|
Name |
Accession |
Description |
Interval |
E-value |
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
4-420 |
5.45e-172 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 487.74 E-value: 5.45e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 4 FALVDCNSFYCSCERIFRPDLAQKAVVVLSNNDACIIARSREAKALGLKMGDPYFKVKRFLDQRGVTAFSSNYALYADVS 83
Cdd:PRK03609 2 FALCDVNSFYASCETVFRPDLRGKPVVVLSNNDGCVIARSAEAKALGIKMGDPWFKQKDLFRRCGVVCFSSNYELYADMS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 84 NRVMRTISTLVASIEVYSVDECWCDLTGMPG--DLEQLGRDIQARVRQWVNIPVGVGIGPTKTLAKLAQWAGKNW-PATG 160
Cdd:PRK03609 82 NRVMSTLEELSPRVEIYSIDEAFCDLTGVRNcrDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWqRQTG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 161 GVVNLMDSQRQQKLLKLAPVGEVWGVGRKLSSQLETLGIKTAFDLASADPRHIGRMFSKVLERTARELRGEQWLKMHDDP 240
Cdd:PRK03609 162 GVVDLSNLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFNVVLERTVRELRGEPCLSLEEFA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 241 DPKKEIVSSKMFGRRVYLLEELRQAVAAYTTRAAEKLREQDSVCSELVVSVQTSPFADPAERYWNGARMLLPTPTADTRD 320
Cdd:PRK03609 242 PTKQEIVCSRSFGERITDYESMRQAICSYAARAAEKLRGEHQYCRFISTFVKTSPFALNEPYYGNSASVKLLTPTQDSRD 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 321 LIQAANQGLHGIYRDGFAYSKCTIQLCR-----LSQLeGLTHDMfapQPRRNVDSLMATMDLVNERFGRGALRVASIPVE 395
Cdd:PRK03609 322 IIAAATRALDAIWRDGHRYQKAGVMLGDffsqgVAQL-NLFDDN---APRPGSEQLMKVLDTLNAKSGKGTLYFAGQGIA 397
|
410 420
....*....|....*....|....*
gi 498492145 396 AGWAMRREMLSPSYTTSWRELPRAR 420
Cdd:PRK03609 398 QQWQMKREMLSPRYTTRWSDLLRVK 422
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
5-346 |
3.48e-169 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 477.43 E-value: 3.48e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 5 ALVDCNSFYCSCERIFRPDLAQKAVVVLSNNDACIIARSREAKALGLKMGDPYFKVKRFLDQRGVTAFSSNYALYADVSN 84
Cdd:cd01700 1 ALVDCNSFYASCERVFRPLLLGRPLVVLSNNDGCVIARSPEAKALGIKMGSPYFKVPDLLERHGVAVFSSNYALYGDMSR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 85 RVMRTISTLVASIEVYSVDECWCDLTGMP--GDLEQLGRDIQARVRQWVNIPVGVGIGPTKTLAKLAQWAGKNWPATGGV 162
Cdd:cd01700 81 RIMSILERFSPDVEVYSIDESFLDLTGSLrfGDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLAKKKNPYGGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 163 VNLMDSQRQQKLLKLAPVGEVWGVGRKLSSQLETLGIKTAFDLASADPRHIGRMFSKVLERTARELRGEQWLKMHDDPDP 242
Cdd:cd01700 161 VDLTDEEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLEEYPPP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 243 KKEIVSSKMFGRRVYLLEELRQAVAAYTTRAAEKLREQDSVCSELVVSVQTSPFADPAERYWNGARmlLPTPTADTRDLI 322
Cdd:cd01700 241 KKSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTSGFSRQPKYYSATNT--LPYPTNDTREIV 318
|
330 340
....*....|....*....|....
gi 498492145 323 QAANQGLHGIYRDGFAYSKCTIQL 346
Cdd:cd01700 319 KAALRLLYAIYRPGYAYRKAGVML 342
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
3-339 |
1.47e-109 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 325.56 E-value: 1.47e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 3 VFALVDCNSFYCSCERIFRPDLAQKAVVVLS-NNDACIIARSREAKALGLKMGDPYFKVKRFLdqRGVTAFSSNYALYAD 81
Cdd:COG0389 2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGdNNRGVVAAASYEARAFGVRSGMPLFQARRLC--PDLVVLPPDFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 82 VSNRVMRTISTLVASIEVYSVDECWCDLTGMP---GDLEQLGRDIQARVRQWVNIPVGVGIGPTKTLAKLAQWAGKnwpa 158
Cdd:COG0389 80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGSArlfGSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAK---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 159 TGGVVNLMDSQRQQKLLKLaPVGEVWGVGRKLSSQLETLGIKTAFDLASADPRHIGRMFSKVLERTARELRGEqwlkmHD 238
Cdd:COG0389 156 PDGLTVIPPGEVAAFLAPL-PVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGI-----DP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 239 DP----DPKKEIVSSKMFGRRVYLLEELRQAVAAYTTRAAEKLREQDSVCSELVVSVQTSPFADpaerywNGARMLLPTP 314
Cdd:COG0389 230 RPveprRPRKSIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRT------TTRSRTLPEP 303
|
330 340
....*....|....*....|....*
gi 498492145 315 TADTRDLIQAANQGLHGIYRDGFAY 339
Cdd:COG0389 304 TDDTAELLRAARELLERIYRPGRPV 328
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
7-347 |
7.35e-47 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 164.07 E-value: 7.35e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 7 VDCNSFYCSCERIFRPDLAQKAVVVLSNNDA--CIIARSREAKALGLKMGDPYFKVKRFLdqRGVTAFSSNYALYADVSN 84
Cdd:cd00424 3 IDFDNFFASVEQLARPELKGRPVVVVPFNSDstCVIACSYEARKYGVKRGMPVREARKMC--PNLILVPARLDLYRRLSE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 85 RVMRTISTLVASIEVYSVDECWCDLTGM---PGDLEQLGRDIQARVRQWVN-IPVGVGIGPTKTLAKLAQWAGKnwpaTG 160
Cdd:cd00424 81 RLLSELEEVAPLVEVASIDELFLDLTGSarlLGLGSEVALRIKRHIAEQLGgITASIGIASNKLLAKLAAKYAK----PD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 161 GVVNLMDSQRQQKLLKLaPVGEVWGVGRKLSSQLETLGIKTAFDLASADPRHI-GRMFSKVLERTARELRGEqwlkmhDD 239
Cdd:cd00424 157 GLTILDPEDLPGFLSKL-PLTDLPGIGAVTAKRLEAVGINPIGDLLAASPDALlALWGGVSGERLWYALRGI------DD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 240 -----PDPKKEIVSSKMFGRRVYLLEELRQAVAAYTTRAAEKLREQDSVCSELVVSVQT--SPFADPAERYWNGARMLLP 312
Cdd:cd00424 230 eplspPRPRKSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTvdGRWSGHADIPSRSAPRPIS 309
|
330 340 350
....*....|....*....|....*....|....*
gi 498492145 313 TPTADTRDLIQAANQGLHgIYRDGFAYSKCTIQLC 347
Cdd:cd00424 310 TEDGELLHALDKLWRALL-DDKGPRRLRRLGVRLS 343
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
7-335 |
3.09e-45 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 159.61 E-value: 3.09e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 7 VDCNSFYCSCERIFRPDLAQKAVVVLSNNDACIIAR-SREAKALGLKMGDPYFKVKRFLDQRGVtaFSSNYALYADVSNR 85
Cdd:cd03586 3 IDMDAFYASVEQRDNPELKGKPVAVGGSSDRGVVSTaSYEARKFGVRSAMPIFQAKKLCPNLIF--VPPRFDKYREVSRQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 86 VMRTISTLVASIEVYSVDECWCDLTGM---PGDLEQLGRDIQARVRQWVNIPVGVGIGPTKTLAKLAqwAGKNWPAtgGV 162
Cdd:cd03586 81 IMEILREYTPLVEPLSIDEAYLDVTDYvrlFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIA--SDLNKPN--GL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 163 VnLMDSQRQQKLLKLAPVGEVWGVGRKLSSQLETLGIKTAFDLASADPRHIGRMFSKVLERTARELRGEqwlkmhdDPDP 242
Cdd:cd03586 157 T-VIPPEDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGI-------DNRP 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 243 ------KKEIVSSKMFGRRVYLLEELRQAVAAYTTRAAEKLREQDSVCSELVVSVQTSPFadpaeRYWNGARMlLPTPTA 316
Cdd:cd03586 229 vepdreRKSIGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADF-----STRTRSRT-LPEPTD 302
|
330
....*....|....*....
gi 498492145 317 DTRDLIQAANQGLHGIYRD 335
Cdd:cd03586 303 DAEDIYELALELLEELLDG 321
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
7-149 |
1.08e-39 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 138.86 E-value: 1.08e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 7 VDCNSFYCSCERIFRPDLAQKAVVVLSNN-DACIIARSREAKALGLKMGDPYFKVKRFLDQrgVTAFSSNYALYADVSNR 85
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGGNgRGIVAAASYEARKYGVRSGMPVFEAKKLCPN--LIVVPPDLELYRRASRK 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 498492145 86 VMRTISTLVA-SIEVYSVDECWCDLTGMP---GDLEQLGRDIQARVRQWVNIPVGVGIGPTKTLAKLA 149
Cdd:pfam00817 79 IFEILRRFSTpKVEQASIDEAFLDLTGLEklfGAEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLA 146
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
3-402 |
1.05e-38 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 143.99 E-value: 1.05e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 3 VFALVDCNSFYCSCERIFRPDLAQKAVVVL---SNNDACIIARSREAKALGLKMGDPYFKVKRFLDQrGVTaFSSNYALY 79
Cdd:PRK03103 4 VILLVDMQSFYASVEKAANPELKGRPVIVSgdpERRSGVVLAACPLAKAYGVKTAERLWEAQQKCPD-LVV-VKPRMQRY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 80 ADVSNRVMRTISTLVASIEVYSVDECWCDLTG---MPGDLEQLGRDIQARVRQWVNIPVGVGIGPTKTLAKLA--QWAGK 154
Cdd:PRK03103 82 IDVSLQITRILEDFTDLVEPFSIDEQFLDVTGsqkLFGSPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMAcdNFAKK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 155 NwpaTGGVVNLMDSQRQQKLLKLaPVGEVWGVGRKLSSQLETLGIKTAFDLASADPRHIGRMF---SKVLERTARELrge 231
Cdd:PRK03103 162 N---PDGLFTLDKEDVPADLWPL-PVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWginGEVLWRTANGI--- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 232 qwlkmhdDPDPkkeiVSSKMFGR--------------------RVYLLeELRQAVAAyttRAaeklREQDSVCSELVVSV 291
Cdd:PRK03103 235 -------DYSP----VTPHSLDRqkaighqmtlprdyrgfeeiKVVLL-ELCEEVCR---RA----RAKGYMGRTVSVSL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 292 QTSPFADPAERywnGARMLLPTPTADTRDLIQAANQGLHGIYrDGFAYSKCTIQLCRLSQLEGLTHDMFAPQPRRnvDSL 371
Cdd:PRK03103 296 RGADFDWPTGF---SRQMTLPEPTNLAMEVYEAACKLFHRHW-DGKPVRRVGVTLSNLVSDDVWQLSLFGDRERK--RSL 369
|
410 420 430
....*....|....*....|....*....|.
gi 498492145 372 MATMDLVNERFGRGALRVASIPVEAGWAMRR 402
Cdd:PRK03103 370 GYVMDDIKNRFGPTAILRASSLTEAGQAFER 400
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
7-388 |
8.33e-29 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 116.67 E-value: 8.33e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 7 VDCNSFYCSCERIFRPDLAQKAVVVLSN---NDACIIARSREAKALGLKMGDPYFKVKRFLDQRGVTafSSNYALYADVS 83
Cdd:PRK01810 10 VDMNSFFASVEIAYDPSLQGKPLAVAGNekeRKGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVR--RPNFDRYREAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 84 NRVMRTISTLVASIEVYSVDECWCDLTGMP--GDLEQLGRDIQARVRQWVNIPVGVGIGPTKTLAKLAQwagkNWPATGG 161
Cdd:PRK01810 88 RQMFQILSEFTPLVQPVSIDEGYLDITDCYalGSPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMAS----DMKKPLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 162 VVNLMDSQRQQKLLKLaPVGEVWGVGRKLSSQLETLGIKTAFDLASADPRHIGRMFSKVLERTARELRGeqwlkMHDDP- 240
Cdd:PRK01810 164 ITVLRKRDVPEMLWPL-PVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANG-----IDDRPv 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 241 DPK-----KEIVSSKMFGRRVYLLEELRQAVAAYTTRAAEKLREQDSVCSELVVSVQTSPFAdpaerywNGAR-MLLPTP 314
Cdd:PRK01810 238 DPEaiyqfKSVGNSTTLSHDMDEEKELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRR-------TITRsKTLKNP 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 315 TADTRDLIQAANQ-----------GLHGIY-RDGFAYSKCTIQLcrlsqleglthDMFAPQPRRNVDSLMATMDLVNERF 382
Cdd:PRK01810 311 IWEKRDIFQAASRlfkqhwngdpvRLLGVTaTDLEWKTEAVKQL-----------DLFSFEEDAKEEPLLAVIDQINDKY 379
|
....*.
gi 498492145 383 GRGALR 388
Cdd:PRK01810 380 GMPLLQ 385
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
8-402 |
3.63e-26 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 108.92 E-value: 3.63e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 8 DCNSFYCSCERIFRPDLAQKAVVVlsnNDACIIARSREAKALGLKMGDPYFKVKRFLDQRGVTAfsSNYALYADVSNRVM 87
Cdd:PRK03858 10 DLDSFYASVEQRDDPALRGRPVIV---GGGVVLAASYEAKAYGVRTAMGGRQARRLCPQAVVVP--PRMSAYSRASKAVF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 88 RTISTLVASIEVYSVDECWCDLTGM---PGDLEQLGRDIQARVRQWVNIPVGVGIGPTKTLAKLAQWAGKnwpaTGGVVn 164
Cdd:PRK03858 85 EVFRDTTPLVEGLSIDEAFLDVGGLrriSGTPVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAK----PDGLL- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 165 LMDSQRQQKLLKLAPVGEVWGVGRKLSSQLETLGIKTAFDLASADPRHIGRMfskvLERTArelrGEQW--LKMHDDPDP 242
Cdd:PRK03858 160 VVPPDRELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAELPESALVSL----LGPAA----GRHLhaLAHNRDPRR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 243 ------KKEIVSSKMFGRRVYLLEELRQAVAAYTTRAAEKLREQDSVCSELVVSVQtspFADpaerYWNGARML-LPTPT 315
Cdd:PRK03858 232 vetgrrRRSVGAQRALGRGPNSPAEVDAVVVALVDRVARRMRAAGRTGRTVVLRLR---FDD----FTRATRSHtLPRPT 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 316 ADTRDLIQAANQGLHG----IYRDG---FAYSKCTIQLCRLSQLEgLTHDmfapqPRRNVDSLMATMDLVNERFGRGAL- 387
Cdd:PRK03858 305 ASTATLLAAARDLVAAaaplIAERGltlVGFAVSNLDDDGAQQLE-LPFG-----LRRPGSALDAALDAVRDRFGNAAVt 378
|
410
....*....|....*
gi 498492145 388 RVASIPVEAGWAMRR 402
Cdd:PRK03858 379 RAVLLGRDPGLEVPM 393
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
7-325 |
1.91e-25 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 105.87 E-value: 1.91e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 7 VDCNSFYCSCERIFRPDLAQKAVVVLSNND-----ACIIARSREAKALGLKMGDPYFKVKR------FLdqrgvtafSSN 75
Cdd:PRK03352 10 VDLDQFIAAVELLRRPELAGLPVIVGGNGDpteprKVVTCASYEARAFGVRAGMPLRTAARrcpdavFL--------PSD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 76 YALYADVSNRVMRTISTLVASIEVYSVDECWcdLTGMPGDLEQLGRDIQARVRQWVNIPVGVGIGPTKTLAKLAQWAGK- 154
Cdd:PRK03352 82 PAAYDAASEEVMATLRDLGVPVEVWGWDEAF--LGVDTDDPEALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAKp 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 155 ---------NWPATGGvvnlmdsQRqqkllklaPVGEVWGVGRKLSSQLETLGIKTAFDLASADPRHIGRMFSKVLERTA 225
Cdd:PRK03352 160 agvfrltdaNWMAVMG-------DR--------PTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGPTTGPWL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 226 REL-RGEQWLKMHDDPDPKKEIVSSKMFGRRVYLLEELRQAVAAYTTRAAEKLREQDSVCSELVVSVQTSPFADPAEryw 304
Cdd:PRK03352 225 LLLaRGGGDTEVSAEPWVPRSRSREVTFPQDLTDRAEVESAVRELARRVLDEVVAEGRPVTRVAVKVRTATFYTRTK--- 301
|
330 340
....*....|....*....|.
gi 498492145 305 ngARMlLPTPTADTRDLIQAA 325
Cdd:PRK03352 302 --IRK-LPEPTTDPDVIEAAA 319
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
5-402 |
3.36e-23 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 100.78 E-value: 3.36e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 5 ALVDCNSFYCSCERIFRPDLAQKAVV-------VLSNndACIIARSReakalGLKMGDPYFKVKRFLDQRGVTAfsSNYA 77
Cdd:PRK02794 39 AHIDCDAFYASVEKRDNPELRDKPVIigggkrgVVST--ACYIARIH-----GVRSAMPMFKALKLCPDAVVIK--PDME 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 78 LYADVSNRVMRTISTLVASIEVYSVDECWCDLTG------MPGDLeQLGRdIQARVRQWVNIPVGVGIGPTKTLAKLAQW 151
Cdd:PRK02794 110 KYVRVGREVRAMMQALTPLVEPLSIDEAFLDLSGterlhgAPPAV-VLAR-FARRVEREIGITVSVGLSYNKFLAKIASD 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 152 AGKnwPATGGVVnlmDSQRQQKLLKLAPVGEVWGVGRKLSSQLETLGIKTAFDLASADPRHIGRMFSKVLERTARELRGE 231
Cdd:PRK02794 188 LDK--PRGFSVI---GRAEALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLARGI 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 232 QWLKMHDDpDPKKEIVSSKMFGRRVYLLEELRQAVAAYTTRAAEKLREQDSVCSELVVSVQTSPFADPAERywngARMLL 311
Cdd:PRK02794 263 DDRKVSPD-REAKSVSAETTFETDLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLRTRR----RTLED 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 312 PTPTADT-----RDLIQAAnqglhgiyRDGFAYSKCTIQLCRLS-QLEGLTHDMFAPQPRRNVDSlMATMDLVNERFGRG 385
Cdd:PRK02794 338 PTQLADRifrtaRELLEKE--------TDGTAFRLIGIGVSDLSpADEADPPDLLDPQATRRAAA-ERAIDALRAKFGAA 408
|
410
....*....|....*..
gi 498492145 386 AlrvasipVEAGWAMRR 402
Cdd:PRK02794 409 A-------VETGRALRG 418
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
6-275 |
1.25e-21 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 95.24 E-value: 1.25e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 6 LVDCNSFYCSCERIFRPDLAQKAVVVL----SNNDACIIARSR-EAKALGLKMGDPYFKVKR------FLDQRGvtafss 74
Cdd:PRK01216 5 FVDFDYFFAQVEEVLNPSLKGKPVVVCvysgRFEDSGAVATANyEARKLGIKAGMPIVEAKKilpnavYLPMRK------ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 75 nyALYADVSNRVMRTISTLVASIEVYSVDECWCDLTGMPGDLE---QLGRDIQARVRQWVNIPVGVGIGPTKTLAKLAqw 151
Cdd:PRK01216 79 --EVYQQVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKNYQdayNLGLEIKNKILEKEKITVTVGISKNKVFAKIA-- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 152 AGKNWPATGGVVnlmDSQRQQKLLKLAPVGEVWGVGRKLSSQLETLGIKTAFDLASAD----PRHIGRMFSKVLERTARE 227
Cdd:PRK01216 155 ADMAKPNGIKVI---DDEEVKRFINELDIADIPGIGDITAEKLKKLGVNKLVDTLRIEfdelKGIIGEAKAKYLFSLARN 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 498492145 228 lrgeqwlkMHDDPDPKKEIVSskmFGRRVYLLEELR--QAVAAYTTRAAE 275
Cdd:PRK01216 232 --------EYNEPVRARVRKS---IGRYVTLPRNTRdlEEIKPYLKRAIE 270
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
7-325 |
9.59e-21 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 93.85 E-value: 9.59e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 7 VDCNSFYCSCERIFRPDLAQKAVVVLSNNDACIIA-RSREAKALGLKMGDPYFKVKRFLDQRGVTaFSSNYALYADVSNR 85
Cdd:PRK03348 10 LDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAgASYEARVFGARSAMPMHQARRLVGNGAVV-LPPRFVVYRAASRR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 86 VMRTISTLVASIEVYSVDECWCDLTGMPG----DLEQLGRDIQARVRQWVNIPVGVGIGPTKTLAKLAQWAGKnwPatGG 161
Cdd:PRK03348 89 VFDTLRELSPVVEQLSFDEAFVEPAELAGasaeEVEAFAERLRARVREETGLPASVGAGSGKQIAKIASGLAK--P--DG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 162 VVnLMDSQRQQKLLKLAPVGEVWGVGRKLSSQLETLGIKTAFDLASADPRHIGRMFSKV----LERTARElrgeqwlkmH 237
Cdd:PRK03348 165 IR-VVPPGEERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEVANLLGATvgpaLHRLARG---------I 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 238 DD----PD-PKKEIVSSKMFGRRVYLLEELRQAVAAYTTRAAEKLREQDSVCSELVVSVQTSPFadpaerywngaRML-- 310
Cdd:PRK03348 235 DDrpvaERaEAKQISAESTFAVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDF-----------STLtr 303
|
330
....*....|....*...
gi 498492145 311 ---LPTPTADTRDLIQAA 325
Cdd:PRK03348 304 satLPYATDDAAVLAATA 321
|
|
| DUF4113 |
pfam13438 |
Domain of unknown function (DUF4113); Although the function is not known this domain occurs ... |
371-419 |
4.32e-20 |
|
Domain of unknown function (DUF4113); Although the function is not known this domain occurs almost invariably at the very C-terminus of the IMS family DNA-polymerase repair proteins, IMS, pfam00817.
Pssm-ID: 463876 [Multi-domain] Cd Length: 49 Bit Score: 82.92 E-value: 4.32e-20
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 498492145 371 LMATMDLVNERFGRGALRVASIPVEAGWAMRREMLSPSYTTSWRELPRA 419
Cdd:pfam13438 1 LMAALDAINRRYGRGTVRLAAQGLKRDWKMRREHLSPRYTTRWDELPVV 49
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
7-297 |
2.00e-16 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 80.15 E-value: 2.00e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 7 VDCNSFYCSCERIFRPDLAQKAVVVLSNNDACIIAR-SREAKALGLKMGDPYFKVKRFLDQrGVTaFSSNYALYADVSNR 85
Cdd:PRK14133 8 VDMDAFFASVEQMDNPKLKGKPVIVGGISERGVVSTcSYEARKYGVHSAMPVFMAKKRCPH-GIF-LPVRHERYKEVSKN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 86 VMRTISTLVASIEVYSVDECWCDLTGMPGDLEQLGRDIQARVRQWVNIPVGVGIGPTKTLAKLAQwagkNWPATGGvVNL 165
Cdd:PRK14133 86 IFKILYEVTPIVEPVSIDEAYLDITNIKEEPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLAS----DWNKPDG-IKI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 166 MDSQRQQKLLKLAPVGEVWGVGRKLSSQLETLGIKTAFDLASADPRHIGRMFSKVLERTARELRGEqwlkmhdDPDPKKE 245
Cdd:PRK14133 161 ITEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEYFGKFGVEIYERIRGI-------DYREVEV 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 498492145 246 IVSSKMFGRRVYL------LEELRQAVAAYTTRAAEKLREQDSVCSELVVSVQTSPFA 297
Cdd:PRK14133 234 SRERKSIGKETTLkkdtkdKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQ 291
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
2-201 |
4.62e-16 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 79.28 E-value: 4.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 2 SVFALVDCNSFYCSCERIFRPDLAQKAVVVLS--NNDACIIARSREAKALGLKMGDPYFKVKRFLDQrgVTAFSSNYALY 79
Cdd:cd01701 47 RIIMHVDFDCFFVSVSIRNRPDLKGKPVAVCHgkGPNSEIASCNYEARSYGIKNGMWVGQAKKLCPQ--LVTLPYDFEAY 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 80 ADVSNRVMRTISTLVASIEVYSVDECWCDLTGMPG----DLEQLGRDIQARVRQWVNIPVGVGIGPTKTLAKLAQWAGKn 155
Cdd:cd01701 125 EEVSLTFYEILASYTDNIEAVSCDEALIDITSLLEetyeLPEELAEAIRNEIRETTGCSASVGIGPNILLARLATRKAK- 203
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 498492145 156 wPAtgGVVNLMDSQRQQKLLKLaPVGEVWGVGRKLSSQLETLGIKT 201
Cdd:cd01701 204 -PD--GQYHLSAEKVEEFLSQL-KVGDLPGVGSSLAEKLVKLFGDT 245
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
243-350 |
6.98e-16 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 72.98 E-value: 6.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 243 KKEIVSSKMFGRRVYLLEELRQAVAAYTTRAAEKLREQDSVCSELVVSVQTSPFadpaeRYWNGARMlLPTPTADTRDLI 322
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDF-----RTITRSVT-LPSPTDDTDEIY 74
|
90 100
....*....|....*....|....*...
gi 498492145 323 QAANQGLHGIYRdGFAYSKCTIQLCRLS 350
Cdd:pfam11799 75 RAALRLLRRLYR-GRPVRLLGVSLSNLV 101
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
5-256 |
1.39e-08 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 56.17 E-value: 1.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 5 ALVDCNSFYCSCERIFRPDLAQKAVVVLSNNDacIIARSREAKALGL------------------------KMGDPYFKV 60
Cdd:cd01702 1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNS--IIAVSYAARAFGVtrfmtideakkkcpdlilahvatyKKGEDEADY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 61 KRFLDQ-RGVTAFSsnyaLYADVSNRVMRTISTLVASIEVYSVDECWCDltgmpgdleqLGRDIQARVRQWVNIPVG--- 136
Cdd:cd01702 79 HENPSPaRHKVSLD----PYRRASRKILNILKRFGDVVEKASIDEAYLD----------LGSRIVEEIRQQVYDELGytc 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 137 -VGIGPTKTLAKLAqwAGKNWPA--TggvvnLMDSQRQQKLLKLAPVGEVWGVGRKL-SSQLETLGIKTAFDLAS--ADP 210
Cdd:cd01702 145 sAGIAHNKMLAKLA--SGMNKPNaqT-----ILRNDAVASFLSSLPITSIRGLGGKLgEEIIDLLGLPTEGDVAGfrSSE 217
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 498492145 211 RHIGRMFSkvlERTAREL----RGEQWLKMHDDPDPkKEIVSSKMFGRRV 256
Cdd:cd01702 218 SDLQEHFG---EKLGEWLynllRGIDHEPVKPRPLP-KSMGSSKNFPGKT 263
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
6-223 |
3.53e-06 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 48.62 E-value: 3.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 6 LVDCNSFYCSCERIFRPDLA-------QKAVVVLSNndaciiarsREAKALGLKmgdpyfKVKRFLDQRG-----VTAFS 73
Cdd:cd01703 2 HLDLDCFYAQVEEIRDPSLKskplgiqQKYIVVTCN---------YEARRLGVK------KLMSIKDAKEicpdlVLVNG 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 74 SNYALYADVSNRVMRTISTLVAS--IEVYSVDECWCDLTGMPgdlEQLGRDIQARVRQWVNIPVGV----GIGPTKTLAK 147
Cdd:cd01703 67 EDLTPFRDMSKKVYRLLRSYSWNdrVERLGFDENFMDVTEMR---LLVASHIAYEMRERIENELGLtccaGIASNKLLAK 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 148 LAqwAGKNWPatggvvnlmdsqRQQKLLkLAPVGE-------------VWGVGRKLSSQLETLGIKTAFDLASAD--PRH 212
Cdd:cd01703 144 LV--GSVNKP------------NQQTTL-LPPSCAdlmdfmdlhdlrkIPGIGYKTAAKLEAHGISSVRDLQEFSnrNRQ 208
|
250
....*....|.
gi 498492145 213 IGRMFSKVLER 223
Cdd:cd01703 209 TVGAAPSLLEL 219
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
16-289 |
1.76e-05 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 46.61 E-value: 1.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 16 CERIFRPDLAQKAVVVLSNNDACIIARSREAKALGLKMGDPyfKVKRFLDQRGVTAFSSNYALYADVSNRVMRTISTLVA 95
Cdd:cd03468 13 LLRNRPADDEAPLAVVERKKAGRILACNAAARAAGVRPGMP--LAEALALCPNLQVVEYDPEADARALQELALWLLRFTP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 96 SIEVYSVDECWCDLTGM----PGDLEQLGRDIQARVRQwvNIPVGVGIGPTKTLAKLAQWAGKNwpatGGVVNLMDSQRQ 171
Cdd:cd03468 91 LVALDGPDGLLLDVTGClhlfGGEDALAASLRAALATL--GLSARAGIADTPGAAWLLARAGGG----RGVLRREALAAA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492145 172 QKLLKLAPVGEVwGVGRKLSSQLETLGIKTAFDLASADPRHIGRMFSKVLERTARELRGEQWLKMHDDPDPKKEIVSSkm 251
Cdd:cd03468 165 LVLLAPLPVAAL-RLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQAYGRDPEPLLFSPPPPAFDFRL-- 241
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 498492145 252 fgRRVYLLE---ELRQAVAAYTTRAAEKLREQDSVCSELVV 289
Cdd:cd03468 242 --ELQLEEPiarGLLFPLRRLLEQLCAFLALRGLGARRLSL 280
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
179-199 |
1.07e-03 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 36.22 E-value: 1.07e-03
|
| Castor_Poll_mid |
pfam06241 |
Castor and Pollux, part of voltage-gated ion channel; This family represents a short region in ... |
318-356 |
1.93e-03 |
|
Castor and Pollux, part of voltage-gated ion channel; This family represents a short region in the middle of largely plant proteins that belong to the TCDB:1.A.1.23.2 family of the voltage-gated ion channel superfamily, eg UniProtKB:Q5H8A6, Q5H8A5 and Q4VY51.
Pssm-ID: 428842 [Multi-domain] Cd Length: 99 Bit Score: 37.34 E-value: 1.93e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 498492145 318 TRDLIQAANQ-GLHGIYRDGFAYSKCTIQLCRLSQLEGLT 356
Cdd:pfam06241 5 SRLFVQCSRQkGLAKIYRDLLNFRKNEFYLKSWPQLQGMT 44
|
|
| |
