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Conserved domains on  [gi|501316884|ref|WP_012348519|]
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rhombosortase [Leptothrix cholodnii]

Protein Classification

rhomboid family protein( domain architecture ID 229382)

rhomboid family protein may be a membrane-bound serine protease that catalyzes regulated intramembrane proteolysis, resulting in the release of functional polypeptides from their membrane anchors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rhomboid super family cl21536
Rhomboid family; This family contains integral membrane proteins that are related to ...
 36-191 3.33e-23

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


The actual alignment was detected with superfamily member TIGR03902:

Pssm-ID: 451297  Cd Length: 154  Bit Score: 90.32  E-value: 3.33e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501316884   36 EVLSWQPAR-AGAEPWRWWSAAWVHFSDLHWLA-NLLGALLVALLGWFLNPPRAAAWAWALAWPLTHLSLLIQPQLQRYG 113
Cdd:TIGR03902   2 DLLAYDRAAiLDGEWWRLLTGHFVHLNWWHLLMnLAGLLLLWALFGRHLRARRLLLLLLLLSLLISLGLLLFLPSLQWYV 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501316884  114 GLSGVLHAGVAVCATGLCLRGRSTgerglGAAVLAGLLLKVALEQPWAGPLIHVAGWDIAIAPLAHAGGVFWGTLLGA 191
Cdd:TIGR03902  82 GLSGVLHGLFAWGALRDIRYGRRS-----GWLLLLGVIAKLAWEQLFGASAFTAALIGAPVATEAHLAGAISGLLIAL 154
 
Name Accession Description Interval E-value
rhom_GG_sort TIGR03902
rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like ...
 36-191 3.33e-23

rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like intramembrane serine protease. Its species distribution closely matches model TIGR03501, GlyGly-CTERM, which describes a protein targeting domain analogous to LPXTG and PEP-CTERM. In a number of species (Ralstonia eutropha ,R. metallidurans, R. solanacearum, Marinobacter aquaeolei, etc) with just one GlyGly-CTERM protein (i.e., a dedicated system), the rhombosortase and GlyGly-CTERM genes are adjacent.


Pssm-ID: 274845  Cd Length: 154  Bit Score: 90.32  E-value: 3.33e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501316884   36 EVLSWQPAR-AGAEPWRWWSAAWVHFSDLHWLA-NLLGALLVALLGWFLNPPRAAAWAWALAWPLTHLSLLIQPQLQRYG 113
Cdd:TIGR03902   2 DLLAYDRAAiLDGEWWRLLTGHFVHLNWWHLLMnLAGLLLLWALFGRHLRARRLLLLLLLLSLLISLGLLLFLPSLQWYV 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501316884  114 GLSGVLHAGVAVCATGLCLRGRSTgerglGAAVLAGLLLKVALEQPWAGPLIHVAGWDIAIAPLAHAGGVFWGTLLGA 191
Cdd:TIGR03902  82 GLSGVLHGLFAWGALRDIRYGRRS-----GWLLLLGVIAKLAWEQLFGASAFTAALIGAPVATEAHLAGAISGLLIAL 154
 
Name Accession Description Interval E-value
rhom_GG_sort TIGR03902
rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like ...
 36-191 3.33e-23

rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like intramembrane serine protease. Its species distribution closely matches model TIGR03501, GlyGly-CTERM, which describes a protein targeting domain analogous to LPXTG and PEP-CTERM. In a number of species (Ralstonia eutropha ,R. metallidurans, R. solanacearum, Marinobacter aquaeolei, etc) with just one GlyGly-CTERM protein (i.e., a dedicated system), the rhombosortase and GlyGly-CTERM genes are adjacent.


Pssm-ID: 274845  Cd Length: 154  Bit Score: 90.32  E-value: 3.33e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501316884   36 EVLSWQPAR-AGAEPWRWWSAAWVHFSDLHWLA-NLLGALLVALLGWFLNPPRAAAWAWALAWPLTHLSLLIQPQLQRYG 113
Cdd:TIGR03902   2 DLLAYDRAAiLDGEWWRLLTGHFVHLNWWHLLMnLAGLLLLWALFGRHLRARRLLLLLLLLSLLISLGLLLFLPSLQWYV 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501316884  114 GLSGVLHAGVAVCATGLCLRGRSTgerglGAAVLAGLLLKVALEQPWAGPLIHVAGWDIAIAPLAHAGGVFWGTLLGA 191
Cdd:TIGR03902  82 GLSGVLHGLFAWGALRDIRYGRRS-----GWLLLLGVIAKLAWEQLFGASAFTAALIGAPVATEAHLAGAISGLLIAL 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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