|
Name |
Accession |
Description |
Interval |
E-value |
| phnR |
TIGR03337 |
phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of ... |
9-239 |
3.81e-138 |
|
phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of the GntR family (pfam00392) containing an N-terminal helix-turn-helix (HTH) motif. This clade is found adjacent to or inside of operons for the degradation of 2-aminoethylphosphonate (AEP) in Salmonella, Vibrio Aeromonas hydrophila, Hahella chejuensis and Psychromonas ingrahamii. [Regulatory functions, DNA interactions]
Pssm-ID: 132380 [Multi-domain] Cd Length: 231 Bit Score: 386.87 E-value: 3.81e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 9 PQYLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFVTPERLWLDPTQNTNF 88
Cdd:TIGR03337 1 PQYLYIKDHLSYQIRAGALLPGDKLPSERDLGERFNTTRVTIREALQQLEAEGLIYREDRRGWFVSPPRLRYNPTRTQNF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 89 HKLCLEQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQIYLLTRLRHADGRAICYCENHCLPARVPELLRHDLNGSLTEI 168
Cdd:TIGR03337 81 HEYVREQGREPKTELIGVTVTPAPARMAELLQLQPFDRLFLLQRLRYADGRPVCYCENYILPARVPGLLKEDLNGSLTEI 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497339638 169 YQTHYDLIYTSMHLSFWPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHDSLRIEVDTH 239
Cdd:TIGR03337 161 YRNHYGLVYHSMNLRFKPTALLEEAAQALGATAGLPALHLERTNYDQHGRVLDLDIEYWRHDALTIEVDTN 231
|
|
| MngR |
COG2188 |
DNA-binding transcriptional regulator, GntR family [Transcription]; |
5-237 |
9.86e-70 |
|
DNA-binding transcriptional regulator, GntR family [Transcription];
Pssm-ID: 441791 [Multi-domain] Cd Length: 238 Bit Score: 213.57 E-value: 9.86e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 5 SGETPQYLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFVTPERLWLDPTQ 84
Cdd:COG2188 1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 85 NTNFHKLCLEQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQIYLLTRLRHADGRAICYCENHCLPARVPELLRHDL-NG 163
Cdd:COG2188 81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLeTG 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497339638 164 SLTEIYQTHYDLIYTSMHLSFWPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHDSLRIEVD 237
Cdd:COG2188 161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVE 234
|
|
| UTRA |
pfam07702 |
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ... |
94-233 |
2.19e-36 |
|
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 429607 [Multi-domain] Cd Length: 141 Bit Score: 125.40 E-value: 2.19e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 94 EQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQIYLLTRLRHADGRAICYCENHCLPARVPELLRHDL-NGSLTEIYQTH 172
Cdd:pfam07702 1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLeEGSLYDYLEER 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497339638 173 YDLIYTSMHLSFWPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHDSLR 233
Cdd:pfam07702 81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
|
|
| UTRA |
smart00866 |
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ... |
94-230 |
7.11e-30 |
|
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.
Pssm-ID: 214869 [Multi-domain] Cd Length: 143 Bit Score: 108.53 E-value: 7.11e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 94 EQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQIYLLTRLRHADGRAICYCENHCLPARVPELLRHDLNGSLTEIYQTHY 173
Cdd:smart00866 1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 174 DL---IYTSMHLSFWPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHD 230
Cdd:smart00866 81 GLkivRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGD 140
|
|
| WHTH_GntR |
cd07377 |
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
9-74 |
6.36e-23 |
|
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.
Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 88.27 E-value: 6.36e-23
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497339638 9 PQYLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFVT 74
Cdd:cd07377 1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
|
|
| PRK11402 |
PRK11402 |
transcriptional regulator PhoB; |
8-179 |
2.89e-18 |
|
transcriptional regulator PhoB;
Pssm-ID: 183118 [Multi-domain] Cd Length: 241 Bit Score: 80.65 E-value: 2.89e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 8 TPQYLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFVTPERLWLDPTQNTN 87
Cdd:PRK11402 8 QLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 88 FHKLCLEQGREPKT-VLLDGRLAAVPLDVMapLALQPFDQIYLLTRLRHADGRAICYCENHCLPARVPELLRHDLNG-SL 165
Cdd:PRK11402 88 FTDFGVSQGKATKEkVIEQERVSAAPFCEK--LNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGsST 165
|
170
....*....|....
gi 497339638 166 TEIYQTHYDLIYTS 179
Cdd:PRK11402 166 YQLFQERFDTRVVS 179
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| phnR |
TIGR03337 |
phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of ... |
9-239 |
3.81e-138 |
|
phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of the GntR family (pfam00392) containing an N-terminal helix-turn-helix (HTH) motif. This clade is found adjacent to or inside of operons for the degradation of 2-aminoethylphosphonate (AEP) in Salmonella, Vibrio Aeromonas hydrophila, Hahella chejuensis and Psychromonas ingrahamii. [Regulatory functions, DNA interactions]
Pssm-ID: 132380 [Multi-domain] Cd Length: 231 Bit Score: 386.87 E-value: 3.81e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 9 PQYLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFVTPERLWLDPTQNTNF 88
Cdd:TIGR03337 1 PQYLYIKDHLSYQIRAGALLPGDKLPSERDLGERFNTTRVTIREALQQLEAEGLIYREDRRGWFVSPPRLRYNPTRTQNF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 89 HKLCLEQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQIYLLTRLRHADGRAICYCENHCLPARVPELLRHDLNGSLTEI 168
Cdd:TIGR03337 81 HEYVREQGREPKTELIGVTVTPAPARMAELLQLQPFDRLFLLQRLRYADGRPVCYCENYILPARVPGLLKEDLNGSLTEI 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497339638 169 YQTHYDLIYTSMHLSFWPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHDSLRIEVDTH 239
Cdd:TIGR03337 161 YRNHYGLVYHSMNLRFKPTALLEEAAQALGATAGLPALHLERTNYDQHGRVLDLDIEYWRHDALTIEVDTN 231
|
|
| MngR |
COG2188 |
DNA-binding transcriptional regulator, GntR family [Transcription]; |
5-237 |
9.86e-70 |
|
DNA-binding transcriptional regulator, GntR family [Transcription];
Pssm-ID: 441791 [Multi-domain] Cd Length: 238 Bit Score: 213.57 E-value: 9.86e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 5 SGETPQYLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFVTPERLWLDPTQ 84
Cdd:COG2188 1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 85 NTNFHKLCLEQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQIYLLTRLRHADGRAICYCENHCLPARVPELLRHDL-NG 163
Cdd:COG2188 81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLeTG 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497339638 164 SLTEIYQTHYDLIYTSMHLSFWPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHDSLRIEVD 237
Cdd:COG2188 161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVE 234
|
|
| UTRA |
pfam07702 |
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ... |
94-233 |
2.19e-36 |
|
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 429607 [Multi-domain] Cd Length: 141 Bit Score: 125.40 E-value: 2.19e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 94 EQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQIYLLTRLRHADGRAICYCENHCLPARVPELLRHDL-NGSLTEIYQTH 172
Cdd:pfam07702 1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLeEGSLYDYLEER 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497339638 173 YDLIYTSMHLSFWPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHDSLR 233
Cdd:pfam07702 81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
|
|
| UTRA |
smart00866 |
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ... |
94-230 |
7.11e-30 |
|
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.
Pssm-ID: 214869 [Multi-domain] Cd Length: 143 Bit Score: 108.53 E-value: 7.11e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 94 EQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQIYLLTRLRHADGRAICYCENHCLPARVPELLRHDLNGSLTEIYQTHY 173
Cdd:smart00866 1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 174 DL---IYTSMHLSFWPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHD 230
Cdd:smart00866 81 GLkivRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGD 140
|
|
| WHTH_GntR |
cd07377 |
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
9-74 |
6.36e-23 |
|
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.
Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 88.27 E-value: 6.36e-23
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497339638 9 PQYLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFVT 74
Cdd:cd07377 1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
|
|
| C_P_lyase_phnF |
TIGR02325 |
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ... |
11-235 |
7.22e-22 |
|
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]
Pssm-ID: 131378 [Multi-domain] Cd Length: 238 Bit Score: 90.23 E-value: 7.22e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 11 YLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFVTPERLWLDPTQNTNFHK 90
Cdd:TIGR02325 10 WRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFSQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 91 LCLEQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQIYLLTRLRHADGRAICYCENHCLPARVPELL-RHDLNGSLTEIY 169
Cdd:TIGR02325 90 NLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGqAYAASGSITDAL 169
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 170 --QTHYDLIYTSMHLSfwptSMPPQAAEA--LGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHDslRIE 235
Cdd:TIGR02325 170 reQGVADYRRSSTRIS----ARHADAKDCarLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRAD--RVE 233
|
|
| PRK11402 |
PRK11402 |
transcriptional regulator PhoB; |
8-179 |
2.89e-18 |
|
transcriptional regulator PhoB;
Pssm-ID: 183118 [Multi-domain] Cd Length: 241 Bit Score: 80.65 E-value: 2.89e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 8 TPQYLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFVTPERLWLDPTQNTN 87
Cdd:PRK11402 8 QLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 88 FHKLCLEQGREPKT-VLLDGRLAAVPLDVMapLALQPFDQIYLLTRLRHADGRAICYCENHCLPARVPELLRHDLNG-SL 165
Cdd:PRK11402 88 FTDFGVSQGKATKEkVIEQERVSAAPFCEK--LNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGsST 165
|
170
....*....|....
gi 497339638 166 TEIYQTHYDLIYTS 179
Cdd:PRK11402 166 YQLFQERFDTRVVS 179
|
|
| HTH_GNTR |
smart00345 |
helix_turn_helix gluconate operon transcriptional repressor; |
14-73 |
4.09e-18 |
|
helix_turn_helix gluconate operon transcriptional repressor;
Pssm-ID: 197669 [Multi-domain] Cd Length: 60 Bit Score: 75.30 E-value: 4.09e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 14 IKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFV 73
Cdd:smart00345 1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
|
|
| GntR |
pfam00392 |
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ... |
11-73 |
9.91e-18 |
|
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.
Pssm-ID: 306822 [Multi-domain] Cd Length: 64 Bit Score: 74.57 E-value: 9.91e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497339638 11 YLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFV 73
Cdd:pfam00392 2 YEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
|
|
| trehalos_R_Bsub |
TIGR02404 |
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ... |
10-170 |
8.07e-16 |
|
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]
Pssm-ID: 274116 [Multi-domain] Cd Length: 233 Bit Score: 73.94 E-value: 8.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 10 QYLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFV-TPERLWLDPTQNTNF 88
Cdd:TIGR02404 1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVlNRKQIEFPISGITSF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 89 HKLCLEQGREPKT-VLLDGRLAAVPLDVMAPLALQPFDQIYLLTRLRHADGRAICYCENHCLPARVPELLRHDLNGSlte 167
Cdd:TIGR02404 81 KELNETLGLDSKTeVVELDKEDPLPETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDS--- 157
|
...
gi 497339638 168 IYQ 170
Cdd:TIGR02404 158 IYQ 160
|
|
| FadR |
COG2186 |
DNA-binding transcriptional regulator, FadR family [Transcription]; |
3-79 |
1.41e-15 |
|
DNA-binding transcriptional regulator, FadR family [Transcription];
Pssm-ID: 441789 [Multi-domain] Cd Length: 232 Bit Score: 73.04 E-value: 1.41e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 497339638 3 SPSGETPQYLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFVTPERLW 79
Cdd:COG2186 1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPW 77
|
|
| ARO8 |
COG1167 |
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ... |
3-143 |
2.04e-15 |
|
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis
Pssm-ID: 440781 [Multi-domain] Cd Length: 471 Bit Score: 74.87 E-value: 2.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 3 SPSGETPQYLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFVTPeRLWLDP 82
Cdd:COG1167 6 DRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAA-RLPAPA 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497339638 83 TQNTNFHKLCLEQGREpktvLLDGRLAAVPLDVMAP-LALQPFDQIYLLTR--LRHADGRAICY 143
Cdd:COG1167 85 PAPRAAAAVAAPALRR----LLEAAPGVIDLGSGAPdPDLFPLAALRRALRraLRRLPPALLGY 144
|
|
| YhcF |
COG1725 |
DNA-binding transcriptional regulator YhcF, GntR family [Transcription]; |
3-75 |
6.69e-14 |
|
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
Pssm-ID: 441331 [Multi-domain] Cd Length: 114 Bit Score: 65.97 E-value: 6.69e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497339638 3 SPSGETPQYLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFVTP 75
Cdd:COG1725 4 DFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAE 76
|
|
| PRK09764 |
PRK09764 |
GntR family transcriptional regulator; |
6-233 |
6.46e-13 |
|
GntR family transcriptional regulator;
Pssm-ID: 182065 [Multi-domain] Cd Length: 240 Bit Score: 66.00 E-value: 6.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 6 GETPQYLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFVTPERLWLDPTQN 85
Cdd:PRK09764 2 GHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 86 TNFH-KLCLEQGREPKTVLLdgrLAAVPLD--VMAPLALQPFDQIYLLTRLRHADGRAICYcENHCLPARvpelLRHDLN 162
Cdd:PRK09764 82 TSFDeKLSDRHVDTHSEVLI---FEVIPADdfLQQQLQITAQDRVWHVKRVRYRKQKPMAL-EETWMPLA----LFPDLT 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497339638 163 GSLTEIYQTHY-----DLIYTSMHLSFWPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHDSLR 233
Cdd:PRK09764 154 WQVMENSKYHFieevkKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYK 229
|
|
| GntR |
COG1802 |
DNA-binding transcriptional regulator, GntR family [Transcription]; |
16-75 |
1.72e-10 |
|
DNA-binding transcriptional regulator, GntR family [Transcription];
Pssm-ID: 441407 [Multi-domain] Cd Length: 222 Bit Score: 58.78 E-value: 1.72e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 16 AQLQARIQNGALKSGDKLpSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFVTP 75
Cdd:COG1802 18 EALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP 76
|
|
| pdhR |
PRK09464 |
pyruvate dehydrogenase complex transcriptional repressor PdhR; |
14-79 |
3.20e-09 |
|
pyruvate dehydrogenase complex transcriptional repressor PdhR;
Pssm-ID: 181879 [Multi-domain] Cd Length: 254 Bit Score: 55.80 E-value: 3.20e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497339638 14 IKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFVTpERLW 79
Cdd:PRK09464 15 IEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQ-SSLW 79
|
|
| PRK10421 |
PRK10421 |
DNA-binding transcriptional repressor LldR; Provisional |
17-70 |
1.57e-08 |
|
DNA-binding transcriptional repressor LldR; Provisional
Pssm-ID: 236690 [Multi-domain] Cd Length: 253 Bit Score: 53.62 E-value: 1.57e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 497339638 17 QLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIyrADRRG 70
Cdd:PRK10421 10 RVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVL--LSRRG 61
|
|
| PRK03837 |
PRK03837 |
transcriptional regulator NanR; Provisional |
16-63 |
3.58e-08 |
|
transcriptional regulator NanR; Provisional
Pssm-ID: 235166 [Multi-domain] Cd Length: 241 Bit Score: 52.33 E-value: 3.58e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 497339638 16 AQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVI 63
Cdd:PRK03837 20 ERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLV 67
|
|
| PRK10079 |
PRK10079 |
phosphonate metabolism transcriptional regulator PhnF; Provisional |
4-230 |
1.70e-07 |
|
phosphonate metabolism transcriptional regulator PhnF; Provisional
Pssm-ID: 182227 [Multi-domain] Cd Length: 241 Bit Score: 50.54 E-value: 1.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 4 PSGETPQYLLIKAQLQARIQnGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFVTPERLWLDPT 83
Cdd:PRK10079 7 PTSYPTRYQEIAAKLEQELR-QHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYPLN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 84 QNTNFHKLCLEQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQIYLLTRLRHADGRAICYCeNHCLP-ARVPELLRHDLN 162
Cdd:PRK10079 86 AQARFSQNLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLI-DHYFAdLTWWPTLQRFDS 164
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497339638 163 GSLTEIYQTHydliyTSMHLSFWPTSMPPQAAEA-----LGVMEGRPALLLRRLNY-DQHGRILDYDIEYWRHD 230
Cdd:PRK10079 165 GSLHDFLREQ-----LGIALRRSQTRISARRAQAkesqlLEIPNMSPLLCVRTLNHrDGESSPAEYSVSLTRAD 233
|
|
| PRK09990 |
PRK09990 |
DNA-binding transcriptional regulator GlcC; Provisional |
22-142 |
3.97e-06 |
|
DNA-binding transcriptional regulator GlcC; Provisional
Pssm-ID: 182186 [Multi-domain] Cd Length: 251 Bit Score: 46.68 E-value: 3.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 22 IQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFVTpeRLWLDPTQNTNFHKLcleqGREPKT 101
Cdd:PRK09990 20 IVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVA--RLNRVQDASPLMHLF----SSQPRT 93
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497339638 102 V--------LLDG---RLAAV---PLDVM-----------APLALQPFDQIYlLTRLRHADGRAIC 142
Cdd:PRK09990 94 LydllevraLLEGesaRLAALrgtQADFVlitrryeemlaAHENNKEIDPIE-HARLDHAFHLAIC 158
|
|
| PRK14999 |
PRK14999 |
histidine utilization repressor; Provisional |
2-73 |
6.17e-06 |
|
histidine utilization repressor; Provisional
Pssm-ID: 184961 [Multi-domain] Cd Length: 241 Bit Score: 46.08 E-value: 6.17e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 497339638 2 KSPSGETPQYLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYRADRRGWFV 73
Cdd:PRK14999 5 RSRSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFV 76
|
|
| PRK10225 |
PRK10225 |
Uxu operon transcriptional regulator; |
1-70 |
1.32e-05 |
|
Uxu operon transcriptional regulator;
Pssm-ID: 182318 [Multi-domain] Cd Length: 257 Bit Score: 45.01 E-value: 1.32e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 1 MKSPSGETPQYLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVIyrADRRG 70
Cdd:PRK10225 1 MKSATSAQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLV--EVRRG 68
|
|
| PRK11523 |
PRK11523 |
transcriptional regulator ExuR; |
11-63 |
2.01e-05 |
|
transcriptional regulator ExuR;
Pssm-ID: 183176 [Multi-domain] Cd Length: 253 Bit Score: 44.45 E-value: 2.01e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 497339638 11 YLLIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLESSGVI 63
Cdd:PRK11523 10 YQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYV 62
|
|
| HTH_41 |
pfam14502 |
Helix-turn-helix domain; |
28-70 |
1.80e-03 |
|
Helix-turn-helix domain;
Pssm-ID: 433997 [Multi-domain] Cd Length: 48 Bit Score: 35.55 E-value: 1.80e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 497339638 28 KSGDKLPSERELCALFNTTRITVRESLAQLESSGVIYrADRRG 70
Cdd:pfam14502 1 KAGERLPTISEYSHKFELSVGTVQKALKKLEDMKAIQ-LERRG 42
|
|
| PRK04984 |
PRK04984 |
fatty acid metabolism transcriptional regulator FadR; |
2-71 |
5.19e-03 |
|
fatty acid metabolism transcriptional regulator FadR;
Pssm-ID: 179909 [Multi-domain] Cd Length: 239 Bit Score: 37.16 E-value: 5.19e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497339638 2 KSPSGETPQYLlIKAqlqarIQNGALKSGDKLPSERELCALFNTTRITVREslaqlessgVIYRADRRGW 71
Cdd:PRK04984 6 QSPAGFAEEYI-IES-----IWNNRFPPGSILPAERELSELIGVTRTTLRE---------VLQRLARDGW 60
|
|
| |
