|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05326 |
PRK05326 |
potassium/proton antiporter; |
3-569 |
0e+00 |
|
potassium/proton antiporter;
Pssm-ID: 235410 [Multi-domain] Cd Length: 562 Bit Score: 730.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 3 ATTVNSFFFIGALLVGASVLLSALSSRVGIPILVIFLAVGMLAGEDGPGGIHFADYSVAYLVGNLALAIILLDGGMRTRV 82
Cdd:PRK05326 1 MDTINSLLLIGALLLLLSILASRLSSRLGIPSLLLFLAIGMLAGEDGLGGIQFDNYPLAYLVGNLALAVILFDGGLRTRW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 83 SSFRVALWPALSLATVGVAITTGLTGLAAAWLFDLNLMQGMLIGAIVGSTDAAAVFSLLGGRS--LNERVSATLEIESGS 160
Cdd:PRK05326 81 SSFRPALGPALSLATLGVLITAGLTGLFAHWLLGLDWLEGLLLGAIVGSTDAAAVFSLLRGKGlnLKERVASTLEIESGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 161 NDPMAVFLTVTLIEVLATAQQGLDAGFLLLqLVKQFGLGAGIGLAGGWLLWKLINSAKL-APGLYPLLTVSGGLLIFALT 239
Cdd:PRK05326 161 NDPMAVFLTITLIELITGGETGLSWGFLLL-FLQQFGLGALIGLLGGWLLVQLLNRIALpAEGLYPILVLAGALLIFALT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 240 TAVGGSGILAIYLTGLLLGNLSLRSRSTTLSVLDGLTWLSQIGMFLVLGLLASPHKLLPIALPALALAMWMILFARPVSV 319
Cdd:PRK05326 240 AALGGSGFLAVYLAGLVLGNRPIRHRHSILRFFDGLAWLAQIGMFLVLGLLVTPSRLLDIALPALLLALFLILVARPLAV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 320 WIGLLPFKnFAPRERWFISWVGLRGAVPIILAVFPMMAGLPNAQLYFNVAFFVVLVSLILQGSSLPLASKLARVEVPAPP 399
Cdd:PRK05326 320 FLSLLPFR-FNLREKLFISWVGLRGAVPIVLATFPMMAGLPNAQLIFNVVFFVVLVSLLLQGTTLPWAARKLGVVVPPEA 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 400 SPINRSGLEIDLDSQWETFVYRLSAEKWCIGSPLRELRMPQGTRICALFRGQELLHPSGSTCLQSDDILCVIGHEHDLPA 479
Cdd:PRK05326 399 RPVSRVELDPLEESDAELLEYRVPAGSWLVGKALRDLRLPRGALIALIIRDGKLLVPTGSTRLKAGDVLLVLGPERDLPA 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 480 LGQLFSQAPEQDLGPRFFGDFLLEANARLVDLAPLYGLDVSevaDQSLGDFIAHQLGDNLVVGDHVAWQGLLWTVAemeE 559
Cdd:PRK05326 479 LERLFSQSPPGKLDQRFFGDFILEGDAKLADLALIYGLELD---QQTLGELIKQRLGGAPVVGDQVELGGIILTVA---E 552
|
570
....*....|
gi 498359891 560 GEPRKIGVRF 569
Cdd:PRK05326 553 GRVTKVGLRL 562
|
|
| NhaP2 |
COG3263 |
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ... |
5-499 |
0e+00 |
|
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];
Pssm-ID: 442494 [Multi-domain] Cd Length: 502 Bit Score: 642.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 5 TVNSFFFIGALLVGASVLLSALSSRVGIPILVIFLAVGMLAGEDGPGGIHFADYSVAYLVGNLALAIILLDGGMRTRVSS 84
Cdd:COG3263 3 TLNLILLIGALLLLLSILASKLSSRLGVPLLLLFLGIGMLAGEDGLGGIQFDDAELAQLIGSLALAVILFDGGLRTRWSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 85 FRVALWPALSLATVGVAITTGLTGLAAAWLFDLNLMQGMLIGAIVGSTDAAAVFSLLGGR--SLNERVSATLEIESGSND 162
Cdd:COG3263 83 FRPVLAPALSLATLGVLLTAGLTGVFAHWLLGLSWLEGLLLGAIVSSTDAAAVFSILRSKglNLKERLASTLELESGSND 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 163 PMAVFLTVTLIEVLATAQQGLdaGFLLLQLVKQFGLGAGIGLAGGWLLWKLINSAKL-APGLYPLLTVSGGLLIFALTTA 241
Cdd:COG3263 163 PMAVFLTIALIELITGGGASG--WSLLLLFVLQMGLGALVGLAGGWLGVWLLNRIRLpAEGLYPVLVLALALLAFGATAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 242 VGGSGILAIYLTGLLLGNLSLRSRSTTLSVLDGLTWLSQIGMFLVLGLLASPHKLLPIALPALALAMWMILFARPVSVWI 321
Cdd:COG3263 241 LGGSGFLAVYLAGLVLGNRRLPHKKSILRFHDGLAWLAQIGMFLMLGLLVFPSRLLPVALPALLIALFLIFVARPLAVFL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 322 GLLPFKnFAPRERWFISWVGLRGAVPIILAVFPMMAGLPNAQLYFNVAFFVVLVSLILQGSSLPLASKLARVEVPAPPSP 401
Cdd:COG3263 321 SLLPFR-FSWREKLFISWVGLRGAVPIVLATFPLLAGLPGAQLIFNVVFFVVLVSLLVQGTTLPPVARKLGLEVPPEPKP 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 402 INRSGLEIDLDSQWETFVYRLSAEKWCIGSPLRELRMPQGTRICALFRGQELLHPSGSTCLQSDDILCVIGHEHDLPALG 481
Cdd:COG3263 400 LTRVELELLEELDAELVEYRVPPGSPAVGKTLRELRLPEGALVVLIVRDGELLVPRGSTRLQAGDQLLVLAPPEDLEALE 479
|
490
....*....|....*...
gi 498359891 482 QLFSQAPEQDLGPRFFGD 499
Cdd:COG3263 480 RLFAAVSRAGTLAEWFGD 497
|
|
| Na_H_Exchanger |
pfam00999 |
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ... |
15-385 |
5.65e-44 |
|
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
Pssm-ID: 425982 [Multi-domain] Cd Length: 377 Bit Score: 160.50 E-value: 5.65e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 15 LLVGASVLLSALSSRVGIPILVIFLAVGMLAGEDGPGGIHFADYSVaYLVGNLALAIILLDGGMRTRVSSFRVALWPALS 94
Cdd:pfam00999 3 LLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLISEVDEDL-EVLSNLGLPPLLFLAGLELDLRELRKNGGSILL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 95 LATVGVAITTGLTGLAAAWL-FDLNLMQGMLIGAIVGSTDAAAVFSLLGGR-SLNERVSATLEIESGSNDPMAVFLTVTL 172
Cdd:pfam00999 82 LALLGVLIPFVLIGLLLYLLgLGIPLLEALLFGAILSATSPVVVLAILKELgRVPERLGTLLLGESVLNDGVAVVLLAVL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 173 IEVLATAQQGLDAGFLLLQLVKQFGLGAGIGLAGGWLLWKLINSAKLAPGLYPLLTVSGGLLIFALTTAVGGSGILAIYL 252
Cdd:pfam00999 162 LALAQGVGGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLITRFTDDDRELEVLLVLLLALLAALLAEALGVSGILGAFL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 253 TGLLLGNLSLRSRsTTLSVLDGLTWLSQIGMFLVLGLLASPHKLLPIALPALALAMWMILFARPVSVWIgLLPFKNFAPR 332
Cdd:pfam00999 242 AGLVLSEYPFANK-LSEKLEPFGYGLFNPLFFVLVGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFL-LLRLLGLSLR 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 498359891 333 ERWFISWVGL-RGAVPIILAVFPMMAGLPNAQLYFnVAFFVVLVSLILQGSSLP 385
Cdd:pfam00999 320 EALIIGFGGLqRGAVSLALAAIGPLLGIIARELYP-LLIVVVLFTVLVQGITLK 372
|
|
| a_cpa1 |
TIGR00831 |
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC ... |
16-393 |
9.95e-21 |
|
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129911 [Multi-domain] Cd Length: 525 Bit Score: 95.72 E-value: 9.95e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 16 LVGASVLLSALSSRVGIPILVIFLAVGMLAGEDGPGGIHFADYSVAYLvgnLALAIILLDGGMRTRVSSFRVALWPALSL 95
Cdd:TIGR00831 6 LVMLATAVAVTVKFIRLPYPIALILAGLLLGLAGLLPEVPLDREIVLF---LFLPPLLFEAAMNTDLRELRENFRPIALI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 96 ATVGVAITTGLTGLAAAWLFDLNLMQGMLIGAIVGSTDAAAVFSLLGGRSLNERVSATLEIESGSNDPMAVFLTVTLIEV 175
Cdd:TIGR00831 83 AFLLVVVTTVVVGFSLNWILGIPLALALILGAVLSPTDAVAVLGTFKSIRAPKKLSILLEGESLLNDGAALVVFAIAVAV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 176 lATAQQGLDAGFLLLQLVKQFGLGAGIGLAGGWLLWKLINSAKLAPGLYPLLTVSGGLLIFALTTAVGGSGILAIYLTGL 255
Cdd:TIGR00831 163 -ALGKGVFDPLNAALDFAVVCVGGIAAGLAVGYLAYRLLRAKIDDPLVEIALTILAPFAGFLLAERFHFSGVIAVVAAGL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 256 LLGN------LSLRSRSTTLSVLDGLTWLSQIGMFLVLGL-------LASPHKLLPIALPALALAMWMILFArPVSVWIG 322
Cdd:TIGR00831 242 ILTNygrdfsMSPTTRLIALDFWSVIVFLVNGIIFILIGVqtpgtifSAWKEILVAPAAVILALFTNAFVIY-PVMTYVR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 323 LL-------------PFKNFAPRERWFISWVGLRGAVPIILAV-FPMM----AGLPNAQLYFNVAFFVVLVSLILQGSSL 384
Cdd:TIGR00831 321 FLwtmkpfsnrflkkKPMEFGTRWKHVVSWAGLRGAIPLALALsFPNQllsgMAFPARYELVFLAAGVILFSLLVQGISL 400
|
....*....
gi 498359891 385 PLASKLARV 393
Cdd:TIGR00831 401 PIFVKRKFV 409
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05326 |
PRK05326 |
potassium/proton antiporter; |
3-569 |
0e+00 |
|
potassium/proton antiporter;
Pssm-ID: 235410 [Multi-domain] Cd Length: 562 Bit Score: 730.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 3 ATTVNSFFFIGALLVGASVLLSALSSRVGIPILVIFLAVGMLAGEDGPGGIHFADYSVAYLVGNLALAIILLDGGMRTRV 82
Cdd:PRK05326 1 MDTINSLLLIGALLLLLSILASRLSSRLGIPSLLLFLAIGMLAGEDGLGGIQFDNYPLAYLVGNLALAVILFDGGLRTRW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 83 SSFRVALWPALSLATVGVAITTGLTGLAAAWLFDLNLMQGMLIGAIVGSTDAAAVFSLLGGRS--LNERVSATLEIESGS 160
Cdd:PRK05326 81 SSFRPALGPALSLATLGVLITAGLTGLFAHWLLGLDWLEGLLLGAIVGSTDAAAVFSLLRGKGlnLKERVASTLEIESGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 161 NDPMAVFLTVTLIEVLATAQQGLDAGFLLLqLVKQFGLGAGIGLAGGWLLWKLINSAKL-APGLYPLLTVSGGLLIFALT 239
Cdd:PRK05326 161 NDPMAVFLTITLIELITGGETGLSWGFLLL-FLQQFGLGALIGLLGGWLLVQLLNRIALpAEGLYPILVLAGALLIFALT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 240 TAVGGSGILAIYLTGLLLGNLSLRSRSTTLSVLDGLTWLSQIGMFLVLGLLASPHKLLPIALPALALAMWMILFARPVSV 319
Cdd:PRK05326 240 AALGGSGFLAVYLAGLVLGNRPIRHRHSILRFFDGLAWLAQIGMFLVLGLLVTPSRLLDIALPALLLALFLILVARPLAV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 320 WIGLLPFKnFAPRERWFISWVGLRGAVPIILAVFPMMAGLPNAQLYFNVAFFVVLVSLILQGSSLPLASKLARVEVPAPP 399
Cdd:PRK05326 320 FLSLLPFR-FNLREKLFISWVGLRGAVPIVLATFPMMAGLPNAQLIFNVVFFVVLVSLLLQGTTLPWAARKLGVVVPPEA 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 400 SPINRSGLEIDLDSQWETFVYRLSAEKWCIGSPLRELRMPQGTRICALFRGQELLHPSGSTCLQSDDILCVIGHEHDLPA 479
Cdd:PRK05326 399 RPVSRVELDPLEESDAELLEYRVPAGSWLVGKALRDLRLPRGALIALIIRDGKLLVPTGSTRLKAGDVLLVLGPERDLPA 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 480 LGQLFSQAPEQDLGPRFFGDFLLEANARLVDLAPLYGLDVSevaDQSLGDFIAHQLGDNLVVGDHVAWQGLLWTVAemeE 559
Cdd:PRK05326 479 LERLFSQSPPGKLDQRFFGDFILEGDAKLADLALIYGLELD---QQTLGELIKQRLGGAPVVGDQVELGGIILTVA---E 552
|
570
....*....|
gi 498359891 560 GEPRKIGVRF 569
Cdd:PRK05326 553 GRVTKVGLRL 562
|
|
| NhaP2 |
COG3263 |
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ... |
5-499 |
0e+00 |
|
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];
Pssm-ID: 442494 [Multi-domain] Cd Length: 502 Bit Score: 642.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 5 TVNSFFFIGALLVGASVLLSALSSRVGIPILVIFLAVGMLAGEDGPGGIHFADYSVAYLVGNLALAIILLDGGMRTRVSS 84
Cdd:COG3263 3 TLNLILLIGALLLLLSILASKLSSRLGVPLLLLFLGIGMLAGEDGLGGIQFDDAELAQLIGSLALAVILFDGGLRTRWSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 85 FRVALWPALSLATVGVAITTGLTGLAAAWLFDLNLMQGMLIGAIVGSTDAAAVFSLLGGR--SLNERVSATLEIESGSND 162
Cdd:COG3263 83 FRPVLAPALSLATLGVLLTAGLTGVFAHWLLGLSWLEGLLLGAIVSSTDAAAVFSILRSKglNLKERLASTLELESGSND 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 163 PMAVFLTVTLIEVLATAQQGLdaGFLLLQLVKQFGLGAGIGLAGGWLLWKLINSAKL-APGLYPLLTVSGGLLIFALTTA 241
Cdd:COG3263 163 PMAVFLTIALIELITGGGASG--WSLLLLFVLQMGLGALVGLAGGWLGVWLLNRIRLpAEGLYPVLVLALALLAFGATAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 242 VGGSGILAIYLTGLLLGNLSLRSRSTTLSVLDGLTWLSQIGMFLVLGLLASPHKLLPIALPALALAMWMILFARPVSVWI 321
Cdd:COG3263 241 LGGSGFLAVYLAGLVLGNRRLPHKKSILRFHDGLAWLAQIGMFLMLGLLVFPSRLLPVALPALLIALFLIFVARPLAVFL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 322 GLLPFKnFAPRERWFISWVGLRGAVPIILAVFPMMAGLPNAQLYFNVAFFVVLVSLILQGSSLPLASKLARVEVPAPPSP 401
Cdd:COG3263 321 SLLPFR-FSWREKLFISWVGLRGAVPIVLATFPLLAGLPGAQLIFNVVFFVVLVSLLVQGTTLPPVARKLGLEVPPEPKP 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 402 INRSGLEIDLDSQWETFVYRLSAEKWCIGSPLRELRMPQGTRICALFRGQELLHPSGSTCLQSDDILCVIGHEHDLPALG 481
Cdd:COG3263 400 LTRVELELLEELDAELVEYRVPPGSPAVGKTLRELRLPEGALVVLIVRDGELLVPRGSTRLQAGDQLLVLAPPEDLEALE 479
|
490
....*....|....*...
gi 498359891 482 QLFSQAPEQDLGPRFFGD 499
Cdd:COG3263 480 RLFAAVSRAGTLAEWFGD 497
|
|
| NhaP |
COG0025 |
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]; |
8-399 |
4.17e-57 |
|
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 439796 [Multi-domain] Cd Length: 506 Bit Score: 199.42 E-value: 4.17e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 8 SFFFIGALLVGASVLLSALSSRVGIPILVIFLAVGMLAGeDGPGGIHFADYSVAYLVGNLALAIILLDGGMRTRVSSFRV 87
Cdd:COG0025 2 ELLLLILLLLLLGLLSQWLARRLKLPAPLLLLLAGILLG-PGLGLELDPELGDLEPLLELFLPPLLFEAALNLDLRELRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 88 ALWPALSLATVGVAITTGLTGLAAAWLFDLNLMQGMLIGAIVGSTDAAAVFSLLGGRSLNERVSATLEIESGSNDPMAVF 167
Cdd:COG0025 81 NGRPILRLAVVGVLLTTLAVALAAHWLLGLPLAAALLLGAILAPTDPVAVSPILRRLGVPKRLRTILEGESLLNDATALV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 168 LTVTLIEVLATaqQGLDAGFLLLQLVKQFGLGAGIGLAGGWLLWKLINSAKlAPGLYPLLTVSGGLLIFALTTAVGGSGI 247
Cdd:COG0025 161 LFVLALAAALG--GGFSLGEALLDFLLAILGGILVGLLLGWLLGRLLRRLP-DPLLEILLTLALPFLAYLLAEALHGSGV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 248 LAIYLTGLLLGN-----LSLRSRSTTLSVLDGLTWLSQIGMFLVLGLLASPHKLLPIALPALALAMWMILFARPVSVWIG 322
Cdd:COG0025 238 LAVVVAGLVLGNagrrsLSPETRLQLLEFWETLEFLLNSLLFVLLGAQLPLILLGALGLGGILLVLLALLVVRPLWVFLS 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 323 L-LPFKNFAPRERWFISWVGLRGAVPIILAVFP---MMAGLPNAQLYFNVAFFVVLVSLILQGSSLPLASKLARVEVPAP 398
Cdd:COG0025 318 LaLRGSRLSWRERLFLSWGGPRGIVSLALALSLplhGGAGFPGRDLILALAFGVILLTLVLQGLTLPPLARRLGLREDEP 397
|
.
gi 498359891 399 P 399
Cdd:COG0025 398 E 398
|
|
| Na_H_Exchanger |
pfam00999 |
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ... |
15-385 |
5.65e-44 |
|
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
Pssm-ID: 425982 [Multi-domain] Cd Length: 377 Bit Score: 160.50 E-value: 5.65e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 15 LLVGASVLLSALSSRVGIPILVIFLAVGMLAGEDGPGGIHFADYSVaYLVGNLALAIILLDGGMRTRVSSFRVALWPALS 94
Cdd:pfam00999 3 LLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLISEVDEDL-EVLSNLGLPPLLFLAGLELDLRELRKNGGSILL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 95 LATVGVAITTGLTGLAAAWL-FDLNLMQGMLIGAIVGSTDAAAVFSLLGGR-SLNERVSATLEIESGSNDPMAVFLTVTL 172
Cdd:pfam00999 82 LALLGVLIPFVLIGLLLYLLgLGIPLLEALLFGAILSATSPVVVLAILKELgRVPERLGTLLLGESVLNDGVAVVLLAVL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 173 IEVLATAQQGLDAGFLLLQLVKQFGLGAGIGLAGGWLLWKLINSAKLAPGLYPLLTVSGGLLIFALTTAVGGSGILAIYL 252
Cdd:pfam00999 162 LALAQGVGGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLITRFTDDDRELEVLLVLLLALLAALLAEALGVSGILGAFL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 253 TGLLLGNLSLRSRsTTLSVLDGLTWLSQIGMFLVLGLLASPHKLLPIALPALALAMWMILFARPVSVWIgLLPFKNFAPR 332
Cdd:pfam00999 242 AGLVLSEYPFANK-LSEKLEPFGYGLFNPLFFVLVGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFL-LLRLLGLSLR 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 498359891 333 ERWFISWVGL-RGAVPIILAVFPMMAGLPNAQLYFnVAFFVVLVSLILQGSSLP 385
Cdd:pfam00999 320 EALIIGFGGLqRGAVSLALAAIGPLLGIIARELYP-LLIVVVLFTVLVQGITLK 372
|
|
| a_cpa1 |
TIGR00831 |
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC ... |
16-393 |
9.95e-21 |
|
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129911 [Multi-domain] Cd Length: 525 Bit Score: 95.72 E-value: 9.95e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 16 LVGASVLLSALSSRVGIPILVIFLAVGMLAGEDGPGGIHFADYSVAYLvgnLALAIILLDGGMRTRVSSFRVALWPALSL 95
Cdd:TIGR00831 6 LVMLATAVAVTVKFIRLPYPIALILAGLLLGLAGLLPEVPLDREIVLF---LFLPPLLFEAAMNTDLRELRENFRPIALI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 96 ATVGVAITTGLTGLAAAWLFDLNLMQGMLIGAIVGSTDAAAVFSLLGGRSLNERVSATLEIESGSNDPMAVFLTVTLIEV 175
Cdd:TIGR00831 83 AFLLVVVTTVVVGFSLNWILGIPLALALILGAVLSPTDAVAVLGTFKSIRAPKKLSILLEGESLLNDGAALVVFAIAVAV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 176 lATAQQGLDAGFLLLQLVKQFGLGAGIGLAGGWLLWKLINSAKLAPGLYPLLTVSGGLLIFALTTAVGGSGILAIYLTGL 255
Cdd:TIGR00831 163 -ALGKGVFDPLNAALDFAVVCVGGIAAGLAVGYLAYRLLRAKIDDPLVEIALTILAPFAGFLLAERFHFSGVIAVVAAGL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 256 LLGN------LSLRSRSTTLSVLDGLTWLSQIGMFLVLGL-------LASPHKLLPIALPALALAMWMILFArPVSVWIG 322
Cdd:TIGR00831 242 ILTNygrdfsMSPTTRLIALDFWSVIVFLVNGIIFILIGVqtpgtifSAWKEILVAPAAVILALFTNAFVIY-PVMTYVR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 323 LL-------------PFKNFAPRERWFISWVGLRGAVPIILAV-FPMM----AGLPNAQLYFNVAFFVVLVSLILQGSSL 384
Cdd:TIGR00831 321 FLwtmkpfsnrflkkKPMEFGTRWKHVVSWAGLRGAIPLALALsFPNQllsgMAFPARYELVFLAAGVILFSLLVQGISL 400
|
....*....
gi 498359891 385 PLASKLARV 393
Cdd:TIGR00831 401 PIFVKRKFV 409
|
|
| KefB |
COG0475 |
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ... |
8-379 |
7.98e-18 |
|
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];
Pssm-ID: 440243 [Multi-domain] Cd Length: 384 Bit Score: 85.58 E-value: 7.98e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 8 SFFFIGALLVGASVLLSALSSRVGIPILVIFLAVGMLAGEDGPGGIHfaDYSVAYLVGNLALAIILLDGGMRTRVSSFRV 87
Cdd:COG0475 4 SLLLQLGLLLLAAVLAGLLARRLGLPSVLGYILAGILLGPSGLGLIE--DSEALELLAELGVVLLLFLIGLELDLKRLRK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 88 ALWPALSLATVGVAITTGLtGLAAAWLFDLNLMQGMLIGAIVGSTDAAAVFSLLGGRSLNERVSATLEIESGSNDPMAVF 167
Cdd:COG0475 82 MGRRALGIGLLQVLLPFLL-GFLLALLLGLSLAAALFLGAALAATSTAIVLKVLKELGLLKTPLGQLILGVALFDDIAAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 168 LTVTLieVLATAQQGLDAGFLLLQLVKQFGLGAGIGLAGGWLLWKLIN--SAKLAPGLYPLLTVSGGLLIFALTTAVGGS 245
Cdd:COG0475 161 LLLAL--VPALAGGGSVAGSLLLALLKALLFLALLLLVGRYLLRRLFRlvARTRSRELFLLFALLLVLLAAALAELLGLS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 246 GILAIYLTGLLLGNLSLRSRstTLSVLDGLTWLSqIGMFLVL-GLLASPHKLLPIALPALALAMWMILfARPVSVWIGLL 324
Cdd:COG0475 239 AALGAFLAGLVLAESEYRHE--LEEKIEPFGDLF-LPLFFVSvGLSLDLSALLSNPLLALLLVLAAIV-GKLLGAYLAAR 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 498359891 325 PFKnFAPRERWFIsWVGL--RGAVPIILAVFPMMAGLPNAQLyFNVAFFVVLVSLIL 379
Cdd:COG0475 315 LFG-LSRREALRI-GLLLapRGEFALVLASLGLSAGLISPEL-FAALVLVVLLTTLL 368
|
|
| b_cpa1 |
TIGR00840 |
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ... |
24-381 |
4.61e-10 |
|
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273294 [Multi-domain] Cd Length: 559 Bit Score: 62.10 E-value: 4.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 24 SALSSRVGipiLVIFLAVGMLAGEDGPggihFADYSVAYLVgnlALAIILLDGGMRTRVSSFRVALWPALSLATVGV--- 100
Cdd:TIGR00840 38 SVLLIVYG---LLVGGIIKASPHIDPP----TLDSSYFFLY---LLPPIVLDAGYFMPQRNFFENLGSILIFAVVGTlin 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 101 AITTGLTgLAAAWLF------DLNLMQGMLIGAIVGSTDAAAVFSLLGGRSLNERVSATLEIESGSNDPMAVFLTVTLIE 174
Cdd:TIGR00840 108 AFVIGLS-LYGICLIggfgsiDIGLLDNLLFGSLISAVDPVAVLAVFEEYHVNEKLYIIIFGESLLNDAVTVVLYNTFIK 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 175 VLATAQQGLDAGFLLLQLVKQFGLG---AGIGLAGGWLLWKLINSAKLAPGLYPLLTVSGGLLIFALTTAVGGSGILAIY 251
Cdd:TIGR00840 187 FHKTADEPVTIVDVFEGCASFFVVTcggLLVGVVFGFLVAFITRFTHHIRQIEPLFVFLISYLSYLFAETLHLSGILALI 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 252 LTGLLL-----GNLSLRSRSTTLSVLDGLTWLSQIGMFLVLGL-LASPHKLLPIALPALALA---MWMILFARPVSVWIG 322
Cdd:TIGR00840 267 FCGITMkkyveANMSRRSQTTIKYFMKMLSSLSETLIFIFLGVsLVTENHEWNWAFVVATLSfcvIYRVLGVRTLSWITN 346
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 498359891 323 LLPFKNFAPRERWFISWVGLRGAVPIILAVFPMMAGLPNAQLYFNVAFFVVLVSLILQG 381
Cdd:TIGR00840 347 EFRPVEIPYKDQLVIFYAGLRGAVAFALALLLDEKIFPYKFLFVTTTLVVVFFTVIFQG 405
|
|
| TrkA_C |
pfam02080 |
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ... |
420-484 |
7.73e-10 |
|
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.
Pssm-ID: 460440 [Multi-domain] Cd Length: 70 Bit Score: 55.31 E-value: 7.73e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 498359891 420 YRLSAEKWCIGSPLRELRMPQ--GTRICALFRGQELLHPSGSTCLQSDDILCVIGHEHDLPALGQLF 484
Cdd:pfam02080 4 VTVPENSPLVGKTLKELNLPErfGVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
|
|
| CorC_HlyC |
pfam03471 |
Transporter associated domain; This small domain is found in a family of proteins with the ... |
495-571 |
6.63e-09 |
|
Transporter associated domain; This small domain is found in a family of proteins with the pfam01595 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.
Pssm-ID: 460935 [Multi-domain] Cd Length: 81 Bit Score: 52.93 E-value: 6.63e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 498359891 495 RFFGDFLLEANARLVDLAPLYGLDVSEVADQSLGDFIAHQLGDNLVVGDH--VAWQGLLWTVAEMEEGEPRKIGVRFLE 571
Cdd:pfam03471 3 LDDGSYLVDGRAPLDDLNELLGLELPEEDYDTLGGLVLERLGRIPKVGDKveVELGGLRFTVLEMDGRRIKKVRITKLE 81
|
|
| trkA |
PRK09496 |
Trk system potassium transporter TrkA; |
429-484 |
8.10e-07 |
|
Trk system potassium transporter TrkA;
Pssm-ID: 236541 [Multi-domain] Cd Length: 453 Bit Score: 51.66 E-value: 8.10e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 498359891 429 IGSPLRELR--MPQ-GTRICALFRGQELLHPSGSTCLQSDDILCVIGHEHDLPALGQLF 484
Cdd:PRK09496 166 VGKPLSDLRehFPDiDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIGAREHIRAVMSEF 224
|
|
| TlyC |
COG1253 |
Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction ... |
498-574 |
1.34e-05 |
|
Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction only];
Pssm-ID: 440865 [Multi-domain] Cd Length: 435 Bit Score: 47.81 E-value: 1.34e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 498359891 498 GDFLLEANARLVDLAPLYGLDVSEVAD-QSLGDFIAHQLGDNLVVGDHVAWQGLLWTVAEMEEGEPRKIGVRFLEEDP 574
Cdd:COG1253 355 GSYLVDGRLPIDELNELLGLDLPEEEDyETLGGLVLEQLGRIPEVGETVEVDGLRFEVLDMDGRRIDKVLVTRLPEEE 432
|
|
| TrkA |
COG0569 |
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ... |
412-468 |
3.65e-04 |
|
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];
Pssm-ID: 440335 [Multi-domain] Cd Length: 296 Bit Score: 42.75 E-value: 3.65e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 498359891 412 DSQWETFVYRLSAEKWCIGSPLRELRMPQ--GTRICALFRGQELLHPSGSTCLQSDDIL 468
Cdd:COG0569 237 DGDAEIVEVTVPEGSPLVGKTLKELDLREryGVTVVAIKRGGEVIIPSGDTVLEAGDEL 295
|
|
| KhtT |
COG0490 |
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ... |
357-484 |
5.34e-04 |
|
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];
Pssm-ID: 440256 [Multi-domain] Cd Length: 140 Bit Score: 40.68 E-value: 5.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359891 357 AGLPNAQLYFNVAFFVVLVSLILQGSSLPLASKLARVEVPAPPSPINRSGLEIDLDSQWETFVYRLSAEKWCIGSPLREL 436
Cdd:COG0490 10 IILLLLLALAALLVAIVIVGVLGLILRGLLLLELALLLLLLGELLRLLTRLLIELVLLLAIEEVKVPPGSPLVGKTLGEL 89
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 498359891 437 RMPQ--GTRICALFRGQE-LLHPSGSTCLQSDDILCVIGHEHDLPALGQLF 484
Cdd:COG0490 90 NLRQrtGVTVVAIRRGGEvILSPGPDTVLEAGDTLVVVGTREQLERLEELL 140
|
|
| trkA |
PRK09496 |
Trk system potassium transporter TrkA; |
428-489 |
2.00e-03 |
|
Trk system potassium transporter TrkA;
Pssm-ID: 236541 [Multi-domain] Cd Length: 453 Bit Score: 40.88 E-value: 2.00e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 498359891 428 CIGSPLRELRMPQGTRICALFRGQELLHPSGSTCLQSDD--ILCVIgHEHDLPALGQLFSQAPE 489
Cdd:PRK09496 391 VVGKPLKDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDhvIVFVL-DKKFVPDVEKLFQVSPF 453
|
|
| |
