY-----PLTDKKFKEI 437
|
|
| PRK10429 |
PRK10429 |
melibiose:sodium transporter MelB; |
6-448 |
9.53e-67 |
|
melibiose:sodium transporter MelB;
Pssm-ID: 182453 Cd Length: 473 Bit Score: 221.51 E-value: 9.53e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 6 LSVKEKIGYGMG----DAASHIIFdnvmLYMMFFYTDIFGIPAGFVGTMFLLARALDAISDPCMGLLADRTRSRWGKFRP 81
Cdd:PRK10429 3 ISMTTKLSYGFGafgkDFAIGIVY----MYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNNTRSRWGKFKP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 82 WILFGAIPFGLVCVLAYSSPDLSHNGKLIYAAVTYTLLTLLYTVVNIPYCALGGVITDNPTQRISLQSWRFVLATAGGML 161
Cdd:PRK10429 79 WILIGTLANSVVLFLLFSAHLFEGTAQYVFVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYPRFFASLAGFV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 162 STVLMMPLVNFIGGEDKALGFQGGIAVLSVVaFLMLAFCF-------FTTKERVEAPPSSTSMREDLRDIWRNDQWRV-V 233
Cdd:PRK10429 159 TAGFTLPFVNYVGGGDRGFGFQMFTLVLIAF-FIVSTIITlrnvhevYSSDNQVSAEGSHLTLKDIVALIYKNDQLSClL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 234 GVLTILNILAVCVrGGAMMYYTTWIMGSAALFTVFLTTYCVGNLIGSALAKPLTDWKCKvSVFWWTNALLAVLSVAMFFV 313
Cdd:PRK10429 238 GMALAYNIASNII-NGFAIYYFTYVIGDADLFPYYLSYAGAANLVTLILFPRLVKSLSR-RILWAGASIFPVLSCGVLLL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 314 PMDAEITMFTFIFIIGVLHQLVTPIQW----VMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLALGGALIGWMLAGGG 389
Cdd:PRK10429 316 MGLAAPHNALLIVIAGILLNIGTALFWvlqvIMVADTVDYGEYKLGIRCESIAYSVQTMVVKGGSAFAAFFIGVVLGLIG 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 502732056 390 YDAAAkTQNSATLTIIIALFTLVPAVCYLLSAVIAKRYYTLKTPFLKKMMAELAEGARR 448
Cdd:PRK10429 396 YVPNV-EQSAQTLLGMQFIMIGLPTLFFMITLVLYFRYYRLNGDFLRRIQIHLLDKYRK 453
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
36-389 |
1.28e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 62.83 E-value: 1.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 36 YTDIFGIPAGFVGTMFLLARALDAISDPCMGLLADRTRsrwgkFRPWILFGAIPFGLVCVLAYSSPDLSHngkliyAAVT 115
Cdd:cd06174 22 LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFG-----RRPVLLLGLLLFALGALLFAFAPSFWL------LLLG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 116 YTLLTLLYTVVNIPYCALGGVITDnPTQRISLQSWRFVLATAGGMLSTVLMMPLVNFIGGEDKALGFqgGIAVLSVVAFL 195
Cdd:cd06174 91 RFLLGLGSGLIDPAVLALIADLFP-ERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFL--IAAALALLAAI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 196 MLAFCFFTTKERVEAPPSSTSMREDLRDIWRNDQWRVVGVLTILNILAVCVRGGAMMYYTTWI----MGSAALFTVFLTT 271
Cdd:cd06174 168 LLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLldlgGLSVAVAGLLLSL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 272 YCVGNLIGSALAKPLTDWKCKVSVFWWTNALLAVLSVAMFFVpMDAEITMFTFIFIIGVLHQLVTPIQWVMMSDTVDyge 351
Cdd:cd06174 248 FGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLL-APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP--- 323
|
330 340 350
....*....|....*....|....*....|....*...
gi 502732056 352 wcngKRLTGISFAGTLFVLKLGLALGGALIGWMLAGGG 389
Cdd:cd06174 324 ----PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| MFS_MFSD2 |
cd17392 |
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ... |
11-427 |
5.89e-10 |
|
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340950 Cd Length: 446 Bit Score: 60.95 E-value: 5.89e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 11 KIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLLARALDAISDPCMGLLADRT-RSRWGKFRPWILFgAIP 89
Cdd:cd17392 1 KLCYAIGGAPYQMTSSATGFFLQIFLLDVAQMGAFSVSLILFVGRVWDAVTDPLVGYFISRSqRTGIGRLMPWIVF-STP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 90 FG-LVCVLAYSSPDLSHnGKLIYAAVTYTLLTLLYTVVNIPYCALGGVITDNPTQRISLQSWRFVLATAGGMLSTVLMMP 168
Cdd:cd17392 80 LIiLAYFFLWFLPPFTS-LSGLWYLTFYCLFETFMTCFHVPYSALTMFLGGCQRERDSATAYRMTVEVFGTLMGATIQGQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 169 LVnfiGGEDK-----------------------ALGFQGGIAVLSVVAFLMLAFCFFTTKERVEapPSSTSMRED----- 220
Cdd:cd17392 159 IV---GVAHRprrqdctatpgtsdhpvtvlpntRRAYLIAALVVVVLYFVCCSILFLGVKEQPD--PLSPASGPGlsyla 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 221 -LRDIWRNDQWRVVGVLTILNILAVCVRGGAMMYYTTWIMGSAALFTVFLTTYcvgnLIGSALAKPLTDWKC-----KVS 294
Cdd:cd17392 234 gLKLVTGHPPYLKLVIGFLFSSLAFQMEQGNFVLFCTHAAGLGDHFQHLVLAI----LVSATLSIPLWQWVLqrrgkKTT 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 295 VFWWTNALLAVLSVaMFFVPMDAEITmFTFIFIIGVLHQLVTPIQWVMMSDTVDYGEWCN--GKRLTGISFAGTLFVLKL 372
Cdd:cd17392 310 SFIGISAMVPFLIL-LALVPSNLPVA-YVVAVVSGVSLAALFLLPWSMLPDVVDDFQLKNphCPGLEPIFYSCYVFFTKL 387
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 502732056 373 GLALGGALIGWMLAGGGYDAAAKTQNSATLTIIIALFTLVPAVCYLLSAVIAKRY 427
Cdd:cd17392 388 GGGLSLGISTLSLHFSGYKAGACKQPEEVVVTLKVLIAPVPICLILAGLVLFYVY 442
|
|
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
11-170 |
9.94e-08 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 54.05 E-value: 9.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 11 KIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLLARALDAISDPCMGLLADRTR-SRWGKFRPWILFgAIP 89
Cdd:cd17451 1 KLCYAIGGAPYQITGCALGFFLQIYLLDVAQLDPFYASIILFVGRAWDAITDPTVGFFVSKSPwTRFGRLMPWIIF-STP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 90 FGLVC-VLAYSSPDLSHnGKLIYAAVTYTLLTLLYTVVNIPYCALGGVITDNPTQRISLQSWRFVLATAGGMLSTVLMMP 168
Cdd:cd17451 80 FAVLSyFLIWFVPDFSQ-GKVMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVLGTAIQGQ 158
|
..
gi 502732056 169 LV 170
Cdd:cd17451 159 IV 160
|
|
| MFS_MFSD2B |
cd17452 |
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ... |
11-427 |
2.40e-07 |
|
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341010 Cd Length: 416 Bit Score: 52.90 E-value: 2.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 11 KIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLLARALDAISDPCMGLLAdrTRSRW---GKFRPWILfGA 87
Cdd:cd17452 1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFI--SKSKWtkiGRLMPWML-GC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 88 IPFGLVC-VLAYSSPDLShNGKLIYAAVTYTLLTLLYTVVNIPYCALGGVITDNPTQRISLQSWRFVLATAGGMLSTVLM 166
Cdd:cd17452 78 TPFIVVSyFFLWFVPPFT-TGRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTLVGAAVQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 167 MPLVnfiggedkALGFQGGIAVLSVVAFLMLAFCFFTTKERVE--APPS--STSMREDLRDIWRNDQWRVVGVLTILNIL 242
Cdd:cd17452 157 GQIV--------ASAYMIAAGVIGGLYLLCISVLFLGVKERDDpyAPKSgkAIPFFKGLSLTMRHGPYLKLTASFLFISA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 243 AVCVRGGAMMYYTTWIMGSAALFTVFLTTYcvgnLIGSALAKPLTDW-----KCKVSVFwwtnALLAVLSVAMFFVPMDA 317
Cdd:cd17452 229 AVQLEQSNFVLFCTHAVDLHDHFQNLVLTI----LVSAVVSIPFWQWflqrfGKKAAAC----GISWMIPFAIMLVTIPN 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 318 EITMFTFIFIIGVLHQLVTPIQWVMMSDTVDYGEWCN--GKRLTGISFAGTLFVLKLGLALGGALIGWMLAGGGYDAAAK 395
Cdd:cd17452 301 LIVAYVVAFVSGLSIAASLLLPWSMLPDVVDDFRLQNphGKGLETIFYSSYVFFTKLSAGIALGISTLSLEFAGYETGAC 380
|
410 420 430
....*....|....*....|....*....|..
gi 502732056 396 TQNSATLTIIIALFTLVPAVCYLLSAVIAKRY 427
Cdd:cd17452 381 KQPESVVLTLKLLIGAAPTCMILIGLCILMFY 412
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
154-347 |
2.45e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.12 E-value: 2.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 154 LATAGGMLSTVLMMPLVNFIGGedkALGFQGGIAVLSVVAFLMLAFCFFTTKERveAPPSSTSMREDLRDIWRNdqwRVV 233
Cdd:COG2814 138 LLGAGLGLGPALGPLLGGLLAD---LFGWRWVFLVNAVLALLALLLLLRLLPES--RPAARARLRGSLRELLRR---PRL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 234 GVLTILNILAVCVRGGAMMYYTTWIMG----SAALFTVFLTTYCVGNLIGSALAKPLTDWKCKVSVFWWTNALLAVLSVA 309
Cdd:COG2814 210 LLLLLLAFLLGFGFFALFTYLPLYLQEvlglSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLL 289
|
170 180 190
....*....|....*....|....*....|....*...
gi 502732056 310 MFFVPmdAEITMFTFIFIIGVLHQLVTPIQWVMMSDTV 347
Cdd:COG2814 290 LALAG--SLWLLLLALFLLGFGFGLLFPLLQALVAELA 325
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
235-419 |
3.35e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.02 E-value: 3.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 235 VLTILNILAVCVRGGAMMYYTTWIMG----SAALFTVFLTTYCVGNLIGSALAKPLTDW--KCKVSVFWWTNALLAVLSV 308
Cdd:COG2271 184 LLALAYFLVYFALYGFLTWLPTYLVEvrglSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlgRRRKLVLAIGLLLAALALL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 309 AMFFVPmdAEITMFTFIFIIGVLHQLVTPIQWVMMSDTVdygewcnGKRLTGISFAGTLFVLKLGLALGGALIGWMLAGG 388
Cdd:COG2271 264 LLALLP--SPALAIALLFLAGFGLGGAFGLLWALAAELF-------PKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334
|
170 180 190
....*....|....*....|....*....|.
gi 502732056 389 GYDAAAktqnsatltIIIALFTLVPAVCYLL 419
Cdd:COG2271 335 GYQAAF---------LLLAALALLAALLALL 356
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
154-418 |
4.81e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 42.15 E-value: 4.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 154 LATAGGMLSTVLMMPLVNFIGGedkALGFQGGIAVLSVVAFLMLAFCFFTTKERVEAPPSSTSMREDLRDIWRNDQWRVV 233
Cdd:cd17324 127 LVFSGLTLGLVLGRPLGGLLGQ---LLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 234 GVLTILNILAVcvrGGAMMYYTTWIM----GSAALFTVFLTTYCVGNLIGSALAKPLTDWKCKVSVFWWTNALLAVLSVA 309
Cdd:cd17324 204 YLITFLLFGGF---FALYTYLAPFLTdvpgFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLL 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 310 MFFVPmdAEITMFTFIFIIGVLHQLVTPIQWVMMSDTvdygewcnGKRLTGISFAGTLFVLKLGLALGGALIGWMLAGGG 389
Cdd:cd17324 281 TLLGP--SPLLLLVGLVLWGLGFFAAHSALQTRVLRL--------APEARGLASSLYLAAYNLGGALGAALGGLVLDHGG 350
|
250 260
....*....|....*....|....*....
gi 502732056 390 YdaaaktqnsATLTIIIALFTLVPAVCYL 418
Cdd:cd17324 351 W---------AGVGWVGAALLLLALLLAL 370
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
154-393 |
9.15e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.40 E-value: 9.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 154 LATAGGMLSTVLMMPLVNFIGGedkALGFQGGIAVLSVVAFLMLAFCFFTTKER-VEAPPSSTSMREDLRDIWRNDQWRV 232
Cdd:COG2223 133 LAAGGGNLGAAVAAFLAPLLIA---AFGWRNAFLILGILLLVVAVLAWLFLRDPpAGAAAAAKASLRDQLEALRDPRFWL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 233 VGVLTILNILA-VCVRGGAMMYYTTWIMGSAALFTVFLTTYCVGNLIGSALAKPLTDWKCKVSVFWWTNALLAVLSVAMF 311
Cdd:COG2223 210 LSLLYFGTFGSfIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLA 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 312 FVPMDAeITMFTFIFIIGVLHQLVTPIQWVMMSDTvdygewcNGKRLTGISFAGTLFVLKLGLALGGALIGWML-AGGGY 390
Cdd:COG2223 290 LALGSL-WLFLVLFLLLGLALGGGNGAVFALVPDI-------FPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLdATGSY 361
|
...
gi 502732056 391 DAA 393
Cdd:COG2223 362 TAA 364
|
|
| BT1 |
pfam03092 |
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative ... |
140-279 |
9.38e-04 |
|
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants, thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member of this family) was previously noted. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted prokaryotic proteins (from the cyanobacteria Synechocystis and Synechococcus).
Pssm-ID: 308617 Cd Length: 432 Bit Score: 41.56 E-value: 9.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 140 NPTQRISLQSWRFVLATAGGMLSTVLMMPLVnfiggedKALGFQGGIAVLSVVAFLMLAFCFFTTKER--VEAPPSSTSM 217
Cdd:pfam03092 118 SPTPGPSLQSWIWGCSAVGGIIGSVLSGPLL-------DTFKPQISFFVTAALQLLTCVVALLIKESSlgLPAKHEPKRP 190
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 502732056 218 -----------REDLRDIWRNDQWRVVGVLTIL-----NILAVCVRGGAMMYYTTWIMGSAALFTVFLTTYCVGNLIG 279
Cdd:pfam03092 191 vpclfglfemnREVISRNWKAFRYSEILTPTLFamlsqAILPLVIAKANVFFYTTNVLGPNFSYSFYGTVKVIGSIAG 268
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
40-88 |
1.59e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 40.69 E-value: 1.59e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 502732056 40 FGIPAGFVGTMFLLARALDAISDPCMGLLADRTRSRWGKFRPWILFGAI 88
Cdd:cd17313 29 LGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAP 77
|
|
| MFS_MFSD12 |
cd17491 |
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ... |
11-216 |
1.82e-03 |
|
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341044 Cd Length: 438 Bit Score: 40.70 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 11 KIGYGMGdaasHIIFDnvmLY--MMFFYTDIF-----GIPAGFVGTMFLLARALDAISDPCMGLLADRTRSRW--GKFRP 81
Cdd:cd17491 1 RIAYGVG----HVLND---LCasMWFTYLLVYfhlvlGFSSALAGILLLIGQVADAISTPLVGYESDRTNGCGkyGRRKS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 82 WILFG------AIPFGLVCVLAYsSPDLSHNGKLIYAAVTYTLLTLLYTVVNIPYCALGGVITDNPTQRISLQSWRFVLA 155
Cdd:cd17491 74 WHLIGticvllSFPFIFNPCLGC-SDSTSEWAKLVYYGPFIIIFQFGWAAVQISHLSLIPELTSDEHERVELTALRYAFT 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 502732056 156 TAGGMLSTVLMMPLVNFIGGEDKALGFQG--------GIAVLSVVAFLMLAFCFFTTKERVEAPPSSTS 216
Cdd:cd17491 153 VIANITVYLIAWLLLQQSSGDSVNPTSAQdlpifrnlSLIVVGIGFLFSLLFHLGTKEPRPPTDLSTTT 221
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
179-412 |
2.83e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.91 E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 179 ALGFQGGIAVLSVVAFLMLAFCFFTTKERVEAPPSSTS-----MREDLRDIWRNDQWRVVGVLTILNILAVC-VRGGAMM 252
Cdd:cd06173 154 LLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSlllrdLREGLRYLRRSPLLRLLLLALALFALLGGaLTVLLPL 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 253 YYTTWIMGSAALFTVFLTTYCVGNLIGSALAKPLTDWKCKVSVFWWTNALLAVLSVAMFFVPMDaeITMFTFIFIIGVLH 332
Cdd:cd06173 234 LAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSL--WLLLAALFLLGLAG 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 333 QLVTPIQWVMMSDTVDygewcngKRLTGISFAGTLFVLKLGLALGGALIGWMLAGGGYDAAakTQNSATLTIIIALFTLV 412
Cdd:cd06173 312 GLFNVPLNTLLQLRVP-------DELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAV--FLLAGALLLLAALLLLL 382
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
154-347 |
2.97e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 2.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 154 LATAGGMLSTVLMMPLVNFIGGedkALGFQGGIAVLSVVAFLMLAFCFFTTKERVEAPPSSTSMREDLRDIWRNDQWRVV 233
Cdd:pfam07690 125 LVSAGFGLGAALGPLLGGLLAS---LFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDP 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 234 GVLTILNILAVCVRGGAMMYYTTWIMG----SAALFTVFLTTYCVGNLIGSALAKPLTDWKCKVSVFWWTNALLAVLSVA 309
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEvlglSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281
|
170 180 190
....*....|....*....|....*....|....*....
gi 502732056 310 MFFVPMDAEITMF-TFIFIIGVLHQLVTPIQWVMMSDTV 347
Cdd:pfam07690 282 LLLLSLTLSSLWLlLALLLLGFGFGLVFPALNALVSDLA 320
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
154-390 |
4.08e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 39.48 E-value: 4.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 154 LATAGGMLSTVLMMPLVNFIggeDKALGFQGGIAVLSVVAFLMLAFCFFTTKERVEAPPSSTSMREDLRDIWRNDQWRVV 233
Cdd:cd17325 124 IFSSAIGLGFLIGPLLGGLL---ADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRR 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 234 GVLTILNILAVCVRGGAM-----MYYTTWIMGSAALFTVFLTTYCVGNLIGSALAKPLTDWKCKVSVFWWTNALLAVLSV 308
Cdd:cd17325 201 LLALFLAIFVLAFAFGALepflpLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502732056 309 AMFFVPmdAEITMFTFIFIIGVLHQLVTPIQWVMMSDTVDygewcngKRLTGISFAGTLFVLKLGLALGGALIGWMLAGG 388
Cdd:cd17325 281 LLPLAT--SFWLLLLLLALLGLGLGLVFPATLALLADIVP-------PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF 351
|
..
gi 502732056 389 GY 390
Cdd:cd17325 352 GF 353
|
|
| |
