NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|499174102|ref|WP_010871689|]
View 

MULTISPECIES: class I SAM-dependent methyltransferase [unclassified Synechocystis]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10552639)

class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Methyltransf_14 pfam08484
C-methyltransferase C-terminal domain; This domain is found in bacterial C-methyltransferase ...
 240-395 4.21e-68

C-methyltransferase C-terminal domain; This domain is found in bacterial C-methyltransferase proteins. This domain is found C-terminal to methyltransferase domains such as pfam08241 or pfam08242. But this domain is not a methyltransferase.


:

Pssm-ID: 430022  Cd Length: 160  Bit Score: 212.32  E-value: 4.21e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499174102  240 PIHGGSIVGFVTHQ--GKRQPTERLQAMRQSEIDEKSNDYQTYLDFAQRIETMKAENLAYLDEAKQAGKTVWGFGAPVKG 317
Cdd:pfam08484   1 PTHGGSLRVYAARKegGARPVSPAVAALLAEERAAGLDTLATYAGFAERVERVKDELLALLIDLKAEGKRVAGYGAAAKG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499174102  318 NTLLNYFGIGTQYLDYLVEKNELRRGLVSPGMHIPLLIEKELTTL-PDIYYVLAWNFKREILANNQHLIDQGVEFFFPV 395
Cdd:pfam08484  81 NTLLNYCGIGPDLLDYVVDRNPAKQGRYTPGTHIPIVPPEKLREDrPDYVLILPWNLADEIMAQLAEYREWGGKFIVPV 159
Methyltransf_13 pfam08421
Putative zinc binding domain; This domain is found at the N-terminus of bacterial ...
 3-63 1.69e-24

Putative zinc binding domain; This domain is found at the N-terminus of bacterial methyltransferases and contains four conserved cysteines suggesting a potential zinc binding domain.


:

Pssm-ID: 429987  Cd Length: 62  Bit Score: 95.34  E-value: 1.69e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499174102    3 CRVCDSTRLDLAIDLGEQPWCNHFLTPAEVGQ-EPYYPLRVLYCQDCGTVQLDYTVKKEIMF 63
Cdd:pfam08421   1 CRLCGSPLLTPFLDLGRQPLANAFLTPEQLDQpEPFYPLRLVVCEDCGLVQLEEVVPPEELF 62
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 80-231 4.25e-15

Methyltransferase domain; This family appears to be a methyltransferase domain.


:

Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 72.46  E-value: 4.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499174102   80 FARVAQEVDERFFANTPGKSVLDIGSNDGTQLKHFQALGYDVLGVESSKTTAKIANDAGVPTLndfFNLEVVEKLGRKFS 159
Cdd:pfam13489   6 ERLLADLLLRLLPKLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALLNVRFDQ---FDEQEAAVPAGKFD 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499174102  160 AINAAGVFFHLEELHSVTEGIREALAEDGVFVVQ----FLYMKRIVENLAFDQIYHEHLLYYNLQTIEVLLNRHGL 231
Cdd:pfam13489  83 VIVAREVLEHVPDPPALLRQIAALLKPGGLLLLStplaSDEADRLLLEWPYLRPRNGHISLFSARSLKRLLEEAGF 158
 
Name Accession Description Interval E-value
Methyltransf_14 pfam08484
C-methyltransferase C-terminal domain; This domain is found in bacterial C-methyltransferase ...
 240-395 4.21e-68

C-methyltransferase C-terminal domain; This domain is found in bacterial C-methyltransferase proteins. This domain is found C-terminal to methyltransferase domains such as pfam08241 or pfam08242. But this domain is not a methyltransferase.


Pssm-ID: 430022  Cd Length: 160  Bit Score: 212.32  E-value: 4.21e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499174102  240 PIHGGSIVGFVTHQ--GKRQPTERLQAMRQSEIDEKSNDYQTYLDFAQRIETMKAENLAYLDEAKQAGKTVWGFGAPVKG 317
Cdd:pfam08484   1 PTHGGSLRVYAARKegGARPVSPAVAALLAEERAAGLDTLATYAGFAERVERVKDELLALLIDLKAEGKRVAGYGAAAKG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499174102  318 NTLLNYFGIGTQYLDYLVEKNELRRGLVSPGMHIPLLIEKELTTL-PDIYYVLAWNFKREILANNQHLIDQGVEFFFPV 395
Cdd:pfam08484  81 NTLLNYCGIGPDLLDYVVDRNPAKQGRYTPGTHIPIVPPEKLREDrPDYVLILPWNLADEIMAQLAEYREWGGKFIVPV 159
Methyltransf_13 pfam08421
Putative zinc binding domain; This domain is found at the N-terminus of bacterial ...
 3-63 1.69e-24

Putative zinc binding domain; This domain is found at the N-terminus of bacterial methyltransferases and contains four conserved cysteines suggesting a potential zinc binding domain.


Pssm-ID: 429987  Cd Length: 62  Bit Score: 95.34  E-value: 1.69e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499174102    3 CRVCDSTRLDLAIDLGEQPWCNHFLTPAEVGQ-EPYYPLRVLYCQDCGTVQLDYTVKKEIMF 63
Cdd:pfam08421   1 CRLCGSPLLTPFLDLGRQPLANAFLTPEQLDQpEPFYPLRLVVCEDCGLVQLEEVVPPEELF 62
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 80-231 4.25e-15

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 72.46  E-value: 4.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499174102   80 FARVAQEVDERFFANTPGKSVLDIGSNDGTQLKHFQALGYDVLGVESSKTTAKIANDAGVPTLndfFNLEVVEKLGRKFS 159
Cdd:pfam13489   6 ERLLADLLLRLLPKLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALLNVRFDQ---FDEQEAAVPAGKFD 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499174102  160 AINAAGVFFHLEELHSVTEGIREALAEDGVFVVQ----FLYMKRIVENLAFDQIYHEHLLYYNLQTIEVLLNRHGL 231
Cdd:pfam13489  83 VIVAREVLEHVPDPPALLRQIAALLKPGGLLLLStplaSDEADRLLLEWPYLRPRNGHISLFSARSLKRLLEEAGF 158
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
90-232 7.14e-14

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 69.26  E-value: 7.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499174102  90 RFFANTPGKSVLDIGSNDGTQLKHFQALGYDVLGVESSKTTAKIANDAGVPTlnDFFNLEVVE--KLGRKFSAINAAGVF 167
Cdd:COG4976   40 ARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGVYD--RLLVADLADlaEPDGRFDLIVAADVL 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499174102 168 FHLEELHSVTEGIREALAEDGVFVvqflymkrivenLAFDQIYHEHLLYYNLQTIEVLLNRHGLS 232
Cdd:COG4976  118 TYLGDLAAVFAGVARALKPGGLFI------------FSVEDADGSGRYAHSLDYVRDLLAAAGFE 170
 
Name Accession Description Interval E-value
Methyltransf_14 pfam08484
C-methyltransferase C-terminal domain; This domain is found in bacterial C-methyltransferase ...
 240-395 4.21e-68

C-methyltransferase C-terminal domain; This domain is found in bacterial C-methyltransferase proteins. This domain is found C-terminal to methyltransferase domains such as pfam08241 or pfam08242. But this domain is not a methyltransferase.


Pssm-ID: 430022  Cd Length: 160  Bit Score: 212.32  E-value: 4.21e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499174102  240 PIHGGSIVGFVTHQ--GKRQPTERLQAMRQSEIDEKSNDYQTYLDFAQRIETMKAENLAYLDEAKQAGKTVWGFGAPVKG 317
Cdd:pfam08484   1 PTHGGSLRVYAARKegGARPVSPAVAALLAEERAAGLDTLATYAGFAERVERVKDELLALLIDLKAEGKRVAGYGAAAKG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499174102  318 NTLLNYFGIGTQYLDYLVEKNELRRGLVSPGMHIPLLIEKELTTL-PDIYYVLAWNFKREILANNQHLIDQGVEFFFPV 395
Cdd:pfam08484  81 NTLLNYCGIGPDLLDYVVDRNPAKQGRYTPGTHIPIVPPEKLREDrPDYVLILPWNLADEIMAQLAEYREWGGKFIVPV 159
Methyltransf_13 pfam08421
Putative zinc binding domain; This domain is found at the N-terminus of bacterial ...
 3-63 1.69e-24

Putative zinc binding domain; This domain is found at the N-terminus of bacterial methyltransferases and contains four conserved cysteines suggesting a potential zinc binding domain.


Pssm-ID: 429987  Cd Length: 62  Bit Score: 95.34  E-value: 1.69e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499174102    3 CRVCDSTRLDLAIDLGEQPWCNHFLTPAEVGQ-EPYYPLRVLYCQDCGTVQLDYTVKKEIMF 63
Cdd:pfam08421   1 CRLCGSPLLTPFLDLGRQPLANAFLTPEQLDQpEPFYPLRLVVCEDCGLVQLEEVVPPEELF 62
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 80-231 4.25e-15

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 72.46  E-value: 4.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499174102   80 FARVAQEVDERFFANTPGKSVLDIGSNDGTQLKHFQALGYDVLGVESSKTTAKIANDAGVPTLndfFNLEVVEKLGRKFS 159
Cdd:pfam13489   6 ERLLADLLLRLLPKLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALLNVRFDQ---FDEQEAAVPAGKFD 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499174102  160 AINAAGVFFHLEELHSVTEGIREALAEDGVFVVQ----FLYMKRIVENLAFDQIYHEHLLYYNLQTIEVLLNRHGL 231
Cdd:pfam13489  83 VIVAREVLEHVPDPPALLRQIAALLKPGGLLLLStplaSDEADRLLLEWPYLRPRNGHISLFSARSLKRLLEEAGF 158
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
90-232 7.14e-14

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 69.26  E-value: 7.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499174102  90 RFFANTPGKSVLDIGSNDGTQLKHFQALGYDVLGVESSKTTAKIANDAGVPTlnDFFNLEVVE--KLGRKFSAINAAGVF 167
Cdd:COG4976   40 ARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGVYD--RLLVADLADlaEPDGRFDLIVAADVL 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499174102 168 FHLEELHSVTEGIREALAEDGVFVvqflymkrivenLAFDQIYHEHLLYYNLQTIEVLLNRHGLS 232
Cdd:COG4976  118 TYLGDLAAVFAGVARALKPGGLFI------------FSVEDADGSGRYAHSLDYVRDLLAAAGFE 170
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 96-194 1.66e-13

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 66.96  E-value: 1.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499174102  96 PGKSVLDIGSNDGTQLKHFQALGYDVLGVESSKTTAKIANDAGVPTLNDFF--NLEVVEKLGRKFSAINAAGVFFHLEEL 173
Cdd:COG2227   24 AGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAELNVDFVqgDLEDLPLEDGSFDLVICSEVLEHLPDP 103

                         90       100
                 ....*....|....*....|.
gi 499174102 174 HSVTEGIREALAEDGVFVVQF 194
Cdd:COG2227  104 AALLRELARLLKPGGLLLLST 124
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 101-190 5.63e-07

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 47.36  E-value: 5.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499174102  101 LDIGSNDGTQLKHFQAL--GYDVLGVESSKTTAKIA------NDAGVPTLNDFFNLEVVEKLGRKFSAINAAGVFFHLEE 172
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAlpGLEYTGLDISPAALEAArerlaaLGLLNAVRVELFQLDLGELDPGSFDVVVASNVLHHLAD 80

                          90
                  ....*....|....*...
gi 499174102  173 LHSVTEGIREALAEDGVF 190
Cdd:pfam08242  81 PRAVLRNIRRLLKPGGVL 98
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 96-194 1.21e-06

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 48.00  E-value: 1.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499174102  96 PGKSVLDIGSNDGTQLKHF-QALGYDVLGVESSKTTAKIAN----DAGVPT-----LNDFFNLEvvekLGRKFSAINAAG 165
Cdd:COG2230   51 PGMRVLDIGCGWGGLALYLaRRYGVRVTGVTLSPEQLEYAReraaEAGLADrvevrLADYRDLP----ADGQFDAIVSIG 126

                         90       100       110
                 ....*....|....*....|....*....|.
gi 499174102 166 VFFHL--EELHSVTEGIREALAEDGVFVVQF 194
Cdd:COG2230  127 MFEHVgpENYPAYFAKVARLLKPGGRLLLHT 157
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 80-192 1.25e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 47.68  E-value: 1.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499174102  80 FARVAQEVDERF-----FANTPGKSVLDIGSNDGTQLKHFQALGYDVLGVESSKTTAKIANDAGVptlNDFFNLEVV--- 151
Cdd:COG2226    1 FDRVAARYDGREallaaLGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAA---EAGLNVEFVvgd 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 499174102 152 -EKL---GRKFSAINAAGVFFHLEELHSVTEGIREALAEDGVFVV 192
Cdd:COG2226   78 aEDLpfpDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVV 122
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 101-192 6.38e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 41.50  E-value: 6.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499174102  101 LDIGSNDGTQLKHFQALGYDVLGVESSKTTAKIANDAGvPTLNDFFNLEVVEKLG---RKFSAINAAGVFFHLEELHSVT 177
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKA-PREGLTFVVGDAEDLPfpdNSFDLVLSSEVLHHVEDPERAL 79

                          90
                  ....*....|....*
gi 499174102  178 EGIREALAEDGVFVV 192
Cdd:pfam08241  80 REIARVLKPGGILII 94
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 100-188 2.17e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 37.16  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499174102  100 VLDIGSNDGTQLKHF-QALGYDVLGVESSKTTAKIAND-AGVPTLN------DFFNLEVVEklgRKFSAINAAGVFFHL- 170
Cdd:pfam13649   1 VLDLGCGTGRLTLALaRRGGARVTGVDLSPEMLERARErAAEAGLNvefvqgDAEDLPFPD---GSFDLVVSSGVLHHLp 77

                          90
                  ....*....|....*....
gi 499174102  171 -EELHSVTEGIREALAEDG 188
Cdd:pfam13649  78 dPDLEAALREIARVLKPGG 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH