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Conserved domains on  [gi|498499336|ref|WP_010800038|]
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MULTISPECIES: THUMP-like domain-containing protein [Parabacteroides]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Thump_like pfam18096
THUMP domain-like; This is a domain of unknown function found in bacteria.
 323-394 5.75e-15

THUMP domain-like; This is a domain of unknown function found in bacteria.


:

Pssm-ID: 465646  Cd Length: 76  Bit Score: 69.22  E-value: 5.75e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 498499336  323 GRSFVVEEVFPFTGKLCKG--ISGQIPRANITVRNFPLSVEELRKRTKIMDGG-DVYLFATT-QADNSKILVKCRK 394
Cdd:pfam18096   1 GRAFRILEVLPFSKKALKKllRERGIGKAEIKKRGFPLDPEELRKKLKIKDGGrTATLFLTRvGKAGRPVAILCER 76
CobL super family cl28096
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 85-156 1.33e-04

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


The actual alignment was detected with superfamily member COG2242:

Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 43.62  E-value: 1.33e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 498499336  85 KEDETLCDL---TGGLGIDSYYFSRKVRqVTYIERFPAYCEAARNNFSALGVDNITVMEGDSTMLISQLPRTD-VF 156
Cdd:COG2242  246 RPGDVLWDIgagSGSVSIEAARLAPGGR-VYAIERDPERAALIRANARRFGVPNVEVVEGEAPEALADLPDPDaVF 320
 
Name Accession Description Interval E-value
Thump_like pfam18096
THUMP domain-like; This is a domain of unknown function found in bacteria.
 323-394 5.75e-15

THUMP domain-like; This is a domain of unknown function found in bacteria.


Pssm-ID: 465646  Cd Length: 76  Bit Score: 69.22  E-value: 5.75e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 498499336  323 GRSFVVEEVFPFTGKLCKG--ISGQIPRANITVRNFPLSVEELRKRTKIMDGG-DVYLFATT-QADNSKILVKCRK 394
Cdd:pfam18096   1 GRAFRILEVLPFSKKALKKllRERGIGKAEIKKRGFPLDPEELRKKLKIKDGGrTATLFLTRvGKAGRPVAILCER 76
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 85-156 1.33e-04

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 43.62  E-value: 1.33e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 498499336  85 KEDETLCDL---TGGLGIDSYYFSRKVRqVTYIERFPAYCEAARNNFSALGVDNITVMEGDSTMLISQLPRTD-VF 156
Cdd:COG2242  246 RPGDVLWDIgagSGSVSIEAARLAPGGR-VYAIERDPERAALIRANARRFGVPNVEVVEGEAPEALADLPDPDaVF 320
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
105-142 6.92e-04

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 40.57  E-value: 6.92e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 498499336 105 SRKVRQVTYIERFPAYCEAARNNFSALGVDNITVMEGD 142
Cdd:PRK00312  97 AHLVRRVFSVERIKTLQWEAKRRLKQLGLHNVSVRHGD 134
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
92-145 4.39e-03

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 38.12  E-value: 4.39e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 498499336   92 DLTGGLGIDSYYFSRKVRQ---VTYIERFPAYCEAARNNFSALGVDNITVMEGDSTM 145
Cdd:pfam01135  79 EIGSGSGYLTACFARMVGEvgrVVSIEHIPELVEIARRNLEKLGLENVIVVVGDGRQ 135
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 89-190 9.35e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 35.48  E-value: 9.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498499336  89 TLCDLTGGLGIDSYYF-SRKVRQVTYIERFPAYCEAARNNFSALGVDNITVMEGDSTMLISQLPRT-DVFYIDParrgeg 166
Cdd:cd02440    1 RVLDLGCGTGALALALaSGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADESfDVIISDP------ 74

                         90       100
                 ....*....|....*....|....
gi 498499336 167 nkrvfALQDCEPDLPALLPELFRH 190
Cdd:cd02440   75 -----PLHHLVEDLARFLEEARRL 93
 
Name Accession Description Interval E-value
Thump_like pfam18096
THUMP domain-like; This is a domain of unknown function found in bacteria.
 323-394 5.75e-15

THUMP domain-like; This is a domain of unknown function found in bacteria.


Pssm-ID: 465646  Cd Length: 76  Bit Score: 69.22  E-value: 5.75e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 498499336  323 GRSFVVEEVFPFTGKLCKG--ISGQIPRANITVRNFPLSVEELRKRTKIMDGG-DVYLFATT-QADNSKILVKCRK 394
Cdd:pfam18096   1 GRAFRILEVLPFSKKALKKllRERGIGKAEIKKRGFPLDPEELRKKLKIKDGGrTATLFLTRvGKAGRPVAILCER 76
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 85-156 1.33e-04

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 43.62  E-value: 1.33e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 498499336  85 KEDETLCDL---TGGLGIDSYYFSRKVRqVTYIERFPAYCEAARNNFSALGVDNITVMEGDSTMLISQLPRTD-VF 156
Cdd:COG2242  246 RPGDVLWDIgagSGSVSIEAARLAPGGR-VYAIERDPERAALIRANARRFGVPNVEVVEGEAPEALADLPDPDaVF 320
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
74-156 2.23e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 42.33  E-value: 2.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498499336  74 EQTASYKQ---RLVKEDETLCDLTGGLGIDSYYFSRK-VRQVTYIERFPAYCEAARNNFSALGV-DNITVMEGDSTMLis 148
Cdd:COG4076   20 ERNDAFKAaieRVVKPGDVVLDIGTGSGLLSMLAARAgAKKVYAVEVNPDIAAVARRIIAANGLsDRITVINADATDL-- 97


                 ....*....
gi 498499336 149 QLP-RTDVF 156
Cdd:COG4076   98 DLPeKADVI 106
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 110-159 4.95e-04

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 40.55  E-value: 4.95e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 498499336 110 QVTYIERFPAYCEAARNNFSALGV-DNITVMEGDSTMLISQLPRT--DVFYID 159
Cdd:COG4122   43 RLTTIEIDPERAAIARENFARAGLaDRIRLILGDALEVLPRLADGpfDLVFID 95
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
105-142 6.92e-04

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 40.57  E-value: 6.92e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 498499336 105 SRKVRQVTYIERFPAYCEAARNNFSALGVDNITVMEGD 142
Cdd:PRK00312  97 AHLVRRVFSVERIKTLQWEAKRRLKQLGLHNVSVRHGD 134
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 110-145 7.25e-04

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 40.39  E-value: 7.25e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 498499336 110 QVTYIERFPAYCEAARNNFSALGVDNITVMEGDSTM 145
Cdd:PRK13942 103 KVVTIERIPELAEKAKKTLKKLGYDNVEVIVGDGTL 138
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
92-145 4.39e-03

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 38.12  E-value: 4.39e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 498499336   92 DLTGGLGIDSYYFSRKVRQ---VTYIERFPAYCEAARNNFSALGVDNITVMEGDSTM 145
Cdd:pfam01135  79 EIGSGSGYLTACFARMVGEvgrVVSIEHIPELVEIARRNLEKLGLENVIVVVGDGRQ 135
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 89-190 9.35e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 35.48  E-value: 9.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498499336  89 TLCDLTGGLGIDSYYF-SRKVRQVTYIERFPAYCEAARNNFSALGVDNITVMEGDSTMLISQLPRT-DVFYIDParrgeg 166
Cdd:cd02440    1 RVLDLGCGTGALALALaSGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADESfDVIISDP------ 74

                         90       100
                 ....*....|....*....|....
gi 498499336 167 nkrvfALQDCEPDLPALLPELFRH 190
Cdd:cd02440   75 -----PLHHLVEDLARFLEEARRL 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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