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Conserved domains on  [gi|496837965|ref|WP_009380756|]
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MULTISPECIES: transporter associated domain-containing protein [Bilophila]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TlyC super family cl34211
Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction ...
 149-523 2.26e-64

Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction only];


The actual alignment was detected with superfamily member COG1253:

Pssm-ID: 440865 [Multi-domain]  Cd Length: 435  Bit Score: 215.75  E-value: 2.26e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 149 ITSVGMVkeLSIMMLAVIIAVLAMLLASRPLTEFVDRhptVIILCLGFLLMIGLSLILEGLgyhIPKGY--LYA---AIG 223
Cdd:COG1253   67 ITLAGLL--AGALGEAALAALLAPLLGSLGLPAALAH---TLALVLAVVLITFLSLVFGEL---VPKRLalQNPervALL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 224 FSIVVEAFNQLalrnrrnrittrgLR------ESAARAVLELLGGTTIPGGE--TEME---MAALGYsdcRDKVFRPEER 292
Cdd:COG1253  139 VAPPLRLFSRL-------------FRplvwllNGSTNLLLRLLGIEPAEEEPavTEEElraLVEESE---ESGVIEEEER 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 293 AIVARVIRFGGRTVRYIMTPRHKVQWLDSNESPEALLKLVGASKHAFLPVMRGDTDEVLGVVDLRELLWRYQKTGRFSLE 372
Cdd:COG1253  203 EMIENVFEFGDRTVREVMTPRTDVVALDLDDTLEEALELILESGHSRIPVYEGDLDDIVGVVHVKDLLRALLEGEPFDLR 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 373 SSVVPVPMVFEHTGLPDVLDAFRQHPAPMGIVLDEYGSAVGVVTPMDILSAIAGHMGDV--APEPDSFRQPDGSWLLPGR 450
Cdd:COG1253  283 DLLRPPLFVPETKPLDDLLEEFRRERVHMAIVVDEYGGTAGLVTLEDILEEIVGEIRDEydEEEPEIVKLDDGSYLVDGR 362

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496837965 451 MAVDEGLHTLGIQPEEELSCATMAGLLLERLGHIPAAGESLFFWGHLWTVASMDGLRIDQIRIHPQRSGDITE 523
Cdd:COG1253  363 LPIDELNELLGLDLPEEEDYETLGGLVLEQLGRIPEVGETVEVDGLRFEVLDMDGRRIDKVLVTRLPEEEEEE 435
TerC COG0861
Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];
11-228 2.55e-57

Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];


:

Pssm-ID: 440622  Cd Length: 225  Bit Score: 190.26  E-value: 2.55e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965  11 PTAWGGLGTLILLEVVLGIDNLVFISILSSRLPEDKRRHAFTIGLSLALIMRLGLLSTVAWLIGLtkPWFSLLGYSF--- 87
Cdd:COG0861    8 PEAWLALLTLYLLEIVLSIDNAFVIALIFRKLPPEQQKKALFWGILGALVLRIILIFLGAWLLSF--PWILYLGGLFllw 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965  88 TArdiilligglflllkgTMELHERLEGFQPTEEKAVHQAVFWQVITQIVVLDAIFSLDSIITSVGMVKELSIMMLAVII 167
Cdd:COG0861   86 TA----------------IKLLHEKEEEDEENENGKRAATPLWLAVVQIELADLVFSLDSVPAAFGITQDPFLVFTGNIF 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496837965 168 AVLAMLLASRPLTEFVDRHPTVIILCLGFLLMIGLSLILEGLGYHIPKGYLYAAIGFSIVV 228
Cdd:COG0861  150 AILGLRFLAFLLAGLLDRFPYLKYLAAAILGFIGVKLILEDLHFHIPKGYISLAVIFSVLA 210
 
Name Accession Description Interval E-value
TlyC COG1253
Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction ...
 149-523 2.26e-64

Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction only];


Pssm-ID: 440865 [Multi-domain]  Cd Length: 435  Bit Score: 215.75  E-value: 2.26e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 149 ITSVGMVkeLSIMMLAVIIAVLAMLLASRPLTEFVDRhptVIILCLGFLLMIGLSLILEGLgyhIPKGY--LYA---AIG 223
Cdd:COG1253   67 ITLAGLL--AGALGEAALAALLAPLLGSLGLPAALAH---TLALVLAVVLITFLSLVFGEL---VPKRLalQNPervALL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 224 FSIVVEAFNQLalrnrrnrittrgLR------ESAARAVLELLGGTTIPGGE--TEME---MAALGYsdcRDKVFRPEER 292
Cdd:COG1253  139 VAPPLRLFSRL-------------FRplvwllNGSTNLLLRLLGIEPAEEEPavTEEElraLVEESE---ESGVIEEEER 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 293 AIVARVIRFGGRTVRYIMTPRHKVQWLDSNESPEALLKLVGASKHAFLPVMRGDTDEVLGVVDLRELLWRYQKTGRFSLE 372
Cdd:COG1253  203 EMIENVFEFGDRTVREVMTPRTDVVALDLDDTLEEALELILESGHSRIPVYEGDLDDIVGVVHVKDLLRALLEGEPFDLR 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 373 SSVVPVPMVFEHTGLPDVLDAFRQHPAPMGIVLDEYGSAVGVVTPMDILSAIAGHMGDV--APEPDSFRQPDGSWLLPGR 450
Cdd:COG1253  283 DLLRPPLFVPETKPLDDLLEEFRRERVHMAIVVDEYGGTAGLVTLEDILEEIVGEIRDEydEEEPEIVKLDDGSYLVDGR 362

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496837965 451 MAVDEGLHTLGIQPEEELSCATMAGLLLERLGHIPAAGESLFFWGHLWTVASMDGLRIDQIRIHPQRSGDITE 523
Cdd:COG1253  363 LPIDELNELLGLDLPEEEDYETLGGLVLEQLGRIPEVGETVEVDGLRFEVLDMDGRRIDKVLVTRLPEEEEEE 435
TerC COG0861
Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];
11-228 2.55e-57

Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];


Pssm-ID: 440622  Cd Length: 225  Bit Score: 190.26  E-value: 2.55e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965  11 PTAWGGLGTLILLEVVLGIDNLVFISILSSRLPEDKRRHAFTIGLSLALIMRLGLLSTVAWLIGLtkPWFSLLGYSF--- 87
Cdd:COG0861    8 PEAWLALLTLYLLEIVLSIDNAFVIALIFRKLPPEQQKKALFWGILGALVLRIILIFLGAWLLSF--PWILYLGGLFllw 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965  88 TArdiilligglflllkgTMELHERLEGFQPTEEKAVHQAVFWQVITQIVVLDAIFSLDSIITSVGMVKELSIMMLAVII 167
Cdd:COG0861   86 TA----------------IKLLHEKEEEDEENENGKRAATPLWLAVVQIELADLVFSLDSVPAAFGITQDPFLVFTGNIF 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496837965 168 AVLAMLLASRPLTEFVDRHPTVIILCLGFLLMIGLSLILEGLGYHIPKGYLYAAIGFSIVV 228
Cdd:COG0861  150 AILGLRFLAFLLAGLLDRFPYLKYLAAAILGFIGVKLILEDLHFHIPKGYISLAVIFSVLA 210
TerC pfam03741
Integral membrane protein TerC family; This family contains a number of integral membrane ...
 19-208 2.74e-39

Integral membrane protein TerC family; This family contains a number of integral membrane proteins that also contains the TerC protein. TerC has been implicated in resistance to tellurium. This protein may be involved in efflux of tellurium ions. The tellurite-resistant Escherichia coli strain KL53 was found during testing of the group of clinical isolates for antibiotics and heavy metal ion resistance. Determinant of the tellurite resistance of the strain was located on a large conjugative plasmid. Analyses showed, the genes terB, terC, terD and terE are essential for conservation of the resistance. The members of the family contain a number of conserved aspartates that could be involved in binding to metal ions.


Pssm-ID: 461035  Cd Length: 178  Bit Score: 141.07  E-value: 2.74e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965   19 TLILLEVVLGIDNLVFISILSSRLPEDKRRHAFTIGLSLALIMRLGLLSTVAWLIGLTkPWFSLLGYSF---TArdiill 95
Cdd:pfam03741   2 TLVLIEIVLSVDNAFVIALIFRKLPPEQQRKALFWGIGGALVLRILLIFLGVALLELF-DWLLLIGGLFllyTA------ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965   96 igglflllkgTMELHERLEGFQPTEEK-AVHQAVFWQVITQIVVLDAIFSLDSIITSVGMVKELSIMMLAVIIAVLAMLL 174
Cdd:pfam03741  75 ----------IKLLRDLRKLVREEDKKlPVTSSSLWLAVIQIELADLVFSLDSVPAAVGITDDPFIVITGNVFSILGLRF 144

                         170       180       190
                  ....*....|....*....|....*....|....
gi 496837965  175 ASRPLTEFVDRHPTVIILCLGFLLMIGLSLILEG 208
Cdd:pfam03741 145 LSFLLAKLIERFPYLKYLAAAILGFIGVKLLLEG 178
CBS_pair_CorC_HlyC_assoc cd04590
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which ...
 305-421 6.23e-31

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domain; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in magnesium and cobalt efflux, and in association with some proteins of unknown function. The function of the CorC_HlyC domain is uncertain but it might be involved in modulating transport of ion substrates. These CBS domains are found in highly conserved proteins that either have unknown function or are puported to be hemolysins, exotoxins involved in lysis of red blood cells in vitro. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341366 [Multi-domain]  Cd Length: 119  Bit Score: 116.06  E-value: 6.23e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 305 TVRYIMTPRHKVQWLDSNESPEALLKLVGASKHAFLPVMRGDTDEVLGVVDLRELLWRYQKTGR-FSLESSVVPVPMVFE 383
Cdd:cd04590    1 TVREVMTPRTDVVALDADATLEELLELILESGYSRFPVYEGDLDNIIGVLHVKDLLAALLEGREkLDLRALLRPPLFVPE 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 496837965 384 HTGLPDVLDAFRQHPAPMGIVLDEYGSAVGVVTPMDIL 421
Cdd:cd04590   81 TTPLDDLLEEFRKERSHMAIVVDEYGGTAGIVTLEDIL 118
PRK15094 PRK15094
magnesium/cobalt transporter CorC;
289-514 4.32e-22

magnesium/cobalt transporter CorC;


Pssm-ID: 185050 [Multi-domain]  Cd Length: 292  Bit Score: 96.41  E-value: 4.32e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 289 PEERAIVARVIRFGGRTVRYIMTPRHKVQWLDSNESPEALLKLVGASKHAFLPVMRGDTDEVLGVVDLRELLwRYQKTGR 368
Cdd:PRK15094  52 EDTRDMLEGVMDIADQRVRDIMIPRSQMITLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILMAKDLL-PFMRSDA 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 369 --FSLESSVVPVPMVFEHTGLPDVLDAFRQHPAPMGIVLDEYGSAVGVVTPMDILSAIAGHMGDVAPEPD--SFRQ-PDG 443
Cdd:PRK15094 131 eaFSMDKVLRQAVVVPESKRVDRMLKEFRSQRYHMAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDdiDFRQlSRH 210

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496837965 444 SWLLPGRMAVDEGLHTLGIQ-PEEELScaTMAGLLLERLGHIPAAGESLFFWGHLWTVASMDGLRIDQIRIH 514
Cdd:PRK15094 211 TWTVRALASIEDFNEAFGTHfSDEEVD--TIGGLVMQAFGHLPARGETIDIDGYQFKVAMADSRRIIQVHVK 280
CorC_HlyC smart01091
Transporter associated domain; This small domain is found in a family of proteins with the ...
 439-515 1.28e-15

Transporter associated domain; This small domain is found in a family of proteins with the DUF21 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.


Pssm-ID: 215020 [Multi-domain]  Cd Length: 78  Bit Score: 71.70  E-value: 1.28e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496837965   439 RQPDGSWLLPGRMAVDEGLHTLGIQ-PEEELscATMAGLLLERLGHIPAAGESLFFWGHLWTVASMDGLRIDQIRIHP 515
Cdd:smart01091   2 KLDDGSYLVDGRTPIDDLNELLGLDlPEEEY--DTLGGLVLEELGRIPEVGDSVEIGGLRFEVLEVDGRRIDKVRVTR 77
CorC_HlyC pfam03471
Transporter associated domain; This small domain is found in a family of proteins with the ...
 439-517 2.73e-14

Transporter associated domain; This small domain is found in a family of proteins with the pfam01595 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.


Pssm-ID: 460935 [Multi-domain]  Cd Length: 81  Bit Score: 67.96  E-value: 2.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965  439 RQPDGSWLLPGRMAVDEGLHTLGIQ-PEEELscATMAGLLLERLGHIPAAGESL--FFWGHLWTVASMDGLRIDQIRIHP 515
Cdd:pfam03471   2 KLDDGSYLVDGRAPLDDLNELLGLElPEEDY--DTLGGLVLERLGRIPKVGDKVevELGGLRFTVLEMDGRRIKKVRITK 79


                  ..
gi 496837965  516 QR 517
Cdd:pfam03471  80 LE 81
R_switched_YjbE TIGR03717
integral membrane protein, YjbE family; Rfam model RF00080 describes a structured RNA element ...
 17-208 8.94e-13

integral membrane protein, YjbE family; Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family commonly are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains protein YjbE from Bacillus subtilis. A transport function is proposed.


Pssm-ID: 163429  Cd Length: 176  Bit Score: 66.42  E-value: 8.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965   17 LGTLILLEVVLGIDNLVFISILSSRLPEDKRRHAFTIGLSLALIMRLGLLSTVAWLigLTKPWFSLLGysftardiilli 96
Cdd:TIGR03717   2 LLQIIAIDLVLGGDNAVVIALAARNLPAHQRKKAIFWGTAGAIVLRILLTAVAVYL--LAIPFLKLIG------------ 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965   97 ggLFLLLKGTMELHERLEGFQPTEEKAVHQavFWQVITQIVVLDAIFSLDSIITSVGMVKE-LSIMMLAVIIAVLAMLLA 175
Cdd:TIGR03717  68 --GLLLLWIGWKLLLEEEEEQGGDVKGSTT--LWAAIKTIVIADAVMSLDNVLAVAGAAHGhLGLLIFGLLLSIPIIVWG 143

                         170       180       190
                  ....*....|....*....|....*....|...
gi 496837965  176 SRPLTEFVDRHPTVIILCLGFLLMIGLSLILEG 208
Cdd:TIGR03717 144 STLILKLMDRFPWIIYIGAALLGYVAGEMIVTD 176
 
Name Accession Description Interval E-value
TlyC COG1253
Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction ...
 149-523 2.26e-64

Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction only];


Pssm-ID: 440865 [Multi-domain]  Cd Length: 435  Bit Score: 215.75  E-value: 2.26e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 149 ITSVGMVkeLSIMMLAVIIAVLAMLLASRPLTEFVDRhptVIILCLGFLLMIGLSLILEGLgyhIPKGY--LYA---AIG 223
Cdd:COG1253   67 ITLAGLL--AGALGEAALAALLAPLLGSLGLPAALAH---TLALVLAVVLITFLSLVFGEL---VPKRLalQNPervALL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 224 FSIVVEAFNQLalrnrrnrittrgLR------ESAARAVLELLGGTTIPGGE--TEME---MAALGYsdcRDKVFRPEER 292
Cdd:COG1253  139 VAPPLRLFSRL-------------FRplvwllNGSTNLLLRLLGIEPAEEEPavTEEElraLVEESE---ESGVIEEEER 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 293 AIVARVIRFGGRTVRYIMTPRHKVQWLDSNESPEALLKLVGASKHAFLPVMRGDTDEVLGVVDLRELLWRYQKTGRFSLE 372
Cdd:COG1253  203 EMIENVFEFGDRTVREVMTPRTDVVALDLDDTLEEALELILESGHSRIPVYEGDLDDIVGVVHVKDLLRALLEGEPFDLR 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 373 SSVVPVPMVFEHTGLPDVLDAFRQHPAPMGIVLDEYGSAVGVVTPMDILSAIAGHMGDV--APEPDSFRQPDGSWLLPGR 450
Cdd:COG1253  283 DLLRPPLFVPETKPLDDLLEEFRRERVHMAIVVDEYGGTAGLVTLEDILEEIVGEIRDEydEEEPEIVKLDDGSYLVDGR 362

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496837965 451 MAVDEGLHTLGIQPEEELSCATMAGLLLERLGHIPAAGESLFFWGHLWTVASMDGLRIDQIRIHPQRSGDITE 523
Cdd:COG1253  363 LPIDELNELLGLDLPEEEDYETLGGLVLEQLGRIPEVGETVEVDGLRFEVLDMDGRRIDKVLVTRLPEEEEEE 435
TerC COG0861
Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];
11-228 2.55e-57

Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];


Pssm-ID: 440622  Cd Length: 225  Bit Score: 190.26  E-value: 2.55e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965  11 PTAWGGLGTLILLEVVLGIDNLVFISILSSRLPEDKRRHAFTIGLSLALIMRLGLLSTVAWLIGLtkPWFSLLGYSF--- 87
Cdd:COG0861    8 PEAWLALLTLYLLEIVLSIDNAFVIALIFRKLPPEQQKKALFWGILGALVLRIILIFLGAWLLSF--PWILYLGGLFllw 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965  88 TArdiilligglflllkgTMELHERLEGFQPTEEKAVHQAVFWQVITQIVVLDAIFSLDSIITSVGMVKELSIMMLAVII 167
Cdd:COG0861   86 TA----------------IKLLHEKEEEDEENENGKRAATPLWLAVVQIELADLVFSLDSVPAAFGITQDPFLVFTGNIF 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496837965 168 AVLAMLLASRPLTEFVDRHPTVIILCLGFLLMIGLSLILEGLGYHIPKGYLYAAIGFSIVV 228
Cdd:COG0861  150 AILGLRFLAFLLAGLLDRFPYLKYLAAAILGFIGVKLILEDLHFHIPKGYISLAVIFSVLA 210
TerC pfam03741
Integral membrane protein TerC family; This family contains a number of integral membrane ...
 19-208 2.74e-39

Integral membrane protein TerC family; This family contains a number of integral membrane proteins that also contains the TerC protein. TerC has been implicated in resistance to tellurium. This protein may be involved in efflux of tellurium ions. The tellurite-resistant Escherichia coli strain KL53 was found during testing of the group of clinical isolates for antibiotics and heavy metal ion resistance. Determinant of the tellurite resistance of the strain was located on a large conjugative plasmid. Analyses showed, the genes terB, terC, terD and terE are essential for conservation of the resistance. The members of the family contain a number of conserved aspartates that could be involved in binding to metal ions.


Pssm-ID: 461035  Cd Length: 178  Bit Score: 141.07  E-value: 2.74e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965   19 TLILLEVVLGIDNLVFISILSSRLPEDKRRHAFTIGLSLALIMRLGLLSTVAWLIGLTkPWFSLLGYSF---TArdiill 95
Cdd:pfam03741   2 TLVLIEIVLSVDNAFVIALIFRKLPPEQQRKALFWGIGGALVLRILLIFLGVALLELF-DWLLLIGGLFllyTA------ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965   96 igglflllkgTMELHERLEGFQPTEEK-AVHQAVFWQVITQIVVLDAIFSLDSIITSVGMVKELSIMMLAVIIAVLAMLL 174
Cdd:pfam03741  75 ----------IKLLRDLRKLVREEDKKlPVTSSSLWLAVIQIELADLVFSLDSVPAAVGITDDPFIVITGNVFSILGLRF 144

                         170       180       190
                  ....*....|....*....|....*....|....
gi 496837965  175 ASRPLTEFVDRHPTVIILCLGFLLMIGLSLILEG 208
Cdd:pfam03741 145 LSFLLAKLIERFPYLKYLAAAILGFIGVKLLLEG 178
CorB COG4536
Mg2+ and Co2+ transporter CorB, contains DUF21, CBS pair, and CorC-HlyC domains [Inorganic ion ...
 290-517 4.10e-37

Mg2+ and Co2+ transporter CorB, contains DUF21, CBS pair, and CorC-HlyC domains [Inorganic ion transport and metabolism];


Pssm-ID: 443602 [Multi-domain]  Cd Length: 420  Bit Score: 141.75  E-value: 4.10e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 290 EERAIVARVIRFGGRTVRYIMTPRHKVQWLDSNESPEALLKLVGASKHAFLPVMRGDTDEVLGVVDLRELLWRYQKT--G 367
Cdd:COG4536  190 EHRDMLLNILDLEDVTVEDIMVPRNEIEGIDLDDPWEEILKQLLTSPHTRLPVYRGDIDNIVGVLHVRDLLRALRKGdlS 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 368 RFSLESSVVPVPMVFEHTGLPDVLDAFRQHPAPMGIVLDEYGSAVGVVTPMDILSAIaghMGDVAPEPDS-----FRQPD 442
Cdd:COG4536  270 KEDLRKIAREPYFIPETTPLSTQLQNFQKRKRRFALVVDEYGDVQGLVTLEDILEEI---VGEITDEHDPdaeeiRPQED 346

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 496837965 443 GSWLLPGRMAVDEGLHTLGIQ-PEEELScaTMAGLLLERLGHIPAAGESLFFWGHLWTVASMDGLRIDQIRIHPQR 517
Cdd:COG4536  347 GSYLVDGSATIRDLNRALDWNlPDDGAK--TLNGLIIEELEDIPEAGQSFTIHGYRFEILQVQDNRIKTVRIRPLP 420
CBS_pair_CorC_HlyC_assoc cd04590
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which ...
 305-421 6.23e-31

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domain; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in magnesium and cobalt efflux, and in association with some proteins of unknown function. The function of the CorC_HlyC domain is uncertain but it might be involved in modulating transport of ion substrates. These CBS domains are found in highly conserved proteins that either have unknown function or are puported to be hemolysins, exotoxins involved in lysis of red blood cells in vitro. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341366 [Multi-domain]  Cd Length: 119  Bit Score: 116.06  E-value: 6.23e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 305 TVRYIMTPRHKVQWLDSNESPEALLKLVGASKHAFLPVMRGDTDEVLGVVDLRELLWRYQKTGR-FSLESSVVPVPMVFE 383
Cdd:cd04590    1 TVREVMTPRTDVVALDADATLEELLELILESGYSRFPVYEGDLDNIIGVLHVKDLLAALLEGREkLDLRALLRPPLFVPE 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 496837965 384 HTGLPDVLDAFRQHPAPMGIVLDEYGSAVGVVTPMDIL 421
Cdd:cd04590   81 TTPLDDLLEEFRKERSHMAIVVDEYGGTAGIVTLEDIL 118
PRK15094 PRK15094
magnesium/cobalt transporter CorC;
289-514 4.32e-22

magnesium/cobalt transporter CorC;


Pssm-ID: 185050 [Multi-domain]  Cd Length: 292  Bit Score: 96.41  E-value: 4.32e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 289 PEERAIVARVIRFGGRTVRYIMTPRHKVQWLDSNESPEALLKLVGASKHAFLPVMRGDTDEVLGVVDLRELLwRYQKTGR 368
Cdd:PRK15094  52 EDTRDMLEGVMDIADQRVRDIMIPRSQMITLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILMAKDLL-PFMRSDA 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 369 --FSLESSVVPVPMVFEHTGLPDVLDAFRQHPAPMGIVLDEYGSAVGVVTPMDILSAIAGHMGDVAPEPD--SFRQ-PDG 443
Cdd:PRK15094 131 eaFSMDKVLRQAVVVPESKRVDRMLKEFRSQRYHMAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDdiDFRQlSRH 210

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496837965 444 SWLLPGRMAVDEGLHTLGIQ-PEEELScaTMAGLLLERLGHIPAAGESLFFWGHLWTVASMDGLRIDQIRIH 514
Cdd:PRK15094 211 TWTVRALASIEDFNEAFGTHfSDEEVD--TIGGLVMQAFGHLPARGETIDIDGYQFKVAMADSRRIIQVHVK 280
CorC_HlyC smart01091
Transporter associated domain; This small domain is found in a family of proteins with the ...
 439-515 1.28e-15

Transporter associated domain; This small domain is found in a family of proteins with the DUF21 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.


Pssm-ID: 215020 [Multi-domain]  Cd Length: 78  Bit Score: 71.70  E-value: 1.28e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496837965   439 RQPDGSWLLPGRMAVDEGLHTLGIQ-PEEELscATMAGLLLERLGHIPAAGESLFFWGHLWTVASMDGLRIDQIRIHP 515
Cdd:smart01091   2 KLDDGSYLVDGRTPIDDLNELLGLDlPEEEY--DTLGGLVLEELGRIPEVGDSVEIGGLRFEVLEVDGRRIDKVRVTR 77
CorC_HlyC pfam03471
Transporter associated domain; This small domain is found in a family of proteins with the ...
 439-517 2.73e-14

Transporter associated domain; This small domain is found in a family of proteins with the pfam01595 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.


Pssm-ID: 460935 [Multi-domain]  Cd Length: 81  Bit Score: 67.96  E-value: 2.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965  439 RQPDGSWLLPGRMAVDEGLHTLGIQ-PEEELscATMAGLLLERLGHIPAAGESL--FFWGHLWTVASMDGLRIDQIRIHP 515
Cdd:pfam03471   2 KLDDGSYLVDGRAPLDDLNELLGLElPEEDY--DTLGGLVLERLGRIPKVGDKVevELGGLRFTVLEMDGRRIKKVRITK 79


                  ..
gi 496837965  516 QR 517
Cdd:pfam03471  80 LE 81
R_switched_YjbE TIGR03717
integral membrane protein, YjbE family; Rfam model RF00080 describes a structured RNA element ...
 17-208 8.94e-13

integral membrane protein, YjbE family; Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family commonly are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains protein YjbE from Bacillus subtilis. A transport function is proposed.


Pssm-ID: 163429  Cd Length: 176  Bit Score: 66.42  E-value: 8.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965   17 LGTLILLEVVLGIDNLVFISILSSRLPEDKRRHAFTIGLSLALIMRLGLLSTVAWLigLTKPWFSLLGysftardiilli 96
Cdd:TIGR03717   2 LLQIIAIDLVLGGDNAVVIALAARNLPAHQRKKAIFWGTAGAIVLRILLTAVAVYL--LAIPFLKLIG------------ 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965   97 ggLFLLLKGTMELHERLEGFQPTEEKAVHQavFWQVITQIVVLDAIFSLDSIITSVGMVKE-LSIMMLAVIIAVLAMLLA 175
Cdd:TIGR03717  68 --GLLLLWIGWKLLLEEEEEQGGDVKGSTT--LWAAIKTIVIADAVMSLDNVLAVAGAAHGhLGLLIFGLLLSIPIIVWG 143

                         170       180       190
                  ....*....|....*....|....*....|...
gi 496837965  176 SRPLTEFVDRHPTVIILCLGFLLMIGLSLILEG 208
Cdd:TIGR03717 144 STLILKLMDRFPWIIYIGAALLGYVAGEMIVTD 176
R_switched_YkoY TIGR03716
integral membrane protein, YkoY family; Rfam model RF00080 describes a structured RNA element ...
 21-231 1.44e-12

integral membrane protein, YkoY family; Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family often are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains proteins YceF and YkoY from Bacillus subtilis. A transport function is proposed.


Pssm-ID: 274742  Cd Length: 215  Bit Score: 66.91  E-value: 1.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965   21 ILLEVVLGIDNLVFISILSSRLPEDKRRHAFTIGLSLALIMRLGLLSTVAWLIGLtkPWFSLLGYSFTARdiilligglf 100
Cdd:TIGR03716   1 VILEGLLSADNALVLAVMVKHLPEKQRKKALFYGLIGAYVFRFIALFLASFLIKF--WWIKAIGALYLLY---------- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965  101 lllkgtMELHERLEGFQPTE----EKAVHQAVFWQVITQIVVLDAIFSLDSIITSVGMVKELSIMMLAVIIAVLAMLLAS 176
Cdd:TIGR03716  69 ------LAIKHFRKKKKGKEdeeaEKKKAHSGFWRTVLKVELMDIAFSVDSILAAVALSGQFWVVFLGGIIGILIMRFAA 142

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496837965  177 RPLTEFVDRHPT------VIILCLGFLLMIGL--SLILEGLGYHIPKGYLYAAIGFSIVVEAF 231
Cdd:TIGR03716 143 TIFVKLLERFPEletaafLLIGWIGVKLLLETlaHPSIPILHIEFPHSALWKLIFWGVLVAIA 205
PRK11573 PRK11573
hypothetical protein; Provisional
 305-518 2.74e-12

hypothetical protein; Provisional


Pssm-ID: 236933 [Multi-domain]  Cd Length: 413  Bit Score: 68.62  E-value: 2.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 305 TVRYIMTPRHKVQWLDSNESPEALLKLVGASKHAFLPVMRGDTDEVLGVVDLRELLWRYQKTGRFSLESSVVPVPMVF-- 382
Cdd:PRK11573 188 TVDDIMVPRNEIVGIDINDDWKSILRQLTHSPHGRIVLYRDSLDDAISMLRVREAYRLMTEKKEFTKENMLRAADEIYfv 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 383 -EHTGLPDVLDAFRQHPAPMGIVLDEYGSAVGVVTPMDILSAIAG----HMGDVAPEpDSFRQPDGSWLLPGRMAVDEGL 457
Cdd:PRK11573 268 pEGTPLSTQLVKFQRNKKKVGLVVDEYGDIQGLVTVEDILEEIVGdfttSMSPTLAE-EVTPQNDGSVIIDGTANVREIN 346

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496837965 458 HTLGIQ-PEEElsCATMAGLLLERLGHIPAAGESLFFWGHLWTVASMDGLRIDQIRIHPQRS 518
Cdd:PRK11573 347 KAFNWHlPEDD--ARTVNGVILEALEEIPVAGTRVRIGEYDIDILDVQDNMIKQVKVTPVKP 406
COG2524 COG2524
Predicted transcriptional regulator, contains C-terminal CBS domains [Transcription];
225-424 4.49e-08

Predicted transcriptional regulator, contains C-terminal CBS domains [Transcription];


Pssm-ID: 442013 [Multi-domain]  Cd Length: 206  Bit Score: 53.73  E-value: 4.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 225 SIVVEAFNQLALRNRRNRITTRGLRESAARAVLELLGGTTIPGGETEMEMAALGYSDCRDK------VFRPEERAIVARV 298
Cdd:COG2524    1 LLVLLLLALSLLLPLLAVVLAALLLLAALVLALTAAAAATVLLLAAAAAAAGAGGLGLLLLlllivlQAAAVRVVAEKEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 299 IRFGGRTVRYIMTPRhkVQWLDSNESPEALLKLVGASKHAFLPVMrgDTDEVLGVVDLRELLwRYQKTGRFSLESSV--- 375
Cdd:COG2524   81 GLVLKMKVKDIMTKD--VITVSPDTTLEEALELMLEKGISGLPVV--DDGKLVGIITERDLL-KALAEGRDLLDAPVsdi 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 496837965 376 --VPVPMVFEHTGLPDVLDAFRQHPAPMGIVLDEYGSAVGVVTPMDILSAI 424
Cdd:COG2524  156 mtRDVVTVSEDDSLEEALRLMLEHGIGRLPVVDDDGKLVGIITRTDILRAL 206
YtoI COG4109
Predicted transcriptional regulator containing CBS domains [Transcription];
305-423 7.04e-06

Predicted transcriptional regulator containing CBS domains [Transcription];


Pssm-ID: 443285 [Multi-domain]  Cd Length: 135  Bit Score: 45.67  E-value: 7.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 305 TVRYIMTpRHKVQWLDSNESPEALLKLVGASKHAFLPVMRGDtDEVLGVVDLRELLWryqktgrfSLESSVV------PV 378
Cdd:COG4109   17 LVEDIMT-LEDVATLSEDDTVEDALELLEKTGHSRFPVVDEN-GRLVGIVTSKDILG--------KDDDTPIedvmtkNP 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 496837965 379 PMVFEHTGLPDVLDAFRQHPAPMGIVLDEYGSAVGVVTPMDILSA 423
Cdd:COG4109   87 ITVTPDTSLASAAHKMIWEGIELLPVVDDDGRLLGIISRQDVLKA 131
CBS COG0517
CBS domain [Signal transduction mechanisms];
305-425 4.44e-05

CBS domain [Signal transduction mechanisms];


Pssm-ID: 440283 [Multi-domain]  Cd Length: 128  Bit Score: 43.32  E-value: 4.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 305 TVRYIMTPrhKVQWLDSNESPEALLKLVGASKHAFLPVMrGDTDEVLGVVDLRELLWRYQKTGRFSLESSVV-----PVP 379
Cdd:COG0517    2 KVKDIMTT--DVVTVSPDATVREALELMSEKRIGGLPVV-DEDGKLVGIVTDRDLRRALAAEGKDLLDTPVSevmtrPPV 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 496837965 380 MVFEHTGLPDVLDAFRQHPAPMGIVLDEYGSAVGVVTPMDILSAIA 425
Cdd:COG0517   79 TVSPDTSLEEAAELMEEHKIRRLPVVDDDGRLVGIITIKDLLKALL 124
COG3448 COG3448
CBS-domain-containing membrane protein [Signal transduction mechanisms];
305-425 1.12e-04

CBS-domain-containing membrane protein [Signal transduction mechanisms];


Pssm-ID: 442671 [Multi-domain]  Cd Length: 136  Bit Score: 42.16  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 305 TVRYIMTPrhKVQWLDSNESPEALLKLVGASKHAFLPVMRGDtDEVLGVVDLRELLWRYQKTGRFSLESSV--------- 375
Cdd:COG3448    3 TVRDIMTR--DVVTVSPDTTLREALELMREHGIRGLPVVDED-GRLVGIVTERDLLRALLPDRLDELEERLldlpvedvm 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 496837965 376 -VPVPMVFEHTGLPDVLDAFRQHPAPMGIVLDEYGSAVGVVTPMDILSAIA 425
Cdd:COG3448   80 tRPVVTVTPDTPLEEAAELMLEHGIHRLPVVDDDGRLVGIVTRTDLLRALA 130
CBS_pair_SF cd02205
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS ...
 319-421 3.17e-04

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341358 [Multi-domain]  Cd Length: 113  Bit Score: 40.31  E-value: 3.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 319 LDSNESPEALLKLVGASKHAFLPVMRGDtDEVLGVVDLRELLWRYQKtGRFSLESSV-----VPVPMVFEHTGLPDVLDA 393
Cdd:cd02205    7 VDPDTTVREALELMAENGIGALPVVDDD-GKLVGIVTERDILRALVE-GGLALDTPVaevmtPDVITVSPDTDLEEALEL 84

                         90       100
                 ....*....|....*....|....*...
gi 496837965 394 FRQHPAPMGIVLDEYGSAVGVVTPMDIL 421
Cdd:cd02205   85 MLEHGIRRLPVVDDDGKLVGIVTRRDIL 112
CBS_pair_CBS cd04608
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the ...
 340-423 3.63e-04

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. Cystathionine beta-synthase (CBS ) contains, besides the C-terminal regulatory CBS-pair, an N-terminal heme-binding module, followed by a pyridoxal phosphate (PLP) domain, which houses the active site. It is the first enzyme in the transsulfuration pathway, catalyzing the conversion of serine and homocysteine to cystathionine and water. In general, CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341382 [Multi-domain]  Cd Length: 120  Bit Score: 40.21  E-value: 3.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 340 LPVMrGDTDEVLGVVDLRELLwRYQKTGRFSLESSVV-----PVPMVFEHTGLPDVLDAFRQHPApmGIVLDEYGSAVGV 414
Cdd:cd04608   36 LPVV-DEDGRVVGMVTEGNLL-SSLLAGRAQPSDPVSkamykQFKQVDLDTPLGALSRILERDHF--ALVVDGQGKVLGI 111


                 ....*....
gi 496837965 415 VTPMDILSA 423
Cdd:cd04608  112 VTRIDLLNY 120
CBS_pair_voltage-gated_CLC_euk_bac cd04591
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the ...
 305-423 7.28e-04

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC voltage-gated chloride channel. The CBS pairs here are found in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of chloride ions across biological membranes. CIC-type chloride channels come from all kingdoms of life, have several gene families, and can be gated by voltage. The members of the CIC-type chloride channel are double-barreled: two proteins forming homodimers at a broad interface formed by four helices from each protein. The two pores are not found at this interface, but are completely contained within each subunit, as deduced from the mutational analyses, unlike many other channels, in which four or five identical or structurally related subunits jointly form one pore. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341367 [Multi-domain]  Cd Length: 114  Bit Score: 39.42  E-value: 7.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496837965 305 TVRYIMTPrhKVQWLDSNESPEALLKLVGASKHAFLPVMRGDTDEVL-GVVDLRELLWRYQKtgrfSLESSVVPVPM-VF 382
Cdd:cd04591    1 TAEDVMRP--PLTVLARDETVGDIVSVLKTTDHNGFPVVDSTESQTLvGFILRSQLILLLEA----DLRPIMDPSPFtVT 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 496837965 383 EHTGLPDVLDAFRQhpapMG---IVLDEYGSAVGVVTPMDILSA 423
Cdd:cd04591   75 EETSLEKVHDLFRL----LGlrhLLVTNNGRLVGIVTRKDLLRA 114
CBS pfam00571
CBS domain; CBS domains are small intracellular modules that pair together to form a stable ...
 377-426 3.07e-03

CBS domain; CBS domains are small intracellular modules that pair together to form a stable globular domain. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet. CBS domain pairs from AMPK bind AMP or ATP. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP.


Pssm-ID: 425756 [Multi-domain]  Cd Length: 57  Bit Score: 36.04  E-value: 3.07e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 496837965  377 PVPMVFEHTGLPDVLDAFRQHPAPMGIVLDEYGSAVGVVTPMDILSAIAG 426
Cdd:pfam00571   8 DVVTVSPDTTLEEALELMREHGISRLPVVDEDGKLVGIVTLKDLLRALLG 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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