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Conserved domains on  [gi|502626625|ref|WP_012863340|]
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S24 family peptidase [Sebaldella termitidis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2932 COG2932
Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: ...
 133-220 3.40e-08

Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: prophages, transposons];


:

Pssm-ID: 442176  Cd Length: 121  Bit Score: 50.35  E-value: 3.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502626625 133 KNNISVNISGNLMQPFFFEGDKILIKKEELTVwgdLNRKIILYKLDNKFYLRKVLFI-DGKGYLEAFNKDvYGKFEID-- 209
Cdd:COG2932   33 DNLFAVRVSGDSMEPTIRDGDIVLVDPSDTEI---RDGGIYVVRTDGELLVKRLQRRpDGKLRLISDNPA-YPPIEIPpe 108

                         90
                 ....*....|...
gi 502626625 210 --SKVKYIGRVVK 220
Cdd:COG2932  109 daDEIEIIGRVVW 121
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
7-67 4.55e-05

DNA-binding transcriptional regulator, XRE family [Transcription];


:

Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 40.51  E-value: 4.55e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502626625   7 LRELISKKRRSKnlarekvSELlkIEGIEYAESSLTRFENGKIKNIRIEILNALCDILDID 67
Cdd:COG3655    6 LDELLAERGMTK-------KEL--AEATGISRATLSRLKNGKAKAVRLDTLEKICKALDCQ 57
 
Name Accession Description Interval E-value
COG2932 COG2932
Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: ...
 133-220 3.40e-08

Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: prophages, transposons];


Pssm-ID: 442176  Cd Length: 121  Bit Score: 50.35  E-value: 3.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502626625 133 KNNISVNISGNLMQPFFFEGDKILIKKEELTVwgdLNRKIILYKLDNKFYLRKVLFI-DGKGYLEAFNKDvYGKFEID-- 209
Cdd:COG2932   33 DNLFAVRVSGDSMEPTIRDGDIVLVDPSDTEI---RDGGIYVVRTDGELLVKRLQRRpDGKLRLISDNPA-YPPIEIPpe 108

                         90
                 ....*....|...
gi 502626625 210 --SKVKYIGRVVK 220
Cdd:COG2932  109 daDEIEIIGRVVW 121
Peptidase_S24 pfam00717
Peptidase S24-like;
138-219 1.49e-05

Peptidase S24-like;


Pssm-ID: 425835  Cd Length: 116  Bit Score: 42.96  E-value: 1.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502626625  138 VNISGNLMQPFFFEGDKILIKKEELTVWGDlnrkIILYKLDNKFYLRKVLFIDGKGYLEAFNKDvYG--KFEIDSKVKYI 215
Cdd:pfam00717  38 LRVKGDSMEPGIPDGDLVLVDPSREARNGD----IVVARLDGEATVKRLYRDGGGIRLISLNPE-YPpiELPAEDDVEII 112


                  ....
gi 502626625  216 GRVV 219
Cdd:pfam00717 113 GRVV 116
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
7-67 4.55e-05

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 40.51  E-value: 4.55e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502626625   7 LRELISKKRRSKnlarekvSELlkIEGIEYAESSLTRFENGKIKNIRIEILNALCDILDID 67
Cdd:COG3655    6 LDELLAERGMTK-------KEL--AEATGISRATLSRLKNGKAKAVRLDTLEKICKALDCQ 57
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 7-67 2.25e-04

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 38.29  E-value: 2.25e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502626625    7 LRELISKKR-RSKNLARekvsellkieGIEYAESSLTRFENGKIKNIRIEILNALCDILDID 67
Cdd:pfam13443   2 LRKLMADRGiSKSDLAR----------ATGISRATLSRLRKGKPKRVSLDTLDKICDALGCQ 53
S24_LexA-like cd06529
Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of ...
 138-219 6.11e-04

Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The LexA-like proteins contain two-domains: an N-terminal DNA binding domain and a C-terminal domain (CTD) that provides LexA dimerization as well as cleavage activity. They undergo autolysis, cleaving at an Ala-Gly or a Cys-Gly bond, separating the DNA-binding domain from the rest of the protein. In the presence of single-stranded DNA, the LexA, UmuD and MucA proteins interact with RecA, activating self cleavage, thus either derepressing transcription in the case of LexA or activating the lesion-bypass polymerase in the case of UmuD and MucA. The LexA proteins are serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases. LexA sequence homologs are found in almost all of the bacterial genomes sequenced to date, covering a large number of phyla, suggesting both, an ancient origin and a widespread distribution of lexA and the SOS response.


Pssm-ID: 119397 [Multi-domain]  Cd Length: 81  Bit Score: 37.54  E-value: 6.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502626625 138 VNISGNLMQPFFFEGDKILIKKEELTVwgdlNRKIILYKLDNKFYLrKVLFIDGKG--YLEAFNKDvYGKFEID-SKVKY 214
Cdd:cd06529    3 LRVKGDSMEPTIPDGDLVLVDPSDTPR----DGDIVVARLDGELTV-KRLQRRGGGrlRLISDNPA-YPPIEIDeEELEI 76


                 ....*
gi 502626625 215 IGRVV 219
Cdd:cd06529   77 VGVVG 81
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 9-70 1.26e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 35.99  E-value: 1.26e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502626625   9 ELISKKRRSKNLAREKVSELLKIegieyAESSLTRFENGKIkNIRIEILNALCDILDIDKKE 70
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGV-----SRSTISRIENGKR-NPSLETLEKLAKALGVSLDE 57
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
11-67 2.70e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 35.19  E-value: 2.70e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 502626625    11 ISKKRRSKNLAREKVSELLKIegieyAESSLTRFENGKIKnIRIEILNALCDILDID 67
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGV-----SRSTLSRIENGKRK-PSLETLKKLAKALGVS 52
 
Name Accession Description Interval E-value
COG2932 COG2932
Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: ...
 133-220 3.40e-08

Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: prophages, transposons];


Pssm-ID: 442176  Cd Length: 121  Bit Score: 50.35  E-value: 3.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502626625 133 KNNISVNISGNLMQPFFFEGDKILIKKEELTVwgdLNRKIILYKLDNKFYLRKVLFI-DGKGYLEAFNKDvYGKFEID-- 209
Cdd:COG2932   33 DNLFAVRVSGDSMEPTIRDGDIVLVDPSDTEI---RDGGIYVVRTDGELLVKRLQRRpDGKLRLISDNPA-YPPIEIPpe 108

                         90
                 ....*....|...
gi 502626625 210 --SKVKYIGRVVK 220
Cdd:COG2932  109 daDEIEIIGRVVW 121
Peptidase_S24 pfam00717
Peptidase S24-like;
138-219 1.49e-05

Peptidase S24-like;


Pssm-ID: 425835  Cd Length: 116  Bit Score: 42.96  E-value: 1.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502626625  138 VNISGNLMQPFFFEGDKILIKKEELTVWGDlnrkIILYKLDNKFYLRKVLFIDGKGYLEAFNKDvYG--KFEIDSKVKYI 215
Cdd:pfam00717  38 LRVKGDSMEPGIPDGDLVLVDPSREARNGD----IVVARLDGEATVKRLYRDGGGIRLISLNPE-YPpiELPAEDDVEII 112


                  ....
gi 502626625  216 GRVV 219
Cdd:pfam00717 113 GRVV 116
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
7-67 4.55e-05

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 40.51  E-value: 4.55e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 502626625   7 LRELISKKRRSKnlarekvSELlkIEGIEYAESSLTRFENGKIKNIRIEILNALCDILDID 67
Cdd:COG3655    6 LDELLAERGMTK-------KEL--AEATGISRATLSRLKNGKAKAVRLDTLEKICKALDCQ 57
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 7-67 2.25e-04

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 38.29  E-value: 2.25e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502626625    7 LRELISKKR-RSKNLARekvsellkieGIEYAESSLTRFENGKIKNIRIEILNALCDILDID 67
Cdd:pfam13443   2 LRKLMADRGiSKSDLAR----------ATGISRATLSRLRKGKPKRVSLDTLDKICDALGCQ 53
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 5-67 2.64e-04

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 38.28  E-value: 2.64e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 502626625    5 EQLRELiskkRRSKNLAREKVSELLkiegiEYAESSLTRFENGKIKNIRIEILNALCDILDID 67
Cdd:pfam13560   4 ARLRRL----RERAGLSQEALARRL-----GVSRSTLSRLETGRRGRPSPAVVERLARALGVD 57
S24_LexA-like cd06529
Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of ...
 138-219 6.11e-04

Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The LexA-like proteins contain two-domains: an N-terminal DNA binding domain and a C-terminal domain (CTD) that provides LexA dimerization as well as cleavage activity. They undergo autolysis, cleaving at an Ala-Gly or a Cys-Gly bond, separating the DNA-binding domain from the rest of the protein. In the presence of single-stranded DNA, the LexA, UmuD and MucA proteins interact with RecA, activating self cleavage, thus either derepressing transcription in the case of LexA or activating the lesion-bypass polymerase in the case of UmuD and MucA. The LexA proteins are serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases. LexA sequence homologs are found in almost all of the bacterial genomes sequenced to date, covering a large number of phyla, suggesting both, an ancient origin and a widespread distribution of lexA and the SOS response.


Pssm-ID: 119397 [Multi-domain]  Cd Length: 81  Bit Score: 37.54  E-value: 6.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502626625 138 VNISGNLMQPFFFEGDKILIKKEELTVwgdlNRKIILYKLDNKFYLrKVLFIDGKG--YLEAFNKDvYGKFEID-SKVKY 214
Cdd:cd06529    3 LRVKGDSMEPTIPDGDLVLVDPSDTPR----DGDIVVARLDGELTV-KRLQRRGGGrlRLISDNPA-YPPIEIDeEELEI 76


                 ....*
gi 502626625 215 IGRVV 219
Cdd:cd06529   77 VGVVG 81
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 9-70 1.26e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 35.99  E-value: 1.26e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 502626625   9 ELISKKRRSKNLAREKVSELLKIegieyAESSLTRFENGKIkNIRIEILNALCDILDIDKKE 70
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGV-----SRSTISRIENGKR-NPSLETLEKLAKALGVSLDE 57
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
11-67 2.70e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 35.19  E-value: 2.70e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 502626625    11 ISKKRRSKNLAREKVSELLKIegieyAESSLTRFENGKIKnIRIEILNALCDILDID 67
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGV-----SRSTLSRIENGKRK-PSLETLKKLAKALGVS 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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