NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|496843501|ref|WP_009382824|]
View 

molybdopterin-guanine dinucleotide biosynthesis protein B [Staphylococcus massiliensis]

Protein Classification

molybdopterin-guanine dinucleotide biosynthesis protein B( domain architecture ID 10004478)

molybdopterin-guanine dinucleotide biosynthesis protein B catalyzes the attachment of the guanine dinucleotide to molybdopterin

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MobB COG1763
Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; ...
 2-113 4.18e-39

Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; Molybdopterin-guanine dinucleotide biosynthesis protein is part of the Pathway/BioSystem: Molybdopterin biosynthesis


:

Pssm-ID: 441369 [Multi-domain]  Cd Length: 162  Bit Score: 129.91  E-value: 4.18e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496843501   2 ILQIVGYKNSGKTTLVEHSVKLLKAQGYRVVTVKHHGHEGD-DislEQGVDHMKHFEAGADQSIVQGHQVQQTVTRT-DN 79
Cdd:COG1763    3 VLGIVGYSGSGKTTLLEKLIPELKARGLRVGTIKHAHHDFDiD---TPGKDSYRHREAGADEVLVASPERWALMTELpEE 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 496843501  80 TDLEAIIANSitIAYDIVIVEGFKKASYDKVILY 113
Cdd:COG1763   80 PSLDELLARL--DDVDLVLVEGFKHEPLPKIEVH 111
 
Name Accession Description Interval E-value
MobB COG1763
Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; ...
 2-113 4.18e-39

Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; Molybdopterin-guanine dinucleotide biosynthesis protein is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 441369 [Multi-domain]  Cd Length: 162  Bit Score: 129.91  E-value: 4.18e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496843501   2 ILQIVGYKNSGKTTLVEHSVKLLKAQGYRVVTVKHHGHEGD-DislEQGVDHMKHFEAGADQSIVQGHQVQQTVTRT-DN 79
Cdd:COG1763    3 VLGIVGYSGSGKTTLLEKLIPELKARGLRVGTIKHAHHDFDiD---TPGKDSYRHREAGADEVLVASPERWALMTELpEE 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 496843501  80 TDLEAIIANSitIAYDIVIVEGFKKASYDKVILY 113
Cdd:COG1763   80 PSLDELLARL--DDVDLVLVEGFKHEPLPKIEVH 111
mobB TIGR00176
molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor ...
 2-115 1.01e-38

molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor biosynthesis enzyme is similar to the urease accessory protein UreG and to the hydrogenase accessory protein HypB, both GTP hydrolases involved in loading nickel into the metallocenters of their respective target enzymes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


Pssm-ID: 272943 [Multi-domain]  Cd Length: 155  Bit Score: 128.65  E-value: 1.01e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496843501    2 ILQIVGYKNSGKTTLVEHSVKLLKAQGYRVVTVKHHGHegdDISLEQ-GVDHMKHFEAGADQSIVQGHQVQQTVTRT-DN 79
Cdd:TIGR00176   1 VLQIVGPKNSGKTTLIERLVKALKARGYRVATIKHDHH---DFDIDKnGKDSYRHREAGADQVIVASSRRYAFMHETqEE 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 496843501   80 TDLEAIIANSITiaYDIVIVEGFKKASYDKVILYNN 115
Cdd:TIGR00176  78 RDLEALLDRLPD--LDIILVEGFKDSPLPKIVVFRN 111
MobB cd03116
molybdopterin-guanine dinucleotide biosynthesis protein B; Molybdenum is an essential trace ...
 1-114 1.18e-31

molybdopterin-guanine dinucleotide biosynthesis protein B; Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In Escherichia coli, the synthesis of Moco involves genes from several loci: moa, mob, mod, moe and mog. The mob locus contains mobA and mobB genes. MobB catalyzes the attachment of the guanine dinucleotide to molybdopterin.


Pssm-ID: 349770 [Multi-domain]  Cd Length: 157  Bit Score: 110.81  E-value: 1.18e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496843501   1 MILQIVGYKNSGKTTLVEHSVKLLKAQGYRVVTVKHHGHEGD-DIsleQGVDHMKHFEAGADQSIV--QGHQVQQTVTRT 77
Cdd:cd03116    1 KIVGVVGKSGSGKTTLIEKLIPELKARGLRVAVIKHTHHGFDiDT---PGKDSYRHRQAGADAVLVssPNRLALIHERPE 77

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 496843501  78 DNTDLEAIIANSITiaYDIVIVEGFKKASYDKVILYN 114
Cdd:cd03116   78 WELTLLELLARFSD--VDLVLVEGFKKEPIPKIEVFR 112
MobB pfam03205
Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop.
 2-113 3.33e-28

Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop.


Pssm-ID: 427196 [Multi-domain]  Cd Length: 133  Bit Score: 101.09  E-value: 3.33e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496843501    2 ILQIVGYKNSGKTTLVEHSVKLLKAQGYRVVTVKHHGHEGD-DIsleQGVDHMKHFEAGADQSIVQGHQVQQTVTRTDN- 79
Cdd:pfam03205   1 ILGIVGWSGSGKTTLLEKLIPELKARGLRVGTIKHAHHGFDiDK---PGKDSWRHRKAGASEVLVASPGRWALMHELRDe 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 496843501   80 --TDLEAIIAnsiTIA-YDIVIVEGFKKASYDKVILY 113
Cdd:pfam03205  78 pePSLEELLA---RLSpVDLVLVEGFKKEPYPKIEVH 111
PRK14494 PRK14494
putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing ...
 2-105 1.63e-20

putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional


Pssm-ID: 237731 [Multi-domain]  Cd Length: 229  Bit Score: 83.88  E-value: 1.63e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496843501   2 ILQIVGYKNSGKTTLVEHSVKLLKAQGYRVVTVKHHGHEGDdislEQGVDHMKHFEAGADQSIVQGHqvQQTVTRTDNTD 81
Cdd:PRK14494   3 AIGVIGFKDSGKTTLIEKILKNLKERGYRVATAKHTHHEFD----KPDTDTYRFKKAGAEVVVVSTD--ETAAFLYDRMD 76

                         90       100
                 ....*....|....*....|....
gi 496843501  82 LEAIIAnsiTIAYDIVIVEGFKKA 105
Cdd:PRK14494  77 LNEILS---LLDADFLLIEGFKEL 97
 
Name Accession Description Interval E-value
MobB COG1763
Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; ...
 2-113 4.18e-39

Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; Molybdopterin-guanine dinucleotide biosynthesis protein is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 441369 [Multi-domain]  Cd Length: 162  Bit Score: 129.91  E-value: 4.18e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496843501   2 ILQIVGYKNSGKTTLVEHSVKLLKAQGYRVVTVKHHGHEGD-DislEQGVDHMKHFEAGADQSIVQGHQVQQTVTRT-DN 79
Cdd:COG1763    3 VLGIVGYSGSGKTTLLEKLIPELKARGLRVGTIKHAHHDFDiD---TPGKDSYRHREAGADEVLVASPERWALMTELpEE 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 496843501  80 TDLEAIIANSitIAYDIVIVEGFKKASYDKVILY 113
Cdd:COG1763   80 PSLDELLARL--DDVDLVLVEGFKHEPLPKIEVH 111
mobB TIGR00176
molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor ...
 2-115 1.01e-38

molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor biosynthesis enzyme is similar to the urease accessory protein UreG and to the hydrogenase accessory protein HypB, both GTP hydrolases involved in loading nickel into the metallocenters of their respective target enzymes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


Pssm-ID: 272943 [Multi-domain]  Cd Length: 155  Bit Score: 128.65  E-value: 1.01e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496843501    2 ILQIVGYKNSGKTTLVEHSVKLLKAQGYRVVTVKHHGHegdDISLEQ-GVDHMKHFEAGADQSIVQGHQVQQTVTRT-DN 79
Cdd:TIGR00176   1 VLQIVGPKNSGKTTLIERLVKALKARGYRVATIKHDHH---DFDIDKnGKDSYRHREAGADQVIVASSRRYAFMHETqEE 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 496843501   80 TDLEAIIANSITiaYDIVIVEGFKKASYDKVILYNN 115
Cdd:TIGR00176  78 RDLEALLDRLPD--LDIILVEGFKDSPLPKIVVFRN 111
MobB cd03116
molybdopterin-guanine dinucleotide biosynthesis protein B; Molybdenum is an essential trace ...
 1-114 1.18e-31

molybdopterin-guanine dinucleotide biosynthesis protein B; Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In Escherichia coli, the synthesis of Moco involves genes from several loci: moa, mob, mod, moe and mog. The mob locus contains mobA and mobB genes. MobB catalyzes the attachment of the guanine dinucleotide to molybdopterin.


Pssm-ID: 349770 [Multi-domain]  Cd Length: 157  Bit Score: 110.81  E-value: 1.18e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496843501   1 MILQIVGYKNSGKTTLVEHSVKLLKAQGYRVVTVKHHGHEGD-DIsleQGVDHMKHFEAGADQSIV--QGHQVQQTVTRT 77
Cdd:cd03116    1 KIVGVVGKSGSGKTTLIEKLIPELKARGLRVAVIKHTHHGFDiDT---PGKDSYRHRQAGADAVLVssPNRLALIHERPE 77

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 496843501  78 DNTDLEAIIANSITiaYDIVIVEGFKKASYDKVILYN 114
Cdd:cd03116   78 WELTLLELLARFSD--VDLVLVEGFKKEPIPKIEVFR 112
MobB pfam03205
Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop.
 2-113 3.33e-28

Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop.


Pssm-ID: 427196 [Multi-domain]  Cd Length: 133  Bit Score: 101.09  E-value: 3.33e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496843501    2 ILQIVGYKNSGKTTLVEHSVKLLKAQGYRVVTVKHHGHEGD-DIsleQGVDHMKHFEAGADQSIVQGHQVQQTVTRTDN- 79
Cdd:pfam03205   1 ILGIVGWSGSGKTTLLEKLIPELKARGLRVGTIKHAHHGFDiDK---PGKDSWRHRKAGASEVLVASPGRWALMHELRDe 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 496843501   80 --TDLEAIIAnsiTIA-YDIVIVEGFKKASYDKVILY 113
Cdd:pfam03205  78 pePSLEELLA---RLSpVDLVLVEGFKKEPYPKIEVH 111
PRK14494 PRK14494
putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing ...
 2-105 1.63e-20

putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional


Pssm-ID: 237731 [Multi-domain]  Cd Length: 229  Bit Score: 83.88  E-value: 1.63e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496843501   2 ILQIVGYKNSGKTTLVEHSVKLLKAQGYRVVTVKHHGHEGDdislEQGVDHMKHFEAGADQSIVQGHqvQQTVTRTDNTD 81
Cdd:PRK14494   3 AIGVIGFKDSGKTTLIEKILKNLKERGYRVATAKHTHHEFD----KPDTDTYRFKKAGAEVVVVSTD--ETAAFLYDRMD 76

                         90       100
                 ....*....|....*....|....
gi 496843501  82 LEAIIAnsiTIAYDIVIVEGFKKA 105
Cdd:PRK14494  77 LNEILS---LLDADFLLIEGFKEL 97
PRK14489 PRK14489
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB; ...
 3-112 3.07e-17

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB; Provisional


Pssm-ID: 237727 [Multi-domain]  Cd Length: 366  Bit Score: 76.71  E-value: 3.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496843501   3 LQIVGYKNSGKTTLVEHSVKLLKAQGYRVVTVKHHGHEGD-DISleqGVDHMKHFEAGADQSIVQGHQVQQTVTRTDN-- 79
Cdd:PRK14489 208 LGVVGYSGTGKTTLLEKLIPELIARGYRIGLIKHSHHRVDiDKP---GKDSHRLRAAGANPTMIVCPERWALMRETPEea 284

                         90       100       110
                 ....*....|....*....|....*....|...
gi 496843501  80 TDLEAIIANSITIAYDIVIVEGFKKASYDKVIL 112
Cdd:PRK14489 285 VPFKVLIATFDPEEVDLILVEGFKHEPLPKIQL 317
PRK14491 PRK14491
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ...
 2-113 1.06e-14

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional


Pssm-ID: 237729 [Multi-domain]  Cd Length: 597  Bit Score: 70.03  E-value: 1.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496843501   2 ILQIVGYKNSGKTTLVEHSVKLLKAQGYRVVTVKHHGHEGD-DIsleQGVDHMKHFEAGADQSIVQGHQVQQTVT---RT 77
Cdd:PRK14491  12 LLGFCAYSGTGKTTLLEQLIPELNQRGLRLAVIKHAHHNFDvDQ---PGKDSYRLRKAGASQMLVASRVRWALMTetpRD 88

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 496843501  78 DNTDLEAIIANSITIAYDIVIVEGFKKASYDKVILY 113
Cdd:PRK14491  89 GEPELPHLLKQIDADKVDIVLVEGFKKLALPKIELH 124
PRK14493 PRK14493
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; ...
 2-112 9.78e-14

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; Provisional


Pssm-ID: 237730 [Multi-domain]  Cd Length: 274  Bit Score: 66.18  E-value: 9.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496843501   2 ILQIVGYKNSGKTTLVEHSVKLLKAQGyRVVTVKHHGHEGDDislEQGVDHMKHFEAGADQSIvqGHQVQQTVTRTDNTD 81
Cdd:PRK14493   3 VLSIVGYKATGKTTLVERLVDRLSGRG-RVGTVKHMDTERLN---PDGTDTGRHFDAGADVVY--GLTDGEWVASGRDRS 76

                         90       100       110
                 ....*....|....*....|....*....|.
gi 496843501  82 LEAIIANsITIAYDIVIVEGFKKASYDKVIL 112
Cdd:PRK14493  77 LDDALDD-LAPGMDYAVVEGFKDSRLPKVVL 106
PRK10751 PRK10751
molybdopterin-guanine dinucleotide biosynthesis protein B; Provisional
 2-116 9.01e-13

molybdopterin-guanine dinucleotide biosynthesis protein B; Provisional


Pssm-ID: 236750 [Multi-domain]  Cd Length: 173  Bit Score: 62.40  E-value: 9.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496843501   2 ILQIVGYKNSGKTTLVEHSVKLLKAQGYRVVTVKHHGHEGD-DislEQGVDHMKHFEAGADQSIVQGHQVQQTVTRT--- 77
Cdd:PRK10751   8 LLAIAAWSGTGKTTLLKKLIPALCARGIRPGLIKHTHHDMDvD---KPGKDSYELRKAGAAQTLVASQQRWALMTETpdq 84

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 496843501  78 DNTDLEAIIANSITIAYDIVIVEGFKKASYDKVILYNNN 116
Cdd:PRK10751  85 EELDLHYLASRMDASKLDLILVEGFKHEPIAKIALFRDG 123
PRK14495 PRK14495
putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion ...
 2-113 2.22e-10

putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional


Pssm-ID: 172967  Cd Length: 452  Bit Score: 57.38  E-value: 2.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496843501   2 ILQIVGYKNSGKTTLVEHSVKLLKAQGYRVVTVKHHGHEGDdiSLEQGVDHMKHFEAGADQSIVQGHQ--VQQTVTRTDN 79
Cdd:PRK14495   3 VYGIIGWKDAGKTGLVERLVAAIAARGFSVSTVKHSHHDVD--PDPPGSDSHRHRAAGAAEVVLAGPRrlILTREHRGEP 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 496843501  80 TDLEAIIANSITIayDIVIVEGFKKASYDKVILY 113
Cdd:PRK14495  81 PRLAAILERMAPV--DLVLVEGYKTEPHPKIEVF 112
PRK14490 PRK14490
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; ...
 7-144 6.61e-08

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional


Pssm-ID: 237728 [Multi-domain]  Cd Length: 369  Bit Score: 50.43  E-value: 6.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496843501   7 GYKNSGKTTLVEHSVKLLKAQgYRVVTVKHHGHEGdDISLEqGVDHMKHFEAGADQSIVQGHQVQQTVTRTDNT-DLEAi 85
Cdd:PRK14490  12 GYSGSGKTTLITALVRRLSER-FSVGYYKHGCHRF-DIDRE-GKDSDLARKAGASTVMISDPEKHALIAGGPPDpLLER- 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496843501  86 ianSITIAYDIVIVEGFKKASYDKVILYNNNDSYYNLSQ---LSHVVYELNTESQLSFKDYD 144
Cdd:PRK14490  88 ---GAFLDCDLLLVEGLKELPLPKILLVDRERKILDLLEqgsVTNVVALVVPDDPASYPDFG 146
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 11-35 3.23e-03

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 36.09  E-value: 3.23e-03
                         10        20
                 ....*....|....*....|....*
gi 496843501  11 SGKTTLVEHSVKLLKAQGYRVVTVK 35
Cdd:cd01672   11 AGKTTLIELLAERLEARGYEVVLTR 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH