NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|497293937|ref|WP_009608154|]
View 

MULTISPECIES: GNAT family N-acetyltransferase [Eggerthella]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 18514852)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  15581578|9175471|10940244
SCOP:  3000403

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 94-164 2.09e-17

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 73.15  E-value: 2.09e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497293937  94 PDEVLVVHVLGTLPAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTTNVRAQSLYESCGFANCGVCEGFY 164
Cdd:COG0456   10 GGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYY 80
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-169 1.80e-15

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


:

Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 70.02  E-value: 1.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293937   1 MLKVRRARADEFDQVLDFYTNMIDGMRGTefdvcWEHDVHPSS---AFLRASVDAGEVYVGLVEDGEgatciasamVLng 77
Cdd:COG1247    1 EMTIRPATPEDAPAIAAIYNEAIAEGTAT-----FETEPPSEEereAWFAAILAPGRPVLVAEEDGE---------VV-- 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293937  78 egdaGYESVSWHVAAAPDEVLVVHVLGTLPAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTTNVRAQSLYESCGFANC 157
Cdd:COG1247   65 ----GFASLGPFRPRPAYRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEV 140

                        170
                 ....*....|..
gi 497293937 158 GVCEGFYDRLGR 169
Cdd:COG1247  141 GTLPEVGFKFGR 152
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 94-164 2.09e-17

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 73.15  E-value: 2.09e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497293937  94 PDEVLVVHVLGTLPAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTTNVRAQSLYESCGFANCGVCEGFY 164
Cdd:COG0456   10 GGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYY 80
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-169 1.80e-15

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 70.02  E-value: 1.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293937   1 MLKVRRARADEFDQVLDFYTNMIDGMRGTefdvcWEHDVHPSS---AFLRASVDAGEVYVGLVEDGEgatciasamVLng 77
Cdd:COG1247    1 EMTIRPATPEDAPAIAAIYNEAIAEGTAT-----FETEPPSEEereAWFAAILAPGRPVLVAEEDGE---------VV-- 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293937  78 egdaGYESVSWHVAAAPDEVLVVHVLGTLPAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTTNVRAQSLYESCGFANC 157
Cdd:COG1247   65 ----GFASLGPFRPRPAYRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEV 140

                        170
                 ....*....|..
gi 497293937 158 GVCEGFYDRLGR 169
Cdd:COG1247  141 GTLPEVGFKFGR 152
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 94-154 6.59e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 59.45  E-value: 6.59e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497293937   94 PDEVLVVHVLGTLPAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTTNVRAQSLYESCGF 154
Cdd:pfam00583  56 EPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAAIALYEKLGF 116
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 107-164 6.56e-09

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 51.56  E-value: 6.56e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 497293937  107 PAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTTNVRAQSLYESCGFANCGVCEGFY 164
Cdd:TIGR01575  64 PEYQGQGIGRALLRELIDEAKGRGVNEIFLEVRVSNIAAQALYKKLGFNEIAIRRNYY 121
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 86-137 1.10e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 44.19  E-value: 1.10e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 497293937  86 VSWHVAAAPDEVLVVHVLGTLPAYHGRGFARAMMEACIDVARAAGKRAVRLD 137
Cdd:cd04301   14 ASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 107-154 1.52e-05

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 42.61  E-value: 1.52e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 497293937 107 PAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTTNVRAQSLYESCGF 154
Cdd:PRK09491  73 PDYQRQGLGRALLEHLIDELEKRGVATLWLEVRASNAAAIALYESLGF 120
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 94-164 2.09e-17

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 73.15  E-value: 2.09e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497293937  94 PDEVLVVHVLGTLPAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTTNVRAQSLYESCGFANCGVCEGFY 164
Cdd:COG0456   10 GGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYY 80
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-169 1.80e-15

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 70.02  E-value: 1.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293937   1 MLKVRRARADEFDQVLDFYTNMIDGMRGTefdvcWEHDVHPSS---AFLRASVDAGEVYVGLVEDGEgatciasamVLng 77
Cdd:COG1247    1 EMTIRPATPEDAPAIAAIYNEAIAEGTAT-----FETEPPSEEereAWFAAILAPGRPVLVAEEDGE---------VV-- 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293937  78 egdaGYESVSWHVAAAPDEVLVVHVLGTLPAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTTNVRAQSLYESCGFANC 157
Cdd:COG1247   65 ----GFASLGPFRPRPAYRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEV 140

                        170
                 ....*....|..
gi 497293937 158 GVCEGFYDRLGR 169
Cdd:COG1247  141 GTLPEVGFKFGR 152
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 94-154 9.90e-15

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 67.39  E-value: 9.90e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497293937  94 PDEVLVVHVLGTLPAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTTNVRAQSLYESCGF 154
Cdd:COG0454   55 DDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNPAAIRFYERLGF 115
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 94-154 6.59e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 59.45  E-value: 6.59e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497293937   94 PDEVLVVHVLGTLPAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTTNVRAQSLYESCGF 154
Cdd:pfam00583  56 EPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAAIALYEKLGF 116
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
4-158 2.82e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 58.17  E-value: 2.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293937   4 VRRARADEFDQVLDFYTNmidgmrgtEFDVCWEHDvhpSSAFLRASVDAGEVYVgLVEDGEgatCIASAMVlngegdagy 83
Cdd:COG3153    1 IRPATPEDAEAIAALLRA--------AFGPGREAE---LVDRLREDPAAGLSLV-AEDDGE---IVGHVAL--------- 56

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497293937  84 esvSWHVAAAPDEVLVVHVLGTLPAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTTNVRaqsLYESCGFANCG 158
Cdd:COG3153   57 ---SPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLP---FYERFGFRPAG 125
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 94-154 2.36e-10

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 55.38  E-value: 2.36e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497293937  94 PDEVLVVHVLGTLPAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTTnvrAQSLYESCGF 154
Cdd:COG1246   49 DEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSA---AIHFYEKLGF 106
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
90-154 3.10e-10

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 54.14  E-value: 3.10e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497293937  90 VAAAPDEVLVVHVLGTLPAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTTNVRAQSLYESCGF 154
Cdd:COG3393    8 VRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYERLGF 72
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 107-177 1.18e-09

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 54.62  E-value: 1.18e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 497293937 107 PAYHGRGFARAMMEACIDVARAA-GKRAVRLDTFTTNVRAQSLYESCGFANCGVCEGFYDRLGRSAVMYEYA 177
Cdd:COG1670   97 PAYWGKGYATEALRALLDYAFEElGLHRVEAEVDPDNTASIRVLEKLGFRLEGTLRDALVIDGRYRDHVLYS 168
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 107-164 6.56e-09

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 51.56  E-value: 6.56e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 497293937  107 PAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTTNVRAQSLYESCGFANCGVCEGFY 164
Cdd:TIGR01575  64 PEYQGQGIGRALLRELIDEAKGRGVNEIFLEVRVSNIAAQALYKKLGFNEIAIRRNYY 121
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
82-158 5.03e-08

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 49.41  E-value: 5.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293937  82 GYESVSWHVAAAPDEVLV----VHVLG----------TLPAYHGRGFARAMMEACIDVARAAGKRAVRLDtftTNVRAQS 147
Cdd:COG2153   29 GKDEDARHLLAYDDGELVatarLLPPGdgeakigrvaVLPEYRGQGLGRALMEAAIEEARERGARRIVLS---AQAHAVG 105

                         90
                 ....*....|.
gi 497293937 148 LYESCGFANCG 158
Cdd:COG2153  106 FYEKLGFVPVG 116
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 95-154 1.72e-07

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 46.68  E-value: 1.72e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293937   95 DEVLVVHVLGTLPAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTtnvRAQSLYESCGF 154
Cdd:pfam13508  26 EGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTN---RAAAFYEKLGF 82
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 86-137 1.10e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 44.19  E-value: 1.10e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 497293937  86 VSWHVAAAPDEVLVVHVLGTLPAYHGRGFARAMMEACIDVARAAGKRAVRLD 137
Cdd:cd04301   14 ASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 107-154 1.52e-05

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 42.61  E-value: 1.52e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 497293937 107 PAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTTNVRAQSLYESCGF 154
Cdd:PRK09491  73 PDYQRQGLGRALLEHLIDELEKRGVATLWLEVRASNAAAIALYESLGF 120
PRK10975 PRK10975
dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;
103-154 3.66e-05

dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;


Pssm-ID: 182877  Cd Length: 194  Bit Score: 42.22  E-value: 3.66e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 497293937 103 LGTLPAYHGRGFARAMMEACIDVARAAGKRAVRLDTFTTNVRAQSLYESCGF 154
Cdd:PRK10975 132 LAVFPGAQGRGIGARLMQAALNWCQARGLTRLRVATQMGNLAALRLYIRSGA 183
Acetyltransf_CG pfam14542
GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both ...
 107-134 1.18e-03

GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.


Pssm-ID: 434030 [Multi-domain]  Cd Length: 79  Bit Score: 36.34  E-value: 1.18e-03
                          10        20
                  ....*....|....*....|....*...
gi 497293937  107 PAYHGRGFARAMMEACIDVARAAGKRAV 134
Cdd:pfam14542  33 PALRGQGIASKLVKAALDDAREEGLKIV 60
Acetyltransf_3 pfam13302
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 107-154 1.25e-03

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 379112 [Multi-domain]  Cd Length: 139  Bit Score: 37.33  E-value: 1.25e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 497293937  107 PAYHGRGFARAMMEACIDVA-RAAGKRAVRLDTFTTNVRAQSLYESCGF 154
Cdd:pfam13302  90 PDYWGKGYATEAVRALLEYAfEELGLPRLVARIDPENTASRRVLEKLGF 138
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 100-159 1.61e-03

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 36.87  E-value: 1.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 497293937  100 VHVLGTLPAYHGRGFARAMMEACIDvarAAGKRAVRLDTFTTN--VRAQSLYESCGFANCGV 159
Cdd:pfam13673  54 ISLLFVDPDYQGQGIGKALLEAVED---YAEKDGIKLSELTVNasPYAVPFYEKLGFRATGP 112
YidJ COG2388
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
93-134 9.14e-03

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 441953 [Multi-domain]  Cd Length: 88  Bit Score: 33.98  E-value: 9.14e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 497293937  93 APDEVLVVHVlGTLPAYHGRGFARAMMEACIDVARAAGKRAV 134
Cdd:COG2388   29 EGGVIIITHT-EVPPALRGQGIASALVEAALDDARERGLKVV 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH