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Conserved domains on  [gi|500045992|ref|WP_011726710|]
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OFA family MFS transporter [Mycolicibacterium smegmatis]

Protein Classification

OFA family MFS transporter( domain architecture ID 13024068)

OFA (oxalate:formate antiporter) family major facilitator superfamily (MFS) transporter similar to OFA, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation, to generate an electrochemical proton gradient that is the source of energy for ATP synthesis in this cell

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 34-435 1.13e-93

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 287.97  E-value: 1.13e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  34 RAWMLAFSWIAMAGIGVLQYGYGVALTALHVTEGRSLTAALWVLALWVVFQAGAAAPTAVLSHRFalSPSRAVPIGAALC 113
Cdd:cd17353    1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRG--GPRKAILIGGILF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 114 AAGPLTVAHTDNIALAILGYSVLSGTGAGIVYATCTATVAKWYPENRAARIGLVTGAVGCGAVPFIAAFALTLTSTTRTA 193
Cdd:cd17353   79 GLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 194 LFTAVAVIVLVVVAQVGSLLKDPPAGWWPAHVDPRQWAfdktlnrslrhNVTAIRQFSPAEAARTPAFVVMYLIMVIAAA 273
Cdd:cd17353  159 TFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANN-----------AENSPRDYTPREMLRTPTFWLLWLMFFLNAT 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 274 AALLAIVYVPIMAISQ-GFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASsaVPVA 352
Cdd:cd17353  228 AGLMLIGQAKPIGQEFaGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGS--VAVL 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 353 FVVFAGLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLISSHLMNP-FVVAGLLSLGAAAM 431
Cdd:cd17353  306 FVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAaFIIAAALSLVALAL 385


                 ....
gi 500045992 432 TRLL 435
Cdd:cd17353  386 ALLL 389
 
Name Accession Description Interval E-value
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 34-435 1.13e-93

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 287.97  E-value: 1.13e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  34 RAWMLAFSWIAMAGIGVLQYGYGVALTALHVTEGRSLTAALWVLALWVVFQAGAAAPTAVLSHRFalSPSRAVPIGAALC 113
Cdd:cd17353    1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRG--GPRKAILIGGILF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 114 AAGPLTVAHTDNIALAILGYSVLSGTGAGIVYATCTATVAKWYPENRAARIGLVTGAVGCGAVPFIAAFALTLTSTTRTA 193
Cdd:cd17353   79 GLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 194 LFTAVAVIVLVVVAQVGSLLKDPPAGWWPAHVDPRQWAfdktlnrslrhNVTAIRQFSPAEAARTPAFVVMYLIMVIAAA 273
Cdd:cd17353  159 TFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANN-----------AENSPRDYTPREMLRTPTFWLLWLMFFLNAT 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 274 AALLAIVYVPIMAISQ-GFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASsaVPVA 352
Cdd:cd17353  228 AGLMLIGQAKPIGQEFaGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGS--VAVL 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 353 FVVFAGLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLISSHLMNP-FVVAGLLSLGAAAM 431
Cdd:cd17353  306 FVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAaFIIAAALSLVALAL 385


                 ....
gi 500045992 432 TRLL 435
Cdd:cd17353  386 ALLL 389
2A0111 TIGR00890
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator ...
 34-431 2.16e-25

oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator family. Members include the oxalate/formate antiporter of Oxalobacter formigenes, where one substrate is decarboxylated in the cytosol into the other to consume a proton and drive an ion gradient. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273323 [Multi-domain]  Cd Length: 377  Bit Score: 106.76  E-value: 2.16e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992   34 RAWMLAFSWIAMAGIGVLQYGYGVALTALHVTEGRSLTAALWVLALWVVFQAGAAAPTAVLSHRFAlsPSRAVPIGAALC 113
Cdd:TIGR00890   1 RWWYVLVGTVIMCFTSGYVYTWTLLAPPLGRYFGVGVTAVAIWFTLLLIGLAMSMPVGGLLADKFG--PRAVAMLGGILY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  114 AAGPLTVAHTDNIALAILGYSvLSGTGAGIVYATCTATVAKWYPENRAARIGLVTGAVGCGAVPFIAAFALTLTSTTRTA 193
Cdd:TIGR00890  79 GLGFTFYAIADSLAALYLTYG-LASAGVGIAYGIALNTAVKWFPDKRGLASGIIIGGYGLGSFILSPLITSVINLEGVPA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  194 LFTAVAVIVLVVVAQVGSLLKDPPAgwwpahvdprqwafdktlNRSLRHNVTAIRQFSPAEAARTPAFVVMYLIMVIAAA 273
Cdd:TIGR00890 158 AFIYMGIIFLLVIVLGAFLIGYPPG------------------QLIKTNIEVSVKDYTVWEMLRTPQFWVLYLSFFLNAV 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  274 AALLAIVYVPIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYsASSAVPVAF 353
Cdd:TIGR00890 220 SGLLLIGLYKPYGQSLGLSDGFLVLAVSISSIFNGGGRPFLGALSDKIGRQKTMSIVFGISAVGMAAMLF-IPMLNDVLF 298

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500045992  354 VVFAGLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLISSHLMN-PFVVAGLLSLGAAAM 431
Cdd:TIGR00890 299 LATVALVFFTWGGTISLFPSLVSDIFGPANSAANYGFLYTAKAVAGIFGGLIASHALTEIGFEyTFIVTGAFALTSLAL 377
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
33-435 7.01e-23

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 99.96  E-value: 7.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  33 SRAWMLAFSWIAMAGIGVLQYGYGVALTALHVTEGRSLTAALWVLALWVVFQAGAAAPTAVLSHRFalSPSRAVPIGAAL 112
Cdd:COG2223    2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRF--GPRRVLLIGLLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 113 CAAGPLTVAHTDNIALaILGYSVLSGTGAGIVYATCTATVAKWYPENRAARI-GLVTGAVGCGAVPFIAAFALTLTSTTR 191
Cdd:COG2223   80 LGIGLLLLALAVSYWL-LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLAlGLAAGGGNLGAAVAAFLAPLLIAAFGW 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 192 TALFTAVAVIVLVVVAQVGSLLKDPPAGWWPAHVDPRQwafdktlnrslrhnvtairqfSPAEAARTPAFVVMYLIMVIA 271
Cdd:COG2223  159 RNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR---------------------DQLEALRDPRFWLLSLLYFGT 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 272 AAAALLAIVYVPIMAISQ-GFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASSavP 350
Cdd:COG2223  218 FGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGS--L 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 351 VAFVVFAGLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLISS--HLMNPFVVAGLLSLGA 428
Cdd:COG2223  296 WLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtgSYTAAFLVFAVLALVA 375


                 ....*..
gi 500045992 429 AAMTRLL 435
Cdd:COG2223  376 LVLTLLL 382
MFS_1 pfam07690
Major Facilitator Superfamily;
42-402 1.30e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 68.60  E-value: 1.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992   42 WIAMAGIGVLQYGYGVALTALHVTE-GRSLTAALWVLALWVVFQAGAAAPTAVLSHRFalSPSRAVPIGAALCAAGPLTV 120
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF--GRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  121 AHTDNIALAILGySVLSGTGAGIVYATCTATVAKWYP-ENRAARIGLVTGAVGCGAV--PFIAAFALTLTSTTRTALFTA 197
Cdd:pfam07690  80 LFASSLWLLLVL-RVLQGLGAGALFPAALALIADWFPpEERGRALGLVSAGFGLGAAlgPLLGGLLASLFGWRAAFLILA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  198 VAVIVLVVVAQvgsLLKDPPAGWWPAHVDPRqwafdktlnrslrhnvtAIRQFSPAEAARTPAFVVMYLIMVIAAAAALL 277
Cdd:pfam07690 159 ILSLLAAVLLL---LPRPPPESKRPKPAEEA-----------------RLSLIVAWKALLRDPVLWLLLALLLFGFAFFG 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  278 AIVYVPIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASSAVPVAFVVFA 357
Cdd:pfam07690 219 LLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLAL 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 500045992  358 GLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIG 402
Cdd:pfam07690 299 LLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
 
Name Accession Description Interval E-value
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 34-435 1.13e-93

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 287.97  E-value: 1.13e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  34 RAWMLAFSWIAMAGIGVLQYGYGVALTALHVTEGRSLTAALWVLALWVVFQAGAAAPTAVLSHRFalSPSRAVPIGAALC 113
Cdd:cd17353    1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRG--GPRKAILIGGILF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 114 AAGPLTVAHTDNIALAILGYSVLSGTGAGIVYATCTATVAKWYPENRAARIGLVTGAVGCGAVPFIAAFALTLTSTTRTA 193
Cdd:cd17353   79 GLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 194 LFTAVAVIVLVVVAQVGSLLKDPPAGWWPAHVDPRQWAfdktlnrslrhNVTAIRQFSPAEAARTPAFVVMYLIMVIAAA 273
Cdd:cd17353  159 TFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANN-----------AENSPRDYTPREMLRTPTFWLLWLMFFLNAT 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 274 AALLAIVYVPIMAISQ-GFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASsaVPVA 352
Cdd:cd17353  228 AGLMLIGQAKPIGQEFaGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGS--VAVL 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 353 FVVFAGLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLISSHLMNP-FVVAGLLSLGAAAM 431
Cdd:cd17353  306 FVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAaFIIAAALSLVALAL 385


                 ....
gi 500045992 432 TRLL 435
Cdd:cd17353  386 ALLL 389
2A0111 TIGR00890
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator ...
 34-431 2.16e-25

oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator family. Members include the oxalate/formate antiporter of Oxalobacter formigenes, where one substrate is decarboxylated in the cytosol into the other to consume a proton and drive an ion gradient. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273323 [Multi-domain]  Cd Length: 377  Bit Score: 106.76  E-value: 2.16e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992   34 RAWMLAFSWIAMAGIGVLQYGYGVALTALHVTEGRSLTAALWVLALWVVFQAGAAAPTAVLSHRFAlsPSRAVPIGAALC 113
Cdd:TIGR00890   1 RWWYVLVGTVIMCFTSGYVYTWTLLAPPLGRYFGVGVTAVAIWFTLLLIGLAMSMPVGGLLADKFG--PRAVAMLGGILY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  114 AAGPLTVAHTDNIALAILGYSvLSGTGAGIVYATCTATVAKWYPENRAARIGLVTGAVGCGAVPFIAAFALTLTSTTRTA 193
Cdd:TIGR00890  79 GLGFTFYAIADSLAALYLTYG-LASAGVGIAYGIALNTAVKWFPDKRGLASGIIIGGYGLGSFILSPLITSVINLEGVPA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  194 LFTAVAVIVLVVVAQVGSLLKDPPAgwwpahvdprqwafdktlNRSLRHNVTAIRQFSPAEAARTPAFVVMYLIMVIAAA 273
Cdd:TIGR00890 158 AFIYMGIIFLLVIVLGAFLIGYPPG------------------QLIKTNIEVSVKDYTVWEMLRTPQFWVLYLSFFLNAV 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  274 AALLAIVYVPIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYsASSAVPVAF 353
Cdd:TIGR00890 220 SGLLLIGLYKPYGQSLGLSDGFLVLAVSISSIFNGGGRPFLGALSDKIGRQKTMSIVFGISAVGMAAMLF-IPMLNDVLF 298

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500045992  354 VVFAGLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLISSHLMN-PFVVAGLLSLGAAAM 431
Cdd:TIGR00890 299 LATVALVFFTWGGTISLFPSLVSDIFGPANSAANYGFLYTAKAVAGIFGGLIASHALTEIGFEyTFIVTGAFALTSLAL 377
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
33-435 7.01e-23

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 99.96  E-value: 7.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  33 SRAWMLAFSWIAMAGIGVLQYGYGVALTALHVTEGRSLTAALWVLALWVVFQAGAAAPTAVLSHRFalSPSRAVPIGAAL 112
Cdd:COG2223    2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRF--GPRRVLLIGLLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 113 CAAGPLTVAHTDNIALaILGYSVLSGTGAGIVYATCTATVAKWYPENRAARI-GLVTGAVGCGAVPFIAAFALTLTSTTR 191
Cdd:COG2223   80 LGIGLLLLALAVSYWL-LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLAlGLAAGGGNLGAAVAAFLAPLLIAAFGW 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 192 TALFTAVAVIVLVVVAQVGSLLKDPPAGWWPAHVDPRQwafdktlnrslrhnvtairqfSPAEAARTPAFVVMYLIMVIA 271
Cdd:COG2223  159 RNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR---------------------DQLEALRDPRFWLLSLLYFGT 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 272 AAAALLAIVYVPIMAISQ-GFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASSavP 350
Cdd:COG2223  218 FGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGS--L 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 351 VAFVVFAGLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLISS--HLMNPFVVAGLLSLGA 428
Cdd:COG2223  296 WLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtgSYTAAFLVFAVLALVA 375


                 ....*..
gi 500045992 429 AAMTRLL 435
Cdd:COG2223  376 LVLTLLL 382
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 35-431 4.71e-16

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 79.62  E-value: 4.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  35 AWMLAFSWIAMAGIGVLQYGYGVALTALHVTEGRSLTAALWVLALWVVFQAGAAAPTAVLSHRFalSPSRAVPIGAALCA 114
Cdd:cd17355    2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRF--GPRRVMLLGLLLLA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 115 AGPLTVAHTDNIALAILGYSVLSGTGAGIVYATCTATVA-KWYPENRAARIGLVTGAVGCGAVPFIAAFALTLTSTTRTA 193
Cdd:cd17355   80 AGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAaWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 194 LFTAVAVIVLVVVAQVGSLLKDPPAgwwpahvDPRQWAFDKTLNRSLRHnvtairqfSPAEAARTPAFVVMYLIMVIAAA 273
Cdd:cd17355  160 ALLVLALLALLVLVPVLLLLRRRPA-------DLALRAYDDASPASPGS--------TLKEALRSASFWLLALAFFLCGF 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 274 AALLAIVYVPIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQlgLVYSASSAVPVAF 353
Cdd:cd17355  225 AVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGL--ALLLLLPFPPLAL 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 354 VVFAGLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLIS---SHLMnPFVVAGLLSLGAAA 430
Cdd:cd17355  303 LLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDrtgSYTA-AWALAVALGLIAAL 381


                 .
gi 500045992 431 M 431
Cdd:cd17355  382 L 382
MFS_1 pfam07690
Major Facilitator Superfamily;
42-402 1.30e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 68.60  E-value: 1.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992   42 WIAMAGIGVLQYGYGVALTALHVTE-GRSLTAALWVLALWVVFQAGAAAPTAVLSHRFalSPSRAVPIGAALCAAGPLTV 120
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF--GRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  121 AHTDNIALAILGySVLSGTGAGIVYATCTATVAKWYP-ENRAARIGLVTGAVGCGAV--PFIAAFALTLTSTTRTALFTA 197
Cdd:pfam07690  80 LFASSLWLLLVL-RVLQGLGAGALFPAALALIADWFPpEERGRALGLVSAGFGLGAAlgPLLGGLLASLFGWRAAFLILA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  198 VAVIVLVVVAQvgsLLKDPPAGWWPAHVDPRqwafdktlnrslrhnvtAIRQFSPAEAARTPAFVVMYLIMVIAAAAALL 277
Cdd:pfam07690 159 ILSLLAAVLLL---LPRPPPESKRPKPAEEA-----------------RLSLIVAWKALLRDPVLWLLLALLLFGFAFFG 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  278 AIVYVPIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASSAVPVAFVVFA 357
Cdd:pfam07690 219 LLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLAL 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 500045992  358 GLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIG 402
Cdd:pfam07690 299 LLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
34-435 3.40e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 67.59  E-value: 3.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  34 RAWMLAFSWIAMAGIGVLQYGYGVALTALHVTEGRSLTAALWVLALWVVFQAGAAAPTAVLSHRFalSPSRAVPIGAALC 113
Cdd:COG2271    8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRF--GRRRVLAIGLLLW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 114 AAGPLTVAHTDNIALAILGYsVLSGTGAGIVYATCTATVAKWYPENRAAR-IGLVTGAVGCGAVPFIAAFALTLTSTtrt 192
Cdd:COG2271   86 GLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPPKERGRaLGIFNAGGPLGGALAPPLLGWLLAAF--- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 193 alftavavivlvvvaqvgsllkdppaGWwpahvdprQWAFdktlnrslrhNVTAIrqfsPAEAARTPAFVVMYLIMVIAA 272
Cdd:COG2271  162 --------------------------GW--------RAAF----------LILGL----PGLLLALLRFWLLALAYFLVY 193

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 273 AAALLAIVYVP-IMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIqGCAQLGLVYSASSAVPV 351
Cdd:COG2271  194 FALYGFLTWLPtYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGL-LLAALALLLLALLPSPA 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 352 AFVVFAGLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIG-VGVPALLISSHLMNPFVVAGLLSLGAAA 430
Cdd:COG2271  273 LAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGpLLVGYLLDATGYQAAFLLLAALALLAAL 352


                 ....*
gi 500045992 431 MTRLL 435
Cdd:COG2271  353 LALLL 357
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 38-408 4.16e-12

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 67.44  E-value: 4.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  38 LAFSWIAMAGIGVLQYGYGVALTALHVTEGRSLTAALWVLALWVVFQAGAAAPTAVLSHRFALSPSRAVpiGAALCAAGP 117
Cdd:cd17314    5 LYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMAL--AGIMVLAGY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 118 LTVAHTDNIALAILGYSVLSGTGAGIVYATCTATVAKWYPENRAARIGLVTGAVGCGAVPFIAAFALTLTSTTRTALFTA 197
Cdd:cd17314   83 TYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 198 VAVIVLVVVAQVGSL-LKDPPAGWWPAHVDPRQWAFDKTLNRSLRHNVTAIRQFSPAeaarTPAFVVMYLImviaaaaal 276
Cdd:cd17314  163 LGILAAIVLSVVSLLgFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVL----IGGFLFIANM--------- 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 277 laivyVPIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASSAVPVAFVVF 356
Cdd:cd17314  230 -----ASLVRSLQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLT 304

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 500045992 357 AGLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPAL 408
Cdd:cd17314  305 GSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAK 356
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
33-399 1.80e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 65.00  E-value: 1.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  33 SRAWMLAFSWIAMAGIGVLQYGYGVALTALHVTEGRSLTAALWVLALWVVFQAGAAAPTAVLSHRFalSPSRAVPIGAAL 112
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF--GRRRVLLLGLLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 113 CAAGPLTVAHTDNIALAILGySVLSGTGAGIVYATCTATVAKWYP-ENRAARIGLVTGAVGCGAVPFIAAFALTLTSTTR 191
Cdd:COG2814   85 FALGSLLCALAPSLWLLLAA-RFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 192 TALFTAVAVIVLVVVAQVGSLLKDPpagwwpahvdprqwafdktlnrslRHNVTAIRQFSPAEAARTPAFVVMYLIMVIA 271
Cdd:COG2814  164 RWVFLVNAVLALLALLLLLRLLPES------------------------RPAARARLRGSLRELLRRPRLLLLLLLAFLL 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 272 AAAALLAIVYVPIMAISQ-GFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASsavP 350
Cdd:COG2814  220 GFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS---L 296

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 500045992 351 VAFVVFAGLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGG 399
Cdd:COG2814  297 WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
33-382 6.20e-11

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 63.74  E-value: 6.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  33 SRAWMLAFSWIAMAGIGVLQYGYGVALTALHVTEGRSLTAALWVLALWVVFQAGAAAPTAVLSHRFalSPSRAVPIGAAL 112
Cdd:COG2807   15 GRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF--GLERTLLLALLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 113 CAAGPLTVAHTDNIALAILGySVLSGTGAGIVYATCTATVAKWYPENRAARIGLVTGAVGCG-AVPFIAAFALTLTSTTR 191
Cdd:COG2807   93 LAAGLLLRSLAPSVALLLAG-TALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGaALAAGLTVPLAAALGWR 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 192 TALFTAVAVIVLVVvaqvgsllkdppAGWWPAhvdprqwafdktLNRSLRHNVTAIRQFSPAEAARTPAFVVMYLIMVIA 271
Cdd:COG2807  172 GALAVWALLALLAL------------LLWLPL------------LRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQ 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 272 AAAALLAIVYVPIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLG-RRQVLSAALLIQGCAQLGLVYSASSAVP 350
Cdd:COG2807  228 SLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPW 307

                        330       340       350
                 ....*....|....*....|....*....|..
gi 500045992 351 VAFVVFaglsGLSGGAFYPLIASLVADYFGEP 382
Cdd:COG2807  308 LWAVLL----GLGQGGLFPLALTLIGLRARTP 335
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 283-430 5.23e-10

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 60.70  E-value: 5.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 283 PIMAI----SQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASsavPVAFVVFAG 358
Cdd:cd17329   20 PFMAIylhqQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS---PWLFAIALV 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 500045992 359 LSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLISSHLMNPFVVAGLLSLGAAA 430
Cdd:cd17329   97 LTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAAL 168
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
251-435 5.80e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 57.29  E-value: 5.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 251 SPAEAARTPAFVVMYLIMVIAAAAALLAIVYVPIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAA 330
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 331 LLIQGCAQLGLVYSASsavPVAFVVFAGLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLI 410
Cdd:COG2814   82 LLLFALGSLLCALAPS---LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158

                        170       180
                 ....*....|....*....|....*.
gi 500045992 411 SS-HLMNPFVVAGLLSLGAAAMTRLL 435
Cdd:COG2814  159 DLfGWRWVFLVNAVLALLALLLLLRL 184
MFS_1 pfam07690
Major Facilitator Superfamily;
281-431 5.22e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 54.35  E-value: 5.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  281 YVPIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASSAvpvAFVVFAGLS 360
Cdd:pfam07690  19 LPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW---LLLVLRVLQ 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 500045992  361 GLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLISSHLMN-PFVVAGLLSLGAAAM 431
Cdd:pfam07690  96 GLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRaAFLILAILSLLAAVL 167
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 281-435 1.26e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 53.35  E-value: 1.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 281 YVPIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASsavPVAFVVFAGLS 360
Cdd:cd17325   18 ILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS---YWQLLLARFLQ 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500045992 361 GLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLISSHLMN-PFVVAGLLSLGAAAMTRLL 435
Cdd:cd17325   95 GLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRaPFLVCAALALLALVLALLL 170
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
33-402 3.68e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 52.16  E-value: 3.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  33 SRAWMLAFSWIAMAGIGVLQYGYGVALTALHVTEGRSLTAALWVLALWVVFQAGAAAPTAVLSHRFalSPSRAVPIGAAL 112
Cdd:COG0738    5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRF--GYKRGLLLGLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 113 CAAGPLTVAHTDNIALAILGYSVLsGTGAGIVYATCTATVAKWYPENRAARIGLVTGAVGCGAV--PFIAAFALT--LTS 188
Cdd:COG0738   83 MALGLLLFALAPSYPLLLLALFLL-GLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALlgPLLGGLLILlgLSL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 189 TTRTALFTAVAVIVLVVVAQVGSLLKDPPAgwwpahvdprqwafdktlnrslRHNVTAIRQFSPAEAARTPAFVVMYLIM 268
Cdd:COG0738  162 SWHLPYLILAVLLLLLALLFLRSKLPEIEE----------------------EEEEAAGSAASLKSLLKNPRLLLGGLAI 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 269 VIAAAAALLAIVYVPIMAISQ-GFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIqgcAQLGLVYSASS 347
Cdd:COG0738  220 FLYVGAEGAIGDWLPLYLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALL---AAVGLLLALLA 296

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 500045992 348 AVPVAFVVFAGLSGLSGGAFYPLIASLVADYFGEPNAVRnFSLVYSAKLFGGLIG 402
Cdd:COG0738  297 PGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAA-VSAVLIMGIVGGAIG 350
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 51-431 5.69e-07

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 51.40  E-value: 5.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  51 LQYGYGVALTALHVTEGRSLTAALWVLALWVVFQAGAAAPTAVLSHRFalsPSRAVPI-GAALCAAGPLTVAHTDNIALA 129
Cdd:cd17352   18 ILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRF---GCRPVAIaGGLLAALGLLLSSFATSLWQL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 130 ILGYSVLSGTGAGIVYATCTATVAKWYPENRAARIGLVTGAVGCGAV--PFIAAFALTLTSTTRTALFTAVAVIVLVVVA 207
Cdd:cd17352   95 YLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFvfPPLLRYLLDNYGWRGALLILGGLCLNLCVCG 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 208 QVGSLLKDPpagwwpahvdprqwafdktlnrslrhnvtairqfspaeaartpAFVVMYLIMVIAAAAALLAIVYVPIMAI 287
Cdd:cd17352  175 LLLRLLKDP-------------------------------------------TFVLLALGVSFAMLGFFVPFVYLPSYAK 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 288 SQGFSLAVAALAVGLLAVVNGTGRSIAGWASDR--LGRRQVLSAALLIQGCAQLGLVYSASsavPVAFVVFAGLSGLSGG 365
Cdd:cd17352  212 SLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATT---YVGLIVFSVLFGFCSG 288

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500045992 366 AFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLISSH--LMNPFVVAGLLSLGAAAM 431
Cdd:cd17352  289 SYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTgdYDAAFYFCGACLLLSGVL 356
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 283-431 2.97e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 49.09  E-value: 2.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 283 PIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIqgCAQLGLVYSASSAVPVAFVVFAGLSGL 362
Cdd:cd17477  212 PLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALL--GALAALLLPLVPGLPLALLVLLFLWGG 289

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 500045992 363 SGGAFYPLIASLVADYFGEPNAVRN---FSLVYSAKLFGGLIGVGVPALLISSHLMnPFVVAGLLSLGAAAM 431
Cdd:cd17477  290 AAGPLYTLALALAGDRLPGDELVAAnaaLLLLYGLGSVIGPLLAGALMDAFGPHGL-FLFLAAVALLFLLFL 360
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 108-435 3.80e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 48.73  E-value: 3.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 108 IGAALCAAGPLTVAHTDNIALAILGYsVLSGTGAGIVYATCTATVAKWYP-ENRAARIGLVTGAVGCGAV--PFIAAFAL 184
Cdd:cd17325   66 LGLLLLAVSTLLFAFATSYWQLLLAR-FLQGLASAAVWPAAMALIADIAPpEERGRAMGIFSSAIGLGFLigPLLGGLLA 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 185 TLTSttRTALFTAVAVIVLVVVAQVGSLLKDPPAgwwPAHVDPRQWAFDKTLNRSLRHNvtairqfspaeaartPAFVVM 264
Cdd:cd17325  145 DALG--YRAPFLVCAALALLALVLALLLLPEPRP---PPNKRAVSAARLRSGLRLLLRD---------------RRLLAL 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 265 YLIMVIAAAAALLAIVYVPIMAISQ-GFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVY 343
Cdd:cd17325  205 FLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL 284

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 344 SASsavPVAFVVFAGLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIG-VGVPALLISSHLMNPFVVAG 422
Cdd:cd17325  285 ATS---FWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGpLLGGFLYDAFGFATPFLAAA 361

                        330
                 ....*....|...
gi 500045992 423 LLSLGAAAMTRLL 435
Cdd:cd17325  362 ALLLLAAVLFLLL 374
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 281-435 7.33e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.81  E-value: 7.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 281 YVPIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGcaqLGLVYSASSAVPVAFVVFAGLS 360
Cdd:cd06174   18 LLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFA---LGALLFAFAPSFWLLLLGRFLL 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500045992 361 GLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIG---VGVPALLISSHLMNPFVVAGLLSLGAAAMTRLL 435
Cdd:cd06174   95 GLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGpllGGILASSLGFGWRAVFLIAAALALLAAILLLLV 172
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 313-438 2.65e-05

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 46.01  E-value: 2.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 313 IAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASSAVPVAFVVFAgLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVY 392
Cdd:cd17380   53 LGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRI-LLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVT 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 500045992 393 SAKLFGGLIGvgvpaLLISSHLMN------PFVVAGLLSLGAAAMTRLLHLP 438
Cdd:cd17380  132 AGSYLGTLLG-----GLIGPLLLEyygwpsVFYFFGLLGLLWALVWLIYLPP 178
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 42-435 3.81e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 45.50  E-value: 3.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  42 WIAMAGIGVLQYGYGVALTALHVTEGRSLTAALWVLALWVVFQAGAAAPTAVLSHRFalSPSRAVPIGAALCAAGPLTVA 121
Cdd:cd06174    2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF--GRRPVLLLGLLLFALGALLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 122 HTDNIALAILGYSVLSGTGAGIVYATCTATVAKWYPENRAARIGLVTGAVGCGAV--PFIAAFALTLTSTTRTALFTAVA 199
Cdd:cd06174   80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGIlgPLLGGILASSLGFGWRAVFLIAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 200 VIVLVVVAQVGSLLKDPPAgwwpAHVDPRQWAFDKTLNRSLRhnvtairqfspaEAARTPAFVVMYLIMVIAAAAALLAI 279
Cdd:cd06174  160 ALALLAAILLLLVVPDPPE----SARAKNEEASSKSVLKLLK------------RVLKNPGLWLLLLAIFLVNLAYYSFS 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 280 VYVPIMAISQG-FSLAVAALAVGLLAVVNGTGRSIAGWASDR-LGRRQVLSAALLIQGcaqLGLVYSASSAVPVAFVVFA 357
Cdd:cd06174  224 TLLPLFLLDLGgLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMA---LGLALLLLAPSLLLLLLLL 300

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500045992 358 GLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLISSHLMNPFVVAGLLSLGAAAMTRLL 435
Cdd:cd06174  301 LLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 284-432 4.39e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 45.29  E-value: 4.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 284 IMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASSAVPVAFVVFAGLSGLS 363
Cdd:cd17316  203 YLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFV 282

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 500045992 364 GGAFYPLIAsLVADYFgePNAVRN--FSLVYS-AKLFGGLIGVGVPALLISSHLMNPFVVAGLLSLGAAAMT 432
Cdd:cd17316  283 GGVWGALYA-YLAELF--PTEVRAtgVGLSYNlGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIV 351
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 286-435 3.62e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.59  E-value: 3.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 286 AISQGFSLAVAALAVGLLAVVNGTGRSIA----GWASDRLGRRQVLSAALLIQGCAQLGlvySASSAVPVAFVVFAGLSG 361
Cdd:cd17316   24 VLAAEFSLGLSLLQTGLLFAAGFLGRPIGallfGYLGDRIGRKKALILTLLLFGLATLL---IGLLPTPILLLVLRFLQG 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500045992 362 LSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLISSHLMN-----PFVVAGLLSLGAAAMTRLL 435
Cdd:cd17316  101 IGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDwgwriLFLIGALPALLALLLRRRT 179
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
 36-438 5.65e-04

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 41.99  E-value: 5.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  36 WMLAFSWIAMAGI--GVLQyGYGVALTALHVTEGRSLTAALWVLALWVVFQAGAAAPTAVLSHRFALSPsrAVPIGAALC 113
Cdd:cd17423    2 WVVVLAAFLQNALvfGVLR-SFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARP--VVMLGGLLS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 114 AAGPLTVAHTDNIALAILGYSVLSGTGAGIVYATCTATVAKWYPENRAARIGLVTGAVGCGAVPFIAAFALTL-TSTTRT 192
Cdd:cd17423   79 SLGFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLdTYAWRG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 193 ALFtaVAVIVLVVVAQVGSLLKdppagwwPAHVDPRQWAFDKTLNRSLRHNVTAIRQFSpAEAARTPAFVVMYLImviaa 272
Cdd:cd17423  159 ALL--LLSALSLHLVPCGALLR-------PLALPGDPPAPPRSLSAAFGLSLLTHRAFL-RYALATTLINTGYFI----- 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 273 aaallaiVYVPIMAISQ--GFSLAVAALAVGLLAVVNGTGRSIAGWASDrLGRRQVLSAALLIQGCAQLGLVYSASSAVP 350
Cdd:cd17423  224 -------PYVHLVAHARalGLGEYQAAFVVSVAAVADAVGRLFSGWLAD-LGPLRLLHLLVLWTALTGLSLLLLPLAKVY 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 351 VAFVVFAGLSGLSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALL--ISSHLMNPFVVAGLLSLGA 428
Cdd:cd17423  296 GSLLALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLrdITGDYTASFLVAGSFLLLG 375

                        410
                 ....*....|
gi 500045992 429 AAMtrLLHLP 438
Cdd:cd17423  376 SLI--LLTLP 383
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 282-447 5.71e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.81  E-value: 5.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 282 VPIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASsavPVAFVVFAGLSG 361
Cdd:cd17489   19 LPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS---VALLLVLRLIHG 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 362 LSGGAFYPLIASLVADYFGEPNAVRNFSL----VYSAKLFGGLIGVGVPALLISSHLmnpFVVAGLLSLGAAAMTRLLHL 437
Cdd:cd17489   96 IGWGAFTTAAATLVADIIPPSRRGEGIGYyglaTTLAMALGPALGLFLYQHLGFAVL---FIVAAVLALLALLLVFLVKD 172

                        170
                 ....*....|
gi 500045992 438 PGFPIVALPR 447
Cdd:cd17489  173 PPPVAAEEAE 182
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 283-435 6.19e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.77  E-value: 6.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 283 PIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIqgcAQLGLVYSASSAVPVAFVVFAGLSGL 362
Cdd:cd17324   23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLL---FILGNLLAALAPSFALLLLARALAGL 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500045992 363 SGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLISS-HLMNPFVVAGLLSLGAAAMTRLL 435
Cdd:cd17324  100 AHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlGWRAAFLAIAVLALLAALLLWRL 173
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
290-377 6.59e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.81  E-value: 6.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 290 GFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASSAVPVAFVVFAgLSGLSGGAFYP 369
Cdd:COG2211  260 GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAA-LAGIGLGAILV 338


                 ....*...
gi 500045992 370 LIASLVAD 377
Cdd:COG2211  339 LPWAMLAD 346
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 283-427 1.22e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 40.82  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992  283 PIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASSAVPVAFVVFaglSGL 362
Cdd:TIGR00881  19 PYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWAL---NGI 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500045992  363 SGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLISSHLMN--PFVVAGLLSLG 427
Cdd:TIGR00881  96 FQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWhwVFIVPGIIAII 162
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 259-381 2.36e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.85  E-value: 2.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 259 PAFVVMYLIMVIAAAAALLAIVYVPIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQ 338
Cdd:cd17478  195 RALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFL 274

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 500045992 339 LGLVYSAssavPVAFVVFAGLSGLSGGAFYPLIASLVADYFGE 381
Cdd:cd17478  275 LLFLLTP----GIWSYILLVLAGFLLFASFPVTVVLAQELLPG 313
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 284-438 3.49e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 39.61  E-value: 3.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 284 IMAISQGFSLAVAAlaVGLLAVVNGTGR----SIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASSAVpvaFVVFAGL 359
Cdd:cd17333   19 GPSLEEAFNLNVAD--VSVIFSSQNAGYligsLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYL---FVVLMFL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 360 SGLSGGAFYPLIASLVADYFGEPNAVRNfSLVYSAKLFGGLIGVGVPALLISSHL--MNPFVVAGLLSLGAAAMTRLLHL 437
Cdd:cd17333   94 AGLGAGILDTGANTFVGALFEESSATRL-NVLHGFFGLGALIGPLIATSLLTSELswSWAYLIIGLIYLLLAILILLTLF 172


                 .
gi 500045992 438 P 438
Cdd:cd17333  173 P 173
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 294-411 4.83e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 39.13  E-value: 4.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 294 AVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASSAVpVAFVVFAGLSGLSGGAFYPLIAS 373
Cdd:cd17332  256 AELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNL-VLILVLAVLAGIGYGGANLLPWA 334

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 500045992 374 LVAD---YFGEPNAVRNFSLVYSAKLF----GGLIGVGVPALLIS 411
Cdd:cd17332  335 MLADvidYGELKTGKRREGIFYSVMTFfrklGLALAGALVGLILS 379
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 282-447 5.01e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 38.64  E-value: 5.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 282 VPIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGCAQLGLVYSASsavPVAFVVFAGLSG 361
Cdd:COG0477   37 LPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPS---PELLIAARALQG 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 362 LSGGAFYPLIASLVADYFGEPNAVRNFSLVYSAKLFGGLIGVGVPALLISSH-LMNPFVVAGLLSLGAAAMTRLLHLPGF 440
Cdd:COG0477  114 IGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALgWRWIFLINAPLGLLALVLRLRLPESRG 193


                 ....*..
gi 500045992 441 PIVALPR 447
Cdd:COG0477  194 LLLALLA 200
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
257-438 7.02e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 38.68  E-value: 7.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 257 RTPAFVVMYLIMVIAAAAALLAIVYVPIMAISQGFSLAVAALAVGLLAVVNGTGRSIAGWASDRLGRRQVLSAALLIQGC 336
Cdd:COG0738    6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500045992 337 AQLGLVYSASsavPVAFVVFAGLSGLSGGAFYPLIASLVADYFGEpNAVRNFSLVYSAKLFGGLIGVGVPALLISSHL-- 414
Cdd:COG0738   86 GLLLFALAPS---YPLLLLALFLLGLGLGLLDVAANPYVAALGPE-TAASRLNLLHAFFSLGALLGPLLGGLLILLGLsl 161

                        170       180
                 ....*....|....*....|....*.
gi 500045992 415 --MNPFVVAGLLSLGAAAMTRLLHLP 438
Cdd:COG0738  162 swHLPYLILAVLLLLLALLFLRSKLP 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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