|
Name |
Accession |
Description |
Interval |
E-value |
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
1-820 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 1685.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 1 MQERYDFKAIEAKWQKKWEELKLYEVDDFSEKPKYYCLEMFPYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWD 80
Cdd:COG0495 1 MQERYNPKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDMFPYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 81 AFGLPAENAAIKHGnVHPADWTWDNIANMRRQLKELGISYDWRREIATCHPEYYRWTQWLFLQFYKKGLAYKKKAPVNWC 160
Cdd:COG0495 81 AFGLPAENAAIKNG-VHPAEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWC 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 161 PGCQTVLANEQVIDGECERCHSRVEKKELEQWFFKITAYAERLLQDIKKLTGWPEKVKIMQENWIGRSEGAEITFKIKGH 240
Cdd:COG0495 160 PVDQTVLANEQVIDGRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDGWPEKVKTMQRNWIGRSEGAEVDFPVEGS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 241 EETISVFTTRPDTIFGVTYMVLAPEHPLVEKISRgTQYEKDVLEFKRKMMYLSEIERTAETAEKEGVFTGAYAINPFTGE 320
Cdd:COG0495 240 DEKITVFTTRPDTLFGATFMVLAPEHPLVKELAT-PEQNAAVAAFIEEAKKKSEIERTSETKEKTGVFTGLYAINPLTGE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 321 EIPILLANYVLVEYGTGAVMGVPAHDQRDFLFAKKYNLPIKVVITPPGQElKAEELTEAYTGEGILVNSGEFTGLANKEA 400
Cdd:COG0495 319 KIPIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGD-DPDILEEAYTGDGVLINSGEFDGLDSEEA 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 401 IRIITQEAEKRGFGKYRVNYRLRDWLISRQRYWGAPIPVLYCEKCGIVPVPEDQLPVVLPYNVEFRPTGESPLKYVPEFL 480
Cdd:COG0495 398 KEAIIEWLEEKGLGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQLPVELPEDVDFDPTGGSPLARAPEWV 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 481 NATCPECGGPATRETDTMDTFICSSWYYYRYTSPRDKQQPWSKEKVERWLPVDQYIGGVEHAILHLLYSRFFTKVLYDLG 560
Cdd:COG0495 478 NVTCPKCGGPARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANYWLPVDQYIGGIEHAILHLLYARFFTKVLRDLG 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 561 LVHVDEPFTNLLTQGMVL---KDG------AKMSKSKGNVVSPEEIVEKYGADTARLFILFAAPPERDLEWSDQGVEGSF 631
Cdd:COG0495 558 LVSFDEPFKRLLTQGMVLevgKDGvviggiEKMSKSKGNVVDPDEIIEKYGADTLRLFEMFAGPPERDLEWSDSGVEGAY 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 632 RFLNRVWRLIYQTKDRISDELREFSAKDKELNRLLHATIKKVTEDIeERFNFNTAISAIMELVNGLYQYKE-GEINPGLL 710
Cdd:COG0495 638 RFLNRVWRLVVDEAEALKLDVADLSEADKELRRALHKTIKKVTEDI-ERLRFNTAIAALMELVNALYKAKDsGEADRAVL 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 711 KEALNKLVILLAPFAPHIAEELWEALGNKQSVHLEKWPEYDEEALITEEVEIVIQVNGKVKDRVMVPRNAAEDELKEIAL 790
Cdd:COG0495 717 REALETLVLLLAPFAPHIAEELWERLGHEGSVADAPWPEADEAALVEDEVTIVVQVNGKVRGKIEVPADASKEELEAAAL 796
|
810 820 830
....*....|....*....|....*....|
gi 499662596 791 NTPKIKELTADKKIIKVIIVPEKLINIVVA 820
Cdd:COG0495 797 ADEKVQKFLEGKTIRKVIVVPGKLVNIVVK 826
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
5-820 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 1249.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 5 YDFKAIEAKWQKKWEELKLYEVDDFSEKPKYYCLEMFPYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFGL 84
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 85 PAENAAIKHGNvHPADWTWDNIANMRRQLKELGISYDWRREIATCHPEYYRWTQWLFLQFYKKGLAYKKKAPVNWCPGCQ 164
Cdd:TIGR00396 81 PAENAAIKRGI-HPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 165 TVLANEQVI-DGECERCHSRVEKKELEQWFFKITAYAERLLQDIKKLTGWPEKVKIMQENWIGRSEGAEITFKIKGHEET 243
Cdd:TIGR00396 160 TVLANEQVDsDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDHWPESVKEMQRNWIGKSEGVEITFKIADHDEK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 244 ISVFTTRPDTIFGVTYMVLAPEHPLVEKIsrgTQYEKDVLEFKRKMMYLSEIERTAETAEKEGVFTGAYAINPFTGEEIP 323
Cdd:TIGR00396 240 ITVFTTRPDTIFGVTYLALAPEHPLVEKA---AENNPKVAAFIKKILNKTVAERTKATKEKKGVDTGIKAIHPLTGEKIP 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 324 ILLANYVLVEYGTGAVMGVPAHDQRDFLFAKKYNLPIKVVITPPGQELKaeeLTEAYTGEGILVNSGEFTGLANKEAIRI 403
Cdd:TIGR00396 317 IWVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKDLS---LTAAYTEDGVLVNSGEFNGLNSSEARNA 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 404 ITQEAEKRGFGKYRVNYRLRDWLISRQRYWGAPIPVLYCEKCGIVPVPEDQLPVVLPYNVEFRPTGESPLKYVPEFLNAT 483
Cdd:TIGR00396 394 IIDMLEKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGDGGSPLSRIPEWVNVT 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 484 CPECGGPATRETDTMDTFICSSWYYYRYTSPRDKQQPWSKEKVERWLPVDQYIGGVEHAILHLLYSRFFTKVLYDLGLVH 563
Cdd:TIGR00396 474 CPSCGKPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVN 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 564 VDEPFTNLLTQGMVLK--------------------------------DGAKMSKSKGNVVSPEEIVEKYGADTARLFIL 611
Cdd:TIGR00396 554 TKEPFKKLINQGMVLGfyyppngkvpadvlterdekgkdkaggelvyvGYEKMSKSKGNGIDPQEIVESYGADALRLFIM 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 612 FAAPPERDLEWSDQGVEGSFRFLNRVWRLIYQ---TKDRISDELREFSAKDKELNRLLHATIKKVTEDIEERFNFNTAIS 688
Cdd:TIGR00396 634 FMGPIAASLEWNESGLEGARRFLDRVWNLVYEitgELDAASLTVTALEEAQKELRRDVHKFLKKVTEDLEKRESFNTAIS 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 689 AIMELVNGLYQYKEGEInpglLKEALNKLVILLAPFAPHIAEELWEALGNKQS-VHLEKWPEYDEEALITEEVEIVIQVN 767
Cdd:TIGR00396 714 AMMELLNKLYKAKKEAL----MLEYLKGFVTVLSPFAPHLAEELWEKLGSEPFiIDNAKWPVVDETALVEDKTLIVVQVN 789
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|...
gi 499662596 768 GKVKDRVMVPRNAAEDELKEIALNTPKIKELTADKKIIKVIIVPEKLINIVVA 820
Cdd:TIGR00396 790 GKFRAKITVPKDADEEQVEELAKQDPEVKKYLENKTIKKVIYVPGKLVNFVIK 842
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
5-819 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 974.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 5 YDFKAIEAKWQKKWEELKLYEVDDF--SEKPKYYCLEMFPYPSGK-LHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDA 81
Cdd:PLN02563 80 YPFHEIEPKWQRYWEENRTFRTPDDvdTSKPKFYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDA 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 82 FGLPAENAAIKHGNvHPADWTWDNIANMRRQLKELGISYDWRREIATCHPEYYRWTQWLFLQFYKKGLAYKKKAPVNWCP 161
Cdd:PLN02563 160 FGLPAEQYAIETGT-HPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCP 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 162 GCQTVLANEQVIDGECERCHSRVEKKELEQWFFKITAYAERLLQDIKKLTgWPEKVKIMQENWIGRSEGAEITFKI---- 237
Cdd:PLN02563 239 ALGTVLANEEVVDGLSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDLD-WPESIKEMQRNWIGRSEGAELDFSVldge 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 238 -KGHEETISVFTTRPDTIFGVTYMVLAPEHPLVEKISRGTQyEKDVLEFKRKMMYLSEIERTAETAEKEGVFTGAYAINP 316
Cdd:PLN02563 318 gKERDEKITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQ-KEAVEEYVDAASRKSDLERTELQKEKTGVFTGSYAINP 396
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 317 FTGEEIPILLANYVLVEYGTGAVMGVPAHDQRDFLFAKKYNLPIKVVITPPGQELKAEELteAYTGEGILVNSGE----F 392
Cdd:PLN02563 397 ATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADGNEDDAEK--AYTGEGVIVNSSSsgldI 474
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 393 TGLANKEAIRIITQEAEKRGFGKYRVNYRLRDWLISRQRYWGAPIPVLYCEKCG-IVPVPEDQLPVVLPYNVEFRP--TG 469
Cdd:PLN02563 475 NGLSSKEAAKKVIEWLEETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFLEDSGePVPVPESDLPLTLPELDDFTPtgTG 554
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 470 ESPLKYVPEFLNATCPECGGPATRETDTMDTFICSSWYYYRYTSPRDKQQPWSKEKVERWLPVDQYIGGVEHAILHLLYS 549
Cdd:PLN02563 555 EPPLAKAVSWVNTVDPSSGKPARRETNTMPQWAGSCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYA 634
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 550 RFFTKVLYDLGLVHVDEPFTNLLTQGMVL----------KDGA------------------------------------- 582
Cdd:PLN02563 635 RFWHKVLYDIGVVSTKEPFQCLVNQGMILgeveytafkdSDGEyvsadtadrlgelqqekipeekviksgdsfvlkddps 714
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 583 --------KMSKSKGNVVSPEEIVEKYGADTARLFILFAAPPERDLEWSDQGVEGSFRFLNRVWRLI---------YQTK 645
Cdd:PLN02563 715 irliarahKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRFLGRTWRLVvgaplpdgsFRDG 794
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 646 DRISDElrefsAKDKELNRLLHATIKKVTEDIEErFNFNTAISAIMELVNGLYQYKEgeinpgLLKEALNKLVILLAPFA 725
Cdd:PLN02563 795 TVVTDE-----EPSLEQLRLLHKCIAKVTEEIES-TRFNTAISAMMEFTNAAYKWDK------VPREAIEPFVLLLSPYA 862
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 726 PHIAEELWEALGNKQSVHLEKWPEYDEEALITEEVEIVIQVNGKVKDRVMVPRNAAEDELKEIALNTPKIKELTADKKII 805
Cdd:PLN02563 863 PHLAEELWFRLGHSNSLAYEPWPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGCSEDDAFALASQDEKLSKYLDGKEIK 942
|
890
....*....|....
gi 499662596 806 KVIIVPEKLINIVV 819
Cdd:PLN02563 943 KRIYVPGKILNVIL 956
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
34-622 |
8.22e-133 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 397.77 E-value: 8.22e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 34 KYYCLEMFPYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFGLPAENAAIKHGNvHPADWTWDNIANMRRQL 113
Cdd:cd00812 1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGR-DPEDWTEYNIKKMKEQL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 114 KELGISYDWRREIATCHPEYYRWTQWLFLQFYKKGLAYKKKAPVNWCpgcqtvlaneqvidgecerchsrvekKELEQWF 193
Cdd:cd00812 80 KRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC--------------------------KLLDQWF 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 194 FKITayaerllqdikkLTGWPEKVKIMQENWigrsegaeitfkikgheetisvfTTRPDTIfgvtymvlapehplvekis 273
Cdd:cd00812 134 LKYS------------ETEWKEKLLKDLEKL-----------------------DGWPEEV------------------- 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 274 rgtqyekdvlefkRKMMylseiertaetaekegvftgayainpftgeeipillanyvlveygtgavmgvpahdqrdflfa 353
Cdd:cd00812 160 -------------RAMQ--------------------------------------------------------------- 163
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 354 kkynlpikvvitppgqelkaeelteaytgegilvnsgeftglankeairiitqeaekrgfgkyrvnyrlRDWL-ISRQRY 432
Cdd:cd00812 164 ---------------------------------------------------------------------ENWIgCSRQRY 174
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 433 WGAPIPVlycekcgivpvpedqlpvvlpynvefrptgesplkyvpeflnatcpecggpatreTDTMDTFICSSWYYYRYT 512
Cdd:cd00812 175 WGTPIPW-------------------------------------------------------TDTMESLSDSTWYYARYT 199
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 513 SPRDKQQPW------SKEKVERWLPVDQYIGGVEHAILHLLYSRFFTKVLYDLGLVHvDEPFTNLLTQGMVLKDGAKMSK 586
Cdd:cd00812 200 DAHNLEQPYegdlefDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLVT-DEPPKGLIVQGMVLLEGEKMSK 278
|
570 580 590
....*....|....*....|....*....|....*.
gi 499662596 587 SKGNVVSPEEIVEKYGADTARLFILFAAPPERDLEW 622
Cdd:cd00812 279 SKGNVVTPDEAIKKYGADAARLYILFAAPPDADFDW 314
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-810 |
4.41e-123 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 389.17 E-value: 4.41e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 1 MQERYDFKAIEAKWQKKWEELKLYEVDDFSEKPKYYCLEMFPYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWD 80
Cdd:PRK13208 6 LPKKYDPEELEEKWQKIWEEEGTYKFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 81 AFGLPAENAAIKHGNVHPAD------------WTWDNIANMRRQLKELGISYDWRREIATCHPEYYRWTQWLFLQFYKKG 148
Cdd:PRK13208 86 DNGLPTERKVEKYYGIRKDDisreefielcreLTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 149 LAYKKKAPVNWCPGCQTVLAneqviDGEcerchsrVEKKELEqwffkiTAYaerllqdikkltgwpekvkimqenwigrs 228
Cdd:PRK13208 166 LIYRAEAPVLWCPRCETAIA-----QAE-------VEYRERE------GKL----------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 229 egAEITFKIKGHEE-TISvfTTRPDTIfGVTYMVLApeHPlvekisrgtqyekdvlefkrkmmylsEIERTAEtaekegv 307
Cdd:PRK13208 199 --NYIKFPVEDGEEiEIA--TTRPELL-PACVAVVV--HP--------------------------DDERYKH------- 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 308 FTGAYAINPFTGEEIPILLANYVLVEYGTGAVM----GvpahDQRDFLFAKKYNLPIKVVITPPGqelkaeELTEAYtge 383
Cdd:PRK13208 239 LVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMictfG----DKTDVTWWRELNLPTRIIIDEDG------RMTEAA--- 305
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 384 gilvnsGEFTGLANKEAIRIITQEAEKRGF-GK-----YRVN-------------------------------------- 419
Cdd:PRK13208 306 ------GKLAGLTIEEARKKIVEDLKSGGLlGKqepikHNVKfcercdtpleilvtrqwfikvldlkeellergkeinwy 379
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 420 ---YRLR----------DWLISRQRYWGAPIPVLYCEKCG-IVPVPEDQLPVvlpynvefRPTGESPLKYvpeflnaTCP 485
Cdd:PRK13208 380 pehMRVRlenwieglnwDWCISRQRYFGTPIPVWYCKDCGhPILPDEEDLPV--------DPTKDEPPGY-------KCP 444
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 486 ECG-GPATRETDTMDTFICSS---WYYYRYTSPrdkqqpwsKEKVERWLPVD---QyiGgveHAILH--LLYSRFFTKVL 556
Cdd:PRK13208 445 QCGsPGFEGETDVMDTWATSSitpLIVTGWERD--------EDLFEKVFPMDlrpQ--G---HDIIRtwLFYTILRAYLL 511
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 557 YDlglvhvDEPFTNLLTQGMVL-KDGAKMSKSKGNVVSPEEIVEKYGADTARLFILFAAPPErDLEWSDQGVEGSFRFLN 635
Cdd:PRK13208 512 TG------KLPWKNIMISGMVLdPDGKKMSKSKGNVVTPEELLEKYGADAVRYWAASARLGS-DTPFDEKQVKIGRRLLT 584
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 636 RVW---RLIYQTKDRISDELRE-FSAKDKELNRLLHATIKKVTEDIEErFNFNTAISAIM------------ELVNG-LY 698
Cdd:PRK13208 585 KLWnasRFVLHFSADPEPDKAEvLEPLDRWILAKLAKVVEKATEALEN-YDFAKALEEIEsffwhvfcddylELVKSrAY 663
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 699 QYKEGEINPG---LLKEALNKLVILLAPFAPHIAEELWEALGNKqSVHLEKWPEYDEEAL---ITEEVEIVIQVNGKVK- 771
Cdd:PRK13208 664 GEDEEEEQKSaryTLYTVLDTLLRLLAPFLPFITEEVWSWLYGG-SVHRASWPEPDEELIdeeDEELGELAKEILSAVRk 742
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*...
gi 499662596 772 -------------DRVMVPRNAAEDELKEI------ALNTPKIKELTADKKIIKVIIV 810
Cdd:PRK13208 743 ykseaglslnaplKKVEVYGPADLELLEAAeedlkaAGNIEELELVEGDPELEVEIIA 800
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
1-813 |
1.54e-122 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 389.80 E-value: 1.54e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 1 MQERYDFKAIEAKWQKKWEELKLYEVDDFSEKPKYyCLEMFP-YPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGW 79
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPPF-CIDIPPpNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 80 DAFGLPAEN-----AAIKHGNVHPA----------DWTWDNIANMRRQLKELGISYDWRREIATCHPEYYRWTQWLFLQF 144
Cdd:TIGR00422 80 DHAGIATQVkvekkLGAEGKTKHDLgreefrekiwEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 145 YKKGLAYKKKAPVNWCPGCQTVLANEQVidgecerchsrvEKKELEQ--WFFKitayaerllqdikkltgwpekvkimqe 222
Cdd:TIGR00422 160 YEKGLIYRGEYLVNWDPKLNTAISDIEV------------EYKEVKGklYYIR--------------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 223 nwigrsegaeitFKIK-GHEETISVFTTRPDTIFGVTYMVLAPEHplvekisrgtqyekdvlefkrkmmylseiERTAEt 301
Cdd:TIGR00422 201 ------------YPLAnGSKDYLVVATTRPETMFGDTAVAVHPED-----------------------------ERYKH- 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 302 aekegvFTGAYAINPFTGEEIPILLANYVLVEYGTGAVMGVPAHDQRDFLFAKKYNLPIKVVITPPGqelkaeELTEayt 381
Cdd:TIGR00422 239 ------LIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDG------LLNE--- 303
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 382 gegilvNSGEFTGLANKEAIRIITQEAEKRGF------------------------------------------------ 413
Cdd:TIGR00422 304 ------NAGKYQGLTRFEARKKIVEDLKEEGLlvkiephthnvgtcwrsgtvvepllskqwfvkvekladkaleaaeege 377
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 414 -----GKYRVNYR-----LRDWLISRQRYWGAPIPVLYCEKCGIVPVPEDQLPVVLPYNvefrptgespLKYVPEFlnat 483
Cdd:TIGR00422 378 ikfvpKRMEKRYLnwlrnIKDWCISRQLIWGHRIPVWYCKECGEVYVAKEEPLPDDKTN----------TGPSVEL---- 443
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 484 cpecggpaTRETDTMDT--------FICSSWyyyrytsprdkqqPWSKEKVERWLPVDQYIGGveHAILH------LLYS 549
Cdd:TIGR00422 444 --------EQDTDVLDTwfssslwpFSTLGW-------------PDETKDLKKFYPTDLLVTG--YDIIFfwvarmIFRS 500
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 550 RFFTKVLydlglvhvdePFTNLLTQGMVL-KDGAKMSKSKGNVVSPEEIVEKYGADTARLFILFAAPPERDLEWSDQGVE 628
Cdd:TIGR00422 501 LALTGQV----------PFKEVYIHGLVRdEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDWKRVE 570
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 629 GSFRFLNRVWRLIYQTKDRISDELrEFSAKDKELNRL-------LHATIKKVTEDIEErFNFNTAISAIMELVNGLY--- 698
Cdd:TIGR00422 571 SARNFLNKLWNASRFVLMNLSDDL-ELSGGEEKLSLAdrwilskLNRTIKEVRKALDK-YRFAEAAKALYEFIWNDFcdw 648
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 699 -----QYKEGEINPGLLKEA-------LNKLVILLAPFAPHIAEELWEALGNK-QSVHLEKWPEYDEEALITEE------ 759
Cdd:TIGR00422 649 yielvKYRLYNGNEAEKKAArdtlyyvLDKALRLLHPFMPFITEEIWQHFKEGaDSIMLQSYPVVDAEFVDEEAekafel 728
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499662596 760 -VEIVIQVNgKVKDRVMVPRNA---------AEDELKEIALNTPKIKELTadkKIIKVIIVPEK 813
Cdd:TIGR00422 729 lKEIIVSIR-NLKAESNIPPNAplkvlliytEAETAERLKLNAVDIKGAI---NFSEVEVVIEK 788
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
222-409 |
5.26e-110 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 333.74 E-value: 5.26e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 222 ENWIGRSEGAEITFKIKGHEETISVFTTRPDTIFGVTYMVLAPEHPLVEKISrgtQYEKDVLEFKRKMMYLSEIERTAET 301
Cdd:pfam13603 1 RNWIGRSEGAEITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKLA---EKNPEVAAFIEECKNTSEIERTSET 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 302 AEKEGVFTGAYAINPFTGEEIPILLANYVLVEYGTGAVMGVPAHDQRDFLFAKKYNLPIKVVITPPGQELKAEELTEAYT 381
Cdd:pfam13603 78 KEKEGVFTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPEDGDLDLDIMTEAYT 157
|
170 180
....*....|....*....|....*...
gi 499662596 382 GEGILVNSGEFTGLANKEAIRIITQEAE 409
Cdd:pfam13603 158 EEGILVNSGEFDGLDSEEAKEAIIKKLE 185
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
3-786 |
2.15e-87 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 295.82 E-value: 2.15e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 3 ERYDFKAIEAKWQKKWEELKLYE--VDDFSEKPKYYCLEMFPYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWD 80
Cdd:TIGR00392 4 MRGNLSKREEKILAFWQENDIFEkvKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 81 AFGLPAENAAIKHGNVHPAD----------------WTWDNIANMRRQLKELGISYDWRREIATCHPEYYRWTQWLFLQF 144
Cdd:TIGR00392 84 THGLPIEHKVEKKLGISGKKeissleieefrekcreFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFKEA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 145 YKKGLAYKKKAPVNWCPGCQTVLANEQVIDGECERCHsrvekkeleqwffkitayaerllqdikkltgwpekvkimqenw 224
Cdd:TIGR00392 164 HEKGLLYRGLKPVYWSPRCRTALAEAEVEYKENYKDV------------------------------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 225 igRSEGAEITFKIKGHEET--------ISVFTTRPDTIFGVTYMVLAP--EHPLVEKISRGTQY--EKDVLE-FKRKMMY 291
Cdd:TIGR00392 201 --KDPSIYVKFPVKKDKKTylkvklssLLIWTTTPWTLPSNLAIAVHPdfEYALVQDNTKVEYFilAKKLVEkLYNKAGS 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 292 LSEIERTAETAEKEGVftgaYAINPF------TGEEIPILL-ANYVLVEYGTGAVMGVPAHDQRDFLFAKKYNLPIKVVI 364
Cdd:TIGR00392 279 DYEIIKTFKGSDLEGL----EYEHPLydfvsqLKEGAPVVIgGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVLSPV 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 365 TPPG----QELKAEELTEAYTGEGI----------------LVNSGEFT------------------------------- 393
Cdd:TIGR00392 355 DEKGvyteGVNDFQGRFVKDADKDIikankiiieqlkdkglLLKAEKIThsyphcwrtktpviyrateqwfiktkdikdq 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 394 GLANKEAIRIITQEAEKRgFGKYRVNyrLRDWLISRQRYWGAPIPVLYCEKCGIVPVPEdqlpvVLPYNVE-FRPTGE-- 470
Cdd:TIGR00392 435 MLEQIKKVNWVPEWGEGR-FGNWLEN--RPDWCISRQRYWGIPIPIWYCEDTGEPIVVG-----SIEELIElIELKGIda 506
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 471 SPLKYVPEFLNA--TCPECGGPATRETDTMDTFICS--SWY---YYRYTSprdkqqpwskEKVERWLPVDQYIGGVEHai 543
Cdd:TIGR00392 507 WFEDLHRDFLDKitLKSGDGGEYRRVPDVLDVWFDSgsMPYasiHYPFEN----------EKFKEVFPADFILEGSDQ-- 574
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 544 lhllySR--FFTKVLydLGLVHVDE-PFTNLLTQGMVL-KDGAKMSKSKGNVVSPEEIVEKYGADTARLFILFAAPPErD 619
Cdd:TIGR00392 575 -----TRgwFYSSLA--IGTALFGQaPYKNVITHGFTLdEKGRKMSKSLGNVVDPLKVINKYGADILRLYVASSDPWE-D 646
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 620 LEWSDQGV----EGSFRFLNRVWR--LIYQTKDRISDELREFS-AKDKELNR-LLH---ATIKKVTEDIEErFNFNTAIS 688
Cdd:TIGR00392 647 LRFSDEILkqvvEKYRKIRWNTYRflLTYANLDKFDPLFNSVAvEKFPEEDRwILSrlnSLVEEVNEALEK-YNFHKVLR 725
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 689 AIMELVN----GLY-------QYKEGEINPGL-----LKEALNKLVILLAPFAPHIAEELWEAL---GNKQSVHLEKWPE 749
Cdd:TIGR00392 726 ALQDFIVeelsNWYiriirdrLYCEAKDNDKRaaqttLYYALLTLVRLLAPFLPHTAEEIYQNLpggEEEESVHLNLWPE 805
|
890 900 910
....*....|....*....|....*....|....*..
gi 499662596 750 YDEEAlITEEVEIVIQVNGKVKDRVMVPRNAAEDELK 786
Cdd:TIGR00392 806 VDEEF-IDEALEANMAIVREIVEAFLALRDAANKKLR 841
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
4-766 |
1.06e-86 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 295.07 E-value: 1.06e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 4 RYDFKAIEAKWQKKWEELKLYE--VDDFSEKPKYYclemF----PYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPM 77
Cdd:COG0060 15 RANLPKREPEILKFWEENDIYEksREARAGRPKFV----LhdgpPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 78 GWDAFGLPAENAAIK-HG-------NVHPA-------DWTWDNIANMRRQLKELGISYDWRREIATCHPEYYR--WtqWL 140
Cdd:COG0060 91 GWDCHGLPIELKVEKeLGikkkdieKVGIAefrekcrEYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEEsiW--WA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 141 FLQFYKKGLAYKKKAPVNWCPGCQTVLANeqvidgecercHsrvekkELEqwffkitaYaerllQDIKKLTGWpekVKim 220
Cdd:COG0060 169 LKKLYEKGLLYKGLKPVPWCPRCGTALAE-----------A------EVE--------Y-----KDVTSPSIY---VK-- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 221 qenwigrsegaeitFKIKG-----HEETISV--FTTRPDTI---FGVTYmvlapeHP-----LVEKISRGTQY-EKDVLE 284
Cdd:COG0060 214 --------------FPVKDekallLLEDAYLviWTTTPWTLpanLAVAV------HPdidyvLVEVTGGERLIlAEALVE 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 285 --FKRKMMYLSEIERTAETAEKEGV-FTGAYAINPFTGEEIPILLANYVLVEYGTGAVMGVPAHDQRDFLFAKKYNLPIK 361
Cdd:COG0060 274 avLKELGIEDYEVLATFKGAELEGLrYEHPFYYVVGYDRAHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVL 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 362 VVITPPGQelkaeelteaYTGEGilvnsGEFTGLANKEAIRIITQEAEKRG----FGKYRVNY----------------- 420
Cdd:COG0060 354 NPVDDDGR----------FTEEA-----PLFAGLFVKDANPAIIEDLKERGallaREKITHSYphcwrcktpliyratpq 418
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 421 ----------------------------RL-------RDWLISRQRYWGAPIPVLYCEKCGivpvpEDQLPVVLPYNVE- 464
Cdd:COG0060 419 wfismdklrdraleaiekvnwipewgegRFgnmlenrPDWCISRQRYWGVPIPIWVCEDCG-----ELHRTEEVIGSVAe 493
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 465 -FR-----PTGESPLK--YVPEFLnaTCPECGGPATRETDTMDTFICSSwyyyryTSPrdkqqpWS--KEKVERWLPVDQ 534
Cdd:COG0060 494 lLEeegadAWFELDLHrpFLDETL--KCPKCGGTMRRVPDVLDVWFDSG------SMH------FAvlENREELHFPADF 559
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 535 YIGGV-EHailhllysR--FFTK-----VLYDlglvhvDEPFTNLLTQGMVL-KDGAKMSKSKGNVVSPEEIVEKYGADT 605
Cdd:COG0060 560 YLEGSdQT--------RgwFYSSlltstALFG------RAPYKNVLTHGFVLdEDGRKMSKSLGNVVDPQEVIDKYGADI 625
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 606 ARLFILfAAPPERDLEWSDQGVEGSFRFLNRVWRLIY----------QTKDRISDELREfsakdkELNR----LLHATIK 671
Cdd:COG0060 626 LRLWVA-SSDYWGDLRFSDEILKEVRDVYRRLRNTYRfllanlddfdPAEDAVPYEDLP------ELDRwilsRLNELIK 698
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 672 KVTEDIEErFNFNTAISAIMELVN----GLY-------QYKEGEINPG------LLKEALNKLVILLAPFAPHIAEELWE 734
Cdd:COG0060 699 EVTEAYDN-YDFHRAYRALHNFCVedlsNWYldiskdrLYTEAADSLDrraaqtTLYEVLETLVRLLAPILPFTAEEIWQ 777
|
890 900 910
....*....|....*....|....*....|....*..
gi 499662596 735 AL--GNKQSVHLEKWPEYDEEAL---ITEEVEIVIQV 766
Cdd:COG0060 778 NLpgEAEESVHLADWPEVDEELIdeeLEAKWDLVREV 814
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
48-765 |
1.84e-84 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 288.31 E-value: 1.84e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 48 LHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFGLP----AEnaAIKHG---------NVH--PADWTW-----DNIA 107
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPilgiAE--RIARGdpetielykSLYgiPEEELEkfkdpEYIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 108 N-----MRRQLKELGISYDWRREIATCHPEYYRWTQWLFLQFYKKGLAYKKKAPVNWCPGCQTVLANEQVIDGEcerchs 182
Cdd:PRK12300 79 EyfseeAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDGE------ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 183 rveKKELEQWFFkitayaerllqdikkltgwpekvkimqenwigrsegaeITFKiKGHEETISVFTTRPDTIFGVTYMVL 262
Cdd:PRK12300 153 ---EPEIVEYTL--------------------------------------IKFE-ESEDLILPAATLRPETIFGVTNLWV 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 263 APE--HPLVEK------ISRGTqYEKdvLEFKRKMMylsEIERTAETAEkegvFTGAYAINPFTGEEIPILLANYVLVEY 334
Cdd:PRK12300 191 NPDatYVKAEVdgekwiVSKEA-AEK--LSFQDRDV---EIIEEIKGSE----LIGKKVKNPVTGKEVPILPADFVDPDN 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 335 GTGAVMGVPAHDQRDF-----LFAKKYNL----PIKVVITP-----PGQEL------------KAEELT-EAYTGE---G 384
Cdd:PRK12300 261 GTGVVMSVPAHAPYDYvalrdLKKNKELLdviePIPLIEVEgygefPAKEVveklgiksqedpELEEATkEVYRAEfhkG 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 385 IL-VNSGEFTGLANKEAIRIITQEAEKRGFG------------------------------------------------- 414
Cdd:PRK12300 341 VLkENTGEYAGKPVREAREKITKDLIEKGIAdimyefsnrpvycrcgtecvvkvvkdqwfidysdpewkelahkaldnme 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 415 ----KYRVNYR-----LRDWLISRQRYWGAPIP----------------------VLYCEKCGIVPvpeDQLpvvlpyNV 463
Cdd:PRK12300 421 iipeEYRKEFEntidwLKDRACARRRGLGTRLPwdeewiieslsdstiymayytiAHKIREYGIKP---EQL------TP 491
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 464 EFrptgespLKYVpeFLNATCPE----CGGPATRETDTMdtficsswyyyrytsprdkqqpwsKEKVERWLPVDQYIGGV 539
Cdd:PRK12300 492 EF-------FDYV--FLGKGDPEevskKTGIPKEILEEM------------------------REEFLYWYPVDWRHSGK 538
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 540 EHAILHLLYSRF-----FTKVLYDLGLVhvdepftnllTQGMVLKDGAKMSKSKGNVVSPEEIVEKYGADTARLFILFAA 614
Cdd:PRK12300 539 DLIPNHLTFFIFnhvaiFPEEKWPRGIV----------VNGFVLLEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSA 608
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 615 PPERDLEWSDQGVEGSFRFLNRVWRLIYQTKDRISDElrEFSAKDKELNRLLHATIKKVTEDIEErFNFNTAI-SAIMEL 693
Cdd:PRK12300 609 ELLQDADWREKEVESVRRQLERFYELAKELIEIGGEE--ELRFIDKWLLSRLNRIIKETTEAMES-FQTRDAVqEAFYEL 685
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499662596 694 VNGLYQYKE--GEINPGLLKEALNKLVILLAPFAPHIAEELWEALGNKQSVHLEKWPEYDEEaLITEEVEIVIQ 765
Cdd:PRK12300 686 LNDLRWYLRrvGEANNKVLREVLEIWIRLLAPFTPHLAEELWHKLGGEGFVSLEKWPEPDES-KIDEEAELAEE 758
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
1-766 |
3.13e-81 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 278.91 E-value: 3.13e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 1 MQERYDFKAIEAKWQKKWEELKLYEVDDFSEKPkyYCLeMFPYP--SGKLHMGHVRNYSIGDVVARYKRMRGYAVL---- 74
Cdd:PRK05729 5 LPKTYDPKEVEAKWYQKWEEKGYFKPDDNSKKP--FSI-VIPPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLwlpg 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 75 -----------------------HPMGWDAFglpaenaaIKHgnVhpadWTW-----DNIanmRRQLKELGISYDWRREI 126
Cdd:PRK05729 82 tdhagiatqmvverqlaaegksrHDLGREKF--------LEK--V----WEWkeesgGTI---TNQLRRLGASCDWSRER 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 127 ATCHPEYYRWTQWLFLQFYKKGLAYKKKAPVNWCPGCQTVLANEQVidgecerchsrvEKKELEQ--WFFKitaYaerll 204
Cdd:PRK05729 145 FTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV------------EYKEVKGklWHIR---Y----- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 205 qdikkltgwpekvkimqenwigrsegaeitfKIKGHEETISVFTTRPDTIFGVTY-MVlapeHPlvekisrgtqyeKDvl 283
Cdd:PRK05729 205 -------------------------------PLADGSDYLVVATTRPETMLGDTAvAV----NP------------ED-- 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 284 efkrkmmylseiERTAEtaekegvFTGAYAINPFTGEEIPILLANYVLVEYGTGAVMGVPAHDQRDFLFAKKYNLPIKVV 363
Cdd:PRK05729 236 ------------ERYKH-------LIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINI 296
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 364 ITPPG----------------------QELKAEEL---TEAY---------TGEGI--------LVNSGEFTGLA----N 397
Cdd:PRK05729 297 MDEDGtinenpgeyqgldrfearkaivADLEELGLlvkIEPHthsvghsdrSGVVIepylsdqwFVKMKPLAKPAleavE 376
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 398 KEAIRIITQEAEKrgfgkyrvNYR-----LRDWLISRQRYWGAPIPVLYCEKCGIVpVPEDQlpvvlpynvefrptgesp 472
Cdd:PRK05729 377 NGEIKFVPERWEK--------TYFhwmenIQDWCISRQLWWGHRIPAWYDEDGEVY-VGREE------------------ 429
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 473 lkyvpeflnatcPECGGPA--TRETDTMDT-FicSSWYYyrytsprdkqqPWS-------KEKVERWLPvdqyiggveha 542
Cdd:PRK05729 430 ------------PEAREKAllTQDEDVLDTwF--SSALW-----------PFStlgwpekTEDLKRFYP----------- 473
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 543 ilhllysrffTKVL---YD-----------LGLVHVDE-PFTNLLTQGMVL-KDGAKMSKSKGNVVSPEEIVEKYGADTA 606
Cdd:PRK05729 474 ----------TSVLvtgFDiiffwvarmimMGLHFTGQvPFKDVYIHGLVRdEQGRKMSKSKGNVIDPLDLIDKYGADAL 543
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 607 RLFILFAAPPERDLEWSDQGVEGSFRFLNRVW---RLI-----YQTKDRISDELrEFSAKDKELNRLLHATIKKVTEDIE 678
Cdd:PRK05729 544 RFTLAALASPGRDIRFDEERVEGYRNFANKLWnasRFVlmnleGADVGELPDPE-ELSLADRWILSRLNRTVAEVTEALD 622
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 679 ErFNFNTAISAI------------MELVNGLYQYKEGEINPGLLKEALNKLVILLAPFAPHIAEELWEAL---GNKQSVH 743
Cdd:PRK05729 623 K-YRFDEAARALyefiwnefcdwyLELAKPVLQEAAKRATRATLAYVLEQILRLLHPFMPFITEELWQKLaplGIEESIM 701
|
890 900
....*....|....*....|....*
gi 499662596 744 LEKWPEYDEE--ALITEEVEIVIQV 766
Cdd:PRK05729 702 LAPWPEADEAidEAAEAEFEWLKEL 726
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
1-766 |
2.95e-77 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 268.07 E-value: 2.95e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 1 MQERYDFKAIEAKWQKKWEELKLYEVDDFSEKPKYyCLeMFPYP--SGKLHMGHVRNYSIGDVVARYKRMRGYAVL---- 74
Cdd:COG0525 3 LPKTYDPKEVEAKWYQYWEENGYFKADPDSDKEPF-TI-VIPPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLwqpg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 75 -----------------------HPMGWDAFglpaenaaIKHgnVhpadWTW-----DNIanmRRQLKELGISYDWRREI 126
Cdd:COG0525 81 tdhagiatqavverqlaeegksrHDLGREKF--------LER--V----WEWkeesgGTI---TNQLRRLGASCDWSRER 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 127 ATCHPEYYRWTQWLFLQFYKKGLAYKKKAPVNWCPGCQTVLANEQVIdgecerchSRVEKKELeqWFFKitaYaerllqd 206
Cdd:COG0525 144 FTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVE--------HEEVKGHL--WHIR---Y------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 207 ikkltgwpekvkimqenwigrsegaeitfKIKGHEETISVFTTRPDTIFGVTY-MVlapeHPlvekisrgtqyeKDvlef 285
Cdd:COG0525 204 -----------------------------PLADGSGYIVVATTRPETMLGDTAvAV----HP------------ED---- 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 286 krkmmylseiERTAEtaekegvFTGAYAINPFTGEEIPILLANYVLVEYGTGAVMGVPAHDQRDFLFAKKYNLPIKVVIT 365
Cdd:COG0525 235 ----------ERYKH-------LIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILD 297
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 366 PPG----------------------QELKAEEL---TEAYTgegILVNSGEFTG-----------------LAnKEA--- 400
Cdd:COG0525 298 EDGtinenagkyrgldrfearkaivADLEELGLlvkVEPHK---HSVGHSDRSGtviepylsdqwfvkmkpLA-KPAiea 373
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 401 -----IRIITQEAEKRgfgkyrvnYR-----LRDWLISRQRYWGAPIPVLYCEKcgivpvpedqlpvvlpynvefrptGE 470
Cdd:COG0525 374 vedgeIKFVPERWEKT--------YFhwmenIRDWCISRQLWWGHRIPAWYCPD------------------------GE 421
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 471 SplkYVPEFLNATCPECGGPA-TRETDTMDT-FicSS---------WyyyrytsprdkqqPWSKEKVERWLPvdqyiggv 539
Cdd:COG0525 422 V---YVARTEPEACAKAGSVNlTQDEDVLDTwF--SSalwpfstlgW-------------PEKTEDLKYFYP-------- 475
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 540 ehailhllysrffTKVL---YD-----------LGLVHVDE-PFTNLLTQGMVL-KDGAKMSKSKGNVVSPEEIVEKYGA 603
Cdd:COG0525 476 -------------TSVLvtgFDiiffwvarmimMGLHFTGEvPFKDVYIHGLVRdEQGRKMSKSKGNVIDPLDLIDKYGA 542
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 604 DTARLFILFAAPPERDLEWSDQGVEGSFRFLNRVW---RLIY----QTKDRISDELREFSAKDKE-LNRlLHATIKKVTE 675
Cdd:COG0525 543 DALRFTLAALASPGRDIKFDEERVEGYRNFANKLWnasRFVLmnleGFDPGLDPDPEELSLADRWiLSR-LNKTIAEVTE 621
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 676 DIEErFNFNTAISAI------------MELVNGLYQYKEGEINPG---LLKEALNKLVILLAPFAPHIAEELWEALGNK- 739
Cdd:COG0525 622 ALEK-YRFDEAAQALydfvwnefcdwyLELAKPRLYGGDEAAKREtraTLVYVLEQILRLLHPFMPFITEEIWQKLPPRk 700
|
890 900 910
....*....|....*....|....*....|..
gi 499662596 740 --QSVHLEKWPEYDEEAL---ITEEVEIVIQV 766
Cdd:COG0525 701 egESIMLAPWPEADEELIdeeAEAEFEWLKEV 732
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
13-623 |
4.01e-76 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 258.88 E-value: 4.01e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 13 KWQKKWEELKLYEVDDFSEKPK-YYCLEMFP-YPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFGLPAENA- 89
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKpSFTIHDGPpNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVv 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 90 ----AIKHGNVHPA-----------DWTWDNIANMRRQLKELGISYDWRREIATCHPEYYRWTQWLFLQFYKKGLAYKKK 154
Cdd:pfam00133 81 ekklGIKEKKTRHKygreefrekcrEWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 155 APVNWCPGCQTVLANEQvidgecerchsrVEKKELE--QWFFKitayaerllqdikkltgwpekvkimqenwigrsegae 232
Cdd:pfam00133 161 KLVNWSPALNTALSNLE------------VEYKDVKgpSIHVA------------------------------------- 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 233 itFKIKGHEET-ISVFTTRPDTIFGVTYMVLAPEHPLVeKISRGTQYEKDVLEFKRKMMYLSEIERTAETAEKEGVFtga 311
Cdd:pfam00133 192 --FPLADDEGAsLVIWTTTPWTLPGNTAVAVNPEFDYV-ITGEGYILAEALLKSLYKKGTDKKILEDFRGKELEGKE--- 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 312 yAINPFTGEEIPILLANYVLVEYGTGAVMGVPAHDQRDFLFAKKYNLPIKVVITP-----------PGQELKA--EELTE 378
Cdd:pfam00133 266 -AIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDDdgtfteeapdfQGVYRFDarKKIVE 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 379 AYTGEGILVNSGEFT-------------------------------GLANKEAIRIITQEAEKRgFGKYRVNyrLRDWLI 427
Cdd:pfam00133 345 LLTEKGLLLKIEPFThsypfcwrsgtpiipratpqwfvrmdeladqALEAVEKVQFVPKSGEKR-YFNWLAN--IQDWCI 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 428 SRQRYWGAPIPVLYCEKCGIVPVPEDqlpvvLPYNVEFRPTGESPLKYVPEFLNATCPECGGPATRETDTMDTFICS-SW 506
Cdd:pfam00133 422 SRQRWWGHPIPAWVSKDTEEVVCRGE-----LFELVAGRFEEEGSIKWLHREAKDKLGYGKGTLEQDEDVLDTWFSSgSW 496
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 507 YYYRYTSPRDkqqpwSKEKVERWLPVDQYIGGVEhailhLLYSRFFTKVLYDLGLVHvDEPFTNLLTQGMVL-KDGAKMS 585
Cdd:pfam00133 497 PFSTLGWPFV-----NTEEFKKFFPADMLLEGSD-----QTRGWFYRMIMLSTALTG-SVPFKNVLVHGLVRdEQGRKMS 565
|
650 660 670
....*....|....*....|....*....|....*...
gi 499662596 586 KSKGNVVSPEEIVEKYGADTARLFILFaAPPERDLEWS 623
Cdd:pfam00133 566 KSLGNVIDPLDVIDKYGADALRLWLAN-SDYGRDINLS 602
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
42-620 |
3.02e-64 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 219.81 E-value: 3.02e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 42 PYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFGLPAEN-----AAIKHGNVHPA----------DWTWDNI 106
Cdd:cd00817 10 PNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVvvekkLGIEGKTRHDLgreeflekcwEWKEESG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 107 ANMRRQLKELGISYDWRREIATCHPEYYRWTQWLFLQFYKKGLAYKKKAPVNWCPGCQTVLANEQVidgeCERCHSRVEK 186
Cdd:cd00817 90 GKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----CSRSGDVIEP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 187 KELEQWFFKITAYAERLLQDIKKltgwpEKVKIMQENWigrsegaeitfkikgheetisvfttrpdtifgvtymvlapeh 266
Cdd:cd00817 166 LLKPQWFVKVKDLAKKALEAVKE-----GDIKFVPERM------------------------------------------ 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 267 plvekisrgtqyekdvlefkrKMMYLSEIERtaetaekegvftgayainpftgeeipillanyvlveygtgavmgvpahd 346
Cdd:cd00817 199 ---------------------EKRYENWLEN------------------------------------------------- 208
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 347 qrdflfakkynlpikvvitppgqelkaeelteaytgegilvnsgeftglankeairiitqeaekrgfgkyrvnyrLRDWL 426
Cdd:cd00817 209 ---------------------------------------------------------------------------IRDWC 213
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 427 ISRQRYWGAPIPVLYCEKCGIVPVPEDQLPVVLPYNVEFrptgesplkyvpeflnatCPECGGPA-TRETDTMDTFIcSS 505
Cdd:cd00817 214 ISRQLWWGHRIPAWYCKDGGHWVVAREEDEAIDKAAPEA------------------CVPCGGEElKQDEDVLDTWF-SS 274
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 506 WYYYRYTSPrdkqqpWSKEKV--ERWLPVDQYIGGveHAILhllysrfFTKVLYD--LGLVHVDE-PFTNLLTQGMVL-K 579
Cdd:cd00817 275 SLWPFSTLG------WPEETKdlKKFYPTSLLVTG--HDII-------FFWVARMimRGLKLTGKlPFKEVYLHGLVRdE 339
|
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 499662596 580 DGAKMSKSKGNVVSPEEIVEKYGADTARLFILFAAPPERDL 620
Cdd:cd00817 340 DGRKMSKSLGNVIDPLDVIDGYGADALRFTLASAATQGRDI 380
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
622-736 |
1.13e-53 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 181.26 E-value: 1.13e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 622 WSDQGVEGSFRFLNRVWRLIYQTKDRISDELR--EFSAKDKELNRLLHATIKKVTEDIEeRFNFNTAISAIMELVNGLYQ 699
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWRLVTELAEALAAPAAaaELSEEDKELRRKLHKTIKKVTEDIE-RLRFNTAIAALMELVNALYK 79
|
90 100 110
....*....|....*....|....*....|....*...
gi 499662596 700 YKE-GEINPGLLKEALNKLVILLAPFAPHIAEELWEAL 736
Cdd:cd07958 80 YKKkDAQHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
5-761 |
1.91e-53 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 201.37 E-value: 1.91e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 5 YDFKAIEAKWQKKWEELKLYEVDDF-SEKPKYYCLEMFPYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFG 83
Cdd:PRK14900 19 YEHREVEARWYPFWQERGYFHGDEHdRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 84 LPA----ENAAIKHGNVHPAD----------WTWDNIANMR--RQLKELGISYDWRREIATCHPEYYRWTQWLFLQFYKK 147
Cdd:PRK14900 99 IATqmivEKELKKTEKKSRHDlgreaflervWAWKEQYGSRigEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 148 GLAYKKKAPVNWCPGCQTVLANEQVidgECErchsrvEKKELEQWFFKitayaerllqdikkltgwpekvkimqenwigr 227
Cdd:PRK14900 179 GLIYREKKLINWCPDCRTALSDLEV---EHE------EAHQGELWSFA-------------------------------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 228 segaeitFKIKGHEETISVFTTRPDTIFGVTYMVLAPEHPlvekisrgtQYEKdvlefkrkmmylseiertaetaekegv 307
Cdd:PRK14900 218 -------YPLADGSGEIVVATTRPETMLGDTAVAVHPLDP---------RYMA--------------------------- 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 308 FTGAYAINPFTGEEIPILlANYVLVE--YGTGAVMGVPAHDQRDFLFAKKYNLPIKVVITPPGQelkaeeLTEAytgegi 385
Cdd:PRK14900 255 LHGKKVRHPITGRTFPIV-ADAILVDpkFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGR------MTAE------ 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 386 lvnSGEFTGL----ANKEAIRIITQEAEKRGF------------------------------------------GKYRV- 418
Cdd:PRK14900 322 ---AGPLAGLdrfeARKEVKRLLAEQGLDRGAkphvlplgrcqrsatilepllsdqwyvrieplarpaieaveqGRTRFi 398
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 419 ------NY-----RLRDWLISRQRYWGAPIPVLYCEkcgivpvpeDQLPVVlpynvefrpTGESPlkyvpeflnATCPEC 487
Cdd:PRK14900 399 peqwtnTYmawmrNIHDWCISRQLWWGHQIPAWYCP---------DGHVTV---------ARETP---------EACSTC 451
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 488 GGPATRE-TDTMDTFICSS-WYYYRYTSPRDKqqpwskEKVERWLPVDQYIGGveHAILHLLYSRFFTKVLYDLGlvhvD 565
Cdd:PRK14900 452 GKAELRQdEDVLDTWFSSGlWPFSTMGWPEQT------DTLRTFYPTSVMETG--HDIIFFWVARMMMMGLHFMG----E 519
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 566 EPFTNLLTQGMVLKD-GAKMSKSKGNVVSPEEIVEKYGADTARLFILFAAPPERDLEWSDQGVEGSFRFLNRVWrliyqT 644
Cdd:PRK14900 520 VPFRTVYLHPMVRDEkGQKMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGRDIKLAKERIEGYRAFANKLW-----N 594
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 645 KDRIS-DELREFSAKDKELNRL---------LHATIKKVTEDIE--ERFNFNTAISAI------------MELVNG-LYQ 699
Cdd:PRK14900 595 ASRFAlMNLSGYQERGEDPARLartpadrwiLARLQRAVNETVEalEAFRFNDAANAVyafvwhelcdwyIELAKEaLAS 674
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 700 YKEGEINP--GLLKEALNKLVILLAPFAPHIAEELWEALgnKQSVHLEKWP------EYDEEALITEEVE 761
Cdd:PRK14900 675 EDPEARRSvqAVLVHCLQTSYRLLHPFMPFITEELWHVL--RAQVGASAWAdsvlaaEYPRKGEADEAAE 742
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
1-766 |
3.25e-42 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 166.33 E-value: 3.25e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 1 MQERYDFKAIEAKWQKKWEELKLYEVDDFSEKP----KYYCLEMFPYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHP 76
Cdd:PTZ00419 24 MAASYDPKEVESGWYEWWEKSGFFKPAEDAKSLnsgkKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 77 MGWDAFGLPA----ENAAIKHGNVHPAD----------WTW-DNIANM-RRQLKELGISYDWRREIATCHPEYYRWTQWL 140
Cdd:PTZ00419 104 PGTDHAGIATqvvvEKKLMKEENKTRHDlgreeflkkvWEWkDKHGNNiCNQLRRLGSSLDWSREVFTMDEQRSKAVKEA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 141 FLQFYKKGLAYKKKAPVNWCPGCQTVLAneqviDGECErcHSRVEKKEleqwFFKITAYAERLlqDIKKLTgwpekvkim 220
Cdd:PTZ00419 184 FVRLYEDGLIYRDTRLVNWCCYLKTAIS-----DIEVE--FEEIEKPT----KITIPGYDKKV--EVGVLW--------- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 221 qenwigrsegaEITFKIKGHEET-ISVFTTRPDTIFGVTYMVLapeHPlvekisrgtqyeKDvlefkrkmmylseiERTA 299
Cdd:PTZ00419 242 -----------HFAYPLEDSGQEeIVVATTRIETMLGDVAVAV---HP------------KD--------------ERYK 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 300 EtaekegvFTGAYAINPFT-GEEIPILL-ANYVLVEYGTGAVMGVPAHDQRDFLFAKKYNLPIKVVITPPGQelkaeelt 377
Cdd:PTZ00419 282 K-------LHGKELIHPFIpDRKIPIIAdDELVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGK-------- 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 378 eaytgegILVNSGEFTGLANKEAIRIITQEAEKRGF------GKYR----------VNYRL------------------- 422
Cdd:PTZ00419 347 -------INENGGEFAGMHRFDCRRKIEEELKEMGLlrdkvpNPMRlprcsrsgdiVEPMLipqwyvnckdmakraveav 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 423 -----------------------RDWLISRQRYWGAPIPVLYCEKCGIVPVPEDQLPVVLPYNVEfrptgESPLKYVPEF 479
Cdd:PTZ00419 420 rngelkiipsshenvwyhwleniQDWCISRQLWWGHRIPAYRVISKGPETDPSDEEPWVVARSEE-----EALEKAKKKF 494
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 480 LNatcPECGGPATRETDTMDTFICSS--------WyyyrytsprdkqqPWSKEKVERWLPVDQYIGGveHAILHLLYSRF 551
Cdd:PTZ00419 495 GL---SEEDFELEQDEDVLDTWFSSGlfpfstlgW-------------PDQTDDLQRFFPTSLLETG--SDILFFWVARM 556
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 552 ftkVLydLGLVHVDE-PFTNLLTQGMVL-KDGAKMSKSKGNVVSPEEIVE------------------------------ 599
Cdd:PTZ00419 557 ---VM--MSLHLTDKlPFKTVFLHAMVRdSQGEKMSKSKGNVIDPLEVIEgislqdlnqklyegnlpekeikraielqkk 631
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 600 -------KYGADTARLFILFAAPPERDLEWSDQGVEGSFRFLNRVWR-----LIYQTKDRISDELREFSAKDKE------ 661
Cdd:PTZ00419 632 efpngipECGTDALRFGLLAYTQQGRNINLDINRVVGYRHFCNKLWNavkfaLMKLLKDFNLPNSTLFKPNNVEslpwed 711
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 662 ---LNRlLHATIKKVTEDIEErFNFNTAISAIMELVngLYQ----YKEGeINPGLLKEALNK------LVI--------- 719
Cdd:PTZ00419 712 kwiLHR-LNVAIKEVTEGFKE-YDFSEATQATYNFW--LYElcdvYLEL-IKPRLSKQSDGErkqhaqDVLhtvldiglr 786
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....
gi 499662596 720 LLAPFAPHIAEELWEALGNKQSVH----LEKWPEYD---EEALITEEVEIVIQV 766
Cdd:PTZ00419 787 LLHPMMPFITEELYQRLPNYLRKSesisIAKYPQPNpgwNNEALDEEMKIIMSI 840
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
34-225 |
1.60e-37 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 142.94 E-value: 1.60e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 34 KYYCLEMFPYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFGLPAENAAIKHGNVHPAD------------W 101
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTiwieefredpkeF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 102 TWDNIANMRRQLKELGISYDWRREIATCHPEYYRWTQWLFLQFYKKGLAYKKKAPVnwcpgcqtvlaneqvidgeceRCH 181
Cdd:cd00668 81 VEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPV---------------------RIT 139
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 499662596 182 srvekkelEQWFFKITAYAERLLQDIKKLTGWPEKVKIMQENWI 225
Cdd:cd00668 140 --------EQWFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWL 175
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
5-749 |
1.01e-36 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 148.94 E-value: 1.01e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 5 YDFKAIEAKWqkKWEELKLYEVDDFSEKPKYYCLEMfPYP--SGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAF 82
Cdd:PLN02943 61 FDFTSEERIY--NWWESQGYFKPNFDRGGDPFVIPM-PPPnvTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 83 GLPAE--------NAAIKHGNVHPAD-----WTWD-----NIANmrrQLKELGISYDWRREIATCHPEYYRWTQWLFLQF 144
Cdd:PLN02943 138 GIATQlvvekmlaSEGIKRTDLGRDEftkrvWEWKekyggTITN---QIKRLGASCDWSRERFTLDEQLSRAVVEAFVRL 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 145 YKKGLAYKKKAPVNWCPGCQTVLANEQVidgecerchsrvekkeleqwffkitAYAERllqdikkltgwPEKVKIMQENW 224
Cdd:PLN02943 215 HEKGLIYQGSYMVNWSPNLQTAVSDLEV-------------------------EYSEE-----------PGTLYYIKYRV 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 225 IGrsegaeitfkikGHEETISVFTTRPDTIFGVTYMVLAPEHplvekisrgTQYEKdvlefkrkmmylseiertaetaek 304
Cdd:PLN02943 259 AG------------GSEDFLTIATTRPETLFGDVAIAVNPED---------DRYSK------------------------ 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 305 egvFTGAYAINPFT-GEEIPILLANYVLVEYGTGAVMGVPAHDQRDFLFAKKYNLPIKVVITPPG--------------- 368
Cdd:PLN02943 294 ---YIGKMAIVPMTyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGtlnevaglywfeare 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 369 ---QELKAEELT---EAYT---------GEGI--LVNSGEFTG---LANKE-------AIRIITQEAEKRgFGKYRVNyr 421
Cdd:PLN02943 371 klwSDLEETGLAvkkEPHTlrvprsqrgGEVIepLVSKQWFVTmepLAEKAlkavengELTIIPERFEKI-YNHWLSN-- 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 422 LRDWLISRQRYWGAPIPVLY-----CEKCGIVPVPEDQlpvvlPYNVEFRPTGESPLKYvpeflnatcpecggpatRETD 496
Cdd:PLN02943 448 IKDWCISRQLWWGHRIPVWYivgkdCEEDYIVARSAEE-----ALEKAREKYGKDVEIY-----------------QDPD 505
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 497 TMDTFICSS-WYYYRYTSPRdkqqpWSKEKVERWLPVDQYIGGveHAILHLLYSRFFTKVLYDLGLVhvdePFTNLLTQG 575
Cdd:PLN02943 506 VLDTWFSSAlWPFSTLGWPD-----VSAEDFKKFYPTTVLETG--HDILFFWVARMVMMGIEFTGTV----PFSYVYLHG 574
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 576 MVL-KDGAKMSKSKGNVVSPEEIVEKYGADTARlFILFAAPPERDLEWSDQGVEGSFRFLNRVW---RLIYQTKDRISD- 650
Cdd:PLN02943 575 LIRdSQGRKMSKTLGNVIDPLDTIKEFGTDALR-FTLALGTAGQDLNLSTERLTSNKAFTNKLWnagKFVLQNLPSQSDt 653
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 651 ----ELREFS-AKDKELNRL----------LHATIKKVTEDIEERFnFNTAISAIMELVNGLYQ-----------YKEGE 704
Cdd:PLN02943 654 saweHILACKfDKEESLLSLplpecwvvskLHELIDSVTTSYDKYF-FGDVGREIYDFFWSDFAdwyieasktrlYHSGD 732
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|.
gi 499662596 705 INPGLLKEAL-----NKLVILLAPFAPHIAEELWEALGN-KQSVHLEKWPE 749
Cdd:PLN02943 733 NSALSRAQAVllyvfENILKLLHPFMPFVTEELWQALPYrKEALIVSPWPQ 783
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
11-753 |
2.33e-36 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 148.00 E-value: 2.33e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 11 EAKWQKKWEELKLYE-VDDFSEKPKYYCLEMFPYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFGLPAENA 89
Cdd:PLN02843 9 EPEIQKLWEENQVYKrVSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 90 AIK------HGNVHP-------ADWTWDNIANMRRQLKELGISYDWRREIATCHPEYYRWTQWLFLQFYKKGLAYKKKAP 156
Cdd:PLN02843 89 VLQsldqeaRKELTPiklrakaAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 157 VNWCPGCQTVLAneqviDGECERCHSRVEKkeleqwffkiTAYAerllqdIKKLTGWPEKVkimqenwigrseGAEITFK 236
Cdd:PLN02843 169 VHWSPSSRTALA-----EAELEYPEGHVSK----------SIYV------AFPVVSPSETS------------PEELEEF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 237 IKGheETISVFTTRPDTIFG---------VTYMVLAPEHPLVEKISRGTQYEK---DVLEFKRKMMYLSEIERTAETAEK 304
Cdd:PLN02843 216 LPG--LSLAIWTTTPWTMPAnaavavndkLQYSVVEVQSFSEDESTSGGNKKKrpgNVLKEQQKLFLIVATDLVPALEAK 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 305 EGV-------FTGA------YaINPFTGEEIPILLA-NYVLVEYGTGAVMGVPAHDQRDFLFAKKYNLPIkvvITPPGQE 370
Cdd:PLN02843 294 WGVklvvlktFPGSdlegcrY-IHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPL---LSPVDDA 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 371 LKaeelteaYTGEgilvnSGEFTGLA-----NK-------EAIRIITQEAEKRgfgKYRVNYRLR--------------- 423
Cdd:PLN02843 370 GK-------FTEE-----AGQFSGLSvlgegNAavvealdEAGSLLMEEAYGH---KYPYDWRTKkptifrateqwfasv 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 424 ---------------------------------DWLISRQRYWGAPIPVLYCEKCGIVPVPEDQLPVVLPYnveFRPTGE 470
Cdd:PLN02843 435 egfrqaaldaidkvkwipaqgenriramvsgrsDWCISRQRTWGVPIPVFYHVETKEPLMNEETIAHVKSI---VAQKGS 511
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 471 SPLKY------VPEFLNATCPEcggpATRETDTMDTficssWYyyrytsprDKQQPWS---KEKVERWLPVDQYIGGVEH 541
Cdd:PLN02843 512 DAWWYmdvedlLPEKYRDKASD----YEKGTDTMDV-----WF--------DSGSSWAgvlGSREGLSYPADLYLEGSDQ 574
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 542 ailH--LLYSRFFTKVLYDlGLVhvdePFTNLLTQGMVLKD-GAKMSKSKGNVVSPEEIVE---------KYGADTARLF 609
Cdd:PLN02843 575 ---HrgWFQSSLLTSVATK-GKA----PYKSVLTHGFVLDEkGFKMSKSLGNVVDPRLVIEggknqkqepAYGADVLRLW 646
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 610 I---------LFAAPPERDLEWSDQGVEGSFRFLnrVWRLI-YQTKDRIS-DELREFsakDKELNRLLHATIKKVtEDIE 678
Cdd:PLN02843 647 VasvdytgdvLIGPQILKQMSDIYRKLRGTLRYL--LGNLHdWKPDNAVPyEDLPSI---DKYALFQLENVVNEI-EESY 720
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 679 ERFNFNTAIS-----AIMELVNGLYQ------YKEGEINPG------LLKEALNKLVILLAPFAPHIAEELWEAL----- 736
Cdd:PLN02843 721 DNYQFFKIFQilqrfTIVDLSNFYLDvakdrlYVGGTTSFTrrscqtVLAAHLLSLLRAIAPILPHLAEDAWQNLpfqed 800
|
890
....*....|....*...
gi 499662596 737 -GNKQSVHLEKWPEYDEE 753
Cdd:PLN02843 801 gSAAESVFEAGWPTPNEE 818
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
33-620 |
7.60e-30 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 121.19 E-value: 7.60e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 33 PKYYCLEMFPYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFGLPAENAAIKHG----------------NV 96
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELgisgkkdiekmgiaefNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 97 HPADWTWDNIANMRRQLKELGISYDWRREIATCHPEYYRWTQWLFLQFYKKGLAYKKKAPVNWcPgcqtvlaneqVIdge 176
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW-P----------LI--- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 177 cerchsrveKKELEQWFFKITAYAERLLQDIKKLtgwpekvkimqeNWIgrsegaeitfkikgheetisvfttrpdtifg 256
Cdd:cd00818 147 ---------YRATPQWFIRVTKIKDRLLEANDKV------------NWI------------------------------- 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 257 vtymvlaPEHplvekisrgtqyekdvlefkrkmmylseiertaetaekegvftgayainpftgeeipillanyvlveygt 336
Cdd:cd00818 175 -------PEW---------------------------------------------------------------------- 177
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 337 gavmgvpahdqrdflfakkynlpikvvitppgqelkaeelteaytgegilvnsgeftglankeairiitqeAEKRgFGKY 416
Cdd:cd00818 178 -----------------------------------------------------------------------VKNR-FGNW 185
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 417 RVNyrLRDWLISRQRYWGAPIPVLYCEKCGIVPVpedqlpvvlpynvefrptgesplkyvpeflnatcpecggpaTRETD 496
Cdd:cd00818 186 LEN--RRDWCISRQRYWGTPIPVWYCEDCGEVLV-----------------------------------------RRVPD 222
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 497 TMDTFICS--SWYYyrytsprdkQQ--PWSKEKVERWLPVDQYIGGVEHA-----ILHLLYSRFFTKVlydlglvhvdeP 567
Cdd:cd00818 223 VLDVWFDSgsMPYA---------QLhyPFENEDFEELFPADFILEGSDQTrgwfySLLLLSTALFGKA-----------P 282
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 499662596 568 FTNLLTQGMVL-KDGAKMSKSKGNVVSPEEIVEKYGADTARLFILFAAPPERDL 620
Cdd:cd00818 283 YKNVIVHGFVLdEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVASSDVYAEDL 336
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
42-225 |
9.57e-30 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 124.84 E-value: 9.57e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 42 PYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFGLPAENAAIKHGnVHPADWTwDNIANMRRQL-KELGISY 120
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEG-ITPQELV-DRIHAEFKELfEKLGISF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 121 DwrREIATCHPEYYRWTQWLFLQFYKKGLAYKKKAPVNWCPGCQTVLAnEQVIDGECERCH------------------- 181
Cdd:COG0143 88 D--NFIRTTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECERFLP-DRYVEGTCPKCGaedaygdqcencgatlept 164
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 499662596 182 -----------SRVEKKELEQWFFKITAYAERLLQDIKKLTGWPEKVKIMQENWI 225
Cdd:COG0143 165 elinprsaisgAPPELREEEHYFFRLSKYQDRLLEWIEENPDIQPEVRNEVLSWL 219
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
42-225 |
1.12e-29 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 120.33 E-value: 1.12e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 42 PYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFGLPAENAAIKHGnVHPADWTWDNIANMRRQLKELGISYD 121
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEG-VTPQELCDKYHEIFKDLFKWLNISFD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 122 wrREIATCHPEYYRWTQWLFLQFYKKGLAYKKKAPVNWCPGCQTVLAneqvidgecerchsrvEKKELEQWFFKITAYAE 201
Cdd:cd00814 88 --YFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP----------------EWREEEHYFFRLSKFQD 149
|
170 180
....*....|....*....|....*.
gi 499662596 202 RLLQDIKK--LTGWPEKVKIMQENWI 225
Cdd:cd00814 150 RLLEWLEKnpDFIWPENARNEVLSWL 175
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
41-225 |
4.83e-29 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 120.09 E-value: 4.83e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 41 FPYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFGLPAENAAIKHGnVHPADWTWDNIANMRRQLKELGISY 120
Cdd:pfam09334 7 LPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEG-ITPEELVDRYHEIHREDFKKFNISF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 121 DWRreIATCHPEYYRWTQWLFLQFYKKGLAYKKKAPVNWCPGCQTVLANEQVIdGECERCHS------------------ 182
Cdd:pfam09334 86 DDY--GRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVE-GTCPHCGSedargdqcencgrhlept 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 499662596 183 ------------RVEKKELEQWFFKITAYAERLLQDIKK-LTGWPEKVKIMQENWI 225
Cdd:pfam09334 163 elinpkcvicgtTPEVKETEHYFFDLSKFQDKLREWIEEnNPEWPENVKNMVLEWL 218
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
42-737 |
8.40e-29 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 121.53 E-value: 8.40e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 42 PYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFGLPAENAAIKHGnVHPADWTWDNIANMRRQLKELGISYD 121
Cdd:PRK11893 10 YYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAG-ISPQELADRNSAAFKRLWEALNISYD 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 122 wrREIATCHPEYYRWTQWLFLQFYKKGLAYKKKAPVNWCPGCQTVLANEQVIDGE--CERCHSRVEKKELEQWFFKITAy 199
Cdd:PRK11893 89 --DFIRTTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEEFYTESELIEDGyrCPPTGAPVEWVEEESYFFRLSK- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 200 aerllqdikkltgwpekvkimqenwigrsegaeitfkikgheetisvfttrpdtifgvtymvlapehplvekisrgtqYE 279
Cdd:PRK11893 166 ------------------------------------------------------------------------------YQ 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 280 KDVLEFkrkmmylseiertaetaekegvftgaYAINPftgeeipillanyvlveygtgavmgvpahdqrDFLFakkynlP 359
Cdd:PRK11893 168 DKLLEL--------------------------YEANP--------------------------------DFIQ------P 183
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 360 IKVVitppgqelkaeelteaytgegilvnsgeftglanKEAIRiitqeaekrgFgkyrVNYRLRDWLISRQRY-WGapip 438
Cdd:PRK11893 184 ASRR----------------------------------NEVIS----------F----VKSGLKDLSISRTNFdWG---- 211
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 439 vlycekcgiVPVPEDQLPVVlpynvefrptgesplkYVpeFLNATcpecggpatretdtmdtficsswYYYRYTSPRDKQ 518
Cdd:PRK11893 212 ---------IPVPGDPKHVI----------------YV--WFDAL-----------------------TNYLTALGYPDD 241
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 519 QPWSKEKVERWLPVDQYIGGVEHAILHLLYSRFFtkvLYDLGLvhvdEPFTNLLTQGMVLKDGAKMSKSKGNVVSPEEIV 598
Cdd:PRK11893 242 EELLAELFNKYWPADVHLIGKDILRFHAVYWPAF---LMAAGL----PLPKRVFAHGFLTLDGEKMSKSLGNVIDPFDLV 314
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 599 EKYGADTARLFILFAAPPERDlewsdqgveGSF---RF---------------LNRVWRLIYQTKDRISDELREFSAKDK 660
Cdd:PRK11893 315 DEYGVDAVRYFLLREIPFGQD---------GDFsreAFinrinadlandlgnlAQRTLSMIAKNFDGKVPEPGALTEADE 385
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 661 ELNRLLHATIKKVTEDIEErFNFNTAISAIMELVNGLYQY----------KEgeiNPGLLKEALNKLV-------ILLAP 723
Cdd:PRK11893 386 ALLEAAAALLERVRAAMDN-LAFDKALEAILALVRAANKYideqapwslaKT---DPERLATVLYTLLevlrgiaVLLQP 461
|
730
....*....|....
gi 499662596 724 FAPHIAEELWEALG 737
Cdd:PRK11893 462 VMPELAAKILDQLG 475
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
1-598 |
5.85e-27 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 118.08 E-value: 5.85e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 1 MQERYDFKAIEAKWQKKWEELKLYEVDDFSEKPKYYCLEMFPYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWD 80
Cdd:PLN02381 96 MAKQYSPSAVEKSWYAWWEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVD 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 81 AFGLPA----ENAAIKHGNVHPAD----------WTWDNI--ANMRRQLKELGISYDWRREIATCHPEYYRWTQWLFLQF 144
Cdd:PLN02381 176 HAGIATqvvvEKKLMRERHLTRHDigreefvsevWKWKDEygGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRL 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 145 YKKGLAYKKKAPVNWCPGCQTVLANEQVidgecerchSRVEKKEleqwffkitayaERLLqdikKLTGWPEKVKImqenw 224
Cdd:PLN02381 256 YKEGLIYRDIRLVNWDCTLRTAISDVEV---------DYIDIKE------------RTLL----KVPGYDKPVEF----- 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 225 igrseGAEITFK--IKGHEETISVFTTRPDTIFGVTYMVLAPEHPLVEKISrgtqyekdvlefkrkmmylseiertaeta 302
Cdd:PLN02381 306 -----GVLTSFAypLEGGLGEIVVATTRIETMLGDTAIAIHPDDERYKHLH----------------------------- 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 303 ekegvftGAYAINPFTGEEIPIlLANYVLVE--YGTGAVMGVPAHDQRDFLFAKKYNLPIKVVITPPGQ----------- 369
Cdd:PLN02381 352 -------GKFAVHPFNGRKLPI-ICDAILVDpnFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKinsnggsefag 423
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 370 --ELKAEE-LTEAYTGEGIL---VNSGEFTGLAN----------------------KEAIR-IITQEAEKRGF--GKYRV 418
Cdd:PLN02381 424 mpRFAAREaVIEALQKKGLYrgaKNNEMRLGLCSrtndvvepmikpqwfvncssmaKQALDaAIDGENKKLEFipKQYLA 503
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 419 NYR-----LRDWLISRQRYWGAPIPVLYcekcgiVPVPEDQLPVVLPYN---VEFRPTGESPLKYVPEFLNATCpecggP 490
Cdd:PLN02381 504 EWKrwlenIRDWCISRQLWWGHRIPAWY------VTLEDDQLKELGSYNdhwVVARNESDALLEASQKFPGKKF-----E 572
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 491 ATRETDTMDTFICSSWYyyrytsprdkqqPWSkekVERWlPVDQ------YIGGVEHAILHLLYsrFFTKVLYDLGL-VH 563
Cdd:PLN02381 573 LSQDPDVLDTWFSSGLF------------PLS---VLGW-PDDTddlkafYPTSVLETGHDILF--FWVARMVMMGMqLG 634
|
650 660 670
....*....|....*....|....*....|....*..
gi 499662596 564 VDEPFTNLLTQGMVlKD--GAKMSKSKGNVVSPEEIV 598
Cdd:PLN02381 635 GDVPFRKVYLHPMI-RDahGRKMSKSLGNVIDPLEVI 670
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
659-783 |
1.53e-26 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 105.56 E-value: 1.53e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 659 DKELNRLLHATIKKVTEDIEErFNFNTAISAIMELV-------------NGLYQYKEGEINPGLLKEALNKLVILLAPFA 725
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYEN-YRFNTAAQALYEFFwndlsdwylelikDRLYGEEPDSRAQTTLYEVLETLLRLLAPFM 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499662596 726 PHIAEELWEalgnKQSVHLEKWPE--YDEEALITEEVEI---VIQVNGKVKDRVMVPRNAAED 783
Cdd:pfam08264 80 PFITEELWQ----KESIHLAPWPEdaELEEAELEEAFELrqeIVQAIRKLRSELKIKKSLPLE 138
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
5-800 |
4.08e-23 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 105.96 E-value: 4.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 5 YDFKAIEAKWQKKWEELKLYEVD-DFSE-KPKYYCLEMFPYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAF 82
Cdd:PLN02882 8 FSFPKQEEKILSLWSEIDAFKTQlKRTEgLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCH 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 83 GLPAENAAIKHGNV-HPADWTWDNIAN---------MR------RQLKELGISYDWRREIATCHPEYYRWTQWLFLQFYK 146
Cdd:PLN02882 88 GLPVEYEIDKKLGIkRRDDVLKMGIDKyneecrsivTRyskeweKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFE 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 147 KGLAYKKKAPVNWCPGCQTVLANeqvidgecerchsrvekkeleqwfFKitayAERLLQDIKKltgwPEkvkIMqenwig 226
Cdd:PLN02882 168 KGLVYKGFKVMPYSTACKTPLSN------------------------FE----AGLNYKDVSD----PA---VM------ 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 227 rsegaeITFKIKGHEETISV--FTTRPDTI---------------------FGVTYMV----LAPEHPLVEKISRGTQYE 279
Cdd:PLN02882 207 ------VSFPIVGDPDNASFvaWTTTPWTLpsnlalcvnpnftyvkvrnkyTGKVYIVaesrLSALPTAKPKSKKGSKPE 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 280 K--DVLEFKRKMMYLSEIERTAE------TAEKEGVFTgayainpftgeeipILLANYVLVEYGTGAVMGVPAHDQRDF- 350
Cdd:PLN02882 281 NaaEGYEVLAKVPGSSLVGKKYEplfdyfSEFSDTAFR--------------VVADDYVTDDSGTGVVHCAPAFGEDDYr 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 351 ------LFAKKYNLPIKV--------VITP-PGQELKA--EELTEAYTGEGILVNSGEF-----------TGL------- 395
Cdd:PLN02882 347 vclangIIEKGGNLPVPVdddgcfteKVTDfSGRYVKDadKDIIAAIKAKGRLVKSGSIthsypfcwrsdTPLiyravps 426
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 396 --------------ANKEAIRIITQEAEKRgFGKYRVNyrLRDWLISRQRYWGAPIPVlYCEKCG---IVPVPEDQLP-- 456
Cdd:PLN02882 427 wfvkveeikdrlleNNKQTYWVPDYVKEKR-FHNWLEN--ARDWAVSRSRFWGTPLPI-WISDDGeevVVIGSIAELEkl 502
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 457 ---VVLPYNVEFRPTGESPLKYVPEFlnatcpecgGPATRETDTMDTFICSSWYYYRYTsprdkQQPW-SKEKVERWLPV 532
Cdd:PLN02882 503 sgvKVTDLHRHFIDHITIPSSRGPEF---------GVLRRVDDVFDCWFESGSMPYAYI-----HYPFeNKELFEKNFPA 568
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 533 DQYIGGVEHailhllySR--FFTkvLYDLGLVHVDEP-FTNLLTQGMVL-KDGAKMSKSKGNVVSPEEIVEKYGADTARL 608
Cdd:PLN02882 569 DFVAEGLDQ-------TRgwFYT--LMVLSTALFDKPaFKNLICNGLVLaEDGKKMSKSLKNYPDPNEVIDKYGADALRL 639
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 609 FiLFAAPPER--DLEWSDQGVEGSFR--FLN--RVWRLIYQTKDRISDE-LREFSAKDKE--------LNRLLHAT---- 669
Cdd:PLN02882 640 Y-LINSPVVRaePLRFKEEGVFGVVKdvFLPwyNAYRFLVQNAKRLEVEgGAPFVPLDLAklqnsanvLDRWINSAtqsl 718
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 670 IKKVTEDIEErFNFNTAISAIMELVNGL------YQYK-------EGEINPGL--LKEALNKLVILLAPFAPHIAEELWE 734
Cdd:PLN02882 719 VKFVREEMGA-YRLYTVVPYLVKFIDNLtniyvrFNRKrlkgrtgEEDCRTALstLYNVLLTSCKVMAPFTPFFTEVLYQ 797
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499662596 735 AL-----GNKQSVHLEKWPEYDEealiTEEVEIVIQVNGKVKDRVMVPRNAAEDelKEIALNTPkIKELTA 800
Cdd:PLN02882 798 NLrkvlpGSEESIHYCSFPQVDE----GELDERIEQSVSRMQTVIELARNIRER--HNKPLKTP-LKEMVV 861
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
11-810 |
1.47e-22 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 104.28 E-value: 1.47e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 11 EAKWQKKWEELKLYEV-DDFSEKPKYYCL-EMFPYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFGLPAEN 88
Cdd:PTZ00427 78 EEKVLKYWKSIDAFNTsNKLAKNKKAYIFyDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEY 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 89 AAIKHGNVHPAdwtwDNIANM---------RR-----------QLKELGISYDWRREIATCHPEYYRWTQWLFLQFYKKG 148
Cdd:PTZ00427 158 EIEKENNINKK----EDILKMgidvynekcRGivlkysnewvkTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNN 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 149 LAYKKKAPVNWCPGCQTVLAN-EQVIDGECERCHSRVEKKELEQWFFKITayAERLLQDIKKLTGwpEKVKIM----QEN 223
Cdd:PTZ00427 234 YVYKSFKVMPYSCKCNTPISNfELNLNYKDTPDPSIIISFVLCSDFPKVE--EECNIEEDKQLLG--EKYSVLynnkREN 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 224 WIGRSEGAEITFKIKGHEEtISVFTTRPDTI-------FGVTYMVLAPEHPLVEK--ISRGTQYEKDVLEFKRKMMYLSE 294
Cdd:PTZ00427 310 SNNGNNNSTNNVCYAQHSE-ILAWTTTPWTLpsnlalcVNEHFTYLRIHHVKSNRvvIVGECRLEWIMKELKWNVEDLKI 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 295 IERTAETAEKE----GVFTGAYAINPFTGEEIPILLANYVLVEYGTGAVMGVPAHDQRDFLFAKKYNL--PIKVVITPPG 368
Cdd:PTZ00427 389 VNRFKGKELKGlrykPLFTNFYEKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidPEKNIFIDPL 468
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 369 Q-----ELKAEELTEAYTGEG------------------ILVNSGEFTGLANKEAI-RII----------TQEAEKRGFG 414
Cdd:PTZ00427 469 DangyfTNEVEEVQNLYIKEAdnvikkklknenrllsnnTIVHSYPFCWRSDTPLIyRAIpawfirvsnsTNELVKNNET 548
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 415 KYRVNYRL------------RDWLISRQRYWGAPIPVLYCEKCGIVPVPE-----DQLPVVLPYNVEFR----------P 467
Cdd:PTZ00427 549 TYWIPAHIkekkfhnwikdaKDWCISRNRYWGTPIPIWADEKMETVICVEsikhlEELSGVKNINDLHRhfidhieiknP 628
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 468 TGES--PLKYVPEflnatcpecggpatretdtmdTFICssWYYYRYTSPRDKQQPWS--KEKVERWLPVDQYIGGVEHAi 543
Cdd:PTZ00427 629 KGKTypKLKRIPE---------------------VFDC--WFESGSMPYAKVHYPFSteKEDFHKIFPADFIAEGLDQT- 684
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 544 lhllySRFFTKVLYDLGLVHVDEPFTNLLTQGMVL-KDGAKMSKSKGNVVSPEEIVEKYGADTARLFILFA-APPERDLE 621
Cdd:PTZ00427 685 -----RGWFYTLLVISTLLFDKAPFKNLICNGLVLaSDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSvAVRAENLK 759
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 622 WSDQGVE-----------GSFRFLNR-VWR--------LIYQT-----KDRISDELReFSAKDKeLNRLLHATIK--KVT 674
Cdd:PTZ00427 760 FQEKGVNevvksfilpfyHSFRFFSQeVTRyeclnkkqFLFNTdyiykNDNIMDQWI-FSSVQS-LTKSVHTEMKayKLY 837
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 675 EDIEERFNFntaisaIMELVNGLYQYKEGEINPGLLKE-----------ALNKLVILLAPFAPHIAEELWEALGN----- 738
Cdd:PTZ00427 838 NVLPKLLQF------IENLTNWYIRLNRDRMRGSLGEEnclqslcttyrTLHLFTVLMAPFTPFITEYIYQQLRRvkstn 911
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 739 ---------------------KQSVHLEKWPEYDEEALITEEveiVIQVNGKVKDRVMVPRNAAEdelkeialntpkiKE 797
Cdd:PTZ00427 912 ehnennetgntkegdlnrgviHKSVHFIMLPQVDEKYIIDYE---IIELIEKMKDVILLGRVLRE-------------RR 975
|
970
....*....|...
gi 499662596 798 LTADKKIIKVIIV 810
Cdd:PTZ00427 976 KVASKKPLKSITI 988
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
43-209 |
1.83e-20 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 96.41 E-value: 1.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 43 YPSGKLHMGHVrnYS--IGDVVARYKRMRGYAVLHPMGWDAFGLPAENAAIKHGnVHPADWTwDNIANMRRQL-KELGIS 119
Cdd:PRK12267 14 YPNGKPHIGHA--YTtiAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAG-KTPQEYV-DEISAGFKELwKKLDIS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 120 YDwrREIATCHPEYYRWTQWLFLQFYKKGLAYKKKAPVNWCPGCQTVLANEQVIDGE-CERCHSRVEKKELEQWFFKITA 198
Cdd:PRK12267 90 YD--KFIRTTDERHKKVVQKIFEKLYEQGDIYKGEYEGWYCVSCETFFTESQLVDGGkCPDCGREVELVKEESYFFRMSK 167
|
170
....*....|.
gi 499662596 199 YAERLLQDIKK 209
Cdd:PRK12267 168 YQDRLLEYYEE 178
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
524-806 |
3.75e-19 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 92.17 E-value: 3.75e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 524 EKVERWLPVDQYIGGVE----HAIlhllysrFFTKVLYDLGLvhvdEPFTNLLTQGMVLKDGAKMSKSKGNVVSPEEIVE 599
Cdd:PRK12267 247 ELFKKFWPADVHLVGKDilrfHAI-------YWPIMLMALGL----PLPKKVFAHGWWLMKDGKMSKSKGNVVDPEELVD 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 600 KYGADTARLFILFAAPperdlewsdQGVEGSF-------RF-----------LNRVWRLIYQTKDRISDELREFSAKDKE 661
Cdd:PRK12267 316 RYGLDALRYYLLREVP---------FGSDGDFspealveRInsdlandlgnlLNRTVAMINKYFDGEIPAPGNVTEFDEE 386
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 662 LNRLLHATIKKVTEDIEErFNFNTAISAIMELVNGLYQY----------KEGEINPGL------LKEALNKLVILLAPFA 725
Cdd:PRK12267 387 LIALAEETLKNYEELMEE-LQFSRALEEVWKLISRANKYidetapwvlaKDEGKKERLatvmyhLAESLRKVAVLLSPFM 465
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 726 PHIAEELWEALGnkQSVHLEKWPEYDEEALITEEVEIviqvngkVKDRVMVPRNAAEDELKEI-------ALNTPKIKEL 798
Cdd:PRK12267 466 PETSKKIFEQLG--LEEELTSWESLLEWGGLPAGTKV-------AKGEPLFPRIDVEEEIAYIkeqmegsAPKEPEEKEK 536
|
....*...
gi 499662596 799 TADKKIIK 806
Cdd:PRK12267 537 KPEKPEIT 544
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
630-761 |
9.43e-17 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 79.13 E-value: 9.43e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 630 SFRFLnrvwrLIYQTKDRIsdELREFSAKDKELNRL-------LHATIKKVTEDIEErFNFNTAISAIMELVNGL---Y- 698
Cdd:cd07961 20 AYRFF-----VTYANLDGF--DPGKDDDAVASLNVLdrwilsrLNSLIKEVTEEMEA-YDLYTAVRALLEFIDELtnwYi 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499662596 699 -----QYKEGEINPGL------LKEALNKLVILLAPFAPHIAEELWEAL-----GNKQSVHLEKWPEYDEEaLITEEVE 761
Cdd:cd07961 92 rrnrkRFWGEEGDDDKlaayatLYEVLLTLSRLMAPFTPFITEEIYQNLrrelgDAPESVHLLDWPEVDES-LIDEELE 169
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
575-766 |
1.97e-16 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 82.84 E-value: 1.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 575 GMVLKDGAKMSKSKGNVVSPEEIVEKYGADTARLFILFA---APperdLEWSDQGVEGSFRFLNRvwrlIYQTKDRISDE 651
Cdd:COG0215 257 GFLTVNGEKMSKSLGNFFTVRDLLKKYDPEVLRFFLLSAhyrSP----LDFSEEALEEAEKALER----LYNALRRLEEA 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 652 LREFSAKDKELNRLLHATIKKVTEDieerfnFNT--AISAIMELVNGLYQYKEGEINPGLLKEALNKLVILLapfaphia 729
Cdd:COG0215 329 LGAADSSAEEIEELREEFIAAMDDD------FNTpeALAVLFELVREINKALDEGEDKAALAALAALLRALG-------- 394
|
170 180 190
....*....|....*....|....*....|....*..
gi 499662596 730 eelwEALGNKQSVhLEKWPEYDEEALITEEVEIVIQV 766
Cdd:COG0215 395 ----GVLGLLLLE-PEAWQGAAEDELLDALIEALIEE 426
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
42-225 |
2.05e-16 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 83.66 E-value: 2.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 42 PYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFGLPAENAAIKHGnVHPADWTwDNIANMRRQ-LKELGISY 120
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEG-ITPEELI-ARYHAEHKRdFAGFGISF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 121 D-WRReiaTCHPEYYRWTQWLFLQFYKKGLAYKKKAPVNWCPGCQTVLANEQVIdGECERCHSRV--------------- 184
Cdd:PRK00133 89 DnYGS---THSEENRELAQEIYLKLKENGYIYEKTIEQLYDPEKGMFLPDRFVK-GTCPKCGAEDqygdncevcgatysp 164
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 499662596 185 ---------------EKKELEQWFFKITAYAERLLQDIKKLTGWPEKVKIMQENWI 225
Cdd:PRK00133 165 telinpksaisgatpVLKESEHFFFKLPRFEEFLKEWITRSGELQPNVANKMKEWL 220
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
622-736 |
3.06e-13 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 66.85 E-value: 3.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 622 WSDQGVEGSFRFLNRVWRLIYQTKDRiSDELREFSAKDKELNRLLHATIKKVTEDIEErFNFNTAI-SAIMELVNGLYQY 700
Cdd:cd07959 1 FREEEANSAILRLERFYELAEELIET-EGELEELTFIDRWLLSRLNRLIKETTEAYEN-MQFREALkEGLYELQNDLDWY 78
|
90 100 110
....*....|....*....|....*....|....*....
gi 499662596 701 KE---GEINPGLLKEALNKLVILLAPFAPHIAEELWEAL 736
Cdd:cd07959 79 RErggAGMNKDLLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
569-737 |
2.35e-11 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 67.48 E-value: 2.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 569 TNLLTQGMVLKDGAKMSKSKGNVVSPEEIVEKYGADTARLFILFAAPPER---DLEWSDqgvegsFR------------- 632
Cdd:PRK00133 315 TNVFAHGFLTVEGAKMSKSRGTFIWARTYLDHLDPDYLRYYLAAKLPETIddlDFNWED------FQqrvnselvgkvvn 388
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 633 FLNRVWRLIYQTKD-RISDelrefSAKDKELNRLLHATIKKVTEDIEERfNFNTAISAIMEL---VNGLYQYKE------ 702
Cdd:PRK00133 389 FASRTAGFINKRFDgKLPD-----ALADPELLEEFEAAAEKIAEAYEAR-EFRKALREIMALadfANKYVDDNEpwklak 462
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 499662596 703 ------GEInpglLKEALN---KLVILLAPFAPHIAEELWEALG 737
Cdd:PRK00133 463 qdgerlQAV----CSVGLNlfrALAIYLKPVLPELAERAEAFLN 502
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
622-736 |
5.86e-11 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 61.03 E-value: 5.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 622 WSDQGVEGSFRFLNRVW---RLI---YQTKDRISDELREFSAKDKELNRLLHATIKKVTEDIEErFNFNTAISAI----- 690
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWnaaRFVlmnLEDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALEN-YRFSEAATALyeffw 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 499662596 691 -------MELVNGLYQYKEGEINPG---LLKEALNKLVILLAPFAPHIAEELWEAL 736
Cdd:cd07962 80 ndfcdwyLELVKPRLYGEDEEEKKAaraTLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
9-92 |
1.61e-09 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 61.62 E-value: 1.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 9 AIEAKWQKKWEELKLYEVDDFSEKP----KYYCLEMFPYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFGL 84
Cdd:PLN02959 17 EIEVAVQKWWEEEKVFEAEAGDEPPkpgeKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHCTGM 96
|
....*...
gi 499662596 85 PAENAAIK 92
Cdd:PLN02959 97 PIKASADK 104
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
665-771 |
2.09e-09 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 57.53 E-value: 2.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 665 LLHATIKKVTEDIEErFNFNTAISAIMELVN----GLY-------QYKEGEINP------GLLKEALNKLVILLAPFAPH 727
Cdd:cd07960 52 RLNELIKEVREAYEN-YEFHKVYQALNNFCTvdlsAFYldiikdrLYCDAKDSLerrsaqTVLYHILDALLKLLAPILPF 130
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 499662596 728 IAEELWEALG---NKQSVHLEKWPEYDEEAL---ITEEVEIVIQVNGKVK 771
Cdd:cd07960 131 TAEEVWEHLPgekKEESVFLEDWPELPEEWKdeeLEEKWEKLLALRDEVN 180
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
624-725 |
2.15e-09 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 55.97 E-value: 2.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 624 DQGVEGSFRFLNRVWRLI-----YQTKDRISDELREFSAKDKELNRLLHATIKKVTEDIEErFNFNTAISAIMELVNGLY 698
Cdd:cd07375 1 EERLKQARAFLNRLYRLLsffrkALGGTQPKWDNELLEEADRELLARLQEFIKRTTNALEA-LDPTTAVQELFKFTNELN 79
|
90 100 110
....*....|....*....|....*....|....*...
gi 499662596 699 QYKE-----GEINPG------LLKEALNKLVILLAPFA 725
Cdd:cd07375 80 WYLDelkpaLQTEELreavlaVLRAALVVLTKLLAPFT 117
|
|
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
580-724 |
5.90e-09 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 59.66 E-value: 5.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 580 DGAKMSKSKGNVVSPEEIVEKYGADTARlfILFAAPPERD-LEWSDQG------VEGSFR-FLNRVWRLIyqtKDRISDE 651
Cdd:PTZ00399 312 KGLKMSKSLKNFITIRQALSKYTARQIR--LLFLLHKWDKpMNYSDESmdeaieKDKVFFnFFANVKIKL---RESELTS 386
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499662596 652 LREFSAKDKELNRLLHATIKKVTEDIEERFNFNTAISAIMELVNGLYQYKEGEINP--GLLKEALNKLVILLAPF 724
Cdd:PTZ00399 387 PQKWTQHDFELNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNSGEQPsaPLLRSVAQYVTKILSIF 461
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
633-736 |
9.75e-08 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 51.34 E-value: 9.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 633 FLNRVWRLIYQTKDRISDELREFSAKDKELNRLLHATIKKVTEDIEErFNFNTAISAIMELVNGLYQY----------KE 702
Cdd:cd07957 12 LVNRTLNMASKYFGGVVPEFGGLTEEDEELLEEAEELLEEVAEAMEE-LEFRKALEEIMELARAANKYidetapwklaKE 90
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 499662596 703 GeiNPGLLKEALNKLV-------ILLAPFAPHIAEELWEAL 736
Cdd:cd07957 91 E--DPERLATVLYVLLellrilaILLSPFMPETAEKILDQL 129
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
574-737 |
2.38e-07 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 54.33 E-value: 2.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 574 QGMVLKDGAKMSKSKGNVVSPEEIVEKYGADTARLFILfaappeRDLEWSDQGVEGSFRFL--------NRVWRLIYQTK 645
Cdd:PLN02224 357 HGFLTKDGMKMGKSLGNTLEPFELVQKFGPDAVRYFFL------REVEFGNDGDYSEDRFIkivnahlaNTIGNLLNRTL 430
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 646 DRISDELREFSAKDKEL---NRLLHATIKKVTEDIE---ERFNFNTAISAIMELVNG----------LYQYKEGEINPG- 708
Cdd:PLN02224 431 GLLKKNCESTLVEDSTVaaeGVPLKDTVEKLVEKAQtnyENLSLSSACEAVLEIGNAgntymdqrapWFLFKQGGVSAEe 510
|
170 180 190
....*....|....*....|....*....|....*
gi 499662596 709 ------LLKEALNKLVILLAPFAPHIAEELWEALG 737
Cdd:PLN02224 511 aakdlvIILEVMRVIAVALSPIAPCLSLRIYSQLG 545
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
43-207 |
1.73e-06 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 51.64 E-value: 1.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 43 YPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFGLPAENAAIKHGNVHPADwtWDNIANMRRQL-KELGISYD 121
Cdd:PLN02224 79 YVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSAAANGRNPPEH--CDIISQSYRTLwKDLDIAYD 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 122 wrREIATCHPEYYRWTQWLFLQFYKKGLAYKKKAPVNWCPGCQTVLANEQVIDGECERCHSR--VEKKElEQWFFKITAY 199
Cdd:PLN02224 157 --KFIRTTDPKHEAIVKEFYARVFANGDIYRADYEGLYCVNCEEYKDEKELLENNCCPVHQMpcVARKE-DNYFFALSKY 233
|
....*...
gi 499662596 200 aERLLQDI 207
Cdd:PLN02224 234 -QKPLEDI 240
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
575-611 |
7.35e-06 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 47.57 E-value: 7.35e-06
10 20 30
....*....|....*....|....*....|....*..
gi 499662596 575 GMVLKDGAKMSKSKGNVVSPEEIVEKYGADTARLFIL 611
Cdd:cd00672 166 GHLTIDGEKMSKSLGNFITVRDALKKYDPEVLRLALL 202
|
|
| tRNA-synt_1f |
pfam01921 |
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from ... |
388-618 |
1.13e-04 |
|
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from prokaryotes.
Pssm-ID: 396483 Cd Length: 357 Bit Score: 45.33 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 388 NSGEFTglankEAIRIITQEAEK--RGFGKYRVNYRLRDWLisrqrywgapiPVL-YCEKCGIVpvpeDQLPVVlpynvE 464
Cdd:pfam01921 134 KSGLYD-----EAIKIALENRDEimEILNPYRGEERQETYS-----------PYLpICPKCGRV----LTTPVV-----E 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 465 FRPTGEspLKYVpeflnatCPECGgpatrETDTMDtficsswyyyrYTSPRDKQQpWskeKVE---RW--LPVDQYIGGV 539
Cdd:pfam01921 189 YDEGGT--IRYR-------CDECG-----HEGEVD-----------IRGGNGKLQ-W---KVDwamRWaaLGVDFEPFGK 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 540 EHAIlhllysrffTKVLYDLGLVHVDEPFTNLLTQGMV-----LKDGAKMSKSKGNVVSPEEIVEKYGADTARLFIlFAA 614
Cdd:pfam01921 240 DHAA---------PGGSYDTSSRIADEIFGGEPPEGFPyelilLKGGGKMSSSKGNVITPEDWLEYAPPESLRFLM-FRT 309
|
....
gi 499662596 615 PPER 618
Cdd:pfam01921 310 KPKK 313
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
578-620 |
2.05e-04 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 44.80 E-value: 2.05e-04
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 499662596 578 LKDGAKMSKSKGNVVSPEEIVEKYGADTARLFiLFAAP-PERDL 620
Cdd:PRK00750 275 DKKGEKISKSKGNVITIEDWLEYAPPESLRLF-MFARPkPAKRL 317
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
42-122 |
3.10e-04 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 41.70 E-value: 3.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 42 PYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVLHPMGWDAFGLPAENAAIKHGNVHPAdwtwDNIANMRRQLKELGISYD 121
Cdd:cd00802 6 ITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGGLIGDPANKKGENAKA----FVERWIERIKEDVEYMFL 81
|
.
gi 499662596 122 W 122
Cdd:cd00802 82 Q 82
|
|
| ArgRS_core |
cd00671 |
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic ... |
42-74 |
6.67e-04 |
|
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. There are at least three subgroups of ArgRS. One type contains both characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The second subtype lacks the KMSKS motif; however, it has a lysine N-terminal to the HIGH motif, which serves as the functional counterpart to the second lysine of the KMSKS motif. A third group, which is found primarily in archaea and a few bacteria, lacks both the KMSKS motif and the HIGH loop lysine.
Pssm-ID: 185675 [Multi-domain] Cd Length: 212 Bit Score: 41.78 E-value: 6.67e-04
10 20 30
....*....|....*....|....*....|...
gi 499662596 42 PYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVL 74
Cdd:cd00671 9 ANPTGPLHVGHLRNAIIGDSLARILEFLGYDVT 41
|
|
| PRK12418 |
PRK12418 |
cysteinyl-tRNA synthetase; Provisional |
575-639 |
1.06e-03 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 183518 [Multi-domain] Cd Length: 384 Bit Score: 42.23 E-value: 1.06e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 575 GMVLKDGAKMSKSKGNVVspeeIVEKY---GADTA--RLfILFAAPPERDLEWSDQGVEGSFRFLNRvWR 639
Cdd:PRK12418 253 GMIGLDGEKMSKSRGNLV----FVSRLraaGVDPAaiRL-ALLAGHYRADREWTDAVLAEAEARLAR-WR 316
|
|
| argS |
TIGR00456 |
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed ... |
42-74 |
1.75e-03 |
|
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed genome to date. An interesting feature of the alignment of all arginyl-tRNA synthetases is a fairly deep split between two families. One family includes archaeal, eukaryotic and organellar, spirochete, E. coli, and Synechocystis sp. The second, sharing a deletion of about 25 residues in the central region relative to the first, includes Bacillus subtilis, Aquifex aeolicus, the Mycoplasmas and Mycobacteria, and the Gram-negative bacterium Helicobacter pylori. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273085 [Multi-domain] Cd Length: 563 Bit Score: 41.94 E-value: 1.75e-03
10 20 30
....*....|....*....|....*....|...
gi 499662596 42 PYPSGKLHMGHVRNYSIGDVVARYKRMRGYAVL 74
Cdd:TIGR00456 121 ANPAGPLHVGHLRNAIIGDSLARILEFLGYDVI 153
|
|
| LysS |
COG1384 |
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA ... |
377-611 |
3.02e-03 |
|
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA synthetase, class I is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440994 [Multi-domain] Cd Length: 525 Bit Score: 40.95 E-value: 3.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 377 TEAYTgegilvnSGEF-----TGLANKEAIRIItqeaekrgFGKYRVNYRLRDWlisrqrywgapIPVL-YCEKCGIVpv 450
Cdd:COG1384 139 TELYK-------SGRFdeallRALENYDKIREI--------LLPYLGEERRATY-----------SPFLpICPKCGRV-- 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 451 peDQLPVVlPYNVEfrpTGEspLKYVpeflnatCPECGgpatrETDTMDtficsswyyyrYTSPRDKQQpWskeKVE--- 527
Cdd:COG1384 191 --LQTPVI-EVDAE---AGT--VTYR-------CEGCG-----HEGETP-----------VTGGNGKLQ-W---KVDwam 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 528 RW--LPVDQYIGGVEHAILHL-LYSRFFTKVL---------YDLglvhvdepFTnlltqgmvLKDGAKMSKSKGNVVSPE 595
Cdd:COG1384 236 RWaaLGVDFEPFGKDHAAGSVdSGSKIAREVLggeppegfvYEL--------FL--------DENGEKISKSKGNGLTVE 299
|
250
....*....|....*.
gi 499662596 596 EIVEKYGADTARLFIL 611
Cdd:COG1384 300 EWLEYAEPESLRYFMF 315
|
|
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
42-180 |
4.89e-03 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 40.53 E-value: 4.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 42 PYPSGKLHMGHVrnysIG-----DVVARYKRMRGYAVLHPMGWDAFGLPAENAAI-----------KHGNVHPADWTWdn 105
Cdd:PLN02610 26 PYVNNVPHLGNI----IGcvlsaDVFARYCRLRGYNAIYICGTDEYGTATETKALeenctpkeicdKYHAIHKEVYDW-- 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499662596 106 ianmrrqlkeLGISYDwrREIATCHPEYYRWTQWLFLQFYKKGLAYKKKAPVNWCPGCQTVLANEQVIdGECERC 180
Cdd:PLN02610 100 ----------FDISFD--KFGRTSTPQQTEICQAIFKKLMENNWLSENTMQQLYCDTCQKFLADRLVE-GTCPTE 161
|
|
| LysRS_core_class_I |
cd00674 |
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) ... |
578-640 |
5.60e-03 |
|
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The class I LysRS is found only in archaea and some bacteria and has evolved separately from class II LysRS, as the two do not share structural or sequence similarity.
Pssm-ID: 173900 [Multi-domain] Cd Length: 353 Bit Score: 40.00 E-value: 5.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499662596 578 LKDGAKMSKSKGNVVSPEEIVEKYGADTARLFILFAAPPERDLEWsDQGV---------------------EGSFRFLNR 636
Cdd:cd00674 270 LKGGGKMSSSKGNVITPSDWLEVAPPEVLRYLYARRKNPEKHIGF-DLDIlrlydeydrlerkyygvedaaEKEERELKR 348
|
....
gi 499662596 637 VWRL 640
Cdd:cd00674 349 IYEL 352
|
|
| |
