NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|499261028|ref|WP_010958568|]
View 

peptide chain release factor N(5)-glutamine methyltransferase [Coxiella burnetii]

Protein Classification

HemK/PrmC family methyltransferase( domain architecture ID 11483836)

HemK/PrmC family methyltransferase is a class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; such as peptide chain release factor N(5)-glutamine methyltransferase that methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0003676|GO:0032259|GO:1904047
PubMed:  12741815|12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 1-276 3.08e-128

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


:

Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 365.25  E-value: 3.08e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028   1 MLSIKEATKNISQQLttvsKTPRLDAELLLECVLKKSRADLFAYPEIQLNSSQQKTLSAYVKRRLKGEPIAYILGQKEFW 80
Cdd:PRK09328   1 MMTIAEALREATARL----ASPRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFW 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  81 SLNLKVTPDVLIPRPETEMLVEWILKNLPKDEKLRIADLGTGSGAVALAIAVERPHWTIDATDNSQAALKIAEINAKQHE 160
Cdd:PRK09328  77 GLDFKVSPGVLIPRPETEELVEWALEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 161 IKNCNFYHGEWCQALPRRDYHAIVGNPPYIPDKDQHLQQ---LKHEPREALAAGSDGLSAIKIIIHEAKSYLVNGGWLLL 237
Cdd:PRK09328 157 GARVEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQpevRDHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWLLL 236

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 499261028 238 EHGYDQAEKIMTLMQADGYREITDRRDLAGLSRMMVARR 276
Cdd:PRK09328 237 EIGYDQGEAVRALLAAAGFADVETRKDLAGRDRVVLGRR 275
 
Name Accession Description Interval E-value
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 1-276 3.08e-128

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 365.25  E-value: 3.08e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028   1 MLSIKEATKNISQQLttvsKTPRLDAELLLECVLKKSRADLFAYPEIQLNSSQQKTLSAYVKRRLKGEPIAYILGQKEFW 80
Cdd:PRK09328   1 MMTIAEALREATARL----ASPRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFW 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  81 SLNLKVTPDVLIPRPETEMLVEWILKNLPKDEKLRIADLGTGSGAVALAIAVERPHWTIDATDNSQAALKIAEINAKQHE 160
Cdd:PRK09328  77 GLDFKVSPGVLIPRPETEELVEWALEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 161 IKNCNFYHGEWCQALPRRDYHAIVGNPPYIPDKDQHLQQ---LKHEPREALAAGSDGLSAIKIIIHEAKSYLVNGGWLLL 237
Cdd:PRK09328 157 GARVEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQpevRDHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWLLL 236

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 499261028 238 EHGYDQAEKIMTLMQADGYREITDRRDLAGLSRMMVARR 276
Cdd:PRK09328 237 EIGYDQGEAVRALLAAAGFADVETRKDLAGRDRVVLGRR 275
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 3-276 2.94e-125

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 357.92  E-value: 2.94e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028   3 SIKEATKNISQQLTTV-SKTPRLDAELLLECVLKKSRADLFAYPEIQLNSSQQKTLSAYVKRRLKGEPIAYILGQKEFWS 81
Cdd:COG2890    2 TIRELLRWAAARLAAAgVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRAAGEPLAYILGEAEFYG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  82 LNLKVTPDVLIPRPETEMLVEWILKNLPKDEKLRIADLGTGSGAVALAIAVERPHWTIDATDNSQAALKIAEINAKQHEI 161
Cdd:COG2890   82 LEFKVDPGVLIPRPETEELVELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLGL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 162 KN-CNFYHGEWCQALP-RRDYHAIVGNPPYIPDKDQHLQQ---LKHEPREALAAGSDGLSAIKIIIHEAKSYLVNGGWLL 236
Cdd:COG2890  162 EDrVRFLQGDLFEPLPgDGRFDLIVSNPPYIPEDEIALLPpevRDHEPRLALDGGEDGLDFYRRIIAQAPRLLKPGGWLL 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 499261028 237 LEHGYDQAEKIMTLMQADGYREITDRRDLAGLSRMMVARR 276
Cdd:COG2890  242 LEIGEDQGEAVRALLEAAGFADVETHKDLAGRDRVVVARR 281
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 25-273 2.47e-122

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 349.08  E-value: 2.47e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028   25 DAELLLECVLKKSRADLFAYPEIQLNSSQQKTLSAYVKRRLKGEPIAYILGQKEFWSLNLKVTPDVLIPRPETEMLVEWI 104
Cdd:TIGR03534   1 DAELLLAHVLGKDRAQLLLHPEDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  105 LKNLPKDEklRIADLGTGSGAVALAIAVERPHWTIDATDNSQAALKIAEINAKQHEIKNCNFYHGEWCQALPRRDYHAIV 184
Cdd:TIGR03534  81 LERLKKGP--RVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGLENVEFLQGDWFEPLPSGKFDLIV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  185 GNPPYIPDKDQHLQQ---LKHEPREALAAGSDGLSAIKIIIHEAKSYLVNGGWLLLEHGYDQAEKIMTLMQADGYREITD 261
Cdd:TIGR03534 159 SNPPYIPEADIHLLDpevRDFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAAGFADVET 238

                         250
                  ....*....|..
gi 499261028  262 RRDLAGLSRMMV 273
Cdd:TIGR03534 239 RKDLAGKDRVVL 250
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 105-237 2.24e-19

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 82.64  E-value: 2.24e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  105 LKNLPKDEKLRIADLGTGSGAVALAIAVERPHWTIDATDNSQAALKIAEINAKQHEIKNCNFYHGEWCQALPRRDYHAIV 184
Cdd:pfam05175  24 LEHLPKDLSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLENGEVVASDVYSGVEDGKFDLII 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 499261028  185 GNPPYipdkdqhlqqlkHEPREalaagsDGLSAIKIIIHEAKSYLVNGGWLLL 237
Cdd:pfam05175 104 SNPPF------------HAGLA------TTYNVAQRFIADAKRHLRPGGELWI 138
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 115-238 1.25e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.14  E-value: 1.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 115 RIADLGTGSGAVALAIAvERPHWTIDATDNSQAALKIAEINAKQHEIKNCNFYHGEWCQALPRRD--YHAIVGNPPYipd 192
Cdd:cd02440    1 RVLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADesFDVIISDPPL--- 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 499261028 193 kdQHLQQLKHEprealaagsdglsaikiIIHEAKSYLVNGGWLLLE 238
Cdd:cd02440   77 --HHLVEDLAR-----------------FLEEARRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 1-276 3.08e-128

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 365.25  E-value: 3.08e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028   1 MLSIKEATKNISQQLttvsKTPRLDAELLLECVLKKSRADLFAYPEIQLNSSQQKTLSAYVKRRLKGEPIAYILGQKEFW 80
Cdd:PRK09328   1 MMTIAEALREATARL----ASPRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFW 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  81 SLNLKVTPDVLIPRPETEMLVEWILKNLPKDEKLRIADLGTGSGAVALAIAVERPHWTIDATDNSQAALKIAEINAKQHE 160
Cdd:PRK09328  77 GLDFKVSPGVLIPRPETEELVEWALEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 161 IKNCNFYHGEWCQALPRRDYHAIVGNPPYIPDKDQHLQQ---LKHEPREALAAGSDGLSAIKIIIHEAKSYLVNGGWLLL 237
Cdd:PRK09328 157 GARVEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQpevRDHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWLLL 236

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 499261028 238 EHGYDQAEKIMTLMQADGYREITDRRDLAGLSRMMVARR 276
Cdd:PRK09328 237 EIGYDQGEAVRALLAAAGFADVETRKDLAGRDRVVLGRR 275
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 3-276 2.94e-125

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 357.92  E-value: 2.94e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028   3 SIKEATKNISQQLTTV-SKTPRLDAELLLECVLKKSRADLFAYPEIQLNSSQQKTLSAYVKRRLKGEPIAYILGQKEFWS 81
Cdd:COG2890    2 TIRELLRWAAARLAAAgVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRAAGEPLAYILGEAEFYG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  82 LNLKVTPDVLIPRPETEMLVEWILKNLPKDEKLRIADLGTGSGAVALAIAVERPHWTIDATDNSQAALKIAEINAKQHEI 161
Cdd:COG2890   82 LEFKVDPGVLIPRPETEELVELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLGL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 162 KN-CNFYHGEWCQALP-RRDYHAIVGNPPYIPDKDQHLQQ---LKHEPREALAAGSDGLSAIKIIIHEAKSYLVNGGWLL 236
Cdd:COG2890  162 EDrVRFLQGDLFEPLPgDGRFDLIVSNPPYIPEDEIALLPpevRDHEPRLALDGGEDGLDFYRRIIAQAPRLLKPGGWLL 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 499261028 237 LEHGYDQAEKIMTLMQADGYREITDRRDLAGLSRMMVARR 276
Cdd:COG2890  242 LEIGEDQGEAVRALLEAAGFADVETHKDLAGRDRVVVARR 281
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 25-273 2.47e-122

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 349.08  E-value: 2.47e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028   25 DAELLLECVLKKSRADLFAYPEIQLNSSQQKTLSAYVKRRLKGEPIAYILGQKEFWSLNLKVTPDVLIPRPETEMLVEWI 104
Cdd:TIGR03534   1 DAELLLAHVLGKDRAQLLLHPEDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  105 LKNLPKDEklRIADLGTGSGAVALAIAVERPHWTIDATDNSQAALKIAEINAKQHEIKNCNFYHGEWCQALPRRDYHAIV 184
Cdd:TIGR03534  81 LERLKKGP--RVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGLENVEFLQGDWFEPLPSGKFDLIV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  185 GNPPYIPDKDQHLQQ---LKHEPREALAAGSDGLSAIKIIIHEAKSYLVNGGWLLLEHGYDQAEKIMTLMQADGYREITD 261
Cdd:TIGR03534 159 SNPPYIPEADIHLLDpevRDFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAAGFADVET 238

                         250
                  ....*....|..
gi 499261028  262 RRDLAGLSRMMV 273
Cdd:TIGR03534 239 RKDLAGKDRVVL 250
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 3-276 2.41e-78

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 238.79  E-value: 2.41e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028    3 SIKEATKNISQQLT--TVSKTPRLDAELLLECVLKKSRADLFAYPEIQLNSSQQKTLSAYVKRRLKGEPIAYILGQKEFW 80
Cdd:TIGR00536   2 TIQEFLRWASSALSraIARENPWLEALLLLEHDLGRERDLLLAFLTEELTPDEKERIFRLVLRRVKGVPVAYLLGSKEFY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028   81 SLNLKVTPDVLIPRPETEMLVEWILKNL-PKDEKLRIADLGTGSGAVALAIAVERPHWTIDATDNSQAALKIAEINAKQH 159
Cdd:TIGR00536  82 GLEFFVNEHVLIPRPETEELVEKALASLiSQPPILHILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAEENAEKN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  160 EIKNC-NFYHGEWCQALPRRDYHAIVGNPPYIPDKDQHLQQ--LKHEPREALAAGSDGLSAIKIIIHEAKSYLVNGGWLL 236
Cdd:TIGR00536 162 QLEHRvEFIQSNLFEPLAGQKIDIIVSNPPYIDEEDLADLPnvVRFEPLLALVGGDDGLNILRQIIELAPDYLKPNGFLV 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 499261028  237 LEHGYDQA-EKIMTLMQADGYREITDRRDLAGLSRMMVARR 276
Cdd:TIGR00536 242 CEIGNWQQkSLKELLRIKFTWYDVENGRDLNGKERVVLGFY 282
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 18-275 1.25e-55

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 184.90  E-value: 1.25e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  18 VSKTPRLDAELLLECVLKKSRADLFAYPEIQLNSSQQKTLSAYVKRRLKGEPIAYILGQKEFWSLNLKVTPDVLIPRPET 97
Cdd:PRK14966 159 LSKLPKNEARMLLQYASEYTRVQLLTRGGEEMPDEVRQRADRLAQRRLNGEPVAYILGVREFYGRRFAVNPNVLIPRPET 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  98 EMLVEWILKNLPkdEKLRIADLGTGSGAVALAIAVERPHWTIDATDNSQAALKIAEINAKQHEIKnCNFYHGEWCQA-LP 176
Cdd:PRK14966 239 EHLVEAVLARLP--ENGRVWDLGTGSGAVAVTVALERPDAFVRASDISPPALETARKNAADLGAR-VEFAHGSWFDTdMP 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 177 RR-DYHAIVGNPPYIPDKDQHLQQ--LKHEPREALAAGSDGLSAIKIIIHEAKSYLVNGGWLLLEHGYDQAEKIMTLMQA 253
Cdd:PRK14966 316 SEgKWDIIVSNPPYIENGDKHLLQgdLRFEPQIALTDFSDGLSCIRTLAQGAPDRLAEGGFLLLEHGFDQGAAVRGVLAE 395

                        250       260
                 ....*....|....*....|..
gi 499261028 254 DGYREITDRRDLAGLSRMMVAR 275
Cdd:PRK14966 396 NGFSGVETLPDLAGLDRVTLGK 417
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 3-272 8.44e-48

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 166.19  E-value: 8.44e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028   3 SIKEATKNISQQLTTVS-KTPRLDAELLLECVLKKSRADLFAYPEIQLNSSQQKTLSAYVKRRLKGEPIAYILGQKEFWS 81
Cdd:PRK01544   4 SIKQILSDATDKLNKIGiSSPQLEARILLQHVINKPIEYLLINLDEQLNEAEIEAFEKLLERRLKHEPIAYITGVKEFYS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  82 LNLKVTPDVLIPRPETEMLVEWIL------------KNLPK------------DEKLRIADLGTGSGAVALAIAVERPHW 137
Cdd:PRK01544  84 REFIVNKHVLIPRSDTEVLVDVVFqchsresgnpekKQLNPcfrgndissncnDKFLNILELGTGSGCIAISLLCELPNA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 138 TIDATDNSQAALKIAEINAKQHEIKN-CNFYHGEWCQALPRRDYHAIVGNPPYIPDKDQ---HLQQLKHEPREALAAGSD 213
Cdd:PRK01544 164 NVIATDISLDAIEVAKSNAIKYEVTDrIQIIHSNWFENIEKQKFDFIVSNPPYISHSEKsemAIETINYEPSIALFAEED 243

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 499261028 214 GLSAIKIIIHEAKSYLVNGGWLLLEHGYDQAEKIMTLMQADGYREITDRRDLAGLSRMM 272
Cdd:PRK01544 244 GLQAYFIIAENAKQFLKPNGKIILEIGFKQEEAVTQIFLDHGYNIESVYKDLQGHSRVI 302
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 48-240 4.87e-38

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 134.95  E-value: 4.87e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028   48 QLNSSQQKTLSAYVKRRLKGE-PIAYILGQKEFWSLNLKVTPDVLIPR-PETEMLVE----WILKNLPKdeklRIADLGT 121
Cdd:TIGR03533  55 RLTPSEKERILELIERRIEERiPVAYLTNEAWFAGLEFYVDERVLIPRsPIAELIEDgfapWLEPEPVK----RILDLCT 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  122 GSGAVALAIAVERPHWTIDATDNSQAALKIAEINAKQHEIKN-CNFYHGEWCQALPRRDYHAIVGNPPYIPDKD-QHL-Q 198
Cdd:TIGR03533 131 GSGCIAIACAYAFPEAEVDAVDISPDALAVAEINIERHGLEDrVTLIQSDLFAALPGRKYDLIVSNPPYVDAEDmADLpA 210

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 499261028  199 QLKHEPREALAAGSDGLSAIKIIIHEAKSYLVNGGWLLLEHG 240
Cdd:TIGR03533 211 EYHHEPELALASGEDGLDLVRRILAEAADHLNENGVLVVEVG 252
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 97-237 1.98e-21

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 88.71  E-value: 1.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  97 TEMLvewiLKNLPKDEKLRIADLGTGSGAVALAIAVERPHWTIDATDNSQAALKIAEINAKQHEIKNCNFYHGEWCQALP 176
Cdd:COG2813   38 TRLL----LEHLPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLENVEVLWSDGLSGVP 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499261028 177 RRDYHAIVGNPPYipdkdqHlQQLKHEPREALAagsdglsaikiIIHEAKSYLVNGGWLLL 237
Cdd:COG2813  114 DGSFDLILSNPPF------H-AGRAVDKEVAHA-----------LIADAARHLRPGGELWL 156
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 105-237 2.24e-19

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 82.64  E-value: 2.24e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  105 LKNLPKDEKLRIADLGTGSGAVALAIAVERPHWTIDATDNSQAALKIAEINAKQHEIKNCNFYHGEWCQALPRRDYHAIV 184
Cdd:pfam05175  24 LEHLPKDLSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLENGEVVASDVYSGVEDGKFDLII 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 499261028  185 GNPPYipdkdqhlqqlkHEPREalaagsDGLSAIKIIIHEAKSYLVNGGWLLL 237
Cdd:pfam05175 104 SNPPF------------HAGLA------TTYNVAQRFIADAKRHLRPGGELWI 138
PrmC_N pfam17827
PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the ...
 6-75 7.03e-18

PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors.


Pssm-ID: 436073 [Multi-domain]  Cd Length: 71  Bit Score: 75.98  E-value: 7.03e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499261028    6 EATKNISQQLTTV-SKTPRLDAELLLECVLKKSRADLFAYPEIQLNSSQQKTLSAYVKRRLKGEPIAYILG 75
Cdd:pfam17827   1 EALRWASSRLKEAgIESPRLDAELLLAHVLGLDRTDLLLHPEEELSEEELERFEELLERRAAGEPLQYILG 71
PRK14967 PRK14967
putative methyltransferase; Provisional
 84-277 1.57e-14

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 70.85  E-value: 1.57e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  84 LKVTPDVLIPRPETEMLVEwILKNLPKDEKLRIADLGTGSGAVALAIAVERPHWtIDATDNSQAALKIAEINA--KQHEI 161
Cdd:PRK14967   9 LLRAPGVYRPQEDTQLLAD-ALAAEGLGPGRRVLDLCTGSGALAVAAAAAGAGS-VTAVDISRRAVRSARLNAllAGVDV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 162 KncnFYHGEWCQALPRRDYHAIVGNPPYIPDKDQHLQqlKHEPREALAAGSDGLSAIKIIIHEAKSYLVNGGWLLLEH-G 240
Cdd:PRK14967  87 D---VRRGDWARAVEFRPFDVVVSNPPYVPAPPDAPP--SRGPARAWDAGPDGRAVLDRLCDAAPALLAPGGSLLLVQsE 161

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 499261028 241 YDQAEKIMTLMQADGYR-EITDRRDLaGLSRMMVARRG 277
Cdd:PRK14967 162 LSGVERTLTRLSEAGLDaEVVASQWI-PFGPVLRARAA 198
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 115-255 2.93e-13

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 67.48  E-value: 2.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 115 RIADLGTGSGAVALAIAVERPHWTIDATDNSQAALKIAEINAKQHEIKN-CNFYHG---EWCQALPRRDYHAIVGNPPYI 190
Cdd:COG4123   40 RVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGdlkEFAAELPPGSFDLVVSNPPYF 119

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499261028 191 PD------KDQHLQQLKHEPREALAAgsdglsaikiIIHEAKSYLVNGGWLLLEHGYDQAEKIMTLMQADG 255
Cdd:COG4123  120 KAgsgrksPDEARAIARHEDALTLED----------LIRAAARLLKPGGRFALIHPAERLAEILAALRKYG 180
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 115-238 1.25e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.14  E-value: 1.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 115 RIADLGTGSGAVALAIAvERPHWTIDATDNSQAALKIAEINAKQHEIKNCNFYHGEWCQALPRRD--YHAIVGNPPYipd 192
Cdd:cd02440    1 RVLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADesFDVIISDPPL--- 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 499261028 193 kdQHLQQLKHEprealaagsdglsaikiIIHEAKSYLVNGGWLLLE 238
Cdd:cd02440   77 --HHLVEDLAR-----------------FLEEARRLLKPGGVLVLT 103
PRK14968 PRK14968
putative methyltransferase; Provisional
 88-263 1.73e-09

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 56.06  E-value: 1.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  88 PDVLIPRPETEMLVEwilkNLPKDEKLRIADLGTGSGAVALAIAvERPHWTIdATDNSQAALKIAEINAKQHEIKNC--N 165
Cdd:PRK14968   3 DEVYEPAEDSFLLAE----NAVDKKGDRVLEVGTGSGIVAIVAA-KNGKKVV-GVDINPYAVECAKCNAKLNNIRNNgvE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 166 FYHGEWCQALPRRDYHAIVGNPPYIPDKDQhlqqlkHEPRE----ALAAGSDGLSAIKIIIHEAKSYLVNGG-WLLLEHG 240
Cdd:PRK14968  77 VIRSDLFEPFRGDKFDVILFNPPYLPTEEE------EEWDDwlnyALSGGKDGREVIDRFLDEVGRYLKPGGrILLLQSS 150

                        170       180
                 ....*....|....*....|....
gi 499261028 241 YDQAEKIMTLMQADGYR-EITDRR 263
Cdd:PRK14968 151 LTGEDEVLEYLEKLGFEaEVVAEE 174
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
115-211 2.24e-09

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 53.67  E-value: 2.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 115 RIADLGTGSGAVALAIAVERPHWTIDATDNSQAALKIAeinakQHEIKNCNFYHGEWCQALPRRDYHAIVGNP--PYIPD 192
Cdd:COG4106    4 RVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARA-----RARLPNVRFVVADLRDLDPPEPFDLVVSNAalHWLPD 78

                         90
                 ....*....|....*....
gi 499261028 193 KDQHLQQLkhepREALAAG 211
Cdd:COG4106   79 HAALLARL----AAALAPG 93
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 104-265 8.89e-08

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 51.01  E-value: 8.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  104 ILKNLPKDEKLRIADLGTGSGAVAlaIAVERPHWTIDATDNSQAALKIAEINAKQHEiKNCNFYHGEWCQALpRRDYHAI 183
Cdd:TIGR00537  11 LEANLRELKPDDVLEIGAGTGLVA--IRLKGKGKCILTTDINPFAVKELRENAKLNN-VGLDVVMTDLFKGV-RGKFDVI 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  184 VGNPPYIPDKDQhlqqlkhEPRE-----ALAAGSDGLSAIKIIIHEAKSYLVNGGWL-LLEHGYDQAEKIMTLMQADGYR 257
Cdd:TIGR00537  87 LFNPPYLPLEDD-------LRRGdwldvAIDGGKDGRKVIDRFLDELPEILKEGGRVqLIQSSLNGEPDTFDKLDERGFR 159


                  ....*....
gi 499261028  258 -EITDRRDL 265
Cdd:TIGR00537 160 yEIVAERGL 168
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 92-276 1.05e-07

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 51.07  E-value: 1.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  92 IPRPETEMLVEwILKNLPKDekLRIADLGTGSGAVALAIAvERPHWTIDATDNSQAALKIAEINAKQHEIKNCNFYHGEW 171
Cdd:COG0500    9 ELLPGLAALLA-LLERLPKG--GRVLDLGCGTGRNLLALA-ARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 172 CQ--ALPRRDYHAIV--GNppyipdkdqhLQQLKHEPREAlaagsdglsaikiIIHEAKSYLVNGGWLLLE-HGYDQAEK 246
Cdd:COG0500   85 AEldPLPAESFDLVVafGV----------LHHLPPEEREA-------------LLRELARALKPGGVLLLSaSDAAAALS 141

                        170       180       190
                 ....*....|....*....|....*....|
gi 499261028 247 IMTLMQADGYREITDRRDLAGLSRMMVARR 276
Cdd:COG0500  142 LARLLLLATASLLELLLLLRLLALELYLRA 171
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 102-257 2.31e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 49.22  E-value: 2.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 102 EWILKNLPKDEKLRIADLGTGSGAVALAIAveRPHWTIDATDNSQAALKIAEINAKQHEIkNCNFYHGEWcQALPRRD-- 179
Cdd:COG2226   12 EALLAALGLRPGARVLDLGCGTGRLALALA--ERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDA-EDLPFPDgs 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 180 YHAIVGNP--PYIPDKDQHLQqlkheprealaagsdglsaikiiihEAKSYLVNGGWLLL-EHGYDQAEKIMTLMQADGY 256
Cdd:COG2226   88 FDLVISSFvlHHLPDPERALA-------------------------EIARVLKPGGRLVVvDFSPPDLAELEELLAEAGF 142


                 .
gi 499261028 257 R 257
Cdd:COG2226  143 E 143
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 97-188 2.85e-07

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 50.95  E-value: 2.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  97 TEMLVEWILKNLPKDEKLRIADLGTGSGAVALAIAveRPHWTIDATDNSQAALKIAEINAKQHEIKNCNFYHGEWCQALP 176
Cdd:COG2265  218 AEALYAAALEWLDLTGGERVLDLYCGVGTFALPLA--RRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLP 295

                         90
                 ....*....|....*.
gi 499261028 177 RRDYH----AIVGNPP 188
Cdd:COG2265  296 ELLWGgrpdVVVLDPP 311
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 110-171 1.63e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 46.64  E-value: 1.63e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499261028  110 KDEKLRIADLGTGSGAVALAIAVE-RPHWTIDATDNSQAALKIAEINAKQHEIKNCNFYHGEW 171
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEElGPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDI 63
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 116-195 2.36e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 44.86  E-value: 2.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  116 IADLGTGSGAVALAIAvERPHWTIDATDNSQAALKIAEINAKQHEIkNCNFYHGEwCQALPRRD--YHAIVGNPP--YIP 191
Cdd:pfam13649   1 VLDLGCGTGRLTLALA-RRGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQGD-AEDLPFPDgsFDLVVSSGVlhHLP 77


                  ....
gi 499261028  192 DKDQ 195
Cdd:pfam13649  78 DPDL 81
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 100-211 1.42e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 43.47  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 100 LVEWILKNLPKDekLRIADLGTGSGAVALAIAveRPHWTIDATDNSQAALKIAEINAKQHEIkncNFYHGEWCQ-ALPRR 178
Cdd:COG2227   14 LAALLARLLPAG--GRVLDVGCGTGRLALALA--RRGADVTGVDISPEALEIARERAAELNV---DFVQGDLEDlPLEDG 86

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 499261028 179 DYHAIVGN--PPYIPDKDQHLQQLkhepREALAAG 211
Cdd:COG2227   87 SFDLVICSevLEHLPDPAALLREL----ARLLKPG 117
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
97-257 7.21e-05

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 43.24  E-value: 7.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  97 TEMLVEWILKNLPKDEklRIADLGTGSGavALAIAVER-PHWTIDATDNSQAALKIAEINAKQHEIKNC-NFYHGEwcqA 174
Cdd:COG2264  135 TRLCLEALEKLLKPGK--TVLDVGCGSG--ILAIAAAKlGAKRVLAVDIDPVAVEAARENAELNGVEDRiEVVLGD---L 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 175 LPRRDYHAIVGNppyIpdkdqhlqqlkhepreaLAagsdglSAIKIIIHEAKSYLVNGGWL----LLEHgydQAEKIMTL 250
Cdd:COG2264  208 LEDGPYDLVVAN---I-----------------LA------NPLIELAPDLAALLKPGGYLilsgILEE---QADEVLAA 258


                 ....*..
gi 499261028 251 MQADGYR 257
Cdd:COG2264  259 YEAAGFE 265
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
98-211 1.66e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 41.52  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  98 EMLVEWILKNLPKDEKLRIADLGTGSGAVALAIaveRPH-WTIDATDNSQAALKIAEinAKQHEIkncNFYHGEWCQ-AL 175
Cdd:COG4976   32 ALLAEELLARLPPGPFGRVLDLGCGTGLLGEAL---RPRgYRLTGVDLSEEMLAKAR--EKGVYD---RLLVADLADlAE 103

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 499261028 176 PRRDYHAIVGN--PPYIPDKDQHLQQLkhepREALAAG 211
Cdd:COG4976  104 PDGRFDLIVAAdvLTYLGDLAAVFAGV----ARALKPG 137
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
95-157 4.91e-04

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 40.52  E-value: 4.91e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499261028  95 PETEMLVEWILKNLPKDEklRIADLGTGSGavALAIAVER-PHWTIDATDNSQAALKIAEINAK 157
Cdd:PRK00517 104 PTTRLCLEALEKLVLPGK--TVLDVGCGSG--ILAIAAAKlGAKKVLAVDIDPQAVEAARENAE 163
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 100-184 5.23e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 39.53  E-value: 5.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 100 LVEWILKNLPKDEKLRIADLGTGSGAVALAIAvERPHWTIDATDNSQAALKIAEINAKQHEIKN-CNFYHGEWCQALPRR 178
Cdd:COG2230   39 KLDLILRKLGLKPGMRVLDIGCGWGGLALYLA-RRYGVRVTGVTLSPEQLEYARERAAEAGLADrVEVRLADYRDLPADG 117


                 ....*.
gi 499261028 179 DYHAIV 184
Cdd:COG2230  118 QFDAIV 123
PRK15001 PRK15001
23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;
103-189 2.15e-03

23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;


Pssm-ID: 184963 [Multi-domain]  Cd Length: 378  Bit Score: 39.24  E-value: 2.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028 103 WILKNLPKDEKLRIADLGTGSGAVALAIAVERPHWTIDATDNSQAALKIAEINAKQH---EIKNCNFYHGEWCQALPRRD 179
Cdd:PRK15001 219 FFMQHLPENLEGEIVDLGCGNGVIGLTLLDKNPQAKVVFVDESPMAVASSRLNVETNmpeALDRCEFMINNALSGVEPFR 298

                         90
                 ....*....|
gi 499261028 180 YHAIVGNPPY 189
Cdd:PRK15001 299 FNAVLCNPPF 308
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 118-211 3.31e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 36.19  E-value: 3.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499261028  118 DLGTGSGAVALAIAVERPHWTIDATDNSQAALKIAEINAKQHEIKNCNFYHGEWCQA--LPRRDYHAIVGNP--PYIPDK 193
Cdd:pfam08242   2 EIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLgeLDPGSFDVVVASNvlHHLADP 81

                          90
                  ....*....|....*...
gi 499261028  194 DQHLQQLkhepREALAAG 211
Cdd:pfam08242  82 RAVLRNI----RRLLKPG 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH