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Conserved domains on  [gi|498113747|ref|WP_010427903|]
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MULTISPECIES: xanthine phosphoribosyltransferase [Enterobacteriaceae]

Protein Classification

xanthine phosphoribosyltransferase( domain architecture ID 10793156)

xanthine phosphoribosyltransferase converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis

EC:  2.4.2.22
Gene Ontology:  GO:0016763|GO:0046110|GO:0043101|GO:0000310
PubMed:  9100006|11933250

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09177 PRK09177
xanthine-guanine phosphoribosyltransferase; Validated
 1-152 8.02e-113

xanthine-guanine phosphoribosyltransferase; Validated


:

Pssm-ID: 236395  Cd Length: 156  Bit Score: 316.03  E-value: 8.02e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498113747   1 MSEKYVVTWDMLQIHARKLAARLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELTVLKRAEGD 80
Cdd:PRK09177   4 MSKKFPVSWDQLHRDARALAWRLLPAGQWKGIIAVTRGGLVPAAILARELGIRLVDTVCISSYDHDNQGELKVLKRAEGD 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498113747  81 GEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRPLVDDYVIDIPQDTWIEQPWDMGVVFVPPISGR 152
Cdd:PRK09177  84 GEGFLVVDDLVDTGGTARAVREMYPKAHFATVYAKPAGRPLVDTYVTDVPQDTWIEFPWDMGLTFVPPLADG 155
 
Name Accession Description Interval E-value
PRK09177 PRK09177
xanthine-guanine phosphoribosyltransferase; Validated
 1-152 8.02e-113

xanthine-guanine phosphoribosyltransferase; Validated


Pssm-ID: 236395  Cd Length: 156  Bit Score: 316.03  E-value: 8.02e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498113747   1 MSEKYVVTWDMLQIHARKLAARLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELTVLKRAEGD 80
Cdd:PRK09177   4 MSKKFPVSWDQLHRDARALAWRLLPAGQWKGIIAVTRGGLVPAAILARELGIRLVDTVCISSYDHDNQGELKVLKRAEGD 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498113747  81 GEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRPLVDDYVIDIPQDTWIEQPWDMGVVFVPPISGR 152
Cdd:PRK09177  84 GEGFLVVDDLVDTGGTARAVREMYPKAHFATVYAKPAGRPLVDTYVTDVPQDTWIEFPWDMGLTFVPPLADG 155
Hpt1 COG2236
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine ...
 1-141 2.92e-35

Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 441837 [Multi-domain]  Cd Length: 153  Bit Score: 119.57  E-value: 2.92e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498113747   1 MSEKYVVTWDMLQIHARKLAARLMPSE-QWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQR-ELTVLKR-- 76
Cdd:COG2236    3 KFKKEYLSWDEIHELSRRLAEQILESGfRPDVIVAIARGGLVPARILADALGVPDLASIRVSSYTGTAKRlEEPVVKGpl 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 498113747  77 -AEGDGEGFIVIDDLVDTGGTAVAIREMY-----PKAHFVTIFAKPAGRPLVDDYVIDIpqDTWIEQPWDM 141
Cdd:COG2236   83 dEDLAGKRVLIVDDVADTGRTLEAVRDLLkeagpAEVRTAVLYYKPSSKFKPDYYAEET--DAWIVFPWEL 151
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 14-145 4.04e-17

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 73.17  E-value: 4.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498113747   14 IHARKLAARLMPSEQWKG--IIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELTVLKRAEGDGEGFIVIDDLV 91
Cdd:pfam00156  13 KAVARLAAQINEDYGGKPdvVVGILRGGLPFAGILARRLDVPLAFVRKVSYNPDTSEVMKTSSALPDLKGKTVLIVDDIL 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 498113747   92 DTGGTAVA----IREMYPK-AHFVTIFAKPAGRPLVDDYVIDIpqDTWIEQPWDMGVVF 145
Cdd:pfam00156  93 DTGGTLLKvlelLKNVGPKeVKIAVLIDKPAGTEPKDKYDKRV--DDWIVFVVGFGLDE 149
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 32-129 2.75e-12

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 60.10  E-value: 2.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498113747  32 IIAVSRGGLVPGALLARELGIRhVDTVCISSYDHDNQRELTVLKRAEGD----GEGFIVIDDLVDTGGTAVAIREMYPKA 107
Cdd:cd06223   19 VVGILRGGLPLAAALARALGLP-LAFIRKERKGPGRTPSEPYGLELPLGgdvkGKRVLLVDDVIATGGTLLAAIELLKEA 97

                         90       100       110
                 ....*....|....*....|....*....|...
gi 498113747 108 -----HFVTIFAKPAGR------PLVDDYVIDI 129
Cdd:cd06223   98 gakvvGVAVLLDKPEGGarelasPGDPVYSLFT 130
 
Name Accession Description Interval E-value
PRK09177 PRK09177
xanthine-guanine phosphoribosyltransferase; Validated
 1-152 8.02e-113

xanthine-guanine phosphoribosyltransferase; Validated


Pssm-ID: 236395  Cd Length: 156  Bit Score: 316.03  E-value: 8.02e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498113747   1 MSEKYVVTWDMLQIHARKLAARLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELTVLKRAEGD 80
Cdd:PRK09177   4 MSKKFPVSWDQLHRDARALAWRLLPAGQWKGIIAVTRGGLVPAAILARELGIRLVDTVCISSYDHDNQGELKVLKRAEGD 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498113747  81 GEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRPLVDDYVIDIPQDTWIEQPWDMGVVFVPPISGR 152
Cdd:PRK09177  84 GEGFLVVDDLVDTGGTARAVREMYPKAHFATVYAKPAGRPLVDTYVTDVPQDTWIEFPWDMGLTFVPPLADG 155
Hpt1 COG2236
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine ...
 1-141 2.92e-35

Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 441837 [Multi-domain]  Cd Length: 153  Bit Score: 119.57  E-value: 2.92e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498113747   1 MSEKYVVTWDMLQIHARKLAARLMPSE-QWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQR-ELTVLKR-- 76
Cdd:COG2236    3 KFKKEYLSWDEIHELSRRLAEQILESGfRPDVIVAIARGGLVPARILADALGVPDLASIRVSSYTGTAKRlEEPVVKGpl 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 498113747  77 -AEGDGEGFIVIDDLVDTGGTAVAIREMY-----PKAHFVTIFAKPAGRPLVDDYVIDIpqDTWIEQPWDM 141
Cdd:COG2236   83 dEDLAGKRVLIVDDVADTGRTLEAVRDLLkeagpAEVRTAVLYYKPSSKFKPDYYAEET--DAWIVFPWEL 151
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 14-145 4.04e-17

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 73.17  E-value: 4.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498113747   14 IHARKLAARLMPSEQWKG--IIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELTVLKRAEGDGEGFIVIDDLV 91
Cdd:pfam00156  13 KAVARLAAQINEDYGGKPdvVVGILRGGLPFAGILARRLDVPLAFVRKVSYNPDTSEVMKTSSALPDLKGKTVLIVDDIL 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 498113747   92 DTGGTAVA----IREMYPK-AHFVTIFAKPAGRPLVDDYVIDIpqDTWIEQPWDMGVVF 145
Cdd:pfam00156  93 DTGGTLLKvlelLKNVGPKeVKIAVLIDKPAGTEPKDKYDKRV--DDWIVFVVGFGLDE 149
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 32-129 2.75e-12

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 60.10  E-value: 2.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498113747  32 IIAVSRGGLVPGALLARELGIRhVDTVCISSYDHDNQRELTVLKRAEGD----GEGFIVIDDLVDTGGTAVAIREMYPKA 107
Cdd:cd06223   19 VVGILRGGLPLAAALARALGLP-LAFIRKERKGPGRTPSEPYGLELPLGgdvkGKRVLLVDDVIATGGTLLAAIELLKEA 97

                         90       100       110
                 ....*....|....*....|....*....|...
gi 498113747 108 -----HFVTIFAKPAGR------PLVDDYVIDI 129
Cdd:cd06223   98 gakvvGVAVLLDKPEGGarelasPGDPVYSLFT 130
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 13-130 1.23e-10

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 56.57  E-value: 1.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498113747  13 QIHAR--KLAARLmpSEQWKG----IIAVSRGGLVPGALLARELGIRH-VDTVCISSYDHDNQ--RELTVLKRAEGDGEG 83
Cdd:COG0634   14 EIQARvkELAAQI--TADYAGkeplVVGVLKGAFVFMADLLRALDFPLeIDFMHVSSYGGGTEssGEVRILKDLDEDIEG 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 498113747  84 --FIVIDDLVDTGGTAVAIREMY----PKA-HFVTIFAKPAGR--PLVDDYV-IDIP 130
Cdd:COG0634   92 rdVLIVEDIIDTGLTLSYLLELLksrgPASvKIATLLDKPERRkvDVPADYVgFEIP 148
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 39-103 2.40e-04

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 39.29  E-value: 2.40e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 498113747  39 GLVPGALLARELGIRHV----------DTVCISsYD--HDNQRELTVLKRAEGDGEGFIVIDDLVDTGGTAVAIREM 103
Cdd:COG0503   59 GFILAAALAYALGVPFVparkpgklpgETVSEE-YDleYGTGDTLELHKDALKPGDRVLIVDDLLATGGTAKAAIKL 134
PRK15423 PRK15423
hypoxanthine phosphoribosyltransferase; Provisional
 16-119 1.26e-03

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 185321  Cd Length: 178  Bit Score: 37.30  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498113747  16 ARKLAARLMPSEQWKGIIAVSRGGLVPGALLARELGIRH-VDTVCISSYDH--DNQRELTVLKRAEGD--GEGFIVIDDL 90
Cdd:PRK15423  22 GRQITERYKDSGSDMVLVGLLRGSFMFMADLCREVQVSHeVDFMTASSYGSgmSTTRDVKILKDLDEDirGKDVLIVEDI 101

                         90       100       110
                 ....*....|....*....|....*....|....
gi 498113747  91 VDTGGTAVAIREMY----PKAHFV-TIFAKPAGR 119
Cdd:PRK15423 102 IDSGNTLSKVREILslrePKSLAIcTLLDKPSRR 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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