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Conserved domains on  [gi|498066271|ref|WP_010380427|]
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OsmC domain/YcaO domain-containing protein [Pseudoalteromonas rubra]

Protein Classification

OsmC domain/YcaO domain-containing protein( domain architecture ID 11497147)

OsmC domain/YcaO domain-containing protein may be involved in ATP-dependent peptide cyclodehydration

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TIGR03549 TIGR03549
YcaO domain protein; This family consists of remarkably well-conserved proteins from gamma and ...
2-718 0e+00

YcaO domain protein; This family consists of remarkably well-conserved proteins from gamma and beta Proteobacteria, heavily skewed towards organisms of marine environments. Its gene neighborhood is not conserved. This family has an OsmC-like N-terminal domain. It shares a YcaO domain, frequently associated with ATP-dependent cyclodehydration for peptide modification. The function is unknown. Fifteen of the first sixteen members of this family are from selenouridine-positive genomes, but this correlation may not be meaningful.


:

Pssm-ID: 132588 [Multi-domain]  Cd Length: 718  Bit Score: 1439.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271    2 EIKVNYLDNLRIDAKFDDFSVIADQPIRYKGDGSAPSPFDYFLASSALCAAYFVKVYCNARDIPTDGIRVAQNNIVDPEN 81
Cdd:TIGR03549   1 EIKVNFLDNLRLEAKFDDFTVIADQPIRYKGDGSAPGPFDYFLASSALCAAYFVKVYCNARDIPTENIRLSQNNIVDPED 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271   82 RYNQIFKIQVELPESISEKDRQGILRSIDRCTVKKVIQTGPEFQVEAVESLDDDAQAMLMVNTDSDASTFILGKDLPLEQ 161
Cdd:TIGR03549  81 RYNQIFKIQVELPEDISEKDRQGILRSIDRCTVKKVVQTGPEFQIETVENLDADAQALLMGTPDSGASTYIEGKDLPLEQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  162 TIANMTGILSDLGMKIEVASWRNIVPNVWSLHIRDAASPMCFTNGKGATKESALCSALGEFIERLNCNFFYNDQFFGEEI 241
Cdd:TIGR03549 161 TIANMTAILADLGMKIEIASWRNIVPNVWSLHIRDAASPMCFTNGKGATKESALCSALGEFIERLNCNFFYNDQFFGEDI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  242 ANAEFVHYPNEQWFKPGDNDELPAEILDGYTREIYDPEGELRGSNLIDTNSGNIERGICSIPYTRHSDGETVYFPSNLIE 321
Cdd:TIGR03549 241 ANSAFVHYPNEKWFKPGDDDALPAGILDEYCLAIYNPDGELRGSHLIDTNSGRTDRGICSLPFVRQSDGETVYFPSNLIE 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  322 NLFLSNGMSAGNNLFEAKVQCLSEIFERAVKKQIIEQEIVLPDVPEDVLAKFPGIVAGIKGLEEQGFPVVVKDASLGGQF 401
Cdd:TIGR03549 321 NLFLSNGMSAGNTLAEAQVQCLSEIFERAVKKEIIEEEIVLPDVPQEVLAKYPGILAGIKALEEQGFPVLVKDASLGGQF 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  402 PVMCVTLMNPKTGGVFASFGAHPSLEVALERSLTELLQGRSFEGLNDVPKPTFNSMAVSEPENFVEHFIDSTGVISWRFF 481
Cdd:TIGR03549 401 PVMCVTLMNPRTGGVFASFGAHPSFEVALERSLTELLQGRSFEGLNDLPQPTFNSMAVTEPNNFVEHFIDSSGVVSWRFF 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  482 SAKHDYEFVEWDFTGTNEEECDKLFAILKDLGKEAYIAEFTDMG-TACRILVPGYSEVYPAEDLIWDNTNKALQYREDIL 560
Cdd:TIGR03549 481 SAKHDYDFVEWDFSGTNEEEAATLFGILEDMGKEVYIAVYEDLGaPACRILVPGYSEVYPVEDLIWDNTNKALDYREDIL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  561 NIHSLEDEALADLVNRLEESQLDNYIDIITLIGVEFDENTVWGQLTILELKILIYLALGDIEAAIELVETFLQYNDNTVE 640
Cdd:TIGR03549 561 NLHRLDDEALEDLLERLEESQLDNYTDIRTLIGIEFDENTVWGQLTILELKLLIYLALQRHEDALELVGMFLQFNDNTVE 640
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 498066271  641 RGLFYQAMHATLEVALDEELEIEDYIHSFTRMFGKEVMDAVIGSINGDVKFYGLTPTNMQLEGLDKHLRLIDSYKKLH 718
Cdd:TIGR03549 641 RGLFYQAVNAVLEVTLDEELELEDYRRNFNRMYGEETMDAVIGSVNGSVRFYGLTPTSMKLEGLDRHLRLIESYKKLH 718
 
Name Accession Description Interval E-value
TIGR03549 TIGR03549
YcaO domain protein; This family consists of remarkably well-conserved proteins from gamma and ...
2-718 0e+00

YcaO domain protein; This family consists of remarkably well-conserved proteins from gamma and beta Proteobacteria, heavily skewed towards organisms of marine environments. Its gene neighborhood is not conserved. This family has an OsmC-like N-terminal domain. It shares a YcaO domain, frequently associated with ATP-dependent cyclodehydration for peptide modification. The function is unknown. Fifteen of the first sixteen members of this family are from selenouridine-positive genomes, but this correlation may not be meaningful.


Pssm-ID: 132588 [Multi-domain]  Cd Length: 718  Bit Score: 1439.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271    2 EIKVNYLDNLRIDAKFDDFSVIADQPIRYKGDGSAPSPFDYFLASSALCAAYFVKVYCNARDIPTDGIRVAQNNIVDPEN 81
Cdd:TIGR03549   1 EIKVNFLDNLRLEAKFDDFTVIADQPIRYKGDGSAPGPFDYFLASSALCAAYFVKVYCNARDIPTENIRLSQNNIVDPED 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271   82 RYNQIFKIQVELPESISEKDRQGILRSIDRCTVKKVIQTGPEFQVEAVESLDDDAQAMLMVNTDSDASTFILGKDLPLEQ 161
Cdd:TIGR03549  81 RYNQIFKIQVELPEDISEKDRQGILRSIDRCTVKKVVQTGPEFQIETVENLDADAQALLMGTPDSGASTYIEGKDLPLEQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  162 TIANMTGILSDLGMKIEVASWRNIVPNVWSLHIRDAASPMCFTNGKGATKESALCSALGEFIERLNCNFFYNDQFFGEEI 241
Cdd:TIGR03549 161 TIANMTAILADLGMKIEIASWRNIVPNVWSLHIRDAASPMCFTNGKGATKESALCSALGEFIERLNCNFFYNDQFFGEDI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  242 ANAEFVHYPNEQWFKPGDNDELPAEILDGYTREIYDPEGELRGSNLIDTNSGNIERGICSIPYTRHSDGETVYFPSNLIE 321
Cdd:TIGR03549 241 ANSAFVHYPNEKWFKPGDDDALPAGILDEYCLAIYNPDGELRGSHLIDTNSGRTDRGICSLPFVRQSDGETVYFPSNLIE 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  322 NLFLSNGMSAGNNLFEAKVQCLSEIFERAVKKQIIEQEIVLPDVPEDVLAKFPGIVAGIKGLEEQGFPVVVKDASLGGQF 401
Cdd:TIGR03549 321 NLFLSNGMSAGNTLAEAQVQCLSEIFERAVKKEIIEEEIVLPDVPQEVLAKYPGILAGIKALEEQGFPVLVKDASLGGQF 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  402 PVMCVTLMNPKTGGVFASFGAHPSLEVALERSLTELLQGRSFEGLNDVPKPTFNSMAVSEPENFVEHFIDSTGVISWRFF 481
Cdd:TIGR03549 401 PVMCVTLMNPRTGGVFASFGAHPSFEVALERSLTELLQGRSFEGLNDLPQPTFNSMAVTEPNNFVEHFIDSSGVVSWRFF 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  482 SAKHDYEFVEWDFTGTNEEECDKLFAILKDLGKEAYIAEFTDMG-TACRILVPGYSEVYPAEDLIWDNTNKALQYREDIL 560
Cdd:TIGR03549 481 SAKHDYDFVEWDFSGTNEEEAATLFGILEDMGKEVYIAVYEDLGaPACRILVPGYSEVYPVEDLIWDNTNKALDYREDIL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  561 NIHSLEDEALADLVNRLEESQLDNYIDIITLIGVEFDENTVWGQLTILELKILIYLALGDIEAAIELVETFLQYNDNTVE 640
Cdd:TIGR03549 561 NLHRLDDEALEDLLERLEESQLDNYTDIRTLIGIEFDENTVWGQLTILELKLLIYLALQRHEDALELVGMFLQFNDNTVE 640
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 498066271  641 RGLFYQAMHATLEVALDEELEIEDYIHSFTRMFGKEVMDAVIGSINGDVKFYGLTPTNMQLEGLDKHLRLIDSYKKLH 718
Cdd:TIGR03549 641 RGLFYQAVNAVLEVTLDEELELEDYRRNFNRMYGEETMDAVIGSVNGSVRFYGLTPTSMKLEGLDRHLRLIESYKKLH 718
YcaO_for_S12 NF040716
30S ribosomal protein S12 methylthiotransferase accessory factor YcaO; YcaO acts as a partner ...
150-719 0e+00

30S ribosomal protein S12 methylthiotransferase accessory factor YcaO; YcaO acts as a partner for RimO to achieve the modification of ribosomal protein S12. Homologs of YcaO are involved a wide variety of RiPP (ribosomally translated, post-translationally modified peptide) natural product biosynthesis pathways. Some members of this family have an additional N-terminal OsmC-like domain.


Pssm-ID: 468680 [Multi-domain]  Cd Length: 571  Bit Score: 1074.52  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 150 TFILGKDLPLEQTIANMTGILSDLGMKIEVASWRNIVPNVWSLHIRDAASPMCFTNGKGATKESALCSALGEFIERLNCN 229
Cdd:NF040716   1 TFIPGKDAALEDSIANMQTKLQALGFNIEEASWLNPVPNVWSVHIRDRDCPMLFTNGKGASRKAALASALGEYFERLSTN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 230 FFYNDQFFGEEIANAEFVHYPNEQWFKPGDNDELPAEILDGYTREIYDPEGELRGSNLIDTNSGNIERGICSIPYTRHSD 309
Cdd:NF040716  81 YFFADYYLGEEIANADFVHYPNEKWFPLGDDDSLPEGLLDPELRAFYDPEGELTASDLIDLNSGNAERGICALPYVRQRD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 310 GETVYFPSNLIENLFLSNGMSAGNNLFEAKVQCLSEIFERAVKKQIIEQEIVLPDVPEDVLAKFPGIVAGIKGLEEQGFP 389
Cdd:NF040716 161 GETVYFPVNLIGNLYVSNGMSAGNTLAEARVQGLSEIFERAVKNRIIAEGICLPEVPEEVIARYPAIAAGIEALEAQGFP 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 390 VVVKDASLGGQFPVMCVTLMNPKTGGVFASFGAHPSLEVALERSLTELLQGRSFEGLNDVPKPTFNSMAVSEPENFVEHF 469
Cdd:NF040716 241 VLVKDASLGGQFPVMCVTLLNPKDGGCFASFGAHPRFEVALERTLTELLQGRSLDDLDGFPPPTFDLEEVAEPENLETHF 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 470 IDSTGVISWRFFSAKHDYEFVEWDFTGTNEEECDKLFAILKDLGKEAYIAEFTDMGT-ACRILVPGYSEVYPAEDLIWDN 548
Cdd:NF040716 321 IDSSGVISWDFFSDTPDYEFVDWDFSGTTEEEFDWLIAILHAEGKDVYIADYEHLGVyACRILVPGMSEIYPVEDLIWDN 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 549 TNKALQYREDILNIHSLEDEALADLVNRLEESQLDNYIDIITLIGVEFDENTVWGQLTILELKILIYLALGDIEAAIELV 628
Cdd:NF040716 401 NNVGLLLREALLNLPELDDEQYAELLDRLEESGLDDHQPVAELIGLAPDPGTVWGTLRIGELKLLLALALGDLEAALEWV 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 629 ETFLQYNDNTVERGLFYQAMHATLEVALDEELEIEDYIHSFTRMFGKEVMDAVIGSINGDVKFYGLTPTNMQLEGLDKHL 708
Cdd:NF040716 481 DWILQFNQLTAERLLFYRCLAALLELTLDEERDPEDYRAALARMYGEETVDAAWGLIDGSVRFFGLTAGGLNLEGSQAHQ 560
                        570
                 ....*....|.
gi 498066271 709 RLIDSYKKLHA 719
Cdd:NF040716 561 RLLAAYQKLQK 571
YcaO_C pfam18381
YcaO cyclodehydratase C-terminal domain; This is the proline-rich C-terminal domain found in ...
552-723 2.19e-104

YcaO cyclodehydratase C-terminal domain; This is the proline-rich C-terminal domain found in ribosomal protein S12 methylthiotransferase accessory factor YcaO. It has been shown to be involved in both C protein recognition and cyclodehydration. The C-terminal domain resembles a tetratricopeptide repeat that mediates dimerization.


Pssm-ID: 465734  Cd Length: 172  Bit Score: 315.99  E-value: 2.19e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  552 ALQYREDILNIHSLEDEALADLVNRLEESQLDNYIDIITLIGVEFDENTVWGQLTILELKILIYLALGDIEAAIELVETF 631
Cdd:pfam18381   1 GLDLREDILNLHRLDDEQLLALLERLEESGLDDYTRVRELIGIEFDENTVWGTLRIGELKLLLALALGDLEEALEWVEWF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  632 LQYNDNTVERGLFYQAMHATLEVALDEELEIEDYIHSFTRMFGKEVMDAVIGSINGDVKFYGLTPTNMQLEGLDKHLRLI 711
Cdd:pfam18381  81 LQYNDNTAERGNFYRALNAVLEIALDDEREPADYEANFRRMFGEETVDAAWGSVEGEVRFYGLTPTDMKLEGLDAHQRLL 160
                         170
                  ....*....|..
gi 498066271  712 DSYKKLHAARAK 723
Cdd:pfam18381 161 ASYKKLQAAKAA 172
YhfA COG1765
Uncharacterized OsmC-related protein [General function prediction only];
7-127 2.49e-22

Uncharacterized OsmC-related protein [General function prediction only];


Pssm-ID: 441371  Cd Length: 126  Bit Score: 92.99  E-value: 2.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271   7 YLDNLRIDAKFDDFSVIADQPIRYKGDGSAPSPFDYFLASSALCAAYFVKVYCNARDIPTDGIRVAQNNIVDPENRYNQI 86
Cdd:COG1765    3 WEGGFRAEVETRGHTVVIDEPPELGGTDTGPSPVELLLAALAGCTAITVRMIAKKKGIDLEGLEVEVEGDRDEEPKGFTK 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 498066271  87 FKIQVELPESISEKDRQGILRSID-RCTVKKVIQTGPEFQVE 127
Cdd:COG1765   83 IRVTITVDGDLSEEQLERLLELAEkYCPVSDTLRNGVEITTE 124
OsmC_like_Se NF041052
OsmC-related (seleno)protein; Members of this family are distantly related to the ...
18-71 9.47e-05

OsmC-related (seleno)protein; Members of this family are distantly related to the hydroperoxide resistance protein OsmC (osmotically inducible protein) of Escherichia. Proteins found by the HMM include large numbers of selenoproteins, most of which currently are known only from Metagenome-Assembled Genomes (MAGs) of uncultured organisms, a large fraction of which are assigned to the Chloroflexi.


Pssm-ID: 468980  Cd Length: 144  Bit Score: 42.97  E-value: 9.47e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 498066271  18 DDFSVIADQPIRYKGDGSAPSPFDYFLASSALCAAYFVKVYCNARDIPTDGIRV 71
Cdd:NF041052  21 GKFTIACDEPPRLGGTDTAPSPLAYFAAGIAFULLTQLSRYAHMLKVPIDSAKV 74
 
Name Accession Description Interval E-value
TIGR03549 TIGR03549
YcaO domain protein; This family consists of remarkably well-conserved proteins from gamma and ...
2-718 0e+00

YcaO domain protein; This family consists of remarkably well-conserved proteins from gamma and beta Proteobacteria, heavily skewed towards organisms of marine environments. Its gene neighborhood is not conserved. This family has an OsmC-like N-terminal domain. It shares a YcaO domain, frequently associated with ATP-dependent cyclodehydration for peptide modification. The function is unknown. Fifteen of the first sixteen members of this family are from selenouridine-positive genomes, but this correlation may not be meaningful.


Pssm-ID: 132588 [Multi-domain]  Cd Length: 718  Bit Score: 1439.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271    2 EIKVNYLDNLRIDAKFDDFSVIADQPIRYKGDGSAPSPFDYFLASSALCAAYFVKVYCNARDIPTDGIRVAQNNIVDPEN 81
Cdd:TIGR03549   1 EIKVNFLDNLRLEAKFDDFTVIADQPIRYKGDGSAPGPFDYFLASSALCAAYFVKVYCNARDIPTENIRLSQNNIVDPED 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271   82 RYNQIFKIQVELPESISEKDRQGILRSIDRCTVKKVIQTGPEFQVEAVESLDDDAQAMLMVNTDSDASTFILGKDLPLEQ 161
Cdd:TIGR03549  81 RYNQIFKIQVELPEDISEKDRQGILRSIDRCTVKKVVQTGPEFQIETVENLDADAQALLMGTPDSGASTYIEGKDLPLEQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  162 TIANMTGILSDLGMKIEVASWRNIVPNVWSLHIRDAASPMCFTNGKGATKESALCSALGEFIERLNCNFFYNDQFFGEEI 241
Cdd:TIGR03549 161 TIANMTAILADLGMKIEIASWRNIVPNVWSLHIRDAASPMCFTNGKGATKESALCSALGEFIERLNCNFFYNDQFFGEDI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  242 ANAEFVHYPNEQWFKPGDNDELPAEILDGYTREIYDPEGELRGSNLIDTNSGNIERGICSIPYTRHSDGETVYFPSNLIE 321
Cdd:TIGR03549 241 ANSAFVHYPNEKWFKPGDDDALPAGILDEYCLAIYNPDGELRGSHLIDTNSGRTDRGICSLPFVRQSDGETVYFPSNLIE 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  322 NLFLSNGMSAGNNLFEAKVQCLSEIFERAVKKQIIEQEIVLPDVPEDVLAKFPGIVAGIKGLEEQGFPVVVKDASLGGQF 401
Cdd:TIGR03549 321 NLFLSNGMSAGNTLAEAQVQCLSEIFERAVKKEIIEEEIVLPDVPQEVLAKYPGILAGIKALEEQGFPVLVKDASLGGQF 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  402 PVMCVTLMNPKTGGVFASFGAHPSLEVALERSLTELLQGRSFEGLNDVPKPTFNSMAVSEPENFVEHFIDSTGVISWRFF 481
Cdd:TIGR03549 401 PVMCVTLMNPRTGGVFASFGAHPSFEVALERSLTELLQGRSFEGLNDLPQPTFNSMAVTEPNNFVEHFIDSSGVVSWRFF 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  482 SAKHDYEFVEWDFTGTNEEECDKLFAILKDLGKEAYIAEFTDMG-TACRILVPGYSEVYPAEDLIWDNTNKALQYREDIL 560
Cdd:TIGR03549 481 SAKHDYDFVEWDFSGTNEEEAATLFGILEDMGKEVYIAVYEDLGaPACRILVPGYSEVYPVEDLIWDNTNKALDYREDIL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  561 NIHSLEDEALADLVNRLEESQLDNYIDIITLIGVEFDENTVWGQLTILELKILIYLALGDIEAAIELVETFLQYNDNTVE 640
Cdd:TIGR03549 561 NLHRLDDEALEDLLERLEESQLDNYTDIRTLIGIEFDENTVWGQLTILELKLLIYLALQRHEDALELVGMFLQFNDNTVE 640
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 498066271  641 RGLFYQAMHATLEVALDEELEIEDYIHSFTRMFGKEVMDAVIGSINGDVKFYGLTPTNMQLEGLDKHLRLIDSYKKLH 718
Cdd:TIGR03549 641 RGLFYQAVNAVLEVTLDEELELEDYRRNFNRMYGEETMDAVIGSVNGSVRFYGLTPTSMKLEGLDRHLRLIESYKKLH 718
YcaO_for_S12 NF040716
30S ribosomal protein S12 methylthiotransferase accessory factor YcaO; YcaO acts as a partner ...
150-719 0e+00

30S ribosomal protein S12 methylthiotransferase accessory factor YcaO; YcaO acts as a partner for RimO to achieve the modification of ribosomal protein S12. Homologs of YcaO are involved a wide variety of RiPP (ribosomally translated, post-translationally modified peptide) natural product biosynthesis pathways. Some members of this family have an additional N-terminal OsmC-like domain.


Pssm-ID: 468680 [Multi-domain]  Cd Length: 571  Bit Score: 1074.52  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 150 TFILGKDLPLEQTIANMTGILSDLGMKIEVASWRNIVPNVWSLHIRDAASPMCFTNGKGATKESALCSALGEFIERLNCN 229
Cdd:NF040716   1 TFIPGKDAALEDSIANMQTKLQALGFNIEEASWLNPVPNVWSVHIRDRDCPMLFTNGKGASRKAALASALGEYFERLSTN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 230 FFYNDQFFGEEIANAEFVHYPNEQWFKPGDNDELPAEILDGYTREIYDPEGELRGSNLIDTNSGNIERGICSIPYTRHSD 309
Cdd:NF040716  81 YFFADYYLGEEIANADFVHYPNEKWFPLGDDDSLPEGLLDPELRAFYDPEGELTASDLIDLNSGNAERGICALPYVRQRD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 310 GETVYFPSNLIENLFLSNGMSAGNNLFEAKVQCLSEIFERAVKKQIIEQEIVLPDVPEDVLAKFPGIVAGIKGLEEQGFP 389
Cdd:NF040716 161 GETVYFPVNLIGNLYVSNGMSAGNTLAEARVQGLSEIFERAVKNRIIAEGICLPEVPEEVIARYPAIAAGIEALEAQGFP 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 390 VVVKDASLGGQFPVMCVTLMNPKTGGVFASFGAHPSLEVALERSLTELLQGRSFEGLNDVPKPTFNSMAVSEPENFVEHF 469
Cdd:NF040716 241 VLVKDASLGGQFPVMCVTLLNPKDGGCFASFGAHPRFEVALERTLTELLQGRSLDDLDGFPPPTFDLEEVAEPENLETHF 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 470 IDSTGVISWRFFSAKHDYEFVEWDFTGTNEEECDKLFAILKDLGKEAYIAEFTDMGT-ACRILVPGYSEVYPAEDLIWDN 548
Cdd:NF040716 321 IDSSGVISWDFFSDTPDYEFVDWDFSGTTEEEFDWLIAILHAEGKDVYIADYEHLGVyACRILVPGMSEIYPVEDLIWDN 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 549 TNKALQYREDILNIHSLEDEALADLVNRLEESQLDNYIDIITLIGVEFDENTVWGQLTILELKILIYLALGDIEAAIELV 628
Cdd:NF040716 401 NNVGLLLREALLNLPELDDEQYAELLDRLEESGLDDHQPVAELIGLAPDPGTVWGTLRIGELKLLLALALGDLEAALEWV 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 629 ETFLQYNDNTVERGLFYQAMHATLEVALDEELEIEDYIHSFTRMFGKEVMDAVIGSINGDVKFYGLTPTNMQLEGLDKHL 708
Cdd:NF040716 481 DWILQFNQLTAERLLFYRCLAALLELTLDEERDPEDYRAALARMYGEETVDAAWGLIDGSVRFFGLTAGGLNLEGSQAHQ 560
                        570
                 ....*....|.
gi 498066271 709 RLIDSYKKLHA 719
Cdd:NF040716 561 RLLAAYQKLQK 571
TIGR00702 TIGR00702
YcaO-type kinase domain; This protein family includes YcaO and homologs that can phosphorylate ...
159-548 1.43e-105

YcaO-type kinase domain; This protein family includes YcaO and homologs that can phosphorylate a peptide amide backbone (rather than side chains), as during heterocycle-forming modifications during maturation of the TOMM class (Thiazole/Oxazole-Modified Microcins) of bacteriocins. However, YcaO domain proteins also occur in contexts that do not suggest peptide modification. [Hypothetical proteins, Conserved]


Pssm-ID: 273224  Cd Length: 377  Bit Score: 327.19  E-value: 1.43e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  159 LEQTIANMTGILSDLGM-KIEVASWRNI--VPNVWSLHIRDAASPMCFTNGKGATKESALCSALGEFIERLNCNFFYNDQ 235
Cdd:TIGR00702   3 PEETIAAFQQKLSPIGFtGIEEITWLDClgIPVVWAVRPRDKDGALSISNGKGATKKAALASALMEAFERLSAEYFFADG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  236 ffgeeianaEFVHYPNEQWFkPGDNDELPAEILDGYTREIYDPEGELRGSNLIDTNSGNIERGICSIPYTRHSDGETVYF 315
Cdd:TIGR00702  83 ---------LFVAYPNDKWF-PLTDDPAPEGLILPSLYDAGVKLEWLTGETLIDLESGNVPAGAVFVPYARQSDWQTLFR 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  316 PSnlienlflSNGMSAGNNLFEAKVQCLSEIFERAVKKqiIEQEIVLPDVPEDVLAKFPGIVAG-IKGLEEQGFPVVVKD 394
Cdd:TIGR00702 153 PN--------TNGLASGNTRDEAILHGLSEVIERDAWS--LAEAARLPEIEVDVDDRYNSIIAHlIEKLEAAGVPIDLAD 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  395 ASLGGQFPVMCVTLMNPKTGGVFASFGAHPSLEVALERSLTELLQGRSFEGLNDVPKPTFNSMAVSEPENFVEHFIDSTG 474
Cdd:TIGR00702 223 LTLGGGYPVVAAVLDDPTLGTLFGGFGAHLDPEVALERALTEVAQSRATQIHGVREDPPFAIEEFAERANYERHKRDSSG 302
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498066271  475 VISWRFFSAKHDYEFVEWDFTGTNEEECDKLFAILKDLGKEAYIAEFTDMGT-ACRILVPGYsEVYPAEDLIWDN 548
Cdd:TIGR00702 303 WFSEDLIKRDTMYRFADWDFSGDLEEEAATLMAIGSGTEKLVYVDDYADVGVpAVRVIVPGM-EVYSADPLRLAR 376
YcaO_C pfam18381
YcaO cyclodehydratase C-terminal domain; This is the proline-rich C-terminal domain found in ...
552-723 2.19e-104

YcaO cyclodehydratase C-terminal domain; This is the proline-rich C-terminal domain found in ribosomal protein S12 methylthiotransferase accessory factor YcaO. It has been shown to be involved in both C protein recognition and cyclodehydration. The C-terminal domain resembles a tetratricopeptide repeat that mediates dimerization.


Pssm-ID: 465734  Cd Length: 172  Bit Score: 315.99  E-value: 2.19e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  552 ALQYREDILNIHSLEDEALADLVNRLEESQLDNYIDIITLIGVEFDENTVWGQLTILELKILIYLALGDIEAAIELVETF 631
Cdd:pfam18381   1 GLDLREDILNLHRLDDEQLLALLERLEESGLDDYTRVRELIGIEFDENTVWGTLRIGELKLLLALALGDLEEALEWVEWF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  632 LQYNDNTVERGLFYQAMHATLEVALDEELEIEDYIHSFTRMFGKEVMDAVIGSINGDVKFYGLTPTNMQLEGLDKHLRLI 711
Cdd:pfam18381  81 LQYNDNTAERGNFYRALNAVLEIALDDEREPADYEANFRRMFGEETVDAAWGSVEGEVRFYGLTPTDMKLEGLDAHQRLL 160
                         170
                  ....*....|..
gi 498066271  712 DSYKKLHAARAK 723
Cdd:pfam18381 161 ASYKKLQAAKAA 172
YcaO pfam02624
YcaO cyclodehydratase, ATP-ad Mg2+-binding; YcaO is an ATP- an Mg2+-binding protein involved ...
205-536 5.48e-73

YcaO cyclodehydratase, ATP-ad Mg2+-binding; YcaO is an ATP- an Mg2+-binding protein involved in the peptidic biosynthesis of azoline. There three motifs involved in the binding are, in UniProtKB:P75838, 71-79: Sx3ExxER, 184-203: Sx6Ex3Qx3ExxER, and 286-290: RxxxE. Three slightly different functional families are represented in this family, proteins involved in TOMM (thiazole/oxazole-modified microcin) biogenesis, non-TOMM proteins such as UniProtKB:P75838, and TfuA-associated non-TOMM proteins involved in trifolitoxin biosynthesis. UniProtKB:P75838 hydrolyses ATP to AMP and pyrophosphate.


Pssm-ID: 426884  Cd Length: 318  Bit Score: 239.49  E-value: 5.48e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  205 NGKGATKESALCSALGEFIERLNCNFFYndqffgeeianaefvhyPNEQWFKpGDNDELPAEILDGYTREIYDPEGELRG 284
Cdd:pfam02624   1 NGKGATPEQARASALMEAIERYSAGFFE-----------------GDEPRVR-GSYRELGERALDPETLGLYSPEQYAPD 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  285 snlIDTNSGNIERGICSIPYTRHSDGETVYFPSNLI---------ENLFL--SNGMSAGNNLFEAKVQCLSEIFERAVKK 353
Cdd:pfam02624  63 ---FVLEPFDPDRPIDWVPGWSLTDGEPVLVPANLVyypyppprgPRFFLytSNGLAAGNTLEEAILHGLLEVIERDAFA 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  354 QIIEQEIVLPDVPedvLAKFPGIVAGIKGLEEQGFPVVVKDASLGGQFPVMCVTLMN--PKTGGVFASFGAHPSLEVALE 431
Cdd:pfam02624 140 LWWYNRLPLPRID---LDSDPAIRELLDRLERAGIEVRLLDATLDLGIPVVAAVARDrdPPPALLVFGAGAHPDPEIALE 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271  432 RSLTELLQGRSF--EGLNDVPKPTFNSMAVSEPENFVEHFIDSTGVIswrffsAKHDYEFVEWDFTGTNEEECDKLFAIL 509
Cdd:pfam02624 217 RALTEAAQSRLTliHGAREDPDFDEDLRRVAGLEDHESYLWAPEAEP------VRADFLLFPPWASGDLEEDLETLLERL 290
                         330       340
                  ....*....|....*....|....*...
gi 498066271  510 KDLGKEAYIAEFTDMG-TACRILVPGYS 536
Cdd:pfam02624 291 AAAGLDVLVVDLTDLGlPVVRVIVPGLE 318
YhfA COG1765
Uncharacterized OsmC-related protein [General function prediction only];
7-127 2.49e-22

Uncharacterized OsmC-related protein [General function prediction only];


Pssm-ID: 441371  Cd Length: 126  Bit Score: 92.99  E-value: 2.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271   7 YLDNLRIDAKFDDFSVIADQPIRYKGDGSAPSPFDYFLASSALCAAYFVKVYCNARDIPTDGIRVAQNNIVDPENRYNQI 86
Cdd:COG1765    3 WEGGFRAEVETRGHTVVIDEPPELGGTDTGPSPVELLLAALAGCTAITVRMIAKKKGIDLEGLEVEVEGDRDEEPKGFTK 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 498066271  87 FKIQVELPESISEKDRQGILRSID-RCTVKKVIQTGPEFQVE 127
Cdd:COG1765   83 IRVTITVDGDLSEEQLERLLELAEkYCPVSDTLRNGVEITTE 124
YcaO COG1944
Ribosomal protein S12 methylthiotransferase accessory factor YcaO [Translation, ribosomal ...
158-534 5.24e-21

Ribosomal protein S12 methylthiotransferase accessory factor YcaO [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441547  Cd Length: 397  Bit Score: 95.78  E-value: 5.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 158 PLEQTIANMTGILSDLGMKIeVASWRNI----VPNVWSLHIRDAASP-MCFTNGKGATKESALCSALGEFIERlncnffy 232
Cdd:COG1944    3 SPEETLERVRPLLSPLGIGR-VADITGLdrlgIPVYSAVRPNARAAGaLSVSQGKGLTPEQARASALMEAIER------- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 233 ndqFFGEEIANAEFVHYPNEQWfkpGDNDEL--PAEILDGYTREIYDPEGELR---GSNLIDtnsgniergicsipytrh 307
Cdd:COG1944   75 ---YSAERQGDEPLVRASYAEL---GAEDRAldPEDLLLPSDESPFDPDRPIDwvpGWDLTS------------------ 130
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 308 sdGETVYFPSNLI----------ENLFL--SNGMSAGNNLFEAKVQCLSEIFER-----AVKKQIIEQEIVLPDVPEdvl 370
Cdd:COG1944  131 --GEPVLVPAEAVyypyplpppgPRFFRasSNGLAAGNTLEEAILHGLLELIERdafalWWYNRLPGPRIDLDSFDD--- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 371 akfPGIVAGIKGLEEQGFPVVVKDASLGGQFP-VMCVTL-MNPKTGGVFASFGAHPSLEVALERSLTELLQGRSF--EGL 446
Cdd:COG1944  206 ---PALRELLDRFRAAGIEVWLLDLTSDLGVPvVAAVARdPDGDPPLLAFGAGAHLDPEIALLRALTEAAQSRLTfiSGA 282
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271 447 NDVPKPTFNSMAVSEPENFVEHFIDSTGVISWRFFSAKHDYEfvewdfTGTNEEECDKLFAILKDLGKEAYIAEFT--DM 524
Cdd:COG1944  283 RDDLPAEYRRAADYERVRRLEDHAYLDASGPTVPFADLPDLS------TDDLREDLAALLDRLAAAGLDVLVVDLTrpDL 356
                        410
                 ....*....|.
gi 498066271 525 G-TACRILVPG 534
Cdd:COG1944  357 GlPVVRVIVPG 367
OsmC pfam02566
OsmC-like protein; Osmotically inducible protein C (OsmC) is a stress -induced protein found ...
32-127 2.59e-11

OsmC-like protein; Osmotically inducible protein C (OsmC) is a stress -induced protein found in E. Coli. This family also contains a organic hydroperoxide detoxification protein that has a novel pattern of oxidative stress regulation.


Pssm-ID: 460594  Cd Length: 99  Bit Score: 60.41  E-value: 2.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498066271   32 GDGSAPSPFDYFLASSALCAAYFVKVYCNARDIPTDGIRVAQNNIVDPE--NRYNQI-FKIQVELPESISEKDRQGILRS 108
Cdd:pfam02566   1 GDGSGPNPEELLLAALASCFAITLRAIAKKKGIKLEDLEVEVEGERDPEgaLGFTEIrLRVEVKTPDADEEKLKKLLELA 80
                          90
                  ....*....|....*....
gi 498066271  109 IDRCTVKKVIQTGPEFQVE 127
Cdd:pfam02566  81 EKKCPVANTLKNGIKVELE 99
OsmC_like_Se NF041052
OsmC-related (seleno)protein; Members of this family are distantly related to the ...
18-71 9.47e-05

OsmC-related (seleno)protein; Members of this family are distantly related to the hydroperoxide resistance protein OsmC (osmotically inducible protein) of Escherichia. Proteins found by the HMM include large numbers of selenoproteins, most of which currently are known only from Metagenome-Assembled Genomes (MAGs) of uncultured organisms, a large fraction of which are assigned to the Chloroflexi.


Pssm-ID: 468980  Cd Length: 144  Bit Score: 42.97  E-value: 9.47e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 498066271  18 DDFSVIADQPIRYKGDGSAPSPFDYFLASSALCAAYFVKVYCNARDIPTDGIRV 71
Cdd:NF041052  21 GKFTIACDEPPRLGGTDTAPSPLAYFAAGIAFULLTQLSRYAHMLKVPIDSAKV 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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