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phosphoribosylformylglycinamidine synthase [Bifidobacterium longum]
Protein Classification
phosphoribosylformylglycinamidine synthase ( domain architecture ID 11493214 )
phosphoribosylformylglycinamidine synthase catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
List of domain hits
Name
Accession
Description
Interval
E-value
FGAM-synthase
TIGR01857 phosphoribosylformylglycinamidine synthase, clade II; This model represents a single-molecule ...
3-1242
0e+00
phosphoribosylformylglycinamidine synthase, clade II; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This model represents a second clade of these enzymes found in Clostridia, Bifidobacteria and Streptococcus species. This enzyme performs the fourth step in IMP biosynthesis (the precursor of all purines) from PRPP. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 130916 [Multi-domain]
Cd Length: 1239
Bit Score: 2286.31
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 3 F RV Y VEKK P GFDVE A Q Q L AG ELR TI LGL TG LK A LRIVN R YDV EGISQ ELF DQ TV P T V FSEP QV D N V AYD L PDF A G - AK V F 81
Cdd:TIGR01857 1 K RV F VEKK A GFDVE S Q S L VK ELR HN LGL SS LK D LRIVN V YDV FDLAE ELF AP TV K T I FSEP VT D H V LDE L SVQ A D l AK F F 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 82 A T EFLPGQFDQRADSA A ECI Q L I S QG E RP TV RS AKLY A L E GDL T D ADVDT IK H Y V INPV EA RE AS L E T KET L KTQVPV P G 161
Cdd:TIGR01857 81 A V EFLPGQFDQRADSA Q ECI L L L S ES E DV TV NT AKLY I L N GDL D D EELNK IK N Y Y INPV DS RE KD L T T GKA L EEFSES P K 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 162 K VET IA GF NEM DAE AGQ KF ID E R GLAM D L A DL E F C Q K YF SEES R E PT I TEIKV I DTYWSDHCRHTTF G TEL DE VT ID D -- 239
Cdd:TIGR01857 161 E VET LT GF ESY DAE DLA KF KA E Q GLAM S L E DL K F I Q D YF KSIG R N PT E TEIKV L DTYWSDHCRHTTF E TEL KH VT FS D sk 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 240 -- ATV K A A F E R YLAMR H ELGR DA KPV C LMDM G TI G AK W L K KNG V L TG L DE SEEINAC T V KVK VDV N G HD E D WL FL FKNET 317
Cdd:TIGR01857 241 fq KQL K K A Y E D YLAMR E ELGR SE KPV T LMDM A TI F AK Y L R KNG K L DD L EV SEEINAC S V EIE VDV D G VK E P WL LM FKNET 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 318 HNHPTEIEPFGGAATCIGG C IRDPLSGRSYVYQAMRVTGA A DPTVP V SETL E GKLPQRK LV TTAA A GYSSYGNQIGLATG 397
Cdd:TIGR01857 321 HNHPTEIEPFGGAATCIGG A IRDPLSGRSYVYQAMRVTGA G DPTVP I SETL K GKLPQRK IT TTAA H GYSSYGNQIGLATG 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 398 QV D EIYHPGYVAKRMEVGAVVAATP ADH V R RE T P A PGD K IILLGG R TGRDGIGGATGSSK A H N VESLEL D GAEVQKGNAP 477
Cdd:TIGR01857 401 QV S EIYHPGYVAKRMEVGAVVAATP KEN V V RE K P E PGD V IILLGG K TGRDGIGGATGSSK E H T VESLEL C GAEVQKGNAP 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 478 V ERK L QRLFR R G DAC RLIK R CNDFGAGGVSVA V GELADGL FV DLN T VPKKYEGL D GTELAISESQERMAV D V DA EDVD E F 557
Cdd:TIGR01857 481 E ERK I QRLFR N G NVT RLIK K CNDFGAGGVSVA I GELADGL EI DLN K VPKKYEGL N GTELAISESQERMAV V V SP EDVD A F 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 558 LAY AR EENLEATV I ATVTE D PR M VM T WNG DK IV N LSR E FL AS NG ASKHQTVH V EEQ ---- QSYETPWGEG TL A E RMN K LV 633
Cdd:TIGR01857 561 LAY CN EENLEATV V ATVTE K PR L VM N WNG KT IV D LSR R FL DT NG VRQVIDAK V VDK dvkl PEERQKTSAE TL E E DWL K VL 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 634 T D I NVAS N KGL S ERFDS TI GAGTVLMP F GGK R QLTP NM A M VAKLPV F - GET T TASA M AWGFNPYI MSKNQFT GA YLS V V E 712
Cdd:TIGR01857 641 S D L NVAS Q KGL Q ERFDS SV GAGTVLMP L GGK Y QLTP TE A S VAKLPV L g GET H TASA I AWGFNPYI AEWSPYH GA AYA V I E 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 713 SLAKLVAAG FEHE KA Y LSFQEYFEKL RDEP ERWGKP A AA V LGA LM AQ V DLG AG AIGGKDSMSG S FE D L D VPPTLISFAV A 792
Cdd:TIGR01857 721 SLAKLVAAG ADYK KA R LSFQEYFEKL DKDA ERWGKP F AA L LGA IK AQ I DLG LP AIGGKDSMSG T FE E L T VPPTLISFAV T 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 793 VG N MK R AT SPEFK D A DHR I VR I APRY L A DG l T P D K D A L L E V F SV IEEL TDF H DALAV S TPG YG AT AE A L F KMT L GNRIG V 872
Cdd:TIGR01857 801 TA N SR R VI SPEFK A A GEN I YL I PGQA L E DG - T I D F D L L K E N F AQ IEEL IAD H KVVSA S AVK YG GV AE S L A KMT F GNRIG A 879
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 873 T LN DSI a VD DLFT PA YGSFI V E LADD aklpav SNLVEIGE IG T TT SEY V F K AA GE T LDL DAVQE AWE SGI E S VFP Y rs K G 952
Cdd:TIGR01857 880 E LN NPE - LE DLFT AQ YGSFI F E SPEE ------ LSIANVEK IG Q TT ADF V L K VN GE K LDL EELES AWE GKL E E VFP S -- K F 950
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 953 EDK GA TVE TIDFHAP KK TVYVGSS V A KP H VVIPVFPG N N C EYDSA A AFE RA GA D V TTL I VN NL TPA A VA ES TQAL VDEI N 1032
Cdd:TIGR01857 951 EDK KE TVE VPAVASE KK VIKAKEK V E KP R VVIPVFPG T N S EYDSA K AFE KE GA E V NLV I FR NL NEE A LV ES VETM VDEI D 1030
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1033 KSQI V M I PGGFS G GDEPDGSAKFI T A FF R A P A V TE A VRDL L k N RDGL M LGICNGFQALVK L GL V PYG D I VPMTDAC PTLT 1112
Cdd:TIGR01857 1031 KSQI L M L PGGFS A GDEPDGSAKFI A A IL R N P K V RV A IDSF L - A RDGL I LGICNGFQALVK S GL L PYG N I EAANETS PTLT 1109
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1113 F N T I G RH Q S RL VRTR V AS DL SPWLS KT SVGDIH TVAI SHGEGRFVASDEVLA Q LR A NGQIATQYVD ET G T P G MD LDV NPN 1192
Cdd:TIGR01857 1110 Y N D I N RH V S KI VRTR I AS TN SPWLS GV SVGDIH AIPV SHGEGRFVASDEVLA E LR E NGQIATQYVD FN G K P S MD SKY NPN 1189
1210 1220 1230 1240 1250
....*....|....*....|....*....|....*....|....*....|
gi 499380727 1193 GS L LAIEGITSPDGR V FGKMGHSER S G N GL YV N V PGNK Y Q PI F EA GV E YF 1242
Cdd:TIGR01857 1190 GS S LAIEGITSPDGR I FGKMGHSER Y G D GL FK N I PGNK D Q HL F AS GV K YF 1239
Name
Accession
Description
Interval
E-value
FGAM-synthase
TIGR01857 phosphoribosylformylglycinamidine synthase, clade II; This model represents a single-molecule ...
3-1242
0e+00
phosphoribosylformylglycinamidine synthase, clade II; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This model represents a second clade of these enzymes found in Clostridia, Bifidobacteria and Streptococcus species. This enzyme performs the fourth step in IMP biosynthesis (the precursor of all purines) from PRPP. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 130916 [Multi-domain]
Cd Length: 1239
Bit Score: 2286.31
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 3 F RV Y VEKK P GFDVE A Q Q L AG ELR TI LGL TG LK A LRIVN R YDV EGISQ ELF DQ TV P T V FSEP QV D N V AYD L PDF A G - AK V F 81
Cdd:TIGR01857 1 K RV F VEKK A GFDVE S Q S L VK ELR HN LGL SS LK D LRIVN V YDV FDLAE ELF AP TV K T I FSEP VT D H V LDE L SVQ A D l AK F F 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 82 A T EFLPGQFDQRADSA A ECI Q L I S QG E RP TV RS AKLY A L E GDL T D ADVDT IK H Y V INPV EA RE AS L E T KET L KTQVPV P G 161
Cdd:TIGR01857 81 A V EFLPGQFDQRADSA Q ECI L L L S ES E DV TV NT AKLY I L N GDL D D EELNK IK N Y Y INPV DS RE KD L T T GKA L EEFSES P K 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 162 K VET IA GF NEM DAE AGQ KF ID E R GLAM D L A DL E F C Q K YF SEES R E PT I TEIKV I DTYWSDHCRHTTF G TEL DE VT ID D -- 239
Cdd:TIGR01857 161 E VET LT GF ESY DAE DLA KF KA E Q GLAM S L E DL K F I Q D YF KSIG R N PT E TEIKV L DTYWSDHCRHTTF E TEL KH VT FS D sk 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 240 -- ATV K A A F E R YLAMR H ELGR DA KPV C LMDM G TI G AK W L K KNG V L TG L DE SEEINAC T V KVK VDV N G HD E D WL FL FKNET 317
Cdd:TIGR01857 241 fq KQL K K A Y E D YLAMR E ELGR SE KPV T LMDM A TI F AK Y L R KNG K L DD L EV SEEINAC S V EIE VDV D G VK E P WL LM FKNET 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 318 HNHPTEIEPFGGAATCIGG C IRDPLSGRSYVYQAMRVTGA A DPTVP V SETL E GKLPQRK LV TTAA A GYSSYGNQIGLATG 397
Cdd:TIGR01857 321 HNHPTEIEPFGGAATCIGG A IRDPLSGRSYVYQAMRVTGA G DPTVP I SETL K GKLPQRK IT TTAA H GYSSYGNQIGLATG 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 398 QV D EIYHPGYVAKRMEVGAVVAATP ADH V R RE T P A PGD K IILLGG R TGRDGIGGATGSSK A H N VESLEL D GAEVQKGNAP 477
Cdd:TIGR01857 401 QV S EIYHPGYVAKRMEVGAVVAATP KEN V V RE K P E PGD V IILLGG K TGRDGIGGATGSSK E H T VESLEL C GAEVQKGNAP 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 478 V ERK L QRLFR R G DAC RLIK R CNDFGAGGVSVA V GELADGL FV DLN T VPKKYEGL D GTELAISESQERMAV D V DA EDVD E F 557
Cdd:TIGR01857 481 E ERK I QRLFR N G NVT RLIK K CNDFGAGGVSVA I GELADGL EI DLN K VPKKYEGL N GTELAISESQERMAV V V SP EDVD A F 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 558 LAY AR EENLEATV I ATVTE D PR M VM T WNG DK IV N LSR E FL AS NG ASKHQTVH V EEQ ---- QSYETPWGEG TL A E RMN K LV 633
Cdd:TIGR01857 561 LAY CN EENLEATV V ATVTE K PR L VM N WNG KT IV D LSR R FL DT NG VRQVIDAK V VDK dvkl PEERQKTSAE TL E E DWL K VL 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 634 T D I NVAS N KGL S ERFDS TI GAGTVLMP F GGK R QLTP NM A M VAKLPV F - GET T TASA M AWGFNPYI MSKNQFT GA YLS V V E 712
Cdd:TIGR01857 641 S D L NVAS Q KGL Q ERFDS SV GAGTVLMP L GGK Y QLTP TE A S VAKLPV L g GET H TASA I AWGFNPYI AEWSPYH GA AYA V I E 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 713 SLAKLVAAG FEHE KA Y LSFQEYFEKL RDEP ERWGKP A AA V LGA LM AQ V DLG AG AIGGKDSMSG S FE D L D VPPTLISFAV A 792
Cdd:TIGR01857 721 SLAKLVAAG ADYK KA R LSFQEYFEKL DKDA ERWGKP F AA L LGA IK AQ I DLG LP AIGGKDSMSG T FE E L T VPPTLISFAV T 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 793 VG N MK R AT SPEFK D A DHR I VR I APRY L A DG l T P D K D A L L E V F SV IEEL TDF H DALAV S TPG YG AT AE A L F KMT L GNRIG V 872
Cdd:TIGR01857 801 TA N SR R VI SPEFK A A GEN I YL I PGQA L E DG - T I D F D L L K E N F AQ IEEL IAD H KVVSA S AVK YG GV AE S L A KMT F GNRIG A 879
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 873 T LN DSI a VD DLFT PA YGSFI V E LADD aklpav SNLVEIGE IG T TT SEY V F K AA GE T LDL DAVQE AWE SGI E S VFP Y rs K G 952
Cdd:TIGR01857 880 E LN NPE - LE DLFT AQ YGSFI F E SPEE ------ LSIANVEK IG Q TT ADF V L K VN GE K LDL EELES AWE GKL E E VFP S -- K F 950
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 953 EDK GA TVE TIDFHAP KK TVYVGSS V A KP H VVIPVFPG N N C EYDSA A AFE RA GA D V TTL I VN NL TPA A VA ES TQAL VDEI N 1032
Cdd:TIGR01857 951 EDK KE TVE VPAVASE KK VIKAKEK V E KP R VVIPVFPG T N S EYDSA K AFE KE GA E V NLV I FR NL NEE A LV ES VETM VDEI D 1030
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1033 KSQI V M I PGGFS G GDEPDGSAKFI T A FF R A P A V TE A VRDL L k N RDGL M LGICNGFQALVK L GL V PYG D I VPMTDAC PTLT 1112
Cdd:TIGR01857 1031 KSQI L M L PGGFS A GDEPDGSAKFI A A IL R N P K V RV A IDSF L - A RDGL I LGICNGFQALVK S GL L PYG N I EAANETS PTLT 1109
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1113 F N T I G RH Q S RL VRTR V AS DL SPWLS KT SVGDIH TVAI SHGEGRFVASDEVLA Q LR A NGQIATQYVD ET G T P G MD LDV NPN 1192
Cdd:TIGR01857 1110 Y N D I N RH V S KI VRTR I AS TN SPWLS GV SVGDIH AIPV SHGEGRFVASDEVLA E LR E NGQIATQYVD FN G K P S MD SKY NPN 1189
1210 1220 1230 1240 1250
....*....|....*....|....*....|....*....|....*....|
gi 499380727 1193 GS L LAIEGITSPDGR V FGKMGHSER S G N GL YV N V PGNK Y Q PI F EA GV E YF 1242
Cdd:TIGR01857 1190 GS S LAIEGITSPDGR I FGKMGHSER Y G D GL FK N I PGNK D Q HL F AS GV K YF 1239
PurL_repeat1
cd02203 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. ...
211-592
5.64e-134
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100034 [Multi-domain]
Cd Length: 313
Bit Score: 411.48
E-value: 5.64e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 211 E IKVIDTY WS D HCRH TT F GTE L DEV tiddatvkaaferylamrhelgrdakpvclmdmgtigakwlkkngvltgldesee 290
Cdd:cd02203 1 E LGMFAQM WS E HCRH KS F KSL L KMI ------------------------------------------------------- 25
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 291 inactvkvkvdvnghded W LFL FK N ETHNHP TE IEPFGGAAT CI GG C IRD P LS GRSYVYQAMRVTGAA D PTV P VS E t LE G 370
Cdd:cd02203 26 ------------------ W AVV FK V ETHNHP SA IEPFGGAAT GV GG I IRD I LS MGARPIALLDGLRFG D LDI P GY E - PK G 86
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 371 KL PQ R KLVTTAA AG Y S S YGN Q IG LA T GQVDEIYH P G Y VAKRMEVGAV V AAT P A DH VRR - ET P A PGD KII L L GGRTGRDGI 449
Cdd:cd02203 87 KL SP R RILDGVV AG I S D YGN C IG IP T VGGEVRFD P S Y YGNPLVNVGC V GIV P K DH IVK s KA P G PGD LVV L V GGRTGRDGI 166
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 450 GGAT G SSK AHNVE S L ELD GAE VQ K G NAPV E R KLQ RLFRRGDACR LI KRCN D F GAGG V S V AV G E L A ---- D G LFV DL NT VP 525
Cdd:cd02203 167 GGAT F SSK ELSEN S S ELD RPA VQ V G DPFM E K KLQ EAILEARETG LI VGIQ D L GAGG L S S AV S E M A akgg L G AEI DL DK VP 246
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499380727 526 KKYE G LDGT E LA ISESQERM AVD V DA ED VD EFLA YARE E N LEA T VI AT VT E D P R MVMTWN G DKIVN L 592
Cdd:cd02203 247 LREP G MSPW E IW ISESQERM LLV V PP ED LE EFLA ICKK E D LEA A VI GE VT D D G R LRLYYK G EVVAD L 313
GATase_5
pfam13507 CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not ...
979-1242
2.47e-109
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not found in pfam00310, pfam07685 and pfam13230.
Pssm-ID: 463904 [Multi-domain]
Cd Length: 260
Bit Score: 343.71
E-value: 2.47e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 979 KP H V V I PVF PG N N C EY DS AAAFERAG A D VTTLIVNN L TPAA V aestqalvd EINKS Q IVMI PGGFS G GD EP d GS A K FIT A 1058
Cdd:pfam13507 1 KP R V A I LRE PG T N G EY EM AAAFERAG F D AVDVHMSD L LSGR V --------- SLDDF Q GLAA PGGFS Y GD VL - GS G K GWA A 70
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1059 FFR - A P AVTE A VRDLLKNR D GLM LGICNG F Q A L V KLGL V P Y G DIVPMTD a C PTLT F N TI GR HQ SR L V RTRV a S DL SP WLS 1137
Cdd:pfam13507 71 SIL f N P KLRD A FEAFFNRP D TFS LGICNG C Q L L S KLGL I P G G EGDLAER - W PTLT R N DS GR FE SR W V NVKI - S EK SP SVF 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1138 k TSVG D IHTVAIS HGEGRFV A - S D EVLA Q L R ANGQ I A TQ YVD ET G T P GMDLDV NPNGS L L A I E GI T SPDGRV F G K M G H S E 1216
Cdd:pfam13507 149 - LRGM D GSGLPVA HGEGRFV F r S E EVLA R L E ANGQ V A LR YVD NA G N P TEEYPF NPNGS P L G I A GI C SPDGRV L G L M P H P E 227
250 260 270
....*....|....*....|....*....|...
gi 499380727 1217 R SGNGLYVN - V P G ------ NKYQPI F EAGVEYF 1242
Cdd:pfam13507 228 R VFRPWQWP h W P P geweev SPWLRL F RNARKWV 260
PurL2
COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain ...
980-1243
3.45e-109
Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439817 [Multi-domain]
Cd Length: 236
Bit Score: 342.42
E-value: 3.45e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 980 P H V V I P VFPG N NC EY D S AAAFERAGA DVTTLIVNN L tpaavaestqal VDEINKSQIVMI PGGFS G GD EPDGS A KFI taf 1059
Cdd:COG0047 1 P K V A I L VFPG S NC DR D M AAAFERAGA EAEDVWHSD L ------------ RTDLDDFDGLVL PGGFS Y GD YLRAG A IAA --- 65
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1060 f RA P a VTE AVR DLL k N R D GL M LGICNGFQ A L VK LGL V P y G D ivpmtda C P T LT F N TIG R HQS R L V RT RV ASDL SP WL S KT 1139
Cdd:COG0047 66 - FS P - IMD AVR EFA - R R G GL V LGICNGFQ I L TE LGL L P - G I ------- W P A LT R N RSL R FIC R W V YL RV ENND SP FT S GM 134
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1140 SV G DIHTVA I S HGEGR F VA SD E V LA Q L R ANGQ I A TQ YVD ET G TPGM dl DV NPNGSL LA I E GIT SP DG R V F G K M G H S ER SG 1219
Cdd:COG0047 135 EA G EVIPIP I A HGEGR Y VA DE E T LA E L E ANGQ V A FR YVD AD G NVTY -- PA NPNGSL NN I A GIT NE DG N V L G M M P H P ER AV 212
250 260
....*....|....*....|....
gi 499380727 1220 NG L YVNVPGNKYQP IF EAG V E YF A 1243
Cdd:COG0047 213 EP L LGPGESTDGLR IF RSA V K YF G 236
PRK05297
PRK05297 phosphoribosylformylglycinamidine synthase; Provisional
118-1218
3.23e-61
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 235394 [Multi-domain]
Cd Length: 1290
Bit Score: 230.07
E-value: 3.23e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 118 Y AL E GD L TDADVDTIKHYVINP - V E ARE A S L ETK E T L KTQVP v P GKVETI --- A G FNEMDAE A GQKF ider GLA MDLADL 193
Cdd:PRK05297 109 Y YV E AA L SAEQRAALAALLHDR m T E SVF A D L DDA E A L FSHHE - P KPLTSV dvl G G GRAALEA A NVEL ---- GLA LAEDEI 183
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 194 EFCQKY F SEES R E PT IT E IKVIDTYW S D HCRH TT F GTEL dev TID DA tvkaaferylamrhelgrd AK P VC L MD M ----- 268
Cdd:PRK05297 184 DYLVEA F TKLG R N PT DV E LMMFAQAN S E HCRH KI F NADW --- TID GE ------------------- EQ P KS L FK M iknth 241
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 269 ----- G TIG A kw L K K N - G V LT G ldeseein ACTVKVKV D VNG ----- H D E DWLF L F K N ETHNHPT E I E PF G GAAT CI GG C 337
Cdd:PRK05297 242 etnpd G VLS A -- Y K D N a A V ME G -------- SKVGRFFP D PDT grygy H Q E PAHI L M K V ETHNHPT A I S PF P GAAT GS GG E 311
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 338 IRD --------- P LS G R ----- S Y vyqa M R VT G AAD P T vpvs E TLE GK l P Q R ----- KLVTTAAA G YSSYG N QI G ----- 393
Cdd:PRK05297 312 IRD egatgrgsk P KA G L tgfsv S N ---- L R IP G FEQ P W ---- E EDY GK - P E R iasal DIMIEGPL G GAAFN N EF G rpnll 382
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 394 -------- LATGQVD E IY hp GY VAKR M EV G AVVAAT p ADHV RRETPAP G D K I I L LGG RTG R D G I GG ATG SS K A HNVE S LE 465
Cdd:PRK05297 383 gyfrtfeq KVNSHNE E VR -- GY HKPI M LA G GIGNIR - ADHV QKGEIPV G A K L I V LGG PAM R I G L GG GAA SS M A SGQS S ED 459
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 466 LD G A E VQ K GN APV ER KL Q RLFR R ---- GD A c RL I KRCN D F GAGG V S V A VG EL AD ----- G L F v DL NTV P KKYE G LDGT E L 536
Cdd:PRK05297 460 LD F A S VQ R GN PEM ER RC Q EVID R cwql GD D - NP I LSIH D V GAGG L S N A FP EL VN dggrg G R F - DL RKI P NDEP G MSPL E I 537
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 537 AIS ESQER MAVDVDA ED VDE F L A YARE E NLEAT V IATV TE DPRMVM -- TWNGD K I V N L SREF L ASNGASK H QT V HVEEQQ 614
Cdd:PRK05297 538 WCN ESQER YVLAIAP ED LEL F E A ICER E RCPFA V VGEA TE ERHLTL ed SHFDN K P V D L PLDV L LGKPPKM H RD V KTVKAK 617
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 615 SYETPWGEGT LAE --- R MNK L V T din VAS nkgls ER F DS TIG AGT V lmpf G G krqltpnma M VA K -------- L PV ---- 679
Cdd:PRK05297 618 GPALDYSGID LAE ave R VLR L P T --- VAS ----- KS F LI TIG DRS V ---- T G --------- L VA R dqmvgpwq V PV adca 676
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 680 --------- F GE tttas AMA W G FNPYIMSKNQFTG A YLS V V E S L AKLV AA ------------------ G FEH E K A Y L sfq 732
Cdd:PRK05297 677 vtaasydgy A GE ----- AMA M G ERTPVALLDAAAS A RMA V G E A L TNIA AA pigdlkriklsanwmaaa G HPG E D A R L --- 748
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 733 ey FEKLR deperwgkpaa AV LGA L MAQVDL gag A I - G GKDS M S ------ GSF ED LD V -- P PT LI -- S FA v A V GNMKRATS 801
Cdd:PRK05297 749 -- YDAVK ----------- AV GME L CPALGI --- T I p V GKDS L S mktkwq EGG ED KE V ts P LS LI is A FA - P V EDVRKTLT 811
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 802 P EFK - D A D HRIVR I -------------- A PR Y -- L A D G l T PD - K DA -- L LEV F SV I EE L TD ------ F HD ala V S TP G YG 855
Cdd:PRK05297 812 P QLR t D K D TALLL I dlgrgknrlggsal A QV Y nq L G D K - A PD v D DA ed L KGF F NA I QA L VA egllla Y HD --- R S DG G LL 887
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 856 A T aea L FK M TLGNRI G VTLN - D SIAV D D --- LF TPAY G sf I V ELADD A KLP AV SN - L V E I G ------ E IG TTTS -- EY V F 922
Cdd:PRK05297 888 T T --- L AE M AFAGHC G LDID l D ALGD D A laa LF NEEL G -- A V IQVRA A DRD AV EA i L A E H G lsdcvh V IG KPNA gd RI V I 962
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 923 KAA G E T L --- DLDAVQEA W E ---------- SGI E SV --- F PYRSKGE D K G AT V E - T I D FHAPKKTVYVGSS v A K P H V V I P 985
Cdd:PRK05297 963 TRN G K T V fse SRTELRRW W S etsyqmqrlr DNP E CA dqe F DAILDQA D P G LN V K l T F D PNEDIAAPFIATG - A R P K V A I L 1041
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 986 VFP G N N CEYDS AAAF E RAG A D VTTLIVNN L tpaavaestqa L VDEINKSQIVMIP -- GGFS G GD EPD --- G S AK F I T af F 1060
Cdd:PRK05297 1042 REQ G V N SHVEM AAAF D RAG F D AIDVHMSD L ----------- L AGRVTLEDFKGLV ac GGFS Y GD VLG age G W AK S I L -- F 1108
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1061 R apavt EAV RD LLK --- N R - D GLM LG I CNG F Q ALVK L G lvpyg D I V P MTDAC P TLTF N TIGRHQS R LVRTR V ASDL S PW L 1136
Cdd:PRK05297 1109 N ----- PRL RD QFE aff A R p D TFA LG V CNG C Q MMSN L K ----- E I I P GAEHW P RFVR N RSEQFEA R FSLVE V QESP S IF L 1178
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1137 s KTSV G DIHTV A IS HGEGR FVAS D EV LA Q L R A N G QI A TQ YVD ET G TPGMDLDV NPNGS LLA I E G I T SP DGRV FGK M G H S E 1216
Cdd:PRK05297 1179 - QGMA G SRLPI A VA HGEGR AEFP D AH LA A L E A K G LV A LR YVD NH G QVTETYPA NPNGS PNG I T G L T TA DGRV TIM M P H P E 1257
..
gi 499380727 1217 R S 1218
Cdd:PRK05297 1258 R V 1259
Name
Accession
Description
Interval
E-value
FGAM-synthase
TIGR01857 phosphoribosylformylglycinamidine synthase, clade II; This model represents a single-molecule ...
3-1242
0e+00
phosphoribosylformylglycinamidine synthase, clade II; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This model represents a second clade of these enzymes found in Clostridia, Bifidobacteria and Streptococcus species. This enzyme performs the fourth step in IMP biosynthesis (the precursor of all purines) from PRPP. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 130916 [Multi-domain]
Cd Length: 1239
Bit Score: 2286.31
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 3 F RV Y VEKK P GFDVE A Q Q L AG ELR TI LGL TG LK A LRIVN R YDV EGISQ ELF DQ TV P T V FSEP QV D N V AYD L PDF A G - AK V F 81
Cdd:TIGR01857 1 K RV F VEKK A GFDVE S Q S L VK ELR HN LGL SS LK D LRIVN V YDV FDLAE ELF AP TV K T I FSEP VT D H V LDE L SVQ A D l AK F F 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 82 A T EFLPGQFDQRADSA A ECI Q L I S QG E RP TV RS AKLY A L E GDL T D ADVDT IK H Y V INPV EA RE AS L E T KET L KTQVPV P G 161
Cdd:TIGR01857 81 A V EFLPGQFDQRADSA Q ECI L L L S ES E DV TV NT AKLY I L N GDL D D EELNK IK N Y Y INPV DS RE KD L T T GKA L EEFSES P K 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 162 K VET IA GF NEM DAE AGQ KF ID E R GLAM D L A DL E F C Q K YF SEES R E PT I TEIKV I DTYWSDHCRHTTF G TEL DE VT ID D -- 239
Cdd:TIGR01857 161 E VET LT GF ESY DAE DLA KF KA E Q GLAM S L E DL K F I Q D YF KSIG R N PT E TEIKV L DTYWSDHCRHTTF E TEL KH VT FS D sk 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 240 -- ATV K A A F E R YLAMR H ELGR DA KPV C LMDM G TI G AK W L K KNG V L TG L DE SEEINAC T V KVK VDV N G HD E D WL FL FKNET 317
Cdd:TIGR01857 241 fq KQL K K A Y E D YLAMR E ELGR SE KPV T LMDM A TI F AK Y L R KNG K L DD L EV SEEINAC S V EIE VDV D G VK E P WL LM FKNET 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 318 HNHPTEIEPFGGAATCIGG C IRDPLSGRSYVYQAMRVTGA A DPTVP V SETL E GKLPQRK LV TTAA A GYSSYGNQIGLATG 397
Cdd:TIGR01857 321 HNHPTEIEPFGGAATCIGG A IRDPLSGRSYVYQAMRVTGA G DPTVP I SETL K GKLPQRK IT TTAA H GYSSYGNQIGLATG 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 398 QV D EIYHPGYVAKRMEVGAVVAATP ADH V R RE T P A PGD K IILLGG R TGRDGIGGATGSSK A H N VESLEL D GAEVQKGNAP 477
Cdd:TIGR01857 401 QV S EIYHPGYVAKRMEVGAVVAATP KEN V V RE K P E PGD V IILLGG K TGRDGIGGATGSSK E H T VESLEL C GAEVQKGNAP 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 478 V ERK L QRLFR R G DAC RLIK R CNDFGAGGVSVA V GELADGL FV DLN T VPKKYEGL D GTELAISESQERMAV D V DA EDVD E F 557
Cdd:TIGR01857 481 E ERK I QRLFR N G NVT RLIK K CNDFGAGGVSVA I GELADGL EI DLN K VPKKYEGL N GTELAISESQERMAV V V SP EDVD A F 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 558 LAY AR EENLEATV I ATVTE D PR M VM T WNG DK IV N LSR E FL AS NG ASKHQTVH V EEQ ---- QSYETPWGEG TL A E RMN K LV 633
Cdd:TIGR01857 561 LAY CN EENLEATV V ATVTE K PR L VM N WNG KT IV D LSR R FL DT NG VRQVIDAK V VDK dvkl PEERQKTSAE TL E E DWL K VL 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 634 T D I NVAS N KGL S ERFDS TI GAGTVLMP F GGK R QLTP NM A M VAKLPV F - GET T TASA M AWGFNPYI MSKNQFT GA YLS V V E 712
Cdd:TIGR01857 641 S D L NVAS Q KGL Q ERFDS SV GAGTVLMP L GGK Y QLTP TE A S VAKLPV L g GET H TASA I AWGFNPYI AEWSPYH GA AYA V I E 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 713 SLAKLVAAG FEHE KA Y LSFQEYFEKL RDEP ERWGKP A AA V LGA LM AQ V DLG AG AIGGKDSMSG S FE D L D VPPTLISFAV A 792
Cdd:TIGR01857 721 SLAKLVAAG ADYK KA R LSFQEYFEKL DKDA ERWGKP F AA L LGA IK AQ I DLG LP AIGGKDSMSG T FE E L T VPPTLISFAV T 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 793 VG N MK R AT SPEFK D A DHR I VR I APRY L A DG l T P D K D A L L E V F SV IEEL TDF H DALAV S TPG YG AT AE A L F KMT L GNRIG V 872
Cdd:TIGR01857 801 TA N SR R VI SPEFK A A GEN I YL I PGQA L E DG - T I D F D L L K E N F AQ IEEL IAD H KVVSA S AVK YG GV AE S L A KMT F GNRIG A 879
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 873 T LN DSI a VD DLFT PA YGSFI V E LADD aklpav SNLVEIGE IG T TT SEY V F K AA GE T LDL DAVQE AWE SGI E S VFP Y rs K G 952
Cdd:TIGR01857 880 E LN NPE - LE DLFT AQ YGSFI F E SPEE ------ LSIANVEK IG Q TT ADF V L K VN GE K LDL EELES AWE GKL E E VFP S -- K F 950
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 953 EDK GA TVE TIDFHAP KK TVYVGSS V A KP H VVIPVFPG N N C EYDSA A AFE RA GA D V TTL I VN NL TPA A VA ES TQAL VDEI N 1032
Cdd:TIGR01857 951 EDK KE TVE VPAVASE KK VIKAKEK V E KP R VVIPVFPG T N S EYDSA K AFE KE GA E V NLV I FR NL NEE A LV ES VETM VDEI D 1030
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1033 KSQI V M I PGGFS G GDEPDGSAKFI T A FF R A P A V TE A VRDL L k N RDGL M LGICNGFQALVK L GL V PYG D I VPMTDAC PTLT 1112
Cdd:TIGR01857 1031 KSQI L M L PGGFS A GDEPDGSAKFI A A IL R N P K V RV A IDSF L - A RDGL I LGICNGFQALVK S GL L PYG N I EAANETS PTLT 1109
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1113 F N T I G RH Q S RL VRTR V AS DL SPWLS KT SVGDIH TVAI SHGEGRFVASDEVLA Q LR A NGQIATQYVD ET G T P G MD LDV NPN 1192
Cdd:TIGR01857 1110 Y N D I N RH V S KI VRTR I AS TN SPWLS GV SVGDIH AIPV SHGEGRFVASDEVLA E LR E NGQIATQYVD FN G K P S MD SKY NPN 1189
1210 1220 1230 1240 1250
....*....|....*....|....*....|....*....|....*....|
gi 499380727 1193 GS L LAIEGITSPDGR V FGKMGHSER S G N GL YV N V PGNK Y Q PI F EA GV E YF 1242
Cdd:TIGR01857 1190 GS S LAIEGITSPDGR I FGKMGHSER Y G D GL FK N I PGNK D Q HL F AS GV K YF 1239
PurL_repeat1
cd02203 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. ...
211-592
5.64e-134
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100034 [Multi-domain]
Cd Length: 313
Bit Score: 411.48
E-value: 5.64e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 211 E IKVIDTY WS D HCRH TT F GTE L DEV tiddatvkaaferylamrhelgrdakpvclmdmgtigakwlkkngvltgldesee 290
Cdd:cd02203 1 E LGMFAQM WS E HCRH KS F KSL L KMI ------------------------------------------------------- 25
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 291 inactvkvkvdvnghded W LFL FK N ETHNHP TE IEPFGGAAT CI GG C IRD P LS GRSYVYQAMRVTGAA D PTV P VS E t LE G 370
Cdd:cd02203 26 ------------------ W AVV FK V ETHNHP SA IEPFGGAAT GV GG I IRD I LS MGARPIALLDGLRFG D LDI P GY E - PK G 86
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 371 KL PQ R KLVTTAA AG Y S S YGN Q IG LA T GQVDEIYH P G Y VAKRMEVGAV V AAT P A DH VRR - ET P A PGD KII L L GGRTGRDGI 449
Cdd:cd02203 87 KL SP R RILDGVV AG I S D YGN C IG IP T VGGEVRFD P S Y YGNPLVNVGC V GIV P K DH IVK s KA P G PGD LVV L V GGRTGRDGI 166
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 450 GGAT G SSK AHNVE S L ELD GAE VQ K G NAPV E R KLQ RLFRRGDACR LI KRCN D F GAGG V S V AV G E L A ---- D G LFV DL NT VP 525
Cdd:cd02203 167 GGAT F SSK ELSEN S S ELD RPA VQ V G DPFM E K KLQ EAILEARETG LI VGIQ D L GAGG L S S AV S E M A akgg L G AEI DL DK VP 246
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499380727 526 KKYE G LDGT E LA ISESQERM AVD V DA ED VD EFLA YARE E N LEA T VI AT VT E D P R MVMTWN G DKIVN L 592
Cdd:cd02203 247 LREP G MSPW E IW ISESQERM LLV V PP ED LE EFLA ICKK E D LEA A VI GE VT D D G R LRLYYK G EVVAD L 313
GATase_5
pfam13507 CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not ...
979-1242
2.47e-109
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not found in pfam00310, pfam07685 and pfam13230.
Pssm-ID: 463904 [Multi-domain]
Cd Length: 260
Bit Score: 343.71
E-value: 2.47e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 979 KP H V V I PVF PG N N C EY DS AAAFERAG A D VTTLIVNN L TPAA V aestqalvd EINKS Q IVMI PGGFS G GD EP d GS A K FIT A 1058
Cdd:pfam13507 1 KP R V A I LRE PG T N G EY EM AAAFERAG F D AVDVHMSD L LSGR V --------- SLDDF Q GLAA PGGFS Y GD VL - GS G K GWA A 70
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1059 FFR - A P AVTE A VRDLLKNR D GLM LGICNG F Q A L V KLGL V P Y G DIVPMTD a C PTLT F N TI GR HQ SR L V RTRV a S DL SP WLS 1137
Cdd:pfam13507 71 SIL f N P KLRD A FEAFFNRP D TFS LGICNG C Q L L S KLGL I P G G EGDLAER - W PTLT R N DS GR FE SR W V NVKI - S EK SP SVF 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1138 k TSVG D IHTVAIS HGEGRFV A - S D EVLA Q L R ANGQ I A TQ YVD ET G T P GMDLDV NPNGS L L A I E GI T SPDGRV F G K M G H S E 1216
Cdd:pfam13507 149 - LRGM D GSGLPVA HGEGRFV F r S E EVLA R L E ANGQ V A LR YVD NA G N P TEEYPF NPNGS P L G I A GI C SPDGRV L G L M P H P E 227
250 260 270
....*....|....*....|....*....|...
gi 499380727 1217 R SGNGLYVN - V P G ------ NKYQPI F EAGVEYF 1242
Cdd:pfam13507 228 R VFRPWQWP h W P P geweev SPWLRL F RNARKWV 260
PurL2
COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain ...
980-1243
3.45e-109
Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439817 [Multi-domain]
Cd Length: 236
Bit Score: 342.42
E-value: 3.45e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 980 P H V V I P VFPG N NC EY D S AAAFERAGA DVTTLIVNN L tpaavaestqal VDEINKSQIVMI PGGFS G GD EPDGS A KFI taf 1059
Cdd:COG0047 1 P K V A I L VFPG S NC DR D M AAAFERAGA EAEDVWHSD L ------------ RTDLDDFDGLVL PGGFS Y GD YLRAG A IAA --- 65
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1060 f RA P a VTE AVR DLL k N R D GL M LGICNGFQ A L VK LGL V P y G D ivpmtda C P T LT F N TIG R HQS R L V RT RV ASDL SP WL S KT 1139
Cdd:COG0047 66 - FS P - IMD AVR EFA - R R G GL V LGICNGFQ I L TE LGL L P - G I ------- W P A LT R N RSL R FIC R W V YL RV ENND SP FT S GM 134
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1140 SV G DIHTVA I S HGEGR F VA SD E V LA Q L R ANGQ I A TQ YVD ET G TPGM dl DV NPNGSL LA I E GIT SP DG R V F G K M G H S ER SG 1219
Cdd:COG0047 135 EA G EVIPIP I A HGEGR Y VA DE E T LA E L E ANGQ V A FR YVD AD G NVTY -- PA NPNGSL NN I A GIT NE DG N V L G M M P H P ER AV 212
250 260
....*....|....*....|....
gi 499380727 1220 NG L YVNVPGNKYQP IF EAG V E YF A 1243
Cdd:COG0047 213 EP L LGPGESTDGLR IF RSA V K YF G 236
PurL1
COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and ...
171-946
1.66e-90
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439816 [Multi-domain]
Cd Length: 747
Bit Score: 308.90
E-value: 1.66e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 171 E MDA EA GQKFID E R GLA md L A D L E F c QKYFSEES R E PT IT E IKVIDTY WS D HC RHTTF gteldevtiddatv K A AFERY l 250
Cdd:COG0046 7 E GGR EA LEEANR E L GLA -- L S D D E Y - DYIVEILG R N PT DV E LGMFSQM WS E HC SYKSS -------------- N A LLKSL - 68
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 251 amrhelgrdakpvclmdmgtigak WLKKNG VL T G LDE seei NA CT V KV kvdvngh DEDWLFL FK N E T HNHP TE IEP FG GA 330
Cdd:COG0046 69 ------------------------ PTEGPR VL S G PGD ---- NA GV V DI ------- GDGLAVV FK V E S HNHP SA IEP YQ GA 113
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 331 AT CI GG C IRD PLS grsyvyqa M rvt GA ----------- ADPTV P VSETLE gklpqrk LVTTAA AG YSS YGN QI G LA T -- G 397
Cdd:COG0046 114 AT GV GG I IRD IFG -------- M --- GA rpiagldslrf GNLDQ P PASPRY ------- ILIGVV AG IAD YGN CF G VP T vg G 175
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 398 qvd E IY - HPG Y VAKR - MEV G A V v AATP ADH VRR - ET P AP G D K IILL GG R TGRDGIGGAT GS S KAHNVE S l ELD GAE VQ K G 474
Cdd:COG0046 176 --- E VR f DES Y EGNP l VNA G G V - GIIR ADH IFK a KA P GV G N K VVYV GG P TGRDGIGGAT FA S EELGED S - ELD RPA VQ V G 250
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 475 NAPV E RK L Q rlfrrg D A CR ------ LI KRCN D F GAGG V S V A VG E L A D ---- G LFV DL NT VP KKYE G LDGT E LAI SESQER 544
Cdd:COG0046 251 DPFM E KR L I ------ E A IL elgdtg LI VGIQ D M GAGG L S S A SS E M A A kggl G AEI DL DK VP LREP G MSPY E IWL SESQER 324
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 545 M AVD V DA E DVD EF L A YAREEN L E A T VI AT VT E D P R M V M T WN G DKIVN L SRE FLA SNGASK H QTVHVEEQQSYETPWGEGT 624
Cdd:COG0046 325 M LLV V KP E KLE EF E A IFERWR L P A A VI GE VT D D G R L V V T DH G ETVAD L PLD FLA GGAPKY H RPAKRPAYLEPLDLPEPID 404
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 625 L A E RMNK L VTDI NVAS NKG L SERF D STI G AG TV LM P fggkrql TPNM A M V AKL pvf GE T TTAS AM AW G F NP YIMSKNQFT 704
Cdd:COG0046 405 L E E ALLR L LSSP NVAS KEW L YRQY D REV G GN TV RD P ------- GVAD A A V VRV --- DG T YKGL AM ST G E NP RYALLDPYA 474
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 705 GA YLS V V E SLAK L V A A G F E HEKAYLSFQ ey F --- EK lrde PE RWGKPAA AV L G al M A QV -- D LG AGAIG G KD S MSGSFE D 779
Cdd:COG0046 475 GA RMA V A E AARN L A A V G A E PLAITDCLN -- W gnp EK ---- PE EMAQLVE AV K G -- L A DA cr A LG IPVPS G NV S LYNETK D 546
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 780 LD V -- PPT LISF AV A - V GNMKRATS P EF K DADHRIVR I --- APR ----- Y LA ----- D G LT PD K D ALL E -- V F SVIE EL T 841
Cdd:COG0046 547 GK V ai PPT PVIG AV G l V DDVRKTVT P DL K KEGDLLYL I get KNE lggse Y AQ vlgql G G EP PD V D LEA E ka L F EAVQ EL I 626
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 842 D ------ F HD ala VS TP G YGA tae AL FK M TLGNRI G VTLN ----- D SIAVDD LF TPAY G SFI V EL A DD a KLP AV SN L --- 907
Cdd:COG0046 627 R eglila A HD --- VS DG G LAV --- AL AE M AFAGGL G ADID ldalg D LRPDAA LF SESQ G RAV V QV A PE - DAE AV EA L lae 699
810 820 830 840
....*....|....*....|....*....|....*....|....*.
gi 499380727 908 -- VEIGE IGT T T SEY -- V FKAA GETL --- D L DAVQE AWE SGIESVF 946
Cdd:COG0046 700 ag LPAHV IGT V T GDD rl V IRRG GETL lsl S L AELRD AWE ETLPRLR 745
GATase1_FGAR_AT
cd01740 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ...
982-1239
1.47e-83
Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT). FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway. FGAR-AT is a glutamine amidotransferase. Glutamine amidotransferase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. FGAR-AT belongs to the triad family of amidotransferases having a conserved Cys-His-Glu catalytic triad in the glutaminase active site
Pssm-ID: 153211 [Multi-domain]
Cd Length: 238
Bit Score: 272.57
E-value: 1.47e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 982 V VIPV FPG N NC EY D S A A AFE R AG ADVTTLIV N N L T paavaestq A LVDEINKSQI V MI PGGFS G GD EPDGS A KFITAFFR 1061
Cdd:cd01740 1 V AVLR FPG S NC DR D M A Y AFE L AG FEAEDVWH N D L L --------- A GRKDLDDYDG V VL PGGFS Y GD YLRAG A IAAASPLL 71
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1062 APA V T E AVR dllkn R D GL M LGICNGFQ A LV K LGL V P YGD I VP mtdac PT L T F NT ig R H Q S R L V RT RV ASDL SP WLSKTSV 1141
Cdd:cd01740 72 MEE V K E FAE ----- R G GL V LGICNGFQ I LV E LGL L P GAL I RN ----- KG L K F IC -- R W Q N R F V TL RV ENND SP FTKGYME 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1142 G DIHTVAIS HGEGRF V A S DE V LA Q L RA NGQIA t QYVD ET G TPGMDLDV NPNGSL LA I E GI TSP DGRV F G K M G H S ER SGNG 1221
Cdd:cd01740 140 G EVLRIPVA HGEGRF Y A D DE T LA E L EE NGQIA - QYVD DD G NVTERYPA NPNGSL DG I A GI CNE DGRV L G M M P H P ER AVEP 218
250 260
....*....|....*....|
gi 499380727 1222 LY -- VNVP G NKYQPI F EAG V 1239
Cdd:cd01740 219 WQ we RLLG G SDGLKL F RNA V 238
FGAM_synt
TIGR01735 phosphoribosylformylglycinamidine synthase, single chain form; This model represents a ...
118-1217
9.06e-80
phosphoribosylformylglycinamidine synthase, single chain form; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is found mostly in eukaryotes and Proteobacteria. In Bacillus subtilis PurL (FGAM synthase II) and PurQ (FGAM synthase I), homologous to different parts of this model, perform the equivalent function; the unrelated small protein PurS is also required and may be a third subunit. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 188163 [Multi-domain]
Cd Length: 1310
Bit Score: 287.84
E-value: 9.06e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 118 Y A L E G -- D L TDADVDTIKHYVINPVE ar E AS L ETKETLKT -- Q VP V P GKVE TI AGFNE m DAE A GQ K FID E R GLA M D LADL 193
Cdd:TIGR01735 111 Y Y L S G ah P L SEEQEAQAAALLHDRMT -- E SV L PHEIEAFE lf S VP E P LNLT TI DVLGG - GRL A LE K ANQ E L GLA L D EDEI 187
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 194 EFCQ K Y F S E ES R E P TIT E IKVIDTYW S D HCRH TT F GTEL dev T ID DA tvkaaferyl AMRHE L grdakpvclmd MGT I GA 273
Cdd:TIGR01735 188 DYLT K R F Q E LQ R N P SDV E LMMFAQAN S E HCRH KI F NADW --- I ID GK ---------- KQDKS L ----------- FQM I KS 243
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 274 KW - LKKNGVLTGL - D E S EE I NACT V K ------- VKVDVNG H D ED WL - F L F K N ETHNHPT E I E PF G GA A T CI GG C IRD --- 340
Cdd:TIGR01735 244 TH e ANPENTVSAY k D N S SV I EGHK V G rlrpdpp TRPEYRQ H Q ED LV h I L M K V ETHNHPT A I A PF P GA S T GA GG E IRD ega 323
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 341 ------ P LS G RS - YVYQAMRVT G AAD P T vpvs E TLEG K l P Q R ----- KLVTT A AA G YSSYG N QI G --------------- 393
Cdd:TIGR01735 324 tgrgak P KA G LT g FCVSNLNIP G LEQ P W ---- E DPFQ K - P E R iaspl DIMIE A PL G AAAFN N EF G rpnllgyfrtfelka 398
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 394 - L AT GQV DE i YH pgyva K RMEVGAVVAATP A D H VRRETPA PG DKI I L LGG RTGRD G I GG ATG SS KAHNVESLE LD G A E VQ 472
Cdd:TIGR01735 399 s L PG GQV RG - YH ----- K PIMLAGGIGSID A E H IQKGEIE PG ALL I V LGG PAMLI G L GG GAA SS MVSGTNTAD LD F A S VQ 472
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 473 K GN APV ER KL Q RLFR R ---- G DA c RL I KRCN D F GAGG V S V A VG EL AD ---- G LFV DL NT VP KKYE GL DGT E LAIS ESQER 544
Cdd:TIGR01735 473 R GN PEM ER RC Q EVID R cwql G EK - NP I ISIH D V GAGG L S N A LP EL IH dggr G AVI DL RA VP LDDP GL SPL E IWCN ESQER 551
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 545 MAVD V D AE DVDE F L A YARE E NLEAT V IA T V T E D P R MVM -------- TWN GD ------- KI V N L SR E F L ASNGASKHQT V H 609
Cdd:TIGR01735 552 YVLL V R AE NLEI F T A ICER E RCPFA V VG T A T G D G R LTL vddtpvrr NGQ GD apshfpn NP V D L PL E V L LGKMPKMTRF V Q 631
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 610 -- VEEQ Q SYET P W G E g T L A E RMNKLVTDIN VAS NKG L SERF D STI G AGTVLMPFG G KR Q LT pn M A M VA KLPVFGE T T T AS 687
Cdd:TIGR01735 632 rk APML Q PLDI P P G L - D L H E ALERVLRLPA VAS KRF L ITIG D RSV G GLVARDQMV G PW Q TP -- L A D VA VTAASFD T Y T GE 708
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 688 AMA W G FN P YIMSKNQFTG A Y L S V V E SLAK L V AA GFEHEK - AY LS FQ - EYFEKLRD E PERWGKPAA AV L g A L MAQVDL gag 765
Cdd:TIGR01735 709 AMA I G ER P PKALLDPKAS A R L A V G E AITN L A AA LVGDLS d VK LS AN w MAAAGHPG E DAALYDAVK AV S - E L CPALGI --- 784
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 766 AI - G GKDS M S -------- G SFEDLDV P PT L - IS FAVA V GNMKRATS P EF K DADHRIV ----------- R IAPRY LA D --- 821
Cdd:TIGR01735 785 AI p V GKDS L S mktrwqdn G ETKSVTA P GS L v IS AFAP V PDVRKTVT P DL K HDKGDSH lllvdlgpgkn R LGGSA LA Q vfg 864
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 822 --- G LT PD K D A --- L LEV F S V IEE L TDFHDA LA VSTPGY G ATAEA L FK M TLGNRI G VTLN - D SIAVDD --- LF TPAY G S f 891
Cdd:TIGR01735 865 qlg G DC PD L D D per L KAF F A V MQG L VAEGLL LA YHDRSD G GLVTT L LE M AFAGHC G LDVD l D ALGDSL fav LF NEEL G A - 943
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 892 IVEL A DDA k L P AV SN L VE ------- I GE IGT T T SEYVF -- KAA G E TL --- DLDAVQEA WE SGIESVFPY R SKG E DKGATV 959
Cdd:TIGR01735 944 VIQV A KPD - L A AV LE L LR aagltal I LG IGT P T GHPMI ri SVN G A TL lse KRSELRDI WE ETSFQLQRL R DNP E CAEEEF 1022
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 960 E TI - D FHA P ---- KK T VY V GSSV A K P HVVIP V F P -------- G N N CEYDS AAAF E RAG ADVTTLIVNN L tpaavaestqa 1026
Cdd:TIGR01735 1023 E GL r D RDG P glkl PL T FD V NEDI A A P FINKG V K P kvailreq G V N GDREM AAAF D RAG FEAWDVHMSD L ----------- 1091
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1027 L VDEINKSQIVMIP -- GGFS G GD EPD --- G S AK F I T af F R a P AVTEAVRDLL K NR D GLM LG I CNG F Q A L VK L glvpy GDI 1101
Cdd:TIGR01735 1092 L AGRVHLDEFRGLA ac GGFS Y GD VLG agk G W AK S I L -- F N - P RLRDQFQAFF K RP D TFS LG V CNG C Q M L SN L ----- LEW 1163
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1102 V P M T DAC P TLTF N TIG R HQS R LVRT RV ASDL S PW L SKTS v G DIHT VA IS HGEG R - FVA S D E VL AQ LR A N G QI A TQ Y V D ET 1180
Cdd:TIGR01735 1164 I P G T ENW P HFVR N NSE R FEA R VASV RV GESP S IM L RGMA - G SRLP VA VA HGEG Y a AFS S P E LQ AQ AD A S G LA A LR Y I D DD 1242
1210 1220 1230
....*....|....*....|....*....|....*..
gi 499380727 1181 G T P GMDLDV NPNGS LLA I E GITS P DGRV FGK M G H S ER 1217
Cdd:TIGR01735 1243 G N P TEAYPL NPNGS PGG I A GITS C DGRV TIM M P H P ER 1279
FGAM_synth_II
TIGR01736 phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a ...
205-943
1.23e-71
phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a single, long polypeptide in most Proteobacteria and eukarotes. Three proteins are required in Bacillus subtilis and many other species. This is the longest of the three and is designated PurL, phosphoribosylformylglycinamidine synthase II, or FGAM synthase II. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273781 [Multi-domain]
Cd Length: 715
Bit Score: 254.53
E-value: 1.23e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 205 REP TI TE IKVIDTY WS D HC RH ttfgteldevtiddatvkaaferylamrhelg RDA K P vc L MDMGTIGAKW lkkng V LT G 284
Cdd:TIGR01736 15 REP ND TE LAMFSAM WS E HC SY -------------------------------- KSS K K -- L LKQFPTKGPN ----- V IQ G 55
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 285 LD E seei N A CT V KV kvdvngh DEDWLFL FK N E T HNHP TE IEP FG GAAT CI GG CI RD P LS GRSYVYQAMRVTGAADPTV P v 364
Cdd:TIGR01736 56 PG E ---- D A GV V DI ------- GDGYAVV FK M E S HNHP SA IEP YN GAAT GV GG IL RD I LS MGARPIALLDSLRFGPLDD P - 123
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 365 setlegkl PQ R K L VTTAA AG Y S S YGN Q IG LA T -- G Q V D ei YHPG Y VAKRM - E V GA V VAATPA D H V RRETPA PG D K II L L G 441
Cdd:TIGR01736 124 -------- KN R Y L FEGVV AG I S D YGN R IG VP T vg G E V E -- FDES Y NGNPL v N V MC V GLVRKD D I V TGKAKG PG N K LV L V G 193
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 442 G R TGRDGIGGAT GS S KAHNV E SL E L D GAE VQ K G NAPV E RK L QRLFRRGDACR L I K RCN D F GA G G VSV A VG E L A D ---- G L 517
Cdd:TIGR01736 194 G K TGRDGIGGAT FA S EELSE E AE E E D RPA VQ V G DPFT E KL L IEATLEAVDTG L V K GIK D L GA A G LTS A SS E M A A kggl G A 273
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 518 FVD L NT VP KKYE G LDGT E LAI SESQERM AVD V DA EDV D E F L AYAREEN L E A T VI AT VT EDP R MVMTWN G DKIVN L SR E F L 597
Cdd:TIGR01736 274 EIY L DK VP LREP G MTPY E IML SESQERM LLV V AP EDV E E V L EIFEKYE L P A S VI GE VT DEG R IRLYYK G EVVAD L PI E L L 353
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 598 A -------- S NGASKHQTVHVE E QQS yetpwgeg T L AERMN K LVTDI N V AS NKGLSERF D STIGAG TV LM P FGG krqltp 669
Cdd:TIGR01736 354 A dapeyerp S EPPKYPEEEKEP E PPA -------- D L EDAFL K VLSSP N I AS KEWVYRQY D HEVQTR TV VK P GED ------ 419
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 670 nm A M V AKLP vf GETTTAS A MAWGF NP YIMSKNQFT GA YLS V V E SLAK L V A A G F E HEK A Y -- L S F QEY f E K lrde PE RWGK 747
Cdd:TIGR01736 420 -- A A V LRIK -- ETGKLGL A LTADC NP RYVYLDPYA GA AGA V A E AYRN L A A V G A E PLA A V dc L N F GNP - E R ---- PE VYWQ 490
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 748 PAA AV L G ALM A QVD LG AGAI GG KD S MSGSFEDLDVP PT LISFA V A - V GNMKRATSPE FK DADHR I VR I -------- APR Y 818
Cdd:TIGR01736 491 FVE AV K G LGD A CRA LG TPVV GG NV S LYNETNGVPIA PT PTIGM V G l V EDVEKLLTSN FK KEGDA I YL I getkdelg GSE Y 570
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 819 L A ------ D G LT P -- D KDALL E VFSVIE E LTDFHDAL A VSTPGY G AT A E AL FK M TLGNR IG VTL ----- NDSIAVDD LF T 885
Cdd:TIGR01736 571 L R vihgiv S G QV P av D LEEEK E LADAVR E AIRAGLVS A AHDVSR G GL A V AL AE M AAASG IG AEV didei ASARPDEL LF S 650
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499380727 886 PAY G SF IV ELADDAKLP AV - S NL V EIGE IG T T TSEYV - F K AAGE T LDLDA -- VQE AWE SGIE 943
Cdd:TIGR01736 651 ESN G RA IV AVPEEKAEE AV k S KG V PAKV IG K T GGDRL t I K TGDD T ISVSV ke LRD AWE EALP 712
PRK05297
PRK05297 phosphoribosylformylglycinamidine synthase; Provisional
118-1218
3.23e-61
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 235394 [Multi-domain]
Cd Length: 1290
Bit Score: 230.07
E-value: 3.23e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 118 Y AL E GD L TDADVDTIKHYVINP - V E ARE A S L ETK E T L KTQVP v P GKVETI --- A G FNEMDAE A GQKF ider GLA MDLADL 193
Cdd:PRK05297 109 Y YV E AA L SAEQRAALAALLHDR m T E SVF A D L DDA E A L FSHHE - P KPLTSV dvl G G GRAALEA A NVEL ---- GLA LAEDEI 183
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 194 EFCQKY F SEES R E PT IT E IKVIDTYW S D HCRH TT F GTEL dev TID DA tvkaaferylamrhelgrd AK P VC L MD M ----- 268
Cdd:PRK05297 184 DYLVEA F TKLG R N PT DV E LMMFAQAN S E HCRH KI F NADW --- TID GE ------------------- EQ P KS L FK M iknth 241
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 269 ----- G TIG A kw L K K N - G V LT G ldeseein ACTVKVKV D VNG ----- H D E DWLF L F K N ETHNHPT E I E PF G GAAT CI GG C 337
Cdd:PRK05297 242 etnpd G VLS A -- Y K D N a A V ME G -------- SKVGRFFP D PDT grygy H Q E PAHI L M K V ETHNHPT A I S PF P GAAT GS GG E 311
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 338 IRD --------- P LS G R ----- S Y vyqa M R VT G AAD P T vpvs E TLE GK l P Q R ----- KLVTTAAA G YSSYG N QI G ----- 393
Cdd:PRK05297 312 IRD egatgrgsk P KA G L tgfsv S N ---- L R IP G FEQ P W ---- E EDY GK - P E R iasal DIMIEGPL G GAAFN N EF G rpnll 382
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 394 -------- LATGQVD E IY hp GY VAKR M EV G AVVAAT p ADHV RRETPAP G D K I I L LGG RTG R D G I GG ATG SS K A HNVE S LE 465
Cdd:PRK05297 383 gyfrtfeq KVNSHNE E VR -- GY HKPI M LA G GIGNIR - ADHV QKGEIPV G A K L I V LGG PAM R I G L GG GAA SS M A SGQS S ED 459
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 466 LD G A E VQ K GN APV ER KL Q RLFR R ---- GD A c RL I KRCN D F GAGG V S V A VG EL AD ----- G L F v DL NTV P KKYE G LDGT E L 536
Cdd:PRK05297 460 LD F A S VQ R GN PEM ER RC Q EVID R cwql GD D - NP I LSIH D V GAGG L S N A FP EL VN dggrg G R F - DL RKI P NDEP G MSPL E I 537
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 537 AIS ESQER MAVDVDA ED VDE F L A YARE E NLEAT V IATV TE DPRMVM -- TWNGD K I V N L SREF L ASNGASK H QT V HVEEQQ 614
Cdd:PRK05297 538 WCN ESQER YVLAIAP ED LEL F E A ICER E RCPFA V VGEA TE ERHLTL ed SHFDN K P V D L PLDV L LGKPPKM H RD V KTVKAK 617
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 615 SYETPWGEGT LAE --- R MNK L V T din VAS nkgls ER F DS TIG AGT V lmpf G G krqltpnma M VA K -------- L PV ---- 679
Cdd:PRK05297 618 GPALDYSGID LAE ave R VLR L P T --- VAS ----- KS F LI TIG DRS V ---- T G --------- L VA R dqmvgpwq V PV adca 676
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 680 --------- F GE tttas AMA W G FNPYIMSKNQFTG A YLS V V E S L AKLV AA ------------------ G FEH E K A Y L sfq 732
Cdd:PRK05297 677 vtaasydgy A GE ----- AMA M G ERTPVALLDAAAS A RMA V G E A L TNIA AA pigdlkriklsanwmaaa G HPG E D A R L --- 748
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 733 ey FEKLR deperwgkpaa AV LGA L MAQVDL gag A I - G GKDS M S ------ GSF ED LD V -- P PT LI -- S FA v A V GNMKRATS 801
Cdd:PRK05297 749 -- YDAVK ----------- AV GME L CPALGI --- T I p V GKDS L S mktkwq EGG ED KE V ts P LS LI is A FA - P V EDVRKTLT 811
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 802 P EFK - D A D HRIVR I -------------- A PR Y -- L A D G l T PD - K DA -- L LEV F SV I EE L TD ------ F HD ala V S TP G YG 855
Cdd:PRK05297 812 P QLR t D K D TALLL I dlgrgknrlggsal A QV Y nq L G D K - A PD v D DA ed L KGF F NA I QA L VA egllla Y HD --- R S DG G LL 887
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 856 A T aea L FK M TLGNRI G VTLN - D SIAV D D --- LF TPAY G sf I V ELADD A KLP AV SN - L V E I G ------ E IG TTTS -- EY V F 922
Cdd:PRK05297 888 T T --- L AE M AFAGHC G LDID l D ALGD D A laa LF NEEL G -- A V IQVRA A DRD AV EA i L A E H G lsdcvh V IG KPNA gd RI V I 962
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 923 KAA G E T L --- DLDAVQEA W E ---------- SGI E SV --- F PYRSKGE D K G AT V E - T I D FHAPKKTVYVGSS v A K P H V V I P 985
Cdd:PRK05297 963 TRN G K T V fse SRTELRRW W S etsyqmqrlr DNP E CA dqe F DAILDQA D P G LN V K l T F D PNEDIAAPFIATG - A R P K V A I L 1041
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 986 VFP G N N CEYDS AAAF E RAG A D VTTLIVNN L tpaavaestqa L VDEINKSQIVMIP -- GGFS G GD EPD --- G S AK F I T af F 1060
Cdd:PRK05297 1042 REQ G V N SHVEM AAAF D RAG F D AIDVHMSD L ----------- L AGRVTLEDFKGLV ac GGFS Y GD VLG age G W AK S I L -- F 1108
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1061 R apavt EAV RD LLK --- N R - D GLM LG I CNG F Q ALVK L G lvpyg D I V P MTDAC P TLTF N TIGRHQS R LVRTR V ASDL S PW L 1136
Cdd:PRK05297 1109 N ----- PRL RD QFE aff A R p D TFA LG V CNG C Q MMSN L K ----- E I I P GAEHW P RFVR N RSEQFEA R FSLVE V QESP S IF L 1178
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1137 s KTSV G DIHTV A IS HGEGR FVAS D EV LA Q L R A N G QI A TQ YVD ET G TPGMDLDV NPNGS LLA I E G I T SP DGRV FGK M G H S E 1216
Cdd:PRK05297 1179 - QGMA G SRLPI A VA HGEGR AEFP D AH LA A L E A K G LV A LR YVD NH G QVTETYPA NPNGS PNG I T G L T TA DGRV TIM M P H P E 1257
..
gi 499380727 1217 R S 1218
Cdd:PRK05297 1258 R V 1259
PurL_repeat2
cd02204 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. ...
672-916
7.67e-60
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100035 [Multi-domain]
Cd Length: 264
Bit Score: 206.23
E-value: 7.67e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 672 A M V AKL P vf GET TTAS AM AW G F NP YIMSKNQFT GA Y L S V V E SLAK LVA A G FEH e K A YLSFQEYFEKLRD E p ERW G KPAA A 751
Cdd:cd02204 2 A A V LRI P -- GET DKGL AM ST G E NP RYSLLDPYA GA A L A V A E AVRN LVA V G ADP - L A ITDCLNFGNPEKP E - GEM G QLVE A 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 752 VLG ALM A QVD LG AGA IGGKDS MSGSF E DLDV PPTL ISF AV A - V GNMKRATSPE FK DADHRIVR I APRYLAD G L ------- 823
Cdd:cd02204 78 VLG LGD A CRA LG TPV IGGKDS LYNET E GVAI PPTL VIG AV G v V DDVRKIVTLD FK KEGDLLYL I GETKDEL G G seyalay 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 824 --------- TP D KDALLEV F SVIE EL TDFHDA L AVSTPGY G AT A E AL FK M TLGNRI G VTLN --- D SIAVDD LF TPAY G SF 891
Cdd:cd02204 158 hglgggapp LV D LEREKAL F DAVQ EL IKEGLV L SAHDVSD G GL A V AL AE M AFAGGL G AEVD lsk D DAEDEL LF SESL G RV 237
250 260
....*....|....*....|....*..
gi 499380727 892 I VE LADD -- AKLP A VSNL V EIGE IGT T 916
Cdd:cd02204 238 L VE VKPE ne EVFE A EEAG V PATV IGT V 264
PRK01213
PRK01213 phosphoribosylformylglycinamidine synthase subunit PurL;
205-946
2.28e-58
phosphoribosylformylglycinamidine synthase subunit PurL;
Pssm-ID: 234921 [Multi-domain]
Cd Length: 724
Bit Score: 215.35
E-value: 2.28e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 205 REP TI TE IKVIDTY WS D HC R httfgteldevtiddatvkaafer Y lamrhelg RDA KP vclmdmgtigak W L K K ----- N 279
Cdd:PRK01213 27 REP NF TE LGMFSVM WS E HC S ------------------------ Y -------- KSS KP ------------ L L R K fptkg P 62
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 280 G VL T G LD E seei NA CT V KV kvdvngh DEDWLFL FK N E T HNHP TEI EP FG GAAT CI GG CI RD PL S grsyvyqa M rvt GA -- 357
Cdd:PRK01213 63 R VL Q G PG E ---- NA GV V DI ------- GDGQAVV FK I E S HNHP SAV EP YQ GAAT GV GG IL RD IF S -------- M --- GA rp 120
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 358 --------- ADPTV P VS etlegklpq R K L VTTAA AG YSS YGN Q IG LA T -- G Q V D ei YHPG Y V ------ A kr M E VG A V vaa 420
Cdd:PRK01213 121 ialldslrf GELDH P KT --------- R Y L LEGVV AG IGG YGN C IG VP T vg G E V Y -- FDES Y N gnplvn A -- M C VG L V --- 184
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 421 t PA D HVRR - ETPAP G DKIILL G GR TGRDGIGGA TGS S K ahnvesl EL DGAE ------ VQ K G NAPV E RK L ---- QR L FRR G 489
Cdd:PRK01213 185 - RH D DIVL a KASGV G NPVVYV G AK TGRDGIGGA SFA S A ------- EL SEES eekrpa VQ V G DPFM E KL L ieac LE L IKT G 256
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 490 dacr L IKRCN D F GA G G VSVAVG E L A D ---- G LFV DL NT VP KKY EG LDGT E LAI SESQERM AVD V DAEDVD E F LA YAREEN 565
Cdd:PRK01213 257 ---- L VVGIQ D M GA A G LTCSSS E M A A kggl G IEL DL DK VP LRE EG MTPY E IML SESQERM LLV V KPGKEE E V LA IFEKWD 332
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 566 L E A T VI AT VT E D P R MVMTWN G DKIVNLSR E F LA SNGASKHQTVHVEEQQSYETPWG E g T L A E RMN KL VTDI N V AS NKGLS 645
Cdd:PRK01213 333 L D A A VI GE VT D D G R LRVYHH G EVVADVPA E A LA DEAPVYDRPYKEPAYLDELQADP E - D L K E ALL KL LSSP N I AS KEWVY 411
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 646 E RF D STIGAG TV LM P F G G krqltpnm A M V AKLP vfg ETTTAS A MAWGF NP --- Y I msk NQFT GA Y L S V V E SLAK L V A A G F 722
Cdd:PRK01213 412 E QY D HEVQTN TV VK P G G D -------- A A V LRIR --- GGGKGL A LTTDC NP ryv Y L --- DPYE GA K L A V A E AARN L A A V G A 477
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 723 EH ------------ EK aylsfqeyfeklrde PE RWGKPAA AV L G - A LMAQV d LG AGAI GG KD S MSGSFEDLDVP PT - L I s 788
Cdd:PRK01213 478 TP laitdclnfgnp EK --------------- PE VMWQFVE AV R G l A DACRA - LG TPVV GG NV S LYNETGGTAIY PT p V I - 540
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 789 fa VA VG --- NMKRA T SPE FK DADHR I VRI - APR ------- YL A ------ D G LT P DK D ALL E ------ V FSV I E E -- L T DF 843
Cdd:PRK01213 541 -- GM VG lid DVSKR T TSG FK KEGDL I YLL g ETK delggse YL K vihghv G G RP P KV D LEA E krlqel V REA I R E gl V T SA 618
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 844 HD ala VS T pgy G AT A E AL FK M TLGNRI G VTLN --- DSIAVDD LF TPAY G SFI V ELADDAKLP ---- A VSNL V EIGE IG TT 916
Cdd:PRK01213 619 HD --- VS E --- G GL A V AL AE M AIAGGL G AEVD lsd GLRPDAL LF SESQ G RYV V SVPPENEEA feal A EAAG V PATR IG VV 692
810 820 830
....*....|....*....|....*....|
gi 499380727 917 TSEYVFKAAGE T LD L DAVQ EAWE SGIESVF 946
Cdd:PRK01213 693 GGDALKVKGND T ES L EELR EAWE GALPRLL 722
PLN03206
PLN03206 phosphoribosylformylglycinamidine synthase; Provisional
159-1217
4.77e-50
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 178745 [Multi-domain]
Cd Length: 1307
Bit Score: 194.60
E-value: 4.77e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 159 VP GK V E T IAGFN E MD A e A GQKFID E R GLA M D LA DL EFCQKY F SEE - S R E PT IT E IKV I DTYW S D H C RH TT F GTE L dev T I 237
Cdd:PLN03206 150 VP EP V Y T VPVME E GR A - A LEEINK E M GLA F D EQ DL DYYTRL F RDD i K R D PT NV E LFD I AQSN S E H S RH WF F SGK L --- V I 225
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 238 D datvkaaferylamrhel G R d AK P VC L MD M GTIGA K WLKK N G V LTGL D E S EE I NACT V KVKVD V NG -------- H D E D W 309
Cdd:PLN03206 226 D ------------------ G Q - PM P KT L FQ M VKDTL K ANPN N S V IGFK D N S SA I RGFV V QPLRP V SP gspsplap V D R D L 286
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 310 LF L FKN ETHN H P TEIE P FG GA A T CI GG C IRD P - LS GR - S Y V YQA -------- M R VT G AAD P TVPV S ETLEGK L -- P QRK L 377
Cdd:PLN03206 287 DI L LTA ETHN F P CAVA P YP GA E T GA GG R IRD T h AT GR g S F V VAG tagycvgn L R IE G SYA P WEDS S FVYPSN L as P LQI L 366
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 378 VT t A AA G Y S S YGN QI G -------------- L AT G QVD E IYH P gyvakr MEVGAVVAATPAD H VRRET P AP G DKIILL GG R 443
Cdd:PLN03206 367 ID - A SN G A S D YGN KF G epliqgytrtfgmr L PN G ERR E WLK P ------ IMFSGGIGQIDHT H LTKGE P DI G MLVVKI GG P 439
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 444 TG R D G I GG ATG SS KAHNVESL ELD GAE VQ K G N A PVER KL Q R LF R rgd AC ------ RL I KRCN D F GAGG VSVA V G E L -- AD 515
Cdd:PLN03206 440 AY R I G M GG GAA SS MVSGQNDA ELD FNA VQ R G D A EMSQ KL Y R VV R --- AC vemged NP I VSIH D Q GAGG NCNV V K E I iy PK 516
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 516 G LFV D LNT V PKKYEG L DGT E LAIS E S QE RM A VDVDA E DV D EFLAYARE E NLEAT VI A T VTEDP R M V M --------- TW NG 586
Cdd:PLN03206 517 G AEI D IRA V VVGDHT L SVL E IWGA E Y QE QD A LLIKP E SR D LLQSICDR E RCSMA VI G T IDGSG R V V L vdsaapekc EA NG 596
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 587 DK ---- I V N L SR E FLASNGAS K HQTVH -- VEEQQSYET P W G E g T LAERMNKLVTDIN V A S NKG L SERF D STIGAGTVLMP 660
Cdd:PLN03206 597 LP pppp A V D L DL E KVLGDMPQ K TFEFK rv ANKLEPLDI P P G I - T VMDALKRVLRLPS V C S KRF L TTKV D RCVTGLVAQQQ 675
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 661 FG G KR Q LT pnmam V A KLP V FGE T --- T T AS A M A W G ------- FN P YI M sknqftg A Y L S V V E S L AK LV A A --- GFEHE KA 727
Cdd:PLN03206 676 TV G PL Q IP ----- L A DVA V IAQ T htg L T GG A C A I G eqpikgl VD P KA M ------- A R L A V G E A L TN LV W A kvt ALSDV KA 743
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 728 YLSFQ e Y FE KL RD E perwgkp A A AVLG A LM A ---- QVD LG AGAI GGKDS M S ---- GSF E DLDV P PT L - IS FA V AVGNMKR 798
Cdd:PLN03206 744 SGNWM - Y AA KL DG E ------- G A DMYD A AV A lrda MIE LG VAID GGKDS L S maaq AGG E VVKA P GN L v IS AY V TCPDITK 815
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 799 ATS P EF K DA D HRIV ---------- R IAPRY LA DGL ------ T PD K D --- A L LEV F SVIEE L TDF ------ HD ala V S TP G 853
Cdd:PLN03206 816 TVT P DL K LG D DGVL lhvdlgkgkr R LGGSA LA QAY dqigdd C PD L D dva Y L KKA F EATQD L IAK rlisag HD --- I S DG G 892
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 854 YGA T A - E AL F KMTL G NRIGVTLNDSI A VDD LF TPAY G s FIV E LADD ------ A KL P A VS nl V EIGE IG TT T SEYV -- F K A 924
Cdd:PLN03206 893 LVV T L l E MA F AGNC G INVDLPSSGHS A FET LF AEEL G - LVL E VSRK nldavm E KL A A AG -- V TAEV IG QV T ASPL ie V K V 969
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 925 A G E T L --- DLDAVQEA WE sgi E SV F PY rskg E DKGATVETIDF -------- H AP K - K TVYVGS -------- SVA KP H V V I 984
Cdd:PLN03206 970 D G A T C lse KTASLRDM WE --- E TS F QL ---- E KLQRLESCVAQ ekeglksr K AP T w K LSFTPA ftdkkimn ATS KP K V A I 1042
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 985 PVFP G N N CEYDS AAAF ER AG A --- DVT tli VNN L TPAAVA estqalvde INKSQIVMIP GGFS GG D EP D g SAK FITAFF R 1061
Cdd:PLN03206 1043 IREE G S N GDREM AAAF YA AG F epw DVT --- MSD L LNGRIS --------- LDDFRGIVFV GGFS YA D VL D - SAK GWAGSI R 1109
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1062 - APAVTEAVRDLLKNR D GLM LG I CNG F Q ALVK LG L VP YGDIVPMTD A C ----- P TLTF N TI GR HQS R LVRTRVAS dl SP - 1134
Cdd:PLN03206 1110 f NEPLLQQFQEFYNRP D TFS LG V CNG C Q LMAL LG W VP GPQVGGGLG A G gdpsq P RFVH N ES GR FEC R FTSVTIED -- SP a 1187
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1135 WLS K TSV G DIHT V AIS HGEGR FVAS DE - VL AQLRANGQIATQ Y V D ET G T P GMDLDV NPNGS L L A I EGIT SPDGR VFGK M G 1213
Cdd:PLN03206 1188 IML K GME G STLG V WAA HGEGR AYFP DE s VL DEVLKSNLAPVR Y C D DD G E P TEQYPF NPNGS P L G I AALC SPDGR HLAM M P 1267
....
gi 499380727 1214 H S ER 1217
Cdd:PLN03206 1268 H P ER 1271
PRK03619
PRK03619 phosphoribosylformylglycinamidine synthase subunit PurQ;
983-1217
2.47e-44
phosphoribosylformylglycinamidine synthase subunit PurQ;
Pssm-ID: 235140 [Multi-domain]
Cd Length: 219
Bit Score: 160.28
E-value: 2.47e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 983 VI p VFPG N NC EY D S A A A FER - A GA DVTTLIVNN ltpaavaestqalv DEINKSQI V MI PGGFS G GD epdgsakfita FF R 1061
Cdd:PRK03619 5 VI - VFPG S NC DR D M A R A LRD l L GA EPEYVWHKE -------------- TDLDGVDA V VL PGGFS Y GD ----------- YL R 58
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1062 AP A ------ VTE AV RDLLK n RDGLM LGICNGFQ A L VKL GL V P y G divpmtdacp T LT F N TIGRHQS R L V RT RV ASDLS P W 1135
Cdd:PRK03619 59 CG A iaafsp IMK AV KEFAE - KGKPV LGICNGFQ I L TEA GL L P - G ---------- A LT R N ASLKFIC R D V HL RV ENNDT P F 126
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1136 L S KTSV G DIHTVA I S HGEG RFV A SD E V L AQ L RA NGQ IATQ Y V DE tgtpgmdldv NPNGS LLA I E GI TSPD G R V F G K M G H S 1215
Cdd:PRK03619 127 T S GYEK G EVIRIP I A HGEG NYY A DE E T L KR L EG NGQ VVFR Y C DE ---------- NPNGS VND I A GI VNEK G N V L G M M P H P 196
..
gi 499380727 1216 ER 1217
Cdd:PRK03619 197 ER 198
FGAM_synth_I
TIGR01737 phosphoribosylformylglycinamidine synthase I; In some species, ...
982-1241
3.93e-44
phosphoribosylformylglycinamidine synthase I; In some species, phosphoribosylformylglycinamidine synthase is composed of a single polypeptide chain. This model describes the PurQ protein of Bacillus subtilis (where PurL, PurQ, and PurS are required for phosphoribosylformylglycinamidine synthase activity) and functionally equivalent proteins from other bacteria and archaea. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273782 [Multi-domain]
Cd Length: 227
Bit Score: 159.85
E-value: 3.93e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 982 V VIPV FPG N NC EY D SAA A FERA G A D vttlivnnlt PAA V AESTQA L V D eink SQI V MI PGGFS G GD EPDGS A kf I T A ff R 1061
Cdd:TIGR01737 3 V AVIR FPG T NC DR D TVY A LRLL G V D ---------- AEI V WYEDGS L P D ---- YDG V VL PGGFS Y GD YLRAG A -- I A A -- A 64
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1062 A P AV t EA VR DLLK nr D G LM - LGICNGFQ A LV KL GL V P ygdivpmtdac PT L TF N TIG R HQS R L V RT RV ASDLSPWLSKTS 1140
Cdd:TIGR01737 65 S P IM - QE VR EFAE -- K G VP v LGICNGFQ I LV EA GL L P ----------- GA L LP N DSL R FIC R W V YL RV ENADTIFTKNYK 130
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1141 V G DIHTVA I S HGEGR FV A S DE V LA Q L RA N G Q IATQ Y V DE T G T pg MDLDV NPNGS LLA I E GI TSPD G R V F G K M G H S ER SGN 1220
Cdd:TIGR01737 131 K G EVIRIP I A HGEGR YY A D DE T LA R L ES N D Q VVFR Y C DE D G D -- VAEEA NPNGS VGN I A GI VNER G N V L G M M P H P ER ASE 208
250 260
....*....|....*....|.
gi 499380727 1221 G L YVNVP G N K yqp I FE AG VE Y 1241
Cdd:TIGR01737 209 K L LGGDD G L K --- L FE SL VE W 226
PRK14090
PRK14090 phosphoribosylformylglycinamidine synthase subunit PurL;
205-802
4.01e-36
phosphoribosylformylglycinamidine synthase subunit PurL;
Pssm-ID: 184499 [Multi-domain]
Cd Length: 601
Bit Score: 146.15
E-value: 4.01e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 205 REPT IT E IKVIDTY WS D HC -- R HT tfgteldevtiddatvkaaf ER Y L amrhelgrdakpvclmdmgtiga KW L K K N G V l 282
Cdd:PRK14090 13 REPT FV E LQAFSVM WS E HC gy S HT -------------------- KK Y I ----------------------- RR L P K T G F - 48
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 283 tgldese E I NA CT V KV kvdvngh D EDWLFL FK N E T HNHP TE IEP FG GAAT CI GG C IRD P L sgrsyvyq AM rvtg A A D PT v 362
Cdd:PRK14090 49 ------- E G NA GV V NL ------- D DYYSIA FK I E S HNHP SA IEP YN GAAT GV GG I IRD V L -------- AM ---- G A R PT - 101
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 363 pvse TLEGK L PQRKLVTTAAA G YSS YGN Q IG LA T G ---- QVDEI Y HPGYVAKRMEV G A V vaa TPADH V RRETPA PG DK I I 438
Cdd:PRK14090 102 ---- AIFDS L HMSRIIDGIIE G IAD YGN S IG VP T V ggel RISSL Y AHNPLVNVLAA G V V --- RNDML V DSKASR PG QV I V 174
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 439 LL GG R TGRDGI G GA TGS S kahnv E S L ELDG A --- EV Q K G NAPV E RK L QRL F RRGDACR L IKRCN D F GAGGV SV A VG EL AD 515
Cdd:PRK14090 175 IF GG A TGRDGI H GA SFA S ----- E D L TGEK A tkl SI Q V G DPFA E KM L IEA F LEMVEEG L VEGAQ D L GAGGV LS A TS EL VA 249
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 516 ---- G LF V D L NT VP KKYEGLDGT E LA ISESQERMAV DVDA E DVDEF L AY A REEN L EATVI A T V TE DP RMVMTWNG D KIVN 591
Cdd:PRK14090 250 kggl G AI V H L DR VP LREPDMEPW E IL ISESQERMAV VTSP E KASRI L EI A KKHL L FGDIV A E V ID DP IYRVMYRD D LVME 329
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 592 LSREF LA sngaskhqtv HVE E QQSY E tp WGE G TLA E RMNKLVTDI N VAS nkg LS E RF D STI G AG TVL M P - FG GK rqltpn 670
Cdd:PRK14090 330 VPVQL LA ---------- NAP E EEIV E -- YTP G EIP E FKRVEFEEV N ARE --- VF E QY D HMV G TD TVL P P g FG AA ------ 388
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 671 m A M VA K LPVFGETT T A S AMAWGF npyims KNQFT G AYLS V V ES LA K LVAA G F E h EK A YLSFQE Y feklr DE P ERWGKPAA 750
Cdd:PRK14090 389 - V M RI K RDGGYSLV T H S RADLAL ------ QDTYW G TFIA V L ES VR K TLSV G A E - PL A ITNCVN Y ----- GD P DVDPVGLS 455
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|...
gi 499380727 751 A VLG AL MAQVDL - G AGAIG G KD S MSGSFEDLDV PPTL ISFAVAVG N MKRATS P 802
Cdd:PRK14090 456 A MMT AL KDACEF s G VPVAS G NA S LYNTYQGKPI PPTL VVGMLGKV N PQKVAK P 508
PRK01175
PRK01175 phosphoribosylformylglycinamidine synthase I; Provisional
980-1217
9.99e-33
phosphoribosylformylglycinamidine synthase I; Provisional
Pssm-ID: 234913 [Multi-domain]
Cd Length: 261
Bit Score: 128.34
E-value: 9.99e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 980 PH V VIPVFP G N NCE YDSAA AF E R A G ADVTTLIV N N L tpaav A ESTQALV D eink SQIVM IPGGFS G GD EPDGS A K F i T A F 1059
Cdd:PRK01175 4 IR V AVLRME G T NCE DETVK AF R R L G VEPEYVHI N D L ----- A AERKSVS D ---- YDCLV IPGGFS A GD YIRAG A I F - A A R 73
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1060 FR A PAVTE a VRDLLK nr D G - LML GICNGFQ A LV K LGL V P YG D IVPMTDAC p T LT F N TIG R HQS R LVRTRVASD l SPWLS K 1138
Cdd:PRK01175 74 LK A VLRKD - IEEFID -- E G y PII GICNGFQ V LV E LGL L P GF D EIAEKPEM - A LT V N ESN R FEC R PTYLKKENR - KCIFT K 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1139 TSVG D IHT V AIS H G EGR F V A S D - E V L AQ L RA N G QI ATQ YVDE T G TPG m DLDV NPNGS LLA I E GIT SPD G R V F G K M G H S ER 1217
Cdd:PRK01175 149 LLKK D VFQ V PVA H A EGR V V F S E e E I L ER L IE N D QI VFR YVDE N G NYA - GYPW NPNGS IYN I A GIT NEK G N V I G L M P H P ER 227
PurL
cd02193 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent ...
312-574
1.04e-30
Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100029 [Multi-domain]
Cd Length: 272
Bit Score: 122.79
E-value: 1.04e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 312 LF K N E T HNHP TE I E P FG GAAT CI GG C IRD PLS - G RS yvyq A MRVTGA A DPTVP vsetl E G KLPQRKLVTT A AA G YSSYG N 390
Cdd:cd02193 4 AM K I E E HNHP AA I D P AA GAAT GV GG A IRD IAA t G ID ---- A KPIALS A NWMAS ----- A G HPGEDAILYD A VK G VAELC N 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 391 Q I GL AT ---------------- GQVD E IY HP gyva KRMEVG A VVAATPAD H VRRETPAP G DKII L L GG RT G RD G I GG ATG 454
Cdd:cd02193 75 Q L GL PI pvgkdrmsmktrwqeg NEQR E MT HP ---- PSLVIS A FGRVRDDR H TLPQLSTE G NALL L I GG GK G HN G L GG TAL 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 455 S S K A HNVE sl E L DGAEV Q KGNAPV E RKLQRLFRRGD A CRLIKRCN D F GAGG VS VA VG EL AD ---- G LF VDL NTVPKKYEG 530
Cdd:cd02193 151 A S V A LSYR -- Q L GDKSA Q VRDPAQ E KGFYEAMQALV A AGKLLAWH D R GAGG LL VA LA EL VF aghc G VQ VDL AALGDDEPD 228
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 499380727 531 LDGT E L A IS ESQER MAVD V D AED V D EFLAYAREENLEAT V IATV 574
Cdd:cd02193 229 MEPL E I A LF ESQER GVIQ V R AED R D AVEEAQYGLADCVH V LGQA 272
AIRS_C
pfam02769 AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression ...
433-584
1.29e-26
AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression/formation protein HypE, AIR synthases EC:6.3.3.1, FGAM synthase EC:6.3.5.3 and selenide, water dikinase EC:2.7.9.3. The function of the C-terminal domain of AIR synthase is unclear, but the cleft formed between N and C domains is postulated as a sulphate binding site.
Pssm-ID: 460684 [Multi-domain]
Cd Length: 152
Bit Score: 107.05
E-value: 1.29e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 433 PGD KI ILLG G rtgr D G IG GA TG S SKAHNV E SLE L DG ae VQ K G NAPV E RK L QRLFRRGD A CR - L I K RCN D FGA GG VSV A VG 511
Cdd:pfam02769 2 PGD VL ILLG S ---- S G LH GA GL S LSRKGL E DSG L AA -- VQ L G DPLL E PT L IYVKLLLA A LG g L V K AMH D ITG GG LAG A LA 75
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499380727 512 E L A D ---- G LFV DL NT VP KKY E GLDGT E LAI SE S Q E R MA V D V DA E DVDEF LA YARE E N LEA T VI AT VT EDP R MVMTW 584
Cdd:pfam02769 76 E M A P asgv G AEI DL DK VP IFE E LMLPL E MLL SE N Q G R GL V V V AP E EAEAV LA ILEK E G LEA A VI GE VT AGG R LTVIV 152
PHA03366
PHA03366 FGAM-synthase; Provisional
678-1207
2.32e-11
FGAM-synthase; Provisional
Pssm-ID: 223058 [Multi-domain]
Cd Length: 1304
Bit Score: 68.51
E-value: 2.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 678 P V FGETTTASAM A W G FNP Y IMSKNQFT GA YLSV VE S L AK L VA A GFEH - E K ---- AYLSFQE yfeklrdeperw GKP AA AV 752
Cdd:PHA03366 682 S V LHPAVPGTCS A L G EQG Y KVQLDPIL GA KYAI VE A L TN L ML A PVAN l E D itit LSVTWPP ------------ TDQ AA SE 749
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 753 L GALM A QV ----- D LG AGAIGGKD S M S GSFEDLDV P PT L ISFA V AVGN ------ MK R A T s P EF K DADHRI -- VR I A P R Y L 819
Cdd:PHA03366 750 L YRAL A AC kefcr E LG VNFTFTSA S S S PRQDQPPQ P GP L FNTI V FTAS apvpss TP R L T - P DL K KPGSAL vh LS I S P E Y T 828
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 820 AD G -------------- LTPDKDA L LEV F SVIEE L td FHDA L A VS tp G Y ---- G ATAEA L FK M T L - G N R i GVT LN --- DS 877
Cdd:PHA03366 829 LA G svfeqifglksgtl PDISPSY L KNL F RAVQH L -- ISEG L V VS -- G H dvsd G GLIAC L AE M A L a G G R - GVT IT vpa GE 903
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 878 IAVDD LF TPAY G s FIV E L a DDAK L P AV ------ S N LV -- E IG EI G TTTSEYV F -- KAA G ET L --- D L DAVQEA W E S GIES 944
Cdd:PHA03366 904 DPLQF LF SETP G - VVI E V - PPSH L S AV ltrlrs R N II cy P IG TV G PSGPSNT F sv SHN G TV L fre S L SSLRST W R S FSDE 981
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 945 V F PYRSKG -------- E D K G A tv ETI D FHAPK ------- KTV Y VGSS va K P H - V VIPVF PG NNCEYDSA AAF ER AG A D VT 1008
Cdd:PHA03366 982 Q F ELLRPD lteesmyr K D Y G N -- NEV D LGPLE eglttsp LRL Y TCPD -- K R H r V AVLLL PG CPGPHALL AAF TN AG F D PY 1057
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1009 TL ivnnltpaavaestqa LVD E INKSQIV ----- MIP GG F SG GDEPDGS A K - FIT A FFRA PAV TE A VRDL L KNR D GLM LG 1082
Cdd:PHA03366 1058 PV ---------------- SIE E LKDGTFL defsg LVI GG S SG AEDSYTG A R a AVA A LLSN PAV RD A LLRF L NRP D TFS LG 1121
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 1083 ICN - G F Q A L VK L GL V ------ P YGDIVPMTDACP TL TF N TI G RHQ SR LVRTRV asdls P WLS K t SV G -- DIH - T V AISHG 1152
Cdd:PHA03366 1122 CGE l G C Q I L FA L KA V gstaps P VPGTETEEQWPI TL EP N AS G LYE SR WLNFYI ----- P ETT K - SV A lr PLR g S V LPCWA 1195
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499380727 1153 E G RFVA ---- S D EVLAQ LR AN GQIA TQYVDETGT PG --- MDLDV NP N G S l LAIE G IT S P DGR 1207
Cdd:PHA03366 1196 Q G THLG fryp N D GMEYI LR NS GQIA ATFHGADVD PG npa RHYPR NP T G N - SNVA G LC S A DGR 1256
PurM-like
cd00396 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen ...
312-573
1.22e-09
AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain of AIR synthase forms the dimer interface of the protein, and is suggested as a putative ATP binding domain.
Pssm-ID: 100027 [Multi-domain]
Cd Length: 222
Bit Score: 59.72
E-value: 1.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 312 LFKNETH N H P TE I E P FG G AATCI GG CIR D PL sgrsy VYQ A MRVTGA A DPTVPVSETLEG klpqrkl VTTAAA G YSSYG NQ 391
Cdd:cd00396 3 AMSTDGI N P P LA I N P WA G GRLAV GG AVN D IA ----- AMG A RPIALL A SLSLSNGLEVDI ------- LEDVVD G VAEAC NQ 70
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 392 I G LATGQVDEIYH PG YVAKRMEVGAVVAA - TPA D H V RRETP A - PGD KI IL lggr TG R D GIGGATGSSKA H NVE sleldga 469
Cdd:cd00396 71 L G VPIVGGHTSVS PG TMGHKLSLAVFAIG v VEK D R V IDSSG A r PGD VL IL ---- TG V D AVLELVAAGDV H AMH ------- 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 470 evqkgnapverklqrlfrrgdacrlikrcn D FGA GG VSVAVG ELA D ---- G LFV DL NTV P ----- KKYEGLDGT E LAISE 540
Cdd:cd00396 140 ------------------------------ D ITD GG LLGTLP ELA Q asgv G AEI DL EAI P ldevv RWLCVEHIE E ALLFN 189
250 260 270
....*....|....*....|....*....|...
gi 499380727 541 S QERMAVD V D AE DV D EF L AYAREENLE A T VI AT 573
Cdd:cd00396 190 S SGGLLIA V P AE EA D AV L LLLNGNGID A A VI GR 222
FGAR-AT_linker
pfam18072 Formylglycinamide ribonucleotide amidotransferase linker domain; This is the linker domain ...
183-225
5.94e-08
Formylglycinamide ribonucleotide amidotransferase linker domain; This is the linker domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT), also known as Phosphoribosylformylglycinamidine synthase (EC:6.3.5.3), PurL and formylglycinamidine ribonucleotide (FGAM) synthase. This enzyme catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway. The structure analysis of Salmonella typhimurium FGAR-AT reveals that this linker domain is made up of a long hydrophilic belt with an extended conformation.
Pssm-ID: 465632 [Multi-domain]
Cd Length: 50
Bit Score: 50.16
E-value: 5.94e-08
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 499380727 183 ER GLA MDLADLEFCQK YF SEES R E PT IT E IKVIDTY WS D HCRH 225
Cdd:pfam18072 7 YL GLA LSDDEIDYLVE YF AGLG R N PT DV E LGMFAQM WS E HCRH 49
GATase1
cd01653 Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase ...
982-1091
1.74e-06
Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase (GATase1)-like domain. This group includes proteins similar to Class I glutamine amidotransferases, the intracellular PH1704 from Pyrococcus horikoshii, the C-terminal of the large catalase: Escherichia coli HP-II, Sinorhizobium meliloti Rm1021 ThuA. and, the A4 beta-galactosidase middle domain. The majority of proteins in this group have a reactive Cys found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For Class I glutamine amidotransferases proteins which transfer ammonia from the amide side chain of glutamine to an acceptor substrate, this Cys forms a Cys-His-Glu catalytic triad in the active site. Glutamine amidotransferases activity can be found in a range of biosynthetic enzymes included in this cd: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase, anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. For Pyrococcus horikoshii PH1704, the Cys of the nucleophile elbow together with a different His and, a Glu from an adjacent monomer form a catalytic triad different from the typical GATase1 triad. The E. coli HP-II C-terminal domain, S. meliloti Rm1021 ThuA and the A4 beta-galactosidase middle domain lack the catalytic triad typical GATaseI domains. GATase1-like domains can occur either as single polypeptides, as in Class I glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.
Pssm-ID: 153210 [Multi-domain]
Cd Length: 115
Bit Score: 47.98
E-value: 1.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 982 V VIPV FPG NNCE -- YDSAA A FER AGA D V T tl I V NNLTPAAVAESTQALV D einksq IVMI PGG FSGG D epdgsakfit AF 1059
Cdd:cd01653 1 V AVLL FPG FEEL el ASPLD A LRE AGA E V D -- V V SPDGGPVESDVDLDDY D ------ GLIL PGG PGTP D ---------- DL 62
90 100 110
....*....|....*....|....*....|..
gi 499380727 1060 F R AP A VTEAV R DLLK n RDGLM LGIC N G F Q A LV 1091
Cdd:cd01653 63 A R DE A LLALL R EAAA - AGKPI LGIC L G A Q L LV 93
GAT_1
cd03128 Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase ...
982-1090
2.39e-05
Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase (GATase1)-like domain. This group contains proteins similar to Class I glutamine amidotransferases, the intracellular PH1704 from Pyrococcus horikoshii, the C-terminal of the large catalase: Escherichia coli HP-II, Sinorhizobium meliloti Rm1021 ThuA, the A4 beta-galactosidase middle domain and peptidase E. The majority of proteins in this group have a reactive Cys found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For Class I glutamine amidotransferases proteins which transfer ammonia from the amide side chain of glutamine to an acceptor substrate, this Cys forms a Cys-His-Glu catalytic triad in the active site. Glutamine amidotransferases activity can be found in a range of biosynthetic enzymes included in this cd: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase, anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase (CPSase), cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. For Pyrococcus horikoshii PH1704, the Cys of the nucleophile elbow together with a different His and, a Glu from an adjacent monomer form a catalytic triad different from the typical GATase1 triad. Peptidase E is believed to be a serine peptidase having a Ser-His-Glu catalytic triad which differs from the Cys-His-Glu catalytic triad of typical GATase1 domains, by having a Ser in place of the reactive Cys at the nucleophile elbow. The E. coli HP-II C-terminal domain, S. meliloti Rm1021 ThuA and the A4 beta-galactosidase middle domain lack the catalytic triad typical GATaseI domains. GATase1-like domains can occur either as single polypeptides, as in Class I glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase. Peptidase E has a circular permutation in the common core of a typical GTAse1 domain.
Pssm-ID: 153222 [Multi-domain]
Cd Length: 92
Bit Score: 44.11
E-value: 2.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 982 V VIPV F P G NNCEYDS -- AA A FER AGA D V T tl I V NNLTPAAVAESTQALV D einksq IVMI PGG FSGG D epdgsakfit AF 1059
Cdd:cd03128 1 V AVLL F G G SEELELA sp LD A LRE AGA E V D -- V V SPDGGPVESDVDLDDY D ------ GLIL PGG PGTP D ---------- DL 62
90 100 110
....*....|....*....|....*....|.
gi 499380727 1060 FRAP A VTEAV R DLLK n RDGLM LGIC N G F Q A L 1090
Cdd:cd03128 63 AWDE A LLALL R EAAA - AGKPV LGIC L G A Q L L 92
PurL_repeat2
cd02204 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. ...
417-574
2.79e-05
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100035 [Multi-domain]
Cd Length: 264
Bit Score: 47.14
E-value: 2.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 417 VV A ATPA D H VR R ---- ETPAP GD KII L L G gr TGR D GI GG ATGSSKA H NVE sleld G AEVQKGNAPV E RK L QRLFRRGDAC 492
Cdd:cd02204 114 IG A VGVV D D VR K ivtl DFKKE GD LLY L I G -- ETK D EL GG SEYALAY H GLG ----- G GAPPLVDLER E KA L FDAVQELIKE 186
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499380727 493 R L IKRCN D FGA GG VS VA VG E L A D ---- G LF VDL NTVPKK yegldg T EL AI SES QE R MA V D V DA E DVDE F L ay A R E ENLE A 568
Cdd:cd02204 187 G L VLSAH D VSD GG LA VA LA E M A F aggl G AE VDL SKDDAE ------ D EL LF SES LG R VL V E V KP E NEEV F E -- A E E AGVP A 258
....*.
gi 499380727 569 TVI A TV 574
Cdd:cd02204 259 TVI G TV 264
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
