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Conserved domains on  [gi|497293940|ref|WP_009608157|]
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MULTISPECIES: molybdopterin-dependent oxidoreductase [Eggerthella]

Protein Classification

molybdopterin-binding protein( domain architecture ID 1861)

molybdopterin-binding protein similar to sulfite oxidase and nitrite reductase that catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate

Gene Ontology:  GO:0043546
PubMed:  9242907

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MsrP super family cl30135
Molybdopterin-dependent catalytic subunit of periplasmic DMSO/TMAO and ...
 284-421 6.94e-18

Molybdopterin-dependent catalytic subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases [Energy production and conversion];


The actual alignment was detected with superfamily member COG2041:

Pssm-ID: 441644 [Multi-domain]  Cd Length: 183  Bit Score: 81.74  E-value: 6.94e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 284 ENWVISIDGDCENPVEMTLPEMeQQFGTVKQVMKMDCTINGVGqatiMQSEVEGIPLKAIIDYAKPKSGANVVSPIGSD- 362
Cdd:COG2041   33 ADWRLRVDGLVEKPLTLTLDDL-LALPLEERIYRLHCVENWSG----GVAPWTGVPLRDLLERAGPKPGAKYVLFESADp 107

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 497293940 363 GYdYAKMGIDWLLENDAVIVTKMDGELLPNSQGYPCMIWVNKTSGGNFTKRISNLTFMT 421
Cdd:COG2041  108 GY-TESLPLDEALDPDTLLAYGMNGEPLPPEHGAPLRLVVPGLYGFKSAKWLVRIEVTD 165
 
Name Accession Description Interval E-value
MsrP COG2041
Molybdopterin-dependent catalytic subunit of periplasmic DMSO/TMAO and ...
 284-421 6.94e-18

Molybdopterin-dependent catalytic subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases [Energy production and conversion];


Pssm-ID: 441644 [Multi-domain]  Cd Length: 183  Bit Score: 81.74  E-value: 6.94e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 284 ENWVISIDGDCENPVEMTLPEMeQQFGTVKQVMKMDCTINGVGqatiMQSEVEGIPLKAIIDYAKPKSGANVVSPIGSD- 362
Cdd:COG2041   33 ADWRLRVDGLVEKPLTLTLDDL-LALPLEERIYRLHCVENWSG----GVAPWTGVPLRDLLERAGPKPGAKYVLFESADp 107

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 497293940 363 GYdYAKMGIDWLLENDAVIVTKMDGELLPNSQGYPCMIWVNKTSGGNFTKRISNLTFMT 421
Cdd:COG2041  108 GY-TESLPLDEALDPDTLLAYGMNGEPLPPEHGAPLRLVVPGLYGFKSAKWLVRIEVTD 165
SO_family_Moco cd00321
Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) ...
 284-397 1.59e-16

Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Assimilatory NRs catalyze the reduction of nitrate to nitrite which is subsequently converted to NH4+ by nitrite reductase. Common features of all known members of this family are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate.


Pssm-ID: 238198 [Multi-domain]  Cd Length: 156  Bit Score: 76.84  E-value: 1.59e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 284 ENWVISIDGDCENPVEMTLPEMeQQFGTVKQVMKMDCTINGVGQATIMQSEVEGIPLKAIIDYAKPKSGANVVSPIGSDG 363
Cdd:cd00321   15 DDWRLEVDGLVEKPLSLTLDDL-KALPQVEVIATLHCVGNRWGGGAVSNAEWTGVPLRDLLEEAGPKPGARYVVFEGADD 93

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 497293940 364 YDYAKMG----IDWLLENDAVIVTKMDGELLPNSQGYP 397
Cdd:cd00321   94 PGGDGYTtslpLEKALDPDVLLAYEMNGEPLPPDHGFP 131
Oxidored_molyb pfam00174
Oxidoreductase molybdopterin binding domain; This domain is found in a variety of ...
 284-397 1.61e-16

Oxidoreductase molybdopterin binding domain; This domain is found in a variety of oxidoreductases. This domain binds to a molybdopterin cofactor. Xanthine dehydrogenases, that also bind molybdopterin, have essentially no similarity.


Pssm-ID: 459699 [Multi-domain]  Cd Length: 168  Bit Score: 77.16  E-value: 1.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940  284 ENWVISIDGDCENPVEMTLPEMeQQFGTVKQVMKMDCTING-----------VGQATIMQSEVEGIPLKAIIDYAKPKSG 352
Cdd:pfam00174  10 DTWRLRVDGLVEKPLTLTLDDL-KAFPQVTVTATLQCVGNRrkemnrvkgvqWGGGAIGNAEWTGVPLRDLLERAGVKPG 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 497293940  353 ANVVSPIGSDGYDYAKMG----IDWLLENDAVIVTKMDGELLPNSQGYP 397
Cdd:pfam00174  89 AKHVLFEGADTLGDGGYTtslpLEKALDDDVLLAYEMNGEPLPPDHGYP 137
PRK05363 PRK05363
protein-methionine-sulfoxide reductase catalytic subunit MsrP;
284-397 6.25e-04

protein-methionine-sulfoxide reductase catalytic subunit MsrP;


Pssm-ID: 235431  Cd Length: 280  Bit Score: 41.74  E-value: 6.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 284 ENWVISIDGDCENPVEMTLPEMEQQFGTVKQVMKMDCtingvgqatimqseVE---------GIPLKAIIDYAKPKSGAN 354
Cdd:PRK05363  61 DPWTVKIDGEVEKPGTLDIDDLLKLFPLEERIYRLRC--------------VEawsmvipwiGFPLAKLLKRVEPTSNAK 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 497293940 355 VVSPIGSdgYDYAKM-G-----IDW-------LLE--ND-AVIVTKMDGELLPNSQGYP 397
Cdd:PRK05363 127 YVAFETL--YDPEQMpGqrsrfLDWpyveglrLDEamHPlTLLAVGLYGKTLPNQNGAP 183
 
Name Accession Description Interval E-value
MsrP COG2041
Molybdopterin-dependent catalytic subunit of periplasmic DMSO/TMAO and ...
 284-421 6.94e-18

Molybdopterin-dependent catalytic subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases [Energy production and conversion];


Pssm-ID: 441644 [Multi-domain]  Cd Length: 183  Bit Score: 81.74  E-value: 6.94e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 284 ENWVISIDGDCENPVEMTLPEMeQQFGTVKQVMKMDCTINGVGqatiMQSEVEGIPLKAIIDYAKPKSGANVVSPIGSD- 362
Cdd:COG2041   33 ADWRLRVDGLVEKPLTLTLDDL-LALPLEERIYRLHCVENWSG----GVAPWTGVPLRDLLERAGPKPGAKYVLFESADp 107

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 497293940 363 GYdYAKMGIDWLLENDAVIVTKMDGELLPNSQGYPCMIWVNKTSGGNFTKRISNLTFMT 421
Cdd:COG2041  108 GY-TESLPLDEALDPDTLLAYGMNGEPLPPEHGAPLRLVVPGLYGFKSAKWLVRIEVTD 165
SO_family_Moco cd00321
Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) ...
 284-397 1.59e-16

Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Assimilatory NRs catalyze the reduction of nitrate to nitrite which is subsequently converted to NH4+ by nitrite reductase. Common features of all known members of this family are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate.


Pssm-ID: 238198 [Multi-domain]  Cd Length: 156  Bit Score: 76.84  E-value: 1.59e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 284 ENWVISIDGDCENPVEMTLPEMeQQFGTVKQVMKMDCTINGVGQATIMQSEVEGIPLKAIIDYAKPKSGANVVSPIGSDG 363
Cdd:cd00321   15 DDWRLEVDGLVEKPLSLTLDDL-KALPQVEVIATLHCVGNRWGGGAVSNAEWTGVPLRDLLEEAGPKPGARYVVFEGADD 93

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 497293940 364 YDYAKMG----IDWLLENDAVIVTKMDGELLPNSQGYP 397
Cdd:cd00321   94 PGGDGYTtslpLEKALDPDVLLAYEMNGEPLPPDHGFP 131
Oxidored_molyb pfam00174
Oxidoreductase molybdopterin binding domain; This domain is found in a variety of ...
 284-397 1.61e-16

Oxidoreductase molybdopterin binding domain; This domain is found in a variety of oxidoreductases. This domain binds to a molybdopterin cofactor. Xanthine dehydrogenases, that also bind molybdopterin, have essentially no similarity.


Pssm-ID: 459699 [Multi-domain]  Cd Length: 168  Bit Score: 77.16  E-value: 1.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940  284 ENWVISIDGDCENPVEMTLPEMeQQFGTVKQVMKMDCTING-----------VGQATIMQSEVEGIPLKAIIDYAKPKSG 352
Cdd:pfam00174  10 DTWRLRVDGLVEKPLTLTLDDL-KAFPQVTVTATLQCVGNRrkemnrvkgvqWGGGAIGNAEWTGVPLRDLLERAGVKPG 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 497293940  353 ANVVSPIGSDGYDYAKMG----IDWLLENDAVIVTKMDGELLPNSQGYP 397
Cdd:pfam00174  89 AKHVLFEGADTLGDGGYTtslpLEKALDDDVLLAYEMNGEPLPPDHGYP 137
SO_family_Moco_dimer cd02110
Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved ...
 284-530 1.24e-15

Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO).


Pssm-ID: 239028 [Multi-domain]  Cd Length: 317  Bit Score: 78.11  E-value: 1.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 284 ENWVISIDGDCENPVEMTLPEMeQQFGTVKQVMKMDCTINGVGQATIMQSEVE------------GIPLKAIIDYAKPKS 351
Cdd:cd02110   16 DAWRLEIHGLVERPLTLTLDDL-KRLPSVEVVATLECSGNGRGGFIPVRSGAQwghgavgnarwtGVPLKDLLEEAGVKP 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 352 GANVVSPIGSDGY------DYAK-MGIDWLLENDAVIVTKMDGELLPNSQGYPCMIWVNKTSGGNFTKRISNLTFMTVP- 423
Cdd:cd02110   95 GAKHVLFEGADVPpgekaaDYTRsVPLSKALDDDALLAYEMNGEPLPPDHGYPLRLVVPGWYGARSVKWLRRIEVTDQPs 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 424 DDKIDAELYVGQFTDDRTGEIYSKPNSGVLNYPTGI--VLSGEE---AKTVHLEGFADAWDEPIKKMEFSFDHGETWTVV 498
Cdd:cd02110  175 DGYWQTRDYTVPPPDVDAVGGKARRPIGEMPVKSVItsPSPGAElvsGGRVEIGGVAWSGGRGIRRVEVSLDGGRTWQEA 254

                        250       260       270
                 ....*....|....*....|....*....|....
gi 497293940 499 DT--PDNNADNWTYWRMDFTPPaAGAYLLDIRTT 530
Cdd:cd02110  255 RLegPLAGPRAWRQWELDWDLP-PGEYELVARAT 287
bact_SorA_Moco cd02114
sulfite:cytochrome c oxidoreductase subunit A (SorA), molybdopterin binding domain. SorA is ...
 288-530 3.81e-15

sulfite:cytochrome c oxidoreductase subunit A (SorA), molybdopterin binding domain. SorA is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SorB, a small c-type heme containing subunit, it forms a hetrodimer. It is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). Common features of all known members of this family are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate.


Pssm-ID: 239032 [Multi-domain]  Cd Length: 367  Bit Score: 77.17  E-value: 3.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 288 ISIDGDCENPVEMTLPEMEQQFGTVKQVMKMDCTING------------VGQATIMQSEVEGIPLKAIIDYAKPKSGANV 355
Cdd:cd02114   67 LTIDGKVRTPLTLSLAELKRIEPRFEVVAVNQCSGNSrgffqprvqgaqLANGAMGNARWAGVPLKAVLAKAGVQDGARQ 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 356 VSPIGSDG------YDYAK-MGIDWLLENDAVIVTKMDGELLPNSQGYPCMIWVNKTSGGNFTKRISNLTFMTVPDDKID 428
Cdd:cd02114  147 VAFRGLDQpvldvtPDFVKsLDIDHALDGEVMLAWEMNGEPLPVLNGYPLRLVVPGFYATYWVKHLSHITVLDKEFDGFW 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 429 AEL-YVGQFTDDRTGEIYSKPN-----------SGVLNYPTG-IVLSGEEaktVHLEGFADAWDEPIKKMEFSFDHGETW 495
Cdd:cd02114  227 ASQaYRIPDNADAGVEPGTAPDrtapinrfkvrSFITSLENGaIVAPAGE---LALRGIAFDGGSGIRRVDVSADGGDSW 303

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 497293940 496 TVVDT-PDNNADNWTYWRMDFTPPAAGAYLLDIRTT 530
Cdd:cd02114  304 TQATLgPDLGRFSFRGWKLTLDGVKKGPLTLMVRAT 339
arch_bact_SO_family_Moco cd02109
bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding ...
 284-397 1.50e-10

bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). Common features of all known members of this family are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate. The specific function of this subgroup is unknown.


Pssm-ID: 239027 [Multi-domain]  Cd Length: 180  Bit Score: 60.34  E-value: 1.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 284 ENWVISIDGDCENPVEMTLPEmeqqfgtvkqVMKMDCT-----INGVGQATIMQSEVEGIPLKAIIDYAKPKSGANVVSP 358
Cdd:cd02109   25 EKWRLRVTGLVENPLSLTYED----------LLALPQTeytadFHCVTGWSKLDVVWEGVSLKDLLEAARPDPEATFVMA 94

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 497293940 359 IGSDGYDyAKMGIDWLLENDAVIVTKMDGELLPNSQGYP 397
Cdd:cd02109   95 HSYDGYT-TNLPLEDLLREDSLLATKMDGEPLPPEHGGP 132
eukary_NR_Moco cd02112
molybdopterin binding domain of eukaryotic nitrate reductase (NR). Assimilatory NRs catalyze ...
 283-514 1.87e-05

molybdopterin binding domain of eukaryotic nitrate reductase (NR). Assimilatory NRs catalyze the reduction of nitrate to nitrite which is subsequently converted to NH4+ by nitrite reductase. Eukaryotic assimilatory nitrate reductases are cytosolic homodimeric enzymes with three prosthetic groups, flavin adenine dinucleotide (FAD), cytochrome b557, and Mo cofactor, which are located in three functional domains. Common features of all known members of the sulfite oxidase (SO) family of molybdopterin binding domains are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate.


Pssm-ID: 239030 [Multi-domain]  Cd Length: 386  Bit Score: 46.99  E-value: 1.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 283 YENWVISIDGDCENPVEMTLPEMEQQFGTVKQVMKMDCTIN--------------GVGQATIMQSEVEGIPLKAIIDYAK 348
Cdd:cd02112   58 WEDWTVEVTGLVEKPTTLTMDELVAMFPSVTFPVTLVCAGNrrkeqnmvkktigfNWGAAGTSTSLWTGVRLSDLLDRCG 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 349 PKS---GANVVSPIGSDGYDYAKMG-------IDWLL--ENDAVIVTKMDGELLPNSQGYPCMIWVNKTSGGNFTKRISN 416
Cdd:cd02112  138 PKSpkgGARHVCFEGADDLLPGPNGkygtsitLSWAMdpSKDVMLAYKQNGELLHPDHGFPVRLIIPGQIGGRMVKWLKR 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 417 LTFMTVPDDK-------------IDAELYvgqfTDDRtgeIYSKPNSGV--LNYPTGIVLSGEE----------AKTVHL 471
Cdd:cd02112  218 IVVSDRESQNhyhfhdnrvlpshVDAELA----NEEG---WWYKPEYIIndLNVNSAITTPAHDevlplnglttAETYTM 290

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 497293940 472 EGFADAW-DEPIKKMEFSFDHGETWTV--VDTPDNNADN-----WTYWRMD 514
Cdd:cd02112  291 KGYAYAGgGRRVTRVEVSLDDGKSWKLasIDYPEDPTKYgkcwcWCFWSLD 341
YedY_like_Moco cd02107
YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) ...
 261-397 9.26e-05

YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been proposed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY, which is likely membrane-anchored by a heme-containing trans-membrane subunit YedZ. Preliminary results indicate that YedY may represent a new type of membrane-associated bacterial reductase. Common features of all known members of this family are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate.


Pssm-ID: 239025 [Multi-domain]  Cd Length: 218  Bit Score: 43.98  E-value: 9.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 261 FKTVKDEPSqwltddSKQDKSIYENWVISIDGDCENPVEMTLPEMEQQFGTVKQVMKMDCTingvgQATIMQSEVEGIPL 340
Cdd:cd02107    9 FGTGKDDPA------RNAGNLPTRPWTVSVSGLVKKPKTLDIDDLMKTFPLEERIYRFRCV-----EGWSMVVPWVGFPL 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497293940 341 KAIIDYAKPKSGANVVS---------------PIGSDGYDYAK-MGIDWLLENDAVIVTKMDGELLPNSQGYP 397
Cdd:cd02107   78 AALLARAEPTSEAKYVRfttlldkeqmpgqsgLFGVLPWPYVEgLRLDEAMHPLTLLAVGLYGEALPKQNGAP 150
bact_SoxC_Moco cd02113
bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. ...
 290-496 5.29e-04

bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a hetrotetrameric sulfite dehydrogenase. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). Common features of all known members of this family are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate.


Pssm-ID: 239031 [Multi-domain]  Cd Length: 326  Bit Score: 42.39  E-value: 5.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 290 IDGDCENPVEMTLPEMeQQFGTVKQVMKMDC-----------TINGVGQATIMQSEVE--GIPLKAIIDYAKPKSGANVV 356
Cdd:cd02113   35 IHGMVKKPLVFTMDDL-KRFPSVSRIYFLECsgnggtgwrgaPLPTAQYTHGMLSCSEwtGVPLSTLLEEAGVKPGAKWL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 357 SPIGSDGYDYAK-MGIDWLLEnDAVIVTKMDGELLPNSQGYPCMIWVNKTSGGNFTK-----RISNLTFMT--------- 421
Cdd:cd02113  114 LAEGADAAAMTRsIPLEKALD-DALVAYAQNGEALRPENGYPLRLVVPGWEGNTNVKwlrriEVGDQPWMTreetskytd 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 422 -VPDDKidaelyVGQFTddrtgeIYSKPNSgVLNYPTGivlsgeeAKTVHLEGFAD----AWD--EPIKKMEFSFDHGET 494
Cdd:cd02113  193 lLPDGR------ARQFS------FVMEAKS-VITSPSG-------GQRLREPGFHEisglAWSgrGRIRRVDVSFDGGRT 252


                 ..
gi 497293940 495 WT 496
Cdd:cd02113  253 WQ 254
PRK05363 PRK05363
protein-methionine-sulfoxide reductase catalytic subunit MsrP;
284-397 6.25e-04

protein-methionine-sulfoxide reductase catalytic subunit MsrP;


Pssm-ID: 235431  Cd Length: 280  Bit Score: 41.74  E-value: 6.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293940 284 ENWVISIDGDCENPVEMTLPEMEQQFGTVKQVMKMDCtingvgqatimqseVE---------GIPLKAIIDYAKPKSGAN 354
Cdd:PRK05363  61 DPWTVKIDGEVEKPGTLDIDDLLKLFPLEERIYRLRC--------------VEawsmvipwiGFPLAKLLKRVEPTSNAK 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 497293940 355 VVSPIGSdgYDYAKM-G-----IDW-------LLE--ND-AVIVTKMDGELLPNSQGYP 397
Cdd:PRK05363 127 YVAFETL--YDPEQMpGqrsrfLDWpyveglrLDEamHPlTLLAVGLYGKTLPNQNGAP 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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