NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|497339922|ref|WP_009654135|]
View 

MULTISPECIES: MFS transporter [Klebsiella]

Protein Classification

MFS transporter( domain architecture ID 13022956)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0055085|GO:0022857|GO:0016020
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 16-460 5.60e-55

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 187.77  E-value: 5.60e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  16 LLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGM 95
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  96 ANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAFFIN 175
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLEL----FGWRWIFLIN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 176 VPICLLVLAFSPRYvpetrreahsridwqgtfslalilccllfpmalgpelhwpwtlqlmlaavlpllvwmrasalskqq 255
Cdd:cd17321  157 VPIGLVALLLARTF------------------------------------------------------------------ 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 256 rgeqpllpprllkltsiRFGMAIALLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFISALYAPKLIARYSM 335
Cdd:cd17321  171 -----------------SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGP 233

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 336 GRILLTGLSVQIVGLLLLSatfyRLGIHTTTLALVPSTALIGYGQALIVNSFYRIGMRDISASDAGAGSAILSTLQQATL 415
Cdd:cd17321  234 RLVLVAGLLLTAVGLLLLA----LLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGG 309

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 497339922 416 GLGPAILGSLFLTLAQRSGGDYPRALIDFLAVEV------VMMLVLGAIAL 460
Cdd:cd17321  310 ALGVALLGALLTAGLSANLGDSGVAALLSAAAAAfaagfhLAFLVAAALAL 360
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 16-460 5.60e-55

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 187.77  E-value: 5.60e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  16 LLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGM 95
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  96 ANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAFFIN 175
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLEL----FGWRWIFLIN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 176 VPICLLVLAFSPRYvpetrreahsridwqgtfslalilccllfpmalgpelhwpwtlqlmlaavlpllvwmrasalskqq 255
Cdd:cd17321  157 VPIGLVALLLARTF------------------------------------------------------------------ 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 256 rgeqpllpprllkltsiRFGMAIALLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFISALYAPKLIARYSM 335
Cdd:cd17321  171 -----------------SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGP 233

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 336 GRILLTGLSVQIVGLLLLSatfyRLGIHTTTLALVPSTALIGYGQALIVNSFYRIGMRDISASDAGAGSAILSTLQQATL 415
Cdd:cd17321  234 RLVLVAGLLLTAVGLLLLA----LLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGG 309

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 497339922 416 GLGPAILGSLFLTLAQRSGGDYPRALIDFLAVEV------VMMLVLGAIAL 460
Cdd:cd17321  310 ALGVALLGALLTAGLSANLGDSGVAALLSAAAAAfaagfhLAFLVAAALAL 360
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 13-421 4.55e-33

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 130.96  E-value: 4.55e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   13 LFLLLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLL 92
Cdd:TIGR00711   4 TIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   93 CGMANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAF 172
Cdd:TIGR00711  84 CGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIEN----YHWRWIF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  173 FINVPICLLVLAFSPRYVPETRREAHSRIDWQGTFSLALILCCLLFPMALGPELHWPWTLQLMLAAVLPLLVWmrASALS 252
Cdd:TIGR00711 160 LINVPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAI--IAFVV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  253 KQQRGEQPLLPPRLLKLTSIRFGMAIALLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFISALYAPKLIAR 332
Cdd:TIGR00711 238 WELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDK 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  333 YSMGRILLTGLSVQIVGLLLLSATFyrlGIHTTTLALVPSTALIGYGQALIVNSFYRIGMRDISASDAGAGSAILSTLQQ 412
Cdd:TIGR00711 318 IDPRKLVTIGLILYAVGFYWRAFTF---TPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQ 394


                  ....*....
gi 497339922  413 ATLGLGPAI 421
Cdd:TIGR00711 395 LGGSIGTAL 403
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
3-413 9.85e-31

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 121.62  E-value: 9.85e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   3 SSAVSPGRAGLFLLLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWG 82
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  83 VAIFGVASLLCGMANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAd 162
Cdd:COG2814   82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 163 iagLGWRNAFFINVPICLLVLAFSPRYVPETRREAHSRidwqgtfslalilccllfpmalgpelhwpwtlqlmLAAVLPL 242
Cdd:COG2814  161 ---FGWRWVFLVNAVLALLALLLLLRLLPESRPAARAR-----------------------------------LRGSLRE 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 243 LVWMRAsalskqqrgeqpllpprllkltsIRFGMAIALLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFIS 322
Cdd:COG2814  203 LLRRPR-----------------------LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLG 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 323 ALYAPKLIARYSMGRILLTGLSVQIVGLLLLSATfyrlgihTTTLALVPSTALIGYGQALIVNSFYRIGMRDISASDAGA 402
Cdd:COG2814  260 ALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA-------GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGR 332

                        410
                 ....*....|.
gi 497339922 403 GSAILSTLQQA 413
Cdd:COG2814  333 ASGLYNSAFFL 343
PRK14995 PRK14995
SmvA family efflux MFS transporter;
25-425 2.76e-22

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 99.42  E-value: 2.76e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  25 IDTSIANVALDSITQSLNASATQLELIVALYGVAFA-VCLAMGSkLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLL 103
Cdd:PRK14995  20 IDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAgMVLPMGA-LGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 104 AARAVQGAGAALIVPQILATL-HITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAFFINVPICLLV 182
Cdd:PRK14995  99 ATRALLAIGAAMIVPATLAGIrATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEH----FYWGSVFLINVPIVLVV 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 183 LAFSPRYVPetRREAHSRIDWQGTFSLALILCCLLFPMALGPELH---WPWTLQLMLAAVLPLLVWMrasaLSKQQRGEQ 259
Cdd:PRK14995 175 MGLTARYVP--RQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKgflSLWVTSLTLLTGALLLGLF----IRTQLAASR 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 260 PLLPPRLLKLTSIRFGMAIALLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFISALYAPKLIARYSMGRIL 339
Cdd:PRK14995 249 PMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVA 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 340 LTGLSVQIVGLLLLSATFYRlgihTTTLALVPSTALIGYGQALIVNSFYRIGMRDISASDAGAGSAILSTLQQATLGLGP 419
Cdd:PRK14995 329 TGGMALSALSFYGLAMTDFS----TQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGI 404


                 ....*.
gi 497339922 420 AILGSL 425
Cdd:PRK14995 405 AIFGLL 410
MFS_1 pfam07690
Major Facilitator Superfamily;
16-419 1.30e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 74.76  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   16 LLTGQMLPLIDTSIANVAL-DSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCG 94
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   95 MANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAFFI 174
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL----FGWRAAFLI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  175 NVPICLLVLAFSPRYVPETRREAHSridwqgtfslalilccllfpmalgpelhwpwtlqlmlaavlpllvwmrasalSKQ 254
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPK----------------------------------------------------PAE 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  255 QRGEQPLLPPRLLKLTSIRFGMAIALLFFSAWSGFMFcMALTMQAGLGMAPWQSGNSFIALGVAYFISALYAPKLIARYS 334
Cdd:pfam07690 185 EARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT-YLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLG 263

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  335 MGRILLTGLSVQIVGLLLLSATFYRLGIHTTTLALVpstaLIGYGQALIVNSFYRIGMRDISASDAGAGSAILSTLQQAT 414
Cdd:pfam07690 264 RRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALL----LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339


                  ....*
gi 497339922  415 LGLGP 419
Cdd:pfam07690 340 GALGP 344
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 16-460 5.60e-55

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 187.77  E-value: 5.60e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  16 LLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGM 95
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  96 ANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAFFIN 175
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLEL----FGWRWIFLIN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 176 VPICLLVLAFSPRYvpetrreahsridwqgtfslalilccllfpmalgpelhwpwtlqlmlaavlpllvwmrasalskqq 255
Cdd:cd17321  157 VPIGLVALLLARTF------------------------------------------------------------------ 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 256 rgeqpllpprllkltsiRFGMAIALLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFISALYAPKLIARYSM 335
Cdd:cd17321  171 -----------------SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGP 233

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 336 GRILLTGLSVQIVGLLLLSatfyRLGIHTTTLALVPSTALIGYGQALIVNSFYRIGMRDISASDAGAGSAILSTLQQATL 415
Cdd:cd17321  234 RLVLVAGLLLTAVGLLLLA----LLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGG 309

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 497339922 416 GLGPAILGSLFLTLAQRSGGDYPRALIDFLAVEV------VMMLVLGAIAL 460
Cdd:cd17321  310 ALGVALLGALLTAGLSANLGDSGVAALLSAAAAAfaagfhLAFLVAAALAL 360
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 13-421 4.55e-33

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 130.96  E-value: 4.55e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   13 LFLLLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLL 92
Cdd:TIGR00711   4 TIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   93 CGMANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAF 172
Cdd:TIGR00711  84 CGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIEN----YHWRWIF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  173 FINVPICLLVLAFSPRYVPETRREAHSRIDWQGTFSLALILCCLLFPMALGPELHWPWTLQLMLAAVLPLLVWmrASALS 252
Cdd:TIGR00711 160 LINVPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAI--IAFVV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  253 KQQRGEQPLLPPRLLKLTSIRFGMAIALLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFISALYAPKLIAR 332
Cdd:TIGR00711 238 WELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDK 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  333 YSMGRILLTGLSVQIVGLLLLSATFyrlGIHTTTLALVPSTALIGYGQALIVNSFYRIGMRDISASDAGAGSAILSTLQQ 412
Cdd:TIGR00711 318 IDPRKLVTIGLILYAVGFYWRAFTF---TPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQ 394


                  ....*....
gi 497339922  413 ATLGLGPAI 421
Cdd:TIGR00711 395 LGGSIGTAL 403
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 16-452 1.06e-31

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 125.00  E-value: 1.06e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  16 LLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGM 95
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  96 ANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAFFIN 175
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDN----LSWRWIFYIN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 176 VPICLLVLAFSPryvpetrreahsridwqgtfslalilccllfpmalgpelhwpwtlqlmlaaVLPLLVWMRAsalskqq 255
Cdd:cd17503  157 LPIGILALLLAP---------------------------------------------------LLDLRLFKDR------- 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 256 rgeqpllpprllkltSIRFGMAIALLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFISALYAPKLIARYSM 335
Cdd:cd17503  179 ---------------NFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGP 243

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 336 GRILLTGLSVQIVGLLLLSatfyRLGIHTTTLALVPSTALIGYGQALIVNSFYRIGMRDISASDAGAGSAILSTLQQATL 415
Cdd:cd17503  244 RLLLLAGLLLLALGTLLLA----FLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGG 319

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 497339922 416 GLGPAILGSLFLTLAQRSGGDYPRALIDFLAVEVVMM 452
Cdd:cd17503  320 SIGTALLATLLTNRTQFHHSRLSELLAQQVQKQALII 356
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
3-413 9.85e-31

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 121.62  E-value: 9.85e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   3 SSAVSPGRAGLFLLLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWG 82
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  83 VAIFGVASLLCGMANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAd 162
Cdd:COG2814   82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 163 iagLGWRNAFFINVPICLLVLAFSPRYVPETRREAHSRidwqgtfslalilccllfpmalgpelhwpwtlqlmLAAVLPL 242
Cdd:COG2814  161 ---FGWRWVFLVNAVLALLALLLLLRLLPESRPAARAR-----------------------------------LRGSLRE 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 243 LVWMRAsalskqqrgeqpllpprllkltsIRFGMAIALLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFIS 322
Cdd:COG2814  203 LLRRPR-----------------------LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLG 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 323 ALYAPKLIARYSMGRILLTGLSVQIVGLLLLSATfyrlgihTTTLALVPSTALIGYGQALIVNSFYRIGMRDISASDAGA 402
Cdd:COG2814  260 ALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA-------GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGR 332

                        410
                 ....*....|.
gi 497339922 403 GSAILSTLQQA 413
Cdd:COG2814  333 ASGLYNSAFFL 343
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-296 3.85e-26

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 107.59  E-value: 3.85e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   1 MNSSAVSPGRAGLFLLLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFM 80
Cdd:COG0477    4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  81 WGVAIFGVASLLCGMANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVS 160
Cdd:COG0477   84 IGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 161 AdiagLGWRNAFFINVPICLLVLAFSPRYVPETRREAHSRIDWQGTFSLALILCCLLFPMALGPELHWPWTLQLMLAAVL 240
Cdd:COG0477  164 A----LGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAAL 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 497339922 241 PLLVWMRASALSKQQRGEQPLLPPRLLKLTSIRFGMAIALLFFSAWSGFMFCMALT 296
Cdd:COG0477  240 LLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 13-430 8.18e-26

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 108.43  E-value: 8.18e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  13 LFLLLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLL 92
Cdd:cd17320    1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  93 CGMANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAF 172
Cdd:cd17320   81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLF----FGWRAIF 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 173 FINVPICLLVLAFSPRYVPETRREAHSRIDWQGTF-SLALILCCLLFpmalgpelhwpwtlqlmlaavlpllvwmrasal 251
Cdd:cd17320  157 VFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLrAYKRVLKNRRF--------------------------------- 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 252 skqqrgeqpllpprllkltsIRFGMAIAlLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFISALYAPKLIA 331
Cdd:cd17320  204 --------------------LGYALALG-LSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVR 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 332 RYSMGRILLTGLSVQIVGLLLLSATFyrLGIHTTTLALVPSTALIGYGQALIVNSFYRIGMRDISaSDAGAGSAILSTLQ 411
Cdd:cd17320  263 RFGPRRLLRLGLLLLLAAALVLLLAA--LLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTASALLGFLQ 339

                        410
                 ....*....|....*....
gi 497339922 412 QATLGLGPAILGSLFLTLA 430
Cdd:cd17320  340 FLIGALAGALVGLLPNGTA 358
PRK14995 PRK14995
SmvA family efflux MFS transporter;
25-425 2.76e-22

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 99.42  E-value: 2.76e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  25 IDTSIANVALDSITQSLNASATQLELIVALYGVAFA-VCLAMGSkLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLL 103
Cdd:PRK14995  20 IDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAgMVLPMGA-LGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 104 AARAVQGAGAALIVPQILATL-HITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAFFINVPICLLV 182
Cdd:PRK14995  99 ATRALLAIGAAMIVPATLAGIrATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEH----FYWGSVFLINVPIVLVV 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 183 LAFSPRYVPetRREAHSRIDWQGTFSLALILCCLLFPMALGPELH---WPWTLQLMLAAVLPLLVWMrasaLSKQQRGEQ 259
Cdd:PRK14995 175 MGLTARYVP--RQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKgflSLWVTSLTLLTGALLLGLF----IRTQLAASR 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 260 PLLPPRLLKLTSIRFGMAIALLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFISALYAPKLIARYSMGRIL 339
Cdd:PRK14995 249 PMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVA 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 340 LTGLSVQIVGLLLLSATFYRlgihTTTLALVPSTALIGYGQALIVNSFYRIGMRDISASDAGAGSAILSTLQQATLGLGP 419
Cdd:PRK14995 329 TGGMALSALSFYGLAMTDFS----TQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGI 404


                 ....*.
gi 497339922 420 AILGSL 425
Cdd:PRK14995 405 AIFGLL 410
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 33-200 3.63e-17

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 83.00  E-value: 3.63e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  33 ALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAG 112
Cdd:cd17474   21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 113 AALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLvsadiAGLGWRNAFFINVPICLLVLAFSPRYVPE 192
Cdd:cd17474  101 AAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-----AAISWRYPFFLLAALIPVAFLAILFLLPE 175


                 ....*...
gi 497339922 193 TRREAHSR 200
Cdd:cd17474  176 PKEKAKSS 183
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 16-187 5.09e-17

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 81.84  E-value: 5.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  16 LLTGQMLPLIDTSIANVALDSITQSLNaSATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGM 95
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  96 ANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSadiaGLGWRNAFFIN 175
Cdd:cd17502   80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTD----HLSWRWCFYIN 155

                        170
                 ....*....|..
gi 497339922 176 VPICLLVLAFSP 187
Cdd:cd17502  156 LPIGGLALALLR 167
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 33-425 6.89e-17

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 81.86  E-value: 6.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  33 ALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAG 112
Cdd:cd17504   18 ALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 113 AAlIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAFFINVPICLLVLAFSPRYVPE 192
Cdd:cd17504   98 GA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQH----LGWRWIFWTAAPVAVLLAALVPLIDLR 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 193 TRREAhsridwqgtfSLALILCCLLFpmalgpelhwpwtlqlmlaavlpllvwmrasalskqqrgeqpllpprllkltsi 272
Cdd:cd17504  173 LLRRR----------NVLLANITALL------------------------------------------------------ 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 273 rfgmaIALLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFISALYAPKLIARYSMGRILLTGLSVQIVGLLL 352
Cdd:cd17504  189 -----AGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLL 263

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497339922 353 LSAtfyrlgIHTTTLALVPSTALIGYGQALIVNSFYRIGMRDISASDAGAGSAILSTLQQATLGLGPAILGSL 425
Cdd:cd17504  264 LAL------LHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
13-186 1.72e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 80.68  E-value: 1.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  13 LFLLLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLL 92
Cdd:COG2271   12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  93 CGMANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAF 172
Cdd:COG2271   92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA----FGWRAAF 167

                        170
                 ....*....|....
gi 497339922 173 FINVPICLLVLAFS 186
Cdd:COG2271  168 LILGLPGLLLALLR 181
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 39-426 4.03e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 76.85  E-value: 4.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  39 QSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGAALIVP 118
Cdd:cd17325   24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 119 QILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAFFINVPICLLVLAFSPRYVPETRREAH 198
Cdd:cd17325  104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA----LGYRAPFLVCAALALLALVLALLLLPEPRPPPN 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 199 SRIDWQGTFSLALILccllfpmalgpelhwpwtlqlmlaavlpllvwmrasalskqqrgeqpllpprLLKLTSIRFGMAI 278
Cdd:cd17325  180 KRAVSAARLRSGLRL----------------------------------------------------LLRDRRLLALFLA 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 279 ALLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFISALYAPKLIARYsmGRILLTglsvqIVGLLLLSATFY 358
Cdd:cd17325  208 IFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI--GRKPLI-----LIGLLLSAVALL 280

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497339922 359 RLGIHTTTLALVPSTALIGYGQALIVNSFYRIGMRDISASDAGAGSAILSTLQQATLGLGPAILGSLF 426
Cdd:cd17325  281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLY 348
MFS_1 pfam07690
Major Facilitator Superfamily;
16-419 1.30e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 74.76  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   16 LLTGQMLPLIDTSIANVAL-DSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCG 94
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   95 MANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAFFI 174
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL----FGWRAAFLI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  175 NVPICLLVLAFSPRYVPETRREAHSridwqgtfslalilccllfpmalgpelhwpwtlqlmlaavlpllvwmrasalSKQ 254
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPK----------------------------------------------------PAE 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  255 QRGEQPLLPPRLLKLTSIRFGMAIALLFFSAWSGFMFcMALTMQAGLGMAPWQSGNSFIALGVAYFISALYAPKLIARYS 334
Cdd:pfam07690 185 EARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT-YLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLG 263

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  335 MGRILLTGLSVQIVGLLLLSATFYRLGIHTTTLALVpstaLIGYGQALIVNSFYRIGMRDISASDAGAGSAILSTLQQAT 414
Cdd:pfam07690 264 RRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALL----LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339


                  ....*
gi 497339922  415 LGLGP 419
Cdd:pfam07690 340 GALGP 344
PRK10504 PRK10504
putative transporter; Provisional
 10-464 2.38e-14

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 75.15  E-value: 2.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  10 RAGLFLLLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVA 89
Cdd:PRK10504   9 RWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  90 SLLCGMANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWR 169
Cdd:PRK10504  89 SLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEY----ASWH 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 170 NAFFINVPI----CLLVLAFSPRYVPETRreahsRIDWQGTFSLALILCCLlfPMAL----GPELHWPWTLQLMLAAVLP 241
Cdd:PRK10504 165 WIFLINIPVgiigAIATLMLMPNYTMQTR-----RFDLSGFLLLAVGMATL--TLALdgskGLGLSPLAIAGLVAVGVVA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 242 LLV-WMRAsalskqQRGEQPLLPPRLLKLTSIRFGMAIALLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYF 320
Cdd:PRK10504 238 LLLyLLHA------RNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSM 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 321 ISALYAPKLIARYSMGRILLtglsVQIVGLLLLSATFYRLGIHTTTLALVPSTALIGYGQALIVNSFYRIGMRDISASDA 400
Cdd:PRK10504 312 GMKRIVVQVVNRFGYRRVLV----ATTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLA 387

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497339922 401 GAGSAILSTLQQATLGLGPAILGSLFLTLAQRS-GGDYPRALIDFLAVEVVMMLVLGAIALWLRR 464
Cdd:PRK10504 388 SSGNSLLSMIMQLSMSIGVTIAGLLLGLFGQQHvSVDSGATHTVFMYTYLCMALIIALPALIFAR 452
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 14-182 8.85e-14

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 72.68  E-value: 8.85e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  14 FLLLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLC 93
Cdd:cd17476    1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  94 GMANSITTLLAARAVQGAGAALIVPQILATLHITLK-GTAHARAISLYGGIGGIAFIVGQMGGGWLvsADIAGLGWrnAF 172
Cdd:cd17476   81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPpGPRKNIVFSLFGATAPLGFALGGVFGGLF--AQLAWWPW--IF 156

                        170
                 ....*....|
gi 497339922 173 FINVPICLLV 182
Cdd:cd17476  157 WFLAILAAIV 166
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 34-426 1.01e-13

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 72.58  E-value: 1.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  34 LDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGA 113
Cdd:cd17324   22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 114 ALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAFFINVPICLLVLAFSPRYVPET 193
Cdd:cd17324  102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQL----LGWRAAFLAIAVLALLAALLLWRLLPSL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 194 RREAHSRIDWQGTFSLALilccllfpmalgpelhwpwtlqlmlaavlpllvwmrasalskqqrgeqpllpprllKLTSIR 273
Cdd:cd17324  178 PPKKPGSLGLLSSLLLLL--------------------------------------------------------RNPRLR 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 274 FGMAIALLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFISALYAPKLIARYSMGRILLTGLSVQIVGLLLl 353
Cdd:cd17324  202 LAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLL- 280

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497339922 354 satfyrLGIHTTTLALVPSTALIGYGQALIVNSFYRIGMRdISASDAGAGSAILSTLQQATLGLGPAILGSLF 426
Cdd:cd17324  281 ------TLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR-LAPEARGLASSLYLAAYNLGGALGAALGGLVL 346
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 8-203 5.90e-12

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 67.02  E-value: 5.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922    8 PGRAGLFLLLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFG 87
Cdd:TIGR00710   2 SAKAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   88 VASLLCGMANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLvsadIAGLG 167
Cdd:TIGR00710  82 LSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYI----LVWLS 157

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 497339922  168 WRNAFFINVPICLLVLAFSPRYVPETR---REAHSRIDW 203
Cdd:TIGR00710 158 WHAIFAFLSLAGILLSALIFFILPETLpyeARIQISTYF 196
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 13-200 6.07e-12

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 66.83  E-value: 6.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  13 LFLLLTGQMLPLIDTSIANVALDSITQS-LNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASL 91
Cdd:cd17473    1 LITLLLASTLTVMAGAAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  92 LCGMANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLvsadiAGLGWRNA 171
Cdd:cd17473   81 AGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL-----AEIGWRAP 155

                        170       180
                 ....*....|....*....|....*....
gi 497339922 172 FFINVpICLLVLAFSPRYVPETRREAHSR 200
Cdd:cd17473  156 FLVYL-LALPVLILVLLFLPEPARKSKSA 183
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 25-192 1.97e-11

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 65.46  E-value: 1.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   25 IDTSIANVALDSITQSLNASATQLELIV--ALYGVAFAVCLamGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTL 102
Cdd:TIGR00895  31 YDLAAMGFAAPAISAEWGLDPVQLGFLFsaGLIGMAFGALF--FGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  103 LAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYggigGIAFIVGQMGGGWLVSADIAGLGWRNAFFINVPICLLV 182
Cdd:TIGR00895 109 LILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLM----FCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLL 184

                         170
                  ....*....|
gi 497339922  183 LAFSPRYVPE 192
Cdd:TIGR00895 185 LLLLMRFLPE 194
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
37-193 2.87e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 61.82  E-value: 2.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  37 ITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGAALI 116
Cdd:COG2223   31 LAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGS 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 497339922 117 VPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLvsadIAGLGWRNAFFINVPICLLVLAFSPRYVPET 193
Cdd:COG2223  111 FAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL----IAAFGWRNAFLILGILLLVVAVLAWLFLRDP 183
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 16-426 3.04e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 61.67  E-value: 3.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  16 LLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGM 95
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  96 ANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSadIAGLGWRNAFFIN 175
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS--SLGFGWRAVFLIA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 176 VPICLLVLAFSPRYVPETRREAhsridwqgtfslalilccllfPMALGPELHWPWTLQLMLAAVLPLLVWMrasalskqq 255
Cdd:cd06174  159 AALALLAAILLLLVVPDPPESA---------------------RAKNEEASSKSVLKLLKRVLKNPGLWLL--------- 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 256 rgeqpllpprllkltsirfgMAIALLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFISALYAPKLIARYSM 335
Cdd:cd06174  209 --------------------LLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 336 GRILLtglsvqIVGLLLLSATFYRLGIHTTTLALVPSTALIGYGQALIVNSFYRIGMRDISASDAGAGSAILSTLQQATL 415
Cdd:cd06174  269 RKPLL------LIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGG 342

                        410
                 ....*....|.
gi 497339922 416 GLGPAILGSLF 426
Cdd:cd06174  343 AIGPLLAGFLL 353
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
32-143 4.32e-10

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 61.19  E-value: 4.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  32 VALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGA 111
Cdd:PRK10473  24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103

                         90       100       110
                 ....*....|....*....|....*....|..
gi 497339922 112 GAALIVPQILATLHITLKGTAHARAISLYGGI 143
Cdd:PRK10473 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGI 135
2_A_01_02 TIGR00880
Multidrug resistance protein;
50-193 7.46e-10

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 57.27  E-value: 7.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   50 LIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGAALIVPQILATLHITLK 129
Cdd:TIGR00880   2 LLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497339922  130 GTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAFFINVPICLLVLAFSPRYVPET 193
Cdd:TIGR00880  82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQF----LGWRAPFLFLAILALAAFILLAFLLPET 141
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
27-467 1.27e-09

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 59.87  E-value: 1.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  27 TSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAAR 106
Cdd:COG0738   24 TALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLAL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 107 AVQGAGAALIvpQILATLHITLKGTAHARAI-SLYGGIGGIAFIVGQMGGGWLVSADIaGLGWRNAFFIN-VPICLLVLA 184
Cdd:COG0738  104 FLLGLGLGLL--DVAANPYVAALGPETAASRlNLLHAFFSLGALLGPLLGGLLILLGL-SLSWHLPYLILaVLLLLLALL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 185 FSPRYVPETRREAHSRIDWQGTFSLALilccllfpmalgpelhwpwtlqlmlaavlpllvwmrasalskqqrgeqpllpp 264
Cdd:COG0738  181 FLRSKLPEIEEEEEEAAGSAASLKSLL----------------------------------------------------- 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 265 rllKLTSIRFGMAIALLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFISALYAPKLIARYSMGRILLTGLS 344
Cdd:COG0738  208 ---KNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSAL 284

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 345 VQIVGLLLLSATfyrlgihTTTLALVPSTALIGYGQALIVNSFYRIGMRDISASDAGAGSAILSTlqqATLG--LGPAIL 422
Cdd:COG0738  285 LAAVGLLLALLA-------PGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIM---GIVGgaIGPPLI 354

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 497339922 423 GSlfltLAQRSGGDYpralidFLAVEVVMMLVLGAIALWLRRHLN 467
Cdd:COG0738  355 GF----LADAFGLRA------AFLVPLVCYLLILLLALALKRKRR 389
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 13-188 7.60e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 57.23  E-value: 7.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  13 LFLLLTGQMLPLIDTSIANVALDSITQSLNaSATQLELIVALYGVAFAVCL---AMGSKLGDNYGRRRLFMWGVAIFGVA 89
Cdd:cd17316    1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFS-LGLSLLQTGLLFAAGFLGRPigaLLFGYLGDRIGRKKALILTLLLFGLA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  90 SLLCGMANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSADIAGLGWR 169
Cdd:cd17316   80 TLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWR 159

                        170
                 ....*....|....*....
gi 497339922 170 NAFFINVPICLLVLAFSPR 188
Cdd:cd17316  160 ILFLIGALPALLALLLRRR 178
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 13-174 1.58e-08

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 56.42  E-value: 1.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  13 LFLLLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLL 92
Cdd:cd17319    5 IPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTAL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  93 CGMANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAF 172
Cdd:cd17319   85 TGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLL----FGWRWAF 160


                 ..
gi 497339922 173 FI 174
Cdd:cd17319  161 II 162
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 39-423 1.97e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 56.06  E-value: 1.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  39 QSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGAAlIVP 118
Cdd:cd17489   24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWG-AFT 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 119 QILATLHITLKGTAH-ARAISLYGGIGGIAFIVGQMGGGWLVSadiaglgwrnaffinvpicllvlafspryvpetrrea 197
Cdd:cd17489  103 TAAATLVADIIPPSRrGEGIGYYGLATTLAMALGPALGLFLYQ------------------------------------- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 198 HSRIDWQGTFSLALILccllfpmalgpelhwpwtlqlmLAAVLPLLVWMRASALSKQQRGEqpLLPPRLLKLTSIRFGMA 277
Cdd:cd17489  146 HLGFAVLFIVAAVLAL----------------------LALLLVFLVKDPPPVAAEEAEAG--TRAFRRLVEKKVLPPAL 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 278 IALLFFSAWSGFMFCMALTMQAGLgmaPWQSGNSFIALGVAYFISALYAPKLIARYSMGRILLTGLSVQIVGLLLLSATf 357
Cdd:cd17489  202 ILFLASIAYGAISTFLPLYAAERG---ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA- 277

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497339922 358 yrlgihTTTLALVPSTALIGYGQALIVNSFYRIGMRDISASDAGAGSAILSTLQQATLGLGPAILG 423
Cdd:cd17489  278 ------GSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLG 337
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 42-200 2.99e-08

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 55.68  E-value: 2.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  42 NASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGAalIVPQIL 121
Cdd:cd17472   28 GATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGA--ISSVVM 105

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497339922 122 ATLHITLKGTAHARAISLYGGIGGIAFIVGqMGGGWLVSADiagLGWRNAFFINVPICLLVLAFSPRYVPETRREAHSR 200
Cdd:cd17472  106 ALLADLTREENRTKAMALIGASIGIAFAIS-MVLGPLLAAH---LGVSGLFLITAILSLVSLLILLFFVPDPPKIVQIS 180
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
33-195 3.57e-08

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 55.31  E-value: 3.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  33 ALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAG 112
Cdd:PRK11102  13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 113 AALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVsadiAGLGWRNAFFI----NVPICLLVLAFSPR 188
Cdd:PRK11102  93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLL----VWFSWHAIFWVlalaAILAAALVFFFIPE 168


                 ....*..
gi 497339922 189 YVPETRR 195
Cdd:PRK11102 169 TLPKERR 175
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 27-186 7.39e-08

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 54.12  E-value: 7.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  27 TSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAAR 106
Cdd:cd17323   15 SSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 107 AVQGAGAAliVPQILATLHITLKGTAHAR--AISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAFFINVPICLLVLA 184
Cdd:cd17323   95 FLQGFFGS--SPLAIGAGTIADLFTPEERgkAMGVYSLGPLLGPALGPIIGGFITQS----LGWRWIFWFLAIISGFCLI 168


                 ..
gi 497339922 185 FS 186
Cdd:cd17323  169 LI 170
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 13-429 1.72e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 53.00  E-value: 1.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  13 LFLLLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMW-----GVAIFG 87
Cdd:cd06173    1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  88 VASLLCGMANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLvsadIAGLG 167
Cdd:cd06173   81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLL----VALLG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 168 WRNAFFINVPICLLVLAFSPRYVPETRREAHSRIDWQGTFSLALILCCLLFPMalgpelhwpwtlqlmlaavlpllvwmr 247
Cdd:cd06173  157 PGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPL--------------------------- 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 248 asalskqqrgeqpllpprllkltsIRFGMAIALLFFSAWSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFISALYAP 327
Cdd:cd06173  210 ------------------------LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLG 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 328 KLIARYSMGRILLTGLSVQIVGLLLLSATFYrlgihttTLALVPSTALIGYGQALIVNSFYRIGMRDISASDAGAGSAIL 407
Cdd:cd06173  266 RLSKRRRRGRLLLIGALLLGLALLVLGLSPS-------LWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVY 338

                        410       420
                 ....*....|....*....|..
gi 497339922 408 STLQQATLGLGPAILGSLFLTL 429
Cdd:cd06173  339 NALNSGAMPLGALLAGLLADAL 360
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 25-186 1.58e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 49.89  E-value: 1.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  25 IDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLA 104
Cdd:cd17365   13 FDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 105 ARAVQGAGAALIVPQILATLHITLKGTAHARAISL-YGGIGgiafiVGQMGGGWLVSADIAGLGWRNAFFIN--VPICLL 181
Cdd:cd17365   93 LRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLmFCGYP-----LGAALGGFLAAALIPAFGWRSVFLLGgvPPLILL 167


                 ....*
gi 497339922 182 VLAFS 186
Cdd:cd17365  168 PLLRG 172
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 13-195 2.15e-06

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 49.93  E-value: 2.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  13 LFLLLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLL 92
Cdd:cd17328    1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  93 CGMANSITTLLAARAVQGAGAALIVPqILATLHITL-KGTAHARAISLYGGIGGIAFIVGQMGGGWLVSADiagLGWRNA 171
Cdd:cd17328   81 SSFAPNFWQLLLFRALVGIGEASYSP-IAPTIIADLfPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAT---GGWRWA 156

                        170       180
                 ....*....|....*....|....
gi 497339922 172 FFINVPICLLVLAFSPRYVPETRR 195
Cdd:cd17328  157 FRVTGVLGVLLAILLLLFVREPPR 180
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 64-326 3.18e-06

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 49.19  E-value: 3.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  64 AMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGAALIVPQILATLHITLKGTAHARAIS-LYGG 142
Cdd:PRK11551  68 LLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSlMYCG 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 143 I---GGIAFIVGQMGGGwlvsadiaGLGWRNAFFIN-------VPICLLVLAFSPRYVPETRREAHSRIDWQGTFS---- 208
Cdd:PRK11551 148 VpfgGALASVIGVLAAG--------DAAWRHIFYVGgvgplllVPLLMRWLPESRAFAQAAGAGKQRAPVLRALFGegra 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 209 ---LALILCCLLFPMALGPELHWpwtlqlmlaavLPLLvwMRASALSKQQRGEQPLLPPRLLKLTSIRFGMAIALLFFSA 285
Cdd:PRK11551 220 tatLLLWISYFFTLIVLYFLLNW-----------LPSL--LVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRR 286

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 497339922 286 WSGFMFCMALTMQAGLGMAPWQSGNSFIALGVAYFI----SALYA 326
Cdd:PRK11551 287 VVLLIYAGILASLAALAAAPSFAGMLLAGFAAGLFVvggqSVLYA 331
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 26-195 3.68e-06

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 49.11  E-value: 3.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  26 DTSIANVALDSITQSLN--ASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLL 103
Cdd:cd17315   12 DLGVINGALLYIAKDLGfgLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 104 AARAVQGAGAALIVpqILATLHITlkGTAHARAISLYGGIGGIAFIVGQMGGGW--LVSADIAGLGWRNAFFINVPICLL 181
Cdd:cd17315   92 VGRFLLGLGVGLAS--VLVPLYIS--EIAPAKIRGALGTLNQLMITFGILLAYLlgLALSLSPPGWWRLMFALAAVPALL 167

                        170
                 ....*....|....
gi 497339922 182 vLAFSPRYVPETRR 195
Cdd:cd17315  168 -QLLLMFFLPESRA 180
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 11-231 4.13e-06

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 49.16  E-value: 4.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  11 AGLFLLLTGQMLPLIDTSianVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSkLGDNYGRRRLFMWGVAIFGVAS 90
Cdd:cd06179    1 AALCLAYFAQLFGVTLPA---AVLPFIVADLGPSSNSTWISTAWSLAQAVLGPIVGR-LSDLFGRRWFFIGGNLLGVVGS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  91 LLCGMANSITTLLAARAVQGAGAALIVPQILATLHItLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSADIAglGWRN 170
Cdd:cd06179   77 IVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASEL-VPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAA--GWRW 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 171 AFFINVP------ICLLVLAFSPRYV---PETRREAHSRIDWQGTFSLALILCCLLFPMALGPELhWPWT 231
Cdd:cd06179  154 IFYINAIfnalalILLFFFYHPPPRPqlhGSSTRQKLKRLDWVGLFLLIAGLVLFLLGLSWGGNP-YPWS 222
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 26-200 5.18e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 48.45  E-value: 5.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  26 DTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAA 105
Cdd:cd17371   14 DLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLIL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 106 RAVQGAG-------AALIVPQILATLHitlkgtaHARAISLYGGIGGIAFIVGQMGGGWLVSADIAGLGWRNAFFINVpI 178
Cdd:cd17371   94 RALAGLGfggewaaGAALMAEYVPARH-------RGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGA-L 165

                        170       180
                 ....*....|....*....|..
gi 497339922 179 CLLVLAFSPRYVPETRREAHSR 200
Cdd:cd17371  166 PALLVLFIRRFVKEPPQWQAAR 187
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 26-195 8.80e-06

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 47.65  E-value: 8.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  26 DTSIANVALDSITQSL---NASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTL 102
Cdd:cd17360   12 DTGVISGALLYIKDDLgevVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 103 LAARAVQGAG---AALIVPqilatLHITLKGTAHARA--ISLYGgiggiAFIVgqmgGGWLVSADIAGL------GWRNA 171
Cdd:cd17360   92 IVGRVLVGLGvgiASMTVP-----LYIAEAAPPRIRGrlVTINV-----LFIT----GGQFVAYVINGAfsylpgGWRWM 157

                        170       180       190
                 ....*....|....*....|....*....|
gi 497339922 172 FFIN-VP-----ICLLVLAFSPRYvPETRR 195
Cdd:cd17360  158 LGLAaVPavlqfIGLLFLPESPRW-PSTRR 186
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
34-199 2.56e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 46.40  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  34 LDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGA 113
Cdd:COG2807   41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 114 ALIvpQILATLHITLKGTAH-ARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAFFINVPICLLVLAFSPRYVPE 192
Cdd:COG2807  121 AVG--NVLLPGLIKRWFPDRvGLMTGLYTAAMGLGAALAAGLTVPLAAA----LGWRGALAVWALLALLALLLWLPLLRR 194


                 ....*..
gi 497339922 193 TRREAHS 199
Cdd:COG2807  195 RPAAAAA 201
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 41-188 3.26e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 46.07  E-value: 3.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  41 LNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGAALIVPQI 120
Cdd:cd06173  239 LGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPL 318

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497339922 121 LATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAFFINVPICLLVLAFSPR 188
Cdd:cd06173  319 NTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA----LGLSAVFLLAGALLLLAALLLLL 382
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 41-195 9.31e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 44.49  E-value: 9.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  41 LNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGAALIVPqI 120
Cdd:cd17330   29 LGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSV-A 107

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497339922 121 LATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAFFINVPICLLVLAFSPRYVPETRR 195
Cdd:cd17330  108 QAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP----YGYALPFLVAAALALLNLVLVLFFLPPLRR 178
Sugar_tr pfam00083
Sugar (and other) transporter;
38-360 9.77e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 44.57  E-value: 9.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   38 TQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITT---LLAARAVQGAGAA 114
Cdd:pfam00083  38 VSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSvyqLIVGRVLVGIGVG 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  115 LIvpQILATLHITLKGTAHARaiSLYGGIGGIAFIVGQMGG---GWLVSADIAGLGWRNAFFINVPICLLVLAFSPrYVP 191
Cdd:pfam00083 118 GA--SVLAPMYISEIAPKKLR--GALGSLYQLAITFGILLAyifGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLL-FLP 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  192 ETRR--EAHSRIDwQGTFSLAlilccllfpmalgpelhWPWTLQLmlaaVLPLLVWMRASALSKQQRGEQPLLPPRLLKL 269
Cdd:pfam00083 193 ESPRwlVEKGRLE-EAREVLA-----------------KLRGVPD----VDRELDEIKDSLEAGQEAEKASWKELFSTKT 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  270 TSIRFGMAIALLFFSAWSGFMFCM--ALTMQAGLGMAPWQSGNsfIALGVAYFISALYAPKLIARYSMGRILLTGLSVQI 347
Cdd:pfam00083 251 RRQRLLIGVMLQIFQQLTGINAIFyySTTIFENLGLSDSFLVT--IIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMA 328

                         330
                  ....*....|...
gi 497339922  348 VGLLLLSATFYRL 360
Cdd:pfam00083 329 ICFVILGIVALLG 341
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 37-201 1.05e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.53  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  37 ITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGAALI 116
Cdd:cd17329   26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 117 VPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSADIaglgwRNAFFINVPICLLVLAFSPRYVPETRRE 196
Cdd:cd17329  106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF-----RLLFLAAAVLFLLAALVLLFLLPETRPK 180


                 ....*
gi 497339922 197 AHSRI 201
Cdd:cd17329  181 RRAAE 185
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
33-113 1.24e-04

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 44.11  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  33 ALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAG 112
Cdd:PRK11043  28 AFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVG 107


                 .
gi 497339922 113 A 113
Cdd:PRK11043 108 V 108
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
37-195 1.31e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 44.09  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  37 ITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRR--LFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGAA 114
Cdd:COG2271  207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 115 LIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdiagLGWRNAFFINVPICLLVLAFSPRYVPETR 194
Cdd:COG2271  287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA----TGYQAAFLLLAALALLAALLALLLLRETR 362


                 .
gi 497339922 195 R 195
Cdd:COG2271  363 K 363
PRK12307 PRK12307
MFS transporter;
8-236 1.40e-04

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 44.15  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   8 PGRAGLFLLLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFG 87
Cdd:PRK12307  15 PQKNALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  88 VASLLCGMANSITTLLAARAVQGAGA----ALIVPQILATLHITLKGTAHARAISlyggiggiAFIVGQMGGGWLVSADI 163
Cdd:PRK12307  95 VGTGLSGLASGVIMLTLSRFIVGMGMageyACASTYAVESWPKHLKSKASAFLVS--------GFGIGNIIAAYFMPSFA 166

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497339922 164 AGLGWRNAFFINVPICLLVLAFSPRyVPETRREAHSRIDWQGTFSLALILCCLLFPMALGPELHWPWTLQLML 236
Cdd:PRK12307 167 EAYGWRAAFFVGLLPVLLVIYIRAR-APESKEWEEAKLSGKGKHSQSAWSVFSLSMKGLFNRAQFPLTLCVFI 238
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
38-196 2.01e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 43.69  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  38 TQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGAALIV 117
Cdd:COG0738  238 KDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMF 317

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497339922 118 PQILAtLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLvsADIAGLgwRNAFFINVPICLLVLAFSPRYVPETRRE 196
Cdd:COG0738  318 PTIFS-LALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFL--ADAFGL--RAAFLVPLVCYLLILLLALALKRKRRKK 391
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 40-354 3.46e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 43.02  E-value: 3.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  40 SLNASATQLELI----VALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITT---LLAARAVQGAG 112
Cdd:cd17357   39 GLNLSDSELDLLwsliVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKSpelLIFGRFLVGIA 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 113 AAL-IVPQILATLHIT---LKGTAHaraiSLYGGIGGIAFIVGQMGGgwLVSADIAGLGWRNAFFINVPICLLVLAFSPr 188
Cdd:cd17357  119 CGLsTGFVPMYLQEISpseLRGALG----SLTQIGVTLGILLGQVFG--LPSVLGTETLWPYLLFFPGIPALLQLAALP- 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 189 YVPETRR---EAHSRIDwQGTFSLALilccllfpmalgpelhwpwtLQLMLAAVLPLLVWMRASALSKQQRGEQPLLPPR 265
Cdd:cd17357  192 FFPESPKfllISKGDEE-EAEKSLKF--------------------LRGIEDDVDQELEEIKKESEQMGDQKQVSLMQLL 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 266 LLKLTSIRFGMAIALLFFSAWSGFM----FCMALTMQAGLGMAPWQSGNSFIalGVAYFISALYAPKLIARYSMGRILLT 341
Cdd:cd17357  251 RDPSLRLPLLLVLVVSASQQFSGINaiffYSTFIFENAGFSPQLAEWANLGI--GIVNVLSTIVGPFLIEKVGRRPLLLI 328

                        330
                 ....*....|...
gi 497339922 342 GLSVQIVGLLLLS 354
Cdd:cd17357  329 SLSVCAVALLLMS 341
emrD PRK11652
multidrug transporter EmrD;
33-194 5.33e-04

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 42.20  E-value: 5.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  33 ALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAG 112
Cdd:PRK11652  30 AIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 113 AAliVPQILA-TLHITL-KGTAHARAISLYGGigGIAF--IVGQMGGGWLVSAdiagLGWRNAFFINVPICLLVLAFSPR 188
Cdd:PRK11652 110 TG--VGGVMArTLPRDLyEGTQLRHANSLLNM--GILVspLLAPLIGGLLTTL----FGWRACYLFLLLLGAGVTFSMAR 181


                 ....*.
gi 497339922 189 YVPETR 194
Cdd:PRK11652 182 WMPETR 187
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 31-151 5.93e-04

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 42.24  E-value: 5.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  31 NVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANsITTLLAARAVQG 110
Cdd:cd17403   24 NVSITTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMGIGSLVFALPH-FTVFILAQLLHG 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 497339922 111 AGAAlivpqILATLHIT-LKGTAHARAISLYGGIGGIAFIVG 151
Cdd:cd17403  103 AGAT-----PLYTLGVTyLDENVSTKMSPLYIGIFYAMAILG 139
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
38-147 6.51e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.88  E-value: 6.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  38 TQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGAALIV 117
Cdd:COG2814  235 QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLF 314

                         90       100       110
                 ....*....|....*....|....*....|
gi 497339922 118 PQILATLHITLKGTAHARAISLYGGIGGIA 147
Cdd:COG2814  315 PLLQALVAELAPPEARGRASGLYNSAFFLG 344
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 33-230 6.67e-04

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 42.35  E-value: 6.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   33 ALDSITQSLNASATQlELIVALYGVAFAVCLAMGSKLGDNYGRRRlFMWGVAIFGVASLLCG-MANSITTLLAARAVQGA 111
Cdd:pfam06609  66 ALPNILQDIGQSENQ-GLFSTLWTMGQAVSILMMGRLTDRFGRRP-FVIATHIIGLVGAIVGcTANKFNTLLAAMTLLGV 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  112 GAAlivPQILATLHItlkGTAHARAISLYGGIGGIAFIVGQMGGGWLVSADIAGLG-WRNAFFI-----NVPICLLVLAF 185
Cdd:pfam06609 144 AAG---PAGASPLFI---GELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGnWRWIFYIyiimsAIAVLLIIIWY 217

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 497339922  186 SPRYVPE------TRREAHSRIDWQGTFSLALILCCLLFPMALGPELHWPW 230
Cdd:pfam06609 218 HPPSFAQlhgkkaRKRDELAKLDWIGIFLVIAGTSLFLLGVSWGGKPNNPW 268
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 37-218 8.68e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.39  E-value: 8.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  37 ITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGAALI 116
Cdd:cd17478   22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAF 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 117 VPQILATLHITLkGTAHARAISLYGGIGGIAFIVGQMGGGWLVSAdIAGLGWRNAFFINVPICLLVLAF----SPRYVPE 192
Cdd:cd17478  102 HPEGARLASQAA-GGRRGLAMSIFSVGGNLGFALGPLIAAALVAL-FGGLGLLILLIIPGLAVALLLLRlrplKKPEAKK 179

                        170       180
                 ....*....|....*....|....*.
gi 497339922 193 TRREAHSRIDWQGTFSLALILCCLLF 218
Cdd:cd17478  180 AAAKSSARSTLKGVWRALLLLLIIVF 205
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 47-123 1.01e-03

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 41.03  E-value: 1.01e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497339922  47 QLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAG--AALIVPQILAT 123
Cdd:cd17317   26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTsaGIFTVGFVLGM 104
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 44-186 1.41e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.00  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  44 SATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGAALIVPqILAT 123
Cdd:cd17324  232 SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHS-ALQT 310

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497339922 124 LHITLKGTAHARAISLYGGiggiAFIVGQMGGGWLVSADIAGLGWRNAFFINVPICLLVLAFS 186
Cdd:cd17324  311 RVLRLAPEARGLASSLYLA----AYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 42-223 1.96e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 40.23  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  42 NASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGAALIVPQIL 121
Cdd:cd17477   27 GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSE 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 122 ATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLVSADIAGLGWRNAFFInvpICLLVLAFSPRYVPETRREAHSRI 201
Cdd:cd17477  107 SWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLL---LALVPLLLTRRAAPEIEEAESISL 183

                        170       180
                 ....*....|....*....|..
gi 497339922 202 DWQGTFSLALILCCLLFPMALG 223
Cdd:cd17477  184 RRLLRIAPLALLGAFVAGFLEG 205
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
37-185 2.59e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 40.27  E-value: 2.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  37 ITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMA--NSITTLLAARAVQGAGAA 114
Cdd:COG2211  255 FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLG 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 115 LIVPQILATL-----HITLKGTAHARAI--SLYGGIGGIAFIVGQMGGGWLVSA----------DIAGLGWRNAFFInVP 177
Cdd:COG2211  335 AILVLPWAMLadvvdYDEWKTGRRREGLyfGIFTFAIKLGQALAGALAGLLLALfgyvagaaqsPSALTGIRLLFFL-LP 413


                 ....*...
gi 497339922 178 ICLLVLAF 185
Cdd:COG2211  414 AVLLLLAA 421
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 40-185 3.25e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 39.52  E-value: 3.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  40 SLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGA--GAALIV 117
Cdd:cd17390   25 SLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIfkHTQSLC 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497339922 118 PQILATLHITLKgtaHARAISLYGGIGGIAFIVGQMGGGWLVsadiaglGWRNAFFINVPICLLVLAF 185
Cdd:cd17390  105 KAYLSDLVSEQE---RSRVLGRFNAASSLGFILGPVVGGHLA-------ETDGGFYYVALLCSAIFIL 162
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
37-193 3.60e-03

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 39.54  E-value: 3.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  37 ITQSLNASATQLELIVALY---GVAFAVCLAmgsKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGA 113
Cdd:PRK15402  39 VVEDFNAGAEWVPTSMTAYlagGMFLQWLLG---PLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 114 ALIVPQILATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGgwlvSADIAGLGWRNAFFINVPICLLVLAFSPRYVPET 193
Cdd:PRK15402 116 CFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVG----AALIHVLPWRGMFVLFAALAALSFFGLWRAMPET 191
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 34-195 3.77e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 39.54  E-value: 3.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  34 LDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQG-AG 112
Cdd:cd17388   26 LREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGiTG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922 113 AALIVPQilATLHITLKGTAHARAISLYGGIGGIAFIVGQMGGGWLvsadiAGLGWRNAFFINVPICLLVLAFSPRYVPE 192
Cdd:cd17388  106 ATGAVAA--AYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLL-----GEISPRAPFLVAAGLNGLNFLLGLFVLPE 178


                 ...
gi 497339922 193 TRR 195
Cdd:cd17388  179 SLP 181
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 380-444 5.19e-03

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 39.68  E-value: 5.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 497339922  380 QALIVNSFYRIGMRDISASDAGAGSAILSTLQQATLGL--GPAILGSLFLTLAQRsgGDYPRALIDF 444
Cdd:PRK11447  262 QKQLADPAFRARAQGLAAVDSGQGGKAIPELQQAVRANpkDSEALGALGQAYSQQ--GDRARAVAQF 326
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 37-184 5.94e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 5.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  37 ITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFGVASLLCGMANSITTLLAARAVQGAGAALI 116
Cdd:cd17473  224 LQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLL 303

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497339922 117 VPQILATLHITLKGTAHARAISLYGGiggiAFIVGQMGGGWLVSADIAGLGWRNAFFINVPICLLVLA 184
Cdd:cd17473  304 LPTLNSWAMSLVPPELRGRAMGIVTS----AFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLA 367
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 8-188 9.46e-03

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 38.39  E-value: 9.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922   8 PGRAGLFLLLTGQMLPLIDTSIANVALDSITQSLNASATQLELIVALYGVAFAVCLAMGSKLGDNYGRRRLFMWGVAIFG 87
Cdd:cd17393  197 PNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAA 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339922  88 VASLLCGMANSITTLLAARAVQGAGAALIVPQILATLHiTLKGTAHARAISLYGGIGGIAFIVGQMGGGWLvsADIAGLG 167
Cdd:cd17393  277 LGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAG-ALPGLAAGIAVARVATLGYLGFLVGPPLIGFL--ADATGLR 353

                        170       180
                 ....*....|....*....|.
gi 497339922 168 WrnAFFINVPICLLVLAFSPR 188
Cdd:cd17393  354 T--AFLVVALLALLVALLARA 372
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH