NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|501024745|ref|WP_012076859|]
View 

MULTISPECIES: TcpQ domain-containing protein [Pseudomonas]

Protein Classification

conj_PilL and TcpQ domain-containing protein( domain architecture ID 10023706)

conj_PilL and TcpQ domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
conj_PilL TIGR03748
conjugative transfer region protein, TIGR03748 family; This model describes the conserved ...
 55-159 4.37e-57

conjugative transfer region protein, TIGR03748 family; This model describes the conserved N-terminal region of a variable length protein family associated with laterally transfered regions flanked by markers of conjugative plasmid integration and/or transposition. Most members of the family have the lipoprotein signal peptide motif. A member of the family from a pathogenicity island in Salmonella enterica serovar Dublin strain was designated PilL for nomenclature consistency with a neighboring gene for the pilin structural protein PilS. However, the species distribution of this protein family tracks much better with markers of conjugal transfer than with markers of PilS-like pilin structure. [Mobile and extrachromosomal element functions, Plasmid functions]


:

Pssm-ID: 163460  Cd Length: 105  Bit Score: 181.31  E-value: 4.37e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501024745   55 VRYGRYTLVSTQPDAGQRDLMAQIIDVTIPSSMNPSVKDAMQYVMSRSGYSLCPAEAGHVNILYTRPLPAAQYKLGPMTL 134
Cdd:TIGR03748   1 VRYGRYTLVETRPEAAQRDLLNQVIDITIPPSLVATVGDALRYLLRRSGYSLCPASALSEAALLTLPLPAAHRKLGPMTL 80

                          90       100
                  ....*....|....*....|....*
gi 501024745  135 RNTLQVLSGPAWQVKVDEVARQVCF 159
Cdd:TIGR03748  81 RDALQVLAGPAWRLKVDDVTREVCF 105
TcpQ pfam10671
Toxin co-regulated pilus biosynthesis protein Q; The toxin-coregulated pilus (TCP) of Vibrio ...
 292-372 1.30e-21

Toxin co-regulated pilus biosynthesis protein Q; The toxin-coregulated pilus (TCP) of Vibrio cholerae and the soluble TcpF protein that is secreted via the TCP biogenesis apparatus are essential for intestinal colonization in the disease of cholera. TcpQ is part of an outer membrane complex of the TCP biogenesis apparatus, comprised of TcpC and TcpQ, and the TcpQ is required for proper localization of TcpC to the outer membrane. The domain is found in other Proteobacterial species apart from Vibrio.


:

Pssm-ID: 431425  Cd Length: 80  Bit Score: 87.72  E-value: 1.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501024745  292 QAWSAETGSTLRDTLEAWAKRARWTVRWEPQDlNYPIEAPLTFHGSFEDAVSELFPLYDAAERPFLVNASRPQSLIIIKE 371
Cdd:pfam10671   1 QTWSAVKGETLRDTLQRWASQAGWTVVWDADV-DYPVEASATFSGSFESAVRRVLSALANAGRPLKACFYSKNRVVRVTD 79


                  .
gi 501024745  372 R 372
Cdd:pfam10671  80 K 80
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
194-364 8.03e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 38.32  E-value: 8.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501024745 194 PSSTEKVSTLESPVVVASVPTPAPITTSPAPTKKPEYTTVLPPAAPAKDGHSSSPPAASAPIKLPASAVKSTPPTPATVA 273
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPA 455

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501024745 274 STPPDKALPSAEPSRPLTQAwsAETGSTLRDTLEAWAKRARWTVRWEPQDLNYPIEAPLTFHGSFEDAVSELFPLYDAAE 353
Cdd:PRK12323 456 AAPAAAARPAAAGPRPVAAA--AAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATAD 533

                        170
                 ....*....|.
gi 501024745 354 RPFLVNASRPQ 364
Cdd:PRK12323 534 PDDAFETLAPA 544
 
Name Accession Description Interval E-value
conj_PilL TIGR03748
conjugative transfer region protein, TIGR03748 family; This model describes the conserved ...
 55-159 4.37e-57

conjugative transfer region protein, TIGR03748 family; This model describes the conserved N-terminal region of a variable length protein family associated with laterally transfered regions flanked by markers of conjugative plasmid integration and/or transposition. Most members of the family have the lipoprotein signal peptide motif. A member of the family from a pathogenicity island in Salmonella enterica serovar Dublin strain was designated PilL for nomenclature consistency with a neighboring gene for the pilin structural protein PilS. However, the species distribution of this protein family tracks much better with markers of conjugal transfer than with markers of PilS-like pilin structure. [Mobile and extrachromosomal element functions, Plasmid functions]


Pssm-ID: 163460  Cd Length: 105  Bit Score: 181.31  E-value: 4.37e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501024745   55 VRYGRYTLVSTQPDAGQRDLMAQIIDVTIPSSMNPSVKDAMQYVMSRSGYSLCPAEAGHVNILYTRPLPAAQYKLGPMTL 134
Cdd:TIGR03748   1 VRYGRYTLVETRPEAAQRDLLNQVIDITIPPSLVATVGDALRYLLRRSGYSLCPASALSEAALLTLPLPAAHRKLGPMTL 80

                          90       100
                  ....*....|....*....|....*
gi 501024745  135 RNTLQVLSGPAWQVKVDEVARQVCF 159
Cdd:TIGR03748  81 RDALQVLAGPAWRLKVDDVTREVCF 105
TcpQ pfam10671
Toxin co-regulated pilus biosynthesis protein Q; The toxin-coregulated pilus (TCP) of Vibrio ...
 292-372 1.30e-21

Toxin co-regulated pilus biosynthesis protein Q; The toxin-coregulated pilus (TCP) of Vibrio cholerae and the soluble TcpF protein that is secreted via the TCP biogenesis apparatus are essential for intestinal colonization in the disease of cholera. TcpQ is part of an outer membrane complex of the TCP biogenesis apparatus, comprised of TcpC and TcpQ, and the TcpQ is required for proper localization of TcpC to the outer membrane. The domain is found in other Proteobacterial species apart from Vibrio.


Pssm-ID: 431425  Cd Length: 80  Bit Score: 87.72  E-value: 1.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501024745  292 QAWSAETGSTLRDTLEAWAKRARWTVRWEPQDlNYPIEAPLTFHGSFEDAVSELFPLYDAAERPFLVNASRPQSLIIIKE 371
Cdd:pfam10671   1 QTWSAVKGETLRDTLQRWASQAGWTVVWDADV-DYPVEASATFSGSFESAVRRVLSALANAGRPLKACFYSKNRVVRVTD 79


                  .
gi 501024745  372 R 372
Cdd:pfam10671  80 K 80
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
194-364 8.03e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 38.32  E-value: 8.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501024745 194 PSSTEKVSTLESPVVVASVPTPAPITTSPAPTKKPEYTTVLPPAAPAKDGHSSSPPAASAPIKLPASAVKSTPPTPATVA 273
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPA 455

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501024745 274 STPPDKALPSAEPSRPLTQAwsAETGSTLRDTLEAWAKRARWTVRWEPQDLNYPIEAPLTFHGSFEDAVSELFPLYDAAE 353
Cdd:PRK12323 456 AAPAAAARPAAAGPRPVAAA--AAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATAD 533

                        170
                 ....*....|.
gi 501024745 354 RPFLVNASRPQ 364
Cdd:PRK12323 534 PDDAFETLAPA 544
 
Name Accession Description Interval E-value
conj_PilL TIGR03748
conjugative transfer region protein, TIGR03748 family; This model describes the conserved ...
 55-159 4.37e-57

conjugative transfer region protein, TIGR03748 family; This model describes the conserved N-terminal region of a variable length protein family associated with laterally transfered regions flanked by markers of conjugative plasmid integration and/or transposition. Most members of the family have the lipoprotein signal peptide motif. A member of the family from a pathogenicity island in Salmonella enterica serovar Dublin strain was designated PilL for nomenclature consistency with a neighboring gene for the pilin structural protein PilS. However, the species distribution of this protein family tracks much better with markers of conjugal transfer than with markers of PilS-like pilin structure. [Mobile and extrachromosomal element functions, Plasmid functions]


Pssm-ID: 163460  Cd Length: 105  Bit Score: 181.31  E-value: 4.37e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501024745   55 VRYGRYTLVSTQPDAGQRDLMAQIIDVTIPSSMNPSVKDAMQYVMSRSGYSLCPAEAGHVNILYTRPLPAAQYKLGPMTL 134
Cdd:TIGR03748   1 VRYGRYTLVETRPEAAQRDLLNQVIDITIPPSLVATVGDALRYLLRRSGYSLCPASALSEAALLTLPLPAAHRKLGPMTL 80

                          90       100
                  ....*....|....*....|....*
gi 501024745  135 RNTLQVLSGPAWQVKVDEVARQVCF 159
Cdd:TIGR03748  81 RDALQVLAGPAWRLKVDDVTREVCF 105
TcpQ pfam10671
Toxin co-regulated pilus biosynthesis protein Q; The toxin-coregulated pilus (TCP) of Vibrio ...
 292-372 1.30e-21

Toxin co-regulated pilus biosynthesis protein Q; The toxin-coregulated pilus (TCP) of Vibrio cholerae and the soluble TcpF protein that is secreted via the TCP biogenesis apparatus are essential for intestinal colonization in the disease of cholera. TcpQ is part of an outer membrane complex of the TCP biogenesis apparatus, comprised of TcpC and TcpQ, and the TcpQ is required for proper localization of TcpC to the outer membrane. The domain is found in other Proteobacterial species apart from Vibrio.


Pssm-ID: 431425  Cd Length: 80  Bit Score: 87.72  E-value: 1.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501024745  292 QAWSAETGSTLRDTLEAWAKRARWTVRWEPQDlNYPIEAPLTFHGSFEDAVSELFPLYDAAERPFLVNASRPQSLIIIKE 371
Cdd:pfam10671   1 QTWSAVKGETLRDTLQRWASQAGWTVVWDADV-DYPVEASATFSGSFESAVRRVLSALANAGRPLKACFYSKNRVVRVTD 79


                  .
gi 501024745  372 R 372
Cdd:pfam10671  80 K 80
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
194-364 8.03e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 38.32  E-value: 8.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501024745 194 PSSTEKVSTLESPVVVASVPTPAPITTSPAPTKKPEYTTVLPPAAPAKDGHSSSPPAASAPIKLPASAVKSTPPTPATVA 273
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPA 455

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501024745 274 STPPDKALPSAEPSRPLTQAwsAETGSTLRDTLEAWAKRARWTVRWEPQDLNYPIEAPLTFHGSFEDAVSELFPLYDAAE 353
Cdd:PRK12323 456 AAPAAAARPAAAGPRPVAAA--AAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATAD 533

                        170
                 ....*....|.
gi 501024745 354 RPFLVNASRPQ 364
Cdd:PRK12323 534 PDDAFETLAPA 544
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH