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Conserved domains on  [gi|501390570|ref|WP_012422136|]
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ATP-dependent Clp protease ATP-binding subunit [Borrelia hermsii]

Protein Classification

ATP-dependent Clp protease ATP-binding subunit( domain architecture ID 1004404)

ClpA/ClpB family ATP-dependent Clp protease ATP-binding subunit is a component of the Clp chaperone-protease complex that is involved in protein degradation and disaggregation

Gene Ontology:  GO:0016887|GO:0005524|GO:0009368|GO:0043335
PubMed:  25870262|11868279|16879409|2185473|29165246|36329286

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
clpA super family cl35982
ATP-dependent Clp protease ATP-binding subunit; Provisional
 20-754 1.28e-96

ATP-dependent Clp protease ATP-binding subunit; Provisional


The actual alignment was detected with superfamily member PRK11034:

Pssm-ID: 236828 [Multi-domain]  Cd Length: 758  Bit Score: 316.39  E-value: 1.28e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570  20 ERKHLVFTEEHIFYSLISSEKIKELLSLCTLDFYNFNKILEGFFKQlplresdiSDYLFKMNDLYQEIIDTICYYkkpyR 99
Cdd:PRK11034  19 EHRHEFMTVEHLLLALLSNPSAREALEACSVDLVALRQELEAFIEQ--------TTPVLPASEEERDTQPTLSFQ----R 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 100 LQEKDLLWVLVRKRKNTildallkSGFNL--TIFDKIIEVYDYLGSDLDLSSLeneklvesDLFN---KGI--DRDGGLS 172
Cdd:PRK11034  87 VLQRAVFHVQSSGRSEV-------TGANVlvAIFSEQESQAAYLLRKHEVSRL--------DVVNfisHGTrkDEPSQSS 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 173 IFEEDYFKLEQSDDsldDNNVEDFLVNvIDSLDPNLEKNPLIGRKKELCKLIQVMLRKHKSNPIVFGEPGVGKTILLQGL 252
Cdd:PRK11034 152 DPGSQPNSEEQAGG---EERMENFTTN-LNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGVGKTAIAEGL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 253 AYMIKAGQVPQELAGYEVYSLDIGRLISGTRYRGDLEDRVNKLLDFLYFKKKVILFIDEIHMIVGAGATSFSNIDVSNLL 332
Cdd:PRK11034 228 AWRIVQGDVPEVMADCTIYSLDIGSLLAGTKYRGDFEKRFKALLKQLEQDTNSILFIDEIHTIIGAGAASGGQVDAANLI 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 333 KPILTLGEVKFIGATTKYEYQKFFLKDKALIRRFHSIELREPSFEDTYIILKGAKEQYEKHHNVEYTDEAIWASITMS-K 411
Cdd:PRK11034 308 KPLLSSGKIRVIGSTTYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAHHDVRYTAKAVRAAVELAvK 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 412 YMKDRFLPDKAFDLLDGLGAKFKL---EGNRKVITADDVRDFVKSMIGTNIFNFDAYDQDLMINLEHKIRESMIIDEEIL 488
Cdd:PRK11034 388 YINDRHLPDKAIDVIDEAGARARLmpvSKRKKTVNVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAI 467

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 489 SDLILHIKLLRIKFLFKNNTLGIFILMGSSDVDKNKLSGILSEELKIPKLTLGVSEYGDFDGINRLIGPVYGSESYDEFT 568
Cdd:PRK11034 468 EALTEAIKMSRAGLGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLRFDMSEYMERHTVSRLIGAPPGYVGFDQGG 547

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 569 TFFKFLSKSSSSIIFLSDFDKSSKRVIEFFFEGFNTGRLFDSLGRSVSLSDSIILIDINIEYRELA--SIGFKNE--TLN 644
Cdd:PRK11034 548 LLTDAVIKHPHAVLLLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVVLVMTTNAGVRETErkSIGLIHQdnSTD 627

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 645 GRSLLEKRFSSQFLDLVDHIFFFRPVGESDFEKAIIEEMNNFVKILKNEKIDVFFEENIVDYFQNKTYGSGLGIKSVSKI 724
Cdd:PRK11034 628 AMEEIKKIFTPEFRNRLDNIIWFDHLSTDVIHQVVDKFIVELQAQLDQKGVSLEVSQEARDWLAEKGYDRAMGARPMARV 707

                        730       740       750
                 ....*....|....*....|....*....|
gi 501390570 725 VVKEIGSLLVNDMISKKFKENDKIRVYIDE 754
Cdd:PRK11034 708 IQDNLKKPLANELLFGSLVDGGQVTVALDK 737
 
Name Accession Description Interval E-value
clpA PRK11034
ATP-dependent Clp protease ATP-binding subunit; Provisional
 20-754 1.28e-96

ATP-dependent Clp protease ATP-binding subunit; Provisional


Pssm-ID: 236828 [Multi-domain]  Cd Length: 758  Bit Score: 316.39  E-value: 1.28e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570  20 ERKHLVFTEEHIFYSLISSEKIKELLSLCTLDFYNFNKILEGFFKQlplresdiSDYLFKMNDLYQEIIDTICYYkkpyR 99
Cdd:PRK11034  19 EHRHEFMTVEHLLLALLSNPSAREALEACSVDLVALRQELEAFIEQ--------TTPVLPASEEERDTQPTLSFQ----R 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 100 LQEKDLLWVLVRKRKNTildallkSGFNL--TIFDKIIEVYDYLGSDLDLSSLeneklvesDLFN---KGI--DRDGGLS 172
Cdd:PRK11034  87 VLQRAVFHVQSSGRSEV-------TGANVlvAIFSEQESQAAYLLRKHEVSRL--------DVVNfisHGTrkDEPSQSS 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 173 IFEEDYFKLEQSDDsldDNNVEDFLVNvIDSLDPNLEKNPLIGRKKELCKLIQVMLRKHKSNPIVFGEPGVGKTILLQGL 252
Cdd:PRK11034 152 DPGSQPNSEEQAGG---EERMENFTTN-LNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGVGKTAIAEGL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 253 AYMIKAGQVPQELAGYEVYSLDIGRLISGTRYRGDLEDRVNKLLDFLYFKKKVILFIDEIHMIVGAGATSFSNIDVSNLL 332
Cdd:PRK11034 228 AWRIVQGDVPEVMADCTIYSLDIGSLLAGTKYRGDFEKRFKALLKQLEQDTNSILFIDEIHTIIGAGAASGGQVDAANLI 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 333 KPILTLGEVKFIGATTKYEYQKFFLKDKALIRRFHSIELREPSFEDTYIILKGAKEQYEKHHNVEYTDEAIWASITMS-K 411
Cdd:PRK11034 308 KPLLSSGKIRVIGSTTYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAHHDVRYTAKAVRAAVELAvK 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 412 YMKDRFLPDKAFDLLDGLGAKFKL---EGNRKVITADDVRDFVKSMIGTNIFNFDAYDQDLMINLEHKIRESMIIDEEIL 488
Cdd:PRK11034 388 YINDRHLPDKAIDVIDEAGARARLmpvSKRKKTVNVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAI 467

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 489 SDLILHIKLLRIKFLFKNNTLGIFILMGSSDVDKNKLSGILSEELKIPKLTLGVSEYGDFDGINRLIGPVYGSESYDEFT 568
Cdd:PRK11034 468 EALTEAIKMSRAGLGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLRFDMSEYMERHTVSRLIGAPPGYVGFDQGG 547

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 569 TFFKFLSKSSSSIIFLSDFDKSSKRVIEFFFEGFNTGRLFDSLGRSVSLSDSIILIDINIEYRELA--SIGFKNE--TLN 644
Cdd:PRK11034 548 LLTDAVIKHPHAVLLLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVVLVMTTNAGVRETErkSIGLIHQdnSTD 627

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 645 GRSLLEKRFSSQFLDLVDHIFFFRPVGESDFEKAIIEEMNNFVKILKNEKIDVFFEENIVDYFQNKTYGSGLGIKSVSKI 724
Cdd:PRK11034 628 AMEEIKKIFTPEFRNRLDNIIWFDHLSTDVIHQVVDKFIVELQAQLDQKGVSLEVSQEARDWLAEKGYDRAMGARPMARV 707

                        730       740       750
                 ....*....|....*....|....*....|
gi 501390570 725 VVKEIGSLLVNDMISKKFKENDKIRVYIDE 754
Cdd:PRK11034 708 IQDNLKKPLANELLFGSLVDGGQVTVALDK 737
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 212-440 4.31e-83

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 281.97  E-value: 4.31e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 212 PLIGRKKELCKLIQVMLRKHKSNPIVFGEPGVGKTILLQGLAYMIKAGQVPQELAGYEVYSLDIGRLISGTRYRGDLEDR 291
Cdd:COG0542  180 PVIGRDEEIRRVIQILSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGDVPESLKDKRVLSLDLGALVAGAKYRGEFEER 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 292 VNKLLDFLY-FKKKVILFIDEIHMIVGAGATSfSNIDVSNLLKPILTLGEVKFIGATTKYEYQKFFLKDKALIRRFHSIE 370
Cdd:COG0542  260 LKAVLDEVKkSEGNIILFIDELHTLVGAGGAE-GAMDAANLLKPALARGELRCIGATTLDEYRKYIEKDAALERRFQPVL 338

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501390570 371 LREPSFEDTYIILKGAKEQYEKHHNVEYTDEAIWASITMSK-YMKDRFLPDKAFDLLDGLGAKFKLEGNRK 440
Cdd:COG0542  339 VEEPSVEDTISILRGLKERYEAHHGVRITDEALVAAVRLSDrYITDRFLPDKAIDLIDEAAARVRMEIDSK 409
VI_ClpV1 TIGR03345
type VI secretion ATPase, ClpV1 family; Members of this protein family are homologs of ClpB, ...
 212-427 2.12e-61

type VI secretion ATPase, ClpV1 family; Members of this protein family are homologs of ClpB, an ATPase associated with chaperone-related functions. These ClpB homologs, designated ClpV1, are a key component of the bacterial pathogenicity-associated type VI secretion system. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274528 [Multi-domain]  Cd Length: 852  Bit Score: 221.74  E-value: 2.12e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570  212 PLIGRKKELCKLIQVMLRKHKSNPIVFGEPGVGKTILLQGLAYMIKAGQVPQELAGYEVYSLDIGRLISGTRYRGDLEDR 291
Cdd:TIGR03345 188 PVLGRDDEIRQMIDILLRRRQNNPILTGEAGVGKTAVVEGLALRIAAGDVPPALRNVRLLSLDLGLLQAGASVKGEFENR 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570  292 VNKLLDFLyfkKK----VILFIDEIHMIVGAGATSFSNiDVSNLLKPILTLGEVKFIGATTKYEYQKFFLKDKALIRRFH 367
Cdd:TIGR03345 268 LKSVIDEV---KAspqpIILFIDEAHTLIGAGGQAGQG-DAANLLKPALARGELRTIAATTWAEYKKYFEKDPALTRRFQ 343

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501390570  368 SIELREPSFEDTYIILKGAKEQYEKHHNVEYTDEAIWASITMS-KYMKDRFLPDKAFDLLD 427
Cdd:TIGR03345 344 VVKVEEPDEETAIRMLRGLAPVLEKHHGVLILDEAVVAAVELShRYIPGRQLPDKAVSLLD 404
AAA_lid_9 pfam17871
AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 375-449 1.65e-24

AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465544 [Multi-domain]  Cd Length: 104  Bit Score: 98.33  E-value: 1.65e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501390570  375 SFEDTYIILKGAKEQYEKHHNVEYTDEAIWASITMSK-YMKDRFLPDKAFDLLDGLGAKFKLEGNRKVITADDVRD 449
Cdd:pfam17871   1 SVEEAIEILRGLKPKYEKHHGVRISDEALEAAVKLSKrYITDRFLPDKAIDLLDEACARVRLSQESKPEELEDLER 76
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 214-369 2.08e-14

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 71.02  E-value: 2.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 214 IGRKKELCKLIQVMLRKHKSNPIVFGEPGVGKTILLQGLAYMIKagqvpqeLAGYEVYSLDIGRLISGTRYRGDLEDRVN 293
Cdd:cd00009    1 VGQEEAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANELF-------RPGAPFLYLNASDLLEGLVVAELFGHFLV 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501390570 294 KLLDFL-YFKKKVILFIDEIHMI-VGAGATSFSNIDVsnLLKPILTLGEVKFIGATTKYEYQKFflkDKALIRRFHSI 369
Cdd:cd00009   74 RLLFELaEKAKPGVLFIDEIDSLsRGAQNALLRVLET--LNDLRIDRENVRVIGATNRPLLGDL---DRALYDRLDIR 146
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 236-366 3.43e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 50.45  E-value: 3.43e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570   236 IVFGEPGVGKTILLQGLAYMIKAGQVPQ-----ELAGYEVYSLDIGRLISGTRYRGDLEDRVNKLLDFLYFKKKVILFID 310
Cdd:smart00382   6 LIVGPPGSGKTTLARALARELGPPGGGViyidgEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDVLILD 85

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 501390570   311 EIHMIVGAGAT-SFSNIDVSNLLKPILTLGEVKFIGATTKYEyqkfFLKDKALIRRF 366
Cdd:smart00382  86 EITSLLDAEQEaLLLLLEELRLLLLLKSEKNLTVILTTNDEK----DLGPALLRRRF 138
 
Name Accession Description Interval E-value
clpA PRK11034
ATP-dependent Clp protease ATP-binding subunit; Provisional
 20-754 1.28e-96

ATP-dependent Clp protease ATP-binding subunit; Provisional


Pssm-ID: 236828 [Multi-domain]  Cd Length: 758  Bit Score: 316.39  E-value: 1.28e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570  20 ERKHLVFTEEHIFYSLISSEKIKELLSLCTLDFYNFNKILEGFFKQlplresdiSDYLFKMNDLYQEIIDTICYYkkpyR 99
Cdd:PRK11034  19 EHRHEFMTVEHLLLALLSNPSAREALEACSVDLVALRQELEAFIEQ--------TTPVLPASEEERDTQPTLSFQ----R 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 100 LQEKDLLWVLVRKRKNTildallkSGFNL--TIFDKIIEVYDYLGSDLDLSSLeneklvesDLFN---KGI--DRDGGLS 172
Cdd:PRK11034  87 VLQRAVFHVQSSGRSEV-------TGANVlvAIFSEQESQAAYLLRKHEVSRL--------DVVNfisHGTrkDEPSQSS 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 173 IFEEDYFKLEQSDDsldDNNVEDFLVNvIDSLDPNLEKNPLIGRKKELCKLIQVMLRKHKSNPIVFGEPGVGKTILLQGL 252
Cdd:PRK11034 152 DPGSQPNSEEQAGG---EERMENFTTN-LNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGVGKTAIAEGL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 253 AYMIKAGQVPQELAGYEVYSLDIGRLISGTRYRGDLEDRVNKLLDFLYFKKKVILFIDEIHMIVGAGATSFSNIDVSNLL 332
Cdd:PRK11034 228 AWRIVQGDVPEVMADCTIYSLDIGSLLAGTKYRGDFEKRFKALLKQLEQDTNSILFIDEIHTIIGAGAASGGQVDAANLI 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 333 KPILTLGEVKFIGATTKYEYQKFFLKDKALIRRFHSIELREPSFEDTYIILKGAKEQYEKHHNVEYTDEAIWASITMS-K 411
Cdd:PRK11034 308 KPLLSSGKIRVIGSTTYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAHHDVRYTAKAVRAAVELAvK 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 412 YMKDRFLPDKAFDLLDGLGAKFKL---EGNRKVITADDVRDFVKSMIGTNIFNFDAYDQDLMINLEHKIRESMIIDEEIL 488
Cdd:PRK11034 388 YINDRHLPDKAIDVIDEAGARARLmpvSKRKKTVNVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAI 467

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 489 SDLILHIKLLRIKFLFKNNTLGIFILMGSSDVDKNKLSGILSEELKIPKLTLGVSEYGDFDGINRLIGPVYGSESYDEFT 568
Cdd:PRK11034 468 EALTEAIKMSRAGLGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLRFDMSEYMERHTVSRLIGAPPGYVGFDQGG 547

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 569 TFFKFLSKSSSSIIFLSDFDKSSKRVIEFFFEGFNTGRLFDSLGRSVSLSDSIILIDINIEYRELA--SIGFKNE--TLN 644
Cdd:PRK11034 548 LLTDAVIKHPHAVLLLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVVLVMTTNAGVRETErkSIGLIHQdnSTD 627

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 645 GRSLLEKRFSSQFLDLVDHIFFFRPVGESDFEKAIIEEMNNFVKILKNEKIDVFFEENIVDYFQNKTYGSGLGIKSVSKI 724
Cdd:PRK11034 628 AMEEIKKIFTPEFRNRLDNIIWFDHLSTDVIHQVVDKFIVELQAQLDQKGVSLEVSQEARDWLAEKGYDRAMGARPMARV 707

                        730       740       750
                 ....*....|....*....|....*....|
gi 501390570 725 VVKEIGSLLVNDMISKKFKENDKIRVYIDE 754
Cdd:PRK11034 708 IQDNLKKPLANELLFGSLVDGGQVTVALDK 737
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 212-440 4.31e-83

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 281.97  E-value: 4.31e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 212 PLIGRKKELCKLIQVMLRKHKSNPIVFGEPGVGKTILLQGLAYMIKAGQVPQELAGYEVYSLDIGRLISGTRYRGDLEDR 291
Cdd:COG0542  180 PVIGRDEEIRRVIQILSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGDVPESLKDKRVLSLDLGALVAGAKYRGEFEER 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 292 VNKLLDFLY-FKKKVILFIDEIHMIVGAGATSfSNIDVSNLLKPILTLGEVKFIGATTKYEYQKFFLKDKALIRRFHSIE 370
Cdd:COG0542  260 LKAVLDEVKkSEGNIILFIDELHTLVGAGGAE-GAMDAANLLKPALARGELRCIGATTLDEYRKYIEKDAALERRFQPVL 338

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501390570 371 LREPSFEDTYIILKGAKEQYEKHHNVEYTDEAIWASITMSK-YMKDRFLPDKAFDLLDGLGAKFKLEGNRK 440
Cdd:COG0542  339 VEEPSVEDTISILRGLKERYEAHHGVRITDEALVAAVRLSDrYITDRFLPDKAIDLIDEAAARVRMEIDSK 409
clpC CHL00095
Clp protease ATP binding subunit
 194-761 5.92e-83

Clp protease ATP binding subunit


Pssm-ID: 214361 [Multi-domain]  Cd Length: 821  Bit Score: 281.17  E-value: 5.92e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 194 EDFLVNVIDS-LDPNLekNPLIGRKKELCKLIQVMLRKHKSNPIVFGEPGVGKTILLQGLAYMIKAGQVPQELAGYEVYS 272
Cdd:CHL00095 163 EEFGTNLTKEaIDGNL--DPVIGREKEIERVIQILGRRTKNNPILIGEPGVGKTAIAEGLAQRIVNRDVPDILEDKLVIT 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 273 LDIGRLISGTRYRGDLEDRVNKLLDFLYFKKKVILFIDEIHMIVGAGATSfSNIDVSNLLKPILTLGEVKFIGATTKYEY 352
Cdd:CHL00095 241 LDIGLLLAGTKYRGEFEERLKRIFDEIQENNNIILVIDEVHTLIGAGAAE-GAIDAANILKPALARGELQCIGATTLDEY 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 353 QKFFLKDKALIRRFHSIELREPSFEDTYIILKGAKEQYEKHHNVEYTDEAIWASITMS-KYMKDRFLPDKAFDLLDGLGA 431
Cdd:CHL00095 320 RKHIEKDPALERRFQPVYVGEPSVEETIEILFGLRSRYEKHHNLSISDKALEAAAKLSdQYIADRFLPDKAIDLLDEAGS 399

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 432 KFKLE--------------------------------------------------------------GNRKVITADDVRD 449
Cdd:CHL00095 400 RVRLInsrlppaareldkelreilkdkdeaireqdfetakqlrdremevraqiaaiiqskkteeekrLEVPVVTEEDIAE 479

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 450 FVKSMIGTNIFNFDAYDQDLMINLEHKIRESMIIDEEILSDLILHIKLLRIKFLFKNNTLGIFILMGSSDVDKNKLSGIL 529
Cdd:CHL00095 480 IVSAWTGIPVNKLTKSESEKLLHMEETLHKRIIGQDEAVVAVSKAIRRARVGLKNPNRPIASFLFSGPTGVGKTELTKAL 559

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 530 ------SEELKIpklTLGVSEYGDFDGINRLIGPVYGSESYDEFTTFFKFLSKSSSSIIFLSDFDKSSKRVIEFFFEGFN 603
Cdd:CHL00095 560 asyffgSEDAMI---RLDMSEYMEKHTVSKLIGSPPGYVGYNEGGQLTEAVRKKPYTVVLFDEIEKAHPDIFNLLLQILD 636

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 604 TGRLFDSLGRSVSLSDSIILIDINIEYREL----ASIGFK------NETLNGR------SLLEKRFSSQFLDLVDHIFFF 667
Cdd:CHL00095 637 DGRLTDSKGRTIDFKNTLIIMTSNLGSKVIetnsGGLGFElsenqlSEKQYKRlsnlvnEELKQFFRPEFLNRLDEIIVF 716

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 668 RPVGESDFeKAIIEEM-NNFVKILKNEKIDVFFEENIVDYFQNKTYGSGLGIKSVSKIVVKEIGSLLVNDMISKKFKEND 746
Cdd:CHL00095 717 RQLTKNDV-WEIAEIMlKNLFKRLNEQGIQLEVTERIKTLLIEEGYNPLYGARPLRRAIMRLLEDPLAEEVLSFKIKPGD 795

                        650
                 ....*....|....*
gi 501390570 747 KIRVYIDETMKYELL 761
Cdd:CHL00095 796 IIIVDVNDEKEVKIL 810
PRK10865 PRK10865
ATP-dependent chaperone ClpB;
211-440 1.31e-64

ATP-dependent chaperone ClpB;


Pssm-ID: 182791 [Multi-domain]  Cd Length: 857  Bit Score: 231.27  E-value: 1.31e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 211 NPLIGRKKELCKLIQVMLRKHKSNPIVFGEPGVGKTILLQGLAYMIKAGQVPQELAGYEVYSLDIGRLISGTRYRGDLED 290
Cdd:PRK10865 178 DPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKGRRVLALDMGALVAGAKYRGEFEE 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 291 RVNKLLDFLYFKK-KVILFIDEIHMIVGAGATSfSNIDVSNLLKPILTLGEVKFIGATTKYEYQKFFLKDKALIRRFHSI 369
Cdd:PRK10865 258 RLKGVLNDLAKQEgNVILFIDELHTMVGAGKAD-GAMDAGNMLKPALARGELHCVGATTLDEYRQYIEKDAALERRFQKV 336

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 501390570 370 ELREPSFEDTYIILKGAKEQYEKHHNVEYTDEAIWASITMS-KYMKDRFLPDKAFDLLDGLGAKFKLEGNRK 440
Cdd:PRK10865 337 FVAEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLShRYIADRQLPDKAIDLIDEAASSIRMQIDSK 408
VI_ClpV1 TIGR03345
type VI secretion ATPase, ClpV1 family; Members of this protein family are homologs of ClpB, ...
 212-427 2.12e-61

type VI secretion ATPase, ClpV1 family; Members of this protein family are homologs of ClpB, an ATPase associated with chaperone-related functions. These ClpB homologs, designated ClpV1, are a key component of the bacterial pathogenicity-associated type VI secretion system. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274528 [Multi-domain]  Cd Length: 852  Bit Score: 221.74  E-value: 2.12e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570  212 PLIGRKKELCKLIQVMLRKHKSNPIVFGEPGVGKTILLQGLAYMIKAGQVPQELAGYEVYSLDIGRLISGTRYRGDLEDR 291
Cdd:TIGR03345 188 PVLGRDDEIRQMIDILLRRRQNNPILTGEAGVGKTAVVEGLALRIAAGDVPPALRNVRLLSLDLGLLQAGASVKGEFENR 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570  292 VNKLLDFLyfkKK----VILFIDEIHMIVGAGATSFSNiDVSNLLKPILTLGEVKFIGATTKYEYQKFFLKDKALIRRFH 367
Cdd:TIGR03345 268 LKSVIDEV---KAspqpIILFIDEAHTLIGAGGQAGQG-DAANLLKPALARGELRTIAATTWAEYKKYFEKDPALTRRFQ 343

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501390570  368 SIELREPSFEDTYIILKGAKEQYEKHHNVEYTDEAIWASITMS-KYMKDRFLPDKAFDLLD 427
Cdd:TIGR03345 344 VVKVEEPDEETAIRMLRGLAPVLEKHHGVLILDEAVVAAVELShRYIPGRQLPDKAVSLLD 404
AAA_lid_9 pfam17871
AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 375-449 1.65e-24

AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465544 [Multi-domain]  Cd Length: 104  Bit Score: 98.33  E-value: 1.65e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501390570  375 SFEDTYIILKGAKEQYEKHHNVEYTDEAIWASITMSK-YMKDRFLPDKAFDLLDGLGAKFKLEGNRKVITADDVRD 449
Cdd:pfam17871   1 SVEEAIEILRGLKPKYEKHHGVRISDEALEAAVKLSKrYITDRFLPDKAIDLLDEACARVRLSQESKPEELEDLER 76
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 214-369 2.08e-14

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 71.02  E-value: 2.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 214 IGRKKELCKLIQVMLRKHKSNPIVFGEPGVGKTILLQGLAYMIKagqvpqeLAGYEVYSLDIGRLISGTRYRGDLEDRVN 293
Cdd:cd00009    1 VGQEEAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANELF-------RPGAPFLYLNASDLLEGLVVAELFGHFLV 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501390570 294 KLLDFL-YFKKKVILFIDEIHMI-VGAGATSFSNIDVsnLLKPILTLGEVKFIGATTKYEYQKFflkDKALIRRFHSI 369
Cdd:cd00009   74 RLLFELaEKAKPGVLFIDEIDSLsRGAQNALLRVLET--LNDLRIDRENVRVIGATNRPLLGDL---DRALYDRLDIR 146
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 236-366 9.68e-13

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 65.69  E-value: 9.68e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570  236 IVFGEPGVGKTILLQGLAymikagqvpQELaGYEVYSLDIGRLISGtrYRGDLEDRVNKLLDFLYFKKKVILFIDEIHMI 315
Cdd:pfam00004   2 LLYGPPGTGKTTLAKAVA---------KEL-GAPFIEISGSELVSK--YVGESEKRLRELFEAAKKLAPCVIFIDEIDAL 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 501390570  316 VGAGATSFS--NIDVSNLLKPIL-----TLGEVKFIGATTKYEyqkffLKDKALIRRF 366
Cdd:pfam00004  70 AGSRGSGGDseSRRVVNQLLTELdgftsSNSKVIVIAATNRPD-----KLDPALLGRF 122
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 213-410 2.72e-09

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 60.10  E-value: 2.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 213 LIGRKKELCKLIQvmlRKHKSNPIVFGEPGVGKTILlqglAYMIkAGQVpqelaGYEVYSLDIgrLISGTRyrgDLEDRV 292
Cdd:PRK13342  20 LLGPGKPLRRMIE---AGRLSSMILWGPPGTGKTTL----ARII-AGAT-----DAPFEALSA--VTSGVK---DLREVI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 293 NKLLDFLYFKKKVILFIDEIHmivgagatSFSNI--DVsnLLkPILTLGEVKFIGATTkyEyQKFFLKDKALIRRFHSIE 370
Cdd:PRK13342  82 EEARQRRSAGRRTILFIDEIH--------RFNKAqqDA--LL-PHVEDGTITLIGATT--E-NPSFEVNPALLSRAQVFE 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 501390570 371 LREPSFEDTYIILKGAKEQYEKHHnVEYTDEAIWASITMS 410
Cdd:PRK13342 148 LKPLSEEDIEQLLKRALEDKERGL-VELDDEALDALARLA 186
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 236-366 3.43e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 50.45  E-value: 3.43e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570   236 IVFGEPGVGKTILLQGLAYMIKAGQVPQ-----ELAGYEVYSLDIGRLISGTRYRGDLEDRVNKLLDFLYFKKKVILFID 310
Cdd:smart00382   6 LIVGPPGSGKTTLARALARELGPPGGGViyidgEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDVLILD 85

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 501390570   311 EIHMIVGAGAT-SFSNIDVSNLLKPILTLGEVKFIGATTKYEyqkfFLKDKALIRRF 366
Cdd:smart00382  86 EITSLLDAEQEaLLLLLEELRLLLLLKSEKNLTVILTTNDEK----DLGPALLRRRF 138
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
228-384 5.00e-07

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 51.42  E-value: 5.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 228 LRKHKSNP----IVFGEPGVGKTILLQGLAYMIKagqVPqelagyeVYSLDIGRLISgtRYRGDLEDRVNKLLDFLYfKK 303
Cdd:COG1223   27 LRKFGLWPprkiLFYGPPGTGKTMLAEALAGELK---LP-------LLTVRLDSLIG--SYLGETARNLRKLFDFAR-RA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 304 KVILFIDEIHMIvgAGATSFSNI--DVSNLLKPILTL-----GEVKFIGATTKYEyqkffLKDKALIRRF-HSIELREPS 375
Cdd:COG1223   94 PCVIFFDEFDAI--AKDRGDQNDvgEVKRVVNALLQEldglpSGSVVIAATNHPE-----LLDSALWRRFdEVIEFPLPD 166


                 ....*....
gi 501390570 376 FEDTYIILK 384
Cdd:COG1223  167 KEERKEILE 175
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 222-467 5.47e-07

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 52.75  E-value: 5.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 222 KLIQVMLRKHK-SNPIVFGEPGVGKTILlqglAYMIkAGQVpqelaGYEVYSLDIgrLISGTRyrgDLEDRVNKLLDFLY 300
Cdd:COG2256   38 KPLRRAIEAGRlSSMILWGPPGTGKTTL----ARLI-ANAT-----DAEFVALSA--VTSGVK---DIREVIEEARERRA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 301 FKKKVILFIDEIHmivgagatSFsnidvsN------LLkPILTLGEVKFIGATTkyEYQKFFLkDKALIRRFHSIELREP 374
Cdd:COG2256  103 YGRRTILFVDEIH--------RF------NkaqqdaLL-PHVEDGTITLIGATT--ENPSFEV-NSALLSRCRVFVLKPL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 375 SFEDTYIILKGAKEQYEK---HHNVEYTDEAIWASITMSkymkdrflpD----KAFDLLDgLGAKFKLEGNRKVITADDV 447
Cdd:COG2256  165 SEEDLEQLLERALADDERglgGYKLELDDEALEALARLA---------DgdarRALNALE-LAVLSAPPDGVIEITLELV 234

                        250       260
                 ....*....|....*....|....*
gi 501390570 448 RDFvksmIGTNIFNFDA-----YDQ 467
Cdd:COG2256  235 EEA----LQRRALRYDKdgdehYDL 255
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 225-366 1.76e-06

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 48.43  E-value: 1.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 225 QVMLRKHKSNPIVFGEPGVGKTILLQGLAymikagqvpqELAGYEVYSLDIGRLISgtRYRGDLEDRVNKLLDFLYFKKK 304
Cdd:cd19481   19 RRYGLGLPKGILLYGPPGTGKTLLAKALA----------GELGLPLIVVKLSSLLS--KYVGESEKNLRKIFERARRLAP 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501390570 305 VILFIDEIHMIVGAGATSFSNIDVS-------NLLKPILTLGEVKFIGATTKYEyqkffLKDKALIR--RF 366
Cdd:cd19481   87 CILFIDEIDAIGRKRDSSGESGELRrvlnqllTELDGVNSRSKVLVIAATNRPD-----LLDPALLRpgRF 152
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 238-384 4.33e-06

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 49.91  E-value: 4.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 238 FGEPGVGKTILLQGLAymikagqvpqELAGYEVYSLDIGRLISGtrYRGDLEDRVNKLLDFLYFKKKVILFIDEIHMIV- 316
Cdd:COG0464  197 YGPPGTGKTLLARALA----------GELGLPLIEVDLSDLVSK--YVGETEKNLREVFDKARGLAPCVLFIDEADALAg 264

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501390570 317 --GAGATSFSNIDVSNLLK-------PILtlgevkFIGATTkyeyqKFFLKDKALIRRF-HSIELREPSFEDTYIILK 384
Cdd:COG0464  265 krGEVGDGVGRRVVNTLLTemeelrsDVV------VIAATN-----RPDLLDPALLRRFdEIIFFPLPDAEERLEIFR 331
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 505-667 7.67e-06

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 47.17  E-value: 7.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 505 KNNTLGIFILMGSSDVDKNKLSGILSEELKIPK---LTLGVSEYGDFDGINRLIGPVYGSESYDEFTTFFKFLSKSSSSI 581
Cdd:cd19499   37 PNRPIGSFLFLGPTGVGKTELAKALAELLFGDEdnlIRIDMSEYMEKHSVSRLIGAPPGYVGYTEGGQLTEAVRRKPYSV 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 582 IFLSDFDKSSKRVIEFFFEGFNTGRLFDSLGRSVSLSDSIILIDINIeyrelasigfknetlngrsllekrFSSQFLDLV 661
Cdd:cd19499  117 VLLDEIEKAHPDVQNLLLQVLDDGRLTDSHGRTVDFKNTIIIMTSNH------------------------FRPEFLNRI 172


                 ....*.
gi 501390570 662 DHIFFF 667
Cdd:cd19499  173 DEIVVF 178
PRK13341 PRK13341
AAA family ATPase;
233-402 5.07e-05

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 46.97  E-value: 5.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 233 SNPIVFGEPGVGKTILLQGLAYMIKAgqvpqelagyEVYSLDigRLISGTRyrgDLEDRVNKLLDFL-YFKKKVILFIDE 311
Cdd:PRK13341  53 GSLILYGPPGVGKTTLARIIANHTRA----------HFSSLN--AVLAGVK---DLRAEVDRAKERLeRHGKRTILFIDE 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 312 IHMIvgagatsfsNIDVSNLLKPILTLGEVKFIGATTKYEYqkfFLKDKALIRRFHSIELREPSFEDTYIILKGAKEQYE 391
Cdd:PRK13341 118 VHRF---------NKAQQDALLPWVENGTITLIGATTENPY---FEVNKALVSRSRLFRLKSLSDEDLHQLLKRALQDKE 185

                        170
                 ....*....|....
gi 501390570 392 KHH---NVEYTDEA 402
Cdd:PRK13341 186 RGYgdrKVDLEPEA 199
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 238-384 6.21e-05

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 45.77  E-value: 6.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 238 FGEPGVGKTILLQGLAYMIKAGqvpqelagyeVYSLDIGRLISgtRYRGDLEDRVNKLLDFLYFKKKVILFIDEIHMIVG 317
Cdd:COG1222  118 YGPPGTGKTLLAKAVAGELGAP----------FIRVRGSELVS--KYIGEGARNVREVFELAREKAPSIIFIDEIDAIAA 185

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501390570 318 AGATSFSNIDVSNLLKPILT-------LGEVKFIGATTKYEyqkffLKDKALIR--RF-HSIELREPSFEDTYIILK 384
Cdd:COG1222  186 RRTDDGTSGEVQRTVNQLLAeldgfesRGDVLIIAATNRPD-----LLDPALLRpgRFdRVIEVPLPDEEAREEILK 257
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 218-349 2.25e-04

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 42.39  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501390570 218 KELCKLIqVMLRKHK-----------SNPIVFGEPGVGKTILLQGLAYMIKagqVPqelagyeVYSLDIGRLISGTRyrG 286
Cdd:cd19518   10 KELCELL-IHPILPPeyfqhlgveppRGVLLHGPPGCGKTMLANAIAGELK---VP-------FLKISATEIVSGVS--G 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501390570 287 DLEDRVNKLLDFLYFKKKVILFIDEIHMIVGAGATSFSNID---VSNLLKPILTL-------GEVKFIGATTK 349
Cdd:cd19518   77 ESEEKIRELFDQAISNAPCIVFIDEIDAITPKRESAQREMErriVSQLLTCMDELnnektagGPVLVIGATNR 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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