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MULTISPECIES: GntR family transcriptional regulator [Staphylococcus]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
14-220 2.96e-38

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 132.35  E-value: 2.96e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621648  14 SKGEMIAAEIRLRIVDGKIAPDTLLTENQIAKEYNVSRSPVRDAFKLLKQDQLIHLE-RMGAEVLPFEDKEKKELYDLRI 92
Cdd:COG1802   11 SLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRpNRGARVAPLSPEEIRELYEVRA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621648  93 MLESFAFSR-IKNLNHEQIvKEMRKQLEMMKVAVQFEDAEAFTEHDMKFHEVTIMASKHQYLKTFWNNLRPVMESLILLS 171
Cdd:COG1802   91 ALEGLAARLaAERATPADL-ARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRLS 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 499621648 172 MSKRmnenlEDFERIHHNHEIFIEAIEQQDAKKLNKAFHLNFDDVGEDI 220
Cdd:COG1802  170 LRSP-----GRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERL 213
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
14-220 2.96e-38

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 132.35  E-value: 2.96e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621648  14 SKGEMIAAEIRLRIVDGKIAPDTLLTENQIAKEYNVSRSPVRDAFKLLKQDQLIHLE-RMGAEVLPFEDKEKKELYDLRI 92
Cdd:COG1802   11 SLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRpNRGARVAPLSPEEIRELYEVRA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621648  93 MLESFAFSR-IKNLNHEQIvKEMRKQLEMMKVAVQFEDAEAFTEHDMKFHEVTIMASKHQYLKTFWNNLRPVMESLILLS 171
Cdd:COG1802   91 ALEGLAARLaAERATPADL-ARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRLS 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 499621648 172 MSKRmnenlEDFERIHHNHEIFIEAIEQQDAKKLNKAFHLNFDDVGEDI 220
Cdd:COG1802  170 LRSP-----GRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERL 213
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 86-202 2.71e-16

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 72.02  E-value: 2.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621648   86 ELYDLRIMLESFAFSRIKNLNHEQIVKEMRKQLEMMKVAVQFEDAEAFTEHDMKFHEVTIMASKHQYLKTFWNNLRPVME 165
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 499621648  166 SLILLSMSKRmnenlEDFERIHHNHEIFIEAIEQQDA 202
Cdd:pfam07729  81 RLRRLLLSSP-----GRLRASLEEHRAILDAIRARDP 112
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 86-202 1.79e-12

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 61.99  E-value: 1.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621648    86 ELYDLRIMLESFAFSR-IKNLNHEQIvKEMRKQLEMMKVAVQFEDA-EAFTEHDMKFHEVTIMASKHQYLKTFWNNLRPV 163
Cdd:smart00895   1 ELYEVRRALEPLAARLaAERATDEDL-AALEALLDAMEAAAAAGDDlEEFAELDREFHRALAEAAGNPVLLELLESLRAR 79

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 499621648   164 MESLILLSmskrmnenLEDFERIHHNHEIFIEAIEQQDA 202
Cdd:smart00895  80 LRRLRRLS--------LEAARRALDEHRAILDAIRARDA 110
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 14-67 2.09e-12

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 60.15  E-value: 2.09e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 499621648  14 SKGEMIAAEIRLRIVDGKIAPDTLL-TENQIAKEYNVSRSPVRDAFKLLKQDQLI 67
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLV 55
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 16-212 1.61e-05

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 44.63  E-value: 1.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621648  16 GEMIAAEIRLRIVDGKIAP-DTLLTENQIAKEYNVSRSPVRDAFKLLKQDQLI---HLER-----------------MGA 74
Cdd:PRK03837  15 SEEVEERLEQMIRSGEFGPgDQLPSERELMAFFGVGRPAVREALQALKRKGLVqisHGERarvsrpsadtiigqlsgMAK 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621648  75 EVLPFEDKEKKELYDLRIMLES----FAFSRIKNlnhEQIvKEMRKQLEMMKVAVqfEDAEAFTEHDMKFHEV------- 143
Cdd:PRK03837  95 DFLSQSPDGLAHLKQARLFFESslarYAAEHATD---EQI-ALLRKALERNSQSL--GDNAAFIRSDMEFHRViaeipgn 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499621648 144 TIMASKHQYLKTFWNNLRPVMeslilLSMSKRMNENLEDFERIhhnheifIEAIEQQDAKKLNKAF--HLN 212
Cdd:PRK03837 169 PIFMAIHEALLDWLIEARPEV-----VILHGHENVTLQEHIAI-------VDAIRAHDPDEADRALqsHLN 227
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
14-220 2.96e-38

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 132.35  E-value: 2.96e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621648  14 SKGEMIAAEIRLRIVDGKIAPDTLLTENQIAKEYNVSRSPVRDAFKLLKQDQLIHLE-RMGAEVLPFEDKEKKELYDLRI 92
Cdd:COG1802   11 SLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRpNRGARVAPLSPEEIRELYEVRA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621648  93 MLESFAFSR-IKNLNHEQIvKEMRKQLEMMKVAVQFEDAEAFTEHDMKFHEVTIMASKHQYLKTFWNNLRPVMESLILLS 171
Cdd:COG1802   91 ALEGLAARLaAERATPADL-ARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRLS 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 499621648 172 MSKRmnenlEDFERIHHNHEIFIEAIEQQDAKKLNKAFHLNFDDVGEDI 220
Cdd:COG1802  170 LRSP-----GRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERL 213
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
17-220 3.19e-24

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 95.77  E-value: 3.19e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621648  17 EMIAAEIRLRIVDGKIAP-DTLLTENQIAKEYNVSRSPVRDAFKLLKQDQLIH----------------LERMGAEVLPF 79
Cdd:COG2186   10 EQVAEQLRELILSGELKPgDRLPSERELAEQLGVSRTTVREALRALEALGLVEvrqgggtfvrepspwaLLDPLALLLAL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621648  80 EDKEKKELYDLRIMLES----FAFSRIKnlnhEQIVKEMRKQLEMMKVAVqfEDAEAFTEHDMKFHEVTIMASKHQYLKT 155
Cdd:COG2186   90 DDASLRDLLEARLALEPeaarLAAERAT----DEDLARLEAALAEMEAAA--DDGEAFAEADLAFHRAIAEASGNPLLAL 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499621648 156 FWNNLRPVMESLILLSMSKRmnenlEDFERIHHNHEIFIEAIEQQDAKKLNKAFHLNFDDVGEDI 220
Cdd:COG2186  164 LLESLRELLRRSVRLTLRSP-----EARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERL 223
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 86-202 2.71e-16

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 72.02  E-value: 2.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621648   86 ELYDLRIMLESFAFSRIKNLNHEQIVKEMRKQLEMMKVAVQFEDAEAFTEHDMKFHEVTIMASKHQYLKTFWNNLRPVME 165
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 499621648  166 SLILLSMSKRmnenlEDFERIHHNHEIFIEAIEQQDA 202
Cdd:pfam07729  81 RLRRLLLSSP-----GRLRASLEEHRAILDAIRARDP 112
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 86-202 1.79e-12

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 61.99  E-value: 1.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621648    86 ELYDLRIMLESFAFSR-IKNLNHEQIvKEMRKQLEMMKVAVQFEDA-EAFTEHDMKFHEVTIMASKHQYLKTFWNNLRPV 163
Cdd:smart00895   1 ELYEVRRALEPLAARLaAERATDEDL-AALEALLDAMEAAAAAGDDlEEFAELDREFHRALAEAAGNPVLLELLESLRAR 79

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 499621648   164 MESLILLSmskrmnenLEDFERIHHNHEIFIEAIEQQDA 202
Cdd:smart00895  80 LRRLRRLS--------LEAARRALDEHRAILDAIRARDA 110
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 14-67 2.09e-12

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 60.15  E-value: 2.09e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 499621648  14 SKGEMIAAEIRLRIVDGKIAPDTLL-TENQIAKEYNVSRSPVRDAFKLLKQDQLI 67
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLV 55
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 17-74 1.16e-11

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 58.01  E-value: 1.16e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 499621648   17 EMIAAEIRLRIVDGKIAP-DTLLTENQIAKEYNVSRSPVRDAFKLLKQDQLIHLERMGA 74
Cdd:pfam00392   3 EQVYARLREDILSGRLRPgDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRG 61
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
19-74 1.20e-10

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 55.27  E-value: 1.20e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 499621648    19 IAAEIRLRIVDGKIAP-DTLLTENQIAKEYNVSRSPVRDAFKLLKQDQLIHLERMGA 74
Cdd:smart00345   1 VAERLREDIVSGELRPgDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSG 57
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
19-67 5.21e-09

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 54.48  E-value: 5.21e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 499621648  19 IAAEIRLRIVDGKIAPDTLL-TENQIAKEYNVSRSPVRDAFKLLKQDQLI 67
Cdd:COG2188   10 IADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLL 59
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 16-212 1.61e-05

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 44.63  E-value: 1.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621648  16 GEMIAAEIRLRIVDGKIAP-DTLLTENQIAKEYNVSRSPVRDAFKLLKQDQLI---HLER-----------------MGA 74
Cdd:PRK03837  15 SEEVEERLEQMIRSGEFGPgDQLPSERELMAFFGVGRPAVREALQALKRKGLVqisHGERarvsrpsadtiigqlsgMAK 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621648  75 EVLPFEDKEKKELYDLRIMLES----FAFSRIKNlnhEQIvKEMRKQLEMMKVAVqfEDAEAFTEHDMKFHEV------- 143
Cdd:PRK03837  95 DFLSQSPDGLAHLKQARLFFESslarYAAEHATD---EQI-ALLRKALERNSQSL--GDNAAFIRSDMEFHRViaeipgn 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499621648 144 TIMASKHQYLKTFWNNLRPVMeslilLSMSKRMNENLEDFERIhhnheifIEAIEQQDAKKLNKAF--HLN 212
Cdd:PRK03837 169 PIFMAIHEALLDWLIEARPEV-----VILHGHENVTLQEHIAI-------VDAIRAHDPDEADRALqsHLN 227
PRK09764 PRK09764
GntR family transcriptional regulator;
19-67 2.18e-03

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 38.27  E-value: 2.18e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 499621648  19 IAAEIRLRIVDGKIAP-DTLLTENQIAKEYNVSRSPVRDAFKLLKQDQLI 67
Cdd:PRK09764  10 IADRIREQIARGELKPgDALPTESALQTEFGVSRVTVRQALRQLVEQQIL 59
PRK10225 PRK10225
Uxu operon transcriptional regulator;
19-141 8.37e-03

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 36.54  E-value: 8.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621648  19 IAAEIRLRIVDGKIAP-DTLLTENQIAKEYNVSRSPVRDAFKLLKQDQLIHLER---------------MGAEVLPFEDK 82
Cdd:PRK10225  14 VGAMIRDLIIKTPYNPgERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRgagiyvldssgshntDSPDANVCNDA 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499621648  83 EKKELYDLRIMLESfafsrikNLNHEQIVKEMRKQLEMMKVAVQFEDAEAFTEH-------DMKFH 141
Cdd:PRK10225  94 GPFELLQARQLLES-------NIAEFAALQATREDIVKMRQALQLEERELASSApgssesgDMQFH 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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