|
Name |
Accession |
Description |
Interval |
E-value |
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
130-422 |
3.27e-33 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 127.33 E-value: 3.27e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 130 VILVSLIDEIEITSEEFILVVAMVLSIVAVLVFLFGSLLLRLSQRLIEPVNALKTQLDHHQGDATQTFSVPEGSAKEFQT 209
Cdd:COG0642 12 LLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 210 LADELNEYRHKINQVIKREQAFARYASHELRTPLTVMKGSSSLLARSANTDfQTRQVNRIQDATQQMSTMVDALLGLVRY 289
Cdd:COG0642 92 LLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEE-QREYLETILRSADRLLRLINDLLDLSRL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 290 ERNADDSPVRSIT-EEELNQIIFQSQAQADEKALSFDVQIDGNPRTRATNAV-LTIILGNLIRNGIAATPSGS---IHIN 364
Cdd:COG0642 171 EAGKLELEPEPVDlAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDrLRQVLLNLLSNAIKYTPEGGtvtVSVR 250
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497392732 365 MDEN--TISVRDEGEG------------FSTIPHS---DGHGLGLMIVDDLCQRYGWQFKIGTHPEGGCEAVIDL 422
Cdd:COG0642 251 REGDrvRISVEDTGPGippedlerifepFFRTDPSrrgGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
213-422 |
5.83e-29 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 113.46 E-value: 5.83e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 213 ELNEYRHKINQVIKREQAFARYASHELRTPLTVMKGSSSLLARSANTDFQTRQ--VNRIQDATQQMSTMVDALLGLVRYE 290
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRelLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 291 RNADDSPVRSIT-EEELNQIIFQSQAQADEKALSFDVQIDGNPRTRATNAV-LTIILGNLIRNGIAATPSGS-IHINMDE 367
Cdd:COG2205 81 SGKLSLELEPVDlAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPElLEQVLANLLDNAIKYSPPGGtITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497392732 368 N----TISVRDEGEGFS---------------TIPHSDGHGLGLMIVDDLCQRYGWQFKIGTHPEGGCEAVIDL 422
Cdd:COG2205 161 EgdgvRISVSDNGPGIPeeeleriferfyrgdNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
130-422 |
5.74e-26 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 108.49 E-value: 5.74e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 130 VILVSLIDEIEITSEEFILVVAMVLSIVAVLVFLFGSLLLRLSQRLIEPVNALKTQLDHHQGDATQTFSVPEGSAKEFQT 209
Cdd:COG5002 64 LLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 210 LADELNEYRHKINQVIKREQA---FARYASHELRTPLTVMKGSSSLLARSANTDFQTRQ--VNRIQDATQQMSTMVDALL 284
Cdd:COG5002 144 GLLLLAAVERDITELERLEQMrreFVANVSHELRTPLTSIRGYLELLLDGAADDPEERReyLEIILEEAERLSRLVNDLL 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 285 GLVRYERNADDSPVRSIT-EEELNQIIFQSQAQADEKALSFDVQI-DGNPRTRATNAVLTIILGNLIRNGIAATPSGS-I 361
Cdd:COG5002 224 DLSRLESGELKLEKEPVDlAELLEEVVEELRPLAEEKGIELELDLpEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGtI 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 362 HINMDEN----TISVRDEGEGFST--IPH---------------SDGHGLGLMIVDDLCQRYGWQFKIGTHPEGGCEAVI 420
Cdd:COG5002 304 TVSLREEddqvRISVRDTGIGIPEedLPRiferfyrvdksrsreTGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTI 383
|
..
gi 497392732 421 DL 422
Cdd:COG5002 384 TL 385
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
178-420 |
3.35e-21 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 95.49 E-value: 3.35e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 178 PVNALKTQLDHHQGDATQTFSVpEGSAKEFQTLADELNEYRHKINQVIKREQAFARYASHELRTPLTVMKGSSSlLARSA 257
Cdd:PRK10337 188 PLKKLALALRMRDPDSETPLNA-TGVPSEVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTE-VAQLS 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 258 NTDFQTRqvnriQDATQQMST-------MVDALLGLVRYERNADDSPVRSITEEELNQ---IIFQSQAQADEKALSFDVQ 327
Cdd:PRK10337 266 DDDPQAR-----KKALLQLHAgidratrLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQsavMDIYHTAQQAGIDVRLTLN 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 328 IDGNPRTrATNAVLTIILGNLIRNGIAATPSGS-IHINMDENTISVRDEGEGFSTI-----------P---HSDGHGLGL 392
Cdd:PRK10337 341 AHPVIRT-GQPLLLSLLVRNLLDNAIRYSPQGSvVDVTLNARNFTVRDNGPGVTPEalarigerfyrPpgqEATGSGLGL 419
|
250 260
....*....|....*....|....*...
gi 497392732 393 MIVDDLCQRYGWQFKIGTHPEGGCEAVI 420
Cdd:PRK10337 420 SIVRRIAKLHGMNVSFGNAPEGGFEAKV 447
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
195-422 |
3.86e-18 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 86.44 E-value: 3.86e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 195 QTFSVPEGSAKEFQTLADELNEYRHKI---NQVIKREQAFAryasHELRTPLTVMKGSSSLLARSANTDFQTRQVNRIQD 271
Cdd:PRK11100 224 KPVPLPKLGSSELRELAQALESMRVKLegkAYVEQYVQTLT----HELKSPLAAIRGAAELLQEDPPPEDRARFTGNILT 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 272 ATQQMSTMVDALLGLVRYE-RNADDSPVRSITEEELNQIIFQSQAQADEKALSFDVQIDGNpRTRATNAVLTIILGNLIR 350
Cdd:PRK11100 300 QSARLQQLIDRLLELARLEqRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDDA-RVLGDPFLLRQALGNLLD 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 351 NGIAATPSGS-IHINMDENT----ISVRDEGEG------------FSTIPHSDGH----GLGLMIVDDLCQRYGWQFKIG 409
Cdd:PRK11100 379 NAIDFSPEGGtITLSAEVDGeqvaLSVEDQGPGipdyalpriferFYSLPRPANGrkstGLGLAFVREVARLHGGEVTLR 458
|
250
....*....|...
gi 497392732 410 THPEGGCEAVIDL 422
Cdd:PRK11100 459 NRPEGGVLATLTL 471
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
236-429 |
1.19e-17 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 84.63 E-value: 1.19e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 236 SHELRTPLTVMKGSSSLLAR------SANTDFQTRQVNRIQDATQQMSTMVDALLGLVRyernaddSPVRSITEEELNQI 309
Cdd:COG5000 209 AHEIKNPLTPIQLSAERLRRkladklEEDREDLERALDTIIRQVDRLKRIVDEFLDFAR-------LPEPQLEPVDLNEL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 310 I----FQSQAQADEKALSFDVQIDGN-PRTRATNAVLTIILGNLIRNGIAATPS-GSIHINMDEN----TISVRDEGEGF 379
Cdd:COG5000 282 LrevlALYEPALKEKDIRLELDLDPDlPEVLADRDQLEQVLINLLKNAIEAIEEgGEIEVSTRREdgrvRIEVSDNGPGI 361
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497392732 380 S-------TIPH----SDGHGLGLMIVDDLCQRYGWQFKIGTHPEGGCEAVIDLASEHQEA 429
Cdd:COG5000 362 PeevleriFEPFfttkPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
235-415 |
3.89e-17 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 81.87 E-value: 3.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 235 ASHELRTPLTVMKGSSSLLARSANTDFQTRQ--VNRIQDATQQMSTMVDALLGLVRYERNADD--------SPVRSITEE 304
Cdd:TIGR02966 121 VSHELRTPLTVLRGYLETLADGPDEDPEEWNraLEIMLEQSQRMQSLVEDLLTLSRLESAASPledepvdmPALLDHLRD 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 305 ELNQIifqsqaqADEKALSFDVQIDGNPRTRATNAVLTIILGNLIRNGIAATPSG---SIHINMDEN--TISVRDEGEGF 379
Cdd:TIGR02966 201 EAEAL-------SQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYTPEGgtiTVRWRRDGGgaEFSVTDTGIGI 273
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 497392732 380 ST--IPH---------------SDGHGLGLMIVDDLCQRYGWQFKIGTHPEGG 415
Cdd:TIGR02966 274 APehLPRlterfyrvdksrsrdTGGTGLGLAIVKHVLSRHHARLEIESELGKG 326
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
37-405 |
6.46e-15 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 76.36 E-value: 6.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 37 LITGSLLWSEDRVGERRIMVDKKEAIEHFQSHPEQGSIQLDLLTTAYNDISLVAERYQKYLIGQKHFLDEVEDGEYSRMV 116
Cdd:COG4251 91 LVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILAL 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 117 YMSTYTYKGVEHPVILVSLIDEIEITSEEFILVVAMVLSIVAVLVFLFGSLLLRLSQRLIEPVNALKTQLDHHQGDATQT 196
Cdd:COG4251 171 LLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLIL 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 197 FSVPEGSAKEFQTLADELNEYRHKINQVIKREQAFARYASHELRTPLTVMKGSSSLLARSANTDFQT---RQVNRIQDAT 273
Cdd:COG4251 251 VLELLELRLELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEDYGDKLDEegrEYLERIRDAA 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 274 QQMSTMVDALLGLVRYERNADD-SPVRsiTEEELNQIIFQSQAQADEKAlsFDVQIDGNPRTRATNAVLTIILGNLIRNG 352
Cdd:COG4251 331 ERMQALIDDLLAYSRVGRQELEfEPVD--LNELLEEVLEDLEPRIEERG--AEIEVGPLPTVRGDPTLLRQVFQNLISNA 406
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497392732 353 I---AATPSGSIHINMDEN----TISVRDEGEG------------FSTIPHSD---GHGLGLMIVDDLCQRYGWQ 405
Cdd:COG4251 407 IkysRPGEPPRIEIGAEREggewVFSVRDNGIGidpeyaekifeiFQRLHSRDeyeGTGIGLAIVKKIVERHGGR 481
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
126-422 |
6.34e-13 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 69.83 E-value: 6.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 126 VEHPVILVSLIDEIEITSEEFILVVAMVLSIVAVLVFLFGSLLLRLSQRLIEPVNALKTQLDHHQGDATQTFSVPEGSAK 205
Cdd:COG4191 35 LLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELER 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 206 EFQTLADELNEYRHKINQVIKREqafaRYAS---------HELRTPLTVMKGSSSLLARSANTDFQTRQV----NRIQDA 272
Cdd:COG4191 115 DITELERAEEELRELQEQLVQSE----KLAAlgelaagiaHEINNPLAAILGNAELLRRRLEDEPDPEELrealERILEG 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 273 TQQMSTMVDALLGLVRyERNADDSPVrsiteeELNQIIFQS----QAQADEKALSFDVQIDGN-PRTRATNAVLTIILGN 347
Cdd:COG4191 191 AERAAEIVRSLRAFSR-RDEEEREPV------DLNELIDEAlellRPRLKARGIEVELDLPPDlPPVLGDPGQLEQVLLN 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 348 LIRNGIAATPSGS-----IHINMDEN--TISVRDEGEG-------------FSTIPHSDGHGLGLMIVDDLCQRYGWQFK 407
Cdd:COG4191 264 LLINAIDAMEEGEggritISTRREGDyvVISVRDNGPGippevlerifepfFTTKPVGKGTGLGLSISYGIVEKHGGRIE 343
|
330
....*....|....*
gi 497392732 408 IGTHPEGGCEAVIDL 422
Cdd:COG4191 344 VESEPGGGTTFTITL 358
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
231-290 |
7.23e-13 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 63.38 E-value: 7.23e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 231 FARYASHELRTPLTVMKGSSSLLARSANTDFQTRQVNRIQDATQQMSTMVDALLGLVRYE 290
Cdd:pfam00512 5 FLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIE 64
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
14-395 |
1.23e-12 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 69.34 E-value: 1.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 14 SMTGRLALFFSFVSVVIgifcFLLITGSLLWSEDRVGERR---IMVDKKEAIEHF-------QSHPEQGSIQLDLLTTAY 83
Cdd:TIGR01386 3 SLTLRLALLFAAVTALV----FALSGFMLYSSLERHFEERdreELQGKLEQVRRFlrdpadlDEDIKRLQEKIDDLLVGH 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 84 NDISL---------VAERYQKYLI--------GQKHFLDEVEDGEYSRMVYMS---TYTYKGVEHPVILVSLideiEITS 143
Cdd:TIGR01386 79 SDLALsilnpdgrlLFERAQGAALvpavaandALLELDQADAKMTHYRSILRSvaaLPGGKGRKPVQITVAL----DINA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 144 EEFIL--VVAMVLSIVAVLVFLFGSLLLRLSQRLIEPVNALKTQLDH-HQGDATQTFSVPEGSAkEFQTLADELNEYRHK 220
Cdd:TIGR01386 155 HTHLLdaLRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARiSPESLDQRLDPSRAPA-ELRELAQSFNAMLGR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 221 INQVIKREQAFARYASHELRTPLTvmkgssSLLARSANTDFQTRQVNRIQDAT-------QQMSTMVDALLGLVRYErNA 293
Cdd:TIGR01386 234 LEDAFQRLSQFSADLAHELRTPLT------NLLGQTQVALSQPRTGEEYREVLesnleelERLSRMVSDMLFLARAD-NG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 294 DDSPVRSITE--EELNQIIFQSQAQADEKALSFDVQidGNPRTRATNAVLTIILGNLIRNGIAATPSGS---IHI--NMD 366
Cdd:TIGR01386 307 QLALERVRLDlaAELAKVAEYFEPLAEERGVRIRVE--GEGLVRGDPQMFRRAISNLLSNALRHTPDGGtitVRIerRSD 384
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 497392732 367 ENTISVRDEGEGfstIP--------------------HSDGHGLGLMIV 395
Cdd:TIGR01386 385 EVRVSVSNPGPG---IPpehlsrlfdrfyrvdparsnSGEGTGLGLAIV 430
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
225-288 |
2.69e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 61.46 E-value: 2.69e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497392732 225 IKREQAFARYASHELRTPLTVMKGSSSLLARSA-NTDFQTRQVNRIQDATQQMSTMVDALLGLVR 288
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELlDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
229-288 |
4.21e-12 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 61.04 E-value: 4.21e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 229 QAFARYASHELRTPLTVMKGSSSLLARSANTDFQTRQVNRIQDATQQMSTMVDALLGLVR 288
Cdd:smart00388 3 REFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSR 62
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
206-415 |
3.11e-11 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 64.48 E-value: 3.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 206 EFQTLADELNEYRHKINQVikREQAfaryasHELRTPLTVMKGsssLLarsantdfqtrQVNRIQDATQQMSTMVDALlg 285
Cdd:COG3290 175 ELERLEEELEGVKELAEAL--RAQR------HDFRNHLHTISG---LL-----------QLGEYDEALEYIDEISEEL-- 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 286 lvryeRNADDSPVRSITEEELNQIIFQSQAQADEKALSFDVQIDGN-PRTRATNAVLTIILGNLIRNGIAAT-----PSG 359
Cdd:COG3290 231 -----QELIDSLLSRIGNPVLAALLLGKAARARERGIDLTIDIDSDlPDLPLSDTDLVTILGNLLDNAIEAVeklpeEER 305
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497392732 360 SIHINM----DENTISVRDEG-------------EGFSTiPHSDGHGLGLMIVDDLCQRYGWQFKIGTHPEGG 415
Cdd:COG3290 306 RVELSIrddgDELVIEVEDSGpgipeellekifeRGFST-KLGEGRGLGLALVKQIVEKYGGTIEVESEEGEG 377
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
176-425 |
4.83e-11 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 63.83 E-value: 4.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 176 IEPVNALKTQLDHHQGDATQTFSVpEGSAKEFQTLADELNEYRHKINQVIKREQAFARYASHELRTPLTVMKGSSSLLAR 255
Cdd:PRK10755 86 TRPLAELQKELEARTADNLTPIAI-HSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLELLEK 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 256 SANTDFQTrQVNRIqdatQQMSTMVDALLGLVR---------YERNADDSPVRSITEEELNQIIFQSQAQADEKALSFDV 326
Cdd:PRK10755 165 QHHIDVAP-LIARL----DQMMHTVEQLLQLARagqsfssghYQTVKLLEDVILPSQDELSEMLEQRQQTLLLPESAADI 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 327 QIDGNprtrATnaVLTIILGNLIRNGIAATPSGS---IHINMDEN--TISVRDEGEGfstIPHSD--------------- 386
Cdd:PRK10755 240 TVQGD----AT--LLRLLLRNLVENAHRYSPEGStitIKLSQEDGgaVLAVEDEGPG---IDESKcgelskafvrmdsry 310
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 497392732 387 -GHGLGLMIVDDLCQRYGWQFKIGTHPE-GGCEAVIDLASE 425
Cdd:PRK10755 311 gGIGLGLSIVSRITQLHHGQFFLQNRQErSGTRAWVWLPKA 351
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
206-404 |
6.49e-11 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 63.80 E-value: 6.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 206 EFQTLADELNEYRHKINQVIKREQAFARYASHELRTPLTVMKGSSSLLARSANtdfQTRQVNRIQDATQQMSTMVDALLG 285
Cdd:PRK09470 221 EFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLATALLRRRQG---ESKELERIETEAQRLDSMINDLLV 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 286 LVRYERNA----DDSPVRSITEEELNQIIFqsQAQADEKALSFDVQ-----IDGNPrtratnAVLTIILGNLIRNGIAAT 356
Cdd:PRK09470 298 LSRNQQKNhlerETFKANSLWSEVLEDAKF--EAEQMGKSLTVSAPpgpwpINGNP------NALASALENIVRNALRYS 369
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497392732 357 PSG-SIHINMDEN--TISVRDEGEGFST-----I--P----------HSDGHGLGLMIVDD-LCQRYGW 404
Cdd:PRK09470 370 HTKiEVAFSVDKDglTITVDDDGPGVPEeereqIfrPfyrvdeardrESGGTGLGLAIVENaIQQHRGW 438
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
341-422 |
1.45e-10 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 58.15 E-value: 1.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 341 LTIILGNLIRNGI-AATPSGSIHINM---DENTISVRDEGEG------------FSTIPHSD--GHGLGLMIVDDLCQRY 402
Cdd:pfam02518 6 LRQVLSNLLDNALkHAAKAGEITVTLsegGELTLTVEDNGIGippedlprifepFSTADKRGggGTGLGLSIVRKLVELL 85
|
90 100
....*....|....*....|
gi 497392732 403 GWQFKIGTHPEGGCEAVIDL 422
Cdd:pfam02518 86 GGTITVESEPGGGTTVTLTL 105
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
341-422 |
2.02e-10 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 57.66 E-value: 2.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 341 LTIILGNLIRNGIAATPS-GSIHINM----DENTISVRDEGEGFS----------------TIPHSDGHGLGLMIVDDLC 399
Cdd:smart00387 6 LRQVLSNLLDNAIKYTPEgGRITVTLerdgDHVEITVEDNGPGIPpedlekifepffrtdkRSRKIGGTGLGLSIVKKLV 85
|
90 100
....*....|....*....|...
gi 497392732 400 QRYGWQFKIGTHPEGGCEAVIDL 422
Cdd:smart00387 86 ELHGGEISVESEPGGGTTFTITL 108
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
213-401 |
2.78e-10 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 62.49 E-value: 2.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 213 ELNEYRHKINQVIK-----REQA---------FARYASHELRTPLTVMKGSSSLLARSANTDFQTRQVNRIQDATQQMST 278
Cdd:TIGR02956 435 ELAETNERLNAEVKnhakaRAEAeeanraksaFLATMSHEIRTPLNGILGTLELLGDTGLTSQQQQYLQVINRSGESLLD 514
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 279 MVDALLGLVRYER-NADDSP----VRSITEEELNqiIFQSQAQADEKALSFDV--------QIDGnPRTRAtnavltiIL 345
Cdd:TIGR02956 515 ILNDILDYSKIEAgHLSISPrpfdLNALLDDVHH--LMVSRAQLKGIQLRLNIpeqlpnwwQGDG-PRIRQ-------VL 584
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497392732 346 GNLIRNGIAATPSGSIHINMDEN-----TISVRDEGEG------------FSTIP---HSDGHGLGLMIvddlCQR 401
Cdd:TIGR02956 585 INLVGNAIKFTDRGSVVLRVSLNddsslLFEVEDTGCGiaeeeqatlfdaFTQADgrrRSGGTGLGLAI----SQR 656
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
204-416 |
2.26e-09 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 59.66 E-value: 2.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 204 AKEFQTLADELNE-YRHKINQVIKR-----------EQAFARYA------SHELRTPLTVMKGSSSLLARSANTDFQTRQ 265
Cdd:PRK15347 356 AKAYNQLLDTLNEqYDTLENKVAERtqalaeakqraEQANKRKSehlttiSHEIRTPLNGVLGALELLQNTPLTAEQMDL 435
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 266 VNRIQDATQQMSTMVDALLGLVRYErnaDDSPVRSITEEELNQIIFQS----QAQADEKALSFDVQIDGN-PRTRATNAV 340
Cdd:PRK15347 436 ADTARQCTLSLLAIINNLLDFSRIE---SGQMTLSLEETALLPLLDQAmltiQGPAQSKSLTLRTFVGAHvPLYLHLDSL 512
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 341 -LTIILGNLIRNGIAATPSGSI--HINMDENT--ISVRDEGEG-------------FSTIPHSDGHGLGLMIVDDLCQRY 402
Cdd:PRK15347 513 rLRQILVNLLGNAVKFTETGGIrlRVKRHEQQlcFTVEDTGCGidiqqqqqiftpfYQADTHSQGTGLGLTIASSLAKMM 592
|
250
....*....|....*
gi 497392732 403 GWQFKIGTHP-EGGC 416
Cdd:PRK15347 593 GGELTLFSTPgVGSC 607
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
237-403 |
1.59e-08 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 56.01 E-value: 1.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 237 HELRTPLTVMKGSSSLLARSANTDFQTRQVNRIQDATQQMSTMVDALLGLVRYERnaddsPVRSIT--EEELNQIIFQSQ 314
Cdd:COG3852 144 HEIRNPLTGIRGAAQLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRP-----PEREPVnlHEVLERVLELLR 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 315 AQADeKALSFDVQIDGN-PRTRA-----TNAVLtiilgNLIRNGIAATPS-GSIHI---NMDENT-----------ISVR 373
Cdd:COG3852 219 AEAP-KNIRIVRDYDPSlPEVLGdpdqlIQVLL-----NLVRNAAEAMPEgGTITIrtrVERQVTlgglrprlyvrIEVI 292
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 497392732 374 DEGEG-------------FSTipHSDGHGLGLMIVDDLCQRYG 403
Cdd:COG3852 293 DNGPGipeeildrifepfFTT--KEKGTGLGLAIVQKIVEQHG 333
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
237-394 |
4.46e-08 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 55.12 E-value: 4.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 237 HELRTPLTVMKGSSSLLARSANTDFQTRQVnrIQDATQQMSTMVDALLGLvryernADDSPVrSITEEELNQII------ 310
Cdd:COG5805 296 HEIRNPLTSIKGFLQLLQPGIEDKEEYFDI--MLSELDRIESIISEFLAL------AKPQAV-NKEKENINELIqdvvtl 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 311 FQSQAQADEKALSFD-------VQIDGNPrtratnavLTIILGNLIRNGIAATPSG---SIHINMDENTISVR--DEGEG 378
Cdd:COG5805 367 LETEAILHNIQIRLElldedpfIYCDENQ--------IKQVFINLIKNAIEAMPNGgtiTIHTEEEDNSVIIRviDEGIG 438
|
170 180 190
....*....|....*....|....*....|
gi 497392732 379 fstIPHS--------------DGHGLGLMI 394
Cdd:COG5805 439 ---IPEErlkklgepffttkeKGTGLGLMV 465
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
204-414 |
8.37e-08 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 54.36 E-value: 8.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 204 AKEFQTLADELNEYRHKInqvikreQAFARYASHELRTPLTVMKGSSSLLARSANTDFQTRQVNRIQDATQQMSTMVDAL 283
Cdd:TIGR03785 468 SRSFAQMVARLRQYTHYL-------ENMSSRLSHELRTPVAVVRSSLENLELQALEQEKQKYLERAREGTERLSMILNNM 540
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 284 LGLVRYERNADDSPVRSIteeELNQII--FQSQAQADEKALSFDVQIDGNPRT-RATNAVLTIILGNLIRNGIAATPSGS 360
Cdd:TIGR03785 541 SEATRLEQAIQSAEVEDF---DLSEVLsgCMQGYQMTYPPQRFELNIPETPLVmRGSPELIAQMLDKLVDNAREFSPEDG 617
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497392732 361 I-----HINMDENTISVRDEGegfSTIPHSDG-------------------H-GLGLMIVDDLCQRYGWQFKIGTHPEG 414
Cdd:TIGR03785 618 LievglSQNKSHALLTVSNEG---PPLPEDMGeqlfdsmvsvrdqgaqdqpHlGLGLYIVRLIADFHQGRIQAENRQQN 693
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
227-395 |
1.06e-07 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 53.86 E-value: 1.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 227 REQAFARyASHELRTPLTVMKGSSSLLARSA-NTDFQTRQVNRIQDATQQMSTMVDALLGLVRYErnaddspvrSITEEE 305
Cdd:PRK11006 204 RRNFFAN-VSHELRTPLTVLQGYLEMMQDQPlEGALREKALHTMREQTQRMEGLVKQLLTLSKIE---------AAPTID 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 306 LNQI--------IFQSQAQA---DEKALSFDVqiDGNPRTRATNAVLTIILGNLIRNGIAATPSGSiHINMD-ENT---- 369
Cdd:PRK11006 274 LNEKvdvpmmlrVLEREAQTlsqGKHTITFEV--DNSLKVFGNEDQLRSAISNLVYNAVNHTPEGT-HITVRwQRVpqga 350
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 497392732 370 -ISVRDEGEGFST--IP---------------HSDGHGLGLMIV 395
Cdd:PRK11006 351 eFSVEDNGPGIAPehIPrlterfyrvdkarsrQTGGSGLGLAIV 394
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
236-395 |
3.22e-07 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 52.28 E-value: 3.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 236 SHELRTPLTVMKGSSSLLARSANTDFQT------RQVNRIQDatqqmstMVDALLGL-----VRYERNaddsPVRSItee 304
Cdd:COG5809 278 AHEIRNPLTSLKGFIQLLKDTIDEEQKTyldimlSELDRIES-------IISEFLVLakpqaIKYEPK----DLNTL--- 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 305 eLNQIIFQSQAQADEKalsfDVQIdgnprTRATNAVLTIILG----------NLIRNGIAATPSG---SIHINMDENT-- 369
Cdd:COG5809 344 -IEEVIPLLQPQALLK----NVQI-----ELELEDDIPDILGdenqlkqvfiNLLKNAIEAMPEGgniTIETKAEDDDkv 413
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 497392732 370 -ISVRDEGEGfstIPHSD--------------GHGLGLMIV 395
Cdd:COG5809 414 vISVTDEGCG---IPEERlkklgepfyttkekGTGLGLMVS 451
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-420 |
4.35e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 48.23 E-value: 4.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 341 LTIILGNLIRNGIAATPSG---SIHINMDENTIS--VRDEGEGFS---------------TIPHSDGH-GLGLMIVDDLC 399
Cdd:cd16975 5 LSRALINIISNACQYAPEGgtvSISIYDEEEYLYfeIWDNGHGFSeqdlkkalelfyrddTSRRSGGHyGMGLYIAKNLV 84
|
90 100
....*....|....*....|.
gi 497392732 400 QRYGWQFKIGTHPEGGCEAVI 420
Cdd:cd16975 85 EKHGGSLIIENSQKGGAEVTV 105
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
236-422 |
1.77e-06 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 50.17 E-value: 1.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 236 SHELRTPLTVMKGSSSLLARSANTDFQTRQVNRIQ-DATQQMSTMVDALLGLVRYERNAdDSPVRsiteeeLNQIIFQS- 313
Cdd:PRK10364 245 AHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMaKEADRLNRVVSELLELVKPTHLA-LQAVD------LNDLINHSl 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 314 -----QAQADEKALSFDVQiDGNPRTRATNAVLTIILGNLIRNGIAATPS-GSIHINMDEN----TISVRDEGEG----- 378
Cdd:PRK10364 318 qlvsqDANSREIQLRFTAN-DTLPEIQADPDRLTQVLLNLYLNAIQAIGQhGVISVTASESgagvKISVTDSGKGiaadq 396
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 497392732 379 --------FSTipHSDGHGLGLMIVDDLCQRYGWQFKIGTHPEGGCEAVIDL 422
Cdd:PRK10364 397 leaiftpyFTT--KAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWL 446
|
|
| HATPase_c_5 |
pfam14501 |
GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
341-403 |
2.12e-06 |
|
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 46.05 E-value: 2.12e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497392732 341 LTIILGNLIRNGIAA---TPSGS-IHINMD----------ENTIS--VRDEGEGFSTIPHSDGHGLGLMIVDDLCQRYG 403
Cdd:pfam14501 6 LCVIFGNLLDNAIEAcskIDDNRfIRLKIRekqnfliiriENTYEgeLKFEGKLPSTKTKGDGHGIGLKSIRRIVKKYG 84
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
148-422 |
1.21e-05 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 47.51 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 148 LVVAMVLSIVAVLVFLFGSLLLRLSQRLIEPVNALKtqldhhQGD-ATQtfsVPEGSAKEFQTLADELNEYRHKINQVIK 226
Cdd:NF012163 168 LIVALALLLAALAAFLLARGLLAPVKRLVEATHRLA------AGDyTTR---VTPTSNDELGKLAQDFNQLASTLEKNEQ 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 227 REQAFARYASHELRTPLTVMKGsssllarsantdfqtrQVNRIQDATQQMS-TMVDALLGlvryernaddsPVRSITE-- 303
Cdd:NF012163 239 MRRDFMADISHELRTPLAVLRA----------------ELEAIQDGIRKFTpESLDSLQA-----------EVGTLTKlv 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 304 EELNQIifqsqAQADEKALSFDV----------QIDGNPRTRATNAVLTI-------------------ILGNLIRNGIA 354
Cdd:NF012163 292 DDLHDL-----SMSDEGALAYQKasvdlvplleVEGGAFRERFASAGLELevslpdsslvfgdrdrlmqLFNNLLENSLR 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 355 ATPS-GSIHIN-----------MDENTISVRDE-----GEGF-----STIPHSDGHGLGLMIVDDLCQRYGWQFKIGTHP 412
Cdd:NF012163 367 YTDSgGSLHISasqrpkevtltVADSAPGVSDEqlarlFERFyrvevSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSP 446
|
330
....*....|
gi 497392732 413 EGGCEAVIDL 422
Cdd:NF012163 447 LGGLRIVVTL 456
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-422 |
1.42e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 43.93 E-value: 1.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 325 DVQIDGNPrtratnAVLTIILGNLIRNGIAATPSGS-IHI---NMDENTISVRDEGEG------------FSTIP--HSD 386
Cdd:cd16940 4 DIQVQGDA------LLLFLLLRNLVDNAVRYSPQGSrVEIklsADDGAVIRVEDNGPGideeelealferFYRSDgqNYG 77
|
90 100 110
....*....|....*....|....*....|....*.
gi 497392732 387 GHGLGLMIVDDLCQRYGWQFKIGTHPEGGCEAVIDL 422
Cdd:cd16940 78 GSGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
236-422 |
1.83e-05 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 46.83 E-value: 1.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 236 SHELRTPLT-------VMKGSSSLLARSANTDfqtrqvnriqdaTQQMSTMVDALLGLVRYERNAddspvrSITEEELNQ 308
Cdd:PRK09467 237 SHDLRTPLTrirlateMMSEEDGYLAESINKD------------IEECNAIIEQFIDYLRTGQEM------PMEMADLNA 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 309 IIFQS-QAQAD-EKALSFDVQ-----IDGNPRtrATNAVLTIILGNLIRNGiaatpSGSIHIN--MDENT--ISVRDEGE 377
Cdd:PRK09467 299 LLGEViAAESGyEREIETALQpgpieVPMNPI--AIKRALANLVVNAARYG-----NGWIKVSsgTEGKRawFQVEDDGP 371
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 378 GF--STIPH-------------SDGHGLGLMIVDDLCQRYGWQFKIGTHPEGGCEAVIDL 422
Cdd:PRK09467 372 GIppEQLKHlfqpftrgdsargSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWL 431
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-420 |
2.23e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 43.77 E-value: 2.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 344 ILGNLIRNGIAATPSG---SIHINMDENTISVRDEGEGfstIPHSD----------------GHGLGLMIVDDLCQRYGW 404
Cdd:cd16954 41 LLGNLLDNACKWCLEFvevTARQTDGGLHLIVDDDGPG---VPESQrskifqrgqrldeqrpGQGLGLAIAKEIVEQYGG 117
|
90
....*....|....*.
gi 497392732 405 QFKIGTHPEGGCEAVI 420
Cdd:cd16954 118 ELSLSDSPLGGARFEV 133
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
306-403 |
2.68e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 43.72 E-value: 2.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 306 LNQIIFQSQAQADEKALSFDVQIDGNPRTRATNAVLTIILGNLIRNGIAA-----TPSGSIHINMD----------ENTI 370
Cdd:cd16935 2 LDSLLSEKLELAREKGIEFTIEIDIPILLPISPLDLCIIFGNLLDNAIEAcakidKENRFIHLKIRqkkgfliisiENSY 81
|
90 100 110
....*....|....*....|....*....|....*.
gi 497392732 371 S---VRDEGEGFSTIPHSdGHGLGLMIVDDLCQRYG 403
Cdd:cd16935 82 EgelKKKNGLFLSTKKDK-NHGIGLKSIREIVKKYN 116
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
190-415 |
3.06e-05 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 46.13 E-value: 3.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 190 QGDATQTFSVPEGSAkeFQTLADELNEYRHKINQVIKREQAFARYASHELRTPLTVMKGSsslLARSANTDFQTRQ-VNR 268
Cdd:PRK10604 176 DGHLAERIHFDEGSS--LERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYR---LEMSDNLSAAESQaLNR 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 269 iqDATQqMSTMVDALLGLVRYERnaddsPVRSITEEELNQIIFQSQAQADEKALSFDVQIDGNPRTRATNAVLTI----- 343
Cdd:PRK10604 251 --DIGQ-LEALIEELLTYARLDR-----PQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMrlmer 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 344 ILGNLIRNGIA-ATPSGSIHINMDEN--TISVRDEGEGfstIPHSD--------------------GHGLGLMIVDDLCQ 400
Cdd:PRK10604 323 VLDNLLNNALRyAHSRVRVSLLLDGNqaCLIVEDDGPG---IPPEErervfepfvrldpsrdratgGCGLGLAIVHSIAL 399
|
250
....*....|....*
gi 497392732 401 RYGWQFKIGTHPEGG 415
Cdd:PRK10604 400 AMGGSVNCDESELGG 414
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-420 |
5.34e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 41.89 E-value: 5.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 341 LTIILGNLIRNGIAAT-----PSGSIHINM----DENTISVRDEG-------------EGFSTIPHSdGHGLGLMIVDDL 398
Cdd:cd16915 1 LITIVGNLIDNALDALaatgaPNKQVEVFLrdegDDLVIEVRDTGpgiapelrdkvfeRGVSTKGQG-ERGIGLALVRQS 79
|
90 100
....*....|....*....|..
gi 497392732 399 CQRYGWQFKIGTHPEGGCEAVI 420
Cdd:cd16915 80 VERLGGSITVESEPGGGTTFSI 101
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
236-394 |
1.45e-04 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 43.97 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 236 SHELRTPLTVMKGSSSLLARSANTDFQT--RQVNRIQDATQQMSTMVDALLGLVRYernadDSPVRSITEEE------LN 307
Cdd:NF033092 380 SHELRTPLTTMRSYLEALADGAWKDPELapRFLGVTQNETERMIRLVNDLLQLSRM-----DSKDYKLNKEWvnfnefFN 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 308 QII----FQSQAQA-------DEKALsfDVQIDgnprtraTNAvLTIILGNLIRNGIAATPS-GSIHINMDEN----TIS 371
Cdd:NF033092 455 YIIdrfeMILKNKNitfkrefPKRDL--WVEID-------TDK-ITQVLDNIISNAIKYSPEgGTITFRLLEThnriIIS 524
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 497392732 372 VRDEGEGfstIPHSD--------------------GHGLGLMI 394
Cdd:NF033092 525 ISDQGLG---IPKKDldkifdrfyrvdkarsrkmgGTGLGLAI 564
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-415 |
1.67e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 40.23 E-value: 1.67e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497392732 345 LGNLIRNGIAATPSGSIHINMDENTISVRDEGEGFSTIPHSDGHGLGLMIVDDLCQRYGWQFKIGTHPEGG 415
Cdd:cd16917 9 LTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDGPAPPGGGGFGLLGMRERAELLGGTLTIGSRPGGG 79
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-415 |
1.67e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 40.91 E-value: 1.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 345 LGNLIRNGIAATPSGSI-----HINMDENTISVRDEGEG---------FSTI-----PHSD--GHGLGLMIVDDLCQRYG 403
Cdd:cd16945 9 INNLLDNAIDFSPEGGLialqlEADTEGIELLVFDEGSGipdyalnrvFERFyslprPHSGqkSTGLGLAFVQEVAQLHG 88
|
90
....*....|..
gi 497392732 404 WQFKIGTHPEGG 415
Cdd:cd16945 89 GRITLRNRPDGV 100
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
206-425 |
2.19e-04 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 43.57 E-value: 2.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 206 EFQTLADELNEYRHK-INQVIKREQaFARYASHELRTPLTVMKGSSSLLARSANTDFQTRQVNRIQDATQQmstmvdALL 284
Cdd:PRK09959 690 ETRDLIHALEVERNKaINATVAKSQ-FLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQ------SLL 762
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 285 GLV------------RYERNADDSPVRSITEEELNQiiFQSQAQADEKALSFDVQIDGNPRTRATNAVLTIILGNLIRNG 352
Cdd:PRK09959 763 GLIgeildvdkiesgNYQLQPQWVDIPTLVQNTCHS--FGAIAASKSIALSCSSTFPDHYLVKIDPQAFKQVLSNLLSNA 840
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 353 IAATPSGSIHI-----NMDEN----TISVRDEGEGFSTIPHSD---------------GHGLGLMIVDDLCQRYGWQFKI 408
Cdd:PRK09959 841 LKFTTEGAVKIttslgHIDDNhaviKMTIMDSGSGLSQEEQQQlfkrysqtsagrqqtGSGLGLMICKELIKNMQGDLSL 920
|
250
....*....|....*..
gi 497392732 409 GTHPEGGCEAVIDLASE 425
Cdd:PRK09959 921 ESHPGIGTTFTITIPVE 937
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-422 |
3.35e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 39.75 E-value: 3.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 344 ILGNLIRNGIAAT---PSGSIHINM----DENTISVRDEGEG-------------FSTIPHSDGHGLGLMIVDDLCQRYG 403
Cdd:cd16976 4 VLMNLLQNALDAMgkvENPRIRIAArrlgGRLVLVVRDNGPGiaeehlsrvfdpfFTTKPVGKGTGLGLSISYGIVEEHG 83
|
90
....*....|....*....
gi 497392732 404 WQFKIGTHPEGGCEAVIDL 422
Cdd:cd16976 84 GRLSVANEEGAGARFTFDL 102
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
126-394 |
5.53e-04 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 42.32 E-value: 5.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 126 VEHPV-------ILVSLIDEIEITSeefiLVVAMVLSIVAVLVFLFGSLLLRLSQRLIEPVN-ALKTQLDHHQGDATQTF 197
Cdd:NF040691 160 VTLPVagnyelyLLFPLEDEQSTLA----LVRGTLLLGGLALVVLLGLIAWLVTRQVVAPVRsAARTAERFAAGDLSERM 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 198 SVpEGS------AKEFQTLADELneyRHKINQV---IKREQAFARYASHELRTPLTVMKGSSSLLARSANtDF---QTRQ 265
Cdd:NF040691 236 PV-KGEddlarlARSFNQMADSL---QRQIRQLeelSRLQQRFVSDVSHELRTPLTTIRMAADVIHDSRD-DFdpaTARS 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 266 VNRIQDATQQMSTMVDALLGLVRY-----ERNADDSPVRSITE---EELNQIIFQ--SQAQADEKALSFDVQIDgnPR-- 333
Cdd:NF040691 311 AELLHTELDRFESLLSDLLEISRFdagaaELDVEPVDLRPLVRrvvDALRQLAERagVELRVDAPGTPVVAEVD--PRrv 388
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 334 TRatnavltiILGNLIRNGIAATPSGSIHINMDEN----TISVRDEGEGF-----------------STIPHSDGHGLGL 392
Cdd:NF040691 389 ER--------VLRNLVVNAIEHGEGKPVVVTVAQDdtavAVTVRDHGVGLkpgevalvfdrfwradpARARTTGGTGLGL 460
|
..
gi 497392732 393 MI 394
Cdd:NF040691 461 AI 462
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
206-378 |
1.16e-03 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 40.91 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 206 EFQTLADELNEYRHKINQVIKREQAFARYASHELRTPLTvmkgssSLLARSANTDFQTRQVNRIQDAT-------QQMST 278
Cdd:PRK09835 240 ELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPIT------NLITQTEIALSQSRSQKELEDVLysnleelTRMAK 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 279 MVDALLGLVRYERNaddspvRSITE-------EELNQI--IFQSQAQADEKALSFD---VQIDGNPrtratnAVLTIILG 346
Cdd:PRK09835 314 MVSDMLFLAQADNN------QLIPEkkmldlaDEVGKVfdFFEAWAEERGVELRFVgdpCQVAGDP------LMLRRAIS 381
|
170 180 190
....*....|....*....|....*....|....*
gi 497392732 347 NLIRNGIAATPSG---SIHINMDENTISVRDEGEG 378
Cdd:PRK09835 382 NLLSNALRYTPAGeaiTVRCQEVDHQVQLVVENPG 416
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
345-405 |
1.58e-03 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 37.63 E-value: 1.58e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497392732 345 LGNLIRNGIAATPSGSIHINMDEN----TISVRDEGEGFSTIPHSD------GHGLGLMIVDDLCQRYGWQ 405
Cdd:cd16936 9 VTNAVRHAYRHDGPGPVRLELDLDpdrlRVEVTDSGPGFDPLRPADpdaglrEGGRGLALIRALMDEVGYR 79
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
347-405 |
2.15e-03 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 37.97 E-value: 2.15e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497392732 347 NLIRNGIAATPSGSIHI--NMDEN--TISVRDEGEGFST------IPHSDGHGLGLMIVDDLCQRYGWQ 405
Cdd:COG2172 45 NAVRHAYGGDPDGPVEVelELDPDglEIEVRDEGPGFDPedlpdpYSTLAEGGRGLFLIRRLMDEVEYE 113
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
237-428 |
2.95e-03 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 39.95 E-value: 2.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 237 HELRTPLTVMKGSSSLLARSANTDFQTRQVNRIQDATQQMSTMVDALLGLVRyERNADDSPVrsiteeELNQII------ 310
Cdd:PRK11360 399 HEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSR-PRESQWQPV------SLNALVeevlql 471
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 311 FQSQAQADEkaLSFDVQIDGN-PRTRATNAVLTIILGNLIRNGIAATP-SGSIHINM-----DENTISVRDEGEG----- 378
Cdd:PRK11360 472 FQTAGVQAR--VDFETELDNElPPIWADPELLKQVLLNILINAVQAISaRGKIRIRTwqysdGQVAVSIEDNGCGidpel 549
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 497392732 379 --------FSTIPHsdGHGLGLMIVDDLCQRYGWQFKIGTHPEGGCEAVIDLASEHQE 428
Cdd:PRK11360 550 lkkifdpfFTTKAK--GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQG 605
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
176-288 |
3.46e-03 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 39.63 E-value: 3.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 176 IEPVNaLKTQLDHHQGDATQTFSVPEGSAKEFQTLADelNEYRHKINqvIKREQ---AFARYASHELRTPLTVMKGSSSL 252
Cdd:PRK10490 614 VEPGN-LRQLMIPEQQRLLETFTLLIANALERLTLTA--SEEQARLA--SEREQlrnALLAALSHDLRTPLTVLFGQAEI 688
|
90 100 110
....*....|....*....|....*....|....*...
gi 497392732 253 LAR--SANTDFQTRQVNRIQDATQQMSTMVDALLGLVR 288
Cdd:PRK10490 689 LTLdlASEGSPHARQASEIRQQVLNTTRLVNNLLDMAR 726
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
206-415 |
5.65e-03 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 39.12 E-value: 5.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 206 EFQTLADELNEYRHKINQVIKREQAFARYASHELRTPLTVMKGSSSLLARSANTDFQTRQVNRIQDATQQMSTMVDALLG 285
Cdd:PRK11466 422 ELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLTILNDILD 501
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 286 LVRYERNA-----DDSPV--RSITEEELNqiIFQSQAQADEKALSFDVQ------IDGNPRTratnavLTIILGNLIRNG 352
Cdd:PRK11466 502 YSAIEAGGknvsvSDEPFepRPLLESTLQ--LMSGRVKGRPIRLATDIAddlptaLMGDPRR------IRQVITNLLSNA 573
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 353 IAATPSGSIHIN--MDENT--ISVRDEGEGFSTIPHSD-------------GHGLGLMIVDDLCQRYGWQFKIGTHPEGG 415
Cdd:PRK11466 574 LRFTDEGSIVLRsrTDGEQwlVEVEDSGCGIDPAKLAEifqpfvqvsgkrgGTGLGLTISSRLAQAMGGELSATSTPEVG 653
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-422 |
5.97e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 37.01 E-value: 5.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 325 DVQIDGNPRTrATNAVLTIILGNLIRNGIAATPSGSIHINM----DENTISVRDEGEGFSTI--PHSDGHgLGLMIVDDL 398
Cdd:cd16951 29 TGPVSSEVAT-AIGLVVNELLQNALKHAFSDREGGTITIRSvvdgDYLRITVIDDGVGLPQDedWPNKGS-LGLQIVRSL 106
|
90 100
....*....|....*....|....
gi 497392732 399 CQRYGWQFKIGTHPEGGCEAVIDL 422
Cdd:cd16951 107 VEGELKAFLEVQSAENGTRVNIDI 130
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
367-425 |
6.60e-03 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 38.68 E-value: 6.60e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 367 ENTISVRDEGEGFSTIPHSDGH-GLGLMivDDLCQRYGWQFKIGTHPEGGCEAVIDLASE 425
Cdd:PRK10935 503 EHTVSIRDDGIGIGELKEPEGHyGLNIM--QERAERLGGTLTISQPPGGGTTVSLTFPSQ 560
|
|
| ZnMc_serralysin_like |
cd04277 |
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ... |
289-392 |
9.06e-03 |
|
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides.
Pssm-ID: 239804 [Multi-domain] Cd Length: 186 Bit Score: 37.01 E-value: 9.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497392732 289 YERNADDSPVRSITEEELNQIIFQSQAQADEKALSFdVQIDGNprtraTNAVLTIILGNLIRNGIAAT-----------P 357
Cdd:cd04277 19 YGREEDTTNTAALSAAQQAAARDALEAWEDVADIDF-VEVSDN-----SGADIRFGNSSDPDGNTAGYayypgsgsgtaY 92
|
90 100 110
....*....|....*....|....*....|....*
gi 497392732 358 SGSIHINMDENTISVRDEGEGFSTIPHSDGHGLGL 392
Cdd:cd04277 93 GGDIWFNSSYDTNSDSPGSYGYQTIIHEIGHALGL 127
|
|
| |
