|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
27-399 |
1.98e-99 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 300.63 E-value: 1.98e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 27 IGICHMLNDTLQAVIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAF 106
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 107 APSFATILLCVVFIGLGSAIFHPEGSRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAWFTIVGMI 186
Cdd:cd17478 81 APNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 187 AVGFLLYISRWYAGRLQTIRAQAKKAPAKaarselhRKSALTALGIIVFLIFARSWYGNAISNFYAFYAIeQYGLTIKES 266
Cdd:cd17478 161 AVALLLLRLRPLKKPEAKKAAAKSSARST-------LKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLV-QRGYSLVFA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 267 QTYIFLFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAGPVFAYVLLGLIGVILTSSFSVTVVYAQELFP 346
Cdd:cd17478 233 GLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLP 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 500857713 347 GKIGTMSGLTVGLAFGMGAIGSVALGSFIDTFGLTPTMIGVAFLPILGILAFL 399
Cdd:cd17478 313 GNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
23-400 |
5.66e-36 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 135.38 E-value: 5.66e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 23 ILLIIGICHMLNDTLQAVIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIF 102
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 103 GLAFAPSFATILLCVVFIGLGSAIFHPEGSR-VANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAWFT 181
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKlIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 182 IVGMIAVGFLLYIsrwyagrlqtiraqakkapakaarselhrksaltalgIIVFLIFARSWYGNAISNFYAFYAIEQYGL 261
Cdd:COG2271 171 GLPGLLLALLRFW-------------------------------------LLALAYFLVYFALYGFLTWLPTYLVEVRGL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 262 TIKESQTYIFLFLILGAIGTFLGGPLADRFGK--KTVILISLLASFPLALLLPFAG-PVFAYVLLGLIGVILTSSFSVTV 338
Cdd:COG2271 214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPsPALAIALLFLAGFGLGGAFGLLW 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500857713 339 VYAQELFPGKI-GTMSGLTVGLAFGMGAIGSVALGSFIDTFGLTPTMIGVAFLPILGILAFLL 400
Cdd:COG2271 294 ALAAELFPKKArGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
21-400 |
7.94e-28 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 113.44 E-value: 7.94e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 21 YPILLIIGICHMLNDTLQAVIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVG 100
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 101 IFGLAFAPSFATILLCVVFIGLGSAIFHPEGSRVANMAAGP-RRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAW 179
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 180 FTIVGMIAVGFLLYisrWYAGRLQTIRAQAKKAPAKAARSELHRKSALtalgIIVFLIFARSWYGNAISNFYAFYAIEQY 259
Cdd:COG2223 164 ILGILLLVVAVLAW---LFLRDPPAGAAAAAKASLRDQLEALRDPRFW----LLSLLYFGTFGSFIGFSSWLPPYLVDQF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 260 GLTIKESQTYIFLFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAGPVFAYVLLGLIGVILTSSFSVTVV 339
Cdd:COG2223 237 GLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAV 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500857713 340 YAQ--ELFPGK-IGTMSGLTVGLAFGMGAIGSVALGSFIDTFG-LTPTMIGVAFLPILGILAFLL 400
Cdd:COG2223 317 FALvpDIFPTKnAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLL 381
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-366 |
2.64e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 102.74 E-value: 2.64e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 14 SVTGSTVYPILLIIGICHMLNDTLQAVIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIA 93
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 94 LFSSAVGIFGLAFAPSFATILLCVVFIGLGSAIFHPEG-SRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPL 172
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAAlALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 173 GQPGVAWFTIVGMIAVGFLLYIsrwyagRLQTIRAQAKKAPAKAARSELHRKSALTALGIIVFLIFArswyGNAISNFYA 252
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLR------LLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFG----FFALFTYLP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 253 FYAIEQYGLTIKESQTYIFLFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAGPVFAYVLLG-LIGVILT 331
Cdd:COG2814 232 LYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALfLLGFGFG 311
|
330 340 350
....*....|....*....|....*....|....*.
gi 500857713 332 SSFSVTVVYAQELFPGKI-GTMSGLTVGLAFGMGAI 366
Cdd:COG2814 312 LLFPLLQALVAELAPPEArGRASGLYNSAFFLGGPL 347
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
23-400 |
1.64e-20 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 92.22 E-value: 1.64e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 23 ILLIIGICHMLNDTLQAVIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIF 102
Cdd:COG0738 9 ALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 103 GLAFAPSFATILLCVVFIGLGSAIF----HPEGSRVANMAAGPRRGLAQSIYQVGGntgqAFAPLIAALMLvpLGQPGVA 178
Cdd:COG0738 89 LFALAPSYPLLLLALFLLGLGLGLLdvaaNPYVAALGPETAASRLNLLHAFFSLGA----LLGPLLGGLLI--LLGLSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 179 WFTIVGMIAVGFLLYISRWYAGRLQTIRAQA-KKAPAKAARSELHRKSALTALGIIVFLIFArswYGNAISNFYAFYAIE 257
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLRSKLPEIEEEEeEAAGSAASLKSLLKNPRLLLGGLAIFLYVG---AEGAIGDWLPLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 258 QYGLTIKESQTYIFLFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFA-GPVFAYVLLGLIGVILTSSFSV 336
Cdd:COG0738 240 VLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLApGPWLALIGLALVGLGLSLMFPT 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500857713 337 TVVYAQELFPGKIGTMSGLTVGLAFGMGAIGSVALGSFIDTFGLTPTMIGVAFLPILGILAFLL 400
Cdd:COG0738 320 IFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
41-399 |
4.92e-19 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 88.06 E-value: 4.92e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 41 IPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATILLCVVFI 120
Cdd:cd17475 15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 121 GLGSAIFHPEGSRvANMAAGP--RRGLAQSIYQvggnTGQAFAPLIAALMLVPL-GQPGVAW-FTIVGMIAVGFLLYISR 196
Cdd:cd17475 95 GAGYGSVQPGGGR-AIMRWFPprERGLAMGIRQ----TGVPLGGALAAALLPPLaLHYGWRAaFVVAGLVSILAAVLFWL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 197 WYAGRLQTIRAQAKKAPAKAARSELHRKSALTALGIIVFLIFARSWygnAISNFYAFYAIEQYGLTIKESQTYIFLFLIL 276
Cdd:cd17475 170 FYREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQF---ALLTFLLLFLHDHLGLSVVAAGALLAVAQLG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 277 GAIGTFLGGPLADRFGK-------KTVILISLLASFPLALLLPFAGPVFAYVLLGLIGVILTSSFSVTVVYAQELFP-GK 348
Cdd:cd17475 247 GALGRIGLGRVSDRVFGgrrrpvlVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGpEQ 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 500857713 349 IGTMSGLTVGLAFGMGAIGSVALGSFID-TFGLTPTMIGVAFLPILGILAFL 399
Cdd:cd17475 327 AGTALGLANTINFIGIAIGPPLFGLLVDaTHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
27-399 |
8.10e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 87.48 E-value: 8.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 27 IGICHMLNDTLQAVIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAF 106
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 107 APSFATILLCVVFIGLGSAIFHPEGSR-VANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAWFTIVGM 185
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLAlIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 186 IAVGFLLYISRWYAGRLQTIRAQAKKAPAKAARSELHRKSALTALGIIVFLIFARSWYGNAISNFYAFYAIEQYGLTIKE 265
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 266 SQTYIFLFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAGPVF--AYVLLGLIGVILTSSFSVTVVYAQE 343
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLllLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 500857713 344 LFP-GKIGTMSGLTVGLAFGMGAIGSVALGSFID-TFGLTPTMIGVAFLPILGILAFL 399
Cdd:cd06174 321 LFPpEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
44-400 |
1.65e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 86.48 E-value: 1.65e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 44 MFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATILLCVVFIGLG 123
Cdd:cd17325 18 ILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 124 SAIFHPEG-SRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAWFTIVGMIAVGFLLYISRWYAGRL 202
Cdd:cd17325 98 SAAVWPAAmALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 203 QTIRAQAKKAPAKAARSELHRKSALTALGIIVFLIFARSwygnAISNFYAFYAIEQYGLTIKESQTYIFLFLILGAIGTF 282
Cdd:cd17325 178 PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFG----ALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQP 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 283 LGGPLADRFGKKTVILISLLASFPLALLLPFA-GPVFAYVLLGLIGVILTSSFSVTVVYAQELFP-GKIGTMSGLtVGLA 360
Cdd:cd17325 254 PAGKLSDRIGRKPLILIGLLLSAVALLLLPLAtSFWLLLLLLALLGLGLGLVFPATLALLADIVPpEGRGTAMGL-FNTA 332
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 500857713 361 FGMG-AIGSVALGSFIDTFGLTPTMIGVAFLPILGILAFLL 400
Cdd:cd17325 333 FSLGmVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-368 |
6.17e-17 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 81.31 E-value: 6.17e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 24 LLIIGICHMLNDTLqaVIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFG 103
Cdd:pfam07690 1 LFLAAFLAALGRSL--LGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 104 LAFAPSFATILLCVVFIGLGSAIFHPEGSR-VANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAWFTI 182
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALAlIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 183 VGMIAVGFLLYISRWYAGRLQTIRAQAKKAPAKAARSELHRKSALTALGIIVFLIFArswygNAISNFYAFYAIEQYGLT 262
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFA-----FFGLLTYLPLYQEVLGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 263 IKESQTYIFLFLILGAIGTFLGGPLADRFGKKTVILIS----LLASFPLALLLPFAGPVFAYVLLGLIGVILTSSFSVTV 338
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAllllILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALN 313
|
330 340 350
....*....|....*....|....*....|.
gi 500857713 339 VYAQELFP-GKIGTMSGLTVGLAFGMGAIGS 368
Cdd:pfam07690 314 ALVSDLAPkEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
40-399 |
4.75e-16 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 79.13 E-value: 4.75e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 40 VIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATILLCVVF 119
Cdd:cd17324 17 VIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 120 IGLGSAIFHPEGSRVA-NMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAWFTIVGMIAVGFLLyisrWY 198
Cdd:cd17324 97 AGLAHGGFWAIAAAYAaDLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLL----WR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 199 AGRLQTIRAQAKKAPAKAARSELHRKSALTALGIIVFLIFARSwygnAISNFYAFYAIEQYGLTIKESQTYIFLFLILGA 278
Cdd:cd17324 173 LLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFF----ALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 279 IGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAG-PVFAYVLLGLIGVILTSSFSVTVVYAQELFPGKIGTMSGLTV 357
Cdd:cd17324 249 VGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPsPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYL 328
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 500857713 358 GLAFGMGAIGSVALGSFIDTFGLTPTMIGVAFLPILGILAFL 399
Cdd:cd17324 329 AAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
39-407 |
1.17e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 77.99 E-value: 1.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 39 AVIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATILLCVV 118
Cdd:COG2807 35 TSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 119 FIGLGSAIFHPEGSRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLG-QPGVAWFTIVGMIAVGFLLYISRw 197
Cdd:COG2807 115 LIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGwRGALAVWALLALLALLLWLPLLR- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 198 yagrlQTIRAQAKKAPAKAARSELHRKSALTALgiIVFLIFARSWYGnAISNFYAFYAieQYGLTIKESQTYIFLFLILG 277
Cdd:COG2807 194 -----RRPAAAAAAPAAASLRSLWRSPLAWLLT--LFFGLQSLLYYA-VVAWLPPILR--DAGLSAATAGLLLSLFQLAG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 278 AIGTFLGGPLADRFGKKTVILISLLASFPLALL-LPFAGPVFAYVLLGLIGVILTSSFSVTVVYAQELF--PGKIGTMSG 354
Cdd:COG2807 264 IPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLgLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRArtPAEAAALSG 343
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 500857713 355 LTVGLAFGMGAIGSVALGSFIDTFG-LTPTMIGVAFLPILGILAFLLPSDQTIS 407
Cdd:COG2807 344 MAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVLMLVAGLLAGRPYVE 397
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
23-400 |
2.40e-15 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 76.84 E-value: 2.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 23 ILLIIGICHMLNDTLQAVIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIF 102
Cdd:cd17319 4 IIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 103 GLAFAPSFATILLCVVFIGLGSAIFHPEGSRVANMAAGPR-RGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVawFT 181
Cdd:cd17319 84 LTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWA--FI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 182 IVGMIAVGFLLYISRWYagrlqtiraqakkapakaarselhrksalTALGIIVFLIFARSWYGNAISNFYAFYAIEQYGL 261
Cdd:cd17319 162 IEGLLGLLLAVLWWFYL-----------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 262 TIKESQTYIFLFLILGAIGTFLGGPLADRFG----KKTVILISLLASFPLALLLPFAGPVFAYVLLGLIGVILTSSFSVT 337
Cdd:cd17319 213 SLKQVGLLAAIPFLAGAIGMILGGRLSDRLLrgarRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVF 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500857713 338 VVYAQELFPGK-IGTMSGLTVGLAFGMGAIGSVALGSFIDTFG-LTPTMIGVAFLPILGILAFLL 400
Cdd:cd17319 293 WSLPADLLPGEaAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
53-401 |
6.36e-13 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 69.64 E-value: 6.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 53 GLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATILLCVVFIGLGSAIFHPEGS 132
Cdd:cd17371 30 GLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 133 RVANMAAGPR-RGLAQSIYQVGGNTGQAFAPLIAALMLvPLGQPGVAWFT--IVGMIAVGFLLYISRWY---AGRLQTIR 206
Cdd:cd17371 110 ALMAEYVPARhRGKALGYVQSGWAVGWLLATLLAALLF-PLLPPEIAWRVlfLLGALPALLVLFIRRFVkepPQWQAARA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 207 AQAKKAPAKAARSELHRKSALTALGIIVFLIFARSWYgNAISNFYAFYAIEQYGLTIKESQTYIFLFLILGAIGTFLGGP 286
Cdd:cd17371 189 ARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGY-YGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGF 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 287 LADRFGKKTVILISLLASF---PLALLLPfAGPVFAYVLLGLIGVILTSSFSVTVVYAQELFPGKI-GTMSGLTVGLAFG 362
Cdd:cd17371 268 LADRIGRRNNFALFALGSAisiLLYFFLP-LSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVrATAQGFCYNVGRI 346
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 500857713 363 MGAIGSVALGSFIDTFGLTPTMIGVAFLP--ILGILAFLLP 401
Cdd:cd17371 347 IGALFPFLVGFLATSGSLGTAIAVFAAVYyiAGLVLALLLP 387
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
38-399 |
3.65e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 64.54 E-value: 3.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 38 QAVIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDK------RPMPYALpIALFSSAVGIFGLAFAPSFA 111
Cdd:COG2211 27 GLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRtrtrwgRRRPWIL-IGAIPLALSFVLLFTAPDLS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 112 T----ILLCVVFIGLG---SAIFHPEGSRVANMAAGPR-RGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAWFTIV 183
Cdd:COG2211 106 PtgklIYALVTYLLLGlayTLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLT 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 184 GMI--AVGFLLYISRWYAGRLQTIRAQAKKAPAKAARSELHRKSALTALGIIVFLIFArswyGNAISNFYAFYAIEQYGL 261
Cdd:COG2211 186 ALIfaVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLA----LALVAALLLYYFKYVLGL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 262 TIKESQTYIFLFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAGP---VFAYVLLGLIGVILTSSFSVT- 337
Cdd:COG2211 262 SAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPgnlWLLLVLAALAGIGLGAILVLPw 341
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500857713 338 -----VVYAQELFPGKIGT---MSGLTVGLAFGMgAIGSVALGSFIDTFGLTP---------TMIGVAFLPILGILAFL 399
Cdd:COG2211 342 amladVVDYDEWKTGRRREglyFGIFTFAIKLGQ-ALAGALAGLLLALFGYVAgaaqspsalTGIRLLFFLLPAVLLLL 419
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
61-398 |
4.32e-11 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 64.24 E-value: 4.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 61 LIAFTLNMVSSVMQPA----IGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATI--------LLCVVFIGLGSAIFH 128
Cdd:cd17367 40 LSTAAVFAVGFLMRPIggwlFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATIgiwapiilLLARLLQGLSVGGEY 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 129 PEGSRVANMAAGP-RRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGV---AW---FTIVGMIAVgFLLYISRWYAGR 201
Cdd:cd17367 120 GTSATYLSEVAPPgRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLGEDQMaawGWripFLLGGVLAV-VVLWLRRGLEET 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 202 LQTIRAQAKKAPAKAARSEL--HRKSALTALGIIvflifarswyGNAISNFYAF------YAIEQYGLTIKESQTYIFLF 273
Cdd:cd17367 199 ESFEAIAESNEASAGTLRELrrHPRELLLVVGLT----------AGGTLAFYTWttylqkFLVNTAGFSKGDATWITTAA 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 274 LILGAIGTFLGGPLADRFGKKTVILIS----LLASFPLALLLPFA-GPVFAYVLLGLIGVILTSSFSVTVVYAQELFPGK 348
Cdd:cd17367 269 LLVFMLLQPLGGRLSDRIGRRPLLLFFgiggTLATVPLLSALDHTdSPYTAFALVLVGLVFLSGYTSINAVVKAELFPTH 348
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 500857713 349 IGTmsgLTVGLAFGMgaigSVALgsfidtFGLTPTMIGVAFLPILGILAF 398
Cdd:cd17367 349 VRA---LGVGLPYAL----AVAI------FGGTAPYVALWLKSIGHEWVF 385
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
46-383 |
5.28e-11 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 63.55 E-value: 5.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 46 PILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATILLCVVFIGLGSA 125
Cdd:TIGR00881 19 PYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 126 I-FHPEGSRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQpGVAWFTIVGMIAVGFLLYISRWYAGRLQT 204
Cdd:TIGR00881 99 MgWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYS-WHWVFIVPGIIAIIVSLICFLLLRDSPQS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 205 --IRAQAKKAPAKAARSELHRKSALTALGIIV-FLIFARSWYGNAISNFYAF------------YAIEQYGLTIKESQTY 269
Cdd:TIGR00881 178 cgLPPAEEMPNEEPDGDAEKKEEELTKKQIFLqYVLLNKVLWYISLGYVFVYvvrtgildwsplYLTQEKGFSKEKASWA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 270 IFLFLILGAIGTFLGGPLADRF--GKKTVILISLLASFPLALLL----PFAGPVFAYVLLGLIGVILTSSFSVTVVYAQE 343
Cdd:TIGR00881 258 FTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVywlnPAANPLMDLICLFALGFLVYGPQMLIGVIASE 337
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 500857713 344 LFPGK-IGTMSGLTVGLAFGMGAIGSVALGSFIDTFGLTPT 383
Cdd:TIGR00881 338 LAPKKaAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGA 378
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
78-400 |
2.33e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 61.46 E-value: 2.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 78 GWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATILLCVVFIGLGSAIFHPEG-SRVANMAAGPRRGLAQSIYQVGGNT 156
Cdd:cd17316 57 GYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGAsTYVAEFAPSKRRGFALGLLQSGWAL 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 157 GQAFAPLIAALmLVPLGQPGVAW--FTIVGMIAVGFLLYISRWyagrlqtiraqakkapakaarselhrksalTALGIIV 234
Cdd:cd17316 137 GALLAALVASL-LIPLLSGDWGWriLFLIGALPALLALLLRRR------------------------------TLLLILL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 235 FLIFARSWYGnaISNFYAFYAIEQYGLTIKESQTYIFLFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFA 314
Cdd:cd17316 186 WFFISFGYYG--LTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 315 GPVFAYVLLG---LIGVILTSSFSVTVVYAQELFPGKI-GTMSGLTVGLAFGMGAIGSVALGSFIDTFGLTPTMIGVAFL 390
Cdd:cd17316 264 LSGSPTLLLLllfILSFFVGGVWGALYAYLAELFPTEVrATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILAL 343
|
330
....*....|
gi 500857713 391 PILGILAFLL 400
Cdd:cd17316 344 LAIVALIVAL 353
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
23-400 |
8.65e-10 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 59.93 E-value: 8.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 23 ILLIIGICHMLNDTLQAVIPAMFPILERSMGLTFTQLGLiAFTLNMVS-SVMQPAIGWYTDKRPMPYALPIALFSSAVGI 101
Cdd:cd17353 4 LVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVAL-AFTLTIVFlAISAPFAGRLVDRGGPRKAILIGGILFGLGF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 102 FGLAFAPSFATILLCV-VFIGLGSAIFHPEGSRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQP----- 175
Cdd:cd17353 83 ILSAFAISLPLLFLGYgVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPttfli 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 176 -GVAWFTIVGMIAVGFLLYISRWYAGRLQTIRAQAKKAPAKAARSELHRKSALTALGIIVFLIFArswYGNAISNFYAFY 254
Cdd:cd17353 163 lGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNAT---AGLMLIGQAKPI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 255 AIEQYGLTIKESQTYIFLFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAGPVFAYVLLGLIGVILT--S 332
Cdd:cd17353 240 GQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCygG 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 333 SFSVTVVYAQELFPGK-IGTMSGLtVGLAFGMGA-IGSVALGSFIDTFGLTPTMIGVAFLPILGILAFLL 400
Cdd:cd17353 320 GFALFPALTADFFGTKnAGTNYGL-LYTAKGVGGlIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALL 388
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
46-400 |
1.16e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.53 E-value: 1.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 46 PILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATILLCVVFIGLGSA 125
Cdd:cd17489 20 PLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 126 IFHPEGSRVANMAAGP-RRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAWFTIVgMIAVGFLLYISRWYAgrlqT 204
Cdd:cd17489 100 AFTTAAATLVADIIPPsRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAV-LALLALLLVFLVKDP----P 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 205 IRAQAKKAPAKAARSELHRKSALTALGIIVFLIFARSwygnAISNFYAFYAIEQygltikeSQTYIFLFLILGAIGTFLG 284
Cdd:cd17489 175 PVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYG----AISTFLPLYAAER-------GISNAGLFFTVYAIALLLS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 285 GP----LADRFGKKTVILISLLAsFPLALLLPFAGPVFAYVLLG--LIGVILTSSFSVTVVYA-QELFPGKIGT-MSGLT 356
Cdd:cd17489 244 RPfsgkLSDRKGPKTVIIPGLLL-LALGLLLLSFAGSPWMLLLAavLYGLGFGLLFPALQALAvDLVPPHRRGAaNGTFF 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 500857713 357 VGLAFGMGaIGSVALGSFIDTFGLTPTMIGVAFLPILGILAFLL 400
Cdd:cd17489 323 IFFDLGIG-LGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
41-400 |
3.49e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 58.03 E-value: 3.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 41 IPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFA-PSFATILLCVVF 119
Cdd:cd17341 18 FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAvSSYWGLLVLGFL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 120 IGLGSAIFHPEGSRVANMAAGPRRGLAQSIYQVGGNTG----QAFAPLIAALMLVPLGQPG---VAWFTIVGMIAVGFLL 192
Cdd:cd17341 98 LGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGvavsQLLAPLIAGAIVFDGGFVGwrnAFFVPGILLAIAAVLV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 193 YISRWYAGrlQTIRAQAKKAPAKAARSELHRKSALTALGIIVFLIFArswygnAISNFYAFYAIEQYGLTIKESQTYIFL 272
Cdd:cd17341 178 LLFGDDLP--TGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFV------GFSNVLPTYFKTRFGLPLVTAGILAAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 273 FLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAGPVFAYVLLGLIGVILtsSFSVTVVYAQELFPGKIGTM 352
Cdd:cd17341 250 FPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFV--ALGLGAGAGNGSVFRMVPFI 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 500857713 353 SGLTVGLAFGM-GAIGsvALGSFI--DTFGLTPTMIGVAFLPILGILAFLL 400
Cdd:cd17341 328 FRRELGAVTGLvGAIG--GLGGFFlpLLFGSSALMTGSGVGAFSLFGVLAV 376
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
25-399 |
3.76e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 57.94 E-value: 3.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 25 LIIGICHMLNDTLQAVIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDK---RPMPYALPIALfsSAVGI 101
Cdd:cd17370 2 WLLGLVSLFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRtgkRKPLVILGYGL--SALAK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 102 FGLAFAPSFATILLCVVFIGLGSAIFHPegSR---VANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLG---QP 175
Cdd:cd17370 80 PLLALAGSWQLVLLLRILERLGKGIRTP--PRdalLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGgnyRT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 176 GVAWFTIVGMIAVGFLLYIsrwyagRLQTIRAQAKKAPAKAARSELHRKSALTALGIIVFLIFARSwygnaisnFYAFYA 255
Cdd:cd17370 158 IFLLAAIPALLALLILLFV------VKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNF--------SFAFLI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 256 IEQYGLTIKESQTYIF--LFLILGAIGTFLGGPLADRFGKKTVILISLLAS-FPLALLLPFAGPVFAYVLLGLIGVILTS 332
Cdd:cd17370 224 LRAQELGLSAALIPLLyaLFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLaLAYLGFALGSSLWLLLLGFILWGLYMGA 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500857713 333 SFSVTVVYAQELFPGKI-GTMSGLtVGLAFGMGA-IGSVALGSFIDTFGLTPTMIGVAFLPILGILAFL 399
Cdd:cd17370 304 QESIERAAVADLVPAELrGTAYGL-FNTVVGIGWlLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
39-400 |
8.01e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 56.85 E-value: 8.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 39 AVIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATILLCVV 118
Cdd:cd17329 17 MVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 119 FIGLGSAIFHPEGSR-VANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVpLGQPGVAWFTIVGMIAVGFLLYIsrW 197
Cdd:cd17329 97 LTGFGGGLFEPASEAmIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLF--L 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 198 YAGRLQTIRAQAKKAPAKAARSELHRKSALTALGIIVFLIFArswyGNAISNFYAFYAIEQYGLTIKESQTYIFLFLILG 277
Cdd:cd17329 174 LPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLI----YFQLESTLPVYVVEILGLGESLLGLLLALNALLI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 278 AIGTFLGGPLADRFGKKTVILISLL---ASFPLALLLPFAGPVFAYVLLGLIGVILTSSFSVTVVyAQELFPGKIGTMSG 354
Cdd:cd17329 250 VLLQFPVARLVERFRLRKILMIGILlfaIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLV-AALAPPDKRGSYMG 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 500857713 355 LtVGLAFGMG-AIGSVALGSFIDTFGLTPTMIGVAFLPILGILAFLL 400
Cdd:cd17329 329 F-YALAWGLGrAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLG 374
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
38-398 |
2.01e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 55.64 E-value: 2.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 38 QAVIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATILLCV 117
Cdd:cd17477 12 SGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 118 VFIGLGSAIFHPEGSRVANMAAGPR-RGLAQSIYQVGGNTGQAFAPLIAALMlvplGQPGVAWFTIVG-MIAVGFLLYIS 195
Cdd:cd17477 92 FVMGIGLAGLFVVSESWLNALATNEnRGRVLGLYSTVLGLGFALGPLLLALV----GTAGALPFLIAAvLLLLALVPLLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 196 RWYAGRLQTiraqakkapakaARSELHRKSALTALGIIVFLIFARSWYGNAISNFYAFYAIEQyGLTIKESQTYIFLFLI 275
Cdd:cd17477 168 TRRAAPEIE------------EAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRL-GLSVAQAALLLAAFVL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 276 LGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAG--PVFAYVLLGLIGVILTSSFSVTVVYAQELFPGK--IGT 351
Cdd:cd17477 235 GGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPglPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDelVAA 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 500857713 352 MSGLTVGLAFGmGAIGSVALGSFIDTFGLTPTMIGVAFLPILGILAF 398
Cdd:cd17477 315 NAALLLLYGLG-SVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
20-400 |
4.83e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 54.63 E-value: 4.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 20 VYPILLIIGICHMLNDTLQAVIPAMFPILERSMGLTFT--QLGLIAFTLNMvssvmqpaiGWYTDKRPMPYALPIALFSS 97
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSsqNAGYLIGSLLA---------GFLMKRLGRRRTLILGLLLI 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 98 AVGIFGLAFAPSFATILLCVVFIGLGSAIFHPEGSRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGV 177
Cdd:cd17333 72 SLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 178 AWFTIVG-MIAVGFLLYISRWYAGRLQTIRAQAKKAPAKAARSELHRKSALTAlgiiVFLIFARSWYGNAISNFYAFYAI 256
Cdd:cd17333 152 AYLIIGLiYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILG----ALALFLYVGAETAFSSWVPSYLV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 257 EQYGLTIKESQTYIFLFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFA-GPVFAYVLLGLIGVILTSSFS 335
Cdd:cd17333 228 EKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLApTLVVGLVATALLGLFMAALFP 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500857713 336 VTVVYAQELFPGKIGTMSGLTVGLAFGMGAIGSVALGSFIDTFGLTPTMIgvaFLPILGILAFLL 400
Cdd:cd17333 308 TILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAML---LITILYAIIFVL 369
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
72-400 |
6.46e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.16 E-value: 6.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 72 VMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAP-----SFATILLCVVFIGLGSAIFHP-EGSRVANMAAGPRRGL 145
Cdd:cd06173 49 LFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGIASAFFGPaRQALLPELVPKEQLVR 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 146 AQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAWFTIVGMIAVGFLLYISRWYAGRLQTIRAQAKKAPAKAARSELHRKS 225
Cdd:cd06173 129 ANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 226 ALTALGIIVFLIFArswYGNAISNFYAFYAIEQYGLTIKESQTYIFLFLILGAIGTFLGGPLADRFGKKTVILISLLASF 305
Cdd:cd06173 209 LLRLLLLALALFAL---LGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLG 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 306 PLALLLPFAGPVF-AYVLLGLIGVILTSSFSVTVVYAQELFPGKI-GTMSGLTVGLAFGMGAIGSVALGSFIDTFGLTPT 383
Cdd:cd06173 286 LALLVLGLSPSLWlLLAALFLLGLAGGLFNVPLNTLLQLRVPDELrGRVFSVYNALNSGAMPLGALLAGLLADALGLSAV 365
|
330
....*....|....*..
gi 500857713 384 MIGVAFLPILGILAFLL 400
Cdd:cd06173 366 FLLAGALLLLAALLLLL 382
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
18-196 |
1.13e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 53.35 E-value: 1.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 18 STVYPILLIIGICHMLNDTLQAVIPAMfpiLERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSS 97
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLY---AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 98 AVGIFGLAFAPSFATILLCVVFIGLGSAIFHP-EGSRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPG 176
Cdd:cd17325 276 AVALLLLPLATSFWLLLLLLALLGLGLGLVFPaTLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAT 355
|
170 180
....*....|....*....|
gi 500857713 177 VAWFTIVGMIAVGFLLYISR 196
Cdd:cd17325 356 PFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
38-399 |
1.41e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 52.96 E-value: 1.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 38 QAVIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATILLCV 117
Cdd:cd17474 15 VSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 118 VFIGLGSAIFHP-EGSRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALmLVPLGQPGVAWFTIVGMIAvgFLLYISR 196
Cdd:cd17474 95 ALQGIGAAGLGPlALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGL-LAAISWRYPFFLLAALIPV--AFLAILF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 197 WYAGRLQTIRAQAKKAPAKAARSELHRKSALTALGIIVFLIFarswYGnAISNFYAFYAIEQYGLTIKESQTYIFLFLIL 276
Cdd:cd17474 172 LLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFL----YF-AFLTYLPFLLELLYGISPIIIGLLFAGWSVL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 277 GAIGTFLGGP-LADRFGKKTVILISLLA-SFPLALLLPFAGPVFAYVLLGLIGVILTSSFSVTVVYAQELFPGKI-GTMS 353
Cdd:cd17474 247 LALGSLFVGRlLKKRFGARRILVIGLLLyALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEErGTAS 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 500857713 354 GLTVGLAFGMGAIGSVALGSFIDTFGLTPT--MIGVAFLPILGILAFL 399
Cdd:cd17474 327 SLYNFVRFLGQAVGPLLFGLLLEIFGLSAPflVGAAIALAAAVLLALL 374
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
22-331 |
4.04e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 51.85 E-value: 4.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 22 PILLIIGICHMLNDTLqavIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGI 101
Cdd:cd17328 2 AVLFLINLLNYMDRFT---IAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAAT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 102 FGLAFAPSFATILLCVVFIGLGSAIFHP-EGSRVANMAAGPRRGLAQSIYQ------------VGGNTGQAFAPLIAALM 168
Cdd:cd17328 79 LLSSFAPNFWQLLLFRALVGIGEASYSPiAPTIIADLFPKEKRTRALGVFYfaiplgsglgyvVGGLVAQATGGWRWAFR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 169 LVPLgqpgvawFTIVGMIAVGFLLYISRWYAGRLQTIRAQAKKAPAKAARSELHRKSaltaLGIIVFLIFARSWYGNAIS 248
Cdd:cd17328 159 VTGV-------LGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPS----FILSTLGFTAVSFVTGALA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 249 NFYAFYAIEQYGLTIKESQTYIFLFLIL----GAIGTFLGGPLADRFGKKT------VILISLLASFPLALLLPFAGPVF 318
Cdd:cd17328 228 FWAPTFFLRAFGVGDLSSADVGLIFGAItciaGVLGVLLGGILADRLRRKTpradplVCAVGLLAAAPFLFLALVLALSN 307
|
330
....*....|...
gi 500857713 319 AYVLLGLIGVILT 331
Cdd:cd17328 308 LLLAWVLLFLGEF 320
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
39-400 |
4.82e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 51.43 E-value: 4.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 39 AVIPAMFPILERSMGLTFTQLGLIaFTLNMVS-SVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATILLCV 117
Cdd:cd17365 16 AVMGFVAPALAQDWGLSPAQLGPV-GSAALFGmAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 118 VFIGLG-SAIFHPEGSRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAWftiVGMIAVGFLLyisr 196
Cdd:cd17365 95 FLTGLGlGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFL---LGGVPPLILL---- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 197 wyagrlqtiraqakkapakaarsELHRKSALTALGIIVFLIfarSWYGnaiSNFYAFYAIEQYGLTIKESQTYIFLFLIL 276
Cdd:cd17365 168 -----------------------PLLRGTLLLWVTFFMGLL---LVYL---LNSWLPKLMVEAGYSLSQALTITLLLNIG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 277 GAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPF--AGPVFAYVLLGLIGVILTSSFSVTVVYAQELFPGKIgtmSG 354
Cdd:cd17365 219 GVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVspASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEV---RA 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 500857713 355 LTVGLAFGMGAIGSVA---LGSFIDTFGLTPTMIGVAFLP--ILGILAFLL 400
Cdd:cd17365 296 TGVGWALGVGRLGAILgplLGGLLLAAGLGPESVFLALAIpaALGALAVLL 346
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
272-377 |
1.25e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 49.89 E-value: 1.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 272 LFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAG--PVFAyVLLGLIGVILTSSFSVTVVYAQELFPGKI 349
Cdd:cd17317 33 IFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPsyELFL-VLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100
....*....|....*....|....*...
gi 500857713 350 GTMSGLTVGLAFGMGAIGSVALGSFIDT 377
Cdd:cd17317 112 RSFVGILFGLFWALGYMLLALLAYLIRD 139
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
52-399 |
1.72e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 49.85 E-value: 1.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 52 MGLTFTQLGLIaFTLNMVSSVM-QPAIGWYTDKRPM-PYALPIALFSSAVGIFGLAFAPSFATILLC-VVFIGLGSAIFh 128
Cdd:cd17471 27 LGASPLQIGIF-MTLSALSGIVvSQWLGRLSDRGGDrKPLILLALLAGALGYLLFAFLRNYWVLLLVgVVLLSLGAAAF- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 129 PE----GSRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAWFTIVGMIAVGFLLYIsrwyagRLQT 204
Cdd:cd17471 105 PQlfalAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLF------LLPS 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 205 IRAQAKKAPAKAARSELHRKSALTALGIIVFLIFARSW-YGNAISnfyaFYAIEQYGLTIkesqTYIFLFLILGAI---- 279
Cdd:cd17471 179 VKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSmYIIAMP----LYVTNELGGSE----SWVGLLFGLAAAleip 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 280 GTFLGGPLADRFGKKTVILISLLASFPLALLLPFAGPVFAYVLLGLI-GVILTSSFSVTVVYAQELFPGKIGTMSGL-TV 357
Cdd:cd17471 251 IMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLnAIFIGITAGLGISYFQDLMPGQPGLATTLySN 330
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 500857713 358 GLAFGMgAIGSVALGSFIDTFGLTPTMIGVAFLPILGILAFL 399
Cdd:cd17471 331 ASRIGS-LLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
53-336 |
4.11e-06 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 48.46 E-value: 4.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 53 GLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPY--ALPIALFS---SAVGIFGLAFAPSFAT----ILLCVVFIGLG 123
Cdd:pfam13347 29 GLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWgrRRPWLLLSaiiLAVSFILLFTPPELGRaplfIWLLATYILLR 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 124 SAI---FHPEGSRVANMAAGPR-RGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAWFTIVGMIAVGFLLYISRWYA 199
Cdd:pfam13347 109 IAYtffEIPYWSLGPELTRDYDeRTSLTSYRSFFSVGGGLLAAALAFPLVLILGGTGLERKGYRIFALIGAVLMLLGVII 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 200 GRLQTIRAQAKKAPAKAARSE----------LHRKSALTALGIIVFLIFARSWYGNAISNFYAFYAIEQYGltikESQTY 269
Cdd:pfam13347 189 TAAGTKERVSMRSKEDTGQKEagslldmlkeVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGF----AASAF 264
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 270 IFLFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAGP---VFAYVLLGLIGVILTSSFSV 336
Cdd:pfam13347 265 PLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPnntLLFLVLYIIIGFGYGSSFFL 334
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
23-196 |
4.42e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 48.38 E-value: 4.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 23 ILLIIGICHMLNDTLQAVIPAMfpiLERSMGLTFTQLGLIaFTLN-MVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGI 101
Cdd:cd17329 205 FLLASFLISLIYFQLESTLPVY---VVEILGLGESLLGLL-LALNaLLIVLLQFPVARLVERFRLRKILMIGILLFAIGF 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 102 FGLAFAPSFATILLCVVFIGLGSAIFHP-EGSRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAAlMLVPLGQPGVAWF 180
Cdd:cd17329 281 AVLAFANTLAVLILAMIVLTLGEMLVFPaVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGG-LLLDLLGPGLPWL 359
|
170
....*....|....*.
gi 500857713 181 TIVGMIAVGFLLYISR 196
Cdd:cd17329 360 ILAALGLIAAALLLGL 375
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
2-194 |
4.86e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 48.34 E-value: 4.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 2 AIAARTKDKPQNSVTGSTVYPILLIIGICHMLNDTLQAVIPAMFPILERSMGLTF-TQLGLIAFTLNMVSSVMQPAIGWY 80
Cdd:cd17473 177 ARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSaALIGLALAIASLAGAIGALLFGRL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 81 TDKRPMPYALPIALFSSAVGIFGLAFAPSFATILLCVVFIGLGSAIFHPEGSRVANMAAGPR-RGLAQSIYQVGGNTGQA 159
Cdd:cd17473 257 KRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPElRGRAMGIVTSAFFLGQF 336
|
170 180 190
....*....|....*....|....*....|....*
gi 500857713 160 FAPLIAALMLVPLGQPGVAWFTIVGMIAVGFLLYI 194
Cdd:cd17473 337 LSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
245-400 |
8.03e-06 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 47.84 E-value: 8.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 245 NAISNFYAFYAIEQYGLTIKESQTYIFLFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAGPVFAYVLLG 324
Cdd:COG2270 255 QTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILG 334
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500857713 325 -LIGVILTSSFSVT-VVYAQELFPGKIGTMSGLtvglaFGMGAIGSVALGSFIdtFGLTPTMIGVAFLPILGILAFLL 400
Cdd:COG2270 335 lLIGLVMGGIQALSrSLLARLIPPGREAEFFGL-----YALSGKAASFLGPLL--FGLVTQLTGSQRLGILSLIVFFV 405
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
75-337 |
8.89e-06 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 47.60 E-value: 8.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 75 PAIGWYTDKRPMPY----------ALPIALFSSAVgIFGLAFAPSFATILLCVVFIGLG---SAIFHPEGSRVANMAAGP 141
Cdd:cd17332 53 PLMGYLIDRTRSRWgrfrpwllwgAIPLALLFVLL-FTTPDGSGTGKLIYALITYILLDllyTLVNIPYTALIPELTDDP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 142 R-----RGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAWFTIVGMIAVGFLLYISRW--YAGRLQTIRAQAKKAPA 214
Cdd:cd17332 132 EertslTSWRMFFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFgtRERVVPPEEEKSKLPLL 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 215 KAARSELHRKSALTALGIIVFlifarSWYGNAISNFYAFYAIEQYGLTIKESQTYIFLFLILGAIGTFLGGPLADRFGKK 294
Cdd:cd17332 212 KSLKALLKNRPFLILLLAYLL-----YFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKK 286
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 500857713 295 TVILISLLASFPLALLLPFAGP---VFAYVLLGLIGVILTSSFSVT 337
Cdd:cd17332 287 KAFFIGLLLAILGLLLLFFLPPgnlVLILVLAVLAGIGYGGANLLP 332
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
20-194 |
1.91e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.43 E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 20 VYPILLIIGICHMLNDTLQAVIPAMFPILERSMGLTFTQLGLIAFTLNMVssVMQPAIGWYTDKRPMPYALPIALFSSAV 99
Cdd:cd17489 192 VEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAIALL--LSRPFSGKLSDRKGPKTVIIPGLLLLAL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 100 GIFGLAFAPSFATILLCVVFIGLGSAIFHPEGSRVANMAAGP-RRGLAQSIYQVGGNTGQAFAPLIAAlMLVPLGQPGVA 178
Cdd:cd17489 270 GLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPhRRGAANGTFFIFFDLGIGLGGLLLG-LVAELFGYRAM 348
|
170
....*....|....*.
gi 500857713 179 WFTIVGMIAVGFLLYI 194
Cdd:cd17489 349 FLLAAVVVLLALVLYI 364
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
61-370 |
3.04e-05 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 45.83 E-value: 3.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 61 LIAFTLNMVSSVMQP----AIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATI----LLCVVFIGL--GSAI---F 127
Cdd:cd17368 40 LLTFATFGVGFFMRPigaiVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATIgiaaPLLVLLARLlqGFAAggeV 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 128 HPEGSRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAWFT-----IVGMIAVGFLLYISRWYAGRL 202
Cdd:cd17368 120 GGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSLTLTAEALAEWGwripfFIGLLIIPLGLWLRRSLEETE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 203 QTIRAQAKKAPAKAARSELHRKSALTaLGIIVFLIFARSWYgnaISNFY-AFYAIEQYGLTIKESQTYIFLFLILGAIGT 281
Cdd:cd17368 200 AFLERKARPTRRELFALLANNRRIIL-LGMLLVAGSTVTFY---FTTVYtPTYAKTVLGLSARDSFLVTLLAGVANFIWA 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 282 FLGGPLADRFGKKTVILISLLASFPL---ALLLPFAGPVFAYVL--LGLIGVILTSSFSVTVVYAQELFPGKIGTmSGLT 356
Cdd:cd17368 276 PLGGALSDRIGRRPVLLVITLAALVTlypVFAWLTAAPSFGRLLlvLLVLSFFFGMYGGAMVVALVELFPVRVRS-TGFS 354
|
330
....*....|....
gi 500857713 357 VGLAFGMGAIGSVA 370
Cdd:cd17368 355 LVYALAVAIFGGFA 368
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
233-412 |
3.14e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.49 E-value: 3.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 233 IVFLIFARSWYGNAISNFYAFYAIEQYGLTIKESQTYIFLFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLP 312
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 313 FAGPVFAYVLLG-LIGVILTSSFSVTVVYAQELFPGKIGTMSGLTVGLAFGMG-AIGSVALGSFIDTFGLTPTMIGVAFL 390
Cdd:pfam07690 81 FASSLWLLLVLRvLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGaALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180
....*....|....*....|..
gi 500857713 391 PILGILAFLLPSDQTISKWNES 412
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKP 182
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
63-400 |
4.51e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 45.34 E-value: 4.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 63 AFTLNM-VSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFA--TILLCVVFIGLGSAIFHPEGSRVANMAA 139
Cdd:cd17355 43 AFTVGLlAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWqlYLLWGLLGGGGAGTLAAVAFATVAAWWF 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 140 GPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLG-QPGVAWFTIV-GMIAVGFLLYISRWYAGRLQTIRAQAKKAPAKAA 217
Cdd:cd17355 123 ERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGwRTALLVLALLaLLVLVPVLLLLRRRPADLALRAYDDASPASPGST 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 218 RSELHRKSALTALGIIVFLIFArswYGNAISNFYAFYAIEQyGLTIKESQTYIFLFLILGAIGTFLGGPLADRFGKKTVI 297
Cdd:cd17355 203 LKEALRSASFWLLALAFFLCGF---AVVGLIVHLVPYLADR-GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 298 LISLLAS--FPLALLLPFAGPVFAYVLLGLIGVILTSSFSVTVVYAQELFPGK-IGTMSGLTVGLAFGMGAIGSVALGSF 374
Cdd:cd17355 279 AASYALRalGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARsYGTLFGLVFAPHQLGSALGPWLGGLL 358
|
330 340
....*....|....*....|....*.
gi 500857713 375 IDTFGLTPTMIGVAFLpiLGILAFLL 400
Cdd:cd17355 359 YDRTGSYTAAWALAVA--LGLIAALL 382
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
77-369 |
8.05e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 44.65 E-value: 8.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 77 IGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATILLCVVFIGLGSAIFHPEGSRVANMAAGPR-RGLAQSIYQVGGN 155
Cdd:TIGR00895 72 FGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRfRGTAVGLMFCGYP 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 156 TGQAFAPLIAALMLVPLGQPGVawFTIVGMIAVGFLLYISRW------YAG--RLQTIRAQAKKAPAKAARSELH----R 223
Cdd:TIGR00895 152 IGAAVGGFLAGWLIPVFGWRSL--FYVGGIAPLLLLLLLMRFlpesidFLVskRPETVRRIVNAIAPQMQAEAQSalpeQ 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 224 KSALTALGIIVFLIFARS--------WYGNAISNFYAFYA-------IEQYGLTIKESQTYIFLFLILGAIGTFLGGPLA 288
Cdd:TIGR00895 230 KSTQGTKRSVFKALFQGKtaritvllWLLYFMLLVGVYFLtnwlpklMVELGFSLSLAATGGALFNFGGVIGSIIFGWLA 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 289 DRFGKKTVILISLLAS-FPLALLLPFAGPVFAYVLLGLIGVILTSSFSVTVVYAQELFPGKIgtmSGLTVGLAFGMGAIG 367
Cdd:TIGR00895 310 DRLGPRVTALLLLLGAvFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAI---RATGVGWAIGIGRLG 386
|
..
gi 500857713 368 SV 369
Cdd:TIGR00895 387 AI 388
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
273-393 |
9.98e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 44.17 E-value: 9.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 273 FLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAGPVFAYVLLG----LIGVILTSSFSVTVVYAQELFP-- 346
Cdd:cd17357 58 FFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKSPELLIfgrfLVGIACGLSTGFVPMYLQEISPse 137
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 500857713 347 --GKIGTMSGL------TVGLAFGM-GAIGSVALGSFIDTFGLTPTMIGVAFLPIL 393
Cdd:cd17357 138 lrGALGSLTQIgvtlgiLLGQVFGLpSVLGTETLWPYLLFFPGIPALLQLAALPFF 193
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
38-400 |
1.12e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 43.80 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 38 QAVIPAMFPILErSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATILLCV 117
Cdd:cd17312 20 KNFSVAKPPIVE-EIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 118 VFIGL-GSAIFHPEGSRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAWFTIVGMIAVGFLLYIsr 196
Cdd:cd17312 99 GLNGLfQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFF-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 197 wyagrlqTIRaqakkapakaarselHRKSALTALGI-IVFLIFARSwygnAISNFYAFYAIEQYGLTIKESQTYIFLFLI 275
Cdd:cd17312 177 -------FLR---------------DSPPYVWVLSLaYAFVYIVRY----ACLDWGPLYLYEVKGYSLIDAGWFSSLYEV 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 276 LGAIGTFLGGPLADRFGKKT----VILISLLASFPLALLLPF-AGPVFAYVLLGLIGVILTSSFSVTVVYAQELFPGK-- 348
Cdd:cd17312 231 GGIAGTILAGLLSDKLFGGRrapiAVIYMLLMTLSLALFWFFpHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKea 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 500857713 349 IGTMSGLTVGLAFGMGAIGSVALGSFIDTFGLTPTMIGVAFLPILGILAFLL 400
Cdd:cd17312 311 AGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLS 362
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
21-192 |
2.22e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 43.26 E-value: 2.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 21 YPILLIIGICHMLNDTLQAVIPAMFPI-LERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKrpMPYALPIALFS--- 96
Cdd:cd17337 207 NPKIAIGGIVRIINTLSQFGFPVFMPLyFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDK--IGWRRTVRWFGgvg 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 97 SAVGIFGLAFAP-----SFATILLCVVFIGLGSAIFHPEGSRVANMAaGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVP 171
Cdd:cd17337 285 CAISTLLFYYVPqlfghNYWAALIAAILFGIGLAGFVPLSALMPSLA-PEHKGAAMSILNLGAGLSNFVGPAIVTLFLGS 363
|
170 180
....*....|....*....|.
gi 500857713 172 LGQPGVAWfTIVGMIAVGFLL 192
Cdd:cd17337 364 FGAGGVVW-IFAGLYLLSAVL 383
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
46-400 |
3.50e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 42.63 E-value: 3.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 46 PILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATI----LLCVVFIG 121
Cdd:cd17393 23 PAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALalalFLFGAANG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 122 LGSAIFHPEGSRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALmlvplGQPGVAWFTIVGMIAVGFLLYISRWYAGR 201
Cdd:cd17393 103 ALDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGA-----GVSPGVHLLAAAVLLLLAALVAIRALLPG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 202 LQTIRAQAKKAPAKAARSELHRksaltALGIIVFLIFARSWYGNAISNFYAFYAIEQYGLTIKESQTYIFLFLILGAIGT 281
Cdd:cd17393 178 TGEAAEDRPDGAGKPGFLLPNR-----LLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGR 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 282 FLGGPLADRFGKKTVILIS-LLASFPLALLLPFAGPVFAYVLLGLIGVILTSSFSVTVVYAQELFPGKIGTMSGLTVGLA 360
Cdd:cd17393 253 LFGDRLVDRFGDVAVLRAGaLLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGLAAGIAVARVATLG 332
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 500857713 361 FGMGAIGSVALGSFIDTFGLTPTMIgvaFLPILGILAFLL 400
Cdd:cd17393 333 YLGFLVGPPLIGFLADATGLRTAFL---VVALLALLVALL 369
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
39-288 |
4.03e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 42.11 E-value: 4.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 39 AVIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATILLCVV 118
Cdd:COG0477 31 TIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 119 FIGLGSAIFHPEG-SRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAWFTIV-GMIAVGFLLYISR 196
Cdd:COG0477 111 LQGIGAGGLMPGAlALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPlGLLALVLRLRLPE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 197 WYAGRLQTIRAQAKKAPAKAARSELHRKSALTALGIIVFLIFARSWYGNAISNFYAFYAIEQYGLTIKESQTYIFLFLIL 276
Cdd:COG0477 191 SRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLL 270
|
250
....*....|..
gi 500857713 277 GAIGTFLGGPLA 288
Cdd:COG0477 271 LLALLLALLLLL 282
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
45-400 |
4.77e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 42.19 E-value: 4.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 45 FPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYA-LPIALFSSAVGIFGLAF-APSFATILLCVVFIGL 122
Cdd:cd17335 20 LSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKAlLLLSLLAAVLFFLSLFFvAQIFWLLLLLVILGAF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 123 GSAIFHPEGSRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAWFTIVGMIAVGFLLYISRWYAGRL 202
Cdd:cd17335 100 FSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSSTYKNYTIAFYVFAVLMLLALLLALKFPFRP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 203 QTIRAQAKKApakaarselHRKSALTALGIIVFLIFArsWY-GNAISNFYAFYAI--EQYGLtikeSQTYIFLFLILGAI 279
Cdd:cd17335 180 KHPEPNENTG---------GLLALLRNPRVLAFLLVA--FLmGFGHGLIYSFLFWhlQDLGG----SKTLIGLLWTVGVV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 280 GT----FLGGPLADRFGKKTVILISLLASFpLALLLPFAGPVFAYVLLGLI--GVILTSSFSVTVVYAQELFPGKIG-TM 352
Cdd:cd17335 245 SEipffFFSSRLIQRFGHVGLLYLGLLAYV-VRWLLYSFLENPWLVLPIELlhGLTFALVWAAAVSYASAAAPPGLRaTA 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 500857713 353 SGLTVGLAFGMG-AIGSVALGSFIDTFGLTPTMIGVAFLPILGILAFLL 400
Cdd:cd17335 324 QGLLQGLYFGLGgGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFL 372
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
234-400 |
5.66e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.64 E-value: 5.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 234 VFLIFARSWYGNAISNFYAFYAIEQYGLTIKESQTYIFLFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPF 313
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 314 AGPV-FAYVLLGLIGVILTSSFSVTVVYAQELFPGKIGTMSGLTVGLAFGMGAIGSVALGSFIDTFGLTPTMIGVAFLPI 392
Cdd:cd06174 81 APSFwLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
....*...
gi 500857713 393 LGILAFLL 400
Cdd:cd06174 161 LALLAAIL 168
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
46-400 |
6.25e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 41.84 E-value: 6.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 46 PILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPS--------FATILLCV 117
Cdd:cd17345 27 PYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSatssvglmFILLFLNG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 118 VFIGLGSAifhPEGSRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAW-FTIVGMIAVGFLLYISR 196
Cdd:cd17345 107 WFQGMGWP---PSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDGWWRGaFIFPAIIAIIVAVIVLF 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 197 WYAGRLQTI---RAQAKKAPAKAARSELHRKSALTALGII-----------------VFLIFARswYGnaISNFYAFYAI 256
Cdd:cd17345 184 LGKDTPESEglpPIEEYKGDYPEEADGEEEEQELSAWEIFvkyvlknkllwyiaianVFVYLVR--YG--ILDWAPTYLS 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 257 EQYGLTIKESQTYIFLFLILGAIGTFLGGPLADRF--GKKTVILISLLASFPLALLLPFAGP--VFAYVLLGLIGVILTS 332
Cdd:cd17345 260 EVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLfkGRRAPTGIIFMILVIVALIVYWLAPnvLVDLIALIALGFLIYG 339
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 333 SFSVTVVYAQELFPGK-IGTMSGLTVGLAFGMGAI-GSVALGSFIDTFGLTPTMIGVAFLPILGILAFLL 400
Cdd:cd17345 340 PVMLIGLQALELVPKKaAGTAAGLTGLFGYLGGSVlATALIGIIVDHFGWNGGFIVLLASCILAIIFLAL 409
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
273-401 |
6.94e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 41.41 E-value: 6.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 273 FLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAgPVFAYVLLG--LIGVILTSSFSVTVVYAQELFP---- 346
Cdd:cd17315 43 LLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALA-PNVWVLIVGrfLLGLGVGLASVLVPLYISEIAPakir 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 500857713 347 GKIGTMSGLTVGlaFGMGAIGSVALGSFIDTFGLTPTMIGVAFLP--ILGILAFLLP 401
Cdd:cd17315 122 GALGTLNQLMIT--FGILLAYLLGLALSLSPPGWWRLMFALAAVPalLQLLLMFFLP 176
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
53-336 |
7.37e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 41.52 E-value: 7.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 53 GLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFA-PSFATILLCVVFIGLGSAIFHPEG 131
Cdd:TIGR00886 33 GLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIRLFIGIAGGSFASCM 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 132 SRVANMAAGPRRGLAQSIYQVGGNTG----QAFAPLIAALMLVPLGQPG-VAW--------FTIVGMIAVGFLLYISRWY 198
Cdd:TIGR00886 113 PWISFFFPKKIQGTALGLAAGWGNMGggvaQFVMPPIIGSLIFGGGQPAhLAWgwafvivpAGILLLPALLIFFVGADTP 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 199 AGRLQTIRAQAKKAPAKAARSELhrkSALTALGIIVFLIFArswygnAISNFYAFYAIEQYGLTIKESQTYIFLFLILGA 278
Cdd:TIGR00886 193 PGKPATGKLSFKEALKVFGNRHT---WILALLYSVTFGSFL------GVSSIFAMLFKDQFGLSKVQAGAYASLGGFLGS 263
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 500857713 279 IGTFLGGPLADRFGKKTVILISLLASFPLALLLpFAGPVFAYVLLGLIGVILTSSFSV 336
Cdd:TIGR00886 264 LARPAGGAISDRLGGARKLLMNFLGVAMGAFLV-VLGLVSDGSLAAFIVLFVALFFFA 320
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
46-400 |
8.39e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 41.46 E-value: 8.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 46 PILErSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDK------RPMPYAL---PIALFSSAV----GIFGLAFA--PSF 110
Cdd:cd17313 24 PILQ-TLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRcnsrigRRRPFILvgaPLAALGLILipnaADIGLALGdgPRT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 111 ATILLCVVFIGL----GSAIFHPEGSRVANMAAGPRRGLAQSIYQVGGNTGQAFAPLIAAL--------MLVPLGQPGVA 178
Cdd:cd17313 103 WALVLFVLGIVLldfaMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAIlwdhnwfgFALGGNLKVPF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 179 WF-TIVGMIAVGFLLYISRWYAGRLQTIRAQAKKAPAKAARSELHRKSALTALGIIVFLIFARSWYG-NAISNFYAFY-A 255
Cdd:cd17313 183 YIgAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLKSLLKLLKIMPRSLLRLLLVIFFWWIAfFPFELFFTDYmG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 256 IEQYGLTIKESQTY----------IFLFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAGPVF-AYVLLG 324
Cdd:cd17313 263 EEVYHGTSAASSHYgagvrmgawgLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTvALVLFA 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 325 LIGV----ILTSSFSVTVVYAQELfPGKIGTMSGLTVGLAFGMGAIGSVALGSFIDTFGLTPTMIGVAFLPILGILAFLL 400
Cdd:cd17313 343 LGGIgwatININPYPLVSDYHSES-GRGQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
98-400 |
8.47e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.41 E-value: 8.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 98 AVGIFGLAFAPSFATILLCVVFIGLGSAifhpeGSRVANMA------AGPRRGLAQSIYQVGGNTGQAFAPLIAALMLVP 171
Cdd:cd17320 75 ILASLLCALASSIEQLLIARFLQGLGAA-----AGSVVARAivrdlySGAELAKIFSLLMMILAIAPALAPLLGGLLLLF 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 172 LGQPGVAWFTIVGMIAVGFLLYI----SRWYAGRLQTIRAQAKKAPAKAARSELHRKSALTALGIIVFLIFARSWygnai 247
Cdd:cd17320 150 FGWRAIFVFLALLGLLLLLLVLLflpeTLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAA----- 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 248 snfyAFYAIEQYGLTikeSQTYIFLFLILGA---IGTFLGGPLADRFGKKTVILISLLASFPLALLLPFA----GPVFAY 320
Cdd:cd17320 225 ----PFIYIEQLGLS---PAQFGLLFALNAIaliLGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAallgGLSLWP 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 321 VLLGLIGVILTSSFSVTVVYAQ--ELFPGKIGTMSGLTVGLAFGMGAIGSVALGSFIDTfGLTPTMIGVAFLPILGILAF 398
Cdd:cd17320 298 LVAPLFLIFFGFGLIFPNATSLalEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNG-TALPMGLLILVLGLLALLLL 376
|
..
gi 500857713 399 LL 400
Cdd:cd17320 377 IL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
278-404 |
1.03e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.00 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 278 AIGTFLGGPLADRFGKKTVILISLLAsFPLALLLPFAGPVFAYVLLGLIGVILTSS--FSVTVVYAQELFPGKIGT---- 351
Cdd:cd17324 48 ALGALLLGPLSDRIERRRLLLVLLLL-FILGNLLAALAPSFALLLLARALAGLAHGgfWAIAAAYAADLVPPEKRGraig 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 500857713 352 --MSGLTVGLAFGmgaigsVALGSFI-DTFGLTPTMIGVAF--LPILGILAFLLPSDQ 404
Cdd:cd17324 127 lvFSGLTLGLVLG------RPLGGLLgQLLGWRAAFLAIAVlaLLAALLLWRLLPSLP 178
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
272-397 |
1.26e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 40.64 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 272 LFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAGPVFAYVLLGLIGVILTSSFSVTVVYAQELFPGKIGT 351
Cdd:cd17330 42 SYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERA 121
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 500857713 352 MSGLTVGLAFGMGAI-GSVALGSFIDTFGLTPTMIGVAFLPILGILA 397
Cdd:cd17330 122 KAFGIISAAFGLGFIlGPALGGFLSTPYGYALPFLVAAALALLNLVL 168
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
274-401 |
1.37e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 40.63 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 274 LILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAGPVFAYVLLGLIGVILTSSFSVTV-VYAQELFPGKI-GT 351
Cdd:cd17359 46 LLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVpMYIAEVAPAEIrGR 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 500857713 352 MSGL-----TVG--LAFGMGAIGSVALGSFIDTFGLTPTMIGVAFLP--ILGILAFLLP 401
Cdd:cd17359 126 LVSLnqlmiVFGqlLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPaiLFLLGMLFIP 184
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
222-377 |
1.65e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.20 E-value: 1.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 222 HRKSALtaLGIIVFLIFARSWYgnaISNFYA-FYAIEQYGLTIKESQTYIFLFLILGAIGTFLGGPLADRFGKKTVIL-- 298
Cdd:cd17369 226 HWRALL--LAIGLRLAENVLFY---LFTTFAlSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLag 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 299 --ISLLASFPLALLLPFAGP---VFAYVLLGLIGVILTssFSVTVVYAQELFPGKIGTmSGltVGLAFGMGAIGSVALGS 373
Cdd:cd17369 301 alLAALFAFPFFWLLDTGSTwliVLAAVVVLGVLHGMM--YGPQAAFLAELFPTRVRY-TG--ASLGYQLGAILGGGFAP 375
|
....
gi 500857713 374 FIDT 377
Cdd:cd17369 376 LIAT 379
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
22-194 |
2.01e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.10 E-value: 2.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 22 PILLIIGICHMLNDTLQAVIPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDK-RPMPYALPIALFSSAVG 100
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 101 IFGLAFAPSFATILLCVVFIGLGSAIFHPEGSRVANMAAGPR-RGLAQSIYQVGGNTGQAFAPLIAALMLVPLGQPGVAW 179
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEiRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAF 363
|
170
....*....|....*
gi 500857713 180 FTIVGMIAVGFLLYI 194
Cdd:cd06174 364 LVLAVLLLLAAILLL 378
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
271-401 |
2.38e-03 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 39.91 E-value: 2.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 271 FLFLILGAIGTFLGGPLADRFGK-KTVILI----SLLASFPLALLLPFAGPVFAYVLLGLIGVILTSSFSVTVVYAQEL- 344
Cdd:cd17398 269 LTLVIAGLVGSVVAGIWLDKTKKyKETTIIvyilSFIGMVAFTFTLDLGSIWVVFLTAGALGFFMTGYLPVGFEFAAELt 348
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 500857713 345 FPGKIGTMSGLTVGLAFGMGAIGSVALGSFIDTFGLTPTMIGVAFLPILG-ILAFLLP 401
Cdd:cd17398 349 YPEPEGTSSGLLNASAQIFGIIFTLVMGALLDKVGALASNIVLSVALLLGtILTAFIK 406
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
272-401 |
2.52e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.95 E-value: 2.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 272 LFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAGPVFAYVLL----GLIGVILTSSFSVTVVYAQELFPG 347
Cdd:pfam00083 54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLivgrVLVGIGVGGASVLAPMYISEIAPK 133
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 500857713 348 KI-GTMSGLT-VGLAFG-MGAIGSVALGSFIDTFGLTPTMIGVAFLP--ILGILAFLLP 401
Cdd:pfam00083 134 KLrGALGSLYqLAITFGiLLAYIFGLGLNKTSNSDGWRIPLGLQLVPalLLIIGLLFLP 192
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
271-366 |
2.62e-03 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 39.58 E-value: 2.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 271 FLFLILGAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAGPVFAYVLLG-LIGVILTSSFSVTVVYAQELFPGKI 349
Cdd:cd17374 42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRfLAGFAVSGISINTLILGTEWTTPRH 121
|
90
....*....|....*..
gi 500857713 350 GTMSGLTVGLAFGMGAI 366
Cdd:cd17374 122 RALAITLTSCFFSIGQM 138
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
41-188 |
4.12e-03 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 39.14 E-value: 4.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 41 IPAMFPILERSMGLTFTQLGLIAFTLNMVSSVMQPAIGWYTDKRPMPYALPIALFSSAVGIFGLAFAPSFATILLCVVFI 120
Cdd:PLN00028 55 AAPLLPIIRDNLNLTKSDIGNAGIASVSGSIFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFI 134
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500857713 121 GLGSAIFHPEGSRVANMAAGPRRGLAQSIYQVGGNTG----QAFAPLIAALMLVPLGQPGVAW---FTIVGMIAV 188
Cdd:PLN00028 135 GFSLATFVSCQYWMSTMFNGKIVGTANGIAAGWGNLGggvtQLLMPLVFPLIKDAGAPSFTAWriaFFVPGLLHI 209
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
277-401 |
5.86e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 38.71 E-value: 5.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 277 GAIGTFLGGPLADRFGKKTVILISLLASFPLALLLPFAGPVFaYVLLG-LIGVILTSSFSVTV-VYAQELFPGKI-GTMs 353
Cdd:cd17358 54 ALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVW-MLYLGrFLAGFGGGAASVVVpVYIAEIAPKNVrGAL- 131
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 500857713 354 GLTVGLAFGMGAIGSVALGSFIDTFglTPTMIGVAFLPILGILAFLLP 401
Cdd:cd17358 132 GSLNQLLVNIGILLGYVLGSFLPWR--TLALIGAIPPVVFLILLFFIP 177
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
218-401 |
8.39e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 37.87 E-value: 8.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 218 RSELHRKSALTALGIIVFLIfarsWYGNAISNFYAFYAIEQYGLTIKESQTYIFLFLILGAIGTFLGGPLADRFGKKTVI 297
Cdd:COG0477 7 APTRRRRRALLALALGTFLE----GLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500857713 298 LISLLASFPLALLLPFA-GPVFAYVLLGLIGVILTSSFSVTVVYAQELFPGKIGTMSGLTVGLAFGMG-AIGSVALGSFI 375
Cdd:COG0477 83 LIGLLLFGLASLLCGLApSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGlALGPLLGGLLV 162
|
170 180
....*....|....*....|....*..
gi 500857713 376 DTFGL-TPTMIGVAFLPILGILAFLLP 401
Cdd:COG0477 163 AALGWrWIFLINAPLGLLALVLRLRLP 189
|
|
| |
