NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|496558469|ref|WP_009264544|]
View 

DeoR/GlpR family DNA-binding transcription regulator [Anaerostipes hadrus]

Protein Classification

DeoR/GlpR family DNA-binding transcription regulator( domain architecture ID 11442564)

DeoR/GlpR family DNA-binding transcription regulator is a helix-turn-helix type transcriptional regulator that may be involved in sugar metabolism

Gene Ontology:  GO:0003700|GO:0003677
PubMed:  15808743

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 5-253 8.37e-77

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


:

Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 232.72  E-value: 8.37e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469   5 NAQNRQEQIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENGSIKKGFGGAIAVNDFTT-LPIDSRLLDEHDAKKR 83
Cdd:COG1349    2 LAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAePPFAERETLNAEEKRA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469  84 IARKALSFIPEHGFIYLDTGSTTLSLALELKNLSGYTIITNSIPVLTTLIDSKN-HLIFLGGECNAEIMCSVGVQVIELL 162
Cdd:COG1349   82 IARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNiEVILLGGELRPSSGSLVGPLAEEAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469 163 KTLRVDIAFLGSAGFEQHHGPATNAFADGQIKSCAISCAQTSIVLCDSRKAKYSSFQQYASWNEIDHLISDTDFPQEFAD 242
Cdd:COG1349  162 RRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELLE 241

                        250
                 ....*....|..
gi 496558469 243 KLQEF-TNVILV 253
Cdd:COG1349  242 ALEEAgVEVIVA 253
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 5-253 8.37e-77

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 232.72  E-value: 8.37e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469   5 NAQNRQEQIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENGSIKKGFGGAIAVNDFTT-LPIDSRLLDEHDAKKR 83
Cdd:COG1349    2 LAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAePPFAERETLNAEEKRA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469  84 IARKALSFIPEHGFIYLDTGSTTLSLALELKNLSGYTIITNSIPVLTTLIDSKN-HLIFLGGECNAEIMCSVGVQVIELL 162
Cdd:COG1349   82 IARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNiEVILLGGELRPSSGSLVGPLAEEAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469 163 KTLRVDIAFLGSAGFEQHHGPATNAFADGQIKSCAISCAQTSIVLCDSRKAKYSSFQQYASWNEIDHLISDTDFPQEFAD 242
Cdd:COG1349  162 RRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELLE 241

                        250
                 ....*....|..
gi 496558469 243 KLQEF-TNVILV 253
Cdd:COG1349  242 ALEEAgVEVIVA 253
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 78-234 1.44e-40

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 137.26  E-value: 1.44e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469   78 HDAKKRIARKALSFIPEHGFIYLDTGSTTLSLALELKNLSGYTIITNSIPVLTTLIDSKN-HLIFLGGECNAEIMCSVGV 156
Cdd:pfam00455   3 AEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDiEVILLGGEVRPKTGAFVGP 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496558469  157 QVIELLKTLRVDIAFLGSAGFEQHHGPATNAFADGQIKSCAISCAQTSIVLCDSRKAKYSSFQQYASWNEIDHLISDT 234
Cdd:pfam00455  83 LAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
PRK09802 PRK09802
DeoR family transcriptional regulator;
4-253 1.19e-26

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 104.17  E-value: 1.19e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469   4 LNAQNRQEQIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENGSIKKGFGGAIAVnDFTTLPIDSRLLDEHD---- 79
Cdd:PRK09802  13 TGTSERREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALIC-DSTTPSVEPSVEDKSAlnta 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469  80 AKKRIARKALSFI-PEHGFIyLDTGSTTLSLALELKNLSGYTIITNSIPVLTTLIDSKN-HLIFLGGECNAEIMCSVGVQ 157
Cdd:PRK09802  92 MKRSVAKAAVELIqPGHRVI-LDSGTTTFEIARLMRKHTDVIAMTNGMNVANALLEAEGvELLMTGGHLRRQSQSFYGDQ 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469 158 VIELLKTLRVDIAFLGSAGFEQHHGPATNAFADGQIKSCAISCAQTSIVLCDSRKAKYSSFQQYASWNEIDHLISDTDFP 237
Cdd:PRK09802 171 AEQSLQNYHFDMLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIP 250

                        250
                 ....*....|....*..
gi 496558469 238 QEFADKLQEF-TNVILV 253
Cdd:PRK09802 251 ADSLEGLRKAgVEVILV 267
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
9-60 4.18e-15

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 67.63  E-value: 4.18e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 496558469     9 RQEQIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENGSIKKGFGGAI 60
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAV 52
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 11-64 4.98e-04

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 37.65  E-value: 4.98e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 496558469  11 EQIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENGSIKKGFGGAIAVND 64
Cdd:cd00092   14 LRYGAGDLVQLPLTRQEIADYLGLTRETVSRTLKELEEEGLISRRGRGKYRVNP 67
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 5-253 8.37e-77

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 232.72  E-value: 8.37e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469   5 NAQNRQEQIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENGSIKKGFGGAIAVNDFTT-LPIDSRLLDEHDAKKR 83
Cdd:COG1349    2 LAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAePPFAERETLNAEEKRA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469  84 IARKALSFIPEHGFIYLDTGSTTLSLALELKNLSGYTIITNSIPVLTTLIDSKN-HLIFLGGECNAEIMCSVGVQVIELL 162
Cdd:COG1349   82 IARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNiEVILLGGELRPSSGSLVGPLAEEAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469 163 KTLRVDIAFLGSAGFEQHHGPATNAFADGQIKSCAISCAQTSIVLCDSRKAKYSSFQQYASWNEIDHLISDTDFPQEFAD 242
Cdd:COG1349  162 RRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELLE 241

                        250
                 ....*....|..
gi 496558469 243 KLQEF-TNVILV 253
Cdd:COG1349  242 ALEEAgVEVIVA 253
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 78-234 1.44e-40

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 137.26  E-value: 1.44e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469   78 HDAKKRIARKALSFIPEHGFIYLDTGSTTLSLALELKNLSGYTIITNSIPVLTTLIDSKN-HLIFLGGECNAEIMCSVGV 156
Cdd:pfam00455   3 AEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDiEVILLGGEVRPKTGAFVGP 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496558469  157 QVIELLKTLRVDIAFLGSAGFEQHHGPATNAFADGQIKSCAISCAQTSIVLCDSRKAKYSSFQQYASWNEIDHLISDT 234
Cdd:pfam00455  83 LAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
PRK09802 PRK09802
DeoR family transcriptional regulator;
4-253 1.19e-26

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 104.17  E-value: 1.19e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469   4 LNAQNRQEQIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENGSIKKGFGGAIAVnDFTTLPIDSRLLDEHD---- 79
Cdd:PRK09802  13 TGTSERREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALIC-DSTTPSVEPSVEDKSAlnta 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469  80 AKKRIARKALSFI-PEHGFIyLDTGSTTLSLALELKNLSGYTIITNSIPVLTTLIDSKN-HLIFLGGECNAEIMCSVGVQ 157
Cdd:PRK09802  92 MKRSVAKAAVELIqPGHRVI-LDSGTTTFEIARLMRKHTDVIAMTNGMNVANALLEAEGvELLMTGGHLRRQSQSFYGDQ 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469 158 VIELLKTLRVDIAFLGSAGFEQHHGPATNAFADGQIKSCAISCAQTSIVLCDSRKAKYSSFQQYASWNEIDHLISDTDFP 237
Cdd:PRK09802 171 AEQSLQNYHFDMLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIP 250

                        250
                 ....*....|....*..
gi 496558469 238 QEFADKLQEF-TNVILV 253
Cdd:PRK09802 251 ADSLEGLRKAgVEVILV 267
srlR PRK10434
DNA-binding transcriptional repressor;
7-253 1.85e-26

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 103.23  E-value: 1.85e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469   7 QNRQEQIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENGSIKKGFGGAIAVNDFTTLPIDSRLLDEHDAKKRIAR 86
Cdd:PRK10434   4 RQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINTHKKELIAE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469  87 KALSFIPEHGFIYLDTGSTTLSLALELKNLSGYTIITNSIPVLTTLI--DSKNHLIFLGG---ECNAEIMCSVGVQVIEl 161
Cdd:PRK10434  84 AAVSLIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSelDNEQTILMPGGtfrKKSASFHGQLAENAFE- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469 162 lkTLRVDIAFLGSAGFEQHHGPATnaFADG-QIKSCAISCAQTSIVLCDSRKAKYSSFQQYASWNEIDHLISDTDFPQEF 240
Cdd:PRK10434 163 --HFTFDKLFIGTDGIDLNAGVTT--FNEVyTVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDPAF 238

                        250
                 ....*....|....
gi 496558469 241 ADKLQEF-TNVILV 253
Cdd:PRK10434 239 RQALEEKgIEVIIT 252
PRK10411 PRK10411
L-fucose operon activator;
9-233 1.13e-25

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 100.65  E-value: 1.13e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469   9 RQEQIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENGSIKKGFGGAIAV---NDFTTLPIDSRLLDEHDAKKRIA 85
Cdd:PRK10411   5 RQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAKYIhrqNQDSGDPFHIRLKSHYAHKADIA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469  86 RKALSFIPEHGFIYLDTGSTTLSLALELKNLSgYTIITNSIPVLTTLIDSKN-HLIFLGGECNAEIMCSVGVQVIELLKT 164
Cdd:PRK10411  85 REALAWIEEGMVIALDASSTCWYLARQLPDIN-IQVFTNSHPICQELGKRERiQLISSGGTLERKYGCYVNPSLISQLKS 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 496558469 165 LRVDIAFLGSAGFEQHHGPATNAFADGQIKSCAISCAQTSIVLCDSRKAKYSSFQQYASWNEIDHLISD 233
Cdd:PRK10411 164 LEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISD 232
PRK10906 PRK10906
DeoR/GlpR family transcriptional regulator;
9-238 5.21e-24

DeoR/GlpR family transcriptional regulator;


Pssm-ID: 182827 [Multi-domain]  Cd Length: 252  Bit Score: 96.85  E-value: 5.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469   9 RQEQIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENGSIKKGFGGAIAVNDFTTLPIDSRLLDEHDAKKRIARKA 88
Cdd:PRK10906   6 RHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAALPSSSVNTPWHDRKATQTEEKERIARKV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469  89 LSFIPEHGFIYLDTGSTTLSLALELKNLSGYTIITNSIPVLTTLIDSKN-HLIFLGGECNAEIMCSVGVQVIELLKTLRV 167
Cdd:PRK10906  86 ASQIPNGATLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMAKEDfRIILAGGELRSRDGGIIGEATLDFISQFRL 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496558469 168 DIAFLGSAGFEQHHGPATNAFADGQIKSCAISCAQTSIVLCDSRKAKYSSFQQYASWNEIDHLISDTDFPQ 238
Cdd:PRK10906 166 DFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDQLPPA 236
PRK13509 PRK13509
HTH-type transcriptional regulator UlaR;
4-253 4.74e-21

HTH-type transcriptional regulator UlaR;


Pssm-ID: 184100 [Multi-domain]  Cd Length: 251  Bit Score: 88.52  E-value: 4.74e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469   4 LNAQNRQEQIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENGSIKKGFGGA--IAVNDFTTLPIDSRLLDEHDAK 81
Cdd:PRK13509   1 MTEAQRHQILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLKKVRNGAeaITQQRPRWTPMNIHQAQNHDEK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469  82 KRIARKALSFIPEHGFIYLDTGSTTLSLALEL--KNLSgytIITNSIPVLTTLIDsKNH--LIFLGGECNAE--IMCSVG 155
Cdd:PRK13509  81 VRIAKAASQLCNPGESVVINCGSTAFLLGRELcgKPVQ---IITNYLPLANYLID-QEHdsVIIMGGQYNKSqsITLSPQ 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469 156 VQVIELLKTlrvDIAFLGSAGFEqhhgpatnafADGQIKS---CAISCAQTS------IVLCDSRKAKYSSFQQYASWNE 226
Cdd:PRK13509 157 GSENSLYAG---HWMFTSGKGLT----------ADGLYKTdmlTAMAEQKMLsvvgklVVLVDSSKIGERAGMLFSRADQ 223

                        250       260
                 ....*....|....*....|....*...
gi 496558469 227 IDHLISDTDFPQEFADKLQEF-TNVILV 253
Cdd:PRK13509 224 IDMLITGKNADPEVLQQLEAQgVSILLV 251
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
9-60 4.18e-15

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 67.63  E-value: 4.18e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 496558469     9 RQEQIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENGSIKKGFGGAI 60
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAV 52
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
9-63 9.66e-15

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 66.51  E-value: 9.66e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 496558469    9 RQEQIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENGSIKKGFGGAIAVN 63
Cdd:pfam08220   1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAVSNS 55
PRK10681 PRK10681
DNA-binding transcriptional repressor DeoR; Provisional
 9-212 4.22e-11

DNA-binding transcriptional repressor DeoR; Provisional


Pssm-ID: 182644 [Multi-domain]  Cd Length: 252  Bit Score: 61.25  E-value: 4.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469   9 RQEQIIELLNNNGSMKATELADYFSVSRETIRRDLNtlSENGSIKKgFGGAI-----AVNDFTTLPIDSRLLDEhdaKKR 83
Cdd:PRK10681   8 RIGQLLQALKRSDKLHLKDAAALLGVSEMTIRRDLN--AHSAPVVL-LGGYIvleprSASHYLLSDQKSRLVEE---KRR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469  84 IARKALSFIPEHGFIYLDTGSTTLSLALELKNLSGYTIITNSIPVLTTLIDSKN-HLIFLGGECNAE--IMCSVGVQviE 160
Cdd:PRK10681  82 AAQLAATLVEPNQTLFFDCGTTTPWIIEAIDNELPFTAVCYSLNTFLALQEKPHcRAILCGGEFHASnaIFKPLDFQ--Q 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 496558469 161 LLKTLRVDIAFLGSAGFEQHHGPATNAFADGQIKSCAISCAQTSIVLCDSRK 212
Cdd:PRK10681 160 TLDNICPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMAMAQKHVLVVDHSK 211
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 1-69 8.28e-09

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 55.08  E-value: 8.28e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496558469   1 MARLNaqnRQEQIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENG---SIKKGFGGAIAVNDFTTLP 69
Cdd:COG2378    1 MSRLE---RLLALLQLLQSRRGVTAAELAERLEVSERTIYRDIDALRELGvpiEAERGRGGGYRLRDGYRLP 69
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 11-50 4.27e-07

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 45.50  E-value: 4.27e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 496558469   11 EQIIELLNNNGS-MKATELADYFSVSRETIRRDLNTLSENG 50
Cdd:pfam08279   1 LQILQLLLEARGpISGQELAEKLGVSRRTIRRDIKILEELG 41
PRK04424 PRK04424
transcription factor FapR;
2-42 5.71e-05

transcription factor FapR;


Pssm-ID: 179847 [Multi-domain]  Cd Length: 185  Bit Score: 42.50  E-value: 5.71e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 496558469   2 ARLNAQNRQEQIIELLNNNGSMKATELADYFSVSRETIRRD 42
Cdd:PRK04424   1 MKLSKKERQKALQELIEENPFITDEELAEKFGVSIQTIRLD 41
COG3177 COG3177
Fic family protein [Transcription];
9-54 9.04e-05

Fic family protein [Transcription];


Pssm-ID: 442410 [Multi-domain]  Cd Length: 316  Bit Score: 42.75  E-value: 9.04e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 496558469   9 RQEQIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENGSIKK 54
Cdd:COG3177  262 RQRKLLELLFENPVLTASELAELLGVSRRTARRDLKDLVELGILEK 307
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 12-54 9.26e-05

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 40.58  E-value: 9.26e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 496558469    12 QIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENGSIKK 54
Cdd:smart00344   7 KILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKG 49
NiaR COG1827
Transcriptional regulator of NAD metabolism, contains HTH and 3H domains [Transcription, ...
 4-46 4.94e-04

Transcriptional regulator of NAD metabolism, contains HTH and 3H domains [Transcription, Coenzyme transport and metabolism];


Pssm-ID: 441432 [Multi-domain]  Cd Length: 171  Bit Score: 39.73  E-value: 4.94e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 496558469   4 LNAQNRQEQIIELLNNNGS-MKATELADYFSVSRETIRRDLNTL 46
Cdd:COG1827    1 MDGEERREKILEILKESKEpISGSELAKKFGVSRQVIVQDIALL 44
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 11-64 4.98e-04

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 37.65  E-value: 4.98e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 496558469  11 EQIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENGSIKKGFGGAIAVND 64
Cdd:cd00092   14 LRYGAGDLVQLPLTRQEIADYLGLTRETVSRTLKELEEEGLISRRGRGKYRVNP 67
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
9-50 1.13e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 39.14  E-value: 1.13e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 496558469   9 RQEQIIELLNNNGSMKATELADYFSVSRETIRRDLNTLSENG 50
Cdd:COG2345   14 TRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEG 55
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
12-126 1.18e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 39.49  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496558469  12 QIIELLNNnGSMKATELADYFSVSRETIRRDLNTLSENGSIKKGFG-------GAIAVNDFTtlPIDSRLLDEHDAKKRI 84
Cdd:COG4742   20 NILLLLAE-GPKTRSELAESLDVSRSTILRQLKELEERGLIERDDGeyelttlGRLVVEEME--PLLDTLEVLEENRDYW 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 496558469  85 ARKALSFIPEHgfiyldtgsttlsLALELKNLSGYTIITNSI 126
Cdd:COG4742   97 ETHDLSAIPPE-------------LLLRIGELGDATVIEPDL 125
BglG COG3711
Transcriptional antiterminator [Transcription];
13-46 1.30e-03

Transcriptional antiterminator [Transcription];


Pssm-ID: 442925 [Multi-domain]  Cd Length: 618  Bit Score: 39.84  E-value: 1.30e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 496558469  13 IIELLNNNGSMKATELADYFSVSRETIRRDLNTL 46
Cdd:COG3711    2 LKILLKNNNVVTAKELAKKLNVSERTIRYDIKKI 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH