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Conserved domains on  [gi|499621315|ref|WP_011302049|]
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SAUGI family uracil-DNA glycosylase inhibitor [Staphylococcus saprophyticus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAUGI pfam06106
S. aureus uracil DNA glycosylase inhibitor; Uracil-DNA glycosylase inhibitors, are DNA mimic ...
 1-112 5.78e-77

S. aureus uracil DNA glycosylase inhibitor; Uracil-DNA glycosylase inhibitors, are DNA mimic proteins that prevent the DNA binding sites of UDGs (Uracil DNA glycosylase) from interacting with their DNA substrate. SSP0047 (or SAUGI; for Staphylococcus aureus uracil-DNA glycosylase inhibitor) acts as a uracil-DNA glycosylase inhibitor that breaks the uracil-removing activity of S. aureus uracil-DNA glycosylase (SAUDG) pfam03167. The SAUGI/SAUDG complex has been determined, and shows that SAUGI binds to the SAUDG DNA binding region via several strong interactions, by using a hydrophobic pocket to hold SAUDG's protruding residue (i.e. SAUDG Leu184, E. coli UDG Leu191 and B. subtilis UDG Phe191). By binding to SAUDG in this way, SAUGI thus prevents SAUDG from binding to its DNA substrate and performing DNA repair activity.


:

Pssm-ID: 428772  Cd Length: 112  Bit Score: 222.22  E-value: 5.78e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621315    1 MTLELQLKHYITNLFNLPRDEKWECESIEEVADDILPDQYVRLGPLSNKILQTNTYYSDTLHKSNIYPFILYYQKQLIAI 80
Cdd:pfam06106   1 MTLELQLKHYITNLFNLPRDEKWECESIEEVADDILPDQYVRLGPLSNKILQTNTYYSDTLHKSNIYPFILYYQKQLIAI 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 499621315   81 GFIDENHDMDFLYLHNTVMPLLDQRYLLTGGQ 112
Cdd:pfam06106  81 GFIDENHDMDFLYLHNTVMPLLDQRYLLTGGQ 112
 
Name Accession Description Interval E-value
SAUGI pfam06106
S. aureus uracil DNA glycosylase inhibitor; Uracil-DNA glycosylase inhibitors, are DNA mimic ...
 1-112 5.78e-77

S. aureus uracil DNA glycosylase inhibitor; Uracil-DNA glycosylase inhibitors, are DNA mimic proteins that prevent the DNA binding sites of UDGs (Uracil DNA glycosylase) from interacting with their DNA substrate. SSP0047 (or SAUGI; for Staphylococcus aureus uracil-DNA glycosylase inhibitor) acts as a uracil-DNA glycosylase inhibitor that breaks the uracil-removing activity of S. aureus uracil-DNA glycosylase (SAUDG) pfam03167. The SAUGI/SAUDG complex has been determined, and shows that SAUGI binds to the SAUDG DNA binding region via several strong interactions, by using a hydrophobic pocket to hold SAUDG's protruding residue (i.e. SAUDG Leu184, E. coli UDG Leu191 and B. subtilis UDG Phe191). By binding to SAUDG in this way, SAUGI thus prevents SAUDG from binding to its DNA substrate and performing DNA repair activity.


Pssm-ID: 428772  Cd Length: 112  Bit Score: 222.22  E-value: 5.78e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621315    1 MTLELQLKHYITNLFNLPRDEKWECESIEEVADDILPDQYVRLGPLSNKILQTNTYYSDTLHKSNIYPFILYYQKQLIAI 80
Cdd:pfam06106   1 MTLELQLKHYITNLFNLPRDEKWECESIEEVADDILPDQYVRLGPLSNKILQTNTYYSDTLHKSNIYPFILYYQKQLIAI 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 499621315   81 GFIDENHDMDFLYLHNTVMPLLDQRYLLTGGQ 112
Cdd:pfam06106  81 GFIDENHDMDFLYLHNTVMPLLDQRYLLTGGQ 112
 
Name Accession Description Interval E-value
SAUGI pfam06106
S. aureus uracil DNA glycosylase inhibitor; Uracil-DNA glycosylase inhibitors, are DNA mimic ...
 1-112 5.78e-77

S. aureus uracil DNA glycosylase inhibitor; Uracil-DNA glycosylase inhibitors, are DNA mimic proteins that prevent the DNA binding sites of UDGs (Uracil DNA glycosylase) from interacting with their DNA substrate. SSP0047 (or SAUGI; for Staphylococcus aureus uracil-DNA glycosylase inhibitor) acts as a uracil-DNA glycosylase inhibitor that breaks the uracil-removing activity of S. aureus uracil-DNA glycosylase (SAUDG) pfam03167. The SAUGI/SAUDG complex has been determined, and shows that SAUGI binds to the SAUDG DNA binding region via several strong interactions, by using a hydrophobic pocket to hold SAUDG's protruding residue (i.e. SAUDG Leu184, E. coli UDG Leu191 and B. subtilis UDG Phe191). By binding to SAUDG in this way, SAUGI thus prevents SAUDG from binding to its DNA substrate and performing DNA repair activity.


Pssm-ID: 428772  Cd Length: 112  Bit Score: 222.22  E-value: 5.78e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499621315    1 MTLELQLKHYITNLFNLPRDEKWECESIEEVADDILPDQYVRLGPLSNKILQTNTYYSDTLHKSNIYPFILYYQKQLIAI 80
Cdd:pfam06106   1 MTLELQLKHYITNLFNLPRDEKWECESIEEVADDILPDQYVRLGPLSNKILQTNTYYSDTLHKSNIYPFILYYQKQLIAI 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 499621315   81 GFIDENHDMDFLYLHNTVMPLLDQRYLLTGGQ 112
Cdd:pfam06106  81 GFIDENHDMDFLYLHNTVMPLLDQRYLLTGGQ 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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