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Conserved domains on  [gi|501408181|ref|WP_012439747|]
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recombinase family protein [Erwinia tasmaniensis]

Protein Classification

recombinase family protein( domain architecture ID 10132949)

recombinase family protein is a serine recombinase that catalyzes the site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme

CATH:  3.40.50.1390
Gene Ontology:  GO:0000150|GO:0003677|GO:0006310|GO:0015074
PubMed:  21645851|26104451|11972771|16077726|9348666
SCOP:  3000065

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SR_Res_par cd03767
Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; ...
 3-152 4.12e-76

Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subgroup is composed of proteins similar to the E. coli resolvase found in the par region of the RP4 plasmid, which encodes a highly efficient partitioning system. This protein is part of a complex stabilization system involved in the resolution of plasmid dimers during cell division. Similar to Tn3 and other resolvases, members of this family may contain a C-terminal DNA binding domain.


:

Pssm-ID: 239736 [Multi-domain]  Cd Length: 146  Bit Score: 225.67  E-value: 4.12e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181   3 IRAYLRASTEDQFADRAKEMLEQFVQERGHKIASYYRENISGTKLDRPELGRLLMDSHHNDILLIEQIDRLTRLSNSDWM 82
Cdd:cd03767    1 IRAYLRASTDEQDATRAKESLEAFATERGFYIAGFYVENASGAKLDRPELFRLLDDAQSGDVLLVEQIDRLSRLPLDDWE 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181  83 TLKRQIEKHELRIVSLDVPTSWQALSDKDpsqaDPITRAVITAINNMLIDLMAAMSHKDWLSRRQRQKQG 152
Cdd:cd03767   81 TLKASIAAKGLRVVSLDLPTSHSALAAED----NDFTGRILSAINDMLLDLLAAMARKDYEDRRERQKQG 146
 
Name Accession Description Interval E-value
SR_Res_par cd03767
Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; ...
 3-152 4.12e-76

Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subgroup is composed of proteins similar to the E. coli resolvase found in the par region of the RP4 plasmid, which encodes a highly efficient partitioning system. This protein is part of a complex stabilization system involved in the resolution of plasmid dimers during cell division. Similar to Tn3 and other resolvases, members of this family may contain a C-terminal DNA binding domain.


Pssm-ID: 239736 [Multi-domain]  Cd Length: 146  Bit Score: 225.67  E-value: 4.12e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181   3 IRAYLRASTEDQFADRAKEMLEQFVQERGHKIASYYRENISGTKLDRPELGRLLMDSHHNDILLIEQIDRLTRLSNSDWM 82
Cdd:cd03767    1 IRAYLRASTDEQDATRAKESLEAFATERGFYIAGFYVENASGAKLDRPELFRLLDDAQSGDVLLVEQIDRLSRLPLDDWE 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181  83 TLKRQIEKHELRIVSLDVPTSWQALSDKDpsqaDPITRAVITAINNMLIDLMAAMSHKDWLSRRQRQKQG 152
Cdd:cd03767   81 TLKASIAAKGLRVVSLDLPTSHSALAAED----NDFTGRILSAINDMLLDLLAAMARKDYEDRRERQKQG 146
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 1-203 4.53e-27

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 106.26  E-value: 4.53e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181   1 MFIRAYLRASTEDQFA---DRAKEMLEQFVQERGHKIASYYREN-ISGTKLDRPELGRLLMD--SHHNDILLIEQIDRLT 74
Cdd:COG1961    2 MRAAGYARVSTDDQEGlslERQREALRAYAEKAGWEIVRIYVDEgVSGTSKDRPGLQRLLADlrAGKFDTLVVWKLDRLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181  75 RlSNSDWMTLKRQIEKHELRIVSLDvptswqalsdkdpsqaDPITRAviTAINNMLIDLMAAMSHKDWLSRRQRQKQGIE 154
Cdd:COG1961   82 R-NLADLLELVEELKERGVRLISLT----------------EGIDTS--TPMGRLLLTILAAFAEFERELISERTRAGLA 142

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 501408181 155 RAHALGKYRGKqadqerhqKVLYYRQVKKLSIHETAD----------ATGYSPSQICRI 203
Cdd:COG1961  143 AAKARGKYLGR--------PPYGYRDPKKLVIDEEEAevvrrifelyLEGKSLREIARE 193
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 5-162 1.22e-24

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 94.61  E-value: 1.22e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181     5 AYLRASTEDQFA---DRAKEMLEQFVQERGHKIASYYREN-ISGTKLDRPELGRLLMDSHHNDI--LLIEQIDRLTRlSN 78
Cdd:smart00857   3 GYARVSTDDQADgslERQLEALRAYAERNGWEVVRIYEDEgVSGKKADRPGLQRLLADLRAGDIdvLVVYKLDRLGR-SL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181    79 SDWMTLKRQIEKHELRIVSLDvptswQALSDKDpsqadpitraviTAINNMLIDLMAAMSHKDWLSRRQRQKQGIERAHA 158
Cdd:smart00857  82 RDLLALLELLEEKGVRLVSLK-----EGILDTS------------TPAGRLLLDILAALAEFERELISERTKAGLARAAA 144


                   ....
gi 501408181   159 LGKY 162
Cdd:smart00857 145 RGRW 148
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 5-162 7.61e-19

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 79.24  E-value: 7.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181    5 AYLRASTEDQ--FADRAKEMLEQFVQERGhKIASYYRENISGTKLDRPELGRLLMD--SHHNDILLIEQIDRLTRlSNSD 80
Cdd:pfam00239   3 GYARVSTEDQddSLERQLEALRAYAACNG-KIVEFEDKGVSGRKLDRPGLQRLLALlrAGKGDVLVVYKLDRLGR-SLRD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181   81 WMTLKRQIEKHELRIVSLDvptswqalsdkdpsqaDPITRAviTAINNMLIDLMAAMSHKDWLSRRQRQKQGIERAHALG 160
Cdd:pfam00239  81 LLTLVEELREKGVDLVSLD----------------EGIDTS--TPMGRLLLTILAALAEFERALIRERTRAGLAAAAARG 142


                  ..
gi 501408181  161 KY 162
Cdd:pfam00239 143 KL 144
mpi PRK13413
master DNA invertase Mpi family serine-type recombinase;
3-75 9.35e-10

master DNA invertase Mpi family serine-type recombinase;


Pssm-ID: 184041 [Multi-domain]  Cd Length: 200  Bit Score: 55.88  E-value: 9.35e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501408181   3 IRAYLRASTEDQFADRAKEMLEQFVQERGHKIASYYRENISGTKL--DRpELGRLLMDSHHNDILLIEQIDRLTR 75
Cdd:PRK13413   2 IYAYIRVSTDKQTVENQRFEITNFAEKNNLTIDKWIEETISGTKSykDR-KLGKLLKKMRKGDILIVSELSRLGR 75
 
Name Accession Description Interval E-value
SR_Res_par cd03767
Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; ...
 3-152 4.12e-76

Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subgroup is composed of proteins similar to the E. coli resolvase found in the par region of the RP4 plasmid, which encodes a highly efficient partitioning system. This protein is part of a complex stabilization system involved in the resolution of plasmid dimers during cell division. Similar to Tn3 and other resolvases, members of this family may contain a C-terminal DNA binding domain.


Pssm-ID: 239736 [Multi-domain]  Cd Length: 146  Bit Score: 225.67  E-value: 4.12e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181   3 IRAYLRASTEDQFADRAKEMLEQFVQERGHKIASYYRENISGTKLDRPELGRLLMDSHHNDILLIEQIDRLTRLSNSDWM 82
Cdd:cd03767    1 IRAYLRASTDEQDATRAKESLEAFATERGFYIAGFYVENASGAKLDRPELFRLLDDAQSGDVLLVEQIDRLSRLPLDDWE 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181  83 TLKRQIEKHELRIVSLDVPTSWQALSDKDpsqaDPITRAVITAINNMLIDLMAAMSHKDWLSRRQRQKQG 152
Cdd:cd03767   81 TLKASIAAKGLRVVSLDLPTSHSALAAED----NDFTGRILSAINDMLLDLLAAMARKDYEDRRERQKQG 146
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 1-203 4.53e-27

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 106.26  E-value: 4.53e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181   1 MFIRAYLRASTEDQFA---DRAKEMLEQFVQERGHKIASYYREN-ISGTKLDRPELGRLLMD--SHHNDILLIEQIDRLT 74
Cdd:COG1961    2 MRAAGYARVSTDDQEGlslERQREALRAYAEKAGWEIVRIYVDEgVSGTSKDRPGLQRLLADlrAGKFDTLVVWKLDRLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181  75 RlSNSDWMTLKRQIEKHELRIVSLDvptswqalsdkdpsqaDPITRAviTAINNMLIDLMAAMSHKDWLSRRQRQKQGIE 154
Cdd:COG1961   82 R-NLADLLELVEELKERGVRLISLT----------------EGIDTS--TPMGRLLLTILAAFAEFERELISERTRAGLA 142

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 501408181 155 RAHALGKYRGKqadqerhqKVLYYRQVKKLSIHETAD----------ATGYSPSQICRI 203
Cdd:COG1961  143 AAKARGKYLGR--------PPYGYRDPKKLVIDEEEAevvrrifelyLEGKSLREIARE 193
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 5-162 1.22e-24

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 94.61  E-value: 1.22e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181     5 AYLRASTEDQFA---DRAKEMLEQFVQERGHKIASYYREN-ISGTKLDRPELGRLLMDSHHNDI--LLIEQIDRLTRlSN 78
Cdd:smart00857   3 GYARVSTDDQADgslERQLEALRAYAERNGWEVVRIYEDEgVSGKKADRPGLQRLLADLRAGDIdvLVVYKLDRLGR-SL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181    79 SDWMTLKRQIEKHELRIVSLDvptswQALSDKDpsqadpitraviTAINNMLIDLMAAMSHKDWLSRRQRQKQGIERAHA 158
Cdd:smart00857  82 RDLLALLELLEEKGVRLVSLK-----EGILDTS------------TPAGRLLLDILAALAEFERELISERTKAGLARAAA 144


                   ....
gi 501408181   159 LGKY 162
Cdd:smart00857 145 RGRW 148
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 5-162 7.61e-19

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 79.24  E-value: 7.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181    5 AYLRASTEDQ--FADRAKEMLEQFVQERGhKIASYYRENISGTKLDRPELGRLLMD--SHHNDILLIEQIDRLTRlSNSD 80
Cdd:pfam00239   3 GYARVSTEDQddSLERQLEALRAYAACNG-KIVEFEDKGVSGRKLDRPGLQRLLALlrAGKGDVLVVYKLDRLGR-SLRD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181   81 WMTLKRQIEKHELRIVSLDvptswqalsdkdpsqaDPITRAviTAINNMLIDLMAAMSHKDWLSRRQRQKQGIERAHALG 160
Cdd:pfam00239  81 LLTLVEELREKGVDLVSLD----------------EGIDTS--TPMGRLLLTILAALAEFERALIRERTRAGLAAAAARG 142


                  ..
gi 501408181  161 KY 162
Cdd:pfam00239 143 KL 144
Ser_Recombinase cd00338
Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or ...
 5-152 8.13e-16

Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.


Pssm-ID: 238206 [Multi-domain]  Cd Length: 137  Bit Score: 71.14  E-value: 8.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181   5 AYLRASTEDQFA----DRAKEMLEQFVQERGHKIASYYREN-ISGTKL-DRPELGRLLMD--SHHNDILLIEQIDRLTRl 76
Cdd:cd00338    1 IYARVSTDKQEQgdslERQREALREYAARNGLEVVGEYEDAgSSATSLvDRPGLQRLLADvkAGKIDVVLVEKLDRLSR- 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501408181  77 SNSDWMTLKRQIEKHELRIVSLDvptswQALSDKDPSqadpitravitaiNNMLIDLMAAMSHKDWLSRRQRQKQG 152
Cdd:cd00338   80 NLVDLLELLELLEAHGVRVVTAD-----GEIDLDSED-------------GRLMLGILAAMAEEESKLISERTKRG 137
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 5-152 1.68e-13

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 64.42  E-value: 1.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501408181   5 AYLRASTEDQFADRAKEMLEQFVQERghKIasyYRENISGTKLDRPELGRLLMDSHHNDILLIEQIDRLTRlSNSDWMTL 84
Cdd:cd03768    3 GYARVSTDDQSLERQLEALKAAGECD--KI---FEEKGSGGKKERPELQKLLEDLREGDTLVVTKLDRLGR-STKDLLEI 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501408181  85 KRQIEKHELRIVSLDvptswQALSDKDPSqadpitravitaiNNMLIDLMAAMSHKDWLSRRQRQKQG 152
Cdd:cd03768   77 VEELREKGVSLRSLT-----EGIDTSTPS-------------GKLMLTILGAFAEFERELIRERTKEG 126
mpi PRK13413
master DNA invertase Mpi family serine-type recombinase;
3-75 9.35e-10

master DNA invertase Mpi family serine-type recombinase;


Pssm-ID: 184041 [Multi-domain]  Cd Length: 200  Bit Score: 55.88  E-value: 9.35e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501408181   3 IRAYLRASTEDQFADRAKEMLEQFVQERGHKIASYYRENISGTKL--DRpELGRLLMDSHHNDILLIEQIDRLTR 75
Cdd:PRK13413   2 IYAYIRVSTDKQTVENQRFEITNFAEKNNLTIDKWIEETISGTKSykDR-KLGKLLKKMRKGDILIVSELSRLGR 75
SR_IS607_transposase_like cd03769
Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members ...
 5-77 1.84e-05

Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subfamily is composed of proteins that catalyze the transposition of insertion sequence (IS) elements such as IS607 from Helicobacter and IS1535 from Mycobacterium, and similar proteins from other bacteria and several archaeal species. IS elements are DNA segments that move to new sites in prokaryotic and eukaryotic genomes causing insertion mutations and gene rearrangements.


Pssm-ID: 239738  Cd Length: 134  Bit Score: 43.02  E-value: 1.84e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501408181   5 AYLRASTEDQFAD--RAKEMLEQFVQERGhKIASYYRENISGTKLDRPELGRLLMDSHHN--DILLIEQIDRLTRLS 77
Cdd:cd03769    3 LYARVSSHDQKDDleRQIERLEAYATAQG-WIVEVIKDIGSGLNEKRKGLLKLLEDVLAGkvERVVITYKDRLARFG 78
SR_TndX_transposase cd03770
Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of ...
 20-75 3.14e-03

Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. TndX mediates the excision and circularization of the conjugative transposon Tn5397 from Clostridium difficile. TnpX is responsible for the movement of the nonconjugative chloramphenicol resistance elements of the Tn4451/3 family. Mobile genetic elements such as transposons are important vehicles for the transmission of virulence and antibiotic resistance in many microorganisms.


Pssm-ID: 239739 [Multi-domain]  Cd Length: 140  Bit Score: 36.58  E-value: 3.14e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 501408181  20 KEMLEQFVQERGHKIASYY-RENISGTKLDRPELGRLLMDSHHN--DILLIEQIDRLTR 75
Cdd:cd03770   24 KAILEEYAKENGLENIRHYiDDGFSGTTFDRPGFNRMIEDIEAGkiDIVIVKDMSRLGR 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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