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Conserved domains on  [gi|499260913|ref|WP_010958453|]
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LuxR C-terminal-related transcriptional regulator [Coxiella burnetii]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 10006622)

helix-turn-helix (HTH) transcriptional regulator binds DNA and functions as a repressor or activator; similar to CsgD family transcriptional regulators which function in controlling the expression of structural components and assembly factors of curli fimbriae

Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  20466769

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
47-98 1.35e-12

DNA-binding transcriptional regulator, CsgD family [Transcription];


:

Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 61.31  E-value: 1.35e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499260913  47 FTNREFTIATYLLKGYRYKQIAEVLNLSSRSVEFYIQNMREKFYCRNKRALI 98
Cdd:COG2771  128 LTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELV 179
 
Name Accession Description Interval E-value
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
47-98 1.35e-12

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 61.31  E-value: 1.35e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499260913  47 FTNREFTIATYLLKGYRYKQIAEVLNLSSRSVEFYIQNMREKFYCRNKRALI 98
Cdd:COG2771  128 LTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELV 179
GerE pfam00196
Bacterial regulatory proteins, luxR family;
47-98 8.20e-12

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 56.05  E-value: 8.20e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 499260913   47 FTNREFTIATYLLKGYRYKQIAEVLNLSSRSVEFYIQNMREKFYCRNKRALI 98
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELV 54
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 47-98 6.09e-11

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 53.69  E-value: 6.09e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 499260913    47 FTNREFTIATYLLKGYRYKQIAEVLNLSSRSVEFYIQNMREKFYCRNKRALI 98
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAV 55
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 47-98 3.61e-09

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 49.07  E-value: 3.61e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499260913  47 FTNREFTIATYLLKGYRYKQIAEVLNLSSRSVEFYIQNMREKFYCRNKRALI 98
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLV 52
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
40-96 3.26e-05

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 41.38  E-value: 3.26e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 499260913  40 EPYPKVYFTNREFTIATYLLKGYRYKQIAEVLNLSSRSVEFYIQNMREKFYCRNKRA 96
Cdd:PRK10403 147 EEDPFSVLTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVA 203
 
Name Accession Description Interval E-value
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
47-98 1.35e-12

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 61.31  E-value: 1.35e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499260913  47 FTNREFTIATYLLKGYRYKQIAEVLNLSSRSVEFYIQNMREKFYCRNKRALI 98
Cdd:COG2771  128 LTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELV 179
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 47-98 2.91e-12

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 59.14  E-value: 2.91e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499260913  47 FTNREFTIATYLLKGYRYKQIAEVLNLSSRSVEFYIQNMREKFYCRNKRALI 98
Cdd:COG2197   70 LTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELV 121
GerE pfam00196
Bacterial regulatory proteins, luxR family;
47-98 8.20e-12

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 56.05  E-value: 8.20e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 499260913   47 FTNREFTIATYLLKGYRYKQIAEVLNLSSRSVEFYIQNMREKFYCRNKRALI 98
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELV 54
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 47-98 6.09e-11

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 53.69  E-value: 6.09e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 499260913    47 FTNREFTIATYLLKGYRYKQIAEVLNLSSRSVEFYIQNMREKFYCRNKRALI 98
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAV 55
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 47-98 3.61e-09

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 49.07  E-value: 3.61e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499260913  47 FTNREFTIATYLLKGYRYKQIAEVLNLSSRSVEFYIQNMREKFYCRNKRALI 98
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLV 52
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 43-98 9.49e-06

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 40.71  E-value: 9.49e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 499260913  43 PKVYFTNREFTIATYLLKGYRYKQIAEVLNLSSRSVEFYIQNMREKFYCRNKRALI 98
Cdd:COG5905    9 HPSLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAV 64
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
40-96 3.26e-05

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 41.38  E-value: 3.26e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 499260913  40 EPYPKVYFTNREFTIATYLLKGYRYKQIAEVLNLSSRSVEFYIQNMREKFYCRNKRA 96
Cdd:PRK10403 147 EEDPFSVLTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVA 203
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 48-93 4.33e-04

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 38.16  E-value: 4.33e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 499260913  48 TNREFTIATYLLKGYRYKQIAEVLNLSSRSVEFYIQNMREKFYCRN 93
Cdd:COG4566  139 TPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGARS 184
Sigma70_r4_2 pfam08281
Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 ...
 59-88 1.18e-03

Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif.


Pssm-ID: 400535 [Multi-domain]  Cd Length: 54  Bit Score: 34.74  E-value: 1.18e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 499260913   59 LKGYRYKQIAEVLNLSSRSVEFYIQNMREK 88
Cdd:pfam08281  24 LEGLSYAEIAELLGISEGTVKSRLSRARKK 53
PRK10188 PRK10188
transcriptional regulator SdiA;
43-94 1.39e-03

transcriptional regulator SdiA;


Pssm-ID: 182292 [Multi-domain]  Cd Length: 240  Bit Score: 36.69  E-value: 1.39e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499260913  43 PKVYFTNREFTIATYLLKGYRYKQIAEVLNLSSRSVEFYIQNMREKFYCRNK 94
Cdd:PRK10188 176 PEMNFSKREKEILKWTAEGKTSAEIAMILSISENTVNFHQKNMQKKFNAPNK 227
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
47-107 6.89e-03

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 34.85  E-value: 6.89e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499260913  47 FTNREFTIATYLLKGYRYKQIAEVLNLSSRSVEFYIQNMREKFYCRNKRALIGVLKNIDIL 107
Cdd:PRK09935 150 LSNREVTILRYLVSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIDYAKLHELL 210
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
47-93 8.60e-03

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 34.49  E-value: 8.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 499260913  47 FTNREFTIATYLLKGYRYKQIAEVLNLSSRSVEFYIQNMREKFYCRN 93
Cdd:PRK09958 144 LSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKS 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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