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Conserved domains on  [gi|499381864|ref|WP_011069435|]
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MULTISPECIES: GtrA family protein [Shigella]

Protein Classification

GtrA family protein( domain architecture ID 10006204)

GtrA family protein is an integral membrane protein that may be involved in the synthesis of cell surface polysaccharides

Gene Ontology:  GO:0000271|GO:0005886|GO:0016020
PubMed:  32060027|26369580

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GtrA COG2246
Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid ...
 6-124 5.63e-09

Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid transport and metabolism];


:

Pssm-ID: 441847  Cd Length: 133  Bit Score: 50.59  E-value: 5.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499381864   6 KLLTSSFFSYFLIGIVNTALHWGVFYACYNNLAFGQGRSNIVGFICAATFSFFANARCSFKVSATK------ARYFIFIF 79
Cdd:COG2246    4 RRLLRQLLRFGLVGGLGTLVDLGVFYLLVELLGLPPLLANVIAFVVAVIVNFLLNRRWTFRSRGGRsrlrefLRFLLVSL 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 499381864  80 FMGAMSY-LFGVLFDLLALSPIFTLFTFSLFSLVLGYCASKYFIFR 124
Cdd:COG2246   84 VGLALNLgLLALLVYVLGLPYLLAKLIGIVVGTVFNFLLSRRWVFR 129
 
Name Accession Description Interval E-value
GtrA COG2246
Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid ...
 6-124 5.63e-09

Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid transport and metabolism];


Pssm-ID: 441847  Cd Length: 133  Bit Score: 50.59  E-value: 5.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499381864   6 KLLTSSFFSYFLIGIVNTALHWGVFYACYNNLAFGQGRSNIVGFICAATFSFFANARCSFKVSATK------ARYFIFIF 79
Cdd:COG2246    4 RRLLRQLLRFGLVGGLGTLVDLGVFYLLVELLGLPPLLANVIAFVVAVIVNFLLNRRWTFRSRGGRsrlrefLRFLLVSL 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 499381864  80 FMGAMSY-LFGVLFDLLALSPIFTLFTFSLFSLVLGYCASKYFIFR 124
Cdd:COG2246   84 VGLALNLgLLALLVYVLGLPYLLAKLIGIVVGTVFNFLLSRRWVFR 129
GtrA pfam04138
GtrA-like protein; Members of this family are predicted to be integral membrane proteins with ...
 15-123 1.98e-06

GtrA-like protein; Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.


Pssm-ID: 427738  Cd Length: 116  Bit Score: 43.31  E-value: 1.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499381864   15 YFLIGIVNTALHWGVFYACYNNLAFGQGRSNIVGFICAATFSFFANARCSFKVSATK-----ARYFIFIFFMGAMSY-LF 88
Cdd:pfam04138   2 FLLVGVLGTLVDLAVFLLLLELFGLSYLLANAIAFVVAILVNFLLNRRWTFRDRRSGslrelLRFFLVSLAGLLLNLlLL 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 499381864   89 GVLFDLLALSPIFTLFTFSLFSLVLGYCASKYFIF 123
Cdd:pfam04138  82 WLLVDGLGLPPLLAKLVGIAVGTVVNFLLSRFFVF 116
 
Name Accession Description Interval E-value
GtrA COG2246
Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid ...
 6-124 5.63e-09

Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid transport and metabolism];


Pssm-ID: 441847  Cd Length: 133  Bit Score: 50.59  E-value: 5.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499381864   6 KLLTSSFFSYFLIGIVNTALHWGVFYACYNNLAFGQGRSNIVGFICAATFSFFANARCSFKVSATK------ARYFIFIF 79
Cdd:COG2246    4 RRLLRQLLRFGLVGGLGTLVDLGVFYLLVELLGLPPLLANVIAFVVAVIVNFLLNRRWTFRSRGGRsrlrefLRFLLVSL 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 499381864  80 FMGAMSY-LFGVLFDLLALSPIFTLFTFSLFSLVLGYCASKYFIFR 124
Cdd:COG2246   84 VGLALNLgLLALLVYVLGLPYLLAKLIGIVVGTVFNFLLSRRWVFR 129
GtrA pfam04138
GtrA-like protein; Members of this family are predicted to be integral membrane proteins with ...
 15-123 1.98e-06

GtrA-like protein; Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.


Pssm-ID: 427738  Cd Length: 116  Bit Score: 43.31  E-value: 1.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499381864   15 YFLIGIVNTALHWGVFYACYNNLAFGQGRSNIVGFICAATFSFFANARCSFKVSATK-----ARYFIFIFFMGAMSY-LF 88
Cdd:pfam04138   2 FLLVGVLGTLVDLAVFLLLLELFGLSYLLANAIAFVVAILVNFLLNRRWTFRDRRSGslrelLRFFLVSLAGLLLNLlLL 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 499381864   89 GVLFDLLALSPIFTLFTFSLFSLVLGYCASKYFIF 123
Cdd:pfam04138  82 WLLVDGLGLPPLLAKLVGIAVGTVVNFLLSRFFVF 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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