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Conserved domains on  [gi|499349259|ref|WP_011038552|]
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CsgG/HfaB family protein [Xanthomonas campestris]

Protein Classification

CsgG/HfaB family protein( domain architecture ID 10003703)

CsgG/HfaB family protein similar to Caulobacter HfaB, which is involved in attachment of the holdfast, a polysaccharide complex adhesive organelle, to the cell, and to CsgG, a lipoprotein that forms a secretion channel for curli subunits, functional amyloids involved in biofilm formation, in the outer membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CsgG COG1462
Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope ...
 1-251 1.22e-34

Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 441071 [Multi-domain]  Cd Length: 263  Bit Score: 127.05  E-value: 1.22e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349259   1 MSKTISVSAAVLSSVLGIA-LASVSAPASAGLKDAFKGSAQDQRKDAVAQIPVCAKPlgSLSVIEPEDAVNW---WSGQQ 76
Cdd:COG1462    1 MKKSILALLLLALLALLLAgCATTESSTPVEVEPPVLANATPYAQDLVALPYPGPKP--RVAVGDFDDQTGQngsSGSDA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349259  77 L-PAPSKLIKVFVNRSRCFTLVDRgAGMAASQRERDMAANGDLRARSNMGKGQIRAADYVMTPDLISQNRNAGGSAIAGM 155
Cdd:COG1462   79 VgQGASDMLITALQQSGRFTVVER-ENLSNLLAERKLAGSGRIRAGTAAQLGQLLGADYLITGGITEFDRNTSGGGGGAR 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349259 156 LGGLVGGNagnlvgglNLSKKTADVVLTITDVRSSEQVAMAEGNAKKTDLGWGARGNVFGGSDYGAAGAGGYANTEIGQV 235
Cdd:COG1462  158 LFGIGGSG--------KYQVAYVTVDLRLVDVRTGEVVYSVTGSGEISSSEVSAGGFGFVGGGLLEAGTGGYDNTPNGKA 229

                        250
                 ....*....|....*.
gi 499349259 236 ITLAYLQAYTDIVSQL 251
Cdd:COG1462  230 VRAAIEEAVNNLVAGL 245
 
Name Accession Description Interval E-value
CsgG COG1462
Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope ...
 1-251 1.22e-34

Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441071 [Multi-domain]  Cd Length: 263  Bit Score: 127.05  E-value: 1.22e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349259   1 MSKTISVSAAVLSSVLGIA-LASVSAPASAGLKDAFKGSAQDQRKDAVAQIPVCAKPlgSLSVIEPEDAVNW---WSGQQ 76
Cdd:COG1462    1 MKKSILALLLLALLALLLAgCATTESSTPVEVEPPVLANATPYAQDLVALPYPGPKP--RVAVGDFDDQTGQngsSGSDA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349259  77 L-PAPSKLIKVFVNRSRCFTLVDRgAGMAASQRERDMAANGDLRARSNMGKGQIRAADYVMTPDLISQNRNAGGSAIAGM 155
Cdd:COG1462   79 VgQGASDMLITALQQSGRFTVVER-ENLSNLLAERKLAGSGRIRAGTAAQLGQLLGADYLITGGITEFDRNTSGGGGGAR 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349259 156 LGGLVGGNagnlvgglNLSKKTADVVLTITDVRSSEQVAMAEGNAKKTDLGWGARGNVFGGSDYGAAGAGGYANTEIGQV 235
Cdd:COG1462  158 LFGIGGSG--------KYQVAYVTVDLRLVDVRTGEVVYSVTGSGEISSSEVSAGGFGFVGGGLLEAGTGGYDNTPNGKA 229

                        250
                 ....*....|....*.
gi 499349259 236 ITLAYLQAYTDIVSQL 251
Cdd:COG1462  230 VRAAIEEAVNNLVAGL 245
CsgG pfam03783
Curli production assembly/transport component CsgG; CsgG is an outer membrane-located ...
 89-254 6.91e-08

Curli production assembly/transport component CsgG; CsgG is an outer membrane-located lipoprotein that is highly resistant to protease digestion. During curli assembly, an adhesive surface fibre, CsgG is required to maintain the stability of CsgA and CsgB.


Pssm-ID: 427502  Cd Length: 209  Bit Score: 52.02  E-value: 6.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349259   89 NRSRCFTLVDRgAGMAASQRERDMAANGDLRARSNMGKGQIRAADYVMTPDLISQNRNAGGSaiagmlgglvGGNAGNLV 168
Cdd:pfam03783  48 VKSGWFRVLER-EGLQNLLTEQKLGRSGRIDPNTAAQLGKLTGADYLVEGSITAYDTNVSTG----------GGGARYLG 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349259  169 GGLNLSKKTADVVLTI--TDVRSSEQVAMAEGNAKKTDLGWGARGNVFGGSDYGAAGAGGYANTEIGQVITLAYLQAYTD 246
Cdd:pfam03783 117 IGASSKYREAQVAVDLrlVDVRTGEVLASVTGTGTSSSSEARAGVFRFIGKGLLGGEAGSTSNEPVGLAVRAAIEQAVKY 196


                  ....*...
gi 499349259  247 IVSQLGGL 254
Cdd:pfam03783 197 LITGIERG 204
 
Name Accession Description Interval E-value
CsgG COG1462
Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope ...
 1-251 1.22e-34

Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441071 [Multi-domain]  Cd Length: 263  Bit Score: 127.05  E-value: 1.22e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349259   1 MSKTISVSAAVLSSVLGIA-LASVSAPASAGLKDAFKGSAQDQRKDAVAQIPVCAKPlgSLSVIEPEDAVNW---WSGQQ 76
Cdd:COG1462    1 MKKSILALLLLALLALLLAgCATTESSTPVEVEPPVLANATPYAQDLVALPYPGPKP--RVAVGDFDDQTGQngsSGSDA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349259  77 L-PAPSKLIKVFVNRSRCFTLVDRgAGMAASQRERDMAANGDLRARSNMGKGQIRAADYVMTPDLISQNRNAGGSAIAGM 155
Cdd:COG1462   79 VgQGASDMLITALQQSGRFTVVER-ENLSNLLAERKLAGSGRIRAGTAAQLGQLLGADYLITGGITEFDRNTSGGGGGAR 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349259 156 LGGLVGGNagnlvgglNLSKKTADVVLTITDVRSSEQVAMAEGNAKKTDLGWGARGNVFGGSDYGAAGAGGYANTEIGQV 235
Cdd:COG1462  158 LFGIGGSG--------KYQVAYVTVDLRLVDVRTGEVVYSVTGSGEISSSEVSAGGFGFVGGGLLEAGTGGYDNTPNGKA 229

                        250
                 ....*....|....*.
gi 499349259 236 ITLAYLQAYTDIVSQL 251
Cdd:COG1462  230 VRAAIEEAVNNLVAGL 245
CsgG pfam03783
Curli production assembly/transport component CsgG; CsgG is an outer membrane-located ...
 89-254 6.91e-08

Curli production assembly/transport component CsgG; CsgG is an outer membrane-located lipoprotein that is highly resistant to protease digestion. During curli assembly, an adhesive surface fibre, CsgG is required to maintain the stability of CsgA and CsgB.


Pssm-ID: 427502  Cd Length: 209  Bit Score: 52.02  E-value: 6.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349259   89 NRSRCFTLVDRgAGMAASQRERDMAANGDLRARSNMGKGQIRAADYVMTPDLISQNRNAGGSaiagmlgglvGGNAGNLV 168
Cdd:pfam03783  48 VKSGWFRVLER-EGLQNLLTEQKLGRSGRIDPNTAAQLGKLTGADYLVEGSITAYDTNVSTG----------GGGARYLG 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349259  169 GGLNLSKKTADVVLTI--TDVRSSEQVAMAEGNAKKTDLGWGARGNVFGGSDYGAAGAGGYANTEIGQVITLAYLQAYTD 246
Cdd:pfam03783 117 IGASSKYREAQVAVDLrlVDVRTGEVLASVTGTGTSSSSEARAGVFRFIGKGLLGGEAGSTSNEPVGLAVRAAIEQAVKY 196


                  ....*...
gi 499349259  247 IVSQLGGL 254
Cdd:pfam03783 197 LITGIERG 204
LpoB pfam13036
Peptidoglycan-synthase activator LpoB; This is a family of Gram-negative bacterial outer ...
 84-150 9.06e-03

Peptidoglycan-synthase activator LpoB; This is a family of Gram-negative bacterial outer membrane lipoproteins. LpoB is required for the function of the major peptidoglycan synthase enzyme PBP1B. It interacts with PBP1B protein via the UvrB-like non-catalytic domain on that protein. LpoB has a 54-aa-long flexible N-terminal stretch followed by a globular domain with similarity to the N-terminal domain of the prevalent periplasmic protein TolB. The long, flexible N-terminal region of LpoB enables it to span the periplasm and reach its docking site in PBP1B. Peptidoglycan is the essential polymer within the sacculus that surrounds the cytoplasmic membrane of bacteria.


Pssm-ID: 463777  Cd Length: 147  Bit Score: 36.13  E-value: 9.06e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499349259   84 IKVFVNRSRCFTLVDRGAGMAASQRERDMAANGDLRARSNMGKGQIRAADYVMTPDlISQNRNAGGS 150
Cdd:pfam13036  54 IRRALIKSGKFRFVDGAQRQDAREELRLQQDSGLVDQSTAAKIGRLIGADYSLSGK-INSIVKAEGG 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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