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Conserved domains on  [gi|496957285|ref|WP_009419679|]
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MULTISPECIES: transcriptional regulator [Capnocytophaga]

Protein Classification

winged helix-turn-helix domain-containing protein( domain architecture ID 10612879)

winged helix-turn-helix (wHTH) domain-containing protein binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10473770|8831795
SCOP:  3000034

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_34 pfam13601
Winged helix DNA-binding domain;
13-92 4.93e-34

Winged helix DNA-binding domain;


:

Pssm-ID: 463932 [Multi-domain]  Cd Length: 80  Bit Score: 111.96  E-value: 4.93e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496957285  13 LRLAIVSLLVSEEKADFARIKEITKATSGNISVQIQKLETAGYITVKKSFKDNYPNTEVQLTKEGLLAFERYVEALKSYI 92
Cdd:pfam13601  1 VRLAIMSYLASVDEADFVELKEALEATDGNLSVHLRKLEKAGYIECDKSFVGRKPRTLYRITPEGREAFEDYVKALKRLI 80
 
Name Accession Description Interval E-value
HTH_34 pfam13601
Winged helix DNA-binding domain;
13-92 4.93e-34

Winged helix DNA-binding domain;


Pssm-ID: 463932 [Multi-domain]  Cd Length: 80  Bit Score: 111.96  E-value: 4.93e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496957285  13 LRLAIVSLLVSEEKADFARIKEITKATSGNISVQIQKLETAGYITVKKSFKDNYPNTEVQLTKEGLLAFERYVEALKSYI 92
Cdd:pfam13601  1 VRLAIMSYLASVDEADFVELKEALEATDGNLSVHLRKLEKAGYIECDKSFVGRKPRTLYRITPEGREAFEDYVKALKRLI 80
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
10-94 5.28e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 36.49  E-value: 5.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496957285  10 HSQLRlaIVSLLVSEEKADFARIKEITKATSGNISVQIQKLETAGYITVKKSFKDNyPNTEVQLTKEGLLAFERYVEALK 89
Cdd:COG1846   38 PAQFR--VLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDR-RAVLVRLTEKGRALLEEARPALE 114


                 ....*
gi 496957285  90 SYISR 94
Cdd:COG1846  115 ALLAE 119
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 8-60 1.64e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.20  E-value: 1.64e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 496957285  8 ILHSQLRLAIVSLLVSEEKAdFARIKEITKATSGNISVQIQKLETAGYITVKK 60
Cdd:cd00090   3 ALSDPTRLRILRLLLEGPLT-VSELAERLGLSQSTVSRHLKKLEEAGLVESRR 54
PRK13777 PRK13777
HTH-type transcriptional regulator Hpr;
30-91 9.12e-03

HTH-type transcriptional regulator Hpr;


Pssm-ID: 237501  Cd Length: 185  Bit Score: 33.48  E-value: 9.12e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496957285  30 ARIKEITK------ATSGNISvqiQKLETAGYITVKKSFKDNYpNTEVQLTKEGLlafERYVEALKSY 91
Cdd:PRK13777  60 ASISEIAKfgvmhvSTAFNFS---KKLEERGYLTFSKKEDDKR-NTYIELTEKGE---ELLLETMEEY 120
 
Name Accession Description Interval E-value
HTH_34 pfam13601
Winged helix DNA-binding domain;
13-92 4.93e-34

Winged helix DNA-binding domain;


Pssm-ID: 463932 [Multi-domain]  Cd Length: 80  Bit Score: 111.96  E-value: 4.93e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496957285  13 LRLAIVSLLVSEEKADFARIKEITKATSGNISVQIQKLETAGYITVKKSFKDNYPNTEVQLTKEGLLAFERYVEALKSYI 92
Cdd:pfam13601  1 VRLAIMSYLASVDEADFVELKEALEATDGNLSVHLRKLEKAGYIECDKSFVGRKPRTLYRITPEGREAFEDYVKALKRLI 80
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
10-94 5.28e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 36.49  E-value: 5.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496957285  10 HSQLRlaIVSLLVSEEKADFARIKEITKATSGNISVQIQKLETAGYITVKKSFKDNyPNTEVQLTKEGLLAFERYVEALK 89
Cdd:COG1846   38 PAQFR--VLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDR-RAVLVRLTEKGRALLEEARPALE 114


                 ....*
gi 496957285  90 SYISR 94
Cdd:COG1846  115 ALLAE 119
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 8-60 1.64e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.20  E-value: 1.64e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 496957285  8 ILHSQLRLAIVSLLVSEEKAdFARIKEITKATSGNISVQIQKLETAGYITVKK 60
Cdd:cd00090   3 ALSDPTRLRILRLLLEGPLT-VSELAERLGLSQSTVSRHLKKLEEAGLVESRR 54
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
1-57 2.08e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 35.25  E-value: 2.08e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 496957285   1 MFADLDPILHSQLRLAIVSLLvSEEKADFARIKEITKATSGNISVQIQKLETAGYIT 57
Cdd:COG4742    5 KLDLLDFLFLSEKRKNILLLL-AEGPKTRSELAESLDVSRSTILRQLKELEERGLIE 60
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 13-63 6.90e-03

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 32.13  E-value: 6.90e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 496957285  13 LRLAIVSLLVSEEKADFARIKEITKATSGNISVQIQKLETAGYITVKKSFK 63
Cdd:pfam12840 11 TRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
PRK13777 PRK13777
HTH-type transcriptional regulator Hpr;
30-91 9.12e-03

HTH-type transcriptional regulator Hpr;


Pssm-ID: 237501  Cd Length: 185  Bit Score: 33.48  E-value: 9.12e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496957285  30 ARIKEITK------ATSGNISvqiQKLETAGYITVKKSFKDNYpNTEVQLTKEGLlafERYVEALKSY 91
Cdd:PRK13777  60 ASISEIAKfgvmhvSTAFNFS---KKLEERGYLTFSKKEDDKR-NTYIELTEKGE---ELLLETMEEY 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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