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Conserved domains on  [gi|499874814|ref|WP_011555548|]
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MULTISPECIES: biotin/lipoyl-binding carrier protein [Myxococcus]

Protein Classification

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit( domain architecture ID 10160553)

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit participates in the carboxylation of the carrier protein and the transfer of the carboxyl group to form malonyl-CoA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 4-69 1.28e-23

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


:

Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 84.00  E-value: 1.28e-23
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499874814  4 VAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:cd06850   2 VTAPMPGTVVKVLVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
 
Name Accession Description Interval E-value
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 4-69 1.28e-23

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 84.00  E-value: 1.28e-23
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499874814  4 VAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:cd06850   2 VTAPMPGTVVKVLVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 3-69 2.03e-22

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 88.36  E-value: 2.03e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499874814   3 DVAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:PRK09282 524 AVTSPMPGTVVKVKVKEGDKVKAGDTVLVLEAMKMENEIQAPVDGTVKEILVKEGDRVNPGDVLMEI 590
PycA COG1038
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
 3-69 1.09e-20

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 83.21  E-value: 1.09e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499874814    3 DVAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:COG1038  1078 HIGAPMPGTVVKVLVKEGDEVKKGDPLLTIEAMKMETTITAPRDGTVKEVLVKEGDQVEAGDLLIEL 1144
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 1-69 1.03e-13

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 59.15  E-value: 1.03e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499874814   1 MADVAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:pfam00364  5 SPMIGESVREGVVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLAKI 73
PDHac_trf_long TIGR01348
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model ...
 3-70 1.36e-08

pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model describes a subset of pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase specifically close by both phylogenetic and per cent identity (UPGMA) trees. Members of this set include two or three copies of the lipoyl-binding domain. E. coli AceF is a member of this model, while mitochondrial and some other bacterial forms belong to a separate model. [Energy metabolism, Pyruvate dehydrogenase]


Pssm-ID: 273566 [Multi-domain]  Cd Length: 546  Bit Score: 49.10  E-value: 1.36e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499874814    3 DVAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVLG 70
Cdd:TIGR01348   7 DIGDNEEGEVIEVLVKPGDKVEAGQSLITLESDKASMEVPSSAAGIIKEIKVKVGDTLPVGGVIATLE 74
 
Name Accession Description Interval E-value
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 4-69 1.28e-23

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 84.00  E-value: 1.28e-23
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499874814  4 VAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:cd06850   2 VTAPMPGTVVKVLVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 3-69 2.03e-22

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 88.36  E-value: 2.03e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499874814   3 DVAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:PRK09282 524 AVTSPMPGTVVKVKVKEGDKVKAGDTVLVLEAMKMENEIQAPVDGTVKEILVKEGDRVNPGDVLMEI 590
PRK12999 PRK12999
pyruvate carboxylase; Reviewed
 1-70 2.32e-22

pyruvate carboxylase; Reviewed


Pssm-ID: 237263 [Multi-domain]  Cd Length: 1146  Bit Score: 88.27  E-value: 2.32e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499874814    1 MAD------VAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVLG 70
Cdd:PRK12999 1070 KADpgnpghVGAPMPGSVVTVLVKEGDEVKAGDPLAVIEAMKMETTITAPVDGTVKRVLVKAGDQVEAGDLLVELE 1145
PycA COG1038
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
 3-69 1.09e-20

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 83.21  E-value: 1.09e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499874814    3 DVAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:COG1038  1078 HIGAPMPGTVVKVLVKEGDEVKKGDPLLTIEAMKMETTITAPRDGTVKEVLVKEGDQVEAGDLLIEL 1144
PRK08225 PRK08225
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 1-70 1.32e-20

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 181304 [Multi-domain]  Cd Length: 70  Bit Score: 76.75  E-value: 1.32e-20
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499874814  1 MADVAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVLG 70
Cdd:PRK08225  1 MTKVYASMAGNVWKIVVKVGDTVEEGQDVVILESMKMEIPIVAEEAGTVKKINVQEGDFVNEGDVLLEIE 70
PRK14040 PRK14040
oxaloacetate decarboxylase subunit alpha;
3-70 1.56e-20

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 237592 [Multi-domain]  Cd Length: 593  Bit Score: 83.06  E-value: 1.56e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499874814   3 DVAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVLG 70
Cdd:PRK14040 526 PVTAPLAGNIFKVIVTEGQTVAEGDVLLILEAMKMETEIRAAQAGTVRGIAVKEGDAVAVGDTLLTLA 593
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 4-70 1.55e-19

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 75.70  E-value: 1.55e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499874814   4 VAAHITGTV-------WKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVLG 70
Cdd:COG0511   63 VKSPMVGTFyrapspgAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVIE 136
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 4-70 2.97e-14

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 62.57  E-value: 2.97e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499874814   4 VAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVLG 70
Cdd:PRK05641  87 VTAPMPGKILRILVREGQQVKVGQGLLILEAMKMENEIPAPKDGVVKKILVKEGDTVDTGQPLIELG 153
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 1-69 1.03e-13

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 59.15  E-value: 1.03e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499874814   1 MADVAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:pfam00364  5 SPMIGESVREGVVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLAKI 73
PRK06549 PRK06549
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 4-70 3.80e-12

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235826 [Multi-domain]  Cd Length: 130  Bit Score: 56.74  E-value: 3.80e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499874814   4 VAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVLG 70
Cdd:PRK06549  64 MPSPMPGTILKVLVAVGDQVTENQPLLILEAMKMENEIVASSAGTVTAIHVTPGQVVNPGDGLITIG 130
PRK05889 PRK05889
biotin/lipoyl-binding carrier protein;
3-69 2.73e-10

biotin/lipoyl-binding carrier protein;


Pssm-ID: 180306 [Multi-domain]  Cd Length: 71  Bit Score: 50.58  E-value: 2.73e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499874814  3 DVAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:PRK05889  4 DVRAEIVASVLEVVVNEGDQIGKGDTLVLLESMKMEIPVLAEVAGTVSKVSVSVGDVIQAGDLIAVI 70
Biotinyl_lipoyl_domains cd06663
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the ...
 9-69 4.05e-10

Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, or methylamine, respectively, between components of the complex/protein via a biotinyl or lipoyl group, which is covalently attached to a highly conserved lysine residue.


Pssm-ID: 133456 [Multi-domain]  Cd Length: 73  Bit Score: 50.13  E-value: 4.05e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499874814  9 TGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:cd06663  13 DGTVVKWLKKVGDKVKKGDVLAEIEAMKATSDVEAPKSGTVKKVLVKEGTKVEGDTPLVKI 73
AceF COG0508
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component ...
 10-69 2.83e-09

Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [Energy production and conversion]; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440274 [Multi-domain]  Cd Length: 77  Bit Score: 48.14  E-value: 2.83e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 499874814 10 GTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:COG0508  17 GTIVEWLVKEGDTVKEGDPLAEVETDKATMEVPAPAAGVLLEILVKEGDTVPVGAVIAVI 76
PRK14042 PRK14042
pyruvate carboxylase subunit B; Provisional
 2-67 3.93e-09

pyruvate carboxylase subunit B; Provisional


Pssm-ID: 172536 [Multi-domain]  Cd Length: 596  Bit Score: 50.49  E-value: 3.93e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499874814   2 ADVAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLV 67
Cdd:PRK14042 526 GDITVAIPGSIIAIHVSAGDEVKAGQAVLVIEAMKMETEIKAPANGVVAEILCQKGDKVTPGQVLI 591
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 10-70 4.92e-09

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 50.21  E-value: 4.92e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499874814  10 GTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVLG 70
Cdd:PRK11855  16 VEVIEWLVKEGDTVEEDQPLVTVETDKATMEIPSPAAGVVKEIKVKVGDTVSVGGLLAVIE 76
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 10-70 5.53e-09

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 50.21  E-value: 5.53e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499874814  10 GTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVLG 70
Cdd:PRK11855 133 VEVIEWLVKVGDTVEEDQSLITVETDKATMEIPSPVAGVVKEIKVKVGDKVSVGSLLVVIE 193
PDHac_trf_long TIGR01348
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model ...
 3-70 1.36e-08

pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model describes a subset of pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase specifically close by both phylogenetic and per cent identity (UPGMA) trees. Members of this set include two or three copies of the lipoyl-binding domain. E. coli AceF is a member of this model, while mitochondrial and some other bacterial forms belong to a separate model. [Energy metabolism, Pyruvate dehydrogenase]


Pssm-ID: 273566 [Multi-domain]  Cd Length: 546  Bit Score: 49.10  E-value: 1.36e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499874814    3 DVAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVLG 70
Cdd:TIGR01348   7 DIGDNEEGEVIEVLVKPGDKVEAGQSLITLESDKASMEVPSSAAGIIKEIKVKVGDTLPVGGVIATLE 74
BCCP TIGR00531
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify ...
 17-69 2.58e-08

acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase.The gene name is accB or fabE. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273123 [Multi-domain]  Cd Length: 155  Bit Score: 47.14  E-value: 2.58e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 499874814   17 VQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:TIGR00531 102 VEVGDKVNKGQTVCIVEAMKMMNEIEAEKAGTVVAILVENGQPVEYGEPLIVI 154
PDHac_trf_long TIGR01348
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model ...
 3-69 1.38e-07

pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model describes a subset of pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase specifically close by both phylogenetic and per cent identity (UPGMA) trees. Members of this set include two or three copies of the lipoyl-binding domain. E. coli AceF is a member of this model, while mitochondrial and some other bacterial forms belong to a separate model. [Energy metabolism, Pyruvate dehydrogenase]


Pssm-ID: 273566 [Multi-domain]  Cd Length: 546  Bit Score: 46.41  E-value: 1.38e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499874814    3 DVAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:TIGR01348 123 DIGDIEKVTVIEVLVKVGDTVSADQSLITLESDKASMEVPAPASGVVKSVKVKVGDSVPTGDLILTL 189
PRK07051 PRK07051
biotin carboxyl carrier domain-containing protein;
17-69 7.73e-07

biotin carboxyl carrier domain-containing protein;


Pssm-ID: 180811 [Multi-domain]  Cd Length: 80  Bit Score: 41.92  E-value: 7.73e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 499874814 17 VQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:PRK07051 26 VEVGDAVAAGDVVGLIEVMKQFTEVEAEAAGRVVEFLVEDGEPVEAGQVLARI 78
aceF PRK11854
pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated
 10-70 1.22e-06

pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated


Pssm-ID: 236999 [Multi-domain]  Cd Length: 633  Bit Score: 43.45  E-value: 1.22e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499874814  10 GTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVLG 70
Cdd:PRK11854  15 VEVTEILVKVGDKVEAEQSLITVEGDKASMEVPSPQAGVVKEIKVKVGDKVETGALIMIFE 75
aceF PRK11854
pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated
 10-70 1.47e-06

pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated


Pssm-ID: 236999 [Multi-domain]  Cd Length: 633  Bit Score: 43.45  E-value: 1.47e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499874814  10 GTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVLG 70
Cdd:PRK11854 118 VEVTEILVKVGDTVEAEQSLITVEGDKASMEVPAPFAGTVKEIKVNVGDKVSTGSLIMVFE 178
aceF PRK11854
pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated
 10-70 2.08e-06

pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated


Pssm-ID: 236999 [Multi-domain]  Cd Length: 633  Bit Score: 42.68  E-value: 2.08e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499874814  10 GTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVLG 70
Cdd:PRK11854 219 VEVTEVMVKVGDKVEAEQSLITVEGDKASMEVPAPFAGTVKEIKVNVGDKVKTGSLIMRFE 279
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 17-60 1.82e-05

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 40.21  E-value: 1.82e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 499874814  17 VQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSV 60
Cdd:PLN02983 220 VKVGDKVQKGQVVCIIEAMKLMNEIEADQSGTIVEILAEDGKPV 263
sucB TIGR01347
2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This ...
 10-70 3.96e-04

2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This model describes the TCA cycle 2-oxoglutarate system E2 component, dihydrolipoamide succinyltransferase. It is closely related to the pyruvate dehydrogenase E2 component, dihydrolipoamide acetyltransferase. The seed for this model includes mitochondrial and Gram-negative bacterial forms. Mycobacterial candidates are highly derived, differ in having and extra copy of the lipoyl-binding domain at the N-terminus. They score below the trusted cutoff, but above the noise cutoff and above all examples of dihydrolipoamide acetyltransferase. [Energy metabolism, TCA cycle]


Pssm-ID: 273565 [Multi-domain]  Cd Length: 403  Bit Score: 36.25  E-value: 3.96e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499874814   10 GTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVLG 70
Cdd:TIGR01347  15 GTVAEWHKKVGDTVKRDENIVEIETDKVVLEVPSPADGVLQEILFKEGDTVESGQVLAILE 75
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 2-34 8.50e-04

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 35.30  E-value: 8.50e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 499874814   2 ADVAAHITGTVWKIEVQVGQQVNAGDTLVILES 34
Cdd:COG0845   24 VEVRARVSGRVEEVLVDEGDRVKKGQVLARLDP 56
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
3-34 1.27e-03

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 35.02  E-value: 1.27e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 499874814   3 DVAAHITGTVWKIEVQVGQQVNAGDTLVILES 34
Cdd:COG1566   47 TVAAKVSGRVTEVLVKEGDRVKKGQVLARLDP 78
type_I_hlyD TIGR01843
type I secretion membrane fusion protein, HlyD family; Type I secretion is an ABC transport ...
 45-69 2.30e-03

type I secretion membrane fusion protein, HlyD family; Type I secretion is an ABC transport process that exports proteins, without cleavage of any signal sequence, from the cytosol to extracellular medium across both inner and outer membranes. The secretion signal is found in the C-terminus of the transported protein. This model represents the adaptor protein between the ATP-binding cassette (ABC) protein of the inner membrane and the outer membrane protein, and is called the membrane fusion protein. This model selects a subfamily closely related to HlyD; it is defined narrowly and excludes, for example, colicin V secretion protein CvaA and multidrug efflux proteins. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 130902 [Multi-domain]  Cd Length: 423  Bit Score: 34.21  E-value: 2.30e-03
                          10        20
                  ....*....|....*....|....*
gi 499874814   45 DGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:TIGR01843  50 EGGIVREILVREGDRVKAGQVLVEL 74
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
38-69 2.48e-03

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 34.25  E-value: 2.48e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 499874814  38 EMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:COG1566   45 VVTVAAKVSGRVTEVLVKEGDRVKKGQVLARL 76
PTZ00144 PTZ00144
dihydrolipoamide succinyltransferase; Provisional
 9-69 4.07e-03

dihydrolipoamide succinyltransferase; Provisional


Pssm-ID: 240289 [Multi-domain]  Cd Length: 418  Bit Score: 33.50  E-value: 4.07e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499874814   9 TGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVL 69
Cdd:PTZ00144  58 EGTVVEWKKKVGDYVKEDEVICIIETDKVSVDIRAPASGVITKIFAEEGDTVEVGAPLSEI 118
PRK11892 PRK11892
pyruvate dehydrogenase subunit beta; Provisional
 10-56 5.06e-03

pyruvate dehydrogenase subunit beta; Provisional


Pssm-ID: 237011 [Multi-domain]  Cd Length: 464  Bit Score: 33.35  E-value: 5.06e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 499874814  10 GTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKE 56
Cdd:PRK11892  17 GTLAKWLKKEGDKVKSGDVIAEIETDKATMEVEAVDEGTLGKILVPE 63
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 17-68 5.52e-03

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 32.99  E-value: 5.52e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499874814  17 VQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEirvkeaQSVNEGDVLVV 68
Cdd:PRK14875  24 VQEGDEVEKGDELLDVETDKITNEVEAPAAGTLRR------QVAQEGETLPV 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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