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Conserved domains on  [gi|499320392|ref|WP_011010884|]
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sugar ABC transporter permease [Clostridium perfringens]

Protein Classification

sugar ABC transporter permease( domain architecture ID 10790449)

sugar ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of sugar substrates including oligosaccharides and maltodextrin

Gene Ontology:  GO:0043190|GO:0140359|GO:0042626|GO:0016020|GO:0008643
PubMed:  25750732|24638992|18535149|17723295
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 18-297 1.02e-109

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


:

Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 319.40  E-value: 1.02e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  18 KYERKLRPAERRMAWISRIFIWFMLLVVLFPVFAVVSASMAKGEVFTQTTLIPSAFTLENYSKVLTETNFLIWVKNSLII 97
Cdd:COG3833    2 SRRKSRKRRRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLYSSSLIPENFTLENYKKLFTETPFLRWFLNSLIV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  98 CVVVSVIQLLLTVPMAFAFSRLKFWGRKNGLMMLLLLQMFPAAMSLPAILALAYRLDGMDHIITLIIVQ-AGAGAFNIWL 176
Cdd:COG3833   82 AVVTAIISVFLAALAAYAFSRFRFKGRKAGLLALLLLQMFPAFLALVALYLLLSALGLLNTLLGLILVYlGGAIPFNTWL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 177 LKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEFVFASALLKSPESLTLAVGMQQFITNN 256
Cdd:COG3833  162 MKGYFDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYSFVSDQ 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 499320392 257 FSANWTQYSAAAIMASIPIVAFATIAQKYMAKGLTAGSVKG 297
Cdd:COG3833  242 RNTNWGVFAAGAVLVAIPIVILFLFLQRYLVSGLTAGGVKG 282
 
Name Accession Description Interval E-value
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 18-297 1.02e-109

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 319.40  E-value: 1.02e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  18 KYERKLRPAERRMAWISRIFIWFMLLVVLFPVFAVVSASMAKGEVFTQTTLIPSAFTLENYSKVLTETNFLIWVKNSLII 97
Cdd:COG3833    2 SRRKSRKRRRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLYSSSLIPENFTLENYKKLFTETPFLRWFLNSLIV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  98 CVVVSVIQLLLTVPMAFAFSRLKFWGRKNGLMMLLLLQMFPAAMSLPAILALAYRLDGMDHIITLIIVQ-AGAGAFNIWL 176
Cdd:COG3833   82 AVVTAIISVFLAALAAYAFSRFRFKGRKAGLLALLLLQMFPAFLALVALYLLLSALGLLNTLLGLILVYlGGAIPFNTWL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 177 LKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEFVFASALLKSPESLTLAVGMQQFITNN 256
Cdd:COG3833  162 MKGYFDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYSFVSDQ 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 499320392 257 FSANWTQYSAAAIMASIPIVAFATIAQKYMAKGLTAGSVKG 297
Cdd:COG3833  242 RNTNWGVFAAGAVLVAIPIVILFLFLQRYLVSGLTAGGVKG 282
malG PRK10998
maltose ABC transporter permease MalG;
32-297 2.30e-53

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 176.05  E-value: 2.30e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  32 WISRIFIWFMLLVVLFPVFAVVSASMAKGEvFTQTTLIPSAFTLENYSKVL-------------TETNFLIWVKNSLIIC 98
Cdd:PRK10998  14 FATHLLLLGFIALIMFPLLMVIAISLREGN-FATGSLIPEQISWEHWKLALgfsvehadgrvtpPPFPVLLWLWNSVKVA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  99 VVVSVIQLLLTVPMAFAFSRLKFWGRKNGLMMLLLLQMFPAAMSLPAILALAYRLD------GMDHIITLIIVQAGAGAF 172
Cdd:PRK10998  93 GITAIGIVALSTTCAYAFARMRFKGKATLLKGMLIFQMFPAVLSLVALYALFDRLGqyipfiGLNTHGGVIFAYLGGIAL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 173 NIWLLKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEFVFASALLKSPESLTLAVGMQQF 252
Cdd:PRK10998 173 HVWTIKGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASLLLRDVNSYTLAVGMQQY 252

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 499320392 253 ItNNFSANWTQYSAAAIMASIPIVAFATIAQKYMAKGLTAGSVKG 297
Cdd:PRK10998 253 L-NPQNYLWGDFAAAAVLSAIPITVVFLLAQRWLVGGLTAGGVKG 296
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 93-276 2.30e-13

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 67.30  E-value: 2.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  93 NSLIICVVVSVIQLLLTVPMAFAFSRLKFWGRKNGLMMLLLLQMFPAAMSLPAILALAYRLDGMDHII-----TLIIVQA 167
Cdd:cd06261    3 NTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPglglpALILALL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 168 GAGAFNIWLLKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEFVFASALLkSPESLTLAV 247
Cdd:cd06261   83 LIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLG-GGEAPGPGT 161

                        170       180
                 ....*....|....*....|....*....
gi 499320392 248 GMQQFITNNFSANWTQYSAAAIMASIPIV 276
Cdd:cd06261  162 GLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 146-290 3.82e-08

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 52.30  E-value: 3.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  146 ILALAYRLDGMDHIITLIIVQA--GAGAFNIWLLKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTF 223
Cdd:pfam00528  38 LLVVIAILSILGHGILPAIILAllGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAF 117

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499320392  224 IGAYSEFVFASALLKSPeslTLAVGMQQFITNNFSANWTQYSAAAIMASIPIVAFATIAQKYMAKGL 290
Cdd:pfam00528 118 GGALGGAVLLEFLGSWP---GLGLLLIEAILGYDYPEIQGPVLAAALILLLLNLLVDILQRLLDPRV 181
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 36-230 1.47e-03

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 40.05  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392   36 IFIWFMLLVVLFPVFAVVSASMAKGEvftqttliPSAFTLENYSKVLTETNFLIWVKNSLIICVVVSVIqlllTVPMAFA 115
Cdd:TIGR03262   9 GMILALLLFLLLPLLALLTKSVYDSD--------GDFIGLANFAEYFATPGLLQSLGNSLTVSAIVTAI----VVPLAFA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  116 F------SRLKFwgrKNGLMMLLLLQMFPAAMsLPAIlALAYRLDGMDhiitliIVQAGAGAFNIW-------------- 175
Cdd:TIGR03262  77 FayaltrSRIPG---KGAFRLVALLPLLAPSL-LPAI-SLIYLFGNQG------LLKGLLGGFSIYgfwgivigevfytf 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  176 -----LLKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEF 230
Cdd:TIGR03262 146 phalmILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTLVITDF 205
 
Name Accession Description Interval E-value
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 18-297 1.02e-109

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 319.40  E-value: 1.02e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  18 KYERKLRPAERRMAWISRIFIWFMLLVVLFPVFAVVSASMAKGEVFTQTTLIPSAFTLENYSKVLTETNFLIWVKNSLII 97
Cdd:COG3833    2 SRRKSRKRRRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLYSSSLIPENFTLENYKKLFTETPFLRWFLNSLIV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  98 CVVVSVIQLLLTVPMAFAFSRLKFWGRKNGLMMLLLLQMFPAAMSLPAILALAYRLDGMDHIITLIIVQ-AGAGAFNIWL 176
Cdd:COG3833   82 AVVTAIISVFLAALAAYAFSRFRFKGRKAGLLALLLLQMFPAFLALVALYLLLSALGLLNTLLGLILVYlGGAIPFNTWL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 177 LKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEFVFASALLKSPESLTLAVGMQQFITNN 256
Cdd:COG3833  162 MKGYFDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYSFVSDQ 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 499320392 257 FSANWTQYSAAAIMASIPIVAFATIAQKYMAKGLTAGSVKG 297
Cdd:COG3833  242 RNTNWGVFAAGAVLVAIPIVILFLFLQRYLVSGLTAGGVKG 282
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 32-297 3.90e-70

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 218.43  E-value: 3.90e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  32 WISRIFIWFMLLVVLFPVFAVVSAS-MAKGEVFTQT-TLIPSAFTLENYSKVLTETNFLIWVKNSLIICVVVSVIQLLLT 109
Cdd:COG0395   15 ILLYLLLILLALLFLFPLYWMVVTSfKPPAEIFSGPpSLLPSEFTLENYRAAFTDGPFGRYLLNSLIVAVVSTVLSLLLS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 110 VPMAFAFSRLKFWGRKNGLMMLLLLQMFPAAMSLPAILALAYRLDGMDHIITLIIVQAGAG-AFNIWLLKGAIDGIPKEL 188
Cdd:COG0395   95 SLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAFGlPFGIFLLRQFFRSIPREL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 189 TEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEFVFASALLKSPESLTLAVGMQQFITnNFSANWTQYSAAA 268
Cdd:COG0395  175 EEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQG-QYGTDWGLLMAAA 253

                        250       260
                 ....*....|....*....|....*....
gi 499320392 269 IMASIPIVAFATIAQKYMAKGLTAGSVKG 297
Cdd:COG0395  254 VIATLPVLILFLFLQRYFVRGLTAGAVKG 282
malG PRK10998
maltose ABC transporter permease MalG;
32-297 2.30e-53

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 176.05  E-value: 2.30e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  32 WISRIFIWFMLLVVLFPVFAVVSASMAKGEvFTQTTLIPSAFTLENYSKVL-------------TETNFLIWVKNSLIIC 98
Cdd:PRK10998  14 FATHLLLLGFIALIMFPLLMVIAISLREGN-FATGSLIPEQISWEHWKLALgfsvehadgrvtpPPFPVLLWLWNSVKVA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  99 VVVSVIQLLLTVPMAFAFSRLKFWGRKNGLMMLLLLQMFPAAMSLPAILALAYRLD------GMDHIITLIIVQAGAGAF 172
Cdd:PRK10998  93 GITAIGIVALSTTCAYAFARMRFKGKATLLKGMLIFQMFPAVLSLVALYALFDRLGqyipfiGLNTHGGVIFAYLGGIAL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 173 NIWLLKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEFVFASALLKSPESLTLAVGMQQF 252
Cdd:PRK10998 173 HVWTIKGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASLLLRDVNSYTLAVGMQQY 252

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 499320392 253 ItNNFSANWTQYSAAAIMASIPIVAFATIAQKYMAKGLTAGSVKG 297
Cdd:PRK10998 253 L-NPQNYLWGDFAAAAVLSAIPITVVFLLAQRWLVGGLTAGGVKG 296
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 27-289 6.50e-28

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 108.28  E-value: 6.50e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  27 ERRMAWISRIFIWFMLLVVLFPVFAVVSASMAKGEVFTqttLIPSAFTLENYSKVLTETNFLIWVKNSLIICVVVSVIQL 106
Cdd:COG1177    2 SRLGRLLLRLFLALVLLFLYLPILVLVLYSFNDSWFLT---FPPEGFTLRWYAELFSDPRLLDALLNSLLIALLSTLLAT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 107 LLTVPMAFAFSRLKFWGRKnglmmlLLLQMFPAAMSLP------AILALAYRLDGMDHIITLIIVQ-AGAGAFNIWLLKG 179
Cdd:COG1177   79 VLGTPAALALARYRFRGRR------LLLALLLLPLVVPgivlgvALLLLFSALGLSGGLWGLILAHvVFTLPFVVLVVLA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 180 AIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEFVFASaLLKSPESLTLAVGMQQFITNNFSA 259
Cdd:COG1177  153 RLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFTLSFDEFVITL-FLAGPGVTTLPVYIYSMIRRGISP 231

                        250       260       270
                 ....*....|....*....|....*....|
gi 499320392 260 nwtQYSAAAIMASIPIVAFATIAQKYMAKG 289
Cdd:COG1177  232 ---EINALSTLLILLSLLLLLLAERLRRRG 258
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
21-282 5.85e-19

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 86.75  E-value: 5.85e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  21 RKLRPAERRMAWISRIFIWFMLLVVLFPVFAVVSASMakgevftqTTLIPSAFTLENYSKVLTETNFLIWVKNSLIICVV 100
Cdd:COG1178  278 PRRVKLGRWRWLALALCLLLVLLGLLLPLLALLLWSL--------TKALDDNLTLDNYRFVLLDPSLLRALLNSLLLALL 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 101 VSVIQLLLTVPMAFAFSRLKFWGRKnglmMLLLLQMFPAAMSlPAILALAY-----RLDGMDHIITLIIVQAG----AGA 171
Cdd:COG1178  350 AALLAVLLALLLAYLVRRRRGRLAR----LLDRLAMLPYAVP-GIVLGLGLlllfnRPLPLLLYGTLAILVLAyvvrFLP 424

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 172 FNIWLLKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEFVfASALLKSPESLTLAVGMQQ 251
Cdd:COG1178  425 FALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELS-ATLLLRPPGFETLAVLIYQ 503

                        250       260       270
                 ....*....|....*....|....*....|.
gi 499320392 252 FITNNfsanwtQYSAAAIMASIpIVAFATIA 282
Cdd:COG1178  504 LASSG------RYGEAAALALL-LVLVSLLP 527
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
24-289 2.12e-16

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 77.48  E-value: 2.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  24 RPAERRMAWISRIFIW----FMLLVVLFPVFAVVSASmakgevFTQTTLIPSAFT---LENYSKVLTETNFLIWVKNSLI 96
Cdd:COG1175   10 RRRRRRRRLAAYLFLLpallLLLVFVLYPLLYTLYLS------FTDWNLLGPPPEfvgLDNYARLFTDPRFWNALGNTLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  97 ICVVVSVIQLLLTVPMAFAFSRlKFWGRKnglmMLLLLQMFPAAMSlPAILALAYR------------------LDGMDH 158
Cdd:COG1175   84 FTVVSVPLQLVLGLLLALLLNR-KLRGRG----FFRTLFFLPWVIS-PVVVALIWKwlfnpdygllnallgalgLEPINW 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 159 -------IITLIIVQ--AGAGaFNIWLLKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSE 229
Cdd:COG1175  158 lgdpslaLPAVIIVTvwKGTG-FNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQV 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499320392 230 FVFASALLK---SPESLTLAVGMQQ--FITNNFSanwtqY-SAAAIMASIPIVAFATIAQKYMAKG 289
Cdd:COG1175  237 FDLVYVLTGggpGNSTTTLVLYIYQtaFQQFDFG-----YaSAIAVVLFLIILVLTLLQLRLLRRR 297
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
42-290 5.64e-15

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 73.23  E-value: 5.64e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  42 LLVVLFPVF-AVVSASMAKGEVFT-QTTLIPSAFTLENYSKVLTE------TNFLIWVKNSLIICVVVSVIQLLLTVPMA 113
Cdd:PRK10973  20 IAVILFPLYvAFVAATLDKQAVFAvPMTLIPGTHLLENIANIWVNgvgnnsAPFGRMLLNSFVMAFSITVGKITVSMLSA 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 114 FAFSRLKFWGRKNGLMMLLLLQMFPAAMSLPAILALAYRLDGMDHIITLII-VQAGAGAfnIWLLKGAIDGIPKELTEAA 192
Cdd:PRK10973 100 FAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLpLMASATA--TFLFRQFFMTLPDELVEAA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 193 YVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEFVFASALLKSPESLTLAVGMQQFITNNFSAN-WTQYSAAAIMA 271
Cdd:PRK10973 178 RIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLIITDVSLGTAVAGIKGMIATGEGTTeWNQVMAAMLLT 257

                        250
                 ....*....|....*....
gi 499320392 272 SIPIVAFATIAQKYMAKGL 290
Cdd:PRK10973 258 LIPPVVIVLAMQRAFVRGL 276
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 21-294 6.68e-15

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 73.26  E-value: 6.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  21 RKLRPAERRMAWISRIFIWFMLLVVLfPVFAVVSASMAkgeVFTQTTLIPSAFTLENYSKVLTETNFLIWVKNSLIICVV 100
Cdd:COG1176    3 AALRRRLRPLLLLLPALLWLLLFFVL-PLLLLLVYSFT---TRDPYGGVVPGFTLENYARLFTDPLYLKVLLRTLWIALL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 101 VSVIQLLLTVPMAFAFSRLKFWGRKnglmMLLLLQMFP------------------------AAMSLPAI---LALAYRL 153
Cdd:COG1176   79 TTLICLLLGYPIAYFLARAPPRWRN----LLLLLVILPfwtsflvrtyawivllgrngllnsLLLALGLIdepLRLLYTE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 154 DGMdhIITLIIVQAgagAFNIWLLKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEFVfA 233
Cdd:COG1176  155 FAV--VIGLVYVYL---PFMVLPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFV-T 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499320392 234 SALLKSPESLTLAVGMQQFITNNFsaNWTQYSAAAIMASIPIVAFATIAQKYMAKGLTAGS 294
Cdd:COG1176  229 PALLGGGKVLMIGNLIYQQFLSAL--NWPLAAALAVVLLLIVLLVLLLYLRLLRRRRLLGG 287
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 93-276 2.30e-13

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 67.30  E-value: 2.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  93 NSLIICVVVSVIQLLLTVPMAFAFSRLKFWGRKNGLMMLLLLQMFPAAMSLPAILALAYRLDGMDHII-----TLIIVQA 167
Cdd:cd06261    3 NTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPglglpALILALL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 168 GAGAFNIWLLKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEFVFASALLkSPESLTLAV 247
Cdd:cd06261   83 LIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLG-GGEAPGPGT 161

                        170       180
                 ....*....|....*....|....*....
gi 499320392 248 GMQQFITNNFSANWTQYSAAAIMASIPIV 276
Cdd:cd06261  162 GLLLIFAILFPGDLGVAAAVALILLLLSL 190
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
24-297 7.85e-13

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 68.26  E-value: 7.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  24 RPAERRMAWISRIFIWFMLLVVLFPVFAVVSASMAKGevftqttlipsaftLENYSKVLTETNFLIWVKNSLIICVVVSV 103
Cdd:COG1178    3 TRPRRRPRLLLLLLALLLALLVLLPLLALLLRAFTDG--------------LANFWALLSDPYLWRALGNTLLLALLVTL 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 104 IQLLLTVPMAFAFSRLKFWGRKnglmmlLLLQMFPAAMSLPA-ILALAYR--LDGMDHIITLIIVQAGAGAFNIW----- 175
Cdd:COG1178   69 LSLLLGVPLAWLLARTDFPGRR------LLRWLLLLPLALPPyVVALAWIalFGPNGLLNTLLRALFGLEPPDIYglggi 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 176 --------------LLKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEfvFASALLKSPE 241
Cdd:COG1178  143 ilvlvlfnypyvylLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLAD--FGTPLVLGGG 220

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 499320392 242 SLTLAVGMQQFITNNFSanwtqYSAAAIMASI--PIVAFATIAQKYMAKGLTAGSVKG 297
Cdd:COG1178  221 YTTLTTAIYQAWLGDFD-----LGAAAALALVllLLVLLLLLLERRLRRRRRYATVGG 273
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 32-230 1.74e-09

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 57.45  E-value: 1.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  32 WISRIFIWFMLLVVLFPVFAVVsasmakgevftqttLIPSAFTLENYSKVLTETNFLIWVKNSLIICVVVSVIQLLLTVP 111
Cdd:COG0555   11 LTLGLTLLYLSLIVLLPLAALV--------------LKAAGLGWAEFWAVLTSPRVLAALKLSLGTALIAALINLVFGLP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 112 MAFAFSRLKFWGRKnglmmllllqMFPAAMSLPaiLALAYRLDGmdhiITLIIVQAGAGAFNIWL--------------- 176
Cdd:COG0555   77 LAWVLVRYRFPGKR----------LVDALVDLP--FALPTAVAG----IALLLLFGPNGWLGQLLaplgikvaftplgiv 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499320392 177 --------------LKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEF 230
Cdd:COG0555  141 laqtfvslpfvvrtVQPVLEELDPELEEAAATLGASRWQTFRRVILPLLLPALLTGFALAFARALGEF 208
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 146-290 3.82e-08

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 52.30  E-value: 3.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  146 ILALAYRLDGMDHIITLIIVQA--GAGAFNIWLLKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTF 223
Cdd:pfam00528  38 LLVVIAILSILGHGILPAIILAllGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAF 117

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499320392  224 IGAYSEFVFASALLKSPeslTLAVGMQQFITNNFSANWTQYSAAAIMASIPIVAFATIAQKYMAKGL 290
Cdd:pfam00528 118 GGALGGAVLLEFLGSWP---GLGLLLIEAILGYDYPEIQGPVLAAALILLLLNLLVDILQRLLDPRV 181
malF PRK10999
maltose ABC transporter permease MalF;
162-223 1.25e-03

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 40.33  E-value: 1.25e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499320392 162 LIIVqagagafNIWL--------LKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNML--LVIFLFTF 223
Cdd:PRK10999 378 ILIV-------NTWLgypymmilCMGLLKAIPDDLYEASAMDGAGPFQNFFKITLPLLIKPLtpLMIASFAF 442
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 36-230 1.47e-03

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 40.05  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392   36 IFIWFMLLVVLFPVFAVVSASMAKGEvftqttliPSAFTLENYSKVLTETNFLIWVKNSLIICVVVSVIqlllTVPMAFA 115
Cdd:TIGR03262   9 GMILALLLFLLLPLLALLTKSVYDSD--------GDFIGLANFAEYFATPGLLQSLGNSLTVSAIVTAI----VVPLAFA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  116 F------SRLKFwgrKNGLMMLLLLQMFPAAMsLPAIlALAYRLDGMDhiitliIVQAGAGAFNIW-------------- 175
Cdd:TIGR03262  77 FayaltrSRIPG---KGAFRLVALLPLLAPSL-LPAI-SLIYLFGNQG------LLKGLLGGFSIYgfwgivigevfytf 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  176 -----LLKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEF 230
Cdd:TIGR03262 146 phalmILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTLVITDF 205
cysT CHL00187
sulfate transport protein; Provisional
 32-230 1.70e-03

sulfate transport protein; Provisional


Pssm-ID: 214388 [Multi-domain]  Cd Length: 237  Bit Score: 39.23  E-value: 1.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392  32 WISRIFIWFMLLVVLFPVFAVVS-ASMAKGEVFTQTTLIPSAftLENYSkvLTetnfliwVKNSLIICVVVSVIQLLltv 110
Cdd:CHL00187  12 SIYIISLSYIIFLLVLPILALLIkASQQPWSDFLQKATEPIA--LSAYS--LT-------LSMALIAALINGFFGLL--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 111 pMAFAFSRLKFWGRKnglmmllllqMFPAAMSLP---------AILALAYRLDG-MDHIITLIIVQAGAGAFNIWL---- 176
Cdd:CHL00187  78 -IAWVLVRYNFPGKR----------LLDAAVDLPfalptsvagLTLATVYGDNGwIGHLLSHLGIQIVFTKLGVLLamif 146

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499320392 177 ---------LKGAIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEF 230
Cdd:CHL00187 147 vsfpfvvrtIQPVLQEIEKELEEAAWSLGASPWQTFWKVIFPPLIPALLTGLALTFSRAIGEY 209
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 180-221 4.43e-03

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 38.15  E-value: 4.43e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 499320392 180 AIDGIPKELTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLF 221
Cdd:COG4209  199 AITGIDPELYEAAAIDGAGRWQQIWHITLPGIRPTIVILLIL 240
PRK10683 PRK10683
putrescine transporter subunit: membrane component of ABC superfamily; Provisional
 188-286 9.15e-03

putrescine transporter subunit: membrane component of ABC superfamily; Provisional


Pssm-ID: 182646  Cd Length: 317  Bit Score: 37.00  E-value: 9.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499320392 188 LTEAAYVDGASTFQTFTMIILPLLRNMLLVIFLFTFIGAYSEFVFASaLLKSPESLTLA-VGMQQFITNNfsaNWTQYSA 266
Cdd:PRK10683 214 LVEAALDLGARPLKTFFSVIVPLTKGGIIAGSMLVFIPAVGEFVIPE-LLGGPDSIMIGrVLWQEFFNNR---DWPVASA 289

                         90       100
                 ....*....|....*....|....
gi 499320392 267 AAI----MASIPIVAFATIAQKYM 286
Cdd:PRK10683 290 VAIimllLLIVPIMWFHKHQQKSV 313
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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