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Conserved domains on  [gi|499594353|ref|WP_011275087|]
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MULTISPECIES: hypothetical protein [Staphylococcus]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 229396)

helix-turn-helix domain-containing protein may bind DNA and be involved in the regulation of gene expression

Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARSR super family cl46857
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 7-116 1.40e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


The actual alignment was detected with superfamily member TIGR01889:

Pssm-ID: 481197  Cd Length: 109  Bit Score: 39.93  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499594353    7 ETLLFYLVFMKAVGEVLKYSYQLKFEQLKTLNEIIKYfHVHHQGVYIDELITYQTISKRQLRHHLEHLYHLGWITKLRDD 86
Cdd:TIGR01889   1 KDLLSLYLYIKSLKRYLKKEFNLSLEELLILYYLGKL-ENNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSE 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 499594353   87 NDQRRLLFLPSNSCQDKLNIMFMEVSEMVK 116
Cdd:TIGR01889  80 DDERKVIISINKEQRSKIESLISEIEQIIK 109
 
Name Accession Description Interval E-value
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 7-116 1.40e-04

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 39.93  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499594353    7 ETLLFYLVFMKAVGEVLKYSYQLKFEQLKTLNEIIKYfHVHHQGVYIDELITYQTISKRQLRHHLEHLYHLGWITKLRDD 86
Cdd:TIGR01889   1 KDLLSLYLYIKSLKRYLKKEFNLSLEELLILYYLGKL-ENNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSE 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 499594353   87 NDQRRLLFLPSNSCQDKLNIMFMEVSEMVK 116
Cdd:TIGR01889  80 DDERKVIISINKEQRSKIESLISEIEQIIK 109
 
Name Accession Description Interval E-value
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 7-116 1.40e-04

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 39.93  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499594353    7 ETLLFYLVFMKAVGEVLKYSYQLKFEQLKTLNEIIKYfHVHHQGVYIDELITYQTISKRQLRHHLEHLYHLGWITKLRDD 86
Cdd:TIGR01889   1 KDLLSLYLYIKSLKRYLKKEFNLSLEELLILYYLGKL-ENNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSE 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 499594353   87 NDQRRLLFLPSNSCQDKLNIMFMEVSEMVK 116
Cdd:TIGR01889  80 DDERKVIISINKEQRSKIESLISEIEQIIK 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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