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Conserved domains on  [gi|497172822|ref|WP_009496323|]
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MULTISPECIES: folate family ECF transporter S component [Weissella]

Protein Classification

ECF transporter S component family protein( domain architecture ID 229498)

ECF transporter S component family protein is an integral membrane subunit that captures the substrate of an energy coupling factor (ECF) transporter

Gene Ontology:  GO:0035796|GO:0022857
PubMed:  30485755|22574898

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ECF_trnsprt super family cl21488
ECF transporter, substrate-specific component; Energy-coupling factor (ECF) transporters ...
 38-172 6.15e-16

ECF transporter, substrate-specific component; Energy-coupling factor (ECF) transporters consist of a substrate-specific component (known as the S component), and an energy-coupling module. The substrate-binding component is a small integral membrane protein which captures specific substrates and forms an active transporter in the presence of the energy-coupling AT module.


The actual alignment was detected with superfamily member TIGR04518:

Pssm-ID: 473881 [Multi-domain]  Cd Length: 162  Bit Score: 71.06  E-value: 6.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497172822   38 FLKIGFGFIIVAVIAHWFGPYWGVLTAIVQDLISTAINGHAFFF-GFMISAILGALIYGISFYNREH-ISWVRTMVTVAL 115
Cdd:TIGR04518  30 NLRISFGFLPVILAGMLFGPVAGAIVGAVADLLGCMLFGYGTFFpGFTLSAALTGLIYGLFFYKKKNkKLFLRLAAAVVI 109

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 497172822  116 VLLIVNTILNTLWVIMMGNITdpnaIMKMIEIRGLKQIMMFPIQVVLIHTILNNKSL 172
Cdd:TIGR04518 110 VQIIISLVLTSIWLSILYGSP----LTALLPIRLIKAIIMIPVEIVVIYLLLKNLAK 162
 
Name Accession Description Interval E-value
ECF_S_folT_fam TIGR04518
ECF transporter S component, folate family; Members of this model are the multiple ...
 38-172 6.15e-16

ECF transporter S component, folate family; Members of this model are the multiple membrane-spanning S (specificity) component of ECF (energy coupling factor) type uptake transporters. All seed members were found in the vicinity of the bifunctional enzyme folC, involved in making active cofactor from imported folate. However, some species have multiple members of this family, suggesting some diversity of function. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 275311 [Multi-domain]  Cd Length: 162  Bit Score: 71.06  E-value: 6.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497172822   38 FLKIGFGFIIVAVIAHWFGPYWGVLTAIVQDLISTAINGHAFFF-GFMISAILGALIYGISFYNREH-ISWVRTMVTVAL 115
Cdd:TIGR04518  30 NLRISFGFLPVILAGMLFGPVAGAIVGAVADLLGCMLFGYGTFFpGFTLSAALTGLIYGLFFYKKKNkKLFLRLAAAVVI 109

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 497172822  116 VLLIVNTILNTLWVIMMGNITdpnaIMKMIEIRGLKQIMMFPIQVVLIHTILNNKSL 172
Cdd:TIGR04518 110 VQIIISLVLTSIWLSILYGSP----LTALLPIRLIKAIIMIPVEIVVIYLLLKNLAK 162
ECF_trnsprt pfam12822
ECF transporter, substrate-specific component; Energy-coupling factor (ECF) transporters ...
 39-167 1.68e-03

ECF transporter, substrate-specific component; Energy-coupling factor (ECF) transporters consist of a substrate-specific component (known as the S component), and an energy-coupling module. The substrate-binding component is a small integral membrane protein which captures specific substrates and forms an active transporter in the presence of the energy-coupling AT module.


Pssm-ID: 432808  Cd Length: 157  Bit Score: 37.28  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497172822   39 LKIGFGFIIVAVIAHWFGPYWGVLTAIVQDLISTAINGHA---FFFGFMISAILGALIYGISFYNREHISWVRTMVTVaL 115
Cdd:pfam12822  27 LKIDLSHIPALLGALLLGPLAGILIGLLTSLLSALTTGGGgptGEPANFLPGILIGLVAGYLYKYGRNKKKKRILLAL-I 105

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 497172822  116 VLLIVNTILNTLWVIMMGNITDPNAIMKMIEIRGLKQIMMFPIQVVLIHTIL 167
Cdd:pfam12822 106 LGTILGTLVATLLNLLLILPFGPLLFAALLLPVLPFNLIEGIIAAILVPVLY 157
 
Name Accession Description Interval E-value
ECF_S_folT_fam TIGR04518
ECF transporter S component, folate family; Members of this model are the multiple ...
 38-172 6.15e-16

ECF transporter S component, folate family; Members of this model are the multiple membrane-spanning S (specificity) component of ECF (energy coupling factor) type uptake transporters. All seed members were found in the vicinity of the bifunctional enzyme folC, involved in making active cofactor from imported folate. However, some species have multiple members of this family, suggesting some diversity of function. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 275311 [Multi-domain]  Cd Length: 162  Bit Score: 71.06  E-value: 6.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497172822   38 FLKIGFGFIIVAVIAHWFGPYWGVLTAIVQDLISTAINGHAFFF-GFMISAILGALIYGISFYNREH-ISWVRTMVTVAL 115
Cdd:TIGR04518  30 NLRISFGFLPVILAGMLFGPVAGAIVGAVADLLGCMLFGYGTFFpGFTLSAALTGLIYGLFFYKKKNkKLFLRLAAAVVI 109

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 497172822  116 VLLIVNTILNTLWVIMMGNITdpnaIMKMIEIRGLKQIMMFPIQVVLIHTILNNKSL 172
Cdd:TIGR04518 110 VQIIISLVLTSIWLSILYGSP----LTALLPIRLIKAIIMIPVEIVVIYLLLKNLAK 162
ECF_trnsprt pfam12822
ECF transporter, substrate-specific component; Energy-coupling factor (ECF) transporters ...
 39-167 1.68e-03

ECF transporter, substrate-specific component; Energy-coupling factor (ECF) transporters consist of a substrate-specific component (known as the S component), and an energy-coupling module. The substrate-binding component is a small integral membrane protein which captures specific substrates and forms an active transporter in the presence of the energy-coupling AT module.


Pssm-ID: 432808  Cd Length: 157  Bit Score: 37.28  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497172822   39 LKIGFGFIIVAVIAHWFGPYWGVLTAIVQDLISTAINGHA---FFFGFMISAILGALIYGISFYNREHISWVRTMVTVaL 115
Cdd:pfam12822  27 LKIDLSHIPALLGALLLGPLAGILIGLLTSLLSALTTGGGgptGEPANFLPGILIGLVAGYLYKYGRNKKKKRILLAL-I 105

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 497172822  116 VLLIVNTILNTLWVIMMGNITDPNAIMKMIEIRGLKQIMMFPIQVVLIHTIL 167
Cdd:pfam12822 106 LGTILGTLVATLLNLLLILPFGPLLFAALLLPVLPFNLIEGIIAAILVPVLY 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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