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Conserved domains on  [gi|498108705|ref|WP_010422861|]
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MULTISPECIES: DeoR/GlpR family DNA-binding transcription regulator [Pseudomonas]

Protein Classification

DeoR/GlpR family DNA-binding transcription regulator( domain architecture ID 11442564)

DeoR/GlpR family DNA-binding transcription regulator is a helix-turn-helix type transcriptional regulator that may be involved in sugar metabolism

Gene Ontology:  GO:0003700|GO:0003677
PubMed:  15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 5-252 3.38e-90

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


:

Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 267.00  E-value: 3.38e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705   5 NTPQRRHNILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLLLRRYGGAVPLPHEL----ISDGSQPVSRYKQA 80
Cdd:COG1349    2 LAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAaeppFAERETLNAEEKRA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705  81 IARAAVCRIREHARIIVDSGSTTAALIPELGQQPGLVVMTNSLHVARALTELEHEPVlLMTGGTWDPHSESFQGQVAEQV 160
Cdd:COG1349   82 IARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEV-ILLGGELRPSSGSLVGPLAEEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705 161 LRSYDFDQLFIGADGIDLVRGTTTFNELLG-LSRVMAEVAREVVVMVEADKVGRKIPNLELPWSSIHTLITDDRLSSEAR 239
Cdd:COG1349  161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAeVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                        250
                 ....*....|...
gi 498108705 240 DQIQARGINLICA 252
Cdd:COG1349  241 EALEEAGVEVIVA 253
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 5-252 3.38e-90

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 267.00  E-value: 3.38e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705   5 NTPQRRHNILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLLLRRYGGAVPLPHEL----ISDGSQPVSRYKQA 80
Cdd:COG1349    2 LAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAaeppFAERETLNAEEKRA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705  81 IARAAVCRIREHARIIVDSGSTTAALIPELGQQPGLVVMTNSLHVARALTELEHEPVlLMTGGTWDPHSESFQGQVAEQV 160
Cdd:COG1349   82 IARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEV-ILLGGELRPSSGSLVGPLAEEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705 161 LRSYDFDQLFIGADGIDLVRGTTTFNELLG-LSRVMAEVAREVVVMVEADKVGRKIPNLELPWSSIHTLITDDRLSSEAR 239
Cdd:COG1349  161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAeVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                        250
                 ....*....|...
gi 498108705 240 DQIQARGINLICA 252
Cdd:COG1349  241 EALEEAGVEVIVA 253
srlR PRK10434
DNA-binding transcriptional repressor;
8-250 1.39e-86

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 258.08  E-value: 1.39e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705   8 QRRHNILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLLLRRYGGAVpLPHElisDGSQPVSR-------YKQA 80
Cdd:PRK10434   5 QRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVV-LNKE---ESDPPIDHktlinthKKEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705  81 IARAAVCRIREHARIIVDSGSTTAALIPELGQQPGLVVMTNSLHVARALTELEHEPVLLMTGGTWDPHSESFQGQVAEQV 160
Cdd:PRK10434  81 IAEAAVSLIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705 161 LRSYDFDQLFIGADGIDLVRGTTTFNELLGLSRVMAEVAREVVVMVEADKVGRKIPNLELPWSSIHTLITDDRLSSEARD 240
Cdd:PRK10434 161 FEHFTFDKLFIGTDGIDLNAGVTTFNEVYTVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDPAFRQ 240

                        250
                 ....*....|
gi 498108705 241 QIQARGINLI 250
Cdd:PRK10434 241 ALEEKGIEVI 250
AgaR NF040755
transcriptional repressor AgaR;
5-250 1.02e-66

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 207.12  E-value: 1.02e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705   5 NTPQRRHNILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLLLRRYGGA------VPLPHELISDGSQPVSRYK 78
Cdd:NF040755   3 GTSERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGAlindgfIPGAEPSVEDKSRLNTAVK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705  79 QAIARAAVCRIREHARIIVDSGSTTAALIPELGQQPGLVVMTNSLHVARALTELEHEPVlLMTGGTWDPHSESFQGQVAE 158
Cdd:NF040755  83 RLIAAAAAELIKPGDRVILDSGTTTYEIARHLKQHQDVVVMTNGLNVANELLEAEGVEV-LMTGGHLRRQSLSFYGDQAE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705 159 QVLRSYDFDQLFIGADGIDLVRGTTTFNE-LLGLSRVMAEVAREVVVMVEADKVGRKIPNLELPWSSIHTLITDDRLSSE 237
Cdd:NF040755 162 QSLQNYHFDKLFLGVDGFDLERGITTHNEdEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIPEE 241

                        250
                 ....*....|...
gi 498108705 238 ARDQIQARGINLI 250
Cdd:NF040755 242 YLQGLRKLGVEVI 254
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 78-231 1.44e-55

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 175.39  E-value: 1.44e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705   78 KQAIARAAVCRIREHARIIVDSGSTTAALIPELGQQPGLVVMTNSLHVARALTELEHEPVlLMTGGTWDPHSESFQGQVA 157
Cdd:pfam00455   6 KRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEV-ILLGGEVRPKTGAFVGPLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498108705  158 EQVLRSYDFDQLFIGADGIDLVRGTTTFNELLG-LSRVMAEVAREVVVMVEADKVGRKIPNLELPWSSIHTLITD 231
Cdd:pfam00455  85 EEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAeVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITD 159
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
9-60 4.68e-12

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 59.54  E-value: 4.68e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 498108705     9 RRHNILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLLLRRYGGAV 60
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAV 52
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 12-52 1.09e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 39.26  E-value: 1.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 498108705   12 NILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLL 52
Cdd:TIGR01884 147 KILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLV 187
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 12-52 1.28e-03

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 38.90  E-value: 1.28e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 498108705  12 NILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLL 52
Cdd:cd09655  143 KILEVLKAKGEKSVKNIAKKLGKSLSTISRHLRELEKKGLV 183
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 5-252 3.38e-90

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 267.00  E-value: 3.38e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705   5 NTPQRRHNILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLLLRRYGGAVPLPHEL----ISDGSQPVSRYKQA 80
Cdd:COG1349    2 LAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAaeppFAERETLNAEEKRA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705  81 IARAAVCRIREHARIIVDSGSTTAALIPELGQQPGLVVMTNSLHVARALTELEHEPVlLMTGGTWDPHSESFQGQVAEQV 160
Cdd:COG1349   82 IARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEV-ILLGGELRPSSGSLVGPLAEEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705 161 LRSYDFDQLFIGADGIDLVRGTTTFNELLG-LSRVMAEVAREVVVMVEADKVGRKIPNLELPWSSIHTLITDDRLSSEAR 239
Cdd:COG1349  161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAeVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                        250
                 ....*....|...
gi 498108705 240 DQIQARGINLICA 252
Cdd:COG1349  241 EALEEAGVEVIVA 253
srlR PRK10434
DNA-binding transcriptional repressor;
8-250 1.39e-86

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 258.08  E-value: 1.39e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705   8 QRRHNILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLLLRRYGGAVpLPHElisDGSQPVSR-------YKQA 80
Cdd:PRK10434   5 QRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVV-LNKE---ESDPPIDHktlinthKKEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705  81 IARAAVCRIREHARIIVDSGSTTAALIPELGQQPGLVVMTNSLHVARALTELEHEPVLLMTGGTWDPHSESFQGQVAEQV 160
Cdd:PRK10434  81 IAEAAVSLIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705 161 LRSYDFDQLFIGADGIDLVRGTTTFNELLGLSRVMAEVAREVVVMVEADKVGRKIPNLELPWSSIHTLITDDRLSSEARD 240
Cdd:PRK10434 161 FEHFTFDKLFIGTDGIDLNAGVTTFNEVYTVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDPAFRQ 240

                        250
                 ....*....|
gi 498108705 241 QIQARGINLI 250
Cdd:PRK10434 241 ALEEKGIEVI 250
AgaR NF040755
transcriptional repressor AgaR;
5-250 1.02e-66

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 207.12  E-value: 1.02e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705   5 NTPQRRHNILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLLLRRYGGA------VPLPHELISDGSQPVSRYK 78
Cdd:NF040755   3 GTSERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGAlindgfIPGAEPSVEDKSRLNTAVK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705  79 QAIARAAVCRIREHARIIVDSGSTTAALIPELGQQPGLVVMTNSLHVARALTELEHEPVlLMTGGTWDPHSESFQGQVAE 158
Cdd:NF040755  83 RLIAAAAAELIKPGDRVILDSGTTTYEIARHLKQHQDVVVMTNGLNVANELLEAEGVEV-LMTGGHLRRQSLSFYGDQAE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705 159 QVLRSYDFDQLFIGADGIDLVRGTTTFNE-LLGLSRVMAEVAREVVVMVEADKVGRKIPNLELPWSSIHTLITDDRLSSE 237
Cdd:NF040755 162 QSLQNYHFDKLFLGVDGFDLERGITTHNEdEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIPEE 241

                        250
                 ....*....|...
gi 498108705 238 ARDQIQARGINLI 250
Cdd:NF040755 242 YLQGLRKLGVEVI 254
PRK09802 PRK09802
DeoR family transcriptional regulator;
4-253 6.88e-57

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 182.75  E-value: 6.88e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705   4 RNTPQRRHNILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLLLRRYGGA------VPLPHELISDGSQPVSRY 77
Cdd:PRK09802  13 TGTSERREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGAlicdstTPSVEPSVEDKSALNTAM 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705  78 KQAIARAAVCRIREHARIIVDSGSTTAALIPELGQQPGLVVMTNSLHVARALteLEHEPV-LLMTGGTWDPHSESFQGQV 156
Cdd:PRK09802  93 KRSVAKAAVELIQPGHRVILDSGTTTFEIARLMRKHTDVIAMTNGMNVANAL--LEAEGVeLLMTGGHLRRQSQSFYGDQ 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705 157 AEQVLRSYDFDQLFIGADGIDLVRGTTTFNELLG-LSRVMAEVAREVVVMVEADKVGR----KIPNLElpwsSIHTLITD 231
Cdd:PRK09802 171 AEQSLQNYHFDMLFLGVDAIDLERGVSTHNEDEArLNRRMCEVAERIIVVTDSSKFNRsslhKIIDTQ----RIDMIIVD 246

                        250       260
                 ....*....|....*....|..
gi 498108705 232 DRLSSEARDQIQARGINLICAA 253
Cdd:PRK09802 247 EGIPADSLEGLRKAGVEVILVG 268
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 78-231 1.44e-55

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 175.39  E-value: 1.44e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705   78 KQAIARAAVCRIREHARIIVDSGSTTAALIPELGQQPGLVVMTNSLHVARALTELEHEPVlLMTGGTWDPHSESFQGQVA 157
Cdd:pfam00455   6 KRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEV-ILLGGEVRPKTGAFVGPLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498108705  158 EQVLRSYDFDQLFIGADGIDLVRGTTTFNELLG-LSRVMAEVAREVVVMVEADKVGRKIPNLELPWSSIHTLITD 231
Cdd:pfam00455  85 EEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAeVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITD 159
PRK13509 PRK13509
HTH-type transcriptional regulator UlaR;
6-252 8.68e-20

HTH-type transcriptional regulator UlaR;


Pssm-ID: 184100 [Multi-domain]  Cd Length: 251  Bit Score: 85.44  E-value: 8.68e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705   6 TPQRRHN-ILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLLLRRYGGAVPLPHELISDGSQPVSRY-----KQ 79
Cdd:PRK13509   2 TEAQRHQiLLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLKKVRNGAEAITQQRPRWTPMNIHQAqnhdeKV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705  80 AIARAAVCRIREHARIIVDSGSTTAALIPELGQQPgLVVMTNSLHVARALTELEHEPVLLMtGGTWDPhSESFQGQVAEQ 159
Cdd:PRK13509  82 RIAKAASQLCNPGESVVINCGSTAFLLGRELCGKP-VQIITNYLPLANYLIDQEHDSVIIM-GGQYNK-SQSITLSPQGS 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705 160 VLRSYDFDQLFIGADGIDlVRGTTTFNELLGLS-RVMAEVAREVVVMVEADKVGRKIPNLELPWSSIHTLITDDRLSSEA 238
Cdd:PRK13509 159 ENSLYAGHWMFTSGKGLT-ADGLYKTDMLTAMAeQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITGKNADPEV 237

                        250
                 ....*....|....
gi 498108705 239 RDQIQARGINLICA 252
Cdd:PRK13509 238 LQQLEAQGVSILLV 251
PRK10681 PRK10681
DNA-binding transcriptional repressor DeoR; Provisional
 35-251 2.11e-17

DNA-binding transcriptional repressor DeoR; Provisional


Pssm-ID: 182644 [Multi-domain]  Cd Length: 252  Bit Score: 78.97  E-value: 2.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705  35 SEVTIRKDLAALETNGLLLrryGGAVPL-----PHELISDGSQPVSRYKQAIARAAVCRIREHARIIVDSGSTTAALIPE 109
Cdd:PRK10681  34 SEMTIRRDLNAHSAPVVLL---GGYIVLeprsaSHYLLSDQKSRLVEEKRRAAQLAATLVEPNQTLFFDCGTTTPWIIEA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705 110 LGQQPGLVVMTNSLHVARALTELEHEPVLLmTGGTWDPHSESFQGQVAEQVLRSYDFDQLFIGADGIDLVRGTTTFN--E 187
Cdd:PRK10681 111 IDNELPFTAVCYSLNTFLALQEKPHCRAIL-CGGEFHASNAIFKPLDFQQTLDNICPDIAFYSAAGVHVSKGATCFNleE 189

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 498108705 188 LLGLSRVMAeVAREVVVMVEADKVGRKIPNLELPWSSIHTLITDDRLSSEARDQIQARGINLIC 251
Cdd:PRK10681 190 LPVKHWAMA-MAQKHVLVVDHSKFGKVRPARMGDLTRFDTVVSDRCPDDEFVKYAQAQRIKLMY 252
PRK10906 PRK10906
DeoR/GlpR family transcriptional regulator;
8-213 5.85e-14

DeoR/GlpR family transcriptional regulator;


Pssm-ID: 182827 [Multi-domain]  Cd Length: 252  Bit Score: 69.50  E-value: 5.85e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705   8 QRRHNILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLLLRRYGGAVpLPHELIS----DGSQPVSRYKQAIAR 83
Cdd:PRK10906   5 QRHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAA-LPSSSVNtpwhDRKATQTEEKERIAR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705  84 AAVCRIREHARIIVDSGSTTAALIPELGQQPGLVVMTNSLHVARALTELEhEPVLLMTGGTWDPHSESFQGQVAEQVLRS 163
Cdd:PRK10906  84 KVASQIPNGATLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMAKE-DFRIILAGGELRSRDGGIIGEATLDFISQ 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 498108705 164 YDFDQLFIGADGIDLVRGTTTFN-ELLGLSRVMAEVAREVVVMVEADKVGR 213
Cdd:PRK10906 163 FRLDFGILGISGIDSDGSLLEFDyHEVRTKRAIIENSRHVMLVVDHSKFGR 213
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
9-60 4.68e-12

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 59.54  E-value: 4.68e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 498108705     9 RRHNILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLLLRRYGGAV 60
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAV 52
PRK10411 PRK10411
L-fucose operon activator;
9-177 1.07e-11

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 62.90  E-value: 1.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705   9 RRHNILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLLLRRYGGAVPLpHELISDGSQPV-----SRY--KQAI 81
Cdd:PRK10411   5 RQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAKYI-HRQNQDSGDPFhirlkSHYahKADI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498108705  82 ARAAVCRIREHARIIVDSGSTTAALIPELGQQPgLVVMTNSLHVARALTELEHePVLLMTGGTWDPHSESFQGQVAEQVL 161
Cdd:PRK10411  84 AREALAWIEEGMVIALDASSTCWYLARQLPDIN-IQVFTNSHPICQELGKRER-IQLISSGGTLERKYGCYVNPSLISQL 161

                        170
                 ....*....|....*.
gi 498108705 162 RSYDFDQLFIGADGID 177
Cdd:PRK10411 162 KSLEIDLFIFSCEGID 177
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
9-60 2.94e-11

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 57.27  E-value: 2.94e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 498108705    9 RRHNILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLLLRRYGGAV 60
Cdd:pfam08220   1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAV 52
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
9-56 5.71e-06

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 46.07  E-value: 5.71e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 498108705   9 RRHNILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLLLRRY 56
Cdd:COG2345   14 TRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERET 61
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 13-51 3.58e-05

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 40.49  E-value: 3.58e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 498108705   13 ILALLNE-QGEVSVDDLARRFETSEVTIRKDLAALETNGL 51
Cdd:pfam08279   3 ILQLLLEaRGPISGQELAEKLGVSRRTIRRDIKILEELGV 42
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 9-47 1.03e-04

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 42.76  E-value: 1.03e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 498108705   9 RRHNILALLNEQGEVSVDDLARRFETSEVTIRKDLAALE 47
Cdd:COG2378    6 RLLALLQLLQSRRGVTAAELAERLEVSERTIYRDIDALR 44
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 12-52 1.09e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 39.26  E-value: 1.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 498108705   12 NILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLL 52
Cdd:TIGR01884 147 KILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLV 187
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 12-52 1.28e-03

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 38.90  E-value: 1.28e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 498108705  12 NILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLL 52
Cdd:cd09655  143 KILEVLKAKGEKSVKNIAKKLGKSLSTISRHLRELEKKGLV 183
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 7-58 1.51e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.51  E-value: 1.51e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 498108705   7 PQRRhNILALLNEqGEVSVDDLARRFETSEVTIRKDLAALETNGLLLRRYGG 58
Cdd:cd00090    7 PTRL-RILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREG 56
BglG COG3711
Transcriptional antiterminator [Transcription];
5-57 2.41e-03

Transcriptional antiterminator [Transcription];


Pssm-ID: 442925 [Multi-domain]  Cd Length: 618  Bit Score: 39.07  E-value: 2.41e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 498108705   5 NTPQRRHNILA--LLNEQGEVSVDDLARRFETSEVTIRKDLAALETnglLLRRYG 57
Cdd:COG3711   77 LSPKERVAYILlrLLLAGDPISLDDLAEELFVSRSTILNDLKKIEK---ILKKYG 128
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 10-58 7.23e-03

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 35.56  E-value: 7.23e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 498108705  10 RHNILALLNEQGEVSVDDLARRFETSEVTIRKDLAALETNGLLLRRYGG 58
Cdd:PRK10141  18 RLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQG 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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