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Conserved domains on  [gi|499845637|ref|WP_011526371|]
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NlpC/P60 family N-terminal domain-containing protein [Lawsonia intracellularis]

Protein Classification

N_NLPC_P60 and SH3_6 domain-containing protein( domain architecture ID 10584084)

protein containing domains N_NLPC_P60, SH3_6, SH3_7, and NLPC_P60

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
N_NLPC_P60 pfam12912
NLPC_P60 stabilising domain, N term; This domain, at the N-terminus, appears to be the ...
 22-129 8.16e-37

NLPC_P60 stabilising domain, N term; This domain, at the N-terminus, appears to be the stabilising domain for the structure from Swiss:Q72DN3, PDB:3m1u, which is a four-domain protein. The next domain is an SH3b1, the third an SH3b2 and the last, the C-terminal region, the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, pfam00877 (details derived from TOPSAN).


:

Pssm-ID: 432870  Cd Length: 107  Bit Score: 130.67  E-value: 8.16e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499845637   22 KTFNCVSPQLG-TIKDLEVFPQDLQVYSSVL-PQDPLITKDRMLDEYALFKKHFFQPWSKDKASVPASTVYSIFDRPNTK 99
Cdd:pfam12912   1 KTPKAVLPPTKsEIADLRRFPQDLTVYADNAgPDRPLLSDARQAALYEDFLRRFFAPWNQTKPSVSAEDALWAFAAFGTK 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 499845637  100 eniRWWAENLLPWTDIHWDEVKKNAAISTY 129
Cdd:pfam12912  81 ---RGYGENLQPWPPKRWDALAANAALETY 107
SH3_6 pfam12913
SH3 domain (SH3b1 type); This domain appears to be an SH3 domain of the SH3b1-type, and is ...
 153-204 8.23e-24

SH3 domain (SH3b1 type); This domain appears to be an SH3 domain of the SH3b1-type, and is just C-terminal to an N-terminal domain that is probably the stabilising domain for the structure from Swiss:Q72DN3, PDB:3m1u, which is a four-domain protein. The next domain is an SH3b2 and the last, the C-terminal region, is the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, pfam00877 (details derived from TOPSAN).


:

Pssm-ID: 432871  Cd Length: 53  Bit Score: 93.47  E-value: 8.23e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 499845637  153 FFLNPQTAGEGFPFNYLIESNLHAGTPVFITHTSTNGDWVFIETDLVSGWVP 204
Cdd:pfam12913   2 LFYDPSLAGEGYPFDYLQNSALHPGTPVLISHYSADGAWLFVETPFASGWVP 53
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
232-415 8.94e-12

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 64.34  E-value: 8.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499845637 232 VALNGRSGRHVTTGYLGTVLPIIKSTPTELVLLAPLRDQHRRARITEVYVSKIHTTIIPHELTASFIADIGNPLLGQLYG 311
Cdd:COG0791   37 ALVAAAAAVLAAAALLAGPAAAVAGAAAPAVGSAGAAAAAAAAKAGSSAAKSAAGASAPPSSTAEAIVAAALSYLGTPYV 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499845637 312 WGGS--FGhRDCSELMKDLFIPFGIWLPRNSQAQIHAWNYIDTTQLLE-DEVYqlmkdkaipFATLIGFKGHIGLYLGmy 388
Cdd:COG0791  117 WGGTspSG-FDCSGLVQYVYRQAGISLPRTSADQAAAGTPVSRSELQPgDLVF---------FRTGGGGISHVGIYLG-- 184

                        170       180       190
                 ....*....|....*....|....*....|..
gi 499845637 389 NNTpaMLHDVWG-----IRTIQSGSEGRHILG 415
Cdd:COG0791  185 NGK--FIHASSSgkgvrISSLDSPYWKSRYVG 214
 
Name Accession Description Interval E-value
N_NLPC_P60 pfam12912
NLPC_P60 stabilising domain, N term; This domain, at the N-terminus, appears to be the ...
 22-129 8.16e-37

NLPC_P60 stabilising domain, N term; This domain, at the N-terminus, appears to be the stabilising domain for the structure from Swiss:Q72DN3, PDB:3m1u, which is a four-domain protein. The next domain is an SH3b1, the third an SH3b2 and the last, the C-terminal region, the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, pfam00877 (details derived from TOPSAN).


Pssm-ID: 432870  Cd Length: 107  Bit Score: 130.67  E-value: 8.16e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499845637   22 KTFNCVSPQLG-TIKDLEVFPQDLQVYSSVL-PQDPLITKDRMLDEYALFKKHFFQPWSKDKASVPASTVYSIFDRPNTK 99
Cdd:pfam12912   1 KTPKAVLPPTKsEIADLRRFPQDLTVYADNAgPDRPLLSDARQAALYEDFLRRFFAPWNQTKPSVSAEDALWAFAAFGTK 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 499845637  100 eniRWWAENLLPWTDIHWDEVKKNAAISTY 129
Cdd:pfam12912  81 ---RGYGENLQPWPPKRWDALAANAALETY 107
SH3_6 pfam12913
SH3 domain (SH3b1 type); This domain appears to be an SH3 domain of the SH3b1-type, and is ...
 153-204 8.23e-24

SH3 domain (SH3b1 type); This domain appears to be an SH3 domain of the SH3b1-type, and is just C-terminal to an N-terminal domain that is probably the stabilising domain for the structure from Swiss:Q72DN3, PDB:3m1u, which is a four-domain protein. The next domain is an SH3b2 and the last, the C-terminal region, is the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, pfam00877 (details derived from TOPSAN).


Pssm-ID: 432871  Cd Length: 53  Bit Score: 93.47  E-value: 8.23e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 499845637  153 FFLNPQTAGEGFPFNYLIESNLHAGTPVFITHTSTNGDWVFIETDLVSGWVP 204
Cdd:pfam12913   2 LFYDPSLAGEGYPFDYLQNSALHPGTPVLISHYSADGAWLFVETPFASGWVP 53
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
232-415 8.94e-12

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 64.34  E-value: 8.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499845637 232 VALNGRSGRHVTTGYLGTVLPIIKSTPTELVLLAPLRDQHRRARITEVYVSKIHTTIIPHELTASFIADIGNPLLGQLYG 311
Cdd:COG0791   37 ALVAAAAAVLAAAALLAGPAAAVAGAAAPAVGSAGAAAAAAAAKAGSSAAKSAAGASAPPSSTAEAIVAAALSYLGTPYV 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499845637 312 WGGS--FGhRDCSELMKDLFIPFGIWLPRNSQAQIHAWNYIDTTQLLE-DEVYqlmkdkaipFATLIGFKGHIGLYLGmy 388
Cdd:COG0791  117 WGGTspSG-FDCSGLVQYVYRQAGISLPRTSADQAAAGTPVSRSELQPgDLVF---------FRTGGGGISHVGIYLG-- 184

                        170       180       190
                 ....*....|....*....|....*....|..
gi 499845637 389 NNTpaMLHDVWG-----IRTIQSGSEGRHILG 415
Cdd:COG0791  185 NGK--FIHASSSgkgvrISSLDSPYWKSRYVG 214
SH3_7 pfam12914
SH3 domain of SH3b2 type; This domain appears to be an SH3 domain of the SH3b2-type, and is ...
 215-258 9.83e-10

SH3 domain of SH3b2 type; This domain appears to be an SH3 domain of the SH3b2-type, and is the second SH3 domain to be found, downstream of an N-terminal domain that is probably the stabilising domain, for the structure from Swiss:Q72DN3, PDB:3m1u, which is a four-domain protein. The last, the C-terminal region, is the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, pfam00877 (details derived from TOPSAN).


Pssm-ID: 432872  Cd Length: 47  Bit Score: 53.67  E-value: 9.83e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 499845637  215 ISKWFSsLPQAAIIHDNVALNGRSGRHVTTGYLGTVLPIIKSTP 258
Cdd:pfam12914   5 VTIWQN-LPYAAVIRDNVPLYDAKGRFLFTARIGTLLPLLGEDA 47
PRK13914 PRK13914
invasion associated endopeptidase;
306-386 4.47e-05

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 45.56  E-value: 4.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499845637 306 LGQLYGWGG----SFghrDCSELMKDLFIPFGIWLPRNSQAQihawnYIDTTQLLEDEvyqlmkdkAIPfATLIGFK--- 378
Cdd:PRK13914 377 LGKAYSWGGngptTF---DCSGYTKYVFAKAGISLPRTSGAQ-----YASTTRISESQ--------AKP-GDLVFFDygs 439

                         90
                 ....*....|
gi 499845637 379 --GHIGLYLG 386
Cdd:PRK13914 440 giSHVGIYVG 449
 
Name Accession Description Interval E-value
N_NLPC_P60 pfam12912
NLPC_P60 stabilising domain, N term; This domain, at the N-terminus, appears to be the ...
 22-129 8.16e-37

NLPC_P60 stabilising domain, N term; This domain, at the N-terminus, appears to be the stabilising domain for the structure from Swiss:Q72DN3, PDB:3m1u, which is a four-domain protein. The next domain is an SH3b1, the third an SH3b2 and the last, the C-terminal region, the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, pfam00877 (details derived from TOPSAN).


Pssm-ID: 432870  Cd Length: 107  Bit Score: 130.67  E-value: 8.16e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499845637   22 KTFNCVSPQLG-TIKDLEVFPQDLQVYSSVL-PQDPLITKDRMLDEYALFKKHFFQPWSKDKASVPASTVYSIFDRPNTK 99
Cdd:pfam12912   1 KTPKAVLPPTKsEIADLRRFPQDLTVYADNAgPDRPLLSDARQAALYEDFLRRFFAPWNQTKPSVSAEDALWAFAAFGTK 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 499845637  100 eniRWWAENLLPWTDIHWDEVKKNAAISTY 129
Cdd:pfam12912  81 ---RGYGENLQPWPPKRWDALAANAALETY 107
SH3_6 pfam12913
SH3 domain (SH3b1 type); This domain appears to be an SH3 domain of the SH3b1-type, and is ...
 153-204 8.23e-24

SH3 domain (SH3b1 type); This domain appears to be an SH3 domain of the SH3b1-type, and is just C-terminal to an N-terminal domain that is probably the stabilising domain for the structure from Swiss:Q72DN3, PDB:3m1u, which is a four-domain protein. The next domain is an SH3b2 and the last, the C-terminal region, is the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, pfam00877 (details derived from TOPSAN).


Pssm-ID: 432871  Cd Length: 53  Bit Score: 93.47  E-value: 8.23e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 499845637  153 FFLNPQTAGEGFPFNYLIESNLHAGTPVFITHTSTNGDWVFIETDLVSGWVP 204
Cdd:pfam12913   2 LFYDPSLAGEGYPFDYLQNSALHPGTPVLISHYSADGAWLFVETPFASGWVP 53
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
232-415 8.94e-12

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 64.34  E-value: 8.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499845637 232 VALNGRSGRHVTTGYLGTVLPIIKSTPTELVLLAPLRDQHRRARITEVYVSKIHTTIIPHELTASFIADIGNPLLGQLYG 311
Cdd:COG0791   37 ALVAAAAAVLAAAALLAGPAAAVAGAAAPAVGSAGAAAAAAAAKAGSSAAKSAAGASAPPSSTAEAIVAAALSYLGTPYV 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499845637 312 WGGS--FGhRDCSELMKDLFIPFGIWLPRNSQAQIHAWNYIDTTQLLE-DEVYqlmkdkaipFATLIGFKGHIGLYLGmy 388
Cdd:COG0791  117 WGGTspSG-FDCSGLVQYVYRQAGISLPRTSADQAAAGTPVSRSELQPgDLVF---------FRTGGGGISHVGIYLG-- 184

                        170       180       190
                 ....*....|....*....|....*....|..
gi 499845637 389 NNTpaMLHDVWG-----IRTIQSGSEGRHILG 415
Cdd:COG0791  185 NGK--FIHASSSgkgvrISSLDSPYWKSRYVG 214
SH3_7 pfam12914
SH3 domain of SH3b2 type; This domain appears to be an SH3 domain of the SH3b2-type, and is ...
 215-258 9.83e-10

SH3 domain of SH3b2 type; This domain appears to be an SH3 domain of the SH3b2-type, and is the second SH3 domain to be found, downstream of an N-terminal domain that is probably the stabilising domain, for the structure from Swiss:Q72DN3, PDB:3m1u, which is a four-domain protein. The last, the C-terminal region, is the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, pfam00877 (details derived from TOPSAN).


Pssm-ID: 432872  Cd Length: 47  Bit Score: 53.67  E-value: 9.83e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 499845637  215 ISKWFSsLPQAAIIHDNVALNGRSGRHVTTGYLGTVLPIIKSTP 258
Cdd:pfam12914   5 VTIWQN-LPYAAVIRDNVPLYDAKGRFLFTARIGTLLPLLGEDA 47
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 307-396 2.00e-09

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 54.60  E-value: 2.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499845637  307 GQLYGWGGSFG-HRDCSELMKDLFIPFGIWLPRNSQAQIHA-WNYIDTTQLLedevyqlmkdkaipFATLIGFKG----- 379
Cdd:pfam00877   1 GVPYRWGGGSPsGFDCSGLVRYAFAKVGIELPRSSGQQYNAgKKTIPKSEPQ--------------RGDLVFFGTgkgis 66

                          90
                  ....*....|....*..
gi 499845637  380 HIGLYLGmyNNTpaMLH 396
Cdd:pfam00877  67 HVGIYLG--NGQ--MLH 79
PRK13914 PRK13914
invasion associated endopeptidase;
306-386 4.47e-05

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 45.56  E-value: 4.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499845637 306 LGQLYGWGG----SFghrDCSELMKDLFIPFGIWLPRNSQAQihawnYIDTTQLLEDEvyqlmkdkAIPfATLIGFK--- 378
Cdd:PRK13914 377 LGKAYSWGGngptTF---DCSGYTKYVFAKAGISLPRTSGAQ-----YASTTRISESQ--------AKP-GDLVFFDygs 439

                         90
                 ....*....|
gi 499845637 379 --GHIGLYLG 386
Cdd:PRK13914 440 giSHVGIYVG 449
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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