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Conserved domains on  [gi|501636992|ref|WP_012608000|]
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bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC [Desulfurococcus amylolyticus]

Protein Classification

phosphopantothenoylcysteine synthetase/decarboxylase family protein( domain architecture ID 1008203)

bifunctional phosphopantothenoylcysteine synthetase/decarboxylase (CoaBC) family protein similar to Staphylococcus epidermidis peptidyl-cysteine decarboxylase EpiD and Streptomyces olivoviridis FMN-dependent cysteine decarboxylase

CATH:  3.40.50.1950
Gene Ontology:  GO:0010181
PubMed:  10922366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CoaBC super family cl33883
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 14-405 3.98e-104

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


The actual alignment was detected with superfamily member COG0452:

Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 313.50  E-value: 3.98e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  14 LQGRNILLGLTASSSIYKSIDLARRLIRMGGNLRVVMTRRSLSLIG-------------VDLvhWATgskpfyEMSGETE 80
Cdd:COG0452    2 LAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTpltfqalsgnpvyTDL--FDE------EAEAEMG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  81 HIDLAQWADAMVIAPATLNTMGKIAYGILDELLTltaTTMMGSSKKVIIVPAMNIRlMsspqYKNAA-----GKLEEYGA 155
Cdd:COG0452   74 HIELARWADLIVIAPATANTIAKLAHGIADDLLT---TTLLATTCPVLVAPAMNTN-M----WEHPAtqrnlATLRERGV 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 156 VIIPPLI------EEDKAKYPPLDDLSHCIDAIVNRGVDLKNRRILVTAGPTREYLDPVRVITNPSSGLMGVLIARELAC 229
Cdd:COG0452  146 HIIGPASgelacgDVGKGRMAEPEEIVEAIEALLAPKKDLAGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAA 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 230 RGARVDLVHGPMTVKPPYLVKSIHVETTSDMADKIRELTNETiyDAAVFAAAPADYKPASSSPEKISTRDKPyLEVRLEQ 309
Cdd:COG0452  226 RGAEVTLVSGPVALPTPAGVERIDVESAEEMLEAVLAAFPDA--DIVIMAAAVADYRPAEVADQKIKKTDDP-LTLELVK 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 310 TP---KTIKSIANRPRILVAFAAETcggEKLVEKTLLKASDYGADLVIGNNVLSSEAGFGKEMLEIVAV-AEGGIMDRGT 385
Cdd:COG0452  303 NPdilAELGARKKPGQFLVGFAAET---ENLLENARAKLARKNLDLIVANDVSDAGAGFGSDTNAVTLLdKDGREEELPL 379

                        410       420
                 ....*....|....*....|
gi 501636992 386 RFKPEVARIIGDFISRRLQA 405
Cdd:COG0452  380 MSKLEVARRILDEIAELLAA 399
 
Name Accession Description Interval E-value
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 14-405 3.98e-104

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 313.50  E-value: 3.98e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  14 LQGRNILLGLTASSSIYKSIDLARRLIRMGGNLRVVMTRRSLSLIG-------------VDLvhWATgskpfyEMSGETE 80
Cdd:COG0452    2 LAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTpltfqalsgnpvyTDL--FDE------EAEAEMG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  81 HIDLAQWADAMVIAPATLNTMGKIAYGILDELLTltaTTMMGSSKKVIIVPAMNIRlMsspqYKNAA-----GKLEEYGA 155
Cdd:COG0452   74 HIELARWADLIVIAPATANTIAKLAHGIADDLLT---TTLLATTCPVLVAPAMNTN-M----WEHPAtqrnlATLRERGV 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 156 VIIPPLI------EEDKAKYPPLDDLSHCIDAIVNRGVDLKNRRILVTAGPTREYLDPVRVITNPSSGLMGVLIARELAC 229
Cdd:COG0452  146 HIIGPASgelacgDVGKGRMAEPEEIVEAIEALLAPKKDLAGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAA 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 230 RGARVDLVHGPMTVKPPYLVKSIHVETTSDMADKIRELTNETiyDAAVFAAAPADYKPASSSPEKISTRDKPyLEVRLEQ 309
Cdd:COG0452  226 RGAEVTLVSGPVALPTPAGVERIDVESAEEMLEAVLAAFPDA--DIVIMAAAVADYRPAEVADQKIKKTDDP-LTLELVK 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 310 TP---KTIKSIANRPRILVAFAAETcggEKLVEKTLLKASDYGADLVIGNNVLSSEAGFGKEMLEIVAV-AEGGIMDRGT 385
Cdd:COG0452  303 NPdilAELGARKKPGQFLVGFAAET---ENLLENARAKLARKNLDLIVANDVSDAGAGFGSDTNAVTLLdKDGREEELPL 379

                        410       420
                 ....*....|....*....|
gi 501636992 386 RFKPEVARIIGDFISRRLQA 405
Cdd:COG0452  380 MSKLEVARRILDEIAELLAA 399
PRK05579 PRK05579
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
 11-405 1.48e-103

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 312.07  E-value: 1.48e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  11 HQPLQGRNILLGLTASSSIYKSIDLARRLIRMGGNLRVVMTRRSLSLIGVDLVHWATGSKPFYEM-----SGETEHIDLA 85
Cdd:PRK05579   1 MRMLAGKRIVLGVSGGIAAYKALELVRRLRKAGADVRVVMTEAAKKFVTPLTFQALSGNPVSTDLwdpaaEAAMGHIELA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  86 QWADAMVIAPATLNTMGKIAYGILDELLTLTATTmmgSSKKVIIVPAMNIRLMSSPQYKNAAGKLEEYGAVIIPPL---- 161
Cdd:PRK05579  81 KWADLVLIAPATADLIAKLAHGIADDLLTTTLLA---TTAPVLVAPAMNTQMWENPATQRNLATLRSRGVEIIGPAsgrl 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 162 --IEEDKAKYP-PLDDLSHCIDAIVNRgvDLKNRRILVTAGPTREYLDPVRVITNPSSGLMGVLIARELACRGARVDLVH 238
Cdd:PRK05579 158 acGDVGPGRMAePEEIVAAAERALSPK--DLAGKRVLITAGPTREPIDPVRYITNRSSGKMGYALARAAARRGADVTLVS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 239 GPMTVKPPYLVKSIHVETTSDMADKIRELTNEtiYDAAVFAAAPADYKPASSSPEKI-STRDKPYLEvrLEQTPKTIKSI 317
Cdd:PRK05579 236 GPVNLPTPAGVKRIDVESAQEMLDAVLAALPQ--ADIFIMAAAVADYRPATVAEGKIkKGEGELTLE--LVPNPDILAEV 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 318 A---NRPRILVAFAAETCGGEKLVEKTLLKAsdyGADLVIGNNVlSSEAGFGKEMLEIVAVAEGGIMDRGTRF-KPEVAR 393
Cdd:PRK05579 312 AalkDKRPFVVGFAAETGDVLEYARAKLKRK---GLDLIVANDV-SAGGGFGSDDNEVTLIWSDGGEVKLPLMsKLELAR 387

                        410
                 ....*....|..
gi 501636992 394 IIGDFISRRLQA 405
Cdd:PRK05579 388 RLLDEIAERLLE 399
coaBC_dfp TIGR00521
phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model ...
 14-399 7.57e-84

phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model represents a bifunctional enzyme that catalyzes the second and third steps (cysteine ligation, EC 6.3.2.5, and decarboxylation, EC 4.1.1.36) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. In early descriptions of this flavoprotein, a ts mutation in one region of the protein appeared to cause a defect in DNA metaobolism rather than an increased need for the pantothenate precursor beta-alanine. This protein was then called dfp, for DNA/pantothenate metabolism flavoprotein. The authors responsible for detecting phosphopantothenate--cysteine ligase activity suggest renaming this bifunctional protein coaBC for its role in CoA biosynthesis. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region contains the phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273116 [Multi-domain]  Cd Length: 391  Bit Score: 261.15  E-value: 7.57e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992   14 LQGRNILLGLTASSSIYKSIDLARRLIRMGGNLRVVMTRRSLSLIGVDLVHWATGSKPFYEMSGETEH----IDLAQWAD 89
Cdd:TIGR00521   1 LENKKILLGVTGGIAAYKTVELVRELVRQGAEVKVIMTEAAKKFITPLTLEALSGHKVVTELWGPIEHnalhIDLAKWAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992   90 AMVIAPATLNTMGKIAYGILDELLTLTATTmmgSSKKVIIVPAMNIRLMSSPQYKNAAGKLEEYGAVIIPP------LIE 163
Cdd:TIGR00521  81 LILIAPATANTISKIAHGIADDLVSTTALA---ASAPIILAPAMNENMYNNPAVQENIKRLKDDGYIFIEPrsgllaCGD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  164 EDKAKYPPLDDLSHCIDAIVNRGVDLKNRRILVTAGPTREYLDPVRVITNPSSGLMGVLIARELACRGARVDLVHGPMTV 243
Cdd:TIGR00521 158 EGKGRLAEPETIVKAAEREFSPKEDLEGKRVLITAGPTREPIDPVRFISNLSSGKMGLALAEAAYKRGADVTLITGPVSL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  244 KPPYLVKSIHVETTSDMADK-IRELTNEtiYDAAVFAAAPADYKPASSSPEKISTRDKPyLEVRLEQTPKTIKSIA--NR 320
Cdd:TIGR00521 238 LTPPGVKSIKVSTAEEMLEAaLNELAKD--FDIFISAAAVADFKPKTVFEGKIKKQGEE-LSLKLVKNPDIIAEVRkiKK 314

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501636992  321 PRILVAFAAETcgGEKLVEKTLLKASDYGADLVIGNNVlSSEAGFGKEMLEIVAVAEGGIMDRGTRFKPEVARIIGDFI 399
Cdd:TIGR00521 315 HQVIVGFKAET--NDDLIKYAKEKLKKKNLDMIVANDV-SQGRGFGSDENEVYIFSKHGHKELPLMSKLEVAERILDEI 390
DFP pfam04127
DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4. ...
 189-368 1.35e-61

DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.


Pssm-ID: 461186 [Multi-domain]  Cd Length: 183  Bit Score: 196.86  E-value: 1.35e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  189 LKNRRILVTAGPTREYLDPVRVITNPSSGLMGVLIARELACRGARVDLVHGPMTVKPPYLVKSIHVETTSDMADKIRELT 268
Cdd:pfam04127   1 LAGKRVLVTAGPTREPIDPVRFISNRSSGKMGYALARAAAARGAEVTLVSGPTSLPPPPGVEVVDVESAEEMLEAVLAAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  269 NEtiYDAAVFAAAPADYKPASSSPEKIS-TRDKPYLEVRLEQTPKTIKSIANR--PRILVAFAAETcggEKLVEKTLLKA 345
Cdd:pfam04127  81 PE--ADIVIMAAAVADYRPAEVADGKIKkSSGGEELTLELVKNPDILAELGKRkpGQLLVGFAAET---EDLLENARAKL 155

                         170       180
                  ....*....|....*....|...
gi 501636992  346 SDYGADLVIGNNVLSSEAGFGKE 368
Cdd:pfam04127 156 ERKNLDLIVANDVSRPGAGFGSD 178
 
Name Accession Description Interval E-value
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 14-405 3.98e-104

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 313.50  E-value: 3.98e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  14 LQGRNILLGLTASSSIYKSIDLARRLIRMGGNLRVVMTRRSLSLIG-------------VDLvhWATgskpfyEMSGETE 80
Cdd:COG0452    2 LAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTpltfqalsgnpvyTDL--FDE------EAEAEMG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  81 HIDLAQWADAMVIAPATLNTMGKIAYGILDELLTltaTTMMGSSKKVIIVPAMNIRlMsspqYKNAA-----GKLEEYGA 155
Cdd:COG0452   74 HIELARWADLIVIAPATANTIAKLAHGIADDLLT---TTLLATTCPVLVAPAMNTN-M----WEHPAtqrnlATLRERGV 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 156 VIIPPLI------EEDKAKYPPLDDLSHCIDAIVNRGVDLKNRRILVTAGPTREYLDPVRVITNPSSGLMGVLIARELAC 229
Cdd:COG0452  146 HIIGPASgelacgDVGKGRMAEPEEIVEAIEALLAPKKDLAGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAA 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 230 RGARVDLVHGPMTVKPPYLVKSIHVETTSDMADKIRELTNETiyDAAVFAAAPADYKPASSSPEKISTRDKPyLEVRLEQ 309
Cdd:COG0452  226 RGAEVTLVSGPVALPTPAGVERIDVESAEEMLEAVLAAFPDA--DIVIMAAAVADYRPAEVADQKIKKTDDP-LTLELVK 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 310 TP---KTIKSIANRPRILVAFAAETcggEKLVEKTLLKASDYGADLVIGNNVLSSEAGFGKEMLEIVAV-AEGGIMDRGT 385
Cdd:COG0452  303 NPdilAELGARKKPGQFLVGFAAET---ENLLENARAKLARKNLDLIVANDVSDAGAGFGSDTNAVTLLdKDGREEELPL 379

                        410       420
                 ....*....|....*....|
gi 501636992 386 RFKPEVARIIGDFISRRLQA 405
Cdd:COG0452  380 MSKLEVARRILDEIAELLAA 399
PRK05579 PRK05579
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
 11-405 1.48e-103

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 312.07  E-value: 1.48e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  11 HQPLQGRNILLGLTASSSIYKSIDLARRLIRMGGNLRVVMTRRSLSLIGVDLVHWATGSKPFYEM-----SGETEHIDLA 85
Cdd:PRK05579   1 MRMLAGKRIVLGVSGGIAAYKALELVRRLRKAGADVRVVMTEAAKKFVTPLTFQALSGNPVSTDLwdpaaEAAMGHIELA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  86 QWADAMVIAPATLNTMGKIAYGILDELLTLTATTmmgSSKKVIIVPAMNIRLMSSPQYKNAAGKLEEYGAVIIPPL---- 161
Cdd:PRK05579  81 KWADLVLIAPATADLIAKLAHGIADDLLTTTLLA---TTAPVLVAPAMNTQMWENPATQRNLATLRSRGVEIIGPAsgrl 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 162 --IEEDKAKYP-PLDDLSHCIDAIVNRgvDLKNRRILVTAGPTREYLDPVRVITNPSSGLMGVLIARELACRGARVDLVH 238
Cdd:PRK05579 158 acGDVGPGRMAePEEIVAAAERALSPK--DLAGKRVLITAGPTREPIDPVRYITNRSSGKMGYALARAAARRGADVTLVS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 239 GPMTVKPPYLVKSIHVETTSDMADKIRELTNEtiYDAAVFAAAPADYKPASSSPEKI-STRDKPYLEvrLEQTPKTIKSI 317
Cdd:PRK05579 236 GPVNLPTPAGVKRIDVESAQEMLDAVLAALPQ--ADIFIMAAAVADYRPATVAEGKIkKGEGELTLE--LVPNPDILAEV 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 318 A---NRPRILVAFAAETCGGEKLVEKTLLKAsdyGADLVIGNNVlSSEAGFGKEMLEIVAVAEGGIMDRGTRF-KPEVAR 393
Cdd:PRK05579 312 AalkDKRPFVVGFAAETGDVLEYARAKLKRK---GLDLIVANDV-SAGGGFGSDDNEVTLIWSDGGEVKLPLMsKLELAR 387

                        410
                 ....*....|..
gi 501636992 394 IIGDFISRRLQA 405
Cdd:PRK05579 388 RLLDEIAERLLE 399
coaBC_dfp TIGR00521
phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model ...
 14-399 7.57e-84

phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model represents a bifunctional enzyme that catalyzes the second and third steps (cysteine ligation, EC 6.3.2.5, and decarboxylation, EC 4.1.1.36) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. In early descriptions of this flavoprotein, a ts mutation in one region of the protein appeared to cause a defect in DNA metaobolism rather than an increased need for the pantothenate precursor beta-alanine. This protein was then called dfp, for DNA/pantothenate metabolism flavoprotein. The authors responsible for detecting phosphopantothenate--cysteine ligase activity suggest renaming this bifunctional protein coaBC for its role in CoA biosynthesis. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region contains the phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273116 [Multi-domain]  Cd Length: 391  Bit Score: 261.15  E-value: 7.57e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992   14 LQGRNILLGLTASSSIYKSIDLARRLIRMGGNLRVVMTRRSLSLIGVDLVHWATGSKPFYEMSGETEH----IDLAQWAD 89
Cdd:TIGR00521   1 LENKKILLGVTGGIAAYKTVELVRELVRQGAEVKVIMTEAAKKFITPLTLEALSGHKVVTELWGPIEHnalhIDLAKWAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992   90 AMVIAPATLNTMGKIAYGILDELLTLTATTmmgSSKKVIIVPAMNIRLMSSPQYKNAAGKLEEYGAVIIPP------LIE 163
Cdd:TIGR00521  81 LILIAPATANTISKIAHGIADDLVSTTALA---ASAPIILAPAMNENMYNNPAVQENIKRLKDDGYIFIEPrsgllaCGD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  164 EDKAKYPPLDDLSHCIDAIVNRGVDLKNRRILVTAGPTREYLDPVRVITNPSSGLMGVLIARELACRGARVDLVHGPMTV 243
Cdd:TIGR00521 158 EGKGRLAEPETIVKAAEREFSPKEDLEGKRVLITAGPTREPIDPVRFISNLSSGKMGLALAEAAYKRGADVTLITGPVSL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  244 KPPYLVKSIHVETTSDMADK-IRELTNEtiYDAAVFAAAPADYKPASSSPEKISTRDKPyLEVRLEQTPKTIKSIA--NR 320
Cdd:TIGR00521 238 LTPPGVKSIKVSTAEEMLEAaLNELAKD--FDIFISAAAVADFKPKTVFEGKIKKQGEE-LSLKLVKNPDIIAEVRkiKK 314

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501636992  321 PRILVAFAAETcgGEKLVEKTLLKASDYGADLVIGNNVlSSEAGFGKEMLEIVAVAEGGIMDRGTRFKPEVARIIGDFI 399
Cdd:TIGR00521 315 HQVIVGFKAET--NDDLIKYAKEKLKKKNLDMIVANDV-SQGRGFGSDENEVYIFSKHGHKELPLMSKLEVAERILDEI 390
DFP pfam04127
DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4. ...
 189-368 1.35e-61

DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.


Pssm-ID: 461186 [Multi-domain]  Cd Length: 183  Bit Score: 196.86  E-value: 1.35e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  189 LKNRRILVTAGPTREYLDPVRVITNPSSGLMGVLIARELACRGARVDLVHGPMTVKPPYLVKSIHVETTSDMADKIRELT 268
Cdd:pfam04127   1 LAGKRVLVTAGPTREPIDPVRFISNRSSGKMGYALARAAAARGAEVTLVSGPTSLPPPPGVEVVDVESAEEMLEAVLAAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  269 NEtiYDAAVFAAAPADYKPASSSPEKIS-TRDKPYLEVRLEQTPKTIKSIANR--PRILVAFAAETcggEKLVEKTLLKA 345
Cdd:pfam04127  81 PE--ADIVIMAAAVADYRPAEVADGKIKkSSGGEELTLELVKNPDILAELGKRkpGQLLVGFAAET---EDLLENARAKL 155

                         170       180
                  ....*....|....*....|...
gi 501636992  346 SDYGADLVIGNNVLSSEAGFGKE 368
Cdd:pfam04127 156 ERKNLDLIVANDVSRPGAGFGSD 178
PRK13982 PRK13982
bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; ...
 13-358 9.63e-47

bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional


Pssm-ID: 172484 [Multi-domain]  Cd Length: 475  Bit Score: 166.47  E-value: 9.63e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  13 PLQGRNILLGLTASSSIYKSIDLARRLIRMGGNLRVVMTRRSLSLIgVDLVHWATGSKPFYE--MSGETE----HIDLAQ 86
Cdd:PRK13982  67 SLASKRVTLIIGGGIAAYKALDLIRRLKERGAHVRCVLTKAAQQFV-TPLTASALSGQRVYTdlFDPESEfdagHIRLAR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  87 WADAMVIAPATLNTMGKIAYGILDELLTltaTTMMGSSKKVIIVPAMNIRLMSSPQYKNAAGKLEEYGAVIIPP----LI 162
Cdd:PRK13982 146 DCDLIVVAPATADLMAKMANGLADDLAS---AILLAANRPILLAPAMNPLMWNNPATRRNVAQLKRDGVHMIGPnageMA 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 163 EEDKAKYPPLDDLSHCIDAIVN-----RGVDLKNRRILVTAGPTREYLDPVRVITNPSSGLMGVLIARELACRGARVDLV 237
Cdd:PRK13982 223 ERGEAGVGRMAEPLEIAAAAEAllrppQPKPLAGRRVLITAGPTHEPIDPVRYIANRSSGKQGFAIAAAAAAAGAEVTLI 302

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 238 HGPMTVKPPYLVKSIHVETTSDMADKIREltnETIYDAAVFAAAPADYKPASSSPEKISTRDKPYLEVRLEQTPKTIKSI 317
Cdd:PRK13982 303 SGPVDLADPQGVKVIHVESARQMLAAVEA---ALPADIAIFAAAVADWRVATEGGQKLKKGAAGPPPLQLVENPDILATI 379

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 501636992 318 A----NRPRILVAFAAETCggeKLVEKTLLKASDYGADLVIGNNV 358
Cdd:PRK13982 380 SklaeNRPPLVIGFAAETE---HLIDNARAKLARKGCDWIVANDV 421
Flavoprotein pfam02441
Flavoprotein; This family contains diverse flavoprotein enzymes. This family includes ...
 17-164 4.34e-32

Flavoprotein; This family contains diverse flavoprotein enzymes. This family includes epidermin biosynthesis protein, EpiD, which has been shown to be a flavoprotein that binds FMN. This enzyme catalyzes the removal of two reducing equivalents from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond. This family also includes the B chain of dipicolinate synthase a small polar molecule that accumulates to high concentrations in bacterial endospores, and is thought to play a role in spore heat resistance, or the maintenance of heat resistance. dipicolinate synthase catalyzes the formation of dipicolinic acid from dihydroxydipicolinic acid. This family also includes phenyl-acrylic acid decarboxylase (EC:4.1.1.-).


Pssm-ID: 426775 [Multi-domain]  Cd Length: 177  Bit Score: 119.40  E-value: 4.34e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992   17 RNILLGLTASSSIYKSIDLARRLIRMGGNLRVVMTRRSLSLIGVDLVHWATGSK----PFYEMSGETEHIDL---AQWAD 89
Cdd:pfam02441   1 KRILVGITGSSAAIKALRLLEELKKEGAEVRVIMTKAAKKVITPETLAALSENVdedlTWRELDDDILHIELasgARWAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992   90 AMVIAPATLNTMGKIAYGILDELLTLTA-------------TTMMGSSKKVIIVPAMNIRLMSSPQYKNAAGKLEEYGAV 156
Cdd:pfam02441  81 AMVIAPASANTLAKIANGIADNLLTRAAdvalkerrphlenMLTLTAKKPIIIAPAMNTAMYENPATLENLEDLKADGGK 160


                  ....*...
gi 501636992  157 IIPPLIEE 164
Cdd:pfam02441 161 GRMPEPEA 168
PRK07313 PRK07313
phosphopantothenoylcysteine decarboxylase; Validated
 16-160 2.99e-27

phosphopantothenoylcysteine decarboxylase; Validated


Pssm-ID: 235986 [Multi-domain]  Cd Length: 182  Bit Score: 106.57  E-value: 2.99e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  16 GRNILLGLTASSSIYKSIDLARRLIRMGGNLRVVMTRRSLSLIGVDLVHWATGSKPFYEMSGETE-----HIDLAQWADA 90
Cdd:PRK07313   1 MKNILLAVSGSIAAYKAADLTSQLTKRGYQVTVLMTKAATKFITPLTLQVLSKNPVHLDVMDEHDpklmnHIELAKRADL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  91 MVIAPATLNTMGKIAYGILDELLTLTATTMMGSSKKvIIVPAMNIRLMSSPQYKNAAGKLEEYGAVIIPP 160
Cdd:PRK07313  81 FLVAPATANTIAKLAHGIADDLVTSVALALPATTPK-LIAPAMNTKMYENPATQRNLKTLKEDGVQEIEP 149
PLN02496 PLN02496
probable phosphopantothenoylcysteine decarboxylase
 46-161 1.34e-14

probable phosphopantothenoylcysteine decarboxylase


Pssm-ID: 215274  Cd Length: 209  Bit Score: 72.31  E-value: 1.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  46 LRVVMTRRSLSLIG-----------VDLVHWATGSKpfyeMSGETEHIDLAQWADAMVIAPATLNTMGKIAYGILDELLT 114
Cdd:PLN02496  48 VRAVVTKASLHFIDraslpkdvtlyTDEDEWSSWNK----IGDSVLHIELRRWADVMVIAPLSANTLGKIAGGLCDNLLT 123

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 501636992 115 LTATTmMGSSKKVIIVPAMNIRLMSSPQYKNAAGKLEEYGAVIIPPL 161
Cdd:PLN02496 124 CIVRA-WDYSKPLFVAPAMNTFMWNNPFTERHLMSIDELGISLIPPV 169
PRK06732 PRK06732
phosphopantothenate--cysteine ligase; Validated
 194-327 4.72e-11

phosphopantothenate--cysteine ligase; Validated


Pssm-ID: 235856 [Multi-domain]  Cd Length: 229  Bit Score: 62.31  E-value: 4.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 194 ILVTAGPTREYLDPVRVITNPSSGLMGVLIARELACRGARVDLVHGPMTVKPPY--LVKSIHVETTSDMADKIRELTNEt 271
Cdd:PRK06732   3 ILITSGGTTEPIDSVRGITNHSTGQLGKIIAETFLAAGHEVTLVTTKTAVKPEPhpNLSIIEIENVDDLLETLEPLVKD- 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501636992 272 iYDAAVFAAAPADYKP----------ASSSPE----------KISTRDKpYLEVRLEQTPKTIKSIAN-RPRI-LVAF 327
Cdd:PRK06732  82 -HDVLIHSMAVSDYTPvymtdleevsASDNLNefltkqnteaKISSASD-YQVLFLKKTPKVISYVKKwNPNItLVGF 157
PRK06029 PRK06029
UbiX family flavin prenyltransferase;
89-189 5.72e-11

UbiX family flavin prenyltransferase;


Pssm-ID: 235677  Cd Length: 185  Bit Score: 61.07  E-value: 5.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  89 DAMVIAPATLNTMGKIAYGILDELLTLTATTMMGSSKKVIIVP------AMNIRLMSspqyknaagKLEEYGAVIIPPLI 162
Cdd:PRK06029  80 DGMVIAPCSMKTLAKIAHGYSDNLITRAADVMLKERRRLVLCVretplhLGHLRNMT---------KLAEMGAIIMPPVP 150

                         90       100
                 ....*....|....*....|....*..
gi 501636992 163 eedkAKYPPLDDLSHCIDAIVNRGVDL 189
Cdd:PRK06029 151 ----AFYHRPQTLEDMVDQTVGRVLDL 173
PRK09620 PRK09620
hypothetical protein; Provisional
 189-378 8.52e-09

hypothetical protein; Provisional


Pssm-ID: 181997  Cd Length: 229  Bit Score: 55.67  E-value: 8.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 189 LKNRRILVTAGPTREYLDPVRVITNPSSGLMGVLIARELACRGARVDLVHGPMTVKPPYL---VKSIHVETTSDMADKIR 265
Cdd:PRK09620   1 MKGKKVLITSGGCLEKWDQVRGHTNMAKGTIGRIIAEELISKGAHVIYLHGYFAEKPNDInnqLELHPFEGIIDLQDKMK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992 266 ELTNETIYDAAVFAAAPADYkpassSPEKISTRDKPYLE------------VRLEQTPKTIKSIA--NRPRILVAFAAE- 330
Cdd:PRK09620  81 SIITHEKVDAVIMAAAGSDW-----VVDKICDQEGNVLDmngkissdiapiIHFQKAPKVLKQIKqwDPETVLVGFKLEs 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 501636992 331 TCGGEKLVEKTLLKASDYGADLVIGNnvlSSEAGFGKEMLEIVAVAEG 378
Cdd:PRK09620 156 DVNEEELFERAKNRMEEAKASVMIAN---SPHSLYSRGAMHYVIGQDG 200
PRK05920 PRK05920
aromatic acid decarboxylase; Validated
 89-160 1.63e-07

aromatic acid decarboxylase; Validated


Pssm-ID: 180312  Cd Length: 204  Bit Score: 51.39  E-value: 1.63e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501636992  89 DAMVIAPATLNTMGKIAYGILDELLTLTATTMMGSSKKVIIVP------AMNIRLMSspqyknaagKLEEYGAVIIPP 160
Cdd:PRK05920  95 DGMVIAPCSMGTLAAIAHGLSDNLIERAADVVLKERRKLILVPretplsLIHLENML---------KLAEAGAIILPA 163
AfpA COG1036
Archaeal flavoprotein [Energy production and conversion];
89-131 3.86e-05

Archaeal flavoprotein [Energy production and conversion];


Pssm-ID: 440659 [Multi-domain]  Cd Length: 174  Bit Score: 44.04  E-value: 3.86e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 501636992  89 DAMVIAPATLNTMGKIAYGILDELLTlTATTMMGSSK-KVIIVP 131
Cdd:COG1036   81 DTLVIAPATSNTVAKIVLGIADTLVT-NAVAQAGKGRvPSIVFP 123
spoVFB PRK08305
dipicolinate synthase subunit B; Reviewed
 14-129 6.53e-04

dipicolinate synthase subunit B; Reviewed


Pssm-ID: 181370 [Multi-domain]  Cd Length: 196  Bit Score: 40.65  E-value: 6.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501636992  14 LQGRNILLGLTASSSIY-KSIDLARRLIRMGGNLRVVMTRRSLSligVDLVHWATGS--KPFYEMSG--------ETEHI 82
Cdd:PRK08305   3 LKGKRIGFGLTGSHCTYdEVMPEIEKLVDEGAEVTPIVSYTVQT---TDTRFGKAEEwiKKIEEITGnkvintivEAEPL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 501636992  83 DLAQWADAMVIAPATLNTMGKIAYGILDELLTLTATTMMGSSKKVII 129
Cdd:PRK08305  80 GPKKLLDCMVIAPCTGNTMAKLANAITDSPVLMAAKATLRNQRPVVL 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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