|
Name |
Accession |
Description |
Interval |
E-value |
| COG4889 super family |
cl34837 |
Predicted helicase [General function prediction only]; |
7-429 |
1.88e-66 |
|
Predicted helicase [General function prediction only];
The actual alignment was detected with superfamily member COG4889:
Pssm-ID: 443917 [Multi-domain] Cd Length: 1571 Bit Score: 242.94 E-value: 1.88e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 7 SLAEHQHEGLNGTLQVFQRGNRAQVHMACGTGKT----RLGQAVAFATeadcvlvllpslSLI----------SQTLAAW 72
Cdd:COG4889 169 TLRPHQQEAIEAVLAGFKTHDRGKLIMACGTGKTftslRIAEELAGKG------------GRVlflvpsisllSQTLREW 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 73 ISLGRLPLdRILCVCSDPSV---AESEDEDVGIVDLPVEVTTDP--LAIETFVERRSTGPLYVFCTYHSVPTLA----AG 143
Cdd:COG4889 237 TAESEVPL-RSFAVCSDSKVgkrRKKDDEDTSAHDLAYPATTDAekLAAAAQKRHDADRMTVVFSTYQSIDVVAdaqkLG 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 144 LPVgflFDLGIFDEAHRTAGYVDAG-----FTfALHDHSTLKIGKRLFLTATPKHLPETARA-----GFEVYSMCNEEVY 213
Cdd:COG4889 316 LPE---FDLIICDEAHRTTGATLAGedesaFV-RVHDNDYIKAKKRLYMTATPRIYGDDAKKkakeaSAVLASMDDEALF 391
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 214 GPVAYHLSMQEAIARGIICDFQVIITVV-------------GDSGPELR--DAYEVVeedwaGA-NA-TIHAVELVRAMQ 276
Cdd:COG4889 392 GPEFHRLGFGEAVERGLLTDYKVIVLAVdeshvsrrlqqllADNGNELKldDAAKIV-----GCwNGlAKRGGEEDGTDD 466
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 277 QVGARKAFTFHNFISQSRLFSDTLNKV-------------GDRLAPGIQGWHVDGRMAGSERHLILR------QFIECDm 337
Cdd:COG4889 467 PAPMKRAVAFCQTIKESKRIAEHFVSVvniylmfqddeaeEDAPSLRCEAEHVDGTMNALERNEKLDwlkaetPENTCR- 545
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 338 gVVSNARCLSEGTDAPVVDMVGFLDPKESSTDIVQALGRALRRAPGKLKGYVLLPVRLKLghGETAQQALARS-SMKHIW 416
Cdd:COG4889 546 -ILSNARCLSEGVDVPALDAVLFLTPRKSQVDVVQSVGRVMRKAPGKKYGYIILPVVIPA--GVEPEEALDDNeTYKVVW 622
|
490
....*....|...
gi 498492012 417 RVLSTVAELDDRI 429
Cdd:COG4889 623 QVLNALRSHDDRF 635
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
483-545 |
3.25e-18 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
:
Pssm-ID: 427308 Cd Length: 63 Bit Score: 79.20 E-value: 3.25e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498492012 483 VSWETSFGHLQRYLEEFGHCAVPkRYVTASGSRLGLWCAQQRTLHAQGVLADDRRVQLEAIGF 545
Cdd:pfam03457 2 EAWEERYEALKAYKAEHGHLNVP-RYVTEEGFKLGRWVANQRRKYRKGKLTAERIERLEALGF 63
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
552-614 |
3.44e-17 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
:
Pssm-ID: 427308 Cd Length: 63 Bit Score: 76.50 E-value: 3.44e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498492012 552 TSWADAFQELRRYKRDQGHANVPAgHVTETGRNLGTWCSEQRKAYRAGRLSDSREEQLRSEGF 614
Cdd:pfam03457 2 EAWEERYEALKAYKAEHGHLNVPR-YVTEEGFKLGRWVANQRRKYRKGKLTAERIERLEALGF 63
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
686-749 |
8.10e-14 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
:
Pssm-ID: 427308 Cd Length: 63 Bit Score: 66.87 E-value: 8.10e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 498492012 686 DSSWEDGFEALLEYFE---DTLSPSppleYESPGGFALGTWVSYQRQRYQAGKLELNRISRLERLGF 749
Cdd:pfam03457 1 EEAWEERYEALKAYKAehgHLNVPR----YVTEEGFKLGRWVANQRRKYRKGKLTAERIERLEALGF 63
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
755-817 |
5.24e-12 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
:
Pssm-ID: 427308 Cd Length: 63 Bit Score: 61.48 E-value: 5.24e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498492012 755 SAAFEDGLLQLRLFQSTHGHCDVPtTYVTAAGYKLGSWCSNQRTRLKSR--PEDpRAKALIDLGF 817
Cdd:pfam03457 1 EEAWEERYEALKAYKAEHGHLNVP-RYVTEEGFKLGRWVANQRRKYRKGklTAE-RIERLEALGF 63
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
620-679 |
2.95e-11 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
:
Pssm-ID: 427308 Cd Length: 63 Bit Score: 59.55 E-value: 2.95e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 498492012 620 EDLWEENFKALQAFIEQNGHSNIPETVEGSrGIKLADWLRNQRTRR----ITLARKRRLEGVGV 679
Cdd:pfam03457 1 EEAWEERYEALKAYKAEHGHLNVPRYVTEE-GFKLGRWVANQRRKYrkgkLTAERIERLEALGF 63
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
824-881 |
4.25e-09 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
:
Pssm-ID: 427308 Cd Length: 63 Bit Score: 53.39 E-value: 4.25e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 498492012 824 AAWEKHYTLAAAYVAEHGSMP-STYQAPSGEKVGAWLYRQQQKLKKGTLPEVQARLLAD 881
Cdd:pfam03457 2 EAWEERYEALKAYKAEHGHLNvPRYVTEEGFKLGRWVANQRRKYRKGKLTAERIERLEA 60
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| COG4889 |
COG4889 |
Predicted helicase [General function prediction only]; |
7-429 |
1.88e-66 |
|
Predicted helicase [General function prediction only];
Pssm-ID: 443917 [Multi-domain] Cd Length: 1571 Bit Score: 242.94 E-value: 1.88e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 7 SLAEHQHEGLNGTLQVFQRGNRAQVHMACGTGKT----RLGQAVAFATeadcvlvllpslSLI----------SQTLAAW 72
Cdd:COG4889 169 TLRPHQQEAIEAVLAGFKTHDRGKLIMACGTGKTftslRIAEELAGKG------------GRVlflvpsisllSQTLREW 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 73 ISLGRLPLdRILCVCSDPSV---AESEDEDVGIVDLPVEVTTDP--LAIETFVERRSTGPLYVFCTYHSVPTLA----AG 143
Cdd:COG4889 237 TAESEVPL-RSFAVCSDSKVgkrRKKDDEDTSAHDLAYPATTDAekLAAAAQKRHDADRMTVVFSTYQSIDVVAdaqkLG 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 144 LPVgflFDLGIFDEAHRTAGYVDAG-----FTfALHDHSTLKIGKRLFLTATPKHLPETARA-----GFEVYSMCNEEVY 213
Cdd:COG4889 316 LPE---FDLIICDEAHRTTGATLAGedesaFV-RVHDNDYIKAKKRLYMTATPRIYGDDAKKkakeaSAVLASMDDEALF 391
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 214 GPVAYHLSMQEAIARGIICDFQVIITVV-------------GDSGPELR--DAYEVVeedwaGA-NA-TIHAVELVRAMQ 276
Cdd:COG4889 392 GPEFHRLGFGEAVERGLLTDYKVIVLAVdeshvsrrlqqllADNGNELKldDAAKIV-----GCwNGlAKRGGEEDGTDD 466
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 277 QVGARKAFTFHNFISQSRLFSDTLNKV-------------GDRLAPGIQGWHVDGRMAGSERHLILR------QFIECDm 337
Cdd:COG4889 467 PAPMKRAVAFCQTIKESKRIAEHFVSVvniylmfqddeaeEDAPSLRCEAEHVDGTMNALERNEKLDwlkaetPENTCR- 545
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 338 gVVSNARCLSEGTDAPVVDMVGFLDPKESSTDIVQALGRALRRAPGKLKGYVLLPVRLKLghGETAQQALARS-SMKHIW 416
Cdd:COG4889 546 -ILSNARCLSEGVDVPALDAVLFLTPRKSQVDVVQSVGRVMRKAPGKKYGYIILPVVIPA--GVEPEEALDDNeTYKVVW 622
|
490
....*....|...
gi 498492012 417 RVLSTVAELDDRI 429
Cdd:COG4889 623 QVLNALRSHDDRF 635
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
483-545 |
3.25e-18 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
Pssm-ID: 427308 Cd Length: 63 Bit Score: 79.20 E-value: 3.25e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498492012 483 VSWETSFGHLQRYLEEFGHCAVPkRYVTASGSRLGLWCAQQRTLHAQGVLADDRRVQLEAIGF 545
Cdd:pfam03457 2 EAWEERYEALKAYKAEHGHLNVP-RYVTEEGFKLGRWVANQRRKYRKGKLTAERIERLEALGF 63
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
552-614 |
3.44e-17 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
Pssm-ID: 427308 Cd Length: 63 Bit Score: 76.50 E-value: 3.44e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498492012 552 TSWADAFQELRRYKRDQGHANVPAgHVTETGRNLGTWCSEQRKAYRAGRLSDSREEQLRSEGF 614
Cdd:pfam03457 2 EAWEERYEALKAYKAEHGHLNVPR-YVTEEGFKLGRWVANQRRKYRKGKLTAERIERLEALGF 63
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
686-749 |
8.10e-14 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
Pssm-ID: 427308 Cd Length: 63 Bit Score: 66.87 E-value: 8.10e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 498492012 686 DSSWEDGFEALLEYFE---DTLSPSppleYESPGGFALGTWVSYQRQRYQAGKLELNRISRLERLGF 749
Cdd:pfam03457 1 EEAWEERYEALKAYKAehgHLNVPR----YVTEEGFKLGRWVANQRRKYRKGKLTAERIERLEALGF 63
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
755-817 |
5.24e-12 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
Pssm-ID: 427308 Cd Length: 63 Bit Score: 61.48 E-value: 5.24e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498492012 755 SAAFEDGLLQLRLFQSTHGHCDVPtTYVTAAGYKLGSWCSNQRTRLKSR--PEDpRAKALIDLGF 817
Cdd:pfam03457 1 EEAWEERYEALKAYKAEHGHLNVP-RYVTEEGFKLGRWVANQRRKYRKGklTAE-RIERLEALGF 63
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
620-679 |
2.95e-11 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
Pssm-ID: 427308 Cd Length: 63 Bit Score: 59.55 E-value: 2.95e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 498492012 620 EDLWEENFKALQAFIEQNGHSNIPETVEGSrGIKLADWLRNQRTRR----ITLARKRRLEGVGV 679
Cdd:pfam03457 1 EEAWEERYEALKAYKAEHGHLNVPRYVTEE-GFKLGRWVANQRRKYrkgkLTAERIERLEALGF 63
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
824-881 |
4.25e-09 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
Pssm-ID: 427308 Cd Length: 63 Bit Score: 53.39 E-value: 4.25e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 498492012 824 AAWEKHYTLAAAYVAEHGSMP-STYQAPSGEKVGAWLYRQQQKLKKGTLPEVQARLLAD 881
Cdd:pfam03457 2 EAWEERYEALKAYKAEHGHLNvPRYVTEEGFKLGRWVANQRRKYRKGKLTAERIERLEA 60
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
333-393 |
9.30e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 50.01 E-value: 9.30e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 498492012 333 IECDMGVVSNARCLSEGTDAPVVDMVGFLDPKESSTDIVQALGRALRraPGKLKGYVLLPV 393
Cdd:cd18785 19 IASSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGR--GGKDEGEVILFV 77
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
315-379 |
2.59e-06 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 46.82 E-value: 2.59e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498492012 315 HVDGRMAGSERHLILRQFIECDMGVVSNARCLSEGTDAPVVDMVGFLDPKESSTDIVQALGRALR 379
Cdd:pfam00271 43 RLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGR 107
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
316-380 |
4.88e-06 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 45.28 E-value: 4.88e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498492012 316 VDGRMAGSERHLILRQFIECDMGVVSNARCLSEGTDAPVVDMVGFLDPKESSTDIVQALGRALRR 380
Cdd:smart00490 17 LHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRA 81
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| COG4889 |
COG4889 |
Predicted helicase [General function prediction only]; |
7-429 |
1.88e-66 |
|
Predicted helicase [General function prediction only];
Pssm-ID: 443917 [Multi-domain] Cd Length: 1571 Bit Score: 242.94 E-value: 1.88e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 7 SLAEHQHEGLNGTLQVFQRGNRAQVHMACGTGKT----RLGQAVAFATeadcvlvllpslSLI----------SQTLAAW 72
Cdd:COG4889 169 TLRPHQQEAIEAVLAGFKTHDRGKLIMACGTGKTftslRIAEELAGKG------------GRVlflvpsisllSQTLREW 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 73 ISLGRLPLdRILCVCSDPSV---AESEDEDVGIVDLPVEVTTDP--LAIETFVERRSTGPLYVFCTYHSVPTLA----AG 143
Cdd:COG4889 237 TAESEVPL-RSFAVCSDSKVgkrRKKDDEDTSAHDLAYPATTDAekLAAAAQKRHDADRMTVVFSTYQSIDVVAdaqkLG 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 144 LPVgflFDLGIFDEAHRTAGYVDAG-----FTfALHDHSTLKIGKRLFLTATPKHLPETARA-----GFEVYSMCNEEVY 213
Cdd:COG4889 316 LPE---FDLIICDEAHRTTGATLAGedesaFV-RVHDNDYIKAKKRLYMTATPRIYGDDAKKkakeaSAVLASMDDEALF 391
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 214 GPVAYHLSMQEAIARGIICDFQVIITVV-------------GDSGPELR--DAYEVVeedwaGA-NA-TIHAVELVRAMQ 276
Cdd:COG4889 392 GPEFHRLGFGEAVERGLLTDYKVIVLAVdeshvsrrlqqllADNGNELKldDAAKIV-----GCwNGlAKRGGEEDGTDD 466
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 277 QVGARKAFTFHNFISQSRLFSDTLNKV-------------GDRLAPGIQGWHVDGRMAGSERHLILR------QFIECDm 337
Cdd:COG4889 467 PAPMKRAVAFCQTIKESKRIAEHFVSVvniylmfqddeaeEDAPSLRCEAEHVDGTMNALERNEKLDwlkaetPENTCR- 545
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 338 gVVSNARCLSEGTDAPVVDMVGFLDPKESSTDIVQALGRALRRAPGKLKGYVLLPVRLKLghGETAQQALARS-SMKHIW 416
Cdd:COG4889 546 -ILSNARCLSEGVDVPALDAVLFLTPRKSQVDVVQSVGRVMRKAPGKKYGYIILPVVIPA--GVEPEEALDDNeTYKVVW 622
|
490
....*....|...
gi 498492012 417 RVLSTVAELDDRI 429
Cdd:COG4889 623 QVLNALRSHDDRF 635
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
7-551 |
2.19e-35 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 142.47 E-value: 2.19e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 7 SLAEHQHEGLNGTLQVFQRGN-RAQVHMACGTGKTRLGQAVAFATeadcvlvllpslslisqtlaawislgrLPLDRILC 85
Cdd:COG1061 80 ELRPYQQEALEALLAALERGGgRGLVVAPTGTGKTVLALALAAEL---------------------------LRGKRVLV 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 86 VCSDPSVAESededvgIVDLPVEVTTDPLAIEtfvERRSTGPLYVFCTYHSVPTLAAGLPVGFLFDLGIFDEAHRTAgyv 165
Cdd:COG1061 133 LVPRRELLEQ------WAEELRRFLGDPLAGG---GKKDSDAPITVATYQSLARRAHLDELGDRFGLVIIDEAHHAG--- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 166 dAGFTFALHDHstLKIGKRLFLTATPKHlpetaRAGFEVYsmcnEEVYGPVAYHLSMQEAIARGIICDFQVIItvVGDSG 245
Cdd:COG1061 201 -APSYRRILEA--FPAAYRLGLTATPFR-----SDGREIL----LFLFDGIVYEYSLKEAIEDGYLAPPEYYG--IRVDL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 246 PELRDAYEVVEEDW-----AGANATIHAVELVRAmQQVGARKAFTFHNFISQSRLFSDTLNKVGDRLApgiqgwHVDGRM 320
Cdd:COG1061 267 TDERAEYDALSERLrealaADAERKDKILRELLR-EHPDDRKTLVFCSSVDHAEALAELLNEAGIRAA------VVTGDT 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 321 AGSERHLILRQFIECDMGVVSNARCLSEGTDAPVVDMVGFLDPKESSTDIVQALGRALRRAPGKLKGYVLLPVrlklGHG 400
Cdd:COG1061 340 PKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGKEDALVYDFV----GND 415
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 401 ETAQQALARssmKHIWRVLSTVAELDDRIKDELVQIRRRVDPDSWGITPVSSLLDKLEvhaPAELLEAVKEFIQHQLVDR 480
Cdd:COG1061 416 VPVLEELAK---DLRDLAGYRVEFLDEEESEELALLIAVKPALEVKGELEEELLEELE---LLEDALLLVLAELLLLELL 489
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 498492012 481 LTVSWETSFGHLQRYLEEFGHCAVPKRYVTASGSRLGLWCAQQRTLHAQGVLADDRRVQLEAIGFDFDPHA 551
Cdd:COG1061 490 ALALELLELAKAEGKAEEEEEEKELLLLLALAKLLKLLLLLLLLLLLELLELLAALLRLEELAALLLKELL 560
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
483-545 |
3.25e-18 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
Pssm-ID: 427308 Cd Length: 63 Bit Score: 79.20 E-value: 3.25e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498492012 483 VSWETSFGHLQRYLEEFGHCAVPkRYVTASGSRLGLWCAQQRTLHAQGVLADDRRVQLEAIGF 545
Cdd:pfam03457 2 EAWEERYEALKAYKAEHGHLNVP-RYVTEEGFKLGRWVANQRRKYRKGKLTAERIERLEALGF 63
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
552-614 |
3.44e-17 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
Pssm-ID: 427308 Cd Length: 63 Bit Score: 76.50 E-value: 3.44e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498492012 552 TSWADAFQELRRYKRDQGHANVPAgHVTETGRNLGTWCSEQRKAYRAGRLSDSREEQLRSEGF 614
Cdd:pfam03457 2 EAWEERYEALKAYKAEHGHLNVPR-YVTEEGFKLGRWVANQRRKYRKGKLTAERIERLEALGF 63
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
686-749 |
8.10e-14 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
Pssm-ID: 427308 Cd Length: 63 Bit Score: 66.87 E-value: 8.10e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 498492012 686 DSSWEDGFEALLEYFE---DTLSPSppleYESPGGFALGTWVSYQRQRYQAGKLELNRISRLERLGF 749
Cdd:pfam03457 1 EEAWEERYEALKAYKAehgHLNVPR----YVTEEGFKLGRWVANQRRKYRKGKLTAERIERLEALGF 63
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
755-817 |
5.24e-12 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
Pssm-ID: 427308 Cd Length: 63 Bit Score: 61.48 E-value: 5.24e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498492012 755 SAAFEDGLLQLRLFQSTHGHCDVPtTYVTAAGYKLGSWCSNQRTRLKSR--PEDpRAKALIDLGF 817
Cdd:pfam03457 1 EEAWEERYEALKAYKAEHGHLNVP-RYVTEEGFKLGRWVANQRRKYRKGklTAE-RIERLEALGF 63
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
620-679 |
2.95e-11 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
Pssm-ID: 427308 Cd Length: 63 Bit Score: 59.55 E-value: 2.95e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 498492012 620 EDLWEENFKALQAFIEQNGHSNIPETVEGSrGIKLADWLRNQRTRR----ITLARKRRLEGVGV 679
Cdd:pfam03457 1 EEAWEERYEALKAYKAEHGHLNVPRYVTEE-GFKLGRWVANQRRKYrkgkLTAERIERLEALGF 63
|
|
| HA |
pfam03457 |
Helicase associated domain; This short domain is found in multiple copies in bacterial ... |
824-881 |
4.25e-09 |
|
Helicase associated domain; This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices. The function of this domain may be to bind nucleic acid.
Pssm-ID: 427308 Cd Length: 63 Bit Score: 53.39 E-value: 4.25e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 498492012 824 AAWEKHYTLAAAYVAEHGSMP-STYQAPSGEKVGAWLYRQQQKLKKGTLPEVQARLLAD 881
Cdd:pfam03457 2 EAWEERYEALKAYKAEHGHLNvPRYVTEEGFKLGRWVANQRRKYRKGKLTAERIERLEA 60
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
333-393 |
9.30e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 50.01 E-value: 9.30e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 498492012 333 IECDMGVVSNARCLSEGTDAPVVDMVGFLDPKESSTDIVQALGRALRraPGKLKGYVLLPV 393
Cdd:cd18785 19 IASSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGR--GGKDEGEVILFV 77
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
310-390 |
5.09e-07 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 49.09 E-value: 5.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 310 GIQGWHVDGRMAGSERH---LILRQFIE--------CDMgvvsnarcLSEGTDAPVVDMVGFLDPKESSTDIVQALGRAL 378
Cdd:cd18799 30 GIDAVALNSDYSDRERGdeaLILLFFGElkppilvtVDL--------LTTGVDIPEVDNVVFLRPTESRTLFLQMLGRGL 101
|
90
....*....|..
gi 498492012 379 RRAPGKLKGYVL 390
Cdd:cd18799 102 RLHEGKDFFTIL 113
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
315-379 |
2.59e-06 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 46.82 E-value: 2.59e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498492012 315 HVDGRMAGSERHLILRQFIECDMGVVSNARCLSEGTDAPVVDMVGFLDPKESSTDIVQALGRALR 379
Cdd:pfam00271 43 RLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGR 107
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
316-380 |
4.88e-06 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 45.28 E-value: 4.88e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498492012 316 VDGRMAGSERHLILRQFIECDMGVVSNARCLSEGTDAPVVDMVGFLDPKESSTDIVQALGRALRR 380
Cdd:smart00490 17 LHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRA 81
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
8-191 |
2.73e-04 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 41.91 E-value: 2.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 8 LAEHQHEGLNGTLQvFQRGNRAQVHMACGTGKTRLGQAVAFAteadcvlvllpslslisqtlaawislgrLPLDRILCVC 87
Cdd:cd17926 1 LRPYQEEALEAWLA-HKNNRRGILVLPTGSGKTLTALALIAY----------------------------LKELRTLIVV 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 88 sdPSVAesededvgIVDLPVEvttdplAIETFVERRSTGPLY------------VFCTYHSV-PTLAAGLPVGFLFDLGI 154
Cdd:cd17926 52 --PTDA--------LLDQWKE------RFEDFLGDSSIGLIGggkkkdfddanvVVATYQSLsNLAEEEKDLFDQFGLLI 115
|
170 180 190
....*....|....*....|....*....|....*..
gi 498492012 155 FDEAHRTAGyvdAGFTfALHDHstLKIGKRLFLTATP 191
Cdd:cd17926 116 VDEAHHLPA---KTFS-EILKE--LNAKYRLGLTATP 146
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
10-193 |
9.16e-04 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 40.73 E-value: 9.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 10 EHQHEGLNGTLQVFQRGN-RAQVHMACGTGKTRlgqaVAFAteadcvlvllpslslisqtlAAWISLGRLPLDRILCVCS 88
Cdd:pfam04851 6 PYQIEAIENLLESIKNGQkRGLIVMATGSGKTL----TAAK--------------------LIARLFKKGPIKKVLFLVP 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 89 DPSVAE---SEDEDVGIVDLPV-EVTTDPLAIETFVERRstgplYVFCTYHSV--PTLAAGLPVGF-LFDLGIFDEAHRT 161
Cdd:pfam04851 62 RKDLLEqalEEFKKFLPNYVEIgEIISGDKKDESVDDNK-----IVVTTIQSLykALELASLELLPdFFDVIIIDEAHRS 136
|
170 180 190
....*....|....*....|....*....|..
gi 498492012 162 AgyvDAGFTfALHDHSTLKIgkRLFLTATPKH 193
Cdd:pfam04851 137 G---ASSYR-NILEYFKPAF--LLGLTATPER 162
|
|
| HsdR |
COG4096 |
Type I site-specific restriction endonuclease, part of a restriction-modification system ... |
12-259 |
9.24e-04 |
|
Type I site-specific restriction endonuclease, part of a restriction-modification system [Defense mechanisms];
Pssm-ID: 443272 [Multi-domain] Cd Length: 806 Bit Score: 42.91 E-value: 9.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 12 QHEGLNGTLQVFQRG-NRAQVHMACGTGKTRlgqaVAFAteadcvlvllpslslISQTL--AAWISlgrlpldRILCVCs 88
Cdd:COG4096 163 QIEAIRRVEEAIAKGqRRALLVMATGTGKTR----TAIA---------------LIYRLlkAGRAK-------RILFLA- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 89 DPSV----AESE------DEDVgivdlPVEVTTDPLAIETfvERRstgpLYvFCTYhsvPTLAAGL------------PV 146
Cdd:COG4096 216 DRNAlvdqAKNAfkpflpDLDA-----FTKLYNKSKDIDK--SAR----VY-FSTY---QTMMNRIdgeeeepgyrqfPP 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 147 GFlFDLGIFDEAHRtaG----------YVDAgftfalhdhstLKIGkrlfLTATPKhlpetaragfevysmcnEEVY--- 213
Cdd:COG4096 281 DF-FDLIIIDECHR--GiyskwraildYFDA-----------LQIG----LTATPK-----------------DTIDrnt 325
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 214 -----GPVAYHLSMQEAIARGIICDFQVI-----ITVVG---DSGPELRDAY-EVVEEDW 259
Cdd:COG4096 326 yeyfnGNPVYTYSLEQAVADGFLVPYKVIridtkFDREGiryDAGEDLSDEEgEEIELEE 385
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
267-391 |
3.01e-03 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 38.88 E-value: 3.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 267 HAVELVR----AMQQVGARKAFTFHNFISQSRLFSDTLNKVGDRLAPGIQGWHVDGR----MAGSERHLILRQFIEcdmG 338
Cdd:cd18801 13 KLEEIVKehfkKKQEGSDTRVIIFSEFRDSAEEIVNFLSKIRPGIRATRFIGQASGKsskgMSQKEQKEVIEQFRK---G 89
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 498492012 339 VVSNARCLS---EGTDAPVVDMVGFLDPKESSTDIVQALGRALRRAPGKLkgYVLL 391
Cdd:cd18801 90 GYNVLVATSigeEGLDIGEVDLIICYDASPSPIRMIQRMGRTGRKRQGRV--VVLL 143
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
8-191 |
4.10e-03 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 39.40 E-value: 4.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 8 LAEHQHEGLNgtlQVFQRGNRAQVHMACGTGKTrlgqavafateadcvlvllpslslISQTLAAWISLGRLPLDRILCVC 87
Cdd:smart00487 9 LRPYQKEAIE---ALLSGLRDVILAAPTGSGKT------------------------LAALLPALEALKRGKGGRVLVLV 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498492012 88 sdPSVA---------ESEDEDVGIVDLPVEVTTDPLAIETFVERRSTGplYVFCTYHSVPTLAAGLPVGFL-FDLGIFDE 157
Cdd:smart00487 62 --PTRElaeqwaeelKKLGPSLGLKVVGLYGGDSKREQLRKLESGKTD--ILVTTPGRLLDLLENDKLSLSnVDLVILDE 137
|
170 180 190
....*....|....*....|....*....|....
gi 498492012 158 AHRTAGYVDAGFTFALHDHsTLKIGKRLFLTATP 191
Cdd:smart00487 138 AHRLLDGGFGDQLEKLLKL-LPKNVQLLLLSATP 170
|
|
| |
