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Conserved domains on  [gi|500160237|ref|WP_011834907|]
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MarR family winged helix-turn-helix transcriptional regulator [Lactococcus cremoris]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
3-139 5.80e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 85.02  E-value: 5.80e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160237   3 TKKEAIGRLLKVASNQMSREFDNFAAQLDLTGQQMSILDFLGNQseegsgKEISQTMIELEFNIRRSTTTEILQRMEKRL 82
Cdd:COG1846    7 PAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEA------GGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 500160237  83 LINRRTSLTDARQKSVELTEEGKRYLPEIRAYIQAHNKKALTGLSTEEIAAVEKFLN 139
Cdd:COG1846   81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLR 137
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
3-139 5.80e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 85.02  E-value: 5.80e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160237   3 TKKEAIGRLLKVASNQMSREFDNFAAQLDLTGQQMSILDFLGNQseegsgKEISQTMIELEFNIRRSTTTEILQRMEKRL 82
Cdd:COG1846    7 PAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEA------GGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 500160237  83 LINRRTSLTDARQKSVELTEEGKRYLPEIRAYIQAHNKKALTGLSTEEIAAVEKFLN 139
Cdd:COG1846   81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLR 137
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
30-131 2.24e-12

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 59.14  E-value: 2.24e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160237    30 LDLTGQQMSILDFLGNqseegsgkEISQTMIEL--EFNIRRSTTTEILQRMEKRLLINRRTSLTDARQKSVELTEEGKRY 107
Cdd:smart00347   6 LGLTPTQFLVLRILYE--------EGPLSVSELakRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGREL 77

                           90       100
                   ....*....|....*....|....
gi 500160237   108 LPEIRAYIQAHNKKALTGLSTEEI 131
Cdd:smart00347  78 IEQLLEARSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 30-95 2.98e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 44.89  E-value: 2.98e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500160237   30 LDLTGQQMSILDFLGNqseegsGKEISQTMIELEFNIRRSTTTEILQRMEKRLLINRRTSLTDARQ 95
Cdd:pfam12802   1 LGLTPAQFRVLLALAR------NPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 75-131 1.59e-04

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 39.22  E-value: 1.59e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 500160237  75 LQRMEKRLLINRRTSLTDARQKSVELTEEGKRYLPEIRAYIQAHNKKALTGLSTEEI 131
Cdd:PRK03573  67 LDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEI 123
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
3-139 5.80e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 85.02  E-value: 5.80e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160237   3 TKKEAIGRLLKVASNQMSREFDNFAAQLDLTGQQMSILDFLGNQseegsgKEISQTMIELEFNIRRSTTTEILQRMEKRL 82
Cdd:COG1846    7 PAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEA------GGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 500160237  83 LINRRTSLTDARQKSVELTEEGKRYLPEIRAYIQAHNKKALTGLSTEEIAAVEKFLN 139
Cdd:COG1846   81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLR 137
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
30-131 2.24e-12

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 59.14  E-value: 2.24e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160237    30 LDLTGQQMSILDFLGNqseegsgkEISQTMIEL--EFNIRRSTTTEILQRMEKRLLINRRTSLTDARQKSVELTEEGKRY 107
Cdd:smart00347   6 LGLTPTQFLVLRILYE--------EGPLSVSELakRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGREL 77

                           90       100
                   ....*....|....*....|....
gi 500160237   108 LPEIRAYIQAHNKKALTGLSTEEI 131
Cdd:smart00347  78 IEQLLEARSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 30-95 2.98e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 44.89  E-value: 2.98e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500160237   30 LDLTGQQMSILDFLGNqseegsGKEISQTMIELEFNIRRSTTTEILQRMEKRLLINRRTSLTDARQ 95
Cdd:pfam12802   1 LGLTPAQFRVLLALAR------NPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 75-131 1.59e-04

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 39.22  E-value: 1.59e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 500160237  75 LQRMEKRLLINRRTSLTDARQKSVELTEEGKRYLPEIRAYIQAHNKKALTGLSTEEI 131
Cdd:PRK03573  67 LDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEI 123
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
49-107 1.98e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 39.03  E-value: 1.98e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 500160237  49 EGSGKEISQTMIELEFNIRRSTTTEILQRMEKRLLINRRtsltdaRQKSVELTEEGKRY 107
Cdd:COG1321   19 SEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYE------PYGGITLTEEGREL 71
PRK11139 PRK11139
DNA-binding transcriptional activator GcvA; Provisional
 94-113 8.19e-04

DNA-binding transcriptional activator GcvA; Provisional


Pssm-ID: 182990 [Multi-domain]  Cd Length: 297  Bit Score: 38.29  E-value: 8.19e-04
                         10        20
                 ....*....|....*....|
gi 500160237  94 RQKSVELTEEGKRYLPEIRA 113
Cdd:PRK11139  56 RNRSLLLTEEGQRYFLDIRE 75
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 32-96 1.14e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 35.22  E-value: 1.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500160237   32 LTGQQMSILDFLGNQseegsgKEISQTMIELEFNIRRSTTTEILQRMEKRLLINRRTSLTDARQK 96
Cdd:pfam01047   1 LTLTQFHILRILYEH------GPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
HTH_27 pfam13463
Winged helix DNA-binding domain;
32-104 2.43e-03

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 34.57  E-value: 2.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500160237   32 LTGQQMSILDFLGNQSEEGSGKEISQTMielefNIRRSTTTEILQRMEKRLLINRRTSLTDARQKSVELTEEG 104
Cdd:pfam13463   1 LTRLEALILHNIGHRGDPKTLADICFRL-----NVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
8-138 3.90e-03

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 35.64  E-value: 3.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500160237   8 IGRLLKVASNQMSREFDNFAAQLDLTGQQMSILDFLGNqseegsgkEISQTMIELE--FNIRRSTTTEILQRMEKRLLIN 85
Cdd:PRK11512  14 LGRLIHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRC--------AACITPVELKkvLSVDLGALTRMLDRLVCKGWVE 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 500160237  86 RRTSLTDARQKSVELTEEGKRYLPEIRAYIQAHNKKALT-GLSTEEIAAVEKFL 138
Cdd:PRK11512  86 RLPNPNDKRGVLVKLTTSGAAICEQCHQLVGQDLHQELTkNLTADEVATLEHLL 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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