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Conserved domains on  [gi|496532503|ref|WP_009239194|]
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MULTISPECIES: ANTAR domain-containing response regulator [Ralstonia]

Protein Classification

ANTAR domain-containing response regulator( domain architecture ID 11467116)

ANTAR domain-containing response regulator, a response regulator with a signal receiver (REC) domain and RNA binding antiterminator (ANTAR) domain involved in transcriptional antitermination, similar to Mycobacterium tuberculosis transcriptional regulatory protein pdtaR that is a member of the two-component regulatory system pdtaR/pdtaS

Gene Ontology:  GO:0000160
PubMed:  11557134|20226724|16740923|11796212|18076326|11934609
SCOP:  4003632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 21-212 3.94e-57

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 179.00  E-value: 3.94e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532503  21 MRVLLVrdplDAEQINLELIRAGLAEAGFVDVGLADADLTLPERIAETQPDMVIVASESAARDTIEHVCVATQHAPRPIV 100
Cdd:COG3707    4 LRVLVV----DDEPLRRADLREGLREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532503 101 LFTDNDDATRIKTAFAAGITAYIVDGIKPTRVKAVLDVAYARFEHERELRAELDTAKTQLAERKVLERAKGMLMKQMNLS 180
Cdd:COG3707   80 LLTAYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALRRELAKLREALEERKLIERAKGILMERRGLS 159

                        170       180       190
                 ....*....|....*....|....*....|..
gi 496532503 181 EDDAFKRLRKMAMDRNIKLVEAAQRVIDVMAG 212
Cdd:COG3707  160 EDEAYRLLRKQAMDRRVKLAEVAEAILAAAEL 191
 
Name Accession Description Interval E-value
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 21-212 3.94e-57

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 179.00  E-value: 3.94e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532503  21 MRVLLVrdplDAEQINLELIRAGLAEAGFVDVGLADADLTLPERIAETQPDMVIVASESAARDTIEHVCVATQHAPRPIV 100
Cdd:COG3707    4 LRVLVV----DDEPLRRADLREGLREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532503 101 LFTDNDDATRIKTAFAAGITAYIVDGIKPTRVKAVLDVAYARFEHERELRAELDTAKTQLAERKVLERAKGMLMKQMNLS 180
Cdd:COG3707   80 LLTAYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALRRELAKLREALEERKLIERAKGILMERRGLS 159

                        170       180       190
                 ....*....|....*....|....*....|..
gi 496532503 181 EDDAFKRLRKMAMDRNIKLVEAAQRVIDVMAG 212
Cdd:COG3707  160 EDEAYRLLRKQAMDRRVKLAEVAEAILAAAEL 191
ANTAR smart01012
ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found ...
 153-207 1.61e-15

ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; The majority of the domain consists of a coiled-coil.


Pssm-ID: 198080 [Multi-domain]  Cd Length: 55  Bit Score: 67.89  E-value: 1.61e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 496532503   153 LDTAKTQLAERKVLERAKGMLMKQMNLSEDDAFKRLRKMAMDRNIKLVEAAQRVI 207
Cdd:smart01012   1 LEQLREALESRKVIEQAKGILMERRGLSEEEAFELLRKLAMDRNVKLRDVAEAIV 55
ANTAR pfam03861
ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding ...
 160-204 4.22e-15

ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.


Pssm-ID: 427550 [Multi-domain]  Cd Length: 46  Bit Score: 66.59  E-value: 4.22e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 496532503  160 LAERKVLERAKGMLMKQMNLSEDDAFKRLRKMAMDRNIKLVEAAQ 204
Cdd:pfam03861   2 LESRKVIEQAKGILMERLGLSEDEAFRLLRKLSMDRNVKLREVAE 46
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 21-142 2.94e-05

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 42.02  E-value: 2.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532503  21 MRVLLVRD-PLdaeqINLELiRAGLAEAGFVDVGLADADLTLPERIAETQPDMVIVASESAARDTIEHVCVATQHAPRPI 99
Cdd:cd19932    1 VRVLIAEDeAL----IRMDL-REMLEEAGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIAPI 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 496532503 100 VLFTDNDDATRIKTAFAAGITAYIVDGIKPTRVKAVLDVAYAR 142
Cdd:cd19932   76 VLLTAYSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAIAR 118
 
Name Accession Description Interval E-value
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 21-212 3.94e-57

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 179.00  E-value: 3.94e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532503  21 MRVLLVrdplDAEQINLELIRAGLAEAGFVDVGLADADLTLPERIAETQPDMVIVASESAARDTIEHVCVATQHAPRPIV 100
Cdd:COG3707    4 LRVLVV----DDEPLRRADLREGLREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532503 101 LFTDNDDATRIKTAFAAGITAYIVDGIKPTRVKAVLDVAYARFEHERELRAELDTAKTQLAERKVLERAKGMLMKQMNLS 180
Cdd:COG3707   80 LLTAYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALRRELAKLREALEERKLIERAKGILMERRGLS 159

                        170       180       190
                 ....*....|....*....|....*....|..
gi 496532503 181 EDDAFKRLRKMAMDRNIKLVEAAQRVIDVMAG 212
Cdd:COG3707  160 EDEAYRLLRKQAMDRRVKLAEVAEAILAAAEL 191
ANTAR smart01012
ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found ...
 153-207 1.61e-15

ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; The majority of the domain consists of a coiled-coil.


Pssm-ID: 198080 [Multi-domain]  Cd Length: 55  Bit Score: 67.89  E-value: 1.61e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 496532503   153 LDTAKTQLAERKVLERAKGMLMKQMNLSEDDAFKRLRKMAMDRNIKLVEAAQRVI 207
Cdd:smart01012   1 LEQLREALESRKVIEQAKGILMERRGLSEEEAFELLRKLAMDRNVKLRDVAEAIV 55
ANTAR pfam03861
ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding ...
 160-204 4.22e-15

ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.


Pssm-ID: 427550 [Multi-domain]  Cd Length: 46  Bit Score: 66.59  E-value: 4.22e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 496532503  160 LAERKVLERAKGMLMKQMNLSEDDAFKRLRKMAMDRNIKLVEAAQ 204
Cdd:pfam03861   2 LESRKVIEQAKGILMERLGLSEDEAFRLLRKLSMDRNVKLREVAE 46
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 21-143 2.17e-05

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 43.36  E-value: 2.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532503  21 MRVLLVrdplDAEQINLELIRAGLAEAGFVDVGLADADLTLpERIAETQPDMVIVASESAARDTIEhVCVATQHAPR--- 97
Cdd:COG3706    2 ARILVV----DDDPTNRKLLRRLLEAAGYEVVEAADGEEAL-ELLQEHRPDLILLDLEMPDMDGLE-LCRRLRADPRtad 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 496532503  98 -PIVLFTDNDDATRIKTAFAAGITAYIVDGIKPTRVKAVLDVAyARF 143
Cdd:COG3706   76 iPIIFLTALDDEEDRARALEAGADDYLTKPFDPEELLARVDLV-ARY 121
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 21-142 2.94e-05

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 42.02  E-value: 2.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532503  21 MRVLLVRD-PLdaeqINLELiRAGLAEAGFVDVGLADADLTLPERIAETQPDMVIVASESAARDTIEHVCVATQHAPRPI 99
Cdd:cd19932    1 VRVLIAEDeAL----IRMDL-REMLEEAGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIAPI 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 496532503 100 VLFTDNDDATRIKTAFAAGITAYIVDGIKPTRVKAVLDVAYAR 142
Cdd:cd19932   76 VLLTAYSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAIAR 118
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 21-170 5.86e-05

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 43.03  E-value: 5.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532503  21 MRVLLVRDpldaEQINLELIRAGLAEAGFVDVGLADADLTLpERIAETQPDMVIVASESAARDTIEHVCVATQHAPR-PI 99
Cdd:COG2204    3 ARILVVDD----DPDIRRLLKELLERAGYEVETAASGEEAL-ALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDlPV 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496532503 100 VLFTDNDDATRIKTAFAAGITAYIVDGIKPTRVKAVLDVAYARFEHERELRAELDTAKTQLAERKVLERAK 170
Cdd:COG2204   78 ILLTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLRRENAEDSGLIGRSPAMQEVRRLIE 148
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 21-154 1.56e-04

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 41.30  E-value: 1.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532503  21 MRVLLVrdplDAEQINLELIRAGLAEAGFVDVGLADADLTLpERIAETQPDMVIVASESAARDTIEhVCVATQHAPR--- 97
Cdd:COG3437    7 PTVLIV----DDDPENLELLRQLLRTLGYDVVTAESGEEAL-ELLLEAPPDLILLDVRMPGMDGFE-LLRLLRADPStrd 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 496532503  98 -PIVLFTDNDDATRIKTAFAAGITAYIVDGIKPTRVKAVLDVAYARFEHERELRAELD 154
Cdd:COG3437   81 iPVIFLTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRRLQRELDDLVL 138
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 21-136 4.05e-03

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 36.86  E-value: 4.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532503  21 MRVLLVrdplDAEQINLELIRAGLAEAGFVDVGLADADLTLpERIAETQPDMVIVASESAARDTIEhVC--VATQHAPRP 98
Cdd:COG0745    2 PRILVV----EDDPDIRELLADALEREGYEVDTAADGEEAL-ELLEEERPDLILLDLMLPGMDGLE-VCrrLRARPSDIP 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 496532503  99 IVLFTDNDDATRIKTAFAAGITAYIVdgiKP-------TRVKAVL 136
Cdd:COG0745   76 IIMLTARDDEEDRVRGLEAGADDYLT---KPfdpeellARIRALL 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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