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Conserved domains on  [gi|499208436|ref|WP_010905976|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Lactococcus]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10054599)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 10-65 1.28e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


:

Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 39.46  E-value: 1.28e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 499208436  10 SRLKLLIKDAHKSFNQVERELGYPRNTLKNY-KYKKKPSVGRVFEMANYFNVSIEFL 65
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIeNGKRNPSLETLEKLAKALGVSLDEL 58
 
Name Accession Description Interval E-value
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 10-65 1.28e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 39.46  E-value: 1.28e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 499208436  10 SRLKLLIKDAHKSFNQVERELGYPRNTLKNY-KYKKKPSVGRVFEMANYFNVSIEFL 65
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIeNGKRNPSLETLEKLAKALGVSLDEL 58
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-78 3.21e-05

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 38.82  E-value: 3.21e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499208436   1 MEHEYLFVYSRLKLLIKDAHKSFNQVERELGYPRNTLKNYKY-KKKPSVGRVFEMANYFNVSIEFLLGIEEKDNKNSLA 78
Cdd:COG1396    1 MSTLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERgRRNPSLETLLKLAKALGVSLDELLGGADEELPEALL 79
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
11-65 2.55e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 33.26  E-value: 2.55e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 499208436    11 RLKLLIKDAHKSFNQVERELGYPRNTLKNY-KYKKKPSVGRVFEMANYFNVSIEFL 65
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIeNGKRKPSLETLKKLAKALGVSLDEL 56
 
Name Accession Description Interval E-value
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 10-65 1.28e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 39.46  E-value: 1.28e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 499208436  10 SRLKLLIKDAHKSFNQVERELGYPRNTLKNY-KYKKKPSVGRVFEMANYFNVSIEFL 65
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIeNGKRNPSLETLEKLAKALGVSLDEL 58
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-78 3.21e-05

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 38.82  E-value: 3.21e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499208436   1 MEHEYLFVYSRLKLLIKDAHKSFNQVERELGYPRNTLKNYKY-KKKPSVGRVFEMANYFNVSIEFLLGIEEKDNKNSLA 78
Cdd:COG1396    1 MSTLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERgRRNPSLETLLKLAKALGVSLDELLGGADEELPEALL 79
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
11-70 7.43e-04

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 34.82  E-value: 7.43e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499208436  11 RLKLLIKDAHKSFNQVERELGYPRNTLKNY-KYKKKPSVGRVFEMANYFNVSIEFLLGIEE 70
Cdd:COG1476    8 RLKELRKERGLTQEELAELLGVSRQTISAIeNGKYNPSLELALKIARALGVSLEELFSLEE 68
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
11-65 2.55e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 33.26  E-value: 2.55e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 499208436    11 RLKLLIKDAHKSFNQVERELGYPRNTLKNY-KYKKKPSVGRVFEMANYFNVSIEFL 65
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIeNGKRKPSLETLKKLAKALGVSLDEL 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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