|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
19-422 |
1.50e-83 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 265.44 E-value: 1.50e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 19 LVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCG 98
Cdd:PRK10504 14 IVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 99 LSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPL 178
Cdd:PRK10504 94 LSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 179 GLAAIILALRIIPDIRETERRsFDLTGFITTAVAMVSLVTAMErlGDRQPQIWPTL--ALAVLGFGCLTYAIRHFRRATA 256
Cdd:PRK10504 174 GIIGAIATLMLMPNYTMQTRR-FDLSGFLLLAVGMATLTLALD--GSKGLGLSPLAiaGLVAVGVVALLLYLLHARNNNR 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 257 PMVRLDALQVPTFRVTMYGGSLFRSSISAVPFLLPLLFQVGFGMDPFHSGLLVLAVFVGNLTIKPATTPLIRWLGFRRLL 336
Cdd:PRK10504 251 ALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVL 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 337 lingalnVCSLLACALLTPQTPVWAIM-------LILYLGGVFRSIQFTGVSTLAFADVPAAQMSDANTLFSTASQLAVG 409
Cdd:PRK10504 331 -------VATTLGLALVSLLFMLVALLgwyyllpFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMS 403
|
410
....*....|...
gi 501535191 410 LGITLGaiGIRLG 422
Cdd:PRK10504 404 IGVTIA--GLLLG 414
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
23-455 |
3.86e-74 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 238.24 E-value: 3.86e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 23 AFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTE 102
Cdd:cd17503 4 GAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPN 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 103 VHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAA 182
Cdd:cd17503 84 LASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 183 IILalriipdireterrsfdltgfittavamvslvtamerlgdrqpqiwptlalavlgfgcltyairhfrratAPMVRLD 262
Cdd:cd17503 164 LLL----------------------------------------------------------------------APLLDLR 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 263 ALQVPTFRVTMYGGSLFRSSISAVPFLLPLLFQVGFGMDPFHSGLLVLAVFVGNLTIKPATTPLIRWLGFRRLLLINGAL 342
Cdd:cd17503 174 LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLL 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 343 NVCSLLACALLTPQTPVWAIMLILYLGGVFRSIQFTGVSTLAFADVPAAQMSDANTLFSTASQLAVGLGITLGAIGIRLG 422
Cdd:cd17503 254 LALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNR 333
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 501535191 423 EQ--------VGDWLHLSTLPGISFRLSFVFIAVICLVGMI 455
Cdd:cd17503 334 TQfhhsrlseLLAQQVQKQALIIAFNDAFLVSAILLLVGLL 374
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
23-414 |
8.91e-54 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 187.59 E-value: 8.91e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 23 AFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTE 102
Cdd:TIGR00711 10 GTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 103 VHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAA 182
Cdd:TIGR00711 90 LELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 183 IILALRIIPDIRETERRSFDLTGFITTAVAMVSLVTAMERLGDR---QPQIwpTLALAVLGFGCLTYAIRHFRRATAPMV 259
Cdd:TIGR00711 170 VVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERgwfDSNE--ILILSITGLVAIIAFVVWELTDDNPLV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 260 RLDALQVPTFRVTMYGGSLFRSSISAVPFLLPLLFQVGFGMDPFHSGLLVLAVFVGNLTIKPATTPLIRWLGFRRLLLIN 339
Cdd:TIGR00711 248 DLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIG 327
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501535191 340 -GALNVCSLLACALLTPQTPVWAIMLILYLGGVFRSIQFTGVSTLAFADVPAAQMSDANTLFSTASQLAVGLGITL 414
Cdd:TIGR00711 328 lILYAVGFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTAL 403
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
20-460 |
5.10e-45 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 161.19 E-value: 5.10e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 20 VAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGL 99
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 100 STEVHTFVAMRILQGIGGALMVPVGrLAVLRTT-PKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPL 178
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPAS-LALIAATfPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 179 GLAAIILAlriipdireterrsfdltgfittavamvslvtamerlgdrqpqiwptlalavlgfgcltyairhfrratapm 258
Cdd:cd17321 160 GLVALLLA------------------------------------------------------------------------ 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 259 vrldalqvPTFRVTMYGGSLFRSSISAVPFLLPLLFQVGFGMDPFHSGLLVLAVFVGNLTIKPATTPLIRWLGFRRLLLI 338
Cdd:cd17321 168 --------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVA 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 339 NGALNVCSLLACALLTPQTPVWAIMLILYLGGVFRSIQFTGVSTLAFADVPAAQMSDANTLFSTASQLAVGLGITL-GAI 417
Cdd:cd17321 240 GLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALlGAL 319
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 501535191 418 GIRLGEQVGDWLHLSTLPGI-------SFRLSFVFIAVICLVGMIDSLHL 460
Cdd:cd17321 320 LTAGLSANLGDSGVAALLSAaaaafaaGFHLAFLVAAALALLAALLALLL 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-410 |
2.00e-36 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 137.41 E-value: 2.00e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 7 SRDERAFSAPALLVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLA 86
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 87 LAIFTLASVFCGLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYA 166
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 167 SWHWIFFINVPLGLAAIILALRIIPDIRETERRSFdltgfittavamvslvtamerlgdrqpqiwptlalavlgfgclty 246
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARL--------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 247 airhfrrataPMVRLDALQVPTFRVTMYGGSLFRSSISAVPFLLPLLFQVGFGMDPFHSGLLVLAVFVGNLTIKPATTPL 326
Cdd:COG2814 197 ----------RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 327 IRWLGFRRLLLINGALnvcSLLACALLTPQTPVWAIMLILYLGGVFRSIQFTGVSTLAFADVPAAQMSDANTLFSTASQL 406
Cdd:COG2814 267 ADRFGRRRLLLIGLLL---LALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
....
gi 501535191 407 AVGL 410
Cdd:COG2814 344 GGPL 347
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
3-300 |
2.81e-28 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 113.75 E-value: 2.81e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 3 TAISSRDERAFSAPALLVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAI 82
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 83 FTLALAIFTLASVFCGLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFI 162
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 163 TRYASWHWIFFINVPLGLAAIILALRiipdIRETERRSFDLTGFITTAVAMVSLVTAMERLGDRQPQIWPTLALAVLGFG 242
Cdd:COG0477 162 VAALGWRWIFLINAPLGLLALVLRLR----LPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGA 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 501535191 243 CLTYAIRHFRRATAPMVRLDALQVPTFRVTMYGGSLFRSSISAVPFLLPLLFQVGFGM 300
Cdd:COG0477 238 ALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
32-458 |
2.42e-27 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 112.67 E-value: 2.42e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 32 TVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAMRI 111
Cdd:cd17504 13 TMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 112 LQGIGGAlMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAAIILalriip 191
Cdd:cd17504 93 LQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL------ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 192 direterrsfdltgfittaVAMVSLVTAmerlgdRQPQIWPTLALAVLgfgcltyairhfrratapmvrldalqvptFRV 271
Cdd:cd17504 166 -------------------VPLIDLRLL------RRRNVLLANITALL-----------------------------AGF 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 272 TMYGgslfrsSISAVPFLLPLLFQVGFGMDPFHSGLLVLAVFVGNLTIKPATTPLIRWLGFRRLLLIngALNVCSLLACA 351
Cdd:cd17504 192 GMFM------VFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLI--GLVISAVGLLL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 352 LLTPQTPVWAIMLILYLGGVFRSIQFTGVSTLAFADVPAAQMSDANTLFSTASQLAVGLGITLGAIGIRLGEQVGDWLHL 431
Cdd:cd17504 264 LALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITSGGV 343
|
410 420
....*....|....*....|....*..
gi 501535191 432 STLPGisFRLSFVFIAVICLVGMIDSL 458
Cdd:cd17504 344 PTEGA--YVLAFLIGAALALAALLLSL 368
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
25-185 |
9.66e-26 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 107.26 E-value: 9.66e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 25 FMEFLDGTVIATALPDMAKDFGVTAvelNIG--ISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTE 102
Cdd:cd17502 6 FLAALDQTIVATALPTIVAEFGGLS---LVSwvGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 103 VHTFVAMRILQGIGGALMVP-----VGRLAVLRTTPKHLlikAIATLTWpaLVAPIIGPPLGGFITRYASWHWIFFINVP 177
Cdd:cd17502 83 MTMLIVGRAIQGIGGGGLMSlafiiIADLVPPRERGKYQ---GYIGAVF--GIASVAGPLIGGAFTDHLSWRWCFYINLP 157
|
....*...
gi 501535191 178 LGLAAIIL 185
Cdd:cd17502 158 IGGLALAL 165
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
29-414 |
4.06e-25 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 107.89 E-value: 4.06e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 29 LDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVA 108
Cdd:PRK14995 20 IDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 109 MRILQGIGGALMVPvGRLAVLRTTPKHLLIKAIATLTWPAL--VAPIIGPPLGGFITRYASWHWIFFINVPLGLAAIILA 186
Cdd:PRK14995 100 TRALLAIGAAMIVP-ATLAGIRATFTEEKQRNMALGVWAAVgsGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLT 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 187 LRIIPDIRETERRSFDLTGFITTAVAMVSLVTAMERLGDRQPQIWPTLALAVLGFGCLTYAIRHFRRATAPMVRldaLQV 266
Cdd:PRK14995 179 ARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMID---MRL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 267 PTFRVTMYGGSLFRSS-ISAVPFLLPLLFQVGF--GMDPFHSGLLVLAVFVGNLTIKPATTPLIRWLGFRRLLLINGALN 343
Cdd:PRK14995 256 FTHRIILSGVVMAMTAmITLVGFELLMAQELQFvhGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMALS 335
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501535191 344 VCSLLACALLTPQTPVWAIMLILYLGGVFRSIQFTGVSTLAFADVPAAQMSDANTLFSTASQLAVGLGITL 414
Cdd:PRK14995 336 ALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAI 406
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-411 |
5.38e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 102.50 E-value: 5.38e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 19 LVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCG 98
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 99 LSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPL 178
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 179 GLAAIILALRIIPDIRETERRSFDltgfittavamvslvtamerlgdrqpqiwptlalavlgfgcltyairhfRRATAPM 258
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAE-------------------------------------------------EARLSLI 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 259 VRLDALQVPTFRVTMYGGSLFRSSISAVPFLLPlLFQVGFGMDPFHSGLLVLAVFVGNLTIKPATTPLIRWLGFRRLLLI 338
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501535191 339 NGALNVCSLLACALLTPQTPVWAIMLILYLGGVFRSIQFTGVSTLAFADVPAAQMSDANTLFSTASQLAVGLG 411
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
18-190 |
7.49e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 93.78 E-value: 7.49e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 18 LLVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFC 97
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 98 GLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVP 177
Cdd:COG2271 93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGL 172
|
170
....*....|...
gi 501535191 178 LGLAAIILALRII 190
Cdd:COG2271 173 PGLLLALLRFWLL 185
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
18-419 |
7.88e-21 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 93.77 E-value: 7.88e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 18 LLVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFC 97
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 98 GLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVP 177
Cdd:cd17324 82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 178 LGLAAIILALRIIPDIRETERRSFDLTGFITTAVamvslvtamerlgdRQPQIWPTLALAVLGFGCLTyairhfrratap 257
Cdd:cd17324 162 LALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLL--------------RNPRLRLAYLITFLLFGGFF------------ 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 258 mvrldalqvptfrvtmyggslfrssiSAVPFLLPLLFQVGFGMDPFHSGLLVLaVFVGNLTIKPATTPLIRWLGFRRLLL 337
Cdd:cd17324 216 --------------------------ALYTYLAPFLTDVPGFSSSAIIGLLLL-FGVAGVVGSPLAGRLADRGGRRALLI 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 338 INGALnvCSLLACALLTPQTPVWAIMLILYLGGVFRSIQfTGVSTLAFADVPAAQMSdANTLFSTASQLAVGLGITLGAI 417
Cdd:cd17324 269 ALLLL--AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAH-SALQTRVLRLAPEARGL-ASSLYLAAYNLGGALGAALGGL 344
|
..
gi 501535191 418 GI 419
Cdd:cd17324 345 VL 346
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
15-200 |
2.00e-20 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 92.83 E-value: 2.00e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 15 APALLVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLAS 94
Cdd:TIGR00710 5 AFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 95 VFCGLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFI 174
Cdd:TIGR00710 85 LGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAF 164
|
170 180
....*....|....*....|....*.
gi 501535191 175 NVPLGLAAIILALRIIPDIRETERRS 200
Cdd:TIGR00710 165 LSLAGILLSALIFFILPETLPYEARI 190
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
19-204 |
2.22e-19 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 89.55 E-value: 2.22e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 19 LVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCG 98
Cdd:cd17474 3 AVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 99 LSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITrYASWHWIFFINVPL 178
Cdd:cd17474 83 LSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAAL 161
|
170 180
....*....|....*....|....*.
gi 501535191 179 GLAAIILALRIIPDIRETERRSFDLT 204
Cdd:cd17474 162 IPVAFLAILFLLPEPKEKAKSSSATK 187
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
20-455 |
2.82e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 89.17 E-value: 2.82e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 20 VAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGL 99
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 100 STEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLG 179
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 180 LAAIILALRIIPDIRETERRSFDLTGFITTAVAMVSlvtamerlgdRQPQIWPTLALAVLGFgcltyairhfrratapmv 259
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLL----------RDRRLLALFLAIFVLA------------------ 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 260 rldalqvptfrvtmyggslfrSSISAVPFLLPLLFQVGFGMDPFHSGLLVLAVFVGNLTIKPATTPLIRWLGFRRLLLIN 339
Cdd:cd17325 213 ---------------------FAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 340 GALNVcslLACALLTPQTPVWAIMLILYLGGVFRSIQFTGVSTLAFADVPAAQMSDANTLFSTASQLAVGLG-ITLGAIG 418
Cdd:cd17325 272 LLLSA---VALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGpLLGGFLY 348
|
410 420 430
....*....|....*....|....*....|....*..
gi 501535191 419 IRLGeqvgdwlhlstlpgisFRLSFVFIAVICLVGMI 455
Cdd:cd17325 349 DAFG----------------FATPFLAAAALLLLAAV 369
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
37-416 |
3.91e-19 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 88.79 E-value: 3.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 37 ALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAMRILQGIG 116
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 117 GALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAAIILALRIIPDIRET 196
Cdd:cd17320 101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 197 ERRSFDLTGFITTAVAMVslvtamerlgdRQPQIWPTLALAVLGFgcltyairhfrratapmvrldalqvptfrvtmygG 276
Cdd:cd17320 181 EKRKPLLSSLLRAYKRVL-----------KNRRFLGYALALGLSF----------------------------------A 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 277 SLFrSSISAVPFllplLFQVGFGMDPFHSGLLVLAVFVGNLTIKPATTPLIRWLGFRRLLLINGALNVCSLLACALLTPQ 356
Cdd:cd17320 216 GLF-AYLAAAPF----IYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALL 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501535191 357 TPVWAIMLILYLGGVFRSIQFTGVSTLAFADVPAAQM-SDANTLFSTASQLAVGLGITLGA 416
Cdd:cd17320 291 GGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVaGTASALLGFLQFLIGALAGALVG 351
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
31-191 |
4.03e-19 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 88.79 E-value: 4.03e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 31 GTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAMR 110
Cdd:cd17323 15 SSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 111 ILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAAIILALRII 190
Cdd:cd17323 95 FLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFL 174
|
.
gi 501535191 191 P 191
Cdd:cd17323 175 P 175
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
18-187 |
1.54e-18 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 86.86 E-value: 1.54e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 18 LLVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFC 97
Cdd:cd17319 6 PLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 98 GLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFInvp 177
Cdd:cd17319 86 GFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII--- 162
|
170
....*....|
gi 501535191 178 LGLAAIILAL 187
Cdd:cd17319 163 EGLLGLLLAV 172
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
37-199 |
6.77e-18 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 84.97 E-value: 6.77e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 37 ALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAMRILQGIG 116
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 117 GALMVPVGRlAVLRTT-PKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAAIILALRIIPDIRE 195
Cdd:PRK11102 93 AAAASVVIN-ALMRDMfPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPETLP 171
|
....
gi 501535191 196 TERR 199
Cdd:PRK11102 172 KERR 175
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
56-192 |
2.27e-16 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 75.76 E-value: 2.27e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 56 ISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKH 135
Cdd:TIGR00880 4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 501535191 136 LLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAAIILALRIIPD 192
Cdd:TIGR00880 84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
23-196 |
1.14e-14 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 75.45 E-value: 1.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 23 AFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTE 102
Cdd:TIGR00893 2 VTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 103 VHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAA 182
Cdd:TIGR00893 82 YVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGIIW 161
|
170
....*....|....
gi 501535191 183 IILALRIIPDIRET 196
Cdd:TIGR00893 162 GVLWLKFIPDPPQK 175
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
36-196 |
1.70e-14 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 75.06 E-value: 1.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 36 TALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAMRILQGI 115
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 116 G-GALMVPVgrLAVLRTT-PKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAAIILALRIIPDI 193
Cdd:PRK10473 104 GaGCCYVVA--FAILRDTlDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKET 181
|
...
gi 501535191 194 RET 196
Cdd:PRK10473 182 RPA 184
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-455 |
5.89e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 73.38 E-value: 5.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 18 LLVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFC 97
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 98 GLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVP 177
Cdd:COG2223 88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 178 LGLAAIILALRIIPDIRETERRSfdltgfittavAMVSLVTAMERLgdRQPQIWPTLALAVLGFGCltyairhfrratap 257
Cdd:COG2223 168 LLLVVAVLAWLFLRDPPAGAAAA-----------AKASLRDQLEAL--RDPRFWLLSLLYFGTFGS-------------- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 258 mvrldalqvptfrvtMYGGSLFrssisavpflLPLLFQVGFGMDPFHSGLLVLAVFVGNLTIKPATTPLIRWLGFRRLLL 337
Cdd:COG2223 221 ---------------FIGFSSW----------LPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLL 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 338 INGALNVCSLLacALLTPQTPVWAIMLILYLGGVFRSIQFTGVSTLAFADVPAAQMSdantlfstasqLAVGLGITLGAI 417
Cdd:COG2223 276 IVFALMALGLL--LLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAG-----------AVYGLVGAAGGL 342
|
410 420 430
....*....|....*....|....*....|....*...
gi 501535191 418 GIRLGEQVGDWLHLSTLpgiSFRLSFVFIAVICLVGMI 455
Cdd:COG2223 343 GGFLGPLLFGALLDATG---SYTAAFLVFAVLALVALV 377
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-417 |
2.66e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 71.30 E-value: 2.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 20 VAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGL 99
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 100 STEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRY--ASWHWIFFINVP 177
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 178 LGLAAIILALRIIPDIRETERRSFDLTGFITTAVAMVSLvtamerlgdrqpqiwptlalavlgfgcltyairhfrratap 257
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRV----------------------------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 258 mvrldaLQVPTFRVTMYGGSLFRSSISAVPFLLPLLFQVGFGMDPFHSGLLVLAVFVGNLTIKPATTPLIRWLGFRRLLL 337
Cdd:cd06174 200 ------LKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 338 INGAlnVCSLLACALLTPQTPVWAIMLILYLGGVFRSIQFTGVSTLAFADVPAAQMSDANTLFSTASQLAVGLGITLGAI 417
Cdd:cd06174 274 LIGL--LLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGF 351
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
20-194 |
1.09e-12 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 69.21 E-value: 1.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 20 VAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGL 99
Cdd:cd17476 3 ISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 100 STEVHTFVAMRILQGIGGALMVPVGrLAVLRTTPKHLLIKAIAtLTWPALVAP---IIGPPLGGFITRYASWHWIFFINV 176
Cdd:cd17476 83 SPNFIFFIICRALQGLGPAFLLPNA-MALLGRTYPPGPRKNIV-FSLFGATAPlgfALGGVFGGLFAQLAWWPWIFWFLA 160
|
170
....*....|....*....
gi 501535191 177 PL-GLAAIILALRIIPDIR 194
Cdd:cd17476 161 ILaAIVAVAAIFWTSPSFI 179
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
43-203 |
2.76e-12 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 68.04 E-value: 2.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 43 KDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAMRILQGIGGALMVP 122
Cdd:PRK15402 41 EDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 123 VGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAAIILALRIIPDIRETERRSFD 202
Cdd:PRK15402 121 VGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPETAGRVGEKLS 200
|
.
gi 501535191 203 L 203
Cdd:PRK15402 201 L 201
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
18-419 |
1.25e-11 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 66.50 E-value: 1.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 18 LLVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIgISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFC 97
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNSTWI-STAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 98 GLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLiKAIATLTWPALVAPIIGPPLGGFITR--YASWHWIFFIN 175
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRG-LVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIFYIN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 176 VPL-GLAAIILALRIIPDIRETER--------RSFDLTGFITTAVAMVSLVTAMERLGDRQP-----QIWPTLALAVLGF 241
Cdd:cd06179 159 AIFnALALILLFFFYHPPPRPQLHgsstrqklKRLDWVGLFLLIAGLVLFLLGLSWGGNPYPwssahVIAPLVIGGVLLI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 242 GCLTYAIRHFRRATAPMVRLdalqvptFRVTMYGGSLFRSSISAVPF-----LLPLLFQVGFGMDPFHSGLLVLAVFVGN 316
Cdd:cd06179 239 AFGLYEWKGTKDGLLPPRLL-------FRGRNFALILIVAFVEGMIFyslniFWPQQISLLFTTDPLKAGLYQLPFGLGT 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 317 LTIKPATTPLIRWLGFRRLLLINGAlnVCSLLACALLTPQTPVWAIMLILYLggVFRSIQFTGVSTLAFAdvpAAQMSDA 396
Cdd:cd06179 312 LFGAILAGLLLTKIKHIKWQLVAGF--VLFTAFLALLALITPDNKALAIAFS--VLAGIGIGGPLVLAIV---IVQLSVP 384
|
410 420
....*....|....*....|...
gi 501535191 397 NTLFSTASQLAVGLGITLGAIGI 419
Cdd:cd06179 385 PEDIGTASGLLGSARALGGAVGT 407
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
19-248 |
1.01e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.41 E-value: 1.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 19 LVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCG 98
Cdd:cd17328 3 VLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 99 LSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYA-SWHWIFFINVP 177
Cdd:cd17328 83 FAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGV 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501535191 178 LGLAAIILALRIIPDIR--ETERRSFDLTGFITTAVAMVSLVTAmerlgdrqpqiwPTLALAVLGFGCLTYAI 248
Cdd:cd17328 163 LGVLLAILLLLFVREPPrgAAEGGVMAKSTATSFLADLKALAKN------------PSFILSTLGFTAVSFVT 223
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
32-199 |
1.39e-10 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 63.00 E-value: 1.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 32 TVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAMRI 111
Cdd:PRK11652 25 TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 112 LQGIGGAlmvpVGRlAVLRTTPKHL-----LIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAAIILA 186
Cdd:PRK11652 105 IQGLGTG----VGG-VMARTLPRDLyegtqLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSM 179
|
170
....*....|...
gi 501535191 187 LRIIPDIRETERR 199
Cdd:PRK11652 180 ARWMPETRPADAR 192
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-190 |
1.33e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 59.54 E-value: 1.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 17 ALLVAGAFFMEFLDGTVIATALPDMAKDF--GVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLAS 94
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 95 VFCGLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATL----TWPALVAPIIGPPLGGFITRYASWHW 170
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLqsgwALGALLAALVASLLIPLLSGDWGWRI 160
|
170 180
....*....|....*....|
gi 501535191 171 IFFINVPLGLAAIILALRII 190
Cdd:cd17316 161 LFLIGALPALLALLLRRRTL 180
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
36-425 |
1.96e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.14 E-value: 1.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 36 TALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAMRILQGI 115
Cdd:cd17489 17 PVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 116 GGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAAIILALRIIPDIRE 195
Cdd:cd17489 97 GWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 196 TERRSFDLTGFITTAVAMVSLVTAMerlgdrqpqiwpTLALAVLGFGCLTyairhfrratapmvrldalqvpTFrVTMYG 275
Cdd:cd17489 177 AAEEAEAGTRAFRRLVEKKVLPPAL------------ILFLASIAYGAIS----------------------TF-LPLYA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 276 GSLFRSSISavpfllplLFQVGFGMdpfhsGLLVLAVFVGNLtikpattplIRWLGFRRLLLINGALNVCSLLacaLLTP 355
Cdd:cd17489 222 AERGISNAG--------LFFTVYAI-----ALLLSRPFSGKL---------SDRKGPKTVIIPGLLLLALGLL---LLSF 276
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501535191 356 QTPVWAIMLILYLGGVFRSIQFTGVSTLAFADVPAAQMSDANTLFSTASQLAVGLG-ITLGAIGIRLGEQV 425
Cdd:cd17489 277 AGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGgLLLGLVAELFGYRA 347
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
35-197 |
2.23e-09 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 58.93 E-value: 2.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 35 ATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAMRILQG 114
Cdd:TIGR00881 15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 115 IGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGF-ITRYASWHWIFFINVPLGLAAIILALRIIPDI 193
Cdd:TIGR00881 95 IFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAIIVSLICFLLLRDS 174
|
....
gi 501535191 194 RETE 197
Cdd:TIGR00881 175 PQSC 178
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
5-451 |
2.69e-09 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 59.33 E-value: 2.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 5 ISSRDERAFSAPALlvagAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFT 84
Cdd:PRK03893 14 LNRAQWKAFSAAWL----GYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 85 LALAIFTLASVFCGLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATL--------TWPALVAPIIGP 156
Cdd:PRK03893 90 ISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLisgfsigaVVAAQVYSLVVP 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 157 PLGgfitryasWHWIFFInvplGLAAIILAL---RIIP---DIRETERRSFDLTGFIT--------------TAVAMVSL 216
Cdd:PRK03893 170 VWG--------WRALFFI----GILPIIFALwlrKNLPeaeDWKEKHAGKAPVRTMVDilyrgehriinillTLAAAAAL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 217 VTAMerLGDRQPqIWPTLALAVLGFGCLTYAIRHFRRATAPMvrLDALQVPTFRVTMYGGslfrsSISAvpfLLPLLFQV 296
Cdd:PRK03893 238 WFCF--AGNLQN-AAIVAVLGLLCAAIFISFMVQSSGKRWPT--GVMLMVVVLFAFLYSW-----PIQA---LLPTYLKT 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 297 GFGMDPFHSGLLVLAVFVGNLTIKPATTPLIRWLGFRRLLlingalnVCSLLACALLTpqTPVWAI--MLILYLGGVFRS 374
Cdd:PRK03893 305 DLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAY-------VCSLLISQLLI--IPVFAIggANVWVLGLLLFF 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 375 IQFT--GVSTLafadVPAAQMSDANTlfstaSQLAVGLGITL------GAIGIRLGEQVGDWLHL-STLPGISFRLSFVF 445
Cdd:PRK03893 376 QQMLgqGISGL----LPKLIGGYFDT-----EQRAAGLGFTYnvgalgGALAPILGALIAQRLDLgTALASLSFSLTFVV 446
|
....*.
gi 501535191 446 IAVICL 451
Cdd:PRK03893 447 ILLIGL 452
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
18-190 |
2.73e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 58.91 E-value: 2.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 18 LLVAGAFFMEFLDG---TVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLAS 94
Cdd:TIGR00895 17 RAIILSFLIMLMDGydlAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 95 VFCGLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFI 174
Cdd:TIGR00895 97 LLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV 176
|
170
....*....|....*.
gi 501535191 175 NvplGLAAIILALRII 190
Cdd:TIGR00895 177 G---GIAPLLLLLLLM 189
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-455 |
3.32e-09 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 58.73 E-value: 3.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 1 MNTAISSRDERAFSAPALLVAGAFFMEFLDG---TVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRF 77
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRpaiTSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 78 GARAIFTLALAIFTLASVFCGLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHL-LIKAIATLTWPALVApiIGP 156
Cdd:COG2807 81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVgLMTGLYTAAMGLGAA--LAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 157 PLGGFITRYASWHWIFFINVPLGLAAIILALRIIPDIRETERRSfdltgfiTTAVAMVSLVtamerlgdRQPQIWpTLAL 236
Cdd:COG2807 159 GLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAA-------PAAASLRSLW--------RSPLAW-LLTL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 237 AVLGFGCLTYAIrhfrratapmvrldalqvptfrvtmyggslfrssisaVPFLLPLLfqVGFGMDPFHSGLLVLAVFVGN 316
Cdd:COG2807 223 FFGLQSLLYYAV-------------------------------------VAWLPPIL--RDAGLSAATAGLLLSLFQLAG 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 317 LTIKPATTPLIRWLGFRRLLLINGALNVCSLLACALLTPQTPVWAIMLILYLGGVfrsiqftGVSTLAFAdVPAAQMSDA 396
Cdd:COG2807 264 IPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQG-------GLFPLALT-LIGLRARTP 335
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 501535191 397 NTLfSTASQLAVGLGITLGAIGIRLGEQVGDWLHlstlpgiSFRLSFVFIAVICLVGMI 455
Cdd:COG2807 336 AEA-AALSGMAQSVGYLLAALGPLLVGALHDATG-------SWTAALLLLAALAVLMLV 386
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
6-190 |
3.86e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 58.36 E-value: 3.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 6 SSRDERAFSAPALLVAGAFFMEFLDGTVIATALPDMAKD-FGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFT 84
Cdd:cd17325 190 SGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAElGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLIL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 85 LALAIFTLASVFCGLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITR 164
Cdd:cd17325 270 IGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD 349
|
170 180
....*....|....*....|....*.
gi 501535191 165 YASWHWIFFINVPLGLAAIILALRII 190
Cdd:cd17325 350 AFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
25-205 |
6.01e-09 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 57.91 E-value: 6.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 25 FMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVH 104
Cdd:PRK15403 26 FAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMT 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 105 TFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAAII 184
Cdd:PRK15403 106 QFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFV 185
|
170 180
....*....|....*....|.
gi 501535191 185 LALRIIPDIRETERRSFDLTG 205
Cdd:PRK15403 186 GLLLAMPETVKRGAVPFSAKS 206
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
20-186 |
7.37e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 57.21 E-value: 7.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 20 VAGAFFMEFLDG---TVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVF 96
Cdd:cd17365 1 LALCFLIIVLDGfdlAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 97 CGLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINV 176
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
170
....*....|
gi 501535191 177 PLGLAAIILA 186
Cdd:cd17365 161 VPPLILLPLL 170
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
30-116 |
8.14e-09 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 57.19 E-value: 8.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 30 DGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAM 109
Cdd:cd17359 16 DTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIA 95
|
....*..
gi 501535191 110 RILQGIG 116
Cdd:cd17359 96 RIIGGLA 102
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
25-194 |
4.62e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 54.89 E-value: 4.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 25 FMEFLDGTVIATALPDMAKDFGV-TAVELNIGI--SAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLST 101
Cdd:cd17330 6 FLDALGFGIVFPVLPFYVREFNKlGASGYYVGLlqSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 102 EVHTFVAMRILQGIGGALmVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLA 181
Cdd:cd17330 86 NLWLLFLARFLDGLTGGN-VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALL 164
|
170
....*....|...
gi 501535191 182 AIILALRIIPDIR 194
Cdd:cd17330 165 NLVLVLFFLPPLR 177
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
31-403 |
6.40e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 54.50 E-value: 6.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 31 GTVIATALPDMAKDF-GVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAM 109
Cdd:cd17473 15 GAAIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLAS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 110 RILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYaSWHWIFFINVpLGLAAIILALRI 189
Cdd:cd17473 95 RALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVYL-LALPVLILVLLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 190 IPDIRETERRSfdltgfittavamvSLVTAMERLGDRQPQIWPTLALAVLGFgcltyairhfrratapmvrldalqvptf 269
Cdd:cd17473 173 LPEPARKSKSA--------------ASPGAATAAALPWKRVLPIYFLAFLAM---------------------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 270 rVTMYggslfrssisAVPFLLPLLFQVGFGMDPFHSGLLVLAVFVGNLTIKPATTPLIRWLGFRRLLLINGALNVCSLLA 349
Cdd:cd17473 211 -LLFY----------VIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLL 279
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 501535191 350 CALltpQTPVWAIMLILYLGGVFRSIQFTGVSTLAFADVPAAQMSDANTLFSTA 403
Cdd:cd17473 280 LAL---ASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSA 330
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
6-185 |
8.20e-08 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 54.67 E-value: 8.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 6 SSRDERAFSAPALLVAGAFFMefLDGTviATALPDMAKDFGVTAvelNIGISAYLITL--AVLIPASGWIADRFGARAiF 83
Cdd:pfam06609 39 SPRIIASFAAFSLNVCATYFV--LQAS--ASALPNILQDIGQSE---NQGLFSTLWTMgqAVSILMMGRLTDRFGRRP-F 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 84 TLALAIFTLASVFCGLS-TEVHTFVAMRILQGIG----GALMVPVGRLAVLRTTPKHLLIKAIatltwPALVAPIIGPPL 158
Cdd:pfam06609 111 VIATHIIGLVGAIVGCTaNKFNTLLAAMTLLGVAagpaGASPLFIGELMSNKTKFLGLLIVSA-----PTIAMNGAGPYF 185
|
170 180
....*....|....*....|....*..
gi 501535191 159 GGFITRYASWHWIFFINVPLGLAAIIL 185
Cdd:pfam06609 186 GQRLAIQGNWRWIFYIYIIMSAIAVLL 212
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
33-194 |
8.97e-08 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 53.94 E-value: 8.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 33 VIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAMRIL 112
Cdd:PRK10091 21 GIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 113 QGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAAIILALRIIPD 192
Cdd:PRK10091 101 SGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIAVFNIAVLASIYFWVPD 180
|
..
gi 501535191 193 IR 194
Cdd:PRK10091 181 IR 182
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
18-195 |
1.74e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 52.95 E-value: 1.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 18 LLVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLA--LAIFTLASV 95
Cdd:COG2271 184 LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAigLLLAALALL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 96 FCGLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFIN 175
Cdd:COG2271 264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLL 343
|
170 180
....*....|....*....|
gi 501535191 176 VPLGLAAIILALRIIPDIRE 195
Cdd:COG2271 344 AALALLAALLALLLLRETRK 363
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
36-417 |
4.17e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.85 E-value: 4.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 36 TALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAI-----FTLALAIFTLASVFCGLSTEVHTFVAMR 110
Cdd:cd06173 20 VALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 111 ILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAAIILALRII 190
Cdd:cd06173 100 FLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 191 PDIRETERRSFDLTGFITTAvamvslvtamerlgdrqpqiwptlalavlgfgcltyAIRHFRRAtapmvrldalqvPTFR 270
Cdd:cd06173 180 RPPPAAPGESSSLLLRDLRE------------------------------------GLRYLRRS------------PLLR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 271 VTMYGGSLFRSSISAVPFLLPLLFQVGFGMDPFHSGLLVLAVFVGNLTIKPATTPLIRWLGFRRLLLINGALNVCSLLAC 350
Cdd:cd06173 212 LLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVL 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501535191 351 ALLtpqTPVWAIMLILYLGGVFRSIQFTGVSTLAFADVPAAQMSDANTLFSTASQLAVGLGITLGAI 417
Cdd:cd06173 292 GLS---PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGL 355
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
11-390 |
1.34e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 50.24 E-value: 1.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 11 RAFSAPALLVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIF 90
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 91 TLASVFCGLSTEVHTFVAMRILQGIGGAL----MVPVGRLAVLRTTPKHL----LIKAIATLTWPALVAPIIGPPLGgfi 162
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLldvaANPYVAALGPETAASRLnllhAFFSLGALLGPLLGGLLILLGLS--- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 163 tryASWHWIFFIN-VPLGLAAIILALRIIPDIRETERRSFDLTGfittavamvslvtamerlgdRQPQIWPTLALAVLGF 241
Cdd:COG0738 161 ---LSWHLPYLILaVLLLLLALLFLRSKLPEIEEEEEEAAGSAA--------------------SLKSLLKNPRLLLGGL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 242 GCLTYAirhfrratapmvrldALQVptfrvtmyggslfrssisAVPFLLPLLFQVGFGMDPFHSGLLVLAVFVGNLTIKP 321
Cdd:COG0738 218 AIFLYV---------------GAEG------------------AIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRF 264
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501535191 322 ATTPLIRWLGFRRLLLINGALNVCsLLACALLTPQtpVWAIMLILYLGGVFRSIQFTGVSTLAFADVPA 390
Cdd:COG0738 265 LGGFLLKRFGPVRLLRLSALLAAV-GLLLALLAPG--PWLALIGLALVGLGLSLMFPTIFSLALDGLGK 330
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
11-189 |
2.93e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 49.11 E-value: 2.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 11 RAFSAPALLV--AGAFFMEFLDGTVIaTALPDMAKD-FGVTAVELNIGISAYLITLAVLIPASG-WIADRFGARAIFTLA 86
Cdd:cd17474 193 KALRGRGLLTflVSAFLYFFLYFAFL-TYLPFLLELlYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIG 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 87 LAIFTLASVFCGLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYA 166
Cdd:cd17474 272 LLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIF 351
|
170 180
....*....|....*....|...
gi 501535191 167 SWHWIFFINVPLGLAAIILALRI 189
Cdd:cd17474 352 GLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
45-192 |
4.27e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 48.75 E-value: 4.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 45 FGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAMRILQGIGGalMVPVG 124
Cdd:cd17472 27 PGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGA--ISSVV 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501535191 125 RLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAAIILALRIIPD 192
Cdd:cd17472 105 MALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPD 172
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
34-190 |
5.64e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 48.42 E-value: 5.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 34 IATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAMRILQ 113
Cdd:cd17312 22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLN 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501535191 114 GI-GGALMVPVGRLAVLRTTPKHLLIKaIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLA-AIILALRII 190
Cdd:cd17312 102 GLfQSMGWPPCVKLLGNWFSKKERGTV-YGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVvAIILFFFLR 179
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
38-460 |
8.04e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 47.99 E-value: 8.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 38 LPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFT-LASVFCGLSTEVHTFVAMRILQGIG 116
Cdd:cd17490 19 LSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTvLASLIMILFPSPWGLLIARFLSGIA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 117 GALMVPvgrLAVLRTT--PKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAAIILALRIIPDIR 194
Cdd:cd17490 99 AATWVS---FTVLYASyfPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 195 ETERRSFDLTGFITTAvamvslvtamerlgdRQPQIWPTLALAVLgfgcltyairhfrratapmvrldaLQVPTFRVTMY 274
Cdd:cd17490 176 EKKPVLTELKELLSVL---------------KDKKLLFFSLLAIL------------------------QQMITFSTTFG 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 275 GGSLFRSSISAVPFLLPLlfqvgfgmdpfhsgLLVLAVFVGNLTIKPATTPLIRWLGFRRLLLINGALnvcsLLACALLT 354
Cdd:cd17490 217 FTPLIAKQLGASSFQLGL--------------LSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLL----LGAYCFLI 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 355 PQTP-VWAIMLILYLGGVFRSIQFTGVSTLAFADVPAAQMSDANTLFstasQLAVGLGITLGAIgirLGEQVGDWLHLST 433
Cdd:cd17490 279 PFAPnLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFF----QAIYALGMFLGPV---LVGIISEAFGLQT 351
|
410 420
....*....|....*....|....*..
gi 501535191 434 lpgisfrlSFVFIAVICLVGMIDSLHL 460
Cdd:cd17490 352 --------GFFVIGVIALLAAILSLAY 370
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
18-199 |
1.95e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.84 E-value: 1.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 18 LLVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFC 97
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 98 GLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYaSWHWIFFINVP 177
Cdd:cd17329 83 GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAV 161
|
170 180
....*....|....*....|..
gi 501535191 178 LGLAAIILALRIIPDIRETERR 199
Cdd:cd17329 162 LFLLAALVLLFLLPETRPKRRA 183
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
18-189 |
2.09e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.77 E-value: 2.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 18 LLVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFC 97
Cdd:COG0738 214 LGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLA 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 98 GLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHlLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVP 177
Cdd:COG0738 294 LLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLV 372
|
170
....*....|..
gi 501535191 178 LGLAAIILALRI 189
Cdd:COG0738 373 CYLLILLLALAL 384
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
17-187 |
9.29e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.51 E-value: 9.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 17 ALLVAGAFFMEFLDGTVIATALPDMAKDFGVTavelNIGI--SAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLAS 94
Cdd:cd17489 196 VLPPALILFLASIAYGAISTFLPLYAAERGIS----NAGLffTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGL 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 95 VFCGLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFI 174
Cdd:cd17489 272 LLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLL 351
|
170
....*....|...
gi 501535191 175 NVPLGLAAIILAL 187
Cdd:cd17489 352 AAVVVLLALVLYI 364
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
33-116 |
9.38e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 44.49 E-value: 9.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 33 VIATALPDMAKDFGV--TAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAMR 110
Cdd:cd17315 15 VINGALLYIAKDLGFglSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGR 94
|
....*.
gi 501535191 111 ILQGIG 116
Cdd:cd17315 95 FLLGLG 100
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
26-119 |
1.46e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 44.18 E-value: 1.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 26 MEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHT 105
Cdd:PRK11551 26 LEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS 105
|
90
....*....|....*.
gi 501535191 106 FVAMRILQGI--GGAL 119
Cdd:PRK11551 106 LLVARLLTGVglGGAL 121
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
30-123 |
1.80e-04 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 43.80 E-value: 1.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 30 DGTVIATALPDMAKDFGV---TAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTF 106
Cdd:cd17360 12 DTGVISGALLYIKDDLGEvvlSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVL 91
|
90 100
....*....|....*....|
gi 501535191 107 VAMRILQGIG---GALMVPV 123
Cdd:cd17360 92 IVGRVLVGLGvgiASMTVPL 111
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
70-411 |
3.54e-04 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 42.81 E-value: 3.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 70 SGWIADRFGARAIFTLALAIFTLASVFCGLST-----EVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATL 144
Cdd:pfam05977 65 AGALADNFDRRKIMLAGQLLLALVSTLLTLLAglgllSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALN 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 145 TWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAAIILALRIIPDIRETerrsfdltgfittavamvslVTAMERLg 224
Cdd:pfam05977 145 SVGYNIARSVGPALGGVLLAAFGPAFTFALNALSYFAVIAALWRWKRAAPAS--------------------PLPRERI- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 225 drqpqiwptlalavlgFGCLTYAIRhFRRATAPMvrldalqvptfRVTMYGGSLFRSSISAVPFLLPLLFQVGFGMDPFH 304
Cdd:pfam05977 204 ----------------FGAVRAGLR-FTAMSREL-----------RSVLVRAFAFGLSASAVWALLPLVARDLLDGDAIF 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 305 SGLLVLAVFVGNLTIKPATTPLIRWLGFRRLLLINGALNVCSLLACALLtpqTPVWAIMLILYLGGVFRSIQFTGVSTLA 384
Cdd:pfam05977 256 YGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALA---PNLWLAIPVLLLGGAAWITALTTLNVAV 332
|
330 340
....*....|....*....|....*..
gi 501535191 385 FADVPAAQMSDANTLFSTASQLAVGLG 411
Cdd:pfam05977 333 QLSVPRWVRGRALAVYQTVFFGGMAAG 359
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
54-124 |
3.69e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 42.57 E-value: 3.69e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501535191 54 IGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAMRILQGIGGALMVPVG 124
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVG 99
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
16-187 |
5.16e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 42.26 E-value: 5.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 16 PALLVAGAFFMEFLDGTVIATA---LPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTL 92
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFgvfIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 93 ASVFCGLSTEVHTF-VAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWI 171
Cdd:cd17355 81 GLVLLALATSLWQLyLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170
....*....|....*.
gi 501535191 172 FFINVPLGLAAIILAL 187
Cdd:cd17355 161 LLVLALLALLVLVPVL 176
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
18-188 |
6.10e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.79 E-value: 6.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 18 LLVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAY-LITLAVLIPASGWIADRFGARAIFTLALAIFTLASVF 96
Cdd:cd17330 178 RLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVgIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 97 CGLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINV 176
Cdd:cd17330 258 LPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAA 337
|
170
....*....|..
gi 501535191 177 PLGLAAIILALR 188
Cdd:cd17330 338 GLLLIALFLLSL 349
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
17-189 |
7.05e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.83 E-value: 7.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 17 ALLVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVF 96
Cdd:cd06173 211 RLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLV 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 97 CGLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINV 176
Cdd:cd06173 291 LGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAG 370
|
170
....*....|...
gi 501535191 177 PLGLAAIILALRI 189
Cdd:cd06173 371 ALLLLAALLLLLL 383
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
41-204 |
1.25e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 41.03 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 41 MAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAMRILQGIGGalm 120
Cdd:PRK11043 32 IQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGV--- 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 121 vpvgrlavlrttpkhllikAIATLTWPALV----------------------APIIGPPLGGFITRYASWHWIFFINVPL 178
Cdd:PRK11043 109 -------------------CSAAVIWQALVidrypaqkanrvfatimplvalSPALAPLLGAWLLNHFGWQAIFATLFAI 169
|
170 180
....*....|....*....|....*.
gi 501535191 179 GLAAIILALRIIPDIRETERRSFDLT 204
Cdd:PRK11043 170 TLLLILPTLRLKPSKKARKQSQDALT 195
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
32-174 |
1.25e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 41.10 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 32 TVIATALPDMAKDFGVTAVEL-----NIGISAYLITLAVLIPASGWIADRFG-----ARAIFTLALAIFTLASVfcglsT 101
Cdd:cd17391 13 SLIAPFLPLYIEQLGVTSGGLvelwsGLAFSSTFLVSAIFSPIWGRLADRYGrkpmlLRASLGMAIVIGLMAFV-----T 87
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501535191 102 EVHTFVAMRILQGIGGALmVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFI 174
Cdd:cd17391 88 NVWQLLILRLLQGVFSGY-VPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFI 159
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
23-191 |
1.43e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 40.62 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 23 AFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGL--S 100
Cdd:cd17380 7 ATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLlaY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 101 TEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLT----WPALVAPIIGPPLggfiTRYASWHWIFFINV 176
Cdd:cd17380 87 SSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTagsyLGTLLGGLIGPLL----LEYYGWPSVFYFFG 162
|
170
....*....|....*
gi 501535191 177 PLGLAAIILALRIIP 191
Cdd:cd17380 163 LLGLLWALVWLIYLP 177
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
33-201 |
1.91e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.23 E-value: 1.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 33 VIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTEVHTFVAMRIL 112
Cdd:cd17477 14 LLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 113 QGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFI-TRYASWHWIFFINVPLGLAAIILALRIIP 191
Cdd:cd17477 94 MGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVgTAGALPFLIAAVLLLLALVPLLLTRRAAP 173
|
170
....*....|
gi 501535191 192 DIRETERRSF 201
Cdd:cd17477 174 EIEEAESISL 183
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
21-116 |
3.54e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 39.59 E-value: 3.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 21 AGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLS 100
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA 84
|
90
....*....|....*.
gi 501535191 101 TEVHTFVAMRILQGIG 116
Cdd:cd17371 85 QNYWQLLILRALAGLG 100
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
23-118 |
4.19e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.16 E-value: 4.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 23 AFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLASVFCGLSTE 102
Cdd:cd17341 7 SFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVS 86
|
90
....*....|....*..
gi 501535191 103 VHT-FVAMRILQGIGGA 118
Cdd:cd17341 87 SYWgLLVLGFLLGFAGA 103
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-187 |
5.84e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.95 E-value: 5.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 18 LLVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADR-FGARAIFTLALAIFTLASVF 96
Cdd:cd06174 207 LLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLAL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 97 CGLSTEVHTFVAMRILQGIGGALMVPVGRLAVLRTTPKHLLIKAIATLTWPALVAPIIGPPLGGFIT-RYASWHWIFFIN 175
Cdd:cd06174 287 LLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVL 366
|
170
....*....|..
gi 501535191 176 VPLGLAAIILAL 187
Cdd:cd06174 367 AVLLLLAAILLL 378
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
59-191 |
6.55e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 6.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 59 YLITLavlIPaSGWIADRFGARAIFTLALAIFTLASVFCGLSTEVH--TFVAMRILQGIGGALMVPVGRLAVLRTTPKHL 136
Cdd:cd17318 69 YILTQ---IP-GGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGygALIVLRILQGLAQGVTFPAMHALWAKWAPPLE 144
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 501535191 137 LIKAIATLTWPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAAIILALRIIP 191
Cdd:cd17318 145 RSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVL 199
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|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
68-200 |
7.54e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 38.35 E-value: 7.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 68 PASGWIADRFGARAIFTLALaiftLASVFCGLSTEVHTFVAMRILQGIGGALM--VPVGRLAVLRTTPKHLLIKAIATLT 145
Cdd:cd17331 53 PLFGRFGDLFGPRAALVLSF----LSSALSYLLLAFASSVPMLFLSRLPSVFMhaMQAAQMVVTDLTDPGERAAALGRLG 128
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 501535191 146 WPALVAPIIGPPLGGFITRYASWHWIFFINVPLGLAAIILALRIIPDIRETERRS 200
Cdd:cd17331 129 LSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREK 183
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|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
15-186 |
8.40e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 38.39 E-value: 8.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 15 APALLVAGAFFMEFLDGTVIATALPDMAKDFGVTAVELNIGISAYLITLAVLIPASGWIADRFGARAIFTLALAIFTLAS 94
Cdd:cd17393 200 LLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 95 VFCGLSTEVHTFVAMRILQGIGGALMVPV-----GRLAVLRTTpkhlliKAIATLTWPALVAPIIGPPLGGFITRYASWH 169
Cdd:cd17393 280 LLALLAPSVWVALAGFALMGLGLSVVVPLafsaaGALPGLAAG------IAVARVATLGYLGFLVGPPLIGFLADATGLR 353
|
170
....*....|....*..
gi 501535191 170 WIFFINVPLGLAAIILA 186
Cdd:cd17393 354 TAFLVVALLALLVALLA 370
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|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
258-455 |
8.43e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.42 E-value: 8.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 258 MVRLDALQVPTFRVTMYGGSLFRSSISAVPFLLPLLFQvGFGMDPFHSGLLVLAVFVGNLTIKPATTPLIRWLGFRRLLL 337
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501535191 338 INGALNVCSLLACALLTPqtpVWAIMLILYLGGVFRSIQFTGVSTLAFADVPAAQMSDANTLFSTASQLAVGLGITLGAI 417
Cdd:COG2814 80 LGLLLFALGSLLCALAPS---LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
170 180 190
....*....|....*....|....*....|....*...
gi 501535191 418 GIRLgeqvgdwlhlstlpgISFRLSFVFIAVICLVGMI 455
Cdd:COG2814 157 LADL---------------FGWRWVFLVNAVLALLALL 179
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