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Conserved domains on  [gi|499202172|ref|WP_010899712|]
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ATP phosphoribosyltransferase regulatory subunit [Halalkalibacterium halodurans]

Protein Classification

ATP phosphoribosyltransferase regulatory subunit( domain architecture ID 11485747)

ATP phosphoribosyltransferase regulatory subunit is required for the first step of histidine biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
hisZ PRK12292
ATP phosphoribosyltransferase regulatory subunit; Provisional
 5-368 6.41e-167

ATP phosphoribosyltransferase regulatory subunit; Provisional


:

Pssm-ID: 237043 [Multi-domain]  Cd Length: 391  Bit Score: 472.81  E-value: 6.41e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172   5 FMFEKPFGMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETVGVVSA-ILDQQLFKLLDQQ-GNTLVLRPDM 82
Cdd:PRK12292   1 MMWQLPEGIRDLLPEEARKIEEIRRRLLDLFRRWGYEEVITPTLEYLDTLLAGGGaILDLRTFKLVDQLsGRTLGLRPDM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  83 TAPIARLVASSLKDRAYPLRLAYQSNVYRAQQNEGGKPAEFEQLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVAI 162
Cdd:PRK12292  81 TAQIARIAATRLANRPGPLRLCYAGNVFRAQERGLGRSREFLQSGVELIGDAGLEADAEVILLLLEALKALGLPNFTLDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 163 GHVGYVNALLMDVVGNEQRADRLRRFLYEKNYVGYREHVKslNLSTIDKSRLMNLLSLRGGRAAIEEARGLIQTEKGKTA 242
Cdd:PRK12292 161 GHVGLFRALLEAAGLSEELEEVLRRALANKDYVALEELVL--DLSEELRDALLALPRLRGGREVLEEARKLLPSLPIKRA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 243 LAEMTKLYEVLESYGASEYVKFDLTLVLHMSYYTGVVFEGYGNRLGVPLCSGGRYDELLSKFHRPAQATGFGVRIDLLVE 322
Cdd:PRK12292 239 LDELEALAEALEKYGYGIPLSLDLGLLRHLDYYTGIVFEGYVDGVGNPIASGGRYDDLLGRFGRARPATGFSLDLDRLLE 318

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 499202172 323 ALnGEIISNGHEQTCILFSNERRFEAIELARKKRANGEAVVLQDLA 368
Cdd:PRK12292 319 LQ-LELPVEARKDLVIAPDSEALAAALAAAQELRKKGEIVVLALPG 363
 
Name Accession Description Interval E-value
hisZ PRK12292
ATP phosphoribosyltransferase regulatory subunit; Provisional
 5-368 6.41e-167

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 237043 [Multi-domain]  Cd Length: 391  Bit Score: 472.81  E-value: 6.41e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172   5 FMFEKPFGMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETVGVVSA-ILDQQLFKLLDQQ-GNTLVLRPDM 82
Cdd:PRK12292   1 MMWQLPEGIRDLLPEEARKIEEIRRRLLDLFRRWGYEEVITPTLEYLDTLLAGGGaILDLRTFKLVDQLsGRTLGLRPDM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  83 TAPIARLVASSLKDRAYPLRLAYQSNVYRAQQNEGGKPAEFEQLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVAI 162
Cdd:PRK12292  81 TAQIARIAATRLANRPGPLRLCYAGNVFRAQERGLGRSREFLQSGVELIGDAGLEADAEVILLLLEALKALGLPNFTLDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 163 GHVGYVNALLMDVVGNEQRADRLRRFLYEKNYVGYREHVKslNLSTIDKSRLMNLLSLRGGRAAIEEARGLIQTEKGKTA 242
Cdd:PRK12292 161 GHVGLFRALLEAAGLSEELEEVLRRALANKDYVALEELVL--DLSEELRDALLALPRLRGGREVLEEARKLLPSLPIKRA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 243 LAEMTKLYEVLESYGASEYVKFDLTLVLHMSYYTGVVFEGYGNRLGVPLCSGGRYDELLSKFHRPAQATGFGVRIDLLVE 322
Cdd:PRK12292 239 LDELEALAEALEKYGYGIPLSLDLGLLRHLDYYTGIVFEGYVDGVGNPIASGGRYDDLLGRFGRARPATGFSLDLDRLLE 318

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 499202172 323 ALnGEIISNGHEQTCILFSNERRFEAIELARKKRANGEAVVLQDLA 368
Cdd:PRK12292 319 LQ-LELPVEARKDLVIAPDSEALAAALAAAQELRKKGEIVVLALPG 363
hisZ_biosyn_reg TIGR00443
ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA ...
 14-325 4.31e-139

ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA synthetase, found in Bacillus subtilis, Synechocystis sp., Aquifex aeolicus, and others, are in fact a regulatory subunit of ATP phosphoribosyltransferase, and usually encoded by a gene adjacent to that encoding the catalytic subunit. [Amino acid biosynthesis, Histidine family]


Pssm-ID: 273081 [Multi-domain]  Cd Length: 313  Bit Score: 398.91  E-value: 4.31e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172   14 RDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETVGVVSAILDQQLFKLLDQQGNTLVLRPDMTAPIARLVASS 93
Cdd:TIGR00443   1 RDLLPEEAARKEEIERQLQDVFRSWGYQEIITPTLEYLDTLSAGSGILNEDLFKLFDQLGRVLGLRPDMTAPIARLVSTR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172   94 LKDRAYPLRLAYQSNVYRAQQNEGGKPAEFEQLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVAIGHVGYVNALLM 173
Cdd:TIGR00443  81 LRDRPLPLRLCYAGNVFRTNESGGGRSREFTQAGVELIGAGGPAADAEVIALLIEALKALGLKDFKIELGHVGLVRALLE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  174 DVVGNEQRADRLRRFLYEKNYVGYREHVKSLNLSTIDKSRLMNLLSLRG-GRAAIEEARGLIQTEKGKTALAEMTKLYEV 252
Cdd:TIGR00443 161 EAGLPEEAREALREALARKDLVALEELVAELGLSPEVRERLLALPRLRGdGEEVLEEARALAGSETAEAALDELEAVLEL 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499202172  253 LESYGASEYVKFDLTLVLHMSYYTGVVFEGYGNRLGVPLCSGGRYDELLSKFHRPAQATGFGVRIDLLVEALN 325
Cdd:TIGR00443 241 LEARGVEEYISLDLGLVRGYHYYTGLIFEGYAPGLGAPLAGGGRYDELLGRFGRPLPATGFALNLERLLEALT 313
HisZ COG3705
ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];
17-327 1.04e-131

ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];


Pssm-ID: 442919 [Multi-domain]  Cd Length: 312  Bit Score: 380.29  E-value: 1.04e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  17 LPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETV-GVVSAILDQQLFKLLDQQGNTLVLRPDMTAPIARLVASSLK 95
Cdd:COG3705    1 LPEEAARKEELRRRLLDVFRSWGYELVEPPLLEYLDSLlTGSGADLDLQTFKLVDQLGRTLGLRPDMTPQVARIAATRLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  96 DRAYPLRLAYQSNVYRAQQNEGGKPAEFEQLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVAIGHVGYVNALLMDV 175
Cdd:COG3705   81 NRPGPLRLCYAGNVFRTRPSGLGRSREFLQAGAELIGHAGLEADAEVIALALEALKAAGLEDFTLDLGHVGLFRALLEAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 176 VGNEQRADRLRRFLYEKNYVGYREHVKSLNLSTIDKSRLMNLLSLRGGRAAIEEARGLIQTEKGKTALAEMTKLYEVLES 255
Cdd:COG3705  161 GLSEEQREELRRALARKDAVELEELLAELGLSEELAEALLALPELYGGEEVLARARALLLDAAIRAALDELEALAEALAA 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499202172 256 YGASEYVKFDLTLVLHMSYYTGVVFEGYGNRLGVPLCSGGRYDELLSKFHRPAQATGFGVRIDLLVEALNGE 327
Cdd:COG3705  241 RGPDVRLTFDLSELRGYDYYTGIVFEAYAPGVGDPLARGGRYDGLLAAFGRARPATGFSLDLDRLLRALPAA 312
tRNA-synt_His pfam13393
Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP ...
 12-320 2.68e-77

Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP phosphoribosyltransferase regulatory subunits.


Pssm-ID: 433170 [Multi-domain]  Cd Length: 309  Bit Score: 241.34  E-value: 2.68e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172   12 GMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETVGVVSAILDQQLFKLLDQQGNTLVLRPDMTAPIARLVA 91
Cdd:pfam13393   1 GIRDLLPPEARRIEELRRRLLDLFRSWGYELVMPPLLEYLDSLLTGTGADLDQTFKLVDQSGRLLGLRADITPQVARIDA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172   92 SSLKdRAYPLRLAYQSNVYRAQQNEGGKPAEFEQLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVAIGHVGYVNAL 171
Cdd:pfam13393  81 HRLN-RPGPLRLCYAGSVLRTRPKGLGRSREPLQVGAELIGHAGIEADAEIISLLLEALAAAGVPGVTLDLGHVGLVRAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  172 LMDVVGNEQRADRLRRFLYEKNYVGYREHVKSLNLSTIDKSRLMNLLSLRGGRAAIEEARGLI-QTEKGKTALAEMTKLY 250
Cdd:pfam13393 160 LEAAGLSEALEEALRAALQRKDAAELAELAAEAGLPPALRRALLALPDLYGGPEVLDEARAALpGLPALQEALDELEALA 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  251 EVLESYGASEYVKFDLTLVLHMSYYTGVVFEGYGNRLGVPLCSGGRYDELLSKFHRPAQATGFGVRIDLL 320
Cdd:pfam13393 240 ALLEALGDGVRLTFDLAELRGYEYYTGIVFAAYAPGVGEPLARGGRYDDLGAAFGRARPATGFSLDLEAL 309
HisRS-like_core cd00773
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. ...
 21-324 5.77e-70

Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. This domain is also found at the C-terminus of eukaryotic GCN2 protein kinase and at the N-terminus of the ATP phosphoribosyltransferase accessory subunit, HisZ. HisZ along with HisG catalyze the first reaction in histidine biosynthesis. HisZ is found only in a subset of bacteria and differs from HisRS in lacking a C-terminal anti-codon binding domain.


Pssm-ID: 238396 [Multi-domain]  Cd Length: 261  Bit Score: 220.94  E-value: 5.77e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  21 YKTKKNICDQMTEEINLWGYDMIETPTLEYYET-VGVVSAILDQQLFKLLDQQGNTLVLRPDMTAPIARLVASSLKDRAY 99
Cdd:cd00773    2 AALRRYIEDTLREVFERYGYEEIDTPVFEYTELfLRKSGDEVSKEMYRFKDKGGRDLALRPDLTAPVARAVAENLLSLPL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 100 PLRLAYQSNVYRAQQNEGGKPAEFEQLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVAIGHVGYVNALLMDVVGNE 179
Cdd:cd00773   82 PLKLYYIGPVFRYERPQKGRYREFYQVGVEIIGSDSPLADAEVIALAVEILEALGLKDFQIKINHRGILDGIAGLLEDRE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 180 QRADRLRRFLyeknyvgyrehvkslnlstidksrlmnllslrggraaieeargliqtekGKTALAEMTKLYEVLESYGAS 259
Cdd:cd00773  162 EYIERLIDKL-------------------------------------------------DKEALAHLEKLLDYLEALGVD 192

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499202172 260 EYVKFDLTLVLHMSYYTGVVFEGYGNRLGV--PLCSGGRYDELLS-KFHRPAQATGFGVRIDLLVEAL 324
Cdd:cd00773  193 IKYSIDLSLVRGLDYYTGIVFEAVADGLGAqgSIAGGGRYDGLLEeFGGEDVPAVGFAIGLERLLLAL 260
 
Name Accession Description Interval E-value
hisZ PRK12292
ATP phosphoribosyltransferase regulatory subunit; Provisional
 5-368 6.41e-167

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 237043 [Multi-domain]  Cd Length: 391  Bit Score: 472.81  E-value: 6.41e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172   5 FMFEKPFGMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETVGVVSA-ILDQQLFKLLDQQ-GNTLVLRPDM 82
Cdd:PRK12292   1 MMWQLPEGIRDLLPEEARKIEEIRRRLLDLFRRWGYEEVITPTLEYLDTLLAGGGaILDLRTFKLVDQLsGRTLGLRPDM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  83 TAPIARLVASSLKDRAYPLRLAYQSNVYRAQQNEGGKPAEFEQLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVAI 162
Cdd:PRK12292  81 TAQIARIAATRLANRPGPLRLCYAGNVFRAQERGLGRSREFLQSGVELIGDAGLEADAEVILLLLEALKALGLPNFTLDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 163 GHVGYVNALLMDVVGNEQRADRLRRFLYEKNYVGYREHVKslNLSTIDKSRLMNLLSLRGGRAAIEEARGLIQTEKGKTA 242
Cdd:PRK12292 161 GHVGLFRALLEAAGLSEELEEVLRRALANKDYVALEELVL--DLSEELRDALLALPRLRGGREVLEEARKLLPSLPIKRA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 243 LAEMTKLYEVLESYGASEYVKFDLTLVLHMSYYTGVVFEGYGNRLGVPLCSGGRYDELLSKFHRPAQATGFGVRIDLLVE 322
Cdd:PRK12292 239 LDELEALAEALEKYGYGIPLSLDLGLLRHLDYYTGIVFEGYVDGVGNPIASGGRYDDLLGRFGRARPATGFSLDLDRLLE 318

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 499202172 323 ALnGEIISNGHEQTCILFSNERRFEAIELARKKRANGEAVVLQDLA 368
Cdd:PRK12292 319 LQ-LELPVEARKDLVIAPDSEALAAALAAAQELRKKGEIVVLALPG 363
hisZ_biosyn_reg TIGR00443
ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA ...
 14-325 4.31e-139

ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA synthetase, found in Bacillus subtilis, Synechocystis sp., Aquifex aeolicus, and others, are in fact a regulatory subunit of ATP phosphoribosyltransferase, and usually encoded by a gene adjacent to that encoding the catalytic subunit. [Amino acid biosynthesis, Histidine family]


Pssm-ID: 273081 [Multi-domain]  Cd Length: 313  Bit Score: 398.91  E-value: 4.31e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172   14 RDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETVGVVSAILDQQLFKLLDQQGNTLVLRPDMTAPIARLVASS 93
Cdd:TIGR00443   1 RDLLPEEAARKEEIERQLQDVFRSWGYQEIITPTLEYLDTLSAGSGILNEDLFKLFDQLGRVLGLRPDMTAPIARLVSTR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172   94 LKDRAYPLRLAYQSNVYRAQQNEGGKPAEFEQLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVAIGHVGYVNALLM 173
Cdd:TIGR00443  81 LRDRPLPLRLCYAGNVFRTNESGGGRSREFTQAGVELIGAGGPAADAEVIALLIEALKALGLKDFKIELGHVGLVRALLE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  174 DVVGNEQRADRLRRFLYEKNYVGYREHVKSLNLSTIDKSRLMNLLSLRG-GRAAIEEARGLIQTEKGKTALAEMTKLYEV 252
Cdd:TIGR00443 161 EAGLPEEAREALREALARKDLVALEELVAELGLSPEVRERLLALPRLRGdGEEVLEEARALAGSETAEAALDELEAVLEL 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499202172  253 LESYGASEYVKFDLTLVLHMSYYTGVVFEGYGNRLGVPLCSGGRYDELLSKFHRPAQATGFGVRIDLLVEALN 325
Cdd:TIGR00443 241 LEARGVEEYISLDLGLVRGYHYYTGLIFEGYAPGLGAPLAGGGRYDELLGRFGRPLPATGFALNLERLLEALT 313
HisZ COG3705
ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];
17-327 1.04e-131

ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];


Pssm-ID: 442919 [Multi-domain]  Cd Length: 312  Bit Score: 380.29  E-value: 1.04e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  17 LPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETV-GVVSAILDQQLFKLLDQQGNTLVLRPDMTAPIARLVASSLK 95
Cdd:COG3705    1 LPEEAARKEELRRRLLDVFRSWGYELVEPPLLEYLDSLlTGSGADLDLQTFKLVDQLGRTLGLRPDMTPQVARIAATRLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  96 DRAYPLRLAYQSNVYRAQQNEGGKPAEFEQLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVAIGHVGYVNALLMDV 175
Cdd:COG3705   81 NRPGPLRLCYAGNVFRTRPSGLGRSREFLQAGAELIGHAGLEADAEVIALALEALKAAGLEDFTLDLGHVGLFRALLEAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 176 VGNEQRADRLRRFLYEKNYVGYREHVKSLNLSTIDKSRLMNLLSLRGGRAAIEEARGLIQTEKGKTALAEMTKLYEVLES 255
Cdd:COG3705  161 GLSEEQREELRRALARKDAVELEELLAELGLSEELAEALLALPELYGGEEVLARARALLLDAAIRAALDELEALAEALAA 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499202172 256 YGASEYVKFDLTLVLHMSYYTGVVFEGYGNRLGVPLCSGGRYDELLSKFHRPAQATGFGVRIDLLVEALNGE 327
Cdd:COG3705  241 RGPDVRLTFDLSELRGYDYYTGIVFEAYAPGVGDPLARGGRYDGLLAAFGRARPATGFSLDLDRLLRALPAA 312
tRNA-synt_His pfam13393
Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP ...
 12-320 2.68e-77

Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP phosphoribosyltransferase regulatory subunits.


Pssm-ID: 433170 [Multi-domain]  Cd Length: 309  Bit Score: 241.34  E-value: 2.68e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172   12 GMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETVGVVSAILDQQLFKLLDQQGNTLVLRPDMTAPIARLVA 91
Cdd:pfam13393   1 GIRDLLPPEARRIEELRRRLLDLFRSWGYELVMPPLLEYLDSLLTGTGADLDQTFKLVDQSGRLLGLRADITPQVARIDA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172   92 SSLKdRAYPLRLAYQSNVYRAQQNEGGKPAEFEQLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVAIGHVGYVNAL 171
Cdd:pfam13393  81 HRLN-RPGPLRLCYAGSVLRTRPKGLGRSREPLQVGAELIGHAGIEADAEIISLLLEALAAAGVPGVTLDLGHVGLVRAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  172 LMDVVGNEQRADRLRRFLYEKNYVGYREHVKSLNLSTIDKSRLMNLLSLRGGRAAIEEARGLI-QTEKGKTALAEMTKLY 250
Cdd:pfam13393 160 LEAAGLSEALEEALRAALQRKDAAELAELAAEAGLPPALRRALLALPDLYGGPEVLDEARAALpGLPALQEALDELEALA 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  251 EVLESYGASEYVKFDLTLVLHMSYYTGVVFEGYGNRLGVPLCSGGRYDELLSKFHRPAQATGFGVRIDLL 320
Cdd:pfam13393 240 ALLEALGDGVRLTFDLAELRGYEYYTGIVFAAYAPGVGEPLARGGRYDDLGAAFGRARPATGFSLDLEAL 309
HisRS-like_core cd00773
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. ...
 21-324 5.77e-70

Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. This domain is also found at the C-terminus of eukaryotic GCN2 protein kinase and at the N-terminus of the ATP phosphoribosyltransferase accessory subunit, HisZ. HisZ along with HisG catalyze the first reaction in histidine biosynthesis. HisZ is found only in a subset of bacteria and differs from HisRS in lacking a C-terminal anti-codon binding domain.


Pssm-ID: 238396 [Multi-domain]  Cd Length: 261  Bit Score: 220.94  E-value: 5.77e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  21 YKTKKNICDQMTEEINLWGYDMIETPTLEYYET-VGVVSAILDQQLFKLLDQQGNTLVLRPDMTAPIARLVASSLKDRAY 99
Cdd:cd00773    2 AALRRYIEDTLREVFERYGYEEIDTPVFEYTELfLRKSGDEVSKEMYRFKDKGGRDLALRPDLTAPVARAVAENLLSLPL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 100 PLRLAYQSNVYRAQQNEGGKPAEFEQLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVAIGHVGYVNALLMDVVGNE 179
Cdd:cd00773   82 PLKLYYIGPVFRYERPQKGRYREFYQVGVEIIGSDSPLADAEVIALAVEILEALGLKDFQIKINHRGILDGIAGLLEDRE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 180 QRADRLRRFLyeknyvgyrehvkslnlstidksrlmnllslrggraaieeargliqtekGKTALAEMTKLYEVLESYGAS 259
Cdd:cd00773  162 EYIERLIDKL-------------------------------------------------DKEALAHLEKLLDYLEALGVD 192

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499202172 260 EYVKFDLTLVLHMSYYTGVVFEGYGNRLGV--PLCSGGRYDELLS-KFHRPAQATGFGVRIDLLVEAL 324
Cdd:cd00773  193 IKYSIDLSLVRGLDYYTGIVFEAVADGLGAqgSIAGGGRYDGLLEeFGGEDVPAVGFAIGLERLLLAL 260
HisS COG0124
Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Histidyl-tRNA ...
 6-364 2.15e-62

Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Histidyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439894 [Multi-domain]  Cd Length: 422  Bit Score: 206.51  E-value: 2.15e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172   6 MFEKPFGMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETV--GVVSAILDQQLFKLLDQQGNTLVLRPDMT 83
Cdd:COG0124    3 KIQAPRGTRDILPEESAKWQYVEDTIREVFERYGFQEIRTPIFEYTELFarKIGEDIVEKEMYTFEDRGGRSLTLRPEGT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  84 APIARLVASSLKDRAYPLRLAYQSNVYRaqqneGGKPA-----EFEQLGVELIGDGTASADGEVIALMIAALKRAGLSEF 158
Cdd:COG0124   83 APVARAVAEHGNELPFPFKLYYIGPVFR-----YERPQkgryrQFHQFGVEVIGSDSPLADAEVIALAADLLKALGLKDF 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 159 KVAIGHVGyvnallmdvvGNEQRADRLRRFLYEKNYVGYREHVKSLNLSTIDKSRLMNLLSLRGG--RAAIEEARGLIQT 236
Cdd:COG0124  158 TLEINSRG----------LPEERAEALLRYLDKLDKIGHEDVLDEDSQRRLETNPLRAILDSKGPdcQEVLADAPKLLDY 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 237 EkGKTALAEMTKLYEVLESYGASeyVKFDLTLVLHMSYYTGVVFEGYGNRLGVP--LCSGGRYDELLSKF-HRPAQATGF 313
Cdd:COG0124  228 L-GEEGLAHFEEVLELLDALGIP--YVIDPRLVRGLDYYTGTVFEIVTDGLGAQgsVCGGGRYDGLVEQLgGPPTPAVGF 304

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 499202172 314 GV---RIDLLVEALNgeIISNGHEQTCIL---FSNERRFEAIELARKKRANGEAVVL 364
Cdd:COG0124  305 AIgleRLLLLLEELG--LLPAAEPPPDVYvvpLGEEARAEALKLAQELRAAGIRVEL 359
hisS TIGR00442
histidyl-tRNA synthetase; This model finds a histidyl-tRNA synthetase in every completed ...
 8-359 3.52e-53

histidyl-tRNA synthetase; This model finds a histidyl-tRNA synthetase in every completed genome. Apparent second copies from Bacillus subtilis, Synechocystis sp., and Aquifex aeolicus are slightly shorter, more closely related to each other than to other hisS proteins, and actually serve as regulatory subunits for an enzyme of histidine biosynthesis. They were excluded from the seed alignment and score much lower than do single copy histidyl-tRNA synthetases of other genomes not included in the seed alignment. These putative second copies of HisS score below the trusted cutoff. The regulatory protein kinase GCN2 of Saccharomyces cerevisiae (YDR283c), and related proteins from other species designated eIF-2 alpha kinase, have a domain closely related to histidyl-tRNA synthetase that may serve to detect and respond to uncharged tRNA(his), an indicator of amino acid starvation; these regulatory proteins are not orthologous and so score below the noise cutoff. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273080 [Multi-domain]  Cd Length: 404  Bit Score: 181.52  E-value: 3.52e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172    8 EKPFGMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYE----TVGVVSAILDQQLFKLLDQQGNTLVLRPDMT 83
Cdd:TIGR00442   1 QKPRGTRDFLPEEMIKWQYIEETIREVFERYGFKEIRTPIFEYTElfkrKVGEETDIVSKEMYTFKDKGGRSLTLRPEGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172   84 APIARLVASSLKDRAYPLRLAYQSNVYRAQQNEGGKPAEFEQLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVAIG 163
Cdd:TIGR00442  81 APVARAVIENKLLLPKPFKLYYIGPMFRYERPQKGRYRQFHQFGVEVIGSDSPLADAEIIALAADILKELGLKDFTLEIN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  164 HVGYVNALLmdvvgnEQRADrLRRFLyEKnyvgYREHVKSLNLSTIDKSRLMNLLSLRGG-RAAIEEARGLIQtEKGKTA 242
Cdd:TIGR00442 161 SLGILEGRL------EYREA-LIRYL-DK----HKDKLGEDSVRRLEKNPLRILDSKNEKiQELLKNAPKILD-FLCEES 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  243 LAEMTKLYEVLESYGASeyVKFDLTLVLHMSYYTGVVFEGYGNRLGVP--LCSGGRYDELLSKF-HRPAQATGFGVRIDL 319
Cdd:TIGR00442 228 RAHFEELKELLDALGIP--YKIDPSLVRGLDYYTGTVFEFVTDDLGAQgsICGGGRYDGLVEELgGPPTPAVGFAIGIER 305

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 499202172  320 LVEALNGEIISNGHEQTC----ILFSNERRFEAIELARKKRANG 359
Cdd:TIGR00442 306 LILLLEELGLIPPPSKKPdvyvVPLGEEAELEALKLAQKLRKAG 349
PRK12421 PRK12421
ATP phosphoribosyltransferase regulatory subunit; Provisional
 10-363 2.00e-39

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 237098  Cd Length: 392  Bit Score: 144.73  E-value: 2.00e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  10 PFGMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETV-GVVSAILDQQLFKLLDQ-QGNTLVLRPDMTAPIA 87
Cdd:PRK12421  10 PDGVADVLPEEAQKIERLRRRLLDLFASRGYQLVMPPLIEYLESLlTGAGQDLKLQTFKLIDQlSGRLMGVRADITPQVA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  88 RLVASSLKdRAYPLRLAYQSNVYRAqqneggKPAEFE------QLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVA 161
Cdd:PRK12421  90 RIDAHLLN-REGVARLCYAGSVLHT------LPQGLFgsrtplQLGAELYGHAGIEADLEIIRLMLGLLRNAGVPALHLD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 162 IGHVGYVNALLMDVVGNEQRADRLRRFLYEKNYVGYREHVKSLNLSTIDKSRLMNLLSLRGGRAAIEEARG-LIQTEKG- 239
Cdd:PRK12421 163 LGHVGIFRRLAELAGLSPEEEEELFDLLQRKALPELAEVCQNLGVGSDLRRMFYALARLNGGLEALDRALSvLALQDAAi 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 240 KTALAEMTKLYEVLESYGASEYVKFDLTLVLHMSYYTGVVFEGYGNRLGVPLCSGGRYDELLSKFHRPAQATGFGVRIDL 319
Cdd:PRK12421 243 RQALDELKTLAAHLKNRWPELPVSIDLAELRGYHYHTGLVFAAYIPGRGQALARGGRYDGIGEAFGRARPATGFSMDLKE 322

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 499202172 320 LVEALNGEIisnghEQTCIL--FSNERRFEA-IELArkkRANGEAVV 363
Cdd:PRK12421 323 LLALQFLEE-----EAGAILapWGDDPDLLAaIAEL---RQQGERVV 361
PLN02530 PLN02530
histidine-tRNA ligase
 8-322 2.79e-27

histidine-tRNA ligase


Pssm-ID: 178145 [Multi-domain]  Cd Length: 487  Bit Score: 112.91  E-value: 2.79e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172   8 EKPFGMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYyETVGVVSA--ILDQQLFKLLDQQGNTLVLRPDMTAP 85
Cdd:PLN02530  71 NPPKGTRDFPPEDMRLRNWLFDHFREVSRLFGFEEVDAPVLES-EELYIRKAgeEITDQLYNFEDKGGRRVALRPELTPS 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  86 IARLVASSLKDRAYPLRLAYQSNVYRAQQNEGGKPAEFEQLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVAIGhv 165
Cdd:PLN02530 150 LARLVLQKGKSLSLPLKWFAIGQCWRYERMTRGRRREHYQWNMDIIGVPGVEAEAELLAAIVTFFKRVGITSSDVGIK-- 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 166 gyVNA--LLMDV-----VGNEQRA------DRLRRFLYEKnyvgYREHVKSLNLS--TIDKsrLMNLLSLRggraAIEEA 230
Cdd:PLN02530 228 --VSSrkVLQAVlksygIPEESFApvcvivDKLEKLPREE----IEKELDTLGVSeeAIEG--ILDVLSLK----SLDDL 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 231 RGLIQTEKGktALAEMTKLYEVLESYGASEYVKFDLTLVLHMSYYTGVVFEGYgNRLGV--PLCSGGRYDELLSKF---H 305
Cdd:PLN02530 296 EALLGADSE--AVADLKQLFSLAEAYGYQDWLVFDASVVRGLAYYTGIVFEGF-DRAGKlrAICGGGRYDRLLSTFggeD 372

                        330
                 ....*....|....*....
gi 499202172 306 RPAQATGFG--VRIDLLVE 322
Cdd:PLN02530 373 TPACGFGFGdaVIVELLKE 391
PLN02972 PLN02972
Histidyl-tRNA synthetase
 10-327 1.97e-22

Histidyl-tRNA synthetase


Pssm-ID: 215525 [Multi-domain]  Cd Length: 763  Bit Score: 99.58  E-value: 1.97e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  10 PFGMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETVGVVSAILDQQLFKLLDQQGNTLVLRPDMTAPIARL 89
Cdd:PLN02972 330 PKGTRDFAKEQMAIREKAFSIITSVFKRHGATALDTPVFELRETLMGKYGEDSKLIYDLADQGGELCSLRYDLTVPFARY 409

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  90 VA----SSLKdrayplrlAYQ-SNVYRAQQNEGGKPAEFEQLGVELIGD-GTASADGEVIALMIAALKRAGLSEFKVAIG 163
Cdd:PLN02972 410 VAmngiTSFK--------RYQiAKVYRRDNPSKGRYREFYQCDFDIAGVyEPMGPDFEIIKVLTELLDELDIGTYEVKLN 481

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 164 HVGYVNALL--MDVVGNEQRA-----DRLRRFLYEKNYvgyREHVKSLNLSTIDKSRLMNLLSLRGGRAAI-----EEAR 231
Cdd:PLN02972 482 HRKLLDGMLeiCGVPPEKFRTicssiDKLDKQSFEQVK---KEMVEEKGLSNETADKIGNFVKERGPPLELlsklrQEGS 558

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 232 GLIQTEKGKTALAEMTKLYEVLESYGASEYVKFDLTLVLHMSYYTGVVFEG--YGNRLGvPLCSGGRYDELLSKF---HR 306
Cdd:PLN02972 559 EFLGNASSRAALDELEIMFKALEKSKAIGKIVFDLSLARGLDYYTGVIYEAvfKGAQVG-SIAAGGRYDNLVGMFsgkQV 637

                        330       340
                 ....*....|....*....|..
gi 499202172 307 PAQATGFGV-RIDLLVEALNGE 327
Cdd:PLN02972 638 PAVGVSLGIeRVFAIMEQQEEE 659
hisZ PRK12295
ATP phosphoribosyltransferase regulatory subunit; Provisional
 70-327 3.65e-22

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 183413 [Multi-domain]  Cd Length: 373  Bit Score: 96.93  E-value: 3.65e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  70 DQQGNTLVLRPDMTAPIARL-VASSLkdrAYPLRLAYQSNVYRAQqneGGKPAEFEQLGVELIGDG-TASADGEVIALMI 147
Cdd:PRK12295  54 DENGEELCLRPDFTIPVCRRhIATAG---GEPARYAYLGEVFRQR---RDRASEFLQAGIESFGRAdPAAADAEVLALAL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 148 AALKRAGLSEFKVAIGHVGYVNALL--------------------------------MDVVGNEQRADRLRRFLYEKNYV 195
Cdd:PRK12295 128 EALAALGPGDLEVRLGDVGLFAALVdalglppgwkrrllrhfgrprsldallarlagPRVDPLDEHAGVLAALADEAAAR 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 196 GYREHVKSLN-LSTIDK-------SRLMNLLSLRGGRAAIEEARGLIQ-----TEKGKTALAEMT--------KLYEVLE 254
Cdd:PRK12295 208 ALVEDLMSIAgISPVGGrspaeiaRRLLEKAALAAAARLPAEALAVLErflaiSGPPDAALAALRalaadaglDLDAALD 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 255 SYGAS-----------EYVKFDLTLVLHMSYYTGVVFEGYGNRLG-VPLCSGGRYDELLSKFHRPAQ--ATGFGVRIDLL 320
Cdd:PRK12295 288 RFEARlaalaargidlERLRFSASFGRPLDYYTGFVFEIRAAGNGdPPLAGGGRYDGLLTRLGAGEPipAVGFSIWLDRL 367


                 ....*..
gi 499202172 321 vEALNGE 327
Cdd:PRK12295 368 -AALGGA 373
PRK12420 PRK12420
histidyl-tRNA synthetase; Provisional
 12-362 9.42e-19

histidyl-tRNA synthetase; Provisional


Pssm-ID: 237097 [Multi-domain]  Cd Length: 423  Bit Score: 87.48  E-value: 9.42e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  12 GMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETV----GVVSAILdQQLFKLLDQQGNTLVLRPDMTAPIA 87
Cdd:PRK12420   9 GTKDYLPEEQVLRNKIKRALEDVFERYGCKPLETPTLNMYELMsskyGGGDEIL-KEIYTLTDQGKRDLALRYDLTIPFA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  88 RLVASSLKDRAyPLRLAYQSNVYRAQQNEGGKPAEFEQLGVELIGDGTASADGEVIALMIAALKRAGLsEFKVAIGHVGY 167
Cdd:PRK12420  88 KVVAMNPNIRL-PFKRYEIGKVFRDGPIKQGRFREFIQCDVDIVGVESVMAEAELMSMAFELFRRLNL-EVTIQYNNRKL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 168 VNALLMDVVGNEQRA-------DRLRRFLYEknyvGYREHVKSLNLSTIDKSRLMNLLsLRGGRAAIEEARGLIQTEKGK 240
Cdd:PRK12420 166 LNGILQAIGIPTELTsdvilslDKIEKIGID----GVRKDLLERGISEEMADTICNTV-LSCLQLSIADFKEAFNNPLVA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 241 TALAEMTKLYEVLESYGASEYVKFDLTLVLHMSYYTGVVFEGY--GNRLGVPLCSGGRYDELLSKF---HRPAQATGFGV 315
Cdd:PRK12420 241 EGVNELQQLQQYLIALGINENCIFNPFLARGLTMYTGTVYEIFlkDGSITSSIGSGGRYDNIIGAFrgdDMNYPTVGISF 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499202172 316 RIDLLVEALNGE----------IISNGHEQTCILFSNE-RRFEAI----ELARKK------RANGEAV 362
Cdd:PRK12420 321 GLDVIYTALSQKetisstadvfIIPLGTELQCLQIAQQlRSTTGLkvelELAGRKlkkalnYANKENI 388
syh CHL00201
histidine-tRNA synthetase; Provisional
 12-329 1.36e-17

histidine-tRNA synthetase; Provisional


Pssm-ID: 164576 [Multi-domain]  Cd Length: 430  Bit Score: 83.80  E-value: 1.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  12 GMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLE----YYETVGVVSAILDQQLFKLLDQQGNTLVLRPDMTAPIA 87
Cdd:CHL00201   9 GTKDILPDEINYWQFIHDKALTLLSLANYSEIRTPIFEnsslYDRGIGETTDIVNKEMYRFTDRSNRDITLRPEGTAGIV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  88 RLVASSLKDRAYPL-RLAYQSNVYRAQQNEGGKPAEFEQLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVAIGHVG 166
Cdd:CHL00201  89 RAFIENKMDYHSNLqRLWYSGPMFRYERPQSGRQRQFHQLGIEFIGSIDARADTEVIHLAMQIFNELQVKNLILDINSIG 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 167 YVnallmdvvgnEQRAdrlrrfLYEKNYVGYREHVKSlNLSTIDKSRLMNlLSLRggraaIEEARGLiqteKGKTALAEM 246
Cdd:CHL00201 169 KL----------EDRQ------SYQLKLVEYLSQYQD-DLDTDSQNRLYS-NPIR-----ILDSKNL----KTQEILDGA 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 247 TKL--YEVLES----YGASEYV-------KFDLTLVLHMSYYTGVVFEGYGNRLGV--PLCSGGRYDELLSKFHRPAQ-A 310
Cdd:CHL00201 222 PKIsdFLSLEStehfYDVCTYLnllnipyKINYKLVRGLDYYNDTAFEIKTLSSNGqdTICGGGRYDSLIHQLGGPKTpA 301

                        330
                 ....*....|....*....
gi 499202172 311 TGFGVRIDLLVEALNGEII 329
Cdd:CHL00201 302 VGCAIGLERLLLIAKDNII 320
hisZ PRK12293
ATP phosphoribosyltransferase regulatory subunit; Provisional
 39-326 1.10e-04

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 183411  Cd Length: 281  Bit Score: 43.45  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172  39 GYDMIETPTLEYYETVGVVSAildQQLFKLLDQQGNTLVLRPDMTAPIARLVASSLKDRAYPLRLAYQSNVYRAQQNegg 118
Cdd:PRK12293  37 GFEEIVTPFFSYHQHQSIADE---KELIRFSDEKNHQISLRADSTLDVVRIVTKRLGRSTEHKKWFYIQPVFRYPSN--- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 119 kpaEFEQLGVELIGDGTASadgEVIALMIAALKRAGLSEFkVAIGHVgyvnallmdvvgneqradRLRRFLYEKNYVGYr 198
Cdd:PRK12293 111 ---EIYQIGAELIGEEDLS---EILNIAAEIFEELELEPI-LQISNI------------------KIPKLVAEILGLDI- 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499202172 199 EHVKSLNLSTIDK------SRLMNLLSLRGGRAAIEEARGLIQtekgktalAEMTKLYEVLESYgasEYVKFDLTLVLH- 271
Cdd:PRK12293 165 EVFKKGQIEKLLAqnvpwlNKLVRIKTLEDLDEVIELVPDEIK--------EELEKLKELAESI---KYENLVIAPLYYa 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 499202172 272 -MSYYTGVVFEGY-GNRLgvpLCSGGRY--DELlskfhrpaQATGFGVRIDLLVEALNG 326
Cdd:PRK12293 234 kMRYYDDLFFRFFdGNST---LASGGNYeiDGI--------SSSGFALYTDNLIEILLK 281
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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